The U.S. Food and Drug Administration's drug advisory committees provide expert assessments of the safety and efficacy of new therapies considered for approval. A committee hears from a variety of speakers, from six groups, including voting members of the committee, FDA staff members, employees of the pharmaceutical company seeking approval of a therapy, patient and consumer representatives, expert speakers invited by the company, and public participants. The committees convene at the request of the FDA when the risks and harms of (...) novel products are not immediately clear, and their final decisions carry significant weight, as most therapies that receive advisory committee approval are subsequently approved by the FDA. In recent years, across a series of diverse publications, the financial conflicts of interest of each category of participants in the meetings have been investigated. Here, we summarize these findings and their ethical implications, focusing on the FDA Oncologic Drugs Advisory Committee, and we suggest ways to move toward more transparent and impartial advisory committee meetings. (shrink)

Michael A. PetersBeijing Normal University, Beijing, PR China;There is an ecology of bad ideas, just as there is an ecology of weeds– Gregory Bateson (1972, p. 492)While there are classical anteced...

This paper explores relationships between environment and education after the Covid-19 pandemic through the lens of philosophy of education in a new key developed by Michael Peters and the Philosophy of Education Society of Australasia. The paper is collectively written by 15 authors who responded to the question: Who remembers Greta Thunberg? Their answers are classified into four main themes and corresponding sections. The first section, ‘As we bake the earth, let's try and bake it from scratch’, gathers wider (...) philosophical considerations about the intersection between environment, education, and the pandemic. The second section, ‘Bump in the road or a catalyst for structural change?’, looks more closely into issues pertaining to education. The third section, ‘If you choose to fail us, we will never forgive you’, focuses to Greta Thunberg’s messages and their responses. The last section, ‘Towards a new normal’, explores future scenarios and develops recommendations for critical emancipatory action. The concluding part brings these insights together, showing that resulting synergy between the answers offers much more then the sum of articles’ parts. With its ethos of collectivity, interconnectedness, and solidarity, philosophy of education in a new key is a crucial tool for development of post-pandemic education. (shrink)

This paper argues that Moore’s principle of organic unities is false. Advocates of the principle have failed to take note of the distinction between actual intrinsic value and virtual intrinsic value. Purported cases of organic unities, where the actual intrinsic value of a part of a whole is allegedly defeated by the actual intrinsic value of the whole itself, are more plausibly seen as cases where the part in question has no actual intrinsic value but instead a plurality of merely (...) virtual intrinsic values. (shrink)

Many writers accept the following thesis about responsibility: (R) For one to be responsible for something is for one to be such that it is fitting that one be the object of some reactive attitude with respect to that thing. This thesis bears a striking resemblance to a thesis about value that is also accepted by many writers: (V) For something to be good (or neutral, or bad) is for it to be such that it is fitting that it be (...) the object of some pro-attitude (or indifference, or some contra-attitude). V has been the subject of intense debate in recent years, in part because of its incorporation into what has come to be called the “buck-passing” account of value. In particular, V is open to three challenges: that it is not necessarily the case that whatever is good is the fitting object of a pro-attitude; that it is not necessarily the case that whatever is the fitting object of a pro-attitude is good; and that, even if there is a strict equivalence between what is good and what is the fitting object of a pro-attitude, still the former is not to be analyzed in terms of the latter. The resemblance between V and R has not been previously commented on, but, once it is recognized, it is clear that R is open to challenges that resemble those to which V is vulnerable. This paper explores both the challenges to V and the parallel challenges to R and discusses responses that may be given to these challenges. The interrelation between V and R is then examined, and a general lesson is drawn concerning how to adjudicate disputes about the nature of moral responsibility. (shrink)

Kent Bach has argued that certain traditional problems of action theory (conceming the individuation of actions, their timing, their location, and the manner in which they enter into causal relations) arise only on the supposition that actions are events, and he has argued further that actions are not events. In this paper these arguments are examined and rejected.

Most compatibilists have sought to defend their view by means of an analysis of the concept of ‘can’ in terms of subjunctive conditionals. Keith Lehrer opposes this analysis; he nevertheless embraces compatibilism. In a recent paper he has proposed a novel analysis of the concept of ‘can’ within the framework of possible-world semantics. The paper has provoked considerable discussion. In it Lehrer claims that he demonstrates the truth of compatibilism. Others have claimed that this is not so, but at least (...) one commentator has asserted that Lehrer's analysis strongly supports compatibilism. In this section I shall give a brief exposition of relevant portions of Lehrer's account of ‘can’ and then in the next section I shall seek to show that it fails to render compatibilism any more plausible than incompatibilism. Indeed, I shall seek to show that, if one of Lehrer's primitive concepts is understood as it seems it should be understood, then there would seem to be good reason to believe that his analysis supports not compatibilism but incompatibilism. (shrink)

Clarke's book on omissions is rich and subtle, filled with nuance and insight. It is chock-full of arguments, and helpful illustrations to back up these arguments, and it covers a lot of ground ver...

