Dr Sydney Brenner has played a major, and unique, role in biology during the past 40 years. His contributions have ranged from key work on the structure of the genetic code and the existence of mRNA through the development of Caenorhabditis elegans as a key model system in developmental biology to genomic analysis and function in vertebrates. BioEssays went to interview Dr Brenner at his home in the cathedral city of Ely, England, on the significance of the (...) genome projects for human biology, in particular, and for biology, in general. (shrink)

The following text is an edited version of a recent interview with Sydney Brenner who has been at the forefront of many developments in molecular biology since the 1950s. It provides a participant’s view on current issues in the history and epistemology of molecular biology. The main issue raised by Brenner regards the relation of molecular biology to the new field of systems biology. Brenner defends the original programme of molecular biology—the molecular explanation of living processes—that (...) in his view has yet to be completed. The programme of systems biology in contrast he views as either trivial or as not achievable since it purports to deal with inverse problems that are impossible to solve in complex living systems. Other issues covered in the conversation concern the impact of the human genome sequencing project, the commercial turn in molecular biology and the contested disciplinary status of the science. (shrink)

Leading expressivist proposals characterize the mental state expressed in the making of a normative judgment solely in terms of intrinsic, psychological dispositions. As a result, they fail to capture a subset of the normative judgments that agents can and do make; they miss the way that external factors can influence what the making of a normative judgment looks like. This problem can be seen most plainly in the context of systemic oppression. Intuitively, one can make a normative judgment that conflicts (...) with the oppressive ideas one has previously been conditioned to endorse, but expressivism seems to deny that this is possible. The expressivist's inability to count these avowals made under oppression as genuine normative judgments makes expressivism deficient as a metaethical theory. (shrink)

Excerpt from Studies in Philosophical Criticism and Construction In the following pages my aim is to illustrate the principles of philosophic method by endeavouring critically to establish certain fundamental principles or Grundbegriffe in the spheres of Psychology, Logic and Epistemology, Ethics and Metaphysics; in other words, to lay the foundation for a more complete structure in each of these three branches of Philosophy. This double aim, however much it complicates the inquiry, is inevitable. A general discussion of philosophical method in (...) abstracto, without concurrently developing a general philosophical position, would seem to me to be futile even if it were possible. This is true of all branches of knowledge - true of the physical sciences as much as of any others. Generalisations as to scientific method - that is, as to the intellectual processes by which actual scientific results ought to be obtained - must assuredly be of very little value unless drawn in close connexion with concrete scientific work. But nowhere is the connexion more close than in Philosophy. Here, we cannot formulate our problems unless we are prepared with at least partial solutions. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

We analyze two problems in mathematics – the first (stated in our title) is extracted from Wittgenstein’s “Philosophy for Mathematicians”; the second (“What set of numbers is non-denumerable?”) is taken from Cantor. We then consider, by way of comparison, a problem in musical aesthetics concerning a Brahms variation on a theme by Haydn. Our aim is to bring out and elucidate the essentially riddle-like character of these problems.

In “The logic of deep disagreements” (Informal Logic, 1985), Robert Fogelin claimed that there is a kind of disagreement – deep disagreement – which is, by its very nature, impervious to rational resolution. He further claimed that these two views are attributable to Wittgenstein. Following an exposition and discussion of that claim, we review and draw some lessons from existing responses in the literature to Fogelin’s claims. In the final two sections (6 and 7) we explore the role reason can, (...) and sometimes does, play in the resolution of deep disagreements. In doing this we discuss a series of cases, mainly drawn from Wittgenstein, which we take to illustrate the resolution of deep disagreements through the use of what we call “rational persuasion.” We conclude that, while the role of argumentation in “normal” versus “deep” disagreements is characteristically different, it plays a crucial role in the resolution of both. (shrink)

Despite an intractable judiciary, there is widespread consensus within the legal academy that jury nullification is compatible with the rule of law. This proposition is most strongly tested by where a jury nullifies simply because it disagrees with the law itself. While some substantive nullifications can comport with the rule of law, most commentatorsjustice,vely undifferentiated view of a morality (even though jurisdictional and vicinage morality can diverge). In doing so, a healthy vision of antityrannical nullifications is presented, but this leaves (...) out many problematic cases. Once these errors are rectified, a more nuanced picture emerges, and it becomes apparent that localism will often disrupt the congruence feature of the rule of law. (shrink)

