The U.S. Food and Drug Administration's drug advisory committees provide expert assessments of the safety and efficacy of new therapies considered for approval. A committee hears from a variety of speakers, from six groups, including voting members of the committee, FDA staff members, employees of the pharmaceutical company seeking approval of a therapy, patient and consumer representatives, expert speakers invited by the company, and public participants. The committees convene at the request of the FDA when the risks and harms of (...) novel products are not immediately clear, and their final decisions carry significant weight, as most therapies that receive advisory committee approval are subsequently approved by the FDA. In recent years, across a series of diverse publications, the financial conflicts of interest of each category of participants in the meetings have been investigated. Here, we summarize these findings and their ethical implications, focusing on the FDA Oncologic Drugs Advisory Committee, and we suggest ways to move toward more transparent and impartial advisory committee meetings. (shrink)

Michael A. PetersBeijing Normal University, Beijing, PR China;There is an ecology of bad ideas, just as there is an ecology of weeds– Gregory Bateson (1972, p. 492)While there are classical anteced...

This paper explores relationships between environment and education after the Covid-19 pandemic through the lens of philosophy of education in a new key developed by Michael Peters and the Philosophy of Education Society of Australasia. The paper is collectively written by 15 authors who responded to the question: Who remembers Greta Thunberg? Their answers are classified into four main themes and corresponding sections. The first section, ‘As we bake the earth, let's try and bake it from scratch’, gathers wider (...) philosophical considerations about the intersection between environment, education, and the pandemic. The second section, ‘Bump in the road or a catalyst for structural change?’, looks more closely into issues pertaining to education. The third section, ‘If you choose to fail us, we will never forgive you’, focuses to Greta Thunberg’s messages and their responses. The last section, ‘Towards a new normal’, explores future scenarios and develops recommendations for critical emancipatory action. The concluding part brings these insights together, showing that resulting synergy between the answers offers much more then the sum of articles’ parts. With its ethos of collectivity, interconnectedness, and solidarity, philosophy of education in a new key is a crucial tool for development of post-pandemic education. (shrink)

Much has been published about the ethical issues encountered by clinicians in genetics/genomics, but those experienced by clinical laboratory scientists are less well described. Clinical laboratory scientists now frequently face navigating ethical problems in their work, but how they should be best supported to do this is underexplored. This lack of attention is also reflected in the ethics tools available to clinical laboratory scientists such as guidance and deliberative ethics forums, developed primarily to manage issues arising within the clinic.We explore (...) what ethical issues are being experienced by clinical scientists, how they think such issues could be best analysed and managed, and whether their practice might be enhanced by more situated approaches to ethics deliberation and practice such as ethical preparedness. From thematic analysis of cases presented by clinical scientists at a specially convened meeting of the UK Genethics Forum, we derived three main ethical themes: (1) the redistribution of labour and responsibilities resulting from the practice of genomic medicine; (2) the interpretation and certainty of results and (3) the proposal that better standardisation and consistency of ethical approaches (for example, more guidelines and policy) could resolve some of the challenges arising.We argue that although standardisation is important for promoting shared understandings of good (including ethical) practice, supplementary approaches to enhance and sustain ethical preparedness will be important to help clinical scientists and others in the recently expanded genetic/genomic medicine environment foster quality ethical thinking. (shrink)

This paper contains a critical examination of the prospects for analyses of knowledge that weaken the factivity condition such that knowledge implies approximate truth.

The food industry faces many significant risks from public criticism of corporate social responsibility (CSR) issues in the supply chain. This paper draws upon previous research and emerging industry trends to develop a comprehensive framework of supply chain CSR in the industry. The framework details unique CSR applications in the food supply chain including animal welfare, biotechnology, environment, fair trade, health and safety, and labor and human rights. General supply chain CSR issues such as community and procurement are also considered. (...) Ultimately, the framework serves as a comprehensive tool to support food industry practitioners and researchers in the assessment of strategic and operational supply chain CSR practices. (shrink)

This paper is a response to Baumann's comments on "Can Knowledge Really be Non-fative?" In this paper Baumann's suggestions for how those who deny the factivty of knowledge might deal with the argument from inconsistency and explosion are addressed.

