Previous studies of Zika virus (ZIKV) pathogenesis have focused primarily on virus‐driven pathology and neurotoxicity, as well as host‐related changes in cell proliferation, autophagy, immunity, and uterine function. It is now hypothesized that ZIKV pathogenesis arises instead as an (unintended) consequence of host innate immunity, specifically, as the side effect of an otherwise well‐functioning machine. The hypothesis presented here suggests a new way of thinking about the role of host immune mechanisms in disease pathogenesis, focusing on dysregulation of post‐transcriptional RNA (...) editing as a candidate driver of a broad range of observed neurodevelopmental defects and neurodegenerative clinical symptoms in both infants and adults linked with ZIKV infections. The authors collect and synthesize existing evidence of ZIKV‐mediated changes in the expression of adenosine deaminases acting on RNA (ADARs), known links between abnormal RNA editing and pathogenesis, as well as ideas for future research directions, including potential treatment strategies. (shrink)

Graphical AbstractAdenosine Deaminases Acting on RNA (ADARs) enzymes are prominent regulators of neural transcriptome diversity and play a role in the innate immune response. In article number 1800239, Piontkivska et al. outline how neurodevelopmental and neurodegenerative pathogenesis of Zika virus (ZIKV), including congenital Zika and Guillain-Barré syndromes, can be attributed to ADAR editing dysregulation triggered by ZIKV, Explaining Pathogenicity of Congenital Zika and Guillain-Barré Syndromes: Does Dysregulation of RNA Editing Play a Role? DOI: 10.1002/bies.201800239.

Hume is traditionally credited with inventing the ‘regularity theory’ of causation, according to which the causal relation between two events consists merely in the fact that events of the first kind are always followed by events of the second kind. Hume is also traditionally credited with two other, hugely influential positions: the view that the world appears to us as a world of unconnected events, and inductive scepticism: the view that the ‘problem of induction’, the problem of providing a justification (...) for inference from observed to unobserved regularities, is insoluble. Hume on Causation is the first major work dedicated to Hume’s views on causation in over fifteen years, and it argues that Hume does not subscribe to any of these three views. It places Hume’s interest in causation within the context of his theory of the mind and his theory of causal reasoning, arguing that Hume’s conception of causation derives from his conception of the nature of the inference from causes to effects. (shrink)

Uncertainty is pervasive in ecology where the difficulties of dealing with sources of uncertainty are exacerbated by variation in the system itself. Attempts at classifying uncertainty in ecology have, for the most part, focused exclusively on epistemic uncertainty. In this paper we classify uncertainty into two main categories: epistemic uncertainty (uncertainty in determinate facts) and linguistic uncertainty (uncertainty in language). We provide a classification of sources of uncertainty under the two main categories and demonstrate how each impacts on applications in (...) ecology and conservation biology. In particular, we demonstrate the importance of recognizing the effect of linguistic uncertainty, in addition to epistemic uncertainty, in ecological applications. The significance to ecology and conservation biology of developing a clear understanding of the various types of uncertainty, how they arise and how they might best be dealt with is highlighted. Finally, we discuss the various general strategies for dealing with each type of uncertainty and offer suggestions for treating compounding uncertainty from a range of sources. (shrink)

This article uses philosopher Miranda Fricker’s work on epistemic injustice to shed light on the legal concept of the fiduciary, alongside demonstrating the wider contribution Fricker’s work can make to business ethics. Fiduciary, from the Latin fīdūcia, meaning “trust,” plays a fundamental role in all financial and business organisations: it acts as a moral safeguard of the relationship between trustee and beneficiary. The article focuses on the ethics of the fiduciary, but from a unique historical perspective, referring back to the (...) original formulation of the fiduciary within a familial context to investigate presuppositions regarding agential capabilities, whilst also paying attention to the power mechanism embedded in the trustee–beneficiary relationship. Using Fricker’s theory of pre-emptive testimonial injustice, the analysis elucidates the impact of cumulative beneficiary silencing in contemporary contexts, and the article uncovers ethical issues of an epistemological kind at the core of the fiduciary—of epistemic injustice. (shrink)

