Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala (...) and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p <.025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology. (shrink)

On one hand, Chinese consumers are well known for conspicuous consumption and the adoption of luxury products and named brands. On the other hand, they also have a bad reputation for buying counterfeit products. Their simultaneous preferences for two contrasting types of product present a paradox that has not been addressed in the literature. This study attempts to present an explanation of this paradox by examining the effects of traditional Chinese cultural values and consumer values on consumers’ deontological judgment of (...) pirated CDs and the amount of social benefits they perceive they gain from them. We interviewed 300 Hong Kong Chinese consumers, and found that face consciousness increased materialism and risk aversion, thereby producing a favorable deontological judgment of pirated CDs. Face consciousness also has a direct effect on the amount of social benefits perceived in pirated CDs. Both favorable deontological judgment and perceived social benefits contributed to a strong intention to buy pirated CDs. The results are discussed in a cultural perspective. (shrink)

En este trabajo presento un estudio sobre el estado del arte de la llamada ‘epistemología de las simulaciones computacionales’. En particular, me centro en los varios trabajos de Eric Winsberg quién es uno de los filósofos más fructíferos y sistemáticos en este tema. Además de analizar la obra de Winsberg, y basándome en sus trabajos y en el de otros filósofos, mostraré que hay buenas razones para pensar que la epistemología tradicional de la ciencia no es suficiente para el (...) análisis de las simulaciones computacionales. (shrink)

L’article s’interroge sur la notion d’autorité et plus précisément sur les paradoxes constitutifs de l’autorité. Il commence par décrire le contexte actuel de « la crise de l’autorité » pour mettre en évidence la tension fondamentale entre autorité et liberté. Il analyse ensuite cette tension, d’abord en proposant une traversée de la notion d’autorité chez H.G. Gadamer et M. Horkheimer, puis en envisageant ses implications éthiques (l’autonomie décentrée). Il propose enfin une réflexion sur ce qui légitime en dernière instance l’autorité (...) en y distinguant trois paradoxes constitutifs : la confiance originaire, la transmission vécue, la finalité ouverte. (shrink)

In the following article we make an analysis of the paper of the First World War in a possible “philosophy of the history” of the British historian Eric Hobsbawm. To achieve this we first give three axial arguments to defend our position that asserts that Hobsbawm developed, in a certain way, a philosophy of history. Then we move on enumerate the causes that the historian found triggered the Great War, in order to comprehend the nature and functionality of them (...) inside of his philosophy of history. We end reflecting on the meaning of the First War inside the global historical evolution, in so far as that specific strife, according to Hobsbawm, signified for mankind both progresses and regressions on various areas of the life. It was a strife that seems to simultaneously mean, therefore, a hope and a deception for the rationalistic objectives of the Enlightenment and the ends of Marxism. (shrink)

Machine generated contents note: Cajal and Consciousness: Introduction. By PEDRO C. MARIJUAN1 -- Part I. Consciousness, One Hundred Years after Textura -- Progress in the Neural Sciences in the Century after Cajal (and the Mysteries -- That Remain). By THOMAS D. ALBRIGHT, THOMAS M. JESSELL, -- ERIC R. KANDEL, AND MICHAEL I. POSNER11 -- Part II. Biological Complexity and the Emergence of Consciousness -- Consciousness, Reduction, and Emergence: Some Remarks. -- By MURRAY GELL-MANN41 -- The Epistemic Paradox of Mind (...) and Matter. By HAROLD J. MOROWITZ50 -- The Conscious Cell. BY LYNN MARGULIS55 -- Complexity and Tinkering. By FRANCOIS JACOB71 -- Consciousness, the Brain, and Spacetime Geometry. By STUART HAMEROFF. 74 -- Consciousness, the Brain, and Spacetime Geometry: An Addendum-Some -- New Developments on the Orch OR Model for Consciousness. -- By ROGER PENROSE105 -- Part III. From Primary to Higher-level Consciousness -- Consciousness: The Remembered Present. By GERALD EDELMAN111 -- Consciousness and the Binding Problem. By WOLF SINGER123 -- Cajal on Neurons, Molecules, and Consciousness. By JEAN-PIERRE CHANGEUX 147 -- A Neuronal Model of a Global Workspace in Effortful Cognitive Tasks. By -- STANISLAS DEHAENE, MICHEL KERSZBERG, AND JEAN-PIERRE -- CHANGEUX152 -- Consciousness and the Brain: The Thalamocortical Dialogue in Health and -- Disease. By RODOLFO LLINAS AND URS RIBARY166 -- The Neuroanatomy of Phenomenal Vision: A Psychological Perspective. -- ByPETRA STOERIG176 -- Co-evolution of Human Consciousness and Language. By MICHAEL A. ARBIB 195 -- From Computing with Numbers to Computing with Words-From -- Manipulation of Measurements to Manipulations of Perceptions. -- By LOTFI A. ZADEH221 -- Part IV. Closing Remarks -- Who Was Cajal? By ALBERTO PORTERA-SANCHEZ253 -- Index of Contributors259 -- Subject Index261. (shrink)