_The Metaphysics of Perfect Beings_ addresses the problems an Anselmian perfect being faces in contexts involving unlimited options. Recent advances in the theory of vagueness, the metaphysics of multiverses and hyperspace, the theory of dynamic or sequential choice, the logic of moral and rational dilemmas, and metaethical theory provide the resources to formulate the new challenges and the Anselmian responses with an unusual degree of precision. Almeida shows that the challenges arising in the unusual contexts involving unlimited options sometimes produce (...) metaphysical surprise. (shrink)

This book is a sustained defense of the compatibility of the presence of idealizations in the sciences and scientific realism. So, the book is essentially a detailed response to the infamous arguments raised by Nancy Cartwright to the effect that idealization and scientific realism are incompatible.

The main question addressed in this paper is whether some false sentences can constitute evidence for the truth of other propositions. In this paper it is argued that there are good reasons to suspect that at least some false propositions can constitute evidence for the truth of certain other contingent propositions. The paper also introduces a novel condition concerning propositions that constitute evidence that explains a ubiquitous evidential practice and it contains a defense of a particular condition concerning the possession (...) of evidence. The core position adopted here then is that false propositions that are approximately true reports of measurements can constitute evidence for the truth of other propositions. So, it will be argued that evidence is only quasi-factive in this very specific sense. (shrink)

This is an editorial introduction to a special issue of Acta Analytica on epistemic luck.

The paper examines the problematic understanding of “risk” in entrepreneurial literature that locates courage in either the loss orgain of having or in the difficulty and hardship of the doing. We argue in this paper that what is lost in this vernacular view of courage is a deeper notion of the subjective dimension of work and the social need of society. Grounded within the Catholic social and moral tradition, we find a richer notion of courage, which in part corrects and (...) rounds out the insufficient description of the vernacular understanding of courage in entrepreneurship. What we also find in this account of the virtues and subjective dimension of work is greater explanatory power of what happens to the entrepreneur in the work that he or she does. The end result of this analysis is a more spiritual, ethical and social understanding of entrepreneurship. (shrink)

Some carnivores defend the position that the opportunistic consumption of meat is morally permissible even under the assumption that it is morally wrong to act in ways that ause unnecessary suffering to sentient beings. Ordering and consuming chicken once a week, they argue, will not increase the numbers of chickens suffering or slaughtered, since the system of purchasing and farming chickens is not sufficiently fine‐tuned to register differences at margin. We argue that, insensitivity of the market notwithstanding, consistent consequentialists are (...) morally prohibited from each additional purchase and consumption of meat. (shrink)

This essay analyzes the arguments justifying or opposing the notion of humanitarian intervention from realist and liberal perspectives and considers the difficulties of undertaking such interventions effectively and consistently.

This paper criticizes the pragma-dialectical conception of a fallacy, according to which a fallacy is an argumentative speech act which violates one or more of the rules of 'rational discussion'. That conception is found to be neither a necessary nor a sufficient condition for committing a fallacy. It is also found wanting in several other respects.

Over the last decade a handful of cognitive models of religious belief have begun to coalesce in the literature. Attempts to offer “scientific explanations of religious belief ” are nothing new, stretching back at least as far as David Hume, and perhaps as far back as Cicero. What is also not new is a belief that scientific explanations of religious belief serve in some way to undermine the justification for those beliefs.

Recently a number of variously motivated epistemologists have argued that knowledge is closely tied to practical matters. On the one hand, radical pragmatic encroachment is the view that facts about whether an agent has knowledge depend on practical factors and this is coupled to the view that there is an important connection between knowledge and action. On the other hand, one can argue for the less radical thesis only that there is an important connection between knowledge and practical reasoning. So, (...) defenders of both of these views endorse the view that knowledge is the norm of practical reasoning. This thesis has recently come under heavy fire and a number of weaker proposals have been defended. In this paper counter-examples to the knowledge norm of reasoning will be presented and it will be argued that this viewand a number of related but weaker viewscannot be sustained in the face of these counter-examples. The paper concludes with a novel proposal concerning the norm of practical reasoning that is immune to the counter-examples introduced here. (shrink)