Underdetermination arguments support the conclusion that no amount of empirical data can uniquely determine theory choice. The full content of a theory outreaches those elements of it (the observational elements) that can be shown to be true (or in agreement with actual observations).2 A number of strategies have been developed to minimize the threat such arguments pose to our aspirations to scientific knowledge. I want to focus on one such strategy: the invocation of additional criteria drawn from a pool of (...) cognitive or theoretical values, such as simplicity or generality, to bolster judgements about the worth of models, theories, and hypotheses. What is the status of such criteria? Larry Laudan, in Science and Values, argued that cognitive values could not be treated as self-validating, beyond justification, but are embedded in a three-way reticulational system containing theories, methods, and aims or values, which are involved in mutually supportive relationships (Laudan, 1984). My interest in this paper is not the purportedly self-validating nature of cognitive values, but their cognitive nature. Although Laudan rejects the idea that what he calls cognitive values are exempt from rational criticism and disagreement, he does seem to think that the reticulational system he identifies is independent of non-cognitive considerations. It is this cognitive/non-cognitive distinction that I wish to query in this paper. Let me begin by summarizing those of my own views about inquiry in which this worry about the distinction arises. (shrink)

This article examines a changing global reality that manifests itself in new forms of social activism. The struggle of the multitude challenges political representation and contemporary art seems to corroborate this observation. Becoming a form of social intervention, it turns into an active force and leaves behind the need to double action with representation, representational practices being the hallmark of classical art. A new theory of the image would have to incorporate this dynamic: it would have to treat and develop (...) the basic categories of action and relation. There are few philosophies of the act, and the existing semiotic models mostly deal with dual structures (signifier/signified; sign/meaning; image/referent, and so on). It is necessary to sketch out a dynamic theory of the image that would: (1) reveal the limitations of the concept of representation; (2) conceive of the image as a set of multiple changing relations. The image would thus be seen as a necessary part of the relations governing the world in its entirety, that is, as part of the movement of matter itself. Which is another way of saying that those relations are actualized, or expressed, in the image. (shrink)

First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

This paper argues for the replacement of the Principle of Alternate Possibilities by an alternative principle, the Principle of Possible Non-Performance, which it is argued represents an important improvement on the Principle of Alternate Possibilities in the context of Frankfurt-style examples. The suggestion that the principle offers only the possibility of something insufficiently 'robust' to supply a decent replacement to PAP is countered.

Feminist scholars advocate the adoption of distinctive values in research. While this constitutes a coherent alternative to the more frequently cited cognitive or scientific values, they cannot be taken to supplant those more orthodox values. Instead, each set might better be understood as a local epistemology guiding research answerable to different cognitive goals. Feminist scholars advocate the adoption of distinctive values in research. While this constitutes a coherent alternative to the more frequently cited cognitive or scientific values, they cannot be (...) taken to supplant those more orthodox values. Instead, each set might better be understood as a local epistemology guiding research answerable to different cognitive goals. (shrink)

According to Jonathan Quong’s _moral status account_ of liability to defensive harm, an agent is liable to defensive harm only when she mistakenly treats others as if their moral status is diminished (for example, as if they lack a right that they in fact possess). Quong argues that, by the lights of the moral status account, a conscientious driver (Driver) who faultlessly threatens to kill Pedestrian is not liable to defensive harm. Quong argues that Driver’s action is evidence-relative permissible, despite (...) the risks it imposes, because the general practice of prudent driving is permissible. The practice is permissible because (a) its risks do not disproportionately fall on some groups rather than others, (b) the threatened harms are incidental, and (c) the risk that driving imposes is acceptable in light of the benefits everyone derives from driving. Because the correct moral theory tells us that prudent driving is permissible, Pedestrian lacks a right that Driver refrain from driving. Hence, Driver does not, by driving, treat Pedestrian as lacking a right that Pedestrian in fact possesses. Driver is not liable to defensive force. I argue, against Quong, that cost–benefit analyses of types of risky activity cannot justify individual tokens of risk imposition. Actions that risk incidentally harming others must be justified by the prospective benefits of that token action. Hence, Driver’s imposition of risk on Pedestrian cannot be justified by the benefits of the general practice of driving. I argue that the permissibility of Driver’s imposing risk on Pedestrian via prudent driving turns on whether Driver is willing to internalise at least the foreseeable costs of that risky action. One can lack a right that a person refrain from performing a risky action whilst possessing a right not to be harmed by that risky action. Even if Pedestrian cannot reasonably demand that Driver refrain from driving, she can reasonably demand that Driver refrain from forcing her to bear the costs of his driving. (shrink)

