Heterochronic genes control the timing of developmental programs. In C. elegans, two key genes in the heterochronic pathway, lin-4 and let-7, encode small temporally expressed RNAs (stRNAs) that are not translated into protein. These stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3′ untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNase Dicer/DCR-1 and members of the RDE-1/AGO1 family of proteins, which are better known for their (...) roles in RNA interference (RNAi). However, stRNA function appears unrelated to RNAi. Both sequence and temporal regulation of let-7 stRNA is conserved in other animal species suggesting that this is an evolutionarily ancient gene. Indeed, C. elegans, Drosophila and humans encode at least 86 other RNAs with similar structural features to lin-4 and let-7. We postulate that other small non-coding RNAs may function as stRNAs to control temporal identity during development in C. elegans and other organisms. BioEssays 24:119–129, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

We attempt to extend the nominalistic project initiated in Hartry Field's Science Without Numbers to modern physical theories based in differential geometry.

This note is a postscript to Ramsey's 'Truth and Probability'. It replaces that article's psychological reading of subjective probability with a reading of it as a consistency condition on the theory that we act to maximise expected utility.

Summary Popular science journalism flourished in the 1860s in England, with many new journals being projected. The time was ripe, Victorian men of science believed, for an ?organ of science? to provide a means of communication between specialties, and between men of science and the public. New formats were tried as new purposes emerged. Popular science journalism became less recreational and educational. Editorial commentary and reviewing the progress of science became more important. The analysis here emphasizes those aspects of popular (...) science which have been identified by Frank Turner as ?public science? and by Thomas Gieryn as ?boundary-work?. The religious, intellectual, and utilitarian values claimed for science by editors and contributors in their tasks of persuading the public to support science and of distinguishing science from what they often called ?applied science? are discussed. These values are shown to vary among editors and, for the editors examined here, Shirley Hibberd, Henry Slack, James Samuelson, William Crookes, and Henry Lawson, to differ significantly from those of T. H. Huxley, John Tyndall, and Norman Lockyer, on whom much study of the popularization of science in the 1860s has focused. (shrink)

This book makes explicit the ecological implications of Martin Heidegger. It examines how the trajectory of Heidegger's thinking harbors an "ecological turn," which comes to the forefront in his attempt to anticipate the impending crisis precipitated by modern technology. Schalow's emphasis on such key motifs as stewardship, dwelling, and 'letting be' serves to coalesce the problem of freedom in a new and innovative way, in order to expand the interpretive or hermeneutic horizon for re-examining Heidegger's philosophy. By prioritizing a response (...) to today's environmental crisis and the possible impact upon future generations, the author traverses a divide within Heidegger scholarship by developing a deeper, critical outlook on his philosophy--without either reiterating standard interpretations or rejecting it wholesale. He develops a trans-human approach to ethics, which, by prioritizing the welfare of the earth, nature, and animals, counters the anthropocentric bias and destructive premise of modern technology. Heidegger's Ecological Turn will be of interest to Heidegger scholars and researchers working in phenomenology, hermeneutics, continental philosophy, and environmental philosophy. (shrink)

Lectures delivered as the Mary Flexner Lectures, Bryn Mawr College, fall 1965, under the title: The long perspectives.

How important is luck in economic success? No question more reliably divides conservatives from liberals. As conservatives correctly observe, people who amass great fortunes are almost always talented and hardworking. But liberals are also correct to note that countless others have those same qualities yet never earn much. In recent years, social scientists have discovered that chance plays a much larger role in important life outcomes than most people imagine. In Success and Luck, bestselling author and New York Times economics (...) columnist Robert Frank explores the surprising implications of those findings to show why the rich underestimate the importance of luck in success--and why that hurts everyone, even the wealthy. Frank describes how, in a world increasingly dominated by winner-take-all markets, chance opportunities and trivial initial advantages often translate into much larger ones--and enormous income differences--over time; how false beliefs about luck persist, despite compelling evidence against them; and how myths about personal success and luck shape individual and political choices in harmful ways. But, Frank argues, we could decrease the inequality driven by sheer luck by adopting simple, unintrusive policies that would free up trillions of dollars each year--more than enough to fix our crumbling infrastructure, expand healthcare coverage, fight global warming, and reduce poverty, all without requiring painful sacrifices from anyone. If this sounds implausible, you'll be surprised to discover that the solution requires only a few, uncontroversial steps. Compellingly readable, Success and Luck shows how a more accurate understanding of the role of chance in life could lead to better, richer, and fairer economies and societies. (shrink)