The paper examines the problematic understanding of “risk” in entrepreneurial literature that locates courage in either the loss orgain of having or in the difficulty and hardship of the doing. We argue in this paper that what is lost in this vernacular view of courage is a deeper notion of the subjective dimension of work and the social need of society. Grounded within the Catholic social and moral tradition, we find a richer notion of courage, which in part corrects and (...) rounds out the insufficient description of the vernacular understanding of courage in entrepreneurship. What we also find in this account of the virtues and subjective dimension of work is greater explanatory power of what happens to the entrepreneur in the work that he or she does. The end result of this analysis is a more spiritual, ethical and social understanding of entrepreneurship. (shrink)

Property-identical divine-command theory (PDCT) is the view that being obligatory is identical to being commanded by God in just the way that being water is identical to being H2O. If these identity statements are true, then they express necessary a posteriori truths. PDCT has been defended in Robert M. Adams (1987) and William Alston (1990). More recently Mark C. Murphy (2002) has argued that property-identical divine-command theory is inconsistent with two well-known and well-received theses: the free-command thesis and the supervenience (...) thesis. I show that Murphy's argument is vitiated by mistaken assumptions about the substitutivity of metaphysical identicals in contexts of supervenience. The free-command thesis and the supervenience thesis therefore pose no serious threat to PDCT. (Published Online August 11 2004). (shrink)

Van Fraassen’s (1989) infamous best of a bad lot objection is widely taken to be the most serious problem that afflicts theories of inference to the best explanation (IBE), for it alleges to show that we should not accept the conclusion of any case of such reasoning as it actually proceeds. Moreover, this is supposed to be the case irrespective of the details of the particular criteria used to select best explanations. The best of a bad lot objection is predicated (...) on, and really only requires, the idea that in any real case of IBE where one hypothesis is favored as best over those with which it competes, it is always the case that it is more likely that the true explanation is to be found in the set of unformulated and unconsidered logical alternatives to the set of actually considered hypotheses. On this basis, Van Fraassen believes that accepting the conclusion of IBEs so understood is irrational and this is simply because such inferences are supposedly not probative. In this paper the best of a bad lot objection will be addressed and it will be shown that Van Fraassen’s notorious criticism of IBE depends on a problematic conflation of two notions of rationality and thus that his criticism of IBE involves a damning equivocation. In essence, he conflates ideal standards of rationality with epistemic standards of rationality and, in so doing, makes it appear to be the case that we should not accept the conclusions of IBEs. But, when we disambiguate the concepts of rationality at work in the argument Van Fraassen’s conclusion simply does not follow. (shrink)

We highlight connections between accessible categories and abstract elementary classes , and provide a dictionary for translating properties and results between the two contexts. We also illustrate a few applications of purely category-theoretic methods to the study of AECs, with model-theoretically novel results. In particular, the category-theoretic approach yields two surprising consequences: a structure theorem for categorical AECs, and a partial stability spectrum for weakly tame AECs.

This paper introduces a new argument for the safety condition on knowledge. It is based on the contention that the rejection of safety entails the rejection of the factivity condition on knowledge. But, since we should maintain factivity, we should endorse safery.

In this paper Timothy Williamson’s argument that the knowledge norm of assertion is the best explanation of the unassertability of Morrean sentences is challenged and an alternative account of the norm of assertion is defended.

This paper introduces a new argument against Richard Foley’s threshold view of belief. His view is based on the Lockean Thesis (LT) and the Rational Threshold Thesis (RTT). The argument introduced here shows that the views derived from the LT and the RTT violate the safety condition on knowledge in way that threatens the LT and/or the RTT.