Care appears prima facie antithetical to punishment. Since the overlaps between care and punishment are greater than we paradigmatically expect, care ethics offers a more accurate account of prisons: recognising and critiquing both dehumanising carceral violence, and the necessity, presence, and inadequacies of penal care, as well as unlocking ways of thinking differently about structural change without losing sight of individual issues. After introducing care ethics and evidencing the presence of caring practices in present prisons, the article considers how we (...) punish, in terms of the amount, method, and manner. Treating people in punishment as moral equals is important for liberal deontological penal theories. Treatment as equals requires context. Context is intrinsic to care‐ethics praxis, which provides methods of and standards for accessing and applying this information. (shrink)

There is a form of argument for a certain kind of essentialist conclusion which appears not to depend upon any appeal to intuition. Identity statements involving natural kind terms are often adverted to in the literature as examples of the necessary a posteriori, and it can appear as though the essentialist is on very strong ground with respect to these claims. It is not merely that they are apt to strike one as plausible in the light of philosophical arguments or (...) modal intuitions; rather, they appear to be provable, given only fairly trivial logical principles and uncontroversial scientific truths. This paper attempts to counter the claim, made particularly convincing by the work of Saul Kripke, that this indeed the case. (shrink)

In this paper I examine the temporal dimensions of racialised and colonised embodiment. I draw on the work of Alia Al-Saji, whose phenomenological reading of Frantz Fanon examines the multiple ways in which racism and colonialism affix the racialised and colonised body to that of the past; a temporalisation that serves not only to anachronise these bodies, but also to close off their projective possibilities for being or becoming otherwise. Such a move reflects the nature of racialisation itself, which following (...) Charles Mills, does not just exteriorise or ‘other’ racialised bodies, but relies equally on a forgetting, or a disavowal and leaving behind of this very process. The result, I argue, is to render whiteness and white bodies as temporally present and even futural in their orientation, free from the vestiges of racism's history and free to adopt any number of stances on its continuing legacy. It is against this that I argue that the familiar exhortation to ‘get over’ racism whenever the charge is levelled, is not only dangerous in its denial of racism, but also disingenuous in purporting to move beyond a racially divided world, when in fact this very gesture serves to reinscribe differential racialised temporalities. (shrink)

An agent A morally coerces another agent, B, when A manipulates non-epistemological facts in order that B’s moral commitments enjoin B to do what A wants B to do, and B is motivated by these commitments. It is widely argued that forced choices arising from moral coercion are morally distinct from forced choices arising from moral duress or happenstance. On these accounts, the fact of being coerced bears on what an agent may do, the voluntariness of her actions, and/or her (...) accountability for any harms that result from her actions. This paper does not provide an account of the wrongness of moral coercion. Rather, I argue that, whatever the correct account of its wrongness, the mere fact of being coerced has no bearing on what the agent may do, on the voluntariness of her action, or her accountability for any resultant harm, compared to otherwise identical cases arising from duress and happenstance. (shrink)

In her ‘Causality and Determination’, Anscombe argues for the strong thesis that despite centuries of philosophical assumption to the contrary, the supposition that causality and necessity have something essential to do with one another is baseless. In this paper, I assess Anscombe’s arguments and endorse her conclusion. I then attempt to argue that her arguments remain highly relevant today, despite the fact that most popular general views of causation today are firmly probabilistic in orientation and thus show no trace of (...) the assumptions Anscombe hoped to undermine. My suggestion is that Anscombe's interests in causality are distinct from those which mostly animate the modern debate about the general nature of causality and that in those specialized areas of philosophy in which those concerns still dominate, one can still see the effects of the fallacies and confusions to which she alerts us. I conclude by offering two possible complementary explanations of the tendency to suppose that causation is a variety of necessitation. (shrink)