The Moral Foundations of Trust seeks to explain why people place their faith in strangers, and why doing so matters. Trust is a moral value that does not depend upon personal experience or on interacting with people in civic groups or informal socializing. Instead, we learn to trust from our parents, and trust is stable over long periods of time. Trust depends on an optimistic world view: the world is a good place and we can make it better. Trusting people (...) are more likely to give through charity and volunteering. Trusting societies are more likely to redistribute resources from the rich to the poor. Trust has been in decline in the United States for over 30 years. The roots of this decline are traceable to declining optimism and increasing economic inequality, which Uslaner supports by aggregate time series in the United States and cross-sectional data across market economies. (shrink)

Objective: There are benefits and risks of giving patients more granular control of their personal health information in electronic health record (EHR) systems. When designing EHR systems and policies, informaticists and system developers must balance these benefits and risks. Ethical considerations should be an explicit part of this balancing. Our objective was to develop a structured ethics framework to accomplish this. -/- Methods: We reviewed existing literature on the ethical and policy issues, developed an ethics framework called a “Points to (...) Consider” (P2C) document, and convened a national expert panel to review and critique the P2C. -/- Results: We developed the P2C to aid informaticists designing an advanced query tool for an electronic health record (EHR) system in Indianapolis. The P2C consists of six questions (“Points”) that frame important ethical issues, apply accepted principles of bioethics and Fair Information Practices, comment on how questions might be answered, and address implications for patient care. -/- Discussion: The P2C is intended to clarify whatis at stake when designers try to accommodate potentially competing ethical commitments and logistical realities. The P2C was developed to guide informaticists who were designing a query tool in an existing EHR that would permit patient granular control. While consideration of ethical issues is coming to the forefront of medical informatics design and development practices, more reflection is needed to facilitate optimal collaboration between designers and ethicists. This report contributes to that discussion. (shrink)

This paper examines Charles Peirce's graphical notation for first-order logic with identity. The notation forms a part of his system of "existential graphs," which Peirce considered to be his best work in logic. In this paper a Tarskian semantics is provided for the graphical system.

Ethics should guide the design of electronic health records (EHR), and recognized principles of bioethics can play an important role. This approach was adopted recently by a team of informaticists designing and testing a system where patients exert granular control over who views their personal health information. While this method of building ethics in from the start of the design process has significant benefits, questions remain about how useful the application of bioethics principles can be in this process, especially when (...) principles conflict. For instance, while the ethical principle of respect for autonomy supports a robust system of granular control, the principles of beneficence and non-maleficence counsel restraint due to the danger of patients being harmed by restrictions on provider access to data. Conflict between principles has long been recognized by ethicists and has even motivated attacks on approaches that state and apply principles. In this paper we show how using ethical principles can help in the design of EHRs by first, explaining how ethical principles can and should be used generally, and then by, discuss how attention to details in specific cases can show that the tension between principles is not as bad as it initially appeared. We conclude by suggesting further ways in which the application of these (and other) principles can add value to the ongoing discussion of patient involvement in their health care. This is a new approach to linking principles to informatics design that we expect will stimulate further interest. (shrink)

I analyzed 298 open-ended responses of undergraduate students who have been reported for cheating to the question, “What, if anything, would have stopped you from committing your act of academic dishonesty?” These responses included a few major themes: students pled ignorance of what constitutes academic dishonesty and the consequences/seriousness associated with violations; students tended to deflect blame, usually by saying that their professor could have done something differently (neutralization); students did not feel they had enough time, resources, and/or skills to (...) get the desired result without taking responsibility for this lack of time, resources, and/or skills (strain); students felt they did not manage their time well with accepting the blame for the poor time management; and that a bad grade was not an option. These data and results are discussed in relation to the extant literature on the topic. (shrink)

For nearly two decades, the process of reviewing the ethical merit of research involving human subjects has been based on the application of principles initially described in the U.S. National Commission's Belmont Report, and later articulated more fully by Beauchamp and Childress in their Principles of Biomedical Ethics. Recently, the use of ethical principles for deliberating about moral problems in medicine and research, referred to in the pejorative sense as “principlism”, has come under scrutiny. In this paper we argue that (...) these principles can provide a foundation for the source of ethical appraisal of human research, but are not themselves wholly adequate for this purpose. Therefore, we further propose that (1) principles should be understood as heuristics that can be “specified” as described by DeGrazia (1992), and (2) that the principle‐based approach should be supplemented by formally incorporating “sensitivity to context” into the evaluation of clinical trials. (shrink)