Following Nancy Cartwright and others, I suggest that most (if not all) theories incorporate, or depend on, one or more idealizing assumptions. I then argue that such theories ought to be regimented as counterfactuals, the antecedents of which are simplifying assumptions. If this account of the logic form of theories is granted, then a serious problem arises for Bayesians concerning the prior probabilities of theories that have counterfactual form. If no such probabilities can be assigned, the the posterior probabilities will (...) be undefined, as the latter are defined in terms of the former. I argue here that the most plausible attempts to address the problem of probabilities of conditionals fail to help Bayesians, and, hence, that Bayesians are faced with a new problem. In so far as these proposed solutions fail, I argue that Bayesians must give up Bayesianism or accept the counterintuitive view that no theories that incorporate any idealizations have ever really been confirmed to any extent whatsoever. Moreover, as it appears that the latter horn of this dilemma is highly implausible, we are left with the conclusion that Bayesianism should be rejected, at least as it stands. (shrink)

In this paper it is argued that three of the most prominent theories of conditional acceptance face very serious problems. David Lewis' concept of imaging, the Ramsey test and Jonathan Bennett's recent hybrid view all face viscious regresses, or they either employ unanalyzed components or depend upon an implausibly strong version of doxastic voluntarism.

We develop a framework for assessing security market quality, relating five elements of market design to three metrics of market integrity and two metrics of market efficiency. We empirically implement this integrity–efficiency MQ framework by testing a hypothesis that trade-based ramping manipulation at the close raises execution costs on 24 security markets worldwide. Estimating a simultaneous equations model of ramping incidence, spreads, and the probability of deploying real-time surveillance, we show that quoted bid-ask spreads are positively related to the incidence (...) of MTC across seven liquidity deciles. The magnitude is economically significant; improving market integrity by cutting MTC in half reduces spreads 6–11 %. Allowing direct market access in conjunction with RTS, conducting auctions at the close, and developing regulations that require surveillance, all reduce MTC and thereby lower spreads, assuring better market integrity and enhancing market efficiency. Introducing circuit breakers or prohibiting shorts poses integrity–efficiency tradeoffs. (shrink)

Defenders of doxastic voluntarism accept that we can voluntarily commit ourselves to propositions, including belief-contravening propositions. Thus, defenders of doxastic voluntarism allow that we can choose to believe propositions that are negatively implicated by our evidence. In this paper it is argued that the conjunction of epistemic deontology and doxastic voluntarism as it applies to ordinary cases of belief-contravening propositional commitments is incompatible with evidentialism. In this paper ED and DV will be assumed and this negative result will be used (...) to suggest that voluntary belief-contravening commitments are not themselves beliefs and that these sorts of commitments are not governed by evidentialism. So, the apparent incompatibility of the package views noted above can be resolved without ceding evidentialism with respect to beliefs. (shrink)

Paradoxes have played an important role both in philosophy and in mathematics and paradox resolution is an important topic in both fields. Paradox resolution is deeply important because if such resolution cannot be achieved, we are threatened with the charge of debilitating irrationality. This is supposed to be the case for the following reason. Paradoxes consist of jointly contradictory sets of statements that are individually plausible or believable. These facts about paradoxes then give rise to a deeply troubling epistemic problem. (...) Specifically, if one believes all of the constitutive propositions that make up a paradox, then one is apparently committed to belief in every proposition. This is the result of the principle of classical logical known as ex contradictione (sequitur) quodlibetthat anything and everything follows from a contradiction, and the plausible idea that belief is closed under logical or material implication (i.e. the epistemic closure principle). But, it is manifestly and profoundly irrational to believe every proposition and so the presence of even one contradiction in one’s doxa appears to result in what seems to be total irrationality. This problem is the problem of paradox-induced explosion. In this paper it will be argued that in many cases this problem can plausibly be avoided in a purely epistemic manner, without having either to resort to non-classical logics for belief (e.g. paraconsistent logics) or to the denial of the standard closure principle for beliefs. The manner in which this result can be achieved depends on drawing an important distinction between the propositional attitude of belief and the weaker attitude of acceptance such that paradox constituting propositions are accepted but not believed. Paradox-induced explosion is then avoided by noting that while belief may well be closed under material implication or even under logical implication, these sorts of weaker commitments are not subject to closure principles of those sorts. So, this possibility provides us with a less radical way to deal with the existence of paradoxes and it preserves the idea that intelligent agents can actually entertain paradoxes. (shrink)