Stand-up specials seem to resemble news reporting and documentary film in that they appear prima facie to be mere documentation of an event designed to give viewers the sense of what happened at a place at a time. Closer examination, however, throws doubt upon this transparency claim and it is argued that filmic realism is not the proper lens through which to understand stand-up specials, that they represent a more artistic medium in which the director of the special needs to (...) be seen as an artist along with the comedian. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

In this work, we evaluate the status of both theory and empirical evidence in the field of experimental rest-break research based on a framework that combines mental-chronometry and psychometric-measurement theory. To this end, we provide a taxonomy of rest breaks according to which empirical studies can be classified. Then, we evaluate the theorizing in both the basic and applied fields of research and explain how popular concepts relate to each other in contemporary theoretical debates. Here, we highlight differences between all (...) these models in the light of two symbolic categories, termed the resource-based and satiation-based model, including aspects related to the dynamics and the control mechanisms at work. Based on a critical assessment of existing methodological and theoretical approaches, we finally provide a set of guidelines for both theory building and future empirical approaches to the experimental study of rest breaks. We conclude that a psychometrically advanced and theoretically focused research of rest and recovery has the potential to finally provide a sound scientific basis to eventually mitigate the adverse effects of ever increasing task demands on performance and well-being in a multitasking world at work and leisure. (shrink)

Brings Heidegger’s perspective to bear on questions of ethics, moral freedom, and its social implications, rooting much of Heidegger in his joining with or rejoinders to Kant.

Can the need for incentives justify inequality? Starting from this question, Frank Vandenbroucke examines a conception of justice in which both equality and responsibility are involved. In the first part of the inquiry, which explores the implementation of that conception of justice, the justification of incentives assumes that agents make personal choices based only upon their own interests. The second part of the book challenges the idea that a normative conception of distributive justice can be based on that traditional (...) assumption, i.e. that personal choices are not the subject matter of justice. Thus, Vandenbroucke questions the Rawlsian idea that the primary subject of a theory of justice is the basic structure of society, and not the individual conduct of its citizens. For a society to be really just, the ethos of individual conduct has to serve justice. Non-mathematical readers can skip the formal model proposed in Chapter 3 and understand the rest of the book. (shrink)

Qu'est-ce qu'un 'philosophe', au regard de l'histoire et singulièrement du XXIe siècle? Frank Pierobon, en s'appuyant sur son propre parcours et aussi sur ses dix années d'engagement dans la riche aventure des Matins-Philo à Bruxelles, tente d'apporter une réponse située à la question. Loin des imageries populaires, il fait du philosophe un homme de métier et de savoir-être dont toute l'existence oscillerait entre la création de concepts et, en même temps, une quête incessante du désir de sens. Un texte (...) court et fulgurant qui redit que nul n'est dispensé de philosopher. (shrink)

Avatar, le film de James Cameron (2009), aura ete un succes commercial d'une ampleur exceptionnelle, a considerer davantage comme le symptome d'une certaine societe en crise spirituelle, que comme l'expression personnelle d'un createur, fut-il exceptionnel. Sur cette base, Frank Pierobon, au terme d'une deconstruction tres poussee, en extrait l'embleme de notre postmodernite finissante: un Deus ex Fantasma, soit une derisoire redemption par le reve, faute de tout autre salut.

This paper articulates the commitments, contours and justifications for a pluralist but non-eclectic critical, realist, reflexive social science with emancipatory aims. In it, we stress that social science can and should be used to guide the conceptualization of desirable and viable forms of social organization and their conditions of realization. In this regard, we advocate explanatory theorizing as an ethical duty of social scientists and as a moral good in itself as well as being an inherent epistemological component of scientific (...) practice. This entails that we take seriously the research strategies apposite to our disciplinary, intertextual and interdiscursive locations to make a serious theoretical case and practical case for the kind of social science here advocated. In our view, such a social science must acknowledge the path-breaking work of Roy Bhaskar, but must also recognize that the arguments deployed in texts as a resource in intellectual work can never be treated as the axiomatic grounds for further thought, but must be interrogated thoroughly and in each case what is to be retained must be defensible. No position has a monopoly of relevant insights and the development of science often involves syntheses. Syntheses must not be syncretic but reflexively interrogated to assess epistemological, ontological and conceptual coherence to avoid eclecticism. Development in critical realist philosophy will, we believe, continue to confront and offer plausible resolutions to a range of battles within and pertinent to philosophy and social-scientific metatheory. However, realists must recognize the continuing importance and discursive effects of a variety of critical and realist work in being able to defend, sustain and develop rigorous social-scientific research with emancipatory commitments. (shrink)