In lieu of an abstract, here is a brief excerpt of the content:Jesus the World-Protector:Eighteenth-Century Gelukpa Historians View Christianity1Michael J. SweetThe assumption that religion was so seamlessly woven into non-Western and preindustrial cultures that it was not even distinguished as a separate entity, let alone regarded as an object for study, has been a commonplace among Western scholars of religion for some decades.2 From this point of view, which can be broadly characterized as postmodernist and postcolonialist, the concept of religion (...) "is not a native category... it is a category imposed from outside... it is the other... colonialists who are solely responsible for the content of the term."3 This is a somewhat reductionistic and Eurocentric perspective that ignores the universal human capacity to empathically understand other belief systems.One counterexample to this school of thought is found in the works of three eighteenth-century religious historians, all of whom were learned monks in the Gelukpa tradition of Tibetan Buddhism: Gombojab (Mgon po Skyabs, late seventeenth century–after 1766),4 Sumba Khembo (Sum pa Mkhan po Yes shes dpal 'byor, 1704–1776), and Tuken (Thu'u Bkwan Blo bzang Chos kyi Nyi ma, 1737– 1802), authors of The History of Buddhism in China, The Auspicious Wish-Fulfilling Tree,5 and The Crystal Mirror,6 respectively. These scholars had clear conceptions of their own and other religious systems (Tib.: chos lugs), and compared to earlier Tibetan accounts they present relatively tolerant evaluations of other religious philosophies—for example, Chinese Buddhism, Daoism, and the Literati Tradition (Ru jiao, "Confucianism")—while asserting the superiority of the Gelukpa form of Tibetan Buddhism.7As a case in point, we will see how they describe and evaluate Christianity, a religion that was quite foreign to them and that they appear to have understood only imperfectly. Earlier Tibetan Buddhist religious histories, of which the best-known are the Blue Annals of 'Gos Lotsawa and Bu ston's "History of the Dharma," are immensely valuable sources, but they are more parochial in their range of interest than those of the eighteenth-century Tibeto-Mongol scholars.8 For the earlier historians Indo-Tibetan Buddhism was the only religious system worth serious consideration, and Chinese Buddhism, Indian non-Buddhist religious philosophies, Bon, [End Page 173] and Islam were dealt with in a polemical or (especially in the case of Islam) a frankly hostile fashion. Something changed in the eighteenth century that produced works closer to modern comparative religion than to medieval heresiography.A major motive for this shift was surely the triumph of the Manchu Qing dynasty, which by the mid-eighteenth century had incorporated Tibet and Mongolia definitively into its sphere. Thus, the horizon of the Tibeto-Mongol intelligentsia widened to include the vast Manchu empire, whose leadership in its turn was becoming increasingly aware of other Asian societies and of the European colonial powers. I believe it is significant that Sumba Khembo, Tuken, and Gombojab were all of Mongol ethnicity, the first two from Amdo and the last from Mongolia; they were able to combine an encyclopedic mastery of Tibetan Buddhist texts and ritual with the greater objectivity available to people stemming from the geographical and cultural periphery of that tradition. All three of them were exposed to the cosmopolitan world of imperial Beijing, where they had ample opportunity to meet followers of non-Buddhist religions of a wide range of ethnicities.9By the mid-eighteenth century there were four Catholic churches in Beijing, serving thousands of Chinese Christian converts. Dozens of European priests were employed by the imperial court as well.10 The prevailing syncretic view of the three major Chinese religious philosophies (sanjiao)—Buddhism, Daoism, and the Literati Tradition—as being mutually complementary,11 prevailed in the capital. This is the view that is approvingly cited by Tuken: "there are three great traditions (lugs srol) which clarify the ultimate nature of things, the Literati Tradition, Daoism, and Buddhism."12In turning to these scholars' treatment of Christianity, we find the earliest notice of this religion in Gombojab's History of Buddhism in China,13 written around the mid-1730s.14 Gombojab renders the name of Jesus in its traditional Chinese form of Yesu; he is called the World... (shrink)

B.-C. Bazán a déterminé récemment que les Questiones de anima de Thomas d’Aquin le conduisaient à s’éloigner de la représentation de l’âme comme substance, et qu’elles étaient antérieures à la Summa theologiae I Pars. Cette étude examine l’idée d’âme comme substance chez Thomas d’Aquin et éclaire les résultats de Bazán en montrant que Thomas utilise deux méthodes anthropologiques différentes, l’une philosophique et l’autre théologique.

This paper criticizes the pragma-dialectical conception of a fallacy, according to which a fallacy is an argumentative speech act which violates one or more of the rules of 'rational discussion'. That conception is found to be neither a necessary nor a sufficient condition for committing a fallacy. It is also found wanting in several other respects.

