The levels of different classes of mitochondrially encoded transcripts are developmentally regulated in sea urchin embryos, as a result of selection between mutually exclusive synthetic pathways. I propose a simple model to explain these observations, based on a dual role for mitochondrial ribosomes and translation factors in RNA synthesis as well as in translation. This effect may be exerted either at the transcriptional or post‐transcriptional level (or both), and is potentially generalizable to mammalian mtDNA and to other systems.

Last year, we reported a new mechanism of DNA replication in mammals. It occurs inside mitochondria and entails the use of processed transcripts, termed bootlaces, which hybridize with the displaced parental strand as the replication fork advances. Here we discuss possible reasons why such an unusual mechanism of DNA replication might have evolved. The bootlace mechanism can minimize the occurrence and impact of single‐strand breaks that would otherwise threaten genome stability. Furthermore, by providing an implicit mismatch recognition system, it should (...) limit the occurrence of replication‐dependent deletions and insertions, and defend against invading elements. Such a mechanism may also limit attempts to manipulate the mammalian mitochondrial genome. (shrink)

To sum up on forms and rightness. No one wants poetry to be like filling out a form, though plenty of poems look dismally like it. The forms were there to be wrestled with mightily, because they silently and emptily, till one filled them up with the thing said, stood for the recalcitrant outside and other that knows nothing of the human will. The mindless rigidity in principle of the verse patterns suggestively compounded with the sinewy nature of the speaking (...) voice that flowed in continuous energy through the marked-off graph of foot and line and strophe. Together they might be taken to stand for two powers of the mind that ought to work with and against one another to the same effect: the streamy nature of association, said Coleridge, that thinking curbs and rudders. Ezra Pound's commandment to the poet, to compose in the sequence of the musical phrase, not in the sequence of the metronome, is a good warning against monotonous cadences; but taken literally it invites the reply that Beethoven did both. For art is a place where you make choices, sometimes difficult ones that require you decide not between good and bad but between this good and that: very often it is between the beauty of a line and the sense of the whole thing. A proverb says you can't do two things at once; but it is conspicuous that in art you must always be doing two things at once, knowing that that is only the minimum requirement: And twofold Always. May God us keepFrom Single vision & Newton's sleep! Howard Nemerov, professor of English at Washington University, is the author of, among other works, Figures of Thought: Speculations on the Meaning of Poetry and Other Essays and The Collected Poems, for which he received the National Book Award and the Pulitzer Prize for poetry in 1978. See also: "Strict Form in Poetry: Would Jacob Wrestle with a Flabby Angel" by Peter Viereck in Vol. 5, No. 2. (shrink)

The history of physics ranges from antiquity to modern string theory. Since early times, human beings have sought to understand the workings of nature--why unsupported objects drop to the ground, why different materials have different properties, and so forth. The emergence of physics as a science, distinct from natural philosophy, began with the scientific revolution of the 16th and 17th centuries when the scientific method came into vogue. Speculation was no longer acceptable; research was required. The beginning of the 20th (...) century marks the start of a more modern physics. Physicists began to study the atom, with its electrons and its nucleus. Then they began to look at the fundamental question of the forces that hold the nucleus together and the particles that account for the natural forces. This book approaches the history of physics from a biographical point of view, considering people to be more interesting than things, and the combination of the two more interesting than the sum of the individual parts. After a brief overview of classical and modern physics, 336 one-page biographies of individuals who have made significant contributions to the field of physics are presented. (shrink)

