In 2013, Kurt Ullrich set out to chronicle the magic of the Iowa State Fair in words and photographs. Join him as August days and nights blow warm and easy over the fairgrounds, brushing lightly against fellow travelers on this earth, both human and not. He captures precious moments of extreme joy and unbridled delight in these beautiful black-and-white images, celebrating the brash rural energy of the fair, from Big Wheel races to people-watching goats, fair queen contestants to (...) arm wrestlers, Percherons to ponies. Prize pigs, prize sheep, prize apples, and the famous butter cow all have their moment in the limelight. Iowa s very best ear of corn and old friends reminiscing outside their RVs draw the photographer s fond eye, as do brightly lit beer stands and the brilliant arc of the Ferris wheel against the night sky. ". (shrink)

From dogs to gods, the science of understanding mysterious minds--including your own. Nothing seems more real than the minds of other people. When you consider what your boss is thinking or whether your spouse is happy, you are admitting them into the "mind club." It's easy to assume other humans can think and feel, but what about a cow, a computer, a corporation? What kinds of mind do they have? Daniel M. Wegner and Kurt Gray are award-winning psychologists who (...) have discovered that minds--while incredibly important--are a matter of perception. Their research opens a trove of new findings, with insights into human behavior that are fascinating, frightening and funny. The Mind Club explains why we love some animals and eat others, why people debate the existence of God so intensely, how good people can be so cruel, and why robots make such poor lovers. By investigating the mind perception of extraordinary targets--animals, machines, comatose people, god--Wegner and Gray explain what it means to have a mind, and why it matters so much. Fusing cutting-edge research and personal anecdotes, The Mind Club explores the moral dimensions of mind perception with wit and compassion, revealing the surprisingly simple basis for what compels us to love and hate, to harm and to protect. (shrink)

BackgroundEverybody has the right to decide whether to receive specific medical treatment or not and to provide their free, prior and informed consent to do so. As dementia progresses, people with Alzheimer’s dementia (PwAD) can lose their capacity to provide informed consent to complex medical treatment. When the capacity to consent is lost, the autonomy of the affected person can only be guaranteed when an interpretable and valid advance directive exists. Advance directives are not yet common in Germany, and their (...) validity is often questionable. Once the dementia diagnosis has been made, it is assumed to be too late to write an advance directive. One approach used to support the completion of advance directives is ‘Respecting Choices’®—an internationally recognised, evidence-based model of Advance Care Planning (ACP), which, until now, has not been evaluated for the target group of PwAD. This study’s aims include (a) to investigate the proportion of valid advance directives in a memory clinic population of persons with suspected AD, (b) to determine the predictors of valid advance directives, and (c) to examine whether the offer of ACP can increase the proportion of valid advance directives in PwAD.MethodWe intend to recruit at leastN = 250 participants from two memory clinics in 50 consecutive weeks. Of these, the first 25 weeks constitute the baseline phase (no offer of ACP), the following 25 weeks constitute the intervention phase (offer of ACP). The existence and validity of an advance directive will be assessed twice (before and after the memory clinic appointment). Moreover, potential predictors of valid advance directives are assessed.DiscussionThe results of this study will enhance the development of consent procedures for advance directives of PwAD based on the ACP/Respecting Choices (R) approach. Therefore, this project contributes towards increasing the autonomy and inclusion of PwAD and the widespread acceptance of valid advance directives in PwAD.Trial RegistrationDRKS, DRKS00026691, registered 15th of October 2021,https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00026691. (shrink)

This paper, originating from a Wittgenstein conference in Delphi, Greece in June 2001, questions Brandom’s reading of Wittgenstein on “Following a Rule”. For the purpose of our current investigative dispute, it is a very good starting point to draw our attention to some of the vital differences between Wittgenstein’s and Brandom’s approach to the relation between practice and rules that may not be quite as clear at first sight from Brandom’s own writings. This writing maintains that Brandom misconstrues Wittgenstein’s remarks (...) about signposts and Philosophical Investigations §201 with the consequence that his own explications about tacit rules involved in practice seem more Wittgensteinian than they really are. For one, Brandom duplicates Wittgenstein’s requirement of correctness in rule following: “...correctness that consists in following a rule [does not presuppose] correctness that does not.” On the other hand Brandom’s reading makes Wittgenstein’s quietism look like ”a pretext for not doing constructive work”, while Wittgenstein’s point is that there is nothing left to enquire. (shrink)