While democracy is derided for a variety of reasons in Plato’s thought, his most damning critique of that regime type does not involve an observation about democracy qua democracy, but of the transition that it so easily engenders: the decline to tyranny. Regimes are composed of individuals and groups, though, and Plato is anxious to ascribe culpability for the degradation. Two actors are the primary focus of his analysis — the political leaders and the demos. At times he emphasizes the (...) puissance of the demos, but in other passages he suggests it is the leaders who are most authoritative. This paper discusses these apparently contradictory passages, and works towards a reconciliation. It argues that neither is assigned sole culpability, as both work in complex synrgy, and that the underlying cause of the decline—and the motivator behind both actors — is not simply freedom, but greed for material wealth. (shrink)

Many say that ontological disputes are defective because they are unimportant or without substance. In this paper, we defend ontological disputes from the charge, with a special focus on disputes over the existence of composite objects. Disputes over the existence of composite objects, we argue, have a number of substantive implications across a variety of topics in metaphysics, science, philosophical theology, philosophy of mind, and ethics. Since the disputes over the existence of composite objects have these substantive implications, they are (...) themselves substantive. (shrink)

Background Diversity in Institutional Review Board (IRB) membership is important for both intrinsic and instrumental reasons, including fairness, promoting trust, improving decision quality, and responding to systemic racism. Yet U.S. IRBs remain racially and ethnically homogeneous, even as gender diversity has improved. Little is known about IRB chairpersons’ perspectives on membership diversity and barriers to increasing it, as well as current institutional efforts to promote diversity, equity, and inclusion (DEI) within IRB membership.Methods We surveyed IRB chairpersons leading U.S. boards registered (...) with the Office for Human Research Protections. Here, we focus exclusively on responses from a subset of 388 chairpersons of IRBs at universities and academic medical centers (AMCs).Results Board chairs were predominantly white and evenly split between men and women. Only about half reported that their boards had at least one member who is Black or African American (51%), Asian (56%), or Hispanic (48%), with 85% of university/AMC boards comprised entirely (15%) or mostly (70%) of white members. Most IRB chairpersons (64%) reported satisfaction with the current diversity of their membership. Participants largely agreed that considering diversity in the selection of IRB members is important (91%), including to improve the quality of IRB deliberation (80%), with an emphasis on racial/ethnic (85%) and gender diversity (74%). Most participants (80%) reported some type of active DEI effort regarding board membership at their university/AMC and just over half (57%) expressed satisfaction with these efforts.Conclusions Our national survey found that although university/AMC IRB chairpersons report valuing diversity in board membership, it may be lacking in key areas. Going forward, it will be important to specify clear reasons for diversity in the IRB context, as well to establish targets for acceptable levels of board diversity and to match DEI efforts to those targets. (shrink)

Segue abaixo a tradução do alemão da seção dedicada ao cinismo presente nas Lições Sobre a História da Filosofia de Georg Wilhelm Friedrich Hegel (1770-1831). Na seção em questão, o filósofo alemão aborda não somente a história da escola cínica, mas também seus princípios, suas influências e a importância que esse movimento teve para o pensamento filosófico posterior – sobretudo para o estoicismo.

Despite the importance of Suárez’s defense of the freedom of the will at the threshold of early modern philosophy, his account has received scant recent attention. This paper aims partially to redress that neglect. Suárez’s position can be understood as a balancing act between desiring to attribute libertarian freedom to agents and desiring to maintain the will’s status as a rational appetite. Hence, he rejects an intellectualism that says that choices are necessitated by the intellect’s judgements (since he does not (...) think that the judgements themselves can be directly free), but affirms that only what is judged good can be chosen. (shrink)

Thanks to Barbeyrac, Pufendorf and others, there is a long-familiar picture of Grotius as offering a groundbreaking account of natural law. By now there is also a familiar observation that there is no agreement what makes Grotius’s account innovative. Sometimes this leads to skepticism about how innovative Grotius’s account of natural law really is. Some scholars suggest that Grotius’s account of natural law resembles Suárez’s account. But others continue to argue that Barbeyrac is right to see Grotius as breaking the (...) ice of previous philosophy and laying the groundwork for a distinctively modern moral philosophy. I plan to contribute to the debate by arguing that, properly understood, Grotius’s position is similar to Suárez’s on a range of fundamental questions, and, furthermore, that seeing Grotius as making a radical break with the past violates his own self-conception. 1. (shrink)