Poetry doesn't write about what it writes about. Critics may now agree that this tends to be so, but why? Is it, as here argued, inherently so because of poetry's two or more rhythm-levels? Or is it, as many "explicating" critics imply, noninherently and only recently so because of the two or more diction-levels of the symbolist heritage? If the answer to the latter question is no, then the explicators have brought us to a blind alley by being oversubtle about (...) the ambiguities and ambivalences of diction and undersubtle about those of rhythm. The fact that good prose also has two rhythm-levels is not to the point. The tension between two irregular rhythms, as in prose, is simply not the same as that between one irregularity and one formal, traditionally shared regularity in poetry. The half-conscious uncovering of rhythm's hidden language helps explain an ancient truth: unlike a prose essay, a tragic poem or a tragic verse-play may leave the reader feeling exalted while an exalting love poem may leave him mournful. The explanation is not some miraculous "transcending" of tragedy and of the human condition but the uncovering of a palimpsest layer. What will be needed, from now on, are not generalizations but precise trochee-by-iamb-by-spondee analyses of why the relevant passages in King Lear, for example, achieve tragic joy by means of the joy-connoting rhythms beneath the somber words. While translating certain German and Russian poets of our century, I am also making a parallel analysis in parallel languages. My conclusion: the future translator should consult his dictionary less and his ear more . Poets, then, are not our Shelleyan "unacknowledged legislators" but our unacknowledged kinaesthesia. Peter Viereck, professor of European and Russian history at Mount Holyoke College, received the Pulitzer Prize for his book of poems, Terror and Decorum ; this and his Conservatism Revisited and The Unadjusted Man have recently been reprinted by Greenwood Press. In a slightly revised version, "Strict Form in Poetry" appears as the appendix in his book of poems, Applewood, for which he has been awarded a fellowship by the Artists Foundation. See also: "On the Measure of Poetry" by Howard Nemerov in Vol. 6, No. 2. (shrink)

Michael Walzer has made great contributions to the appreciation of both moral and cultural pluralism in political theory. Nonetheless, there are ways in which Walzer's arguments appear anti-pluralistic. The question of this essay is: why is there so little pluralism in Walzer's political theory, or why does its pluralism run out so soon? Focusing on Spheres of Justice and Nation and Universe, it examines the effect of Walzer's nationalism/statism on his theory, and the constraints his theory faces in considering multiculturalism (...) or political pluralist regimes such as federalism within a state. (shrink)

Colonialism and Its Legacy brings together essays by leading scholars in both the fields of political theory and the history of political thought about European colonialism and its legacies, and postcolonial social and political theory. The essays explore the ways in which European colonial projects structured and shaped much of modern political theory, how concepts from political philosophy affected and were realized in colonial and imperial practice, and how we can understand the intellectual and social world left behind by a (...) half-millennium of European empires. (shrink)

Abstract:In this essay, I argue against the bright-line distinction between ideal and nonideal normative political theory, a distinction used to distinguish “stages” of theorizing such that ideal political principles can be deduced and examined before compromises with the flawed political world are made. The distinction took on its familiar form in Rawls and has enjoyed a resurgence of interest in the past few years. I argue that the idea of a categorical distinction — the kind that could allow for a (...) sequencing of stages of theorizing — is misconceived, because wholly “ideal” normative political theory is a conceptual mistake, the equivalent of taking the simplifying models of introductory physics (“frictionless movement in a vacuum”) and trying to develop an ideal theory of aerodynamics. Political organization and justice are about moral friction in the first instance. I examine both logical and epistemological arguments for the position that we need the uniquely idealizing assumptions of ideal theory in order to arrive at, or to know, a genuine theory of justice or political morality; and I find them wanting. Such assumptions as full compliance, consensus, and the publicity principle of universal knowledge about consensus can sometimes be useful, if used carefully and with justification; but they are not categorically different from other idealizing and abstracting assumptions in generating normative theory. What is referred to as “nonideal” theory is all that there is, and it is many kinds of theory, not one — the many ways in which we learn about justice and injustice, and seek to answer questions of practical reason about what ought to be done in our political world. (shrink)

This book offers an original account of the history of liberal thought, one grounded in an institutional history of medieval pluralism and the early modern rationalizing state, and explores the deep tensions that liberal political thought rests upon.

