Group musical performance, especially large instrumental ensembles, present the outward appearance of an asymmetric, temporally immediate stimulus-response relationship between conductor and ensemble. Interestingly, anecdotal reports from both conductors and performers indicate a degree of variability in the timing of orchestral response to the conductor’s gestures. This observation is not present in anecdotal accounts of other instrumental ensemble settings, like wind bands, but commonplace occurrence among orchestral musicians indicates the potential presence of greater complexity in the observed relationship. This study investigates (...) both the quality and quantity of temporal lag between conductor and ensemble in two common instrumental ensemble configurations – wind bands and orchestras – in an effort to describe the interplay present within conducted group performance. The findings indicate that the anecdotally identified lag is present within all ensemble types, and that it presents a flexible, dynamic temporal relationship between conductor and ensemble. Additionally, both the quantity and quality of lag values are significantly different between ensemble types, experience levels, and musical content. Several avenues for future research are identified, and confounds within the sampled ensembles are examined for their potential roles in the observed relationships. (shrink)

Debate on free will with Christian List, Gregg Caruso, and Cory Clark. The exchange is focused on Christian List's book Why Free Will Is Real.

Mitochondrial DNA (mtDNA) mutations escalate with increasing age in higher organisms. However, it has so far been difficult to experimentally determine whether mtDNA mutation merely correlates with age or directly limits lifespan. A recent study shows that budding yeast can also lose functional mtDNA late in life. Interestingly, independent studies of replicative lifespan (RLS) and of mtDNA‐deficient cells show that the same mutations can increase both RLS and the division rate of yeast lacking the mitochondrial genome. These exciting, parallel findings (...) imply a potential causal relationship between mtDNA mutation and replicative senescence. Furthermore, these results suggest more efficient methods for discovering genes that determine lifespan. (shrink)

Traditional whistleblowing theories have purported that whistleblowers engage in a rational process in determining whether or not to blow the whistle on misconduct. However, stressors inherent to whistleblowing often impede rational thinking and act as a barrier to effective whistleblowing. The negative impact of these stressors on whistleblowing may be made worse depending on who engages in the misconduct: a peer or advisor. In the present study, participants are presented with an ethical scenario where either a peer or advisor engages (...) in misconduct, and positive and the negative consequences of whistleblowing are either directed to the wrongdoer, department, or university. Participant responses to case questions were evaluated for whistleblowing intentions, moral intensity, metacognitive reasoning strategies, and positive and negative, active and passive emotions. Findings indicate that participants were less likely to report the observed misconduct of an advisor compared to a peer. Furthermore, the findings also suggest that when an advisor is the source of misconduct, greater negative affect results. Post-hoc analyses were also conducted examining the differences between those who did and did not intend to blow the whistle under the circumstances of either having to report an advisor or peer. The implications of these findings for understanding the complexities involved in whistleblowing are discussed. (shrink)

Building on the advances made by feminist reconsiderations of methods, methodology and epistemology, this paper calls for an alliance between feminist social science and the emerging field of queer theory. By challenging traditional scientific approaches to research on sexual minority groups, a distinctly ‘queer’ approach is advocated that adopts a reflexive position on subjectivity and sexuality. While essentialist approaches privilege gay/lesbian, man/woman, and object/subject, this approach advances a framework of critical sexualities that moves social science into an arena of inclusivity (...) and multiple identities, rather than reductionistic categorical thought. The implications are clear: a rethinking of identity categories that transcend stagnant dualisms. (shrink)

Building on the advances made by feminist reconsiderations of methods, methodology and epistemology, this paper calls for an alliance between feminist social science and the emerging field of queer theory. By challenging traditional scientific approaches to research on sexual minority groups, a distinctly ‘queer’ approach is advocated that adopts a reflexive position on subjectivity and sexuality. While essentialist approaches privilege gay/lesbian, man/woman, and object/subject, this approach advances a framework of critical sexualities that moves social science into an arena of inclusivity (...) and multiple identities, rather than reductionistic categorical thought. The implications are clear: a rethinking of identity categories that transcend stagnant dualisms. (shrink)