In Physical Realization, Sydney Shoemaker considers the question of how physicalism can be true: how can all facts about the world, including mental ones, be constituted by facts about the distribution in the world of physical properties? Physicalism requires that the mental properties of a person are 'realized in' the physical properties of that person, and that all instantiations of properties in macroscopic objects are realized in microphysical states of affairs. Shoemaker offers an account of both these sorts of (...) realization, one which allows the realized properties to be causally efficacious. He also explores the implications of this account for a wide range of metaphysical issues, including the nature of persistence through time, the problem of material constitution, the possibility of emergent properties, and the nature of phenomenal consciousness. (shrink)

[Sydney Shoemaker] A major objection to the view that the relation of persons to human animals is coincidence rather than identity is that on this view the human animal will share the coincident person's physical properties, and so should (contrary to the view) share its mental properties. But while the same physical predicates are true of the person and the human animal, the difference in the persistence conditions of these entities implies that there will be a difference in the (...) properties ascribed by these predicates, with the result that the physical properties that determine the person's mental states will belong to the person and not to the human animal. /// [Galen Strawson] What are the grounds of self-consciousness? I consider 29 proposals and reject 22, including a number of proposals that experience of body (or bodies) is necessary for self-consciousness. A popular strategy in debates of this sort is to argue that one cannot be said to have some concept C (e.g. the concept ONESELF, necessary for self-consciousness) unless one has a need or a use for C given the character of one's experience considered independently of the character that it has given that one possesses C. I suggest that such arguments are invalid. (shrink)

Sydney Shoemaker is one of the most influential philosophers currently writing on philosophy of mind and metaphysics. The essays in this collection deal with the way in which we know our own minds, and with the nature of those mental states of which we have our most direct conscious awareness. Professor Shoemaker opposes the 'inner sense' conception of introspective self-knowledge. He defends the view that perceptual and sensory states have non-representational features - 'qualia' - that determine what it is (...) like to have them. Amongst the other topics covered are the unity of consciousness, and the idea that the 'first-person perspective' gives a privileged route to philosophical understanding of the nature of mind. This major collection is sure to prove invaluable to all advanced students of the philosophy of mind and cognitive science. (shrink)

Various theories of moral cognition posit that moral intuitions can be understood as the output of a computational process performed over structured mental representations of human action. We propose that action plan diagrams—“act trees”—can be a useful tool for theorists to succinctly and clearly present their hypotheses about the information contained in these representations. We then develop a methodology for using a series of linguistic probes to test the theories embodied in the act trees. In Study 1, we validate the (...) method by testing a specific hypothesis (diagrammed by act trees) about how subjects are representing two classic moral dilemmas and finding that the data support the hypothesis. In Studies 2–4, we explore possible explanations for discrete and surprising findings that our hypothesis did not predict. In Study 5, we apply the method to a less well‐studied case and show how new experiments generated by our method can be used to settle debates about how actions are mentally represented. In Study 6, we argue that our method captures the mental representation of human action better than an alternative approach. A brief conclusion suggests that act trees can be profitably used in various fields interested in complex representations of human action, including law, philosophy, psychology, linguistics, neuroscience, computer science, robotics, and artificial intelligence. (shrink)

[Sydney Shoemaker] A major objection to the view that the relation of persons to human animals is coincidence rather than identity is that on this view the human animal will share the coincident person's physical properties, and so should share its mental properties. But while the same physical predicates are true of the person and the human animal, the difference in the persistence conditions of these entities implies that there will be a difference in the properties ascribed by these (...) predicates, with the result that the physical properties that determine the person's mental states will belong to the person and not to the human animal. /// [Galen Strawson] What are the grounds of self-consciousness? I consider 29 proposals and reject 22, including a number of proposals that experience of body is necessary for self-consciousness. A popular strategy in debates of this sort is to argue that one cannot be said to have some concept C unless one has a need or a use for C given the character of one's experience considered independently of the character that it has given that one possesses C. I suggest that such arguments are invalid. (shrink)

A major objection to the view that the relation of persons to human animals is coincidence rather than identity is that on this view the human animal will share the coincident person's physical properties, and so should (contrary to the view) share its mental properties. But while the same physical predicates are true of the person and the human animal, the difference in the persistence conditions of these entities implies that there will be a difference in the properties ascribed by (...) these predicates, with the result that the physical properties that determine the person's mental states will belong to the person and not to the human animal. (shrink)

This anthology is the first devoted exclusively to On Certainty. The essays are grouped under four headings: the Framework, Transcendental, Epistemic and Therapeutic readings, and an introduction helps explain why these readings need not be seen as antagonistic. Contributions from W.H. Brenner, Alice Crary, Michael Kober, Edward Minar, Howard Mounce, Daniele Moyal-Sharrock, Thomas Morawetz, D.Z. Phillips, Duncan Pritchard, Rupert Read, Anthony Rudd, Joachim Schulte, Avrum Stroll, Michael Williams.