The Routledge Handbook of Practical Reasonis an outstanding reference source to this exciting and distinctive subject area. Comprising over thirty chapters by a team of international contributors the handbook provides a comprehensive overview of the field covering questions such as: What is the nature of the reasons for which we act and what is the nature of the faculty of practical reason? What are normative reasons for action? What is practical irrationality and what are the requirements, permissions, and powers that (...) explain what it is to be practically rational and irrational? What is the relationship between ethics and the philosophy of practical reason? This handbook will be essential reading for philosophy students and researchers in metaethics, philosophy of action, action theory, ethics and history of philosophy. (shrink)

Our recent review demonstrates that “purity” is a messy construct with at least nine popular scientific understandings. Cultural beliefs about self-control help unify some of these understandings, but much messiness remains. The harm-centric theory of dyadic morality suggests that purity violations can be comprehensively understood as abstract harms, acts perceived by some people (and not others) to indirectly cause suffering.

The question of the moral status of human nature is today being posed above all under the influence of medical and biotechnological aspects. These facilitate not only an increasing number of, but also increasingly far-reaching interventions and manipulations in humans, so that the perspective of a gradual "technologization" of his physical constitution can no longer be regarded as merely utopian. Some authors are convinced that this disturbing development can only be halted when an inherent value is (once again) ascribed to (...) human nature. After a short description of this situation (I), the following paper first examines the difficulties that arise as regards an adequately precise descriptive definition of human nature (II) and, in a second step, the problems posed by the necessity to define the normative status of human nature (III). It hereby comes to the conclusion that a precise definition of "human nature" is not possible for fundamental reasons, and that only a weak normativity can be warranted. (shrink)

In its first part, this paper seeks to make plausible (a) that molecular genetic diagnostics differs in ethically relevant ways from traditional types of medical diagnostics and (b) that the consequences of introducing this technology in broad screening-programs to detect widespread genetic diseases in a population which is not at high risk may change our understanding of health and disease in a problematic way. In its second part, the paper discusses some aspects of public control of scientific and technological innovations (...) in the field of molecular genetic diagnostics. (shrink)

IntroductionLittle is known about risk factors for both Long COVID and somatic symptoms that develop in individuals without a history of COVID-19 in response to the pandemic. There is reason to assume an interplay between pathophysiological mechanisms and psychosocial factors in the etiology of symptom persistence.ObjectiveTherefore, this study investigates specific risk factors for somatic symptom deterioration in a cohort of German adults with and without prior SARS-CoV-2 infection.MethodsGerman healthcare professionals underwent SARS-CoV-2 IgG antibody testing and completed self-rating questionnaires at baseline (...) and 21 months later between April 2020 and February 2022. Differences in variables between the time points were analyzed and a regression analysis was performed to predict somatic symptom deterioration at follow-up.ResultsSeven hundred fifty-one adults completed both assessments. Until follow-up, n = 58 had contracted SARS-CoV-2 confirmed by serology. Between baseline and follow-up, signs of mental and physical strain increased significantly in the sample. Symptom expectations associated with COVID-19 and a self-reported history of COVID-19, but not serologically confirmed SARS-CoV-2 infection, significantly predicted somatic symptom deterioration at follow-up. A further predictor was baseline psychological symptom burden.ConclusionsThis study supports a disease-overarching biopsychosocial model for the development of burdensome somatic symptoms during the COVID-19 pandemic and supports research findings that symptom burden may be more related to the psychosocial effects of the pandemic than to infection itself. Future studies on Long COVID should include SARS-CoV-2 negative control groups and consider symptom burden prior to infection in order to avoid an overestimation of prevalence rates. (shrink)

1. It seems that the description and explanation of what is going on in inanimate nature differ in important respects from the description and explanation of what is going on when that involves human beings or certain animals. The difference is sometimes expressed by saying that whereas in the former case what we describe and explain is always events, in the latter it is sometimes events and sometimes actions. Material objects, one might say, do not do anything, do not perform (...) actions, are not agents. The question arises whether the differences between material objects and agents, and consequently between events and actions, are such as to render inapplicable to actions the categories of explanation employed in the natural sciences. This question is sometimes answered in the affirmative. In particular, it is argued that actions do not admit of causal explanations, or of explanations in terms of necessary and sufficient conditions, or in terms which imply that the occurrence of an action is wholly determined. Or it is argued more cautiously, that, even if some kinds of action are so explicable, the most important kinds, those which are voluntary, intentional, deliberate, cannot be. In this essay, I argue for a third theory. It shares with the first two the view that in the narration and description of events and actions we do not employ exactly the same categories and that, therefore, in the explanation of one, reference may have to be made to types of fact not mentioned in the explanation of the other. Thus, in the explanation of why I raised my arm, I may have to refer to my purpose, intention or aim, whereas in the explanation of my arm’s going up, this may be irrelevant. Nevertheless, the theory here defended maintains that all kinds of action, including intentional ones, admit of causal or deterministic explanations. (shrink)