Traditional whistleblowing theories have purported that whistleblowers engage in a rational process in determining whether or not to blow the whistle on misconduct. However, stressors inherent to whistleblowing often impede rational thinking and act as a barrier to effective whistleblowing. The negative impact of these stressors on whistleblowing may be made worse depending on who engages in the misconduct: a peer or advisor. In the present study, participants are presented with an ethical scenario where either a peer or advisor engages (...) in misconduct, and positive and the negative consequences of whistleblowing are either directed to the wrongdoer, department, or university. Participant responses to case questions were evaluated for whistleblowing intentions, moral intensity, metacognitive reasoning strategies, and positive and negative, active and passive emotions. Findings indicate that participants were less likely to report the observed misconduct of an advisor compared to a peer. Furthermore, the findings also suggest that when an advisor is the source of misconduct, greater negative affect results. Post-hoc analyses were also conducted examining the differences between those who did and did not intend to blow the whistle under the circumstances of either having to report an advisor or peer. The implications of these findings for understanding the complexities involved in whistleblowing are discussed. (shrink)

BackgroundChildhood adversity is linked to adverse health in adulthood. One posited mechanistic pathway is through physiological responses to acute stress. Childhood adversity has been previously related to both exaggerated and blunted physiological responses to acute stress, however, less is known about the psychological mechanisms which may contribute to patterns of physiological reactivity linked to childhood adversity.ObjectiveIn the current work, we investigated the role of challenge and threat stress appraisals in explaining relationships between childhood adversity and cortisol reactivity in response to (...) an acute stressor.MethodsUndergraduate students completed an online survey that included general demographic information and the Risky Families Questionnaire 24 h before a scheduled lab visit. In the lab, a research assistant collected a baseline salivary cortisol sample. Following the baseline period, participants were read instructions for the Trier Social Stress Test, a validated psychological lab stressor. Next, they completed a challenge vs. threat task appraisal questionnaire and completed the speech and math portion of the TSST. Twenty minutes following the start of the TSST, a second salivary sample was collected to measure changes in salivary cortisol following the TSST.ResultsLinear regression analyses adjusted for age, sex, childhood socioeconomic status, and baseline cortisol levels, showed childhood adversity associated with changes in cortisol levels [B = –0.29 t = –2.35, p = 0.02, R2=0.07]. Linear regression analyses controlling for age, sex, and childhood SES showed childhood adversity associated with both challenge [B = –0.52 t = –5.04, p < 0.001, R2=0.24] and threat [B = 0.55 t = 5.40, p < 0.001, R2=0.27] appraisals. Significant indirect effects of childhood trauma on cortisol reactivity were observed through challenge appraisals [B = –0.01 ], and threat appraisals [B = –0.01 ].ConclusionChildhood adversity may contribute to blunted cortisol reactivity, a pattern of response which is linked to obesity, addiction, and other behavior-related diseases. Our findings suggest that this relationship is in part a product of stress appraisals. (shrink)

This essay asks: How do the realities of embodied trauma inflicted by racism interface with virtue theory? This question illuminates two lacunae in virtue theory. The first is attention to race. We argue that the contemporary academic virtue literature performs largely as a White space, failing to address virtue theory’s role in the social construction of race, ignoring the rich and vibrant resources on virtue ethics alive within the Black theological tradition that long antedates Alasdair MacIntyre’s After Virtue, and segregating (...) the emerging literature on race and virtue from the broader discourse. The second is lack of attention to embodiment. More precisely, contemporary virtue theory, informed largely by Aristotle, Aquinas, and MacIntyre, has no conceptual space to theorize the body’s role acquiring and deploying virtue and vice. To explore this nexus, we draw on racial trauma therapist Resmaa Menakem, Katie Walker Grimes, and Howard Thurman’s Jesus and the Disinherited to challenge contemporary virtue theory and open new possibilities for a robustly corporate, enfleshed theological virtue ethic. (shrink)

ABSTRACT Research examining ethical decision-making has focused on how people engage in EDM, leading many researchers to focus on sensemaking models of EDM. Although the merits of a sensemaking approach with respect to EDM are evident in the literature, less is known about the specific cognitive processes by which sensemaking impacts EDM. This study examines the impact of three late-cycle cognitive processes – idea generation, evaluation, and revision – as well as the timing of these processes on EDM. Results indicate (...) that information gathering early on is critical to EDM; a finding which supports an active sensemaking model over an intuitive one. (shrink)

ABSTRACT Prior studies have examined the impacts of sensemaking processes, such as forecasting, on ethical decision making but only a few have considered how aspects of the ethical issue itself, such as social consensus and magnitude of consequences, might interact with sensemaking processes to influence EDM. The present effort examines both forecasting and moral intensity, as well as their interactions, during the EDM process. Participants in this study were given an ethical scenario with either a high or low degree of (...) social consensus as well as a greater or smaller magnitude of consequences. They were then asked to forecast either many or few potential outcomes stemming from their actions before coming up with a final plan of action. Responses were rated for quality of forecasting, use of metacognitive reasoning strategies, perceived moral intensity, and ethicality. Results indicate that social consensus may not be beneficial for EDM if the magnitude of consequences is low or individuals are not engaged in extensive forecasting. Implications of these findings are discussed. (shrink)