The modern view of causation can be traced back to the mechanistic science of Descartes, whose rejection of Aristotelian physics, with its concept of substantial forms, in favor of mechanical explanations was a turning-point in the history of philosophy. However the reasoning which led Descartes and other early moderns in this direction is not well understood. This book traces Descartes' groundbreaking theory of scientific explanation back to the mathematical demonstrations of Aristotelian mechanics and interprets these advances in light of the (...) available arguments for and against substantial forms. It also examines how Descartes' new theory led him to develop a metaphysical foundation for his science that could avoid skeptical objections. It will appeal to a wide range of readers interested in the philosophy and science of the early modern period. (shrink)

Despite tributes paid to Fuller as an intellectual father of ADR, little attention has been paid within the ADR field to the broader interactionist vision that underlies Fuller’s discussion about process. A closer reading of Fuller’s study of mediation, however, reveals that he intended that study to substantiate his interactionist thesis about the nature of social ordering. He understood ordering to be generated by and to reflect a particular experience of social interaction. Fuller’s interactionist vision recognizes the creative, choice-making and (...) purposive dimensions of human reality, emphasizes participation as a normative criterion for institutional design, and gives rise to a pluralistic notion of power arrangements. It appears in Fuller’s thinking about process as a kind of dialectic and integrative mindset that pervades his means-ends analysis, functional analytical approach and his emphasis on institutional design. This interactionist vision has particular relevance for the practice and research of ADR, for example, in helping to develop a more integrative approach to process pluralism. (shrink)

In terms of physics, mass is the fixed attribute of an object while weight varies with the accelerative force. Neither weight nor mass are simple sensory stimuli as both involve the integration of sensory and motor information with higher cognitive processes. Studies of apparent heaviness yield only vague information about sensorimotor mechanisms.

This 1999 book demonstrates a method for reading the texts of Aristotle by revealing a continuous line of argument running from the Physics to De Caelo. The author analyses a group of arguments that are almost always treated in isolation from one another, and reveals their elegance and coherence. She concludes by asking why these arguments remain interesting even though we now believe they are absolutely wrong and have been replaced by better ones. The book establishes the case that we (...) must rethink our approach to Aristotle's physical science and Aristotelian texts, and as such will provoke debate and stimulate new thinking amongst philosophers, classicists, and historians of science. (shrink)

Preference utilitarians are concerned to maximize the autonomous choices of individuals; for this reason, they argue that nurses ought to advocate for those patients who desire assistance with ending their lives. This approach prompts us to consider, then, the moral validity of nursing involvement in measures intended to end the lives of patients. In this article, the terms of preference utilitarianism are set out and considered in order to determine whether this approach offers sufficient philosophical support for sanctioning a role (...) for nursing in euthanasia. Ultimately, it is found that preference utilitarianism is lacking in this respect, as well as in its fitness for guiding nursing activity in general. In particular, it is found that nurses are required to exchange a handmaiden relationship with the medical profession for an equally undignified relationship with patients. If nursing involvement in measures intended to end the lives of patients is to find sufficient philosophical support, then we need to look elsewhere. (shrink)

In this article, I discuss the structural domination of whiteness as it intersects with the potential of individual critique and reflexivity. I reflect on my positioning as a white nurse researcher while researching international nurse migration. I draw on two large qualitative studies and one small focus group study to discuss my reactions as a white researcher to evidence of institutional racism in the British health services and my growing awareness of how racism is reproduced in the British nursing profession.