For nearly two decades, the process of reviewing the ethical merit of research involving human subjects has been based on the application of principles initially described in the U.S. National Commission's Belmont Report, and later articulated more fully by Beauchamp and Childress in their Principles of Biomedical Ethics. Recently, the use of ethical principles for deliberating about moral problems in medicine and research, referred to in the pejorative sense as “principlism”, has come under scrutiny. In this paper we argue that (...) these principles can provide a foundation for the source of ethical appraisal of human research, but are not themselves wholly adequate for this purpose. Therefore, we further propose that (1) principles should be understood as heuristics that can be “specified” as described by DeGrazia (1992), and (2) that the principle‐based approach should be supplemented by formally incorporating “sensitivity to context” into the evaluation of clinical trials. (shrink)

In support of the thesis that colours are examples of metaphysical simples, this article critiques arguments to the contrary. It is shown that facts about colour resemblance do not entail the complexity of colour, for such facts may explained by recourse to acts of seeing-as. The logic of colour and colour terms is adumbrated in support of this and used in a positive argument for the claim that colours are simple.

Recently, the US has joined many European jurisdictions in extending civil marriage to same sex as well as different sex dyads. Many liberals regard this as a development worth entrenching. But a prominent recent liberal challenge to civil marriage claims otherwise. According to this challenge, by defining and conferring civil marriage, the state privileges some relationships over others that serve equally well the important liberal goal of fostering effective liberal citizenship, in violation of a prominent interpretation of the doctrine of (...) state neutrality. Theorists who press this challenge, such as Elizabeth Brake and Tamara Metz, argue that it can be met effectively only by dismantling civil marriage and replacing it with more inclusive state-maintained arrangements. So far, prominent responses to this neutralist challenge to civil marriage have focused on the special value of either the relationships to which civil marriage currently extends, or the special value of civil marriage itself. In this article, I develop an alternative reply to this neutralist challenge to civil marriage, one focusing instead on the special vulnerabilities of some of the liberally valuable relationships to which civil marriage currently extends, amorous caregiving dyads. (shrink)

The problematic Sui-dynasty catalog Lidai sanbao ji 歷代三寶紀 is well known for its many incorrect translator attributions for early canonical Chinese Buddhist texts, attributions that in large measure were accepted by the later tradition and which have remained in place even within modern editions of the Chinese Buddhist canon. The question of how its compiler Fei Changfang 費長房 arrived at his information—and whether he acted in good or bad faith in presenting it—has long been debated. Recent scholarship has argued that (...) patterns in how the Lidai sanbao ji draws from earlier sources demonstrate that Fei Changfang engaged in a deliberate manipulation of his data. This essay, in contrast, introduces manuscripts from Dunhuang of earlier and otherwise lost catalogs of Chinese Buddhist texts to demonstrate that these patterns can be explained in other ways. More broadly, it is suggested that the errors of the Lidai sanbao ji should be understood not as the products of a solitary forger, but as a sign of a wider loss of literary historical consciousness that impacted Chinese Buddhism between ca. 550–650 CE. (shrink)

Aggressive medical and surgical interventions have not been clearly demonstrated to improve survival in neonates with trisomy 18; there are no data that demonstrates improved quality of life for these children after these interventions; and these interventions are clearly associated with significant morbidity, resource allocation, and cost.

Philosophy has long struggled to understand the nature of color. The central role color plays in our lives, in visual experience, in art, as a metaphor for emotions, has made it an obvious candidate for philosophical reflection. Understanding the nature of color, however, has proved a daunting task, despite the numerous fields that contribute to the project. Even knowing how to start can be difficult. Is color to be understood as an objective part of reality, a property of objects with (...) a status similar to shape and size? Or is color more like pain, to be found only in experience and so somehow subjective? Or is color more like what some have said about time--that it seems real until we reflect enough, where we come ultimately to dismiss it as mere illusion? If color is more like shape and size, can we give a scientific account of it? Various strategies exist for this option--taking the color of an object to be just a complicated texture of that object, one that reflects certain wavelengths. Or perhaps color is merely a disposition to cause experiences in us, as salt has a disposition to dissolve. On the other hand, if color is more like pain, and found only in subjective experience, what is the nature of color experience? How, for instance, does an experience of red differ from an experience of blue, or from an experience of pain for that matter? Finally, if color is mere illusion, how do we continue to be so taken in by that illusion and how can something unreal seem so real and important to us? (shrink)

Consider manipulation in which one agent, avoiding force, threat, or fraud mobilizes some non-concern motive of another so as to induce this other to behave or move differently than she would otherwise have behaved or moved, given her circumstances and her initial ranking of concerns. As an instance, imagine that I get us to miss the opening of a play that I have grudgingly agreed to attend by engaging your sublimated compulsive tendency to check the stove when we are halfway (...) to the theatre. Such motive manipulation is, I take it, widely regarded as morally worrisome. If it really is morally worrisome, then we should be able to explain adequately why it is so. But existing condemnations of manipulation come up short in this regard. In this paper, I develop and defend a more plausible account of the moral status of this phenomenon. (shrink)

