Background: Freezing of gait is a common symptom in Parkinson’s disease and can be difficult to treat with dopaminergic medications or with deep brain stimulation. Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation delivers current in various frequencies of bursts, while maintaining an intra-burst frequency identical to conventional DBS.Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG.Methods: Ten PD subjects with STN or GPi DBS (...) and complaints of FOG were recruited for this single center, single blinded within-subject crossover study. For each subject, we compared 4, 10, and 15 Hz BCDBS to conventional DBS during the PD medication-OFF state.Results: There were no serious adverse events with BCDBS. It was feasible and straightforward to program BCDBS in the clinic setting. The benefit was comparable to conventional DBS in measures of FOG, functional mobility and in PD motor symptoms. BCDBS had lower battery consumption when compared to conventional DBS.Conclusions: BCDBS was feasible, safe and well tolerated and it has potential to be a viable future DBS programming strategy. (shrink)

DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)

Using Brehm's (1999) intensity of emotion paradigm, we investigated whether basic positive or negative affect operates like a motivational state. We focused on one of the most basic affects, the sensory affect experienced when eating food. Participants tasted a delicious chocolate truffle (Study 1) or some bitter chocolate (Study 2) and were exposed to either a weak, moderately strong, or a very strong reason for feeling an opposing-valence affect or to no reason. In line with the predictions, the affect that (...) participants reported in response to chocolate functioned like a motivational state as its intensity was a cubic function of the importance of the reason for feeling an opposing affect. We discussed the implications of these findings for the conceptualisation of affect and consider several applications for food advertising and consumer rating research. (shrink)

Psychologism in logic holds that logic is a branch of psychology. This view has been vigorously defended by John Stuart Mill and by a number of German philosophers of logic, notably Erdmann. Its chief critics have been Husserl and Frege and, to a lesser extent, Russell. Husserl set forth a profound and detailed critique of psychologism in Logical Investigations. This paper examines this critique. First, I explain why the psychologistic theory is attractive. Then I show that Husserl's critique is not (...) convincing, partly because he does not take the theory in its most plausible form and partly because he ignores certain important distinctions (for example, between what a statement is about and what it is true in virtue of). Then I raise two new objections to the psychologistic theory. The purpose of this paper is to suggest that the psychologistic theory remains an important and serious position from which we can learn much about the status of logic. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Jack W. Meiland INTERPRETATION AS A COGNITIVE DISCIPLINE Interpretation is the fundamental method of the humanities. The humanist is concerned first to understand what a text, a speech, a work of art, means; and interpretation has this understanding as its goal. All of the other activities and aims of the humanist depend on interpretation. One cannot properly appreciate a work of art until one grasps what it means. (...) Nor can one appropriately evaluate it until this condition is met. Moreover, the importance of interpretation reaches far beyond the humanities into everyday life, where we interpret what we hear and read in order to grasp meanings. Its importance reaches into the sciences: the social sciences where one must interpret this individual behavior and that institutional practice, and the natural sciences where one must interpret the results of one's experiments. Because interpretation is of such fundamental and pervasive importance in our lives, it is urgent for us to understand what interpretation is and what it should aim at. In this article, I investigate the activity of interpretation by focusing on the interpretation of literary texts and by beginning with the views of E. D. Hirsch, Jr. Eleven years ago, Hirsch published Validity in Interpretation, a book which delves into the nature of interpretation in great detail.1 Richard Palmer has said that Hirsch's book is "the first full-dress treatise in general hermeneutics written in English," and continues, "In the years to come, it will undoubtedly take its place among the significant American works on the theory of interpretation. In a systematic and carefully argued presentation, the book challenges some of the most cherished assumptions that have guided literary interpretation for some four decades."2 1 think that Palmer's prediction has been fulfilled. Hirsch's book remains a decade later one of the very few systematic American works in this field,3 and it has been widely read, much used in university courses, and has significantly influenced thought on its subject. Validity in Interpretation presents a carefully worked-out position buttressed by philosophically-informed 23 24Philosophy and Literature and systematic argumentation in a way which reveals the fundamental questions at issue. Although there have been scattered criticisms of Hirsch's views,4 in my opinion there has not so far appeared the kind of searching critique which this book deserves in view of its attempt to deal with these issues so seriously and at such a fundamental level and in view of the influence which the book has had. The necessity for a critique is now reinforced by the recent publication of another book by Hirsch, The Aims of Interpretation, more than half of which is devoted to a further explication and defense of these same views.5 In undertaking to reply to Hirsch's position, I hope not only to cast doubt on that position but also, and mainly, to provide better foundations for the view which I hold. It is one of the great merits of Hirsch's work that it facilitates that constructive effort by attacking the issues at such a basic level, enabling us to come to grips with them immediately. In what follows, I will describe Hirsch's view, make clear what kind of position he holds, and defend his view against criticisms which I consider misguided. Then we will be in a position to assess his contentions and to defend an alternative theory. Hirsch's view is, briefly, that the interpretation of a literary work should aim at re-creating (or, as he sometimes puts it, "re-cognizing") the meaning which the author of that work intended the work to have. He opposes all views which ignore authorial meaning; views which hold that the meaning of a work may change through the ages, so that the work may have one meaning at one time and another meaning at another time; views which hold that the work may have meaning in virtue of its relation to the interpreter's interests, to the needs and problems of the interpreter's times or the spirit of his age, or in fact to anything except the author's intended meaning.6 The first point that must be... (shrink)