This article diagnoses and critiques pervasive forms of teleological thought about basic structures of political organization in modern and contemporary political thought: arguments that the sovereign state, the nation-state, or some variant of a cosmopolis both represents the unfolding of history’s moral logic and offers us full moral personhood, agency, and maturity. Despite the received wisdom that modern political thought broke with teleology, I argue that early modern social contract theory was deeply teleological. The emergence of the normatively self-contained sovereign (...) state from the state of nature represented both decisive historical-moral progress from the medieval European non-state polities and the possibility of true moral personhood, thanks to the unity of will and judgment created by a unified authority structure. The article then argues that this overattachment to unity, both as an historical culmination and as a prerequisite to full personhood, was carried over into subsequent nationalist and cosmopolitan thought, where we see over-moralizations of historical processes, excessive claims for the teleological causal force of moral progress, and critiques of the immaturity of those persons who do not live in the recommended political form. The article closes with a sustained critique of both historical and individual-moral teleologies of these sorts. (shrink)

Abstract The liberalism of fear urged by Judith Shklar emphasizes the dangers of political violence, cruelty, and humiliation. Those dangers clearly mark ethnic and cultural conflicts, so the liberalism of fear is an especially appropriate political ethic for an age marked by such conflicts. A multiculturalism of fear keeps its attention on those central political dangers while also noting that some kinds of cruelty and humiliation might not be appreciated without reference to the larger ethnic and cultural context, and that (...) treating ethnicity and culture as completely outside of politics is not the best way to prevent cruelty. (shrink)

The political theory literature on multiculturalism is dominated by approaches based on rights and recognition -- quintessentially 17th- and 19th-century concepts, respectively. In this paper I aim to complement those approaches with one drawing on the 18th-century concept of manners. A range of cases of cultural contact and conflict -- especially those in the up-close settings of city life, and especially those having to do with contrasting cultural norms about seeing and being seen -- do not admit of wholly satisfactory (...) resolutions in which every morally legitimate claim can be met at the same time. The paper surveys such cases, and explains what the concepts of manners and civility can bring to bear on their analysis. (shrink)

This article diagnoses and critiques pervasive forms of teleological thought about basic structures of political organization in modern and contemporary political thought: arguments that the sovere...

Social contract theory imagines political societies as resting on a fundamental agreement, adopted at a discrete moment in hypothetical time, that both bound individual persons together into a single polity and set fundamental rules regarding that polity's structure and powers. Written constitutions, adopted at real moments in historical time, dictating governmental structures, bounding governmental powers, and entrenching individual rights, look temptingly like social contracts reified. I argue in this article, however, that something essential is lost in the casual slippage between (...) social contract theory and the practice of constitutionalism. Enacted constitutions do not come into being against the background of a state of nature of isolated individuals; and by this I do not mean to invoke the too-familiar critique of the supposedly decontextualized liberal person, but rather to critique the aspiration to decontextualize the legal and political order. Constitutions are enacted in ongoing societies (whether newly politically sovereign or otherwise) with pre-existing laws and legal systems, political organizations, cultural and linguistic and religious divisions, and norms and mores. Moreover, the practice of constitutionalism is usually, at least in part, a practice of reconciling those legacies to a new political order, of making use of those legacies to build loyalties to or counterbalances against the state (or both). Most constitutions cannot be well-understood by retrospectively characterizing them as the kind of complete and radical break with the past envisioned by social contract theory. Contractarian blinders lead us to look for greater individualism, greater social unity, and greater coherence of principles than can actually be expected of constitutions or constitutionalism. Real constitutional orders appropriate, incorporate, and channel the histories and divisions of the societies they govern. Treating them as if they are social contracts will flatten and distort them, making those engagements with the past or with social plurality appear anomalous and encouraging their minimization. I aim to redirect some of our attention to non-contractarian constitutionalism, or non-contractarian strands within constitutionalism, both as intellectual inheritance and as lived practice. Non-contractarian elements persisted in constitutional theory across the apparent break of the late 1700s, even though these have to some degree been lost sight of more recently; and they have persisted and should persist in constitutional practice. (shrink)

