Idiopathic Parkinson’s disease impairs working memory, but the exact nature of this deficit in terms of the underlying cognitive mechanisms is not well understood. In this study patients with mild clinical symptoms of PD were compared with matched healthy control subjects on a computerized battery of tests designed to assess spatial working memory and verbal working memory. In the spatial working memory task, subjects were required to recall a sequence of four locations. The verbal working memory task was methodologically identical (...) except for the modality of the stimuli used, requiring subjects to orally recall a sequence of six digits. In either case, half of the sequences were structured in a way that allowed ‘chunking’, while others were unstructured. This manipulation was designed to dissociate the strategic component of task performance from the memory-load component. Mild medicated patients with PD were impaired only on the structured versions of the verbal working memory tasks. The analogous deficit in the spatial working memory was less pronounced. These findings are in agreement with the hypothesis that working memory deficits in PD reflect mainly the executive component of the tasks and that the deficits may be at least partly modality-independent. (shrink)

Technologies for human germ‐line modification may soon enable humanity to create new types of human beings. Decisions about use of this power entail an unprecedented combination of difficulties: the stakes are immense, the unknowns are daunting, and moral principles are called into question. Evolved morality is not a sure basis for these decisions, both because of its inherent imperfections and because genetic engineering could eventually change humans’ innate cognitive mechanisms. Nevertheless, consensus is needed on moral values relevant to germ‐line modification. (...) These values could be based on characteristics of human beings that would remain constant regardless of revised genomes. (shrink)

Love's bitter fruits: Martha C. Nussbaum The Therapy of Desire: Theory and Practice in Hellenistic Ethics.Max Horkheimer, Between Philosophy and Social Science: Selected Early Writings.

This book presents the theory of capital utilization, a discussion of the econometrics of capital utilization, and econometric tests of the theory using international data. Capital utilization, defined as the proportion of time that capital is working productively, is mainly affected by shift-working. Capital utilization is an important economic variable that has received serious attention from economists only since the mid-1960s In the first part, the authors provide a synthesis of current knowledge, combining a consistent statement of existing theory with (...) some major extensions. In the second part, they turn to the econometrics, first discussing the appropriate methodology and then testing the theory on data from several countries. This empirical work is considerably more sophisticated than previous studies on this topic. Having established the theory and tested it, they move on to consider policy, the relationship between capital utilization and economic growth, and the place of shift-work in the dual economy. (shrink)

This article seeks to clarify the relation between arguments for atheism and descriptions of the summum bonum in Indian Buddhism, through the analysis of one influential text. I begin by noting that a number of writers have detected a tension between, on the one hand, Buddhist refutations of the existence of “God” (īśvara, ātman, puruşa) and, on the other, Buddhist (especially Mahāyāna) claims about the nature of the ultimate (nirvāna, buddha, dharmakāya), which often appears to have God-like qualities. I then (...) turn to a locus classicus of Mahāyāna Buddhist philosophy of religion, the Pramānasiddhi (“Establishment of Authority”) chapter of the Pramānāvarttika (“Commentary on Authority”) of Dharmakīrti (7th century CE). After briefly introducing Dharmakīrti and the Pramānasiddhi chapter, I examine first the chapter’s atheological passages, which include a systematic attack on a Hindu (Nyāya) “argument from design” and a number of important claims about the implausibility of any permanent “spiritual” principle. The arguments are complex and varied, but most turn on the crucial Buddhist assumption that a permanent entity is by definition incapable of interaction with the impermanent, hence utterly unsuitable as a cause or effect. I then examine the chapter’s buddha logical passages, which tend to stress that a Buddha is defined above all by his knowledge of what is to be avoided and adopted by those intent on freedom, i.e., his knowledge of the four noble truths. The Buddha thus described is less notable for his transcendental nature than for his wise, compassionate, and skillful engagement with the world and its creatures---hence less obviously Mahāyānist than the Buddha described by those who articulate a “three-body” (trikāya) theory. I note by way of conclusion that, though Dharmakīrti’s buddhalogy did not prove as influential as his atheology, the juxtaposition of the two reveals an overall metaphysical consistency, in which axiomatic assumptions about permanence, impermanence, and deity are in harmony rather than tension. (shrink)

Beyond Language and Reason: Mysticism in Indian Buddhism Ilkka Pyysiäinen, 1993 Annales Academiæ Scientiarum Fennicæ Dissertationes Humanarum Litterarum 66 Helsiniki, Sumolainen Tiedeakatemia.