It is sometimes said that our age is an age of relativism. For example, Paul Tillich has expressed his “uneasiness about the victory of relativism in all realms of thought and life today.” Karl Popper tells us that “the main philosophical malady of our time is an intellectual and moral relativism, the latter being at least in part based on the former.” What Popper refers to as “intellectual relativism” consists in part in a doctrine about truth which is sometimes expressed (...) as “There is no such thing as absolute truth.” At other times it is expressed by saying “truth is relative.”. (shrink)

Moffett contends that societies should be considered the “primary” group with respect to their social ramifications. Although intriguing, this claim suffers from insufficient clarity and evidence. Rather, if any group is to be crowned supreme it should surely be the family, with its unique capacity to encourage pro-group behavior, shape other groups, and provide meaning.

This article challenges the current scholarly consensus that Suetonius wrote the Divus Iulius regardless of Plutarch. Closer examination of the Caesar-biographies shows which influence Plutarch has exerted by his biographic works on Suetonius and reveals that the dominant position in the classical studies is obsolete. This paper scrutinises not only clearly defined knowledge of the Quellenforschung, but illuminates also the role model of Plutarch. Before it is possible to assess the dependence of the Divus Iulius from the Καισαρ, I will (...) reopen the case of the composition dates, examine the literary circles as a space of interaction and look on Plutarch’s reception in Rome. (shrink)

This paper first explains why the charge of self-refutation against extreme relativism is so important and then defends extreme relativism against two of the most recent and most sophisticated accusations of self-refutation. It is shown that these accusations seem plausible only because they illicitly employ principles appropriate only to absolute truth; hence these accusations are unsound. One central topic of discussion in the paper is the relation between "a believes that p" and "p is true for a".

This paper first explains why the charge of self-refutation against extreme relativism is so important and then defends extreme relativism against two of the most recent and most sophisticated accusations of self-refutation. It is shown that these accusations seem plausible only because they illicitly employ principles appropriate only to absolute truth; hence these accusations are unsound. One central topic of discussion in the paper is the relation between "a believes that p" and "p is true for a".

In his valuable book [3], Israel Scheffler presents an extended critique of Thomas Kuhn's philosophy of science. Scheffler argues against Kuhn's “main thesis,” namely that “... paradigm change in science is not generally subject to deliberation and critical assessment”. Scheffler does recognize, though, that there are important elements of Kuhn's view that themselves seem to conflict with this “main thesis.” For these elements seem to make possible deliberation, critical assessment, and objectivity in the discussion of scientific paradigms. So it appears (...) from Scheffler's critique that Kuhn's position is inconsistent. The puzzle is compounded by Kuhn's admission—indeed, insistence—that his book does contain “a preliminary codification of good reasons for theory choice. These are... reasons of exactly the kind standard in philosophy of science: accuracy, scope, simplicity, fruitfulness, and the like”. In his recent reply to Kuhn, Scheffler quotes this passage from Kuhn and says: “If these reasons are not... to be construed as utterly free of all constraints or themselves paradigm-dependent, then they allow the comparison of rival paradigms and make paradigm debates intelligible. Such intelligibility is, however, at odds with Kuhn's statement that the proponents of competing paradigms ‘will inevitably talk through each other’”. In this interchange between Scheffler and Kuhn, one gets the impression of people, if not paradigms, talking “through each other.” I think that this nonmeeting of minds is due to interpreting Kuhn as an opponent of objectivity when in fact he is not an opponent but a proponent. It is this misinterpretation which produces the apparent inconsistency in Kuhn's position. In this paper I suggest a way of understanding Kuhn which resolves this apparent inconsistency in his work and might help to focus discussion on the real issue between Kuhn and many of his critics. This suggestion has the crucial consequence of shifting the focus from objectivity to the real issue, namely truth. (shrink)