Randomized controlled trial trial designs exist on an explanatory-pragmatic spectrum, depending on the degree to which a study aims to address a question of efficacy or effectiveness. As conceptualized by Schwartz and Lellouch in 1967, an explanatory approach to trial design emphasizes hypothesis testing about the mechanisms of action of treatments under ideal conditions, whereas a pragmatic approach emphasizes testing effectiveness of two or more available treatments in real-world conditions. Interest in, and the number of, pragmatic trials has grown substantially (...) in recent years, with increased recognition by funders and stakeholders worldwide of the need for credible evidence to inform clinical decision-making. This increase has been accompanied by the onset of learning healthcare systems, as well as an increasing focus on patient-oriented research. However, pragmatic trials have ethical challenges that have not yet been identified or adequately characterized. The present study aims to explore the views of key stakeholders with respect to ethical issues raised by the design and conduct of pragmatic trials. It is embedded within a large, four-year project that seeks to develop guidance for the ethical design and conduct of pragmatic trials. As a first step, this study will address important gaps in the current empirical literature with respect to identifying a comprehensive range of ethical issues arising from the design and conduct of pragmatic trials. By opening up a broad range of topics for consideration within our parallel ethical analysis, we will extend the current debate, which has largely emphasized issues of consent, to the range of ethical considerations that may flow from specific design choices. Semi-structured interviews with key stakeholders, across multiple jurisdictions, identified based on their known experience and/or expertise with pragmatic trials. We expect that the study outputs will be of interest to a wide range of knowledge users including trialists, ethicists, research ethics committees, journal editors, regulators, healthcare policymakers, research funders and patient groups. All publications will adhere to the Tri-Agency Open Access Policy on Publications. (shrink)

The aim of this paper is to provide an overview of various forms of alethic pluralism. Along the way we will draw a number of distinctions that, hopefully, will be useful in mapping the pluralist landscape. Finally, we will argue that a commitment to alethic disjunctivism, a certain brand of pluralism, might be difficult to avoid for adherents of the other pluralist views to be discussed. We will proceed as follows: Section 1 introduces alethic monism and alethic pluralism. Section 2 (...) presents a distinction between strong and moderate versions of monism and pluralism, understood as theses about the existence of truth properties. Section 3 introduces four pluralist positions: strong alethic pluralism, alethic disjunctivism, second-order functionalism and manifestation functionalism. These positions are classified using the basic framework from Section 2, and a further distinction between pure and mixed versions of pluralism is drawn. Interestingly, alethic disjunctivism and the two kinds of functionalism—i.e. three out of four positions— have a mixed character. They incorporate a monist thesis. The only pure form of pluralism is strong alethic pluralism. Section 4 adds another distinction to the stock: one-level and two-level views. Each of the mixed positions operates with two levels, locating certain “alethically potent”—or grounding—properties at a lower level and others at a higher level. We briefly discuss the nature of grounding. In Section 5, we answer a question about mixed, two-level views, viz. whether they are as much monist as pluralist in nature, or more. They are not. Section 6 is devoted to the task of arguing that the strong pluralist, the second-order functionalist, and the manifestation functionalist will find it hard to deny a commitment to alethic disjunctivism. (shrink)

A collection of previously published articles and essays.