Gauthier's magnificent book erects a conception of morality, “morals by agreement,” on the foundation of his own theory of practical rationality. This is as it should be if, as he claims, following Hobbes and others, there is an initial “presumption against morality” and no theory of morals “can ever serve any useful purpose, unless it can show that all the duties it recommends are also truly endorsed in each individual's reason”, indeed, that it is a requirement of rationality that one (...) always satisfy the requirements of morality. This means, however, that the initial assumption against morality is inherited by his theory of practical rationality. His theory of morals therefore can serve a useful purpose only if his theory of rationality is sound. In this paper, I want to explore some of the more dubious aspects of that theory to see whether it can bear the heavy load of justification that “morals by agreement” places on it. (shrink)

The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review (...) within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students. (shrink)

Emergence of the novel pathogenic coronavirus SARS‐CoV‐2 and its rapid pandemic spread presents challenges that demand immediate attention. Here, we describe the development of a semi‐quantitative high‐content microscopy‐based assay for detection of three major classes (IgG, IgA, and IgM) of SARS‐CoV‐2 specific antibodies in human samples. The possibility to detect antibodies against the entire viral proteome together with a robust semi‐automated image analysis workflow resulted in specific, sensitive and unbiased assay that complements the portfolio of SARS‐CoV‐2 serological assays. Sensitive, specific (...) and quantitative serological assays are urgently needed for a better understanding of humoral immune response against the virus as a basis for developing public health strategies to control viral spread. The procedure described here has been used for clinical studies and provides a general framework for the application of quantitative high‐throughput microscopy to rapidly develop serological assays for emerging virus infections. (shrink)

Das Thema "menschliche Natur" hat eine lange Tradition in der Geschichte des philosophischen Denkens. Vor allem in Krisenzeiten und an Epochenschwellen stellte sich immer wieder Frage, was der Mensch "eigentlich" ist. Es sollte daher auch nicht überraschen, daß diese Frage auch in der Gegenwart wieder eine zunehmende Aufmerksamkeit findet. Nach langen Jahren eines nur zurückhaltenden Interesses findet die philosophische Anthropologie wieder stärkere Aufmerksamkeit. - Und doch handelt es dabei nicht nur um die Wiederaufnahme eines alten Themas. Die philosophische Beschäftigung mit (...) der menschlichen Natur hat im Zusammenhang mit den Fortschritten der modernen Bio- und Informationstechnologie eine unmittelbar praktische Relevanz bekommen, die sie in dieser Weise niemals zuvor hatte. Durch diese Fortschritte haben nämlich die Möglichkeiten technischer Eingriffe am Menschen eine Dimension erreicht, die nicht mehr nur einzelne seiner Merkmale manipulierbar macht, sondern seine "Natur" selbst. Dies gilt insbesondere im Hinblick auf die nicht mehr vollkommen utopische Idee eines genetischen Umbaus der gesamten Menschheit. Die Frage, die sich vor diesem Hintergrund stellt, ist die nach dem normativen Status der menschlichen Natur. Ist die psycho-physische Gestalt, in der wir den Menschen seit jeder kennen, ein Produkt zufälliger evolutionärer Prozesse und als solche moralisch neutral; oder ist sie intrinsisch wertvoll und daher schützenswert? Die in der Literatur geäußerten Meinungen zu dieser Frage gehen auseinander. Auf der einen Seite stehen diejenigen, die in der menschlichen Natur lediglich eine Tatsache sehen und keinen Grund erkennen können, weshalb diese Tatsache sakrosankt ein sollte. Unter bestimmten Voraussetzungen, so behaupten die Vertreter dieser Partei, kann es nicht nur legitim sein, die menschliche Natur zu verbessern, es kann sogar moralisch geboten sein. Auf der anderen Seite stößt genau diese Vorstellung einer technischen Rekonstruktion des Menschen auf Empörung und Abscheu. Abgesehen von allen Risiken, die mit einem solchen Herumbasteln verbunden sind, werde der Mensch auf diese Weise auf ein beliebiges "Stück Natur" reduziert; er werde zum totalen Objekt technischen Handelns und seiner Würde beraubt. Der menschlichen Natur müsse daher ein inhärenter Wert zugeschrieben werden, um den unverantwortlichen Plänen der Menschheitsverbesserer eine kategorische Grenze zu setzen. Doch was ist die "menschliche Natur"? Worin besteht sie und wie kann sie angesichts der unübersehbaren individuellen und kulturellen Vielfalt definiert werden? Dies ist die erste Frage, der die Beiträge des vorliegenden Bandes gewidmet sind. Und an sie schließt sich sogleich eine zweite an: Wenn es denn eine menschliche Natur gibt und wenn diese hinlänglich genau umrissen werden kann: Kann oder muß ihr dann ein moralischer Status zugeschrieben werden? Und welcher Art ist dieser Status: Ist er der menschlichen Natur inhärent oder leitet er sich von etwas anderem ab? -. (shrink)