U.S. Department of Health and Human Services (HHS) federal regulations pertaining to the protection of human subjects at Title 45 of the Code of Federal Regulations, Part 46, Subpart A (“the Common Rule”), refer to the need for special precautions when persons characterized as vulnerable are used as human research subjects. Under the Common Rule, persons considered “vulnerablae” are those who are likely to be susceptible to coercive or undue influence; the term “vulnerable” includes “children, prisoners, pregnant women, mentally disabled (...) persons,” or those who are “economically or educationally disadvantaged.” The need for special precautions with some of these vulnerable persons in the context of research has long been addressed by both mandatory additional protections found in Subparts B through D of 45 C.F.R. pt. 46 (that arenot, coincidentally, part of the Common Rule) and additional detailed guidance documents provided by HHS or its components to investigators and their respective institutions. (shrink)

clusions are only probably correct. On the other hand, algorithmic information theory provides a precise mathematical definition of the notion of random or patternless sequence. In this paper we shall describe conditions under which if the sequence of coin tosses in the Solovay– Strassen and Miller–Rabin algorithms is replaced by a sequence of heads and tails that is of maximal algorithmic information content, i.e., has maximal algorithmic randomness, then one obtains an error-free test for primality. These results are only of (...) theoretical interest, since it is a manifestation of the G¨ odel incompleteness phenomenon that it is impossible to “certify” a sequence to be random by means of a proof, even though most sequences have this property. Thus by using certified random sequences one can in principle, but not in practice, convert probabilistic tests for primality into deterministic ones. (shrink)

In this article, part of a symposium on David Miller's Global Justice and National Responsibility, I first focus on an area of disagreement: Miller‘s attempt to attribute to nations responsibility that I think ought to be generally attributed to states. I then sketch a theory that disregards nations more or less completely, and yet issues in a two-level theory like Miller‘s, sanctioning important differences between intrastate and interstate distribution. It is only like Miller‘s, because the distinction between states and nations (...) is one with a very real difference indeed. Moreover, I think that Miller aims to build up the moral and historical prestige of the nation-state to make it a viable competitor with the claims of universal morality, whereas I will engage in a kind of deflation that teaches us not to expect contingent forms of political organization to instantiate great moral truths. But this results in an account that is perhaps more like his than either is like cosmopolitanism visions, whether egalitarian or libertarian. (shrink)

Social contract theory imagines political societies as resting on a fundamental agreement, adopted at a discrete moment in hypothetical time, that binds individual persons together into a polity and sets fundamental rules regarding that polity's structure and powers. Written constitutions, adopted at real moments in historical time, dictating governmental structures, bounding governmental powers, and entrenching individual rights, look temptingly like social contracts reified. Yet something essential is lost in this slippage between social contract theory and the practice of constitutionalism. Contractarian (...) blinders lead us to look for greater individualism, social unity, and coherence of principles than should be expected. Real constitutional orders appropriate, incorporate, and channel the histories and divisions of the societies they govern. Treating them as social contracts flattens and distorts them, making those engagements with the past or with social plurality appear anomalous and encouraging their minimization. Accordingly this article redirects attention to non-contractarian strands within constitutionalism's intellectual inheritance and lived practice. (shrink)

Moral uncertainty and disagreement pervade our lives. Yet we still need to make decisions and act, both individually and politically. So, what should we do? Moral uncertainty theorists provide a theory of what individuals should do when they are uncertain about morality. Public reason liberals provide a theory of how societies should deal with reasonable disagreements about morality. They defend the public justification principle: state action is permissible only if it can be justified to all reasonable people. In this article, (...) we bring these two approaches together. Specifically, we investigate whether considerations of moral uncertainty support public reason liberalism: given moral uncertainty, should we favor public justification? We argue that while moral uncertainty theory cannot vindicate an exceptionless public justification principle, it supports adopting public justification as a pro tanto principle – albeit one that can be overridden when the moral stakes are high. It also provides new answers to some intramural debates among public reason liberals and new responses to some common objections. (shrink)