L'idée que la concentration géographique est essentielle au processus d'innovation est largement admise. Or, ce lien n'est pas clairement établi et il convient de réinterroger les relations entre communication, localisation et processus d'innovation. Cet article s'attache à le faire en privilégiant une entrée par les dynamiques de proximité, c'est-à-dire par la question de la coordination des acteurs. Nous identifions dans un premier temps le rôle de la proximité entre les différentes parties prenantes du processus d'innovation. Nous proposons ensuite une typologie (...) de la diversité des configurations spatiales de l'innovation en tenant compte du jeu dynamique des proximités.The idea that geographic concentration is essential to the process of innovation is widely recognized. However, this relationship is not clear and should re-examine the relationship between communication, location and process innovation. This article attempts to do so by favoring entry dynamics proximity, that is to say, by the issue of coordination of the actors. We identify firstly the role of proximity between the various stakeholders in the innovation process. We then propose a typology of the diversity of spatial patterns of innovation taking into account the dynamic interplay of proximity. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Metaphysical Themes in Thomas Aquinas III by John F. WippelTherese Scarpelli CoryWIPPEL, John F. Metaphysical Themes in Thomas Aquinas III. Washington, D.C.: The Catholic University of America Press, 2021. ix + 321 pp. Cloth, $65.00; eBook, $65.00This volume is the third in what can now be considered informally a series of volumes collecting some of John F. Wippel's most important writings. (Two previous volumes, Metaphysical Themes in Thomas (...) Aquinas and Metaphysical Themes in Thomas Aquinas II, were published in 1984 and 2007, respectively, by the same press.) In this volume, Wippel has collected nine of his articles or book chapters, originally published from 2002–2019, on a wide range of topics: (1) "Aquinas on Separatio and Our Discovery of Being as Being," (2) "Thomas Aquinas on Philosophy and the Preambles of Faith," (3) "Cornelio Fabro on the Distinction and Composition of Essence and Esse in the Metaphysics of Thomas Aquinas," (4) "Cornelio Fabro on Participation and Aquinas's Quarta Via," (5) "Aquinas on Creation and Preambles of Faith," (6) "Thomas Aquinas and the Unity of Substantial Form," (7) "Thomas Aquinas on the Separated Soul's Natural Knowledge," (8) "Metaphysical Themes in De Malo I," and (9) "Metaphysical Composition of Angels in Bonaventure, Aquinas, and Godfrey of Fontaines."Such collections provide a valuable opportunity for the author's retrospective on the work thus collected. In this respect, it is especially worth noting the usefulness of the introduction to this volume, in which Wippel has provided a detailed précis for each included chapter. The introduction thus serves as a helpful roadmap to orient new and returning readers of Wippel's work to some of his most important writings.In a book review of this length, it is impossible to summarize adequately the content of each essay. Indeed, it would be redundant to try, given the much more authoritative content of Wippel's own introduction to the volume. Consequently, I will limit myself to highlighting one of the notable inclusions in this collection, namely, chapter 6, "Thomas Aquinas and the Unity of Substantial Form." Despite the modest title, the piece is an extensive and wide-ranging study of the development and fate of Aquinas's controversial doctrine, the anxieties it raised among his contemporaries, and the debate that raged at Paris in the late thirteenth century, and during which the doctrine appears to have narrowly escaped inclusion on the list of condemnations of 1270. Wippel correlates some interesting historical anecdotes and documentary evidence with Aquinas's series of changing formulations in discussions of the unity of substantial form. He is thereby able to document a particularly nuanced case in which Aquinas attempts to make his own thought clearer in the face of a developing controversy, but without giving up on the essentials of his own position.Nonetheless, Wippel points out that Aquinas never fully resolved the theological criticisms lodged against his position. Within the debate over the number of substantial forms in a substance, the identity of Christ's dead body in the tomb between the crucifixion and resurrection ended up becoming a test case: What makes Christ's living body and his dead body in the tomb both be identically the same body? The problem is as follows: [End Page 371] Since substantial form is what secures the identity of a substance across time, if there is just one substantial form in a human substance, and that form (the human soul) departs Christ's body in his death on the cross, then after his death whatever is left can no longer be identified as Christ's body. It must be some new substance with its own substantial form.For opponents, this difficulty was fatal. How did Aquinas respond? Disappointingly, he only asserts that Christ's dead body is numerically identical with his living body, just not "in every way"—but without explaining why he thinks this identity is preserved. It is left to Giles of Rome to fill out a tentative solution: Although the matter of Christ's body does take on a new substantial form, it remains Christ's, because it remains united to the person of the Word.The problem is... (shrink)

This paper builds upon a critically clarified statement of the triune brain concept to set out the conflict systems neurobehavioral model. The model defines the reciprocal algorithms of behavior from evolved brain structure. The algorithms are driven by subjectively experienced behavioral tension as the self‐preservational programming, common to our ancestral vertebrates, frequently tugs and pulls against the affectional program‐ming of our mammalian legacy. The yoking of the dual algorithmic dynamic accounts for the emergence of moral and spiritual consciousness as manifested (...) in the universal norm of reciprocity and in the work of such thinkersas Martin Buber and Paul Tillich. (shrink)

Cette livraison de la revue Langages semble avoir un objectif éditorial officiel, affiché dans son titre, consistant à porter un regard réflexif et critique sur les apports et les limites des (grands) corpus à divers domaines de l’analyse linguistique, et un objectif profond, moins immédiatement perceptible mais sans doute premier dans l’esprit des coordinateurs et particulièrement de Marcel Cori, consistant à remettre à sa juste place la linguistique de corpus accusée d’avoir des ambitions h...