In “Animal Liberation and Environmental Ethics: Bad Marriage, Quick Divorce,” Mark Sagoff asserts that “environmentalists cannot be animal liberationists. Animal liberationists cannot be environmentalists”. In this article, I explore and refute this claim. As a result of structuring his argument around the work of Peter Singer and Aldo Leopold, I argue Sagoff too quickly dismisses rights-based approaches to animal liberation. Drawing on Thomas Pogge’s institutional framework for human rights, I present a rights-based foundation upon which animal liberationism and environmentalism can (...) be based compatibly. (shrink)

Adultcentrism is an inherent feature of the social fabrics comprising most resource-rich countries in the twenty-first century that undermines the capacities, value, and voices of young people in various ways. In the context of COVID-19, we are confronted with the question of whose voice matters and must ask: is adultcentrism ethically permissible during a pandemic? This Critical Controversy examines this question in relation to evolving concepts of childhood, children’s rights, and the capacities of young people, to highlight areas of tension, (...) future research, and potential for critical dialogue. (shrink)

What does it mean to say that this person at this time is 'the same' as that person at an earlier time? If the brain is damaged or the memory lost, how far does a person's identity continue? In this book two eminent philosophers develop very different approaches to the problem.

[Sydney Shoemaker] A major objection to the view that the relation of persons to human animals is coincidence rather than identity is that on this view the human animal will share the coincident person's physical properties, and so should (contrary to the view) share its mental properties. But while the same physical predicates are true of the person and the human animal, the difference in the persistence conditions of these entities implies that there will be a difference in the (...) properties ascribed by these predicates, with the result that the physical properties that determine the person's mental states will belong to the person and not to the human animal. /// [Galen Strawson] What are the grounds of self-consciousness? I consider 29 proposals and reject 22, including a number of proposals that experience of body (or bodies) is necessary for self-consciousness. A popular strategy in debates of this sort is to argue that one cannot be said to have some concept C (e.g. the concept ONESELF, necessary for self-consciousness) unless one has a need or a use for C given the character of one's experience considered independently of the character that it has given that one possesses C. I suggest that such arguments are invalid. (shrink)

Sellars’s critics sometimes contend that his proposed via media between Cartesian mentalism and logical behaviorism entials a correlative via media between a mentalist and a behaviorist analysis of meaning. They then argue that mentalism and behaviorism about meaning are exhaustive alternatives and any attempt to spell out a third semantic view fails. Hence, Sellars’s via media also fails. Sellars tries to avoid this line of argument by maintaining that meaning is not an analyzable concept, that is, it cannot be defined (...) in terms of mentalistic or behavioristic facts; nevertheless meaning can be explicated. Thus, no philosophy of mind will entail an analysis of meaning, although one can indeed be compatible with an explication of meaning and this is true of his “third way.” Commentators such as Chisholm and Young respond to this move by arguing that Sellars’s theory of meaning is successful only if it smuggles in a mentalist analysis of meaning and hence, Sellars’s revisionist semantics fail along with his revisionist philosophy of mind. (shrink)

Sellars’s critics sometimes contend that his proposed via media between Cartesian mentalism and logical behaviorism entials a correlative via media between a mentalist and a behaviorist analysis of meaning. They then argue that mentalism and behaviorism about meaning are exhaustive alternatives and any attempt to spell out a third semantic view fails. Hence, Sellars’s via media also fails. Sellars tries to avoid this line of argument by maintaining that meaning is not an analyzable concept, that is, it cannot be defined (...) in terms of mentalistic or behavioristic facts; nevertheless meaning can be explicated. Thus, no philosophy of mind will entail an analysis of meaning, although one can indeed be compatible with an explication of meaning and this is true of his “third way.” Commentators such as Chisholm and Young respond to this move by arguing that Sellars’s theory of meaning is successful only if it smuggles in a mentalist analysis of meaning and hence, Sellars’s revisionist semantics fail along with his revisionist philosophy of mind. (shrink)