For most of the century and a half that began roughly with the later works of John Stuart Mill, the most important divide within liberal political thought was that between classical liberalism and welfare liberalism. The questions that were important to the socialist/liberal debate also became important for debates within liberalism: What is the relationship between property and freedom? Between free trade and freedom? Is freedom of commercial activity on a moral par with other sorts of freedom? Is the alleviation (...) of poverty or material need a more important political goal than freedom? How do freedom and equality fit together in a liberal understanding of justice? What degree of state economic planning, or state taxation and expenditure, is compatible with liberal freedom? (shrink)

We discuss our surgical philosophy concerning the subtle interplay between the size of the surgical margin taken and the resultant morbidity from ablative oncological. procedures, which is ever more evident in the treatment of head and neck malignancy. The extent of tissue resection is determined by the "trade off" between cancer control and the perioperative, functional and aesthetic morbidity and mortality of the surgery. We also discuss our dilemmas concerning recent minimally invasive endoscopic microsurgical. techniques for the trans-oral laser removal. (...) or co-ablation of aero-digestive tract tumours, which result in a minimal. surgical margin of oncological clearance. By a process of inductive argument as to the nature of the surgical margin, we consider whether the risks of taking a lesser margin with adjuvant therapy is justified by the attendant gain in reduced surgical morbidity and the possible costs in tumour control. (c) 2006 Elsevier Ltd. All rights reserved. (shrink)

Social aspects of science and technology; collection of articles.

The transition from a relatively federal to a relatively centralized constitutional structure in the United States has often been identified with the shift from classical to welfare liberalism as a matter of public philosophy. This article argues against that distinction. The liberal argument for federalism is a contingent one, built on approximations, counterbalancing, and political power. A more federalist constitution is not automatically a freer one on classical liberal understandings of freedom. Neither is a more centralized constitution automatically a better (...) match with the ideals of welfare liberalism. The article sketches a constitutional history of federalism from the founding, through an era in which centralization was aligned with skepticism about liberal constitutionalism (for both meanings of liberal), to an era in which centralization was aligned with increases in liberal freedom (for both meanings of liberal). (shrink)

Routledge is now re-issuing this prestigious series of 204 volumes originally published between 1910 and 1965. The titles include works by key figures such as C.G. Jung, Sigmund Freud, Jean Piaget, Otto Rank, James Hillman, Erich Fromm, Karen Horney and Susan Isaacs. Each volume is available on its own, as part of a themed mini-set, or as part of a specially-priced 204-volume set.

The thesis that republicanism was only suited for small states was given its decisive eighteenth-century formulation by Montesquieu, who emphasized not only republics' need for homogeneity and virtue but also the difficulty of constraining military and executive power in large republics. Hume and Publius famously replaced small republics' virtue and homogeneity with large republics' plurality of contending factions. Even those who shared this turn to modern liberty, commerce and the accompanying heterogeneity of interests, however, did not all agree with or (...) know about Publius' institutional responses to the problems of executive and military power. Throughout the late eighteenth and early nineteenth centuries, and on both sides of the Atlantic, it remained a live question whether large states could be stable moderate republics, with responses ranging from embraces of Montesquieuian limited monarchy, to denials that there was any real large-republic problem at all, with a variety of institutional solutions in between for those who thought there was a real but soluble large-republic problem. (shrink)

In what is clearly an important development related to research integrity and the protection of human research subjects, the U.S. government has instituted two new training requirements as a condition of receiving federal financial support. First, the National Institutes of Health is requiring, as a condition of funding, that key research personnel involved in human subject research complete education “in the protection of human subjects.” Evidence that key personnel have completed this training must be provided in NIH grant applications or (...) contract proposals.The NIH education policy will eventually be superseded by a more broadly applicable instructional policy for the “responsible conduct of research,” which will be promulgated by the Department of Health and Human Service's Office of Research Integrity and the Public Health Service. The instructional policy will apply to all persons engaged in any research or research training with PHS support. Presently, the only version of the policy is in draft form. (shrink)