Review of New Waves in Metaethics, edited by Michael Brady; and New Waves in Truth, edited by Cory D. Wright and Nikolaj J.L.L. Pedersen.

Cette livraison de la revue Langages semble avoir un objectif éditorial officiel, affiché dans son titre, consistant à porter un regard réflexif et critique sur les apports et les limites des (grands) corpus à divers domaines de l’analyse linguistique, et un objectif profond, moins immédiatement perceptible mais sans doute premier dans l’esprit des coordinateurs et particulièrement de Marcel Cori, consistant à remettre à sa juste place la linguistique de corpus accusée d’avoir des ambitions h..

For twenty years, the renowned philosopher of science Sandra Harding has argued that science and technology studies, postcolonial studies, and feminist critique must inform one another. In The Postcolonial Science and Technology Studies Reader, Harding puts those fields in critical conversation, assembling the anthology that she has long wanted for classroom use. In classic and recent essays, international scholars from a range of disciplines think through a broad array of science and technology philosophies and practices. The contributors reevaluate conventional accounts (...) of the West’s scientific and technological projects in the past and present, rethink the strengths and limitations of non-Western societies’ knowledge traditions, and assess the legacies of colonialism and imperialism. The collection concludes with forward-looking essays, which explore strategies for cultivating new visions of a multicultural, democratic world of sciences and for turning those visions into realities. Feminist science and technology concerns run throughout the reader and are the focus of several essays. Harding provides helpful background for each essay in her introductions to the reader’s four sections. Contributors Helen Appleton Karen Bäckstrand Lucille H. Brockway Stephen B. Brush Judith Carney Committee on Women, Population, and the Environment Arturo Escobar Maria E. Fernandez Ward H. Goodenough Susantha Goonatilake Sandra Harding Steven J. Harris Betsy Hartmann Cori Hayden Catherine L. M. Hill John M. Hobson Peter Mühlhäusler Catherine A. Odora Hoppers Consuelo Quiroz Jenny Reardon Ella Reitsma Ziauddin Sardar Daniel Sarewitz Londa Schiebinger Catherine V. Scott Colin Scott Mary Terrall D. Michael Warren. (shrink)

This paper places formal learning theory in a broader philosophical context and provides a glimpse of what the philosophy of induction looks like from a learning-theoretic point of view. Formal learning theory is compared with other standard approaches to the philosophy of induction. Thereafter, we present some results and examples indicating its unique character and philosophical interest, with special attention to its unified perspective on inductive uncertainty and uncomputability.

Originally published in 1936, this book presents the ancient Greek text of the paraphrases and quotations of Zeno's philosophical arguments, together with a facing-page English translation and editorial commentary. Detailed notes are incorporated throughout and a bibliography is also included. This book will be of value to anyone with an interest in Zeno and ancient philosophy.

The subject of the present inquiry is the approach-to-the-truth research, which started with the publication of Sir Karl Popper's Conjectures and Refutations. In the decade before this publication, Popper fiercely attacked the ideas of Rudolf Carnap about confirmation and induction; and ten years later, in the famous tenth chapter of Conjectures he introduced his own ideas about scientific progress and verisimilitude. Abhorring inductivism for its apprecia tion of logical weakness rather than strength, Popper tried to show that fallibilism could serve (...) the purpose of approach to the truth. To substantiate this idea he formalized the common sense intuition about preferences, that is: B is to be preferred to A if B has more advantages andfewer drawbacks than A. In 1974, however, David Millerand Pavel Tichy proved that Popper's formal explication could not be used to compare false theories. Subsequently, many researchers proposed alternatives or tried to improve Popper's original definition. (shrink)