Abstract The tshogs zhing, or field of assembly, is an important subject in Tibetan religious art. Typically, it focuses on one's own guru, seated at the crest of a great tree, with the gurus preceding him ranged in the sky above him and the deities of one's tradition ranged on the tree below him. The tshogs zhing is an object of visualisation in Tibetan guru yoga practices, and serves as both a ?map? of the Tibetan sacred cosmos and as an (...) index of the guru's crucial role in the tradition as a mediator between the practitioner on the one hand and the diachronic lineage of teachers and the synchronie pantheon of deities, on the other. (shrink)

Aim: Participation in classroom physical activity breaks may improve children’s cognition, but few studies have involved adolescents. The primary aim of this study was to examine the effects of classroom-based resistance training with and without cognitive training on adolescents’ cognitive function.Methods: Participants were 97 secondary school students. Four-year 10 classes from one school were included in this four-arm cluster randomized controlled trial. Classes were randomly assigned to the following groups: sedentary control with no cognitive training, sedentary with cognitive training, resistance (...) training without cognitive training, and resistance training with cognitive training. Sessions varied in levels of both cognitive demand and resistance training and were administered three times per week for 4 weeks. Inhibition, cognitive flexibility, episodic memory, on-task behavior, and muscular fitness were assessed at baseline and post-test. Linear mixed models were used to examine changes within and between groups.Results: In comparison with the control group, episodic memory improved significantly in the resistance training without cognitive training group. There were no group-by-time effects for inhibition or cognitive flexibility. Classroom activity breaks both with and without cognitive demand improved participants’ on-task behavior in comparison with the control and sedentary group. The resistance training programs did not lead to improvements in muscular fitness.Conclusion: Participation in body weight resistance training without cognitive training led to selective improvements in episodic memory. No training effects were found for inhibition or cognitive flexibility. A longer study period may be necessary to induce improvements in muscular fitness and associated changes in inhibition and cognitive flexibility.Clinical Trial Registration:https://www.anzctr.org.au/ACTRN12621001341819.aspx, Australian New Zealand Clinical Trials Registry—ACTRN12621001341819. (shrink)

This volume presents new work in history and historiography to the increasingly broad audience for studies of the history and philosophy of science. These essays are linked by a concern to understand the context of early modern science in its own context.

Since the revival of historicist philosophy of science in the 1960s many philosophers have acknowledged a debt to Duhem. But Duhem’s opinions are imperfectly understood and, as McMullin has shown in his (1970) and (1979), there are many strands in the current revival of historicism. We consider here Duhem’s views on the role of history in the appraisal of scientific theories. However, there is no single text offering Duhem’s views on the subject; rather, they are revealed during their application to (...) various historical and contemporary cases. Duhem’s most sustained examination of a contemporary case is his critique of Maxwell’s science and scientific methodology.Duhem’s critique of Maxwell is not a set of isolated or incidental dicta, but the expression of Duhem’s mature thought over the last quarter-century of his life, ranging from (at least) 1893 to his death in 1916. (shrink)

We examine Duhem's critique of Maxwell, especially Duhem's complaints that Maxwell's theory is too bold or not systematic enough, that it is too dependent on models, and that its concepts are not continuous with those of the past. We argue that these complaints are connected by Duhem's historical criterion for the evaluation of physical theories. We briefly compare Duhem's criterion of historical continuity with similar criteria developed by "historicists" like Kuhn and Lakatos. We argue that Duhem's rejection of theoretical pluralism (...) was a primary factor preventing him from recognizing Maxwell's work as an autonomous tradition. (shrink)