In this paper I wish to discuss two types of moral judgment, the ascription of moral value and of moral worth. Such judgments attribute evaluative properties to persons. There can be little doubt that such judgments are frequently passed and that, though many people find them distasteful, they are indispensable to the effective operation of a morality. To take seriously the slogan ‘Judge not lest ye be judged’ is to treat morality as a private, personal matter, which is solely a (...) person’s own concern. But so taken, the slogan invites indiscriminate mutual condonation of, and so connivance at, immorality. I therefore ignore possible objections to such judgments on the grounds of their supposed illegitimacy. (shrink)

Probably no one has done more than Frankena to bring about the recent shift in philosophical interest from the primarily linguistic concerns of metaethics to what he calls “meta-morals,” that is, to questions about morality as a whole. Instead of investigating what so-called ethical terms stood for, or whether ethical utterances employed propositions or proposals or imperatives or whether they expressed feelings, beliefs, descriptions or prescriptions, or whether they conformed to ordinary propositional logic or to an imperatival or some other (...) logic of their own, Frankena set out to investigate the moral enterprise itself. Quite recently he put together the results of these reflections in two series of lectures, “Three Questions About Morality” and Thinking About Morality. My own views had always been very close to his, but these recent lectures, which for the first time put his thoughts on this topic together in a systematic way, have made clear to me that, while the starting point of our investigations is indeed the same, our conclusions diverge on a number of important points. I want to take up some of the problems to which we offer different solutions. (shrink)

Building upon a recent call to renew actor-network theory (ANT) for educational research, this article reconsiders relations between technology and educational theory. Taking cues from actor-network theorists, this discussion considers the technologically-mediated networks in which learning actors are situated, acted upon, and acting, and traces the novel positions of creative capacity and participation that emerging media may enable. Whereas traditional theories of educational technology tend to focus on the harmonization of new technologies with extant curricular goals and educational practices, an (...) educational theory of technology looks to novel forms of technologically-mediated learning experience—from production pedagogies to role play in the virtual—to make visible the surprising relations, techniques, and opportunities that emerging media, and their attendant social contexts, may offer educational research. (shrink)

Things make sense to us. The identity of a thing is a meaningful style that expresses the usability of the thing. The usability is a dynamic order of the praxis in which the thing is embedded and in which we are ourselves de-centered. According to Merleau-Ponty, this sociocultural and psychosocial order is a formation of practical understanding and interpretation that rests upon and resumes the elementary, perceptual-expressive structuring of being. The Spiel is one of the three dimensions of corporeal intentionality, (...) in which this entire organization of meaning and experience unfolds. So, the Spiel of usability is a corporeal and practical intentionality that reaches from an aesthetic-ontological structuring of meaning to the order of the things in modern everyday praxes. (shrink)

Dieser Band ist der erste Teil einer Lekture von Hegels Phanomenologie des Geistes, in dem die ersten drei Hauptkapitel - d.h. -Bewusstsein-, -Selbstbewusstsein- und -Vernunft- - von Hegels erstem Hauptwerk umfassend kommentiert werden. Der Text entstand dabei wahrend eines uber viele Jahre laufenden Seminars, welches am Institut fur Philosophie der Universitat Wien unter Leitung von Professor Dr. Friedrich Grimmlinger abgehalten wurde und in dem der Hegelsche Text gemeinsam Satz fur Satz gelesen und ausgelegt wurde.".

Revised habilitation - Universitèat, Wien.