Despite seemingly ambiguous writings, Beard is a relativist. Beard states that if historical conceptions are relative, then relativity is relative; this is not a rejection of relativism. As times change, doctrines become outmoded. Beard's times were right for relativism, so he was a relativist, despite his knowledge of its eventual demise. Relativism cannot provide the historian with a frame of reference to interpret the "totality of history." He must choose a comprehensive and informed frame. Beard seems to indicate that historians (...) can forecast the future; yet, this contradicts his rejection of absolute historical truths. He is not discussing forecasting future events, but forecasting future frames of reference. (shrink)

Despite legislation and public education, racism and sexism are alive and well. Though pre‐conceptive gender selection may enhance procreative liberty, this technology presents two disturbing questions. First, does sex selection represent underlying parental sexism? Second, by performing gender selection, do medical professionals perpetuate sexism? It will be maintained that pre‐conceptive sex selection is sexist as it reflects parental anticipation of stereotypical gender based behavior. Perhaps even more incriminating, sex selection forces parents to prefer one sex over another, to place a (...) value on gender. This emphasis on sex conflicts with societal goals which urge, and often legally require, individuals to ignore gender. We will assert that pre‐conceptive gender selection exemplifies sexism in its purest most blatant form as prior to conception, before parents can possibly know anything about their child, gender dominates the calculus of a child’s worth. We will also emphasize that physicians, by facilitating sex selection, legitimize the motivations of their patients and provide de facto support of sexism. In a similar vein, arguments against pre‐conceptive race selection will be made. (shrink)

According to Brehm's intensity of emotion theory, if an emotion has motivational properties, its intensity should be non-monotonically affected by factors similar to those determining the intensity of motivational states. These factors are called deterrents. In the case of emotion, one category of deterrents consists of factors that can potentially interfere with feeling the emotion, such as reasons for not feeling the emotion. Two experiments were carried out to examine whether happiness is a motivational state and, thus, if its intensity (...) is non-monotonically determined by the importance of reasons for not feeling happy. We expected happiness to be reduced by a low importance reason for not feeling happy, to remain high in the presence of a moderately important reason, and to be reduced or eliminated by a very important reason. Both experiments supported the cubic function that results from these expectations, and when the results of the two studies were combined, each of the individual legs of the cubic function was found to be reliable along with the cubic function itself. The theoretical implications of these results are discussed. (shrink)

Red-2 is a computer program for red-cell antibody identification, a piece of "normal science". Abstracting from Red-2, a general problem solving mechanism is described that is especially suited for performing a form of abductive inference or best explanation finding. A problem solver embodying this mechanism synthesizes composite hypotheses by combining hypothesis parts. This is a common task of intelligence, and a component of scientific reasoning. The work addresses the question, 'How is science possible?' by showing how a simple but powerful (...) form of hypothesis synthesis is computationally feasible. (shrink)

Bioregionalists have championed the utility of the concept of the watershed as an organizing framework for thought and action directed to understanding and implementing appropriate and respectful human interaction with particular pieces of land. In a creative analogue to the watershed, permaculturist Arthur Getz has recently introduced the term “foodshed” to facilitate critical thought about where our food is coming from and how it is getting to us. We find the “foodshed” to be a particularly rich and evocative metaphor; but (...) it is much more than metaphor. Like its analogue the watershed, the foodshed can serve us as a conceptual and methodological unit of analysis that provides a frame for action as well as thought. Food comes to most of us now through a global food system that is destructive of both natural and social communities. In this article we explore a variety of routes for the conceptual and practical elaboration of the foodshed. While corporations that are the principal beneficiaries of a global food system now dominate the production, processing, distribution, and consumption of food, alternatives are emerging that together could form the basis for foodshed development. Just as many farmers are recognizing the social and environmental advantages to sustainable agriculture, so are many consumers coming to appreciate the benefits of fresh and sustainably produced food. Such producers and consumers are being linked through such innovative arrangements as community supported agriculture and farmers markets. Alternative producers, alternative consumers, and alternative small entrepreneurs are rediscovering community and finding common ground in municipal and community food councils. Recognition of one's residence within a foodshed can confer a sense of connection and responsibility to a particular locality. The foodshed can provide a place for us to ground ourselves in the biological and social realities of living on the land and from the land in a place that we can call home, a place to which we are or can become native. (shrink)

This paper deals with four ethical issues in the development and application of business and management knowledge. The issues examined are: (1) failure to adopt or disclose knowledge with proven value that could benefit individuals, organizations, and society; (2) inappropriate implementation or incomplete disclosure of knowledge with proven potential; (3) use of knowledge for the exclusive benefit of a selected interest group even if harm is done to others; and (4) intentional falsification or misrepresentation of knowledge as something other than (...) what it is known to be. Each of these issues are illustrated with actual case histories and are examined using frequently accepted ethical concepts. (shrink)

"The premise of this collection is that despite this perceptual sharing, "sublime economy" has yet to be investigated in a purely cross-disciplinary way.