The format of this book is unusual, especially for a book about linguistics. The book is meant primarily as a research monograph aimed at linguists who have some background in formal semantics, e. g. Montague Grammar. However, I have two other audiences in mind. Linguists who have little or no experience of formal semantics, but who have worked through a basic mathematics for linguists course (e. g. using Wall, 1972, or Partee, 1978), should, perhaps with the help of a sympathetic (...) Montague gramma rian, be able to discover enough of how I have adapted some of the basic ideas in formal semantics to make the developments that I undertake in the rest of the book accessible. Logicians and computer scientists who know about model theoretic semantics and formal systems should be able to glean enough from Chapters I and II about linguistic concerns and techniques to be able to read the remainder of the book, again possibly with the help of a sympathetic Montague grammarian. However, readers should beware. Chapter II is not meant as a general introduction either to formal semantics or to linguistics and while much of the presentation there is going over ground that is already well covered in the literature, the particular formulation and the emphases are very much oriented to the developments to be undertaken later in the book. (shrink)

We argue that in contemporary business organizations, in which fundamental purpose is construed to be increased value—especially in ‘participative’ organizations, in which non–hierarchal interaction (for example, work teams) is the norm; and in ‘adaptive’ organizations, in which unpredictable change is the rule—a process of values covenanting will be much more valueable than just espoused values or even values covenants. We propose such a process model for organizational values covenanting and argue that such covenanting reflects an anthropomorphism of the human character (...) development process, validated in terms of the theory of viable systems. (shrink)

In two studies, we explored the frequency and phenomenology of musical imagery. Study 1 used retrospective reports of musical imagery to assess the contribution of individual differences to imagery characteristics. Study 2 used an experience sampling design to assess the phenomenology of musical imagery over the course of one week in a sample of musicians and non-musicians. Both studies found episodes of musical imagery to be common and positive: people rarely wanted such experiences to end and often heard music that (...) was personally meaningful. Several variables predicted musical imagery, including personality, musical preferences, and positive mood. Musicians tended to hear musical imagery more often, but they reported less frequent episodes of deliberately-generated imagery. Taken together, the present research provides new insights into individual differences in musical imagery, and it supports the emerging view that such experiences are common, positive, and more voluntary than previously recognized. (shrink)

: We question the claim, common since Duhem, that sixteenth century astronomy, and especially the Wittenberg interpretation of Copernicus, was instrumentalistic rather than realistic. We identify a previously unrecognized Wittenberg astronomer, Edo Hildericus (Hilderich von Varel), who presents a detailed exposition of Copernicus's cosmology that is incompatible with instrumentalism. Quotations from other sixteenth century astronomers show that knowledge of the real configuration of the heavens was unattainable practically, rather than in principle. Astronomy was limited to quia demonstrations, although demonstration propter (...) quid remained the ideal. We suggest that Osiander's notorious preface to Copernicus expresses these sixteenth century commonplaces rather than twentieth century instrumentalism, and that neither `realism', nor `instrumentalism', in their modern meanings, apply to sixteenth century astronomy. (shrink)

Parkinson’s disease (PD) is a common neurodegenerative disorder of the nervous system that affects about 1 in 800 people and for which we have symptomatic but not curative therapies. At the core of the disease is the loss of a specific population of dopaminergic neurons within the brain, and replacement of dopamine through drug therapies has provided clinically significant benefit for many patients. However this therapy only ever offers a temporary amelioration of symptoms and with time this symptomatic therapy becomes (...) less efficacious and produces its own unique side-effects. As a result more effective curative therapies have been sought, including the use of cell based therapies to replace the lost dopaminergic neurons. In this review I am going to discuss PD and its possible repair using neural transplants. In particular I am going to discuss which type of cells are best considered as a reparative therapy, where they should be transplanted in the brain, when in the disease course and in which type of patient. By considering these issues, I hope to be able to make some recommendations as to the future use of this approach in PD. (shrink)

We will examine Kepler's use of a relation between velocity and distance from a centre of circular motion. This relation plays an essential role, through a derivation in chapter 40 of the Astronomia Nova, in the presentation of the Area Law of planetary motion. Kepler transcends ancient and contemporary applications of the distance-velocity relation by connecting it with his metaphysical commitment to the causal role of the Sun. His second main innovation is to replace the astronomical models of his predecessors (...) with an account that derives trajectories from physical principles. In this paper we restrict our attention primarily to the first 40 chapters of Kepler's Astronomia Nova. Hence, we do not discuss Kepler's discovery of elliptical planetary orbits. (shrink)