I provide a critique of Axel Honneth’s theory of recognition by calling into question the extent to which recognitive relations are immune to the effects of social and economic power and their ability to shape consciousness and moral cognition. I maintain that as a theory of socialization, Honneth’s theory is inadequate to deal with the strong structural-functional forces that hold administrative-capitalist societies together. This has the effect of constituting subjectivity in particular ways, and this problem of the constitution of the (...) personality and consciousness of individuals vitiates the descriptive and normative claims of the theory of recognition. I end by considering an alternative way to view recognition and its role in promoting a form of critical subjectivity. (shrink)

In recent years a number of sophisticated versions of soteriological universalism have appeared in the literature. In this essay I offer some critical retlections them. In particular, I argue that universalism offers no explanation for the fact that God puts human creatures through the earthly life, and that if there is no such reason then the earthly life and the evil it contains are both gratuitous. Finally, I argue that universalists are obliged to deny that human beings have a centrally (...) important feature of human freedom. (shrink)

This paper is an insighful critique of the shareholder and stakeholder models of organizational purpose. The authors emphasize that both these models fail to serve as an adequate basis for explaining the purpose of an organization and are unable to capture a fuller meaning of living in an organizational community. The paper thus endeavours to introduce into the mainstream of discussion a third model, based on the idea of the common good which draws inspiration from the communitarian Catholic tradition. The (...) first part of this paper traces the idea of common good as it relates to organizations. The second part engages the common good tradition with the shareholder and stake holder models. The paper goes on to describe common good within the organization through three propositions: fundamentality, excellence and integration. The authors reiterate, however, that the idea of the common good does not provide a micro-blueprint for managers, but rather an orientation or moral compass that directs organizational activity towards human development. (shrink)

The book gives a diverse and even-handed treatment of the topic without attempting to resolve the matter.

We introduce a family of rank functions and related notions of total transcendence for Galois types in abstract elementary classes. We focus, in particular, on abstract elementary classes satisfying the condition known as tameness, where the connections between stability and total transcendence are most evident. As a byproduct, we obtain a partial upward stability transfer result for tame abstract elementary classes stable in a cardinal $\lambda$ satisfying $\lambda^{\aleph_{0}}\gt \lambda$, a substantial generalization of a result of Baldwin, Kueker, and VanDieren.

In this article the standard philosophical method involving intuition-driven conceptual analysis is challenged in a new way. This orthodox approach to philosophy takes analysanda to be the specifications of the content of concepts in the form of sets of necessary and sufficient conditions. Here it is argued that there is no adequate account of what necessary and sufficient conditions are. So, the targets of applications of the standard philosophical method so understood are not sufficiently well understood for this method to (...) be dependable. (shrink)

In a recent article, Peter Gärdenfors (1992) has suggested that the AGM (Alchourrón, Gärdenfors, and Makinson) theory of belief revision can be given an epistemic basis by interpreting the revision postulates of that theory in terms of a version of the coherence theory of justification. To accomplish this goal Gärdenfors suggests that the AGM revision postulates concerning the conservative nature of belief revision can be interpreted in terms of a concept of epistemic entrenchment and that there are good empirical reasons (...) to adopt this view as opposed to some form of foundationalist account of the justification of our beliefs. In this paper I argue that Gärdenfors’ attempt to underwrite the AGM theory of belief revision by appealing to a form of coherentism is seriously inadequate for several reasons. (shrink)

In this paper we argue that dissociative identity disorder (DID) is best interpreted as a causal model of a (possible) post-traumatic psychological process, as a mechanical model of an abnormal psychological condition. From this perspective we examine and criticize the evidential status of DID, and we demonstrate that there is really no good reason to believe that anyone has ever suffered from DID so understood. This is so because the proponents of DID violate basic methodological principles of good causal modeling. (...) When every ounce of your concentration is fixed upon blasting a winged pig out of the sky, you do not question its species' ontological status. James Morrow, City of Truth (1990). (shrink)