In the section of the Critique of Pure Reason entitled The Amphiboly of Concepts of Reflection Kant writes:Suppose that an object is exhibited to us repeatedly but always with the same intrinsic determinations . In that case, if the object counts as object of pure understanding then it is always the same object, and is not many but only one thing . But if the object is appearance, then comparison of concepts does not matter at all; rather, however much everything (...) regarding these concepts may be the same, yet the difference of locations of these appearances at the same time is a sufficient basis for the numerical difference of the object itself. Thus in the case of two drops of water we can abstract completely from all intrinsic difference , and their being intuited simultaneously in different locations is enough for considering them to be numerically different. (shrink)

This paper explores how image worship was conceptualized and represented by Chinese authors during the first four centuries of Buddhist presence in China. Previous scholarship has argued that image worship was initially seen in China as a distinctively Buddhist practice, so much so that Buddhism was even known to the Chinese as the “Religion of Images”. By examining the history of the interpretation of this term, the evolution of stories about sacred images, and the presentation of image worship in debates (...) about the compatibility of Buddhism with Chinese culture, I will argue that image worship was first seen as a distinctly Buddhist or non-Chinese practice only in the late fifth century. Ironically, image worship came to be seen or represented as “foreign” only long after it had already become part of most forms of Chinese religion. (shrink)

Only a small proportion of academically dishonest students ever receive an official report of academic dishonesty, and the sociology of deviance literature is ripe with studies illustrating disproportionalities in detecting, policing, and prosecuting crimes. This study addresses the degree to which disproportionalities exist in the application of relatively few official sanctions levied upon students for academic dishonesty. I compared the demographics of those who have been reported for cheating with those of an entire undergraduate student body and of self-reported cheaters (...) in the literature. I found that international students are much more likely than domestic students to get reported. (shrink)

The use of torture for interrogational purposes is frequently justified by a ‘ticking-bomb’ case, claiming that serious harms will come to a large group of people if a suspect is not tortured for the location of the bomb. In this paper, I will argue that an important recent defense of interrogational torture (Seumas Miller’s) faces several practical and epistemological problems. In this paper, I argue that these epistemological problems lead to the failure of Miller’s argument. I also argue that a (...) minimalist conception of epistemological duties gives us further reason to reject both Miller’s argument and torture more generally. I conclude that arguments for torture that are based on ticking-bomb cases are bound to face an irresolvable epistemological problem, closing one of the more prominent avenues used to justify torture. (shrink)

The use of torture for interrogational purposes is frequently justified by a ‘ticking-bomb’ case, claiming that serious harms will come to a large group of people if a suspect is not tortured for the location of the bomb. In this paper, I will argue that an important recent defense of interrogational torture (Seumas Miller’s) faces several practical and epistemological problems. In this paper, I argue that these epistemological problems lead to the failure of Miller’s argument. I also argue that a (...) minimalist conception of epistemological duties gives us further reason to reject both Miller’s argument and torture more generally. I conclude that arguments for torture that are based on ticking-bomb cases are bound to face an irresolvable epistemological problem, closing one of the more prominent avenues used to justify torture. (shrink)

Central to Wilfrid Sellars ' philosophical system is his belief that science's current ontology is inadequate as it fails to provide for an acceptable account of perceptual experience. Unfortunately, this remains the most puzzling plank in his philosophy. Sellars himself argues for this position via his wellknown example of a pink ice cube and its homogeneous colour. This homogeneity, says Sellars, bars the acceptance of science's present ontology of achromatic particles, and requires the introduction of items which are truly coloured. (...) Only with such a revised and expanded ontology, with all that entails, can science adequately meet its explanatory demands. I aim here to remedy at least some of the confusions and misunderstandings this position has engendered. But I mean to take a different route from Sellars. In short, given the problems with Sellars ' views on homogeneity, I will argue for the Sellarsian conclusion as to the inadequacy of present scientific ontologies, yet without reliance on the puzzling doctrine of homogeneity. I begin then with a detailed examination of Sellars official position, indicate the trouble spots, and begin an alternative route. As I conceive things, however, the position I will sketch is still thoroughly Sellarsian, for it proceeds from premises Sellars himself has endorsed. (shrink)

Several accounts of logical truth are compared and shown to define distinct concepts. Nevertheless, conditions are given under which they happen to declare exactly the same sentences logically true. These conditions involve the variety of objects in the domain, the richness of the language, and the logical resources available. It is argued that the class of sentences declared logically true by each of the accounts depends on particularities of the actual world.