This paper begins by pointing out that the Aristotelian conception of continuity (synecheia) and the contemporary topological account share the same intuitive, proto-topological basis: the conception of a ?natural whole? or unity without joints or seams. An argument of Aristotle to the effect that what is continuous cannot be constituted of ?indivisibles? (e.g., points) is examined from a topological perspective. From that perspective, the argument fails because Aristotle does not recognize a collective as well as a distributive concept of a (...) multiplicity of points. It is the former concept that allows contemporary topology to identify some point sets with spatial regions (in the proto-topological sense of this term). This identification, in turn, allows contemporary topology to do what Aristotle was unwilling to do: to conceive the property of continuity, as well as the properties of having measure greater than zero and having n- dimension, as emergent properties. Thus, a point set can be continuous (connected) although none of its subsets of sufficiently smaller cardinality can be. Finally, the paper discusses the manner in which a topological principle, viz., the principle that none of the singletons of points of a continuum can be open sets of that continuum, captures certain aspects of the Aristotelian proto-topological conception of the relation between points and continua. E.g., for both Aristotle and contemporary topology, points in a continuum exist simple as limits of the remainder of the continuum: their singletons have empty ?interiors? and, hence, they are not ?chunks? (topologically, regular closed set) of the continuum. (shrink)

This paper is a critical assessment of argumentum ad baculum, or appeal to force. Its principal contention is that, contrary to common opinion, there is no general fallacy of ad baculum. Most real-life ad baculums are, in fact, fairly strong. A basic logical form for reconstructed ad baculums is proposed, and a number of heterodoxical conclusions are also advanced and argued for. They include that ad baculum is not necessarily a prudential argument, that ad baculum need not involve force, violence, (...) or threats, and that one can argue ad baculum to oneself. The starting point of the paper, however, is a critical evaluation of three ad baculums from the exercise sets of Irving Copi's well-known Introduction to Logic. (shrink)

Partisan or Neutral? critically examines the Rawlsian ideal of a public, supposedly neutral, political theory meant to justify contemporary constitutional democracies. Placing this ideal-appealed to by neo-natural law theorists and advocates of "public theology" as well as by political theorists-against the background of the history of political liberalism, White shows its contradictory nature. He argues that any such legitimating theory will be 'partisan,' in the sense of appealing to convictions concerning the human good that will not be universally accepted. He (...) concludes that all politics must be imperfect-a matter of pragmatism and prudence in forming the most workable compromises possible and in acquiescing, where our principles allow us to do so, in situations that are often far from optimal. (shrink)

A well-known epigram by Callimachus on the philosopher Diodorus Cronus reads as follows:The question of the third line, while perhaps recondite from a contemporary perspective, was clear in antiquity. The crows are asking ‘What follows ?’, in allusion to the Hellenistic disputes concerning the truth conditions of conditional propositions , disputes in which the views of Diodorus figured prominently.I agree with Sedley that the question of the last line is ‘much more problematic’. The common interpretation has been to read the (...) αθι as a form of αθις and to interpret it temporally. The result, in Pfeiffer's estimation, is ‘quomodo posthac erimus?’.This interpretation derives from Sextus Empiricus' discussion at M. 1.309–12 of the last two lines of the epigram. After crediting the grammarian with the ability to understand the allusion in the crows' first question , he proceeds to argue that the philosopher has a better chance than the grammarian of understanding the second question. But, to quote Sedley, Sextus ‘makes a ghastly mess of it’ when he attempts his own elucidation. According to an argument of Diodorus, a living thing does not die in the time in which it lives nor in a time in which it does not live. Hence, Sextus concludes, it must be the case that it never dies and, ‘if this is the case, we are always living and, according to him, we shall come to be hereafter ’. (shrink)

Helping scientists and engineers challenge received assumptions about how science, engineering, and society relate is a critical cornerstone for macroethics education. Scientific and engineering research are frequently framed as first steps of a value-free linear model that inexorably leads to societal benefit. Social studies of science and assessments of scientific and engineering research speak to the need for a more critical approach to the noble intentions underlying these assumptions. “Science Outside the Lab” is a program designed to help early-career scientists (...) and engineers understand the complexities of science and engineering policy. Assessment of the program entailed a pre-, post-, and 1 year follow up survey to gauge student perspectives on relationships between science and society, as well as a pre–post concept map exercise to elicit student conceptualizations of science policy. Students leave Science Outside the Lab with greater humility about the role of scientific expertise in science and engineering policy; greater skepticism toward linear notions of scientific advances benefiting society; a deeper, more nuanced understanding of the actors involved in shaping science policy; and a continued appreciation of the contributions of science and engineering to society. The study presents an efficacious program that helps scientists and engineers make inroads into macroethical debates, reframe the ways in which they think about values of science and engineering in society, and more thoughtfully engage with critical mediators of science and society relationships: policy makers and policy processes. (shrink)