This doctoral dissertation is a study of Nietzsche's views on morality in order to assess his contribution to moral philosophy. Towards this end, it examines Nietzsche's understanding of morality as well as the scope of his attack. I then offer a reading of Nietzsche's critique of morality, arguing that he rejects morality insofar as it functions within society to preserve the 'herd' at the expense of 'higher types' whose flourishing resides elsewhere. In short, I claim that Nietzsche rejects morality insofar (...) as it proves inimical to the flourishing of these 'higher types'. I also claim that Nietzsche is more than a mere critic of morality, and that his fundamental 'ethical' preoccupation with exemplary individuals is what motives his critique, and forms the basis of his affirmative ethic of human flourishing. Moreover, I contend that Nietzsche defends his positive morality by presenting the character of Zarathustra , and later himself as exemplars of human excellence who must rely on their ability to convince others performatively, rather than by means of discourse, or argumentation. Ultimately, I conclude that Nietzsche's ethics does not fit comfortably within the moral tradition as he is an opponent of deontological ethics, utilitarianism, and virtue ethics despite certain affinities with the latter. This fact does not detract from the rich contribution that Nietzsche makes to moral philosophy as bode critic and champion of an affirmative ethic. (shrink)

What is honor? Is it the same as reputation? Or is it rather a sentiment? Is it a character trait, like integrity? Or is it simply a concept too vague or incoherent to be fully analyzed? In the first sustained comparative analysis of this elusive notion, Frank Stewart writes that none of these ideas is correct. Drawing on information about Western ideas of honor from sources as diverse as medieval Arthurian romances, Spanish dramas of the sixteenth and seventeenth centuries, (...) and the writings of German jurists of the nineteenth and twentieth centuries, and comparing the European ideas with the ideas of a non-Western society—the Bedouin—Stewart argues that honor must be understood as a right, basically a right to respect. He shows that by understanding honor this way, we can resolve some of the paradoxes that have long troubled scholars, and can make sense of certain institutions that have not hitherto been properly understood. Offering a powerful new way to understand this complex notion, _Honor_ has important implications not only for the social sciences but also for the whole history of European sensibility. (shrink)

Two studies compared the development of beliefs about the stability and origins of physical and psychological traits in Japan and the United States in three age groups: 5–6-year-olds, 8–10-year-olds, and college students. The youngest children in both cultures were the most optimistic about negative traits changing in a positive direction over development and being maintained over the aging period. The belief that individual differences in traits are inborn increased with age, and in all age groups, this belief was related to (...) predictions of greater trait stability. In both cultures, all ages believed positive traits would be maintained over development. In addition to developmental similarities across cultures, cultural variations, consistent with the hypothesis that interdependent cultures have a more incremental view of traits, were present. Japanese participants were more optimistic than American participants about negative traits changing towards the positive and were more likely to attribute differences in trait expression to effort. © 2007 Elsevier Inc. All rights reserved. (shrink)

Educators find themselves in the midst of arising tide of urban school reform marked byevermore centrally designed and monitoredsystems of accountability. In response to thislooming high-stakes gaze of surveillance, thisessay offers an ethics of educationalleadership predicated upon taking up thechallenge of creatively and courageouslyauthoring one's ethical self. It seeks tocontribute to mapping an ethical terrain whichcan support the production of pedagogicalpractices, initiatives, and agendas asdistinctive, bold responses to theproliferation of one-dimensional,technicist-driven efforts which narrowlycalculate and assess student learning, teacherwork, school effectiveness, (...) and which offeranemic, foreclosed readings of a possiblefuture. My claim is that a consideration ofFoucault's ethics draws us closer torecognizing what such a project would mean andask of the educator as leader. (shrink)

Accordingly, this book will be of great interest and benefit to anyone working in the fields of phenomenology, hermeneutics, or Heidegger studies.