: In this paper I address the vexed question of secondary causation in René Descartes' physics, and examine several influential interpretations, especially the one recently proposed by Dennis Des Chene. I argue that interpreters who regard Cartesian bodies as real secondary causes, on the grounds that the modes of body include real forces, contradict Descartes' account of modes. On the other hand, those who deny that Descartes affirms secondary causation, on the grounds that forces cannot be modes of extension, commit (...) Descartes to the problematic view that the undetermined and immutable will of God is the sole cause of determinate and variable motions. Des Chene's contextualist approach to Descartes' texts leads him to an intermediate position that combines elements of both interpretations. However, in my view, Des Chene's interpretation likewise fails to resolve apparent tensions in Descartes' claims. I thus propose to separate the issue of secondary causation from what Des Chene dubs 'the problem of force'. On the basis of this approach, and a study of Jesuit commentaries familiar to Descartes, I develop a new interpretation which takes seriously Descartes' claim that the laws of nature are the secondary and particular causes of particular motions and changes in motion. (shrink)

With reference to the work of Gabriel Marcel (1889–1973), this paper illustrates how, in spite of its general neglect in philosophical contexts, narrativeform can be significant in philosophical writing. This, in turn, highlights an aspect of Marcel’s specificity that has been overlooked: recognition of narrative’s structural importance in Marcel reveals the extent to which the form and content of his investigations into the nature of Being are indissociable; and this sheds light on his particular phenomenological method, which, like that of (...) Martin Heidegger (1889–1976), takes an indirect approach to ontology—specifically through itsuse of first-person narratives. For this reason, I argue, parallels can also be drawn between Marcel’s philosophy and that of Paul Ricoeur (1913–2005)—especiallywith his discussions of narrative identity. (shrink)

Historians of science have a lingering Europe (and U.S.) problem, even as the field has undergone its own transnational, imperial, and global turns that have broadened its scope. Likewise, area studies scholars have a lingering science problem, in spite of the growing chorus of voices insisting that non-European peoples’ knowledge and innovations warrant a place in global histories about science, technology, and medicine. This essay examines these two fault lines using the biochemist-turned-historian Joseph Needham as a point of departure. Needham’s (...) studies of science in China not only decentered Europe but also raised central questions about how science and its companions, reality and reason, would be defined. The essay takes a closer look at debates arising from these fault lines and urges scholars to experiment with polycentric histories of science that are coterminous and intersecting. It also underscores the need for new syntheses of research on the ways intellectuals, bricoleurs, and polities the world over have generated and transformed ideas and tools, and set them in motion. (shrink)

In an earlier article, it was found that the terms of preference utilitarianism are insufficiently sound for guiding nursing activity in general, including in relation to nursing involvement in euthanasia. In this article, I shall examine the terms of a more traditional philosophical approach in order to determine the moral legitimacy, or otherwise, of nursing engagement in measures intended to end the lives of patients. In attempting this task, nursing practice is considered in light of what I shall call a (...) ‘nursing‐as‐healing‐praxis’ approach which includes an account of the moral purpose of nursing and the virtues necessary for realizing that purpose. Ultimately, it is concluded that the terms of this approach rule out the involvement of nurses in euthanasia such that if euthanasia can be justified at all, those outside the nursing profession must provide for its administration. (shrink)

This is a review of William Hasker's 'The Emergent Self' (Ithaca: Cornell University Press, 2001).

Poetics of futurism: Zaum, shiftology, nonsense -- Poetics of Deleuze: structure, stoicism, univocity -- The materialist manifesto -- Shiftology #1: from performativity to dramatisation -- Shiftology #2: from metaphor to metamorphosis -- The see-sawing frontier: linguistic spatiotemporalities -- Concllusion: Suffixing, prefixing.

The field of educational leadership is multi-site, in which those who study and practice leadership are located within networks which connect across institutions and sectors. Charting the growth of this dynamic field is the central purpose of this paper and six interconnected typologies of knowledge production are presented: Producers, Positions, Provinces, Practices, Processes and Perspectives. We argue that these typologies enable those involved to generate descriptions and understandings of the interplay between researching, theorising and practising in educational settings. This focus (...) on knowledge production enables us to be mappers, to undertake mapping and to produce maps. These, we would stress, are all political processes through which we challenge what is said to be known and make our own claims to know. As such our agency to make choices within our practice as researchers, theorists, and practitioners is exercised within a complex setting of organisational, cultural and social structures. (shrink)