From the first months of life, human infants produce “protophones,” speech-like, non-cry sounds, presumed absent, or only minimally present in other apes. But there have been no direct quantitative comparisons to support this presumption. In addition, by 2 months, human infants show sustained face-to-face interaction using protophones, a pattern thought also absent or very limited in other apes, but again, without quantitative comparison. Such comparison should provide evidence relevant to determining foundations of language, since substantially flexible vocalization, the inclination to (...) explore vocalization, and the ability to interact socially by means of vocalization are foundations for language. Here we quantitatively compare data on vocalization rates in three captive bonobo (Pan paniscus) mother–infant pairs with various sources of data from our laboratories on human infant vocalization. Both humans and bonobos produced distress sounds (cries/screams) and laughter. The bonobo infants also produced sounds that were neither screams nor laughs and that showed acoustic similarities to the human protophones. These protophone-like sounds confirm that bonobo infants share with humans the capacity to produce vocalizations that appear foundational for language. Still, there were dramatic differences between the species in both quantity and function of the protophone and protophone-like sounds. The bonobo protophone-like sounds were far less frequent than the human protophones, and the human protophones were far less likely to be interpreted as complaints and more likely as vocal play. Moreover, we found extensive vocal interaction between human infants and mothers, but no vocal interaction in the bonobo mother–infant pairs—while bonobo mothers were physically responsive to their infants, we observed no case of a bonobo mother vocalization directed to her infant. Our cross-species comparison focuses on low- and moderate-arousal circumstances because we reason the roots of language entail vocalization not triggered by excitement, for example, during fighting or intense play. Language appears to be founded in flexible vocalization, used to regulate comfortable social interaction, to share variable affective states at various levels of arousal, and to explore vocalization itself. (shrink)

This article describes the process engaged by 17 expert scholars in the development of a set of six consensus recommendations about the normative foundations of pediatric decision-making. The process began with a robust pre-reading assignment, followed by three days of in-person symposium discussions that resulted in a publication in _Pediatrics_ entitled “Pediatric Decision-Making: Consensus Recommendations” (Salter et al. 2023). This article next compares the six recommendations to existing statements about pediatric decision-making (specifically those developed by the American Academy of Pediatrics), (...) highlighting similarities and differences. Finally, the article discusses the value of finding consensus in the field of pediatric bioethics. (shrink)

In this essay, I claim that certain passages in Book IV of Benedict de Spinoza’s Ethics suggest a novel version of what is known as metaethical constructivism. The constructivist interpretation emerges in the course of attempting to resolve a tension between Spinoza’s apparent ethical egoism and some remarks he makes about the efficacy of collaborating with the right partners when attempting to promote our individual self-interest . Though Spinoza maintains that individuals necessarily aim to promote their self-interest, I argue that (...) Spinoza has an atypical conception of self that allows the interests of other people to be partially constitutive of one's own self-interest. In this way, Spinoza can account for the rationality of concern for the interests of others . This interpretation attributes to Spinoza a form of constructivism that differs in important ways from contemporary Humean and Kantian constructivisms and which can in principle be detached from Spinoza’s particular metaphysical commitments in order to yield a third general category of constructivist view . Though my treatment is necessarily brief, it is my hope that it can serve both to motivate a constructivist reading of Spinoza and, perhaps even more crucially, to suggest a Spinozistic variety of constructivism as a live theoretical option in metaethics. (shrink)

Both the concept of a Darwinian tree of life (TOL) and the possibility of its accurate reconstruction have been much criticized. Criticisms mostly revolve around the extensive occurrence of lateral gene transfer (LGT), instances of uptake of complete organisms to become organelles (with the associated subsequent gene transfer to the nucleus), as well as the implications of more subtle aspects of the biological species concept. Here we argue that none of these criticisms are sufficient to abandon the valuable TOL concept (...) and the biological realities it captures. Especially important is the need to conceptually distinguish between organismal trees and gene trees, which necessitates incorporating insights of widely occurring LGT into modern evolutionary theory. We demonstrate that all criticisms, while based on important new findings, do not invalidate the TOL. After considering the implications of these new insights, we find that the contours of evolution are best represented by a TOL. (shrink)

Antimicrobial resistance (AMR) poses an increasing threat to patient care and population health and there is a growing need for novel therapies to tackle AMR. Bacteriophage (phage) therapy is a re-emerging antimicrobial strategy with the potential to transform how bacterial infections are treated in patients and populations. Currently, in the UK, phages can be used as unlicensed medicinal products on a ‘named-patient’ basis. We make an ethical case for why it is crucially important for the UK to invest in Good (...) Manufacturing Practice (GMP) for both ongoing unlicensed and future licensed phage therapy. Access to phages produced to GMP (GMP phages) will ensure effective patient care and better outcomes as well as health systems benefits. The UK also has the potential to become a global leader in the timely and cost-efficient manufacturing and supply of a therapy that meets internationally recognised standards. (shrink)

Shaḥrūr, Muḥammad; Islamic philosophy; Qurʼan; hermeneutics; criticism, interpretation, etc.