Psychotherapy is commonly described as a “talking cure,” a treatment method that operates through linguistic action and interaction. The operative specifics of therapeutic language use, however, are insufficiently understood, mainly due to a multitude of disparate approaches that advance different notions of what “talking” means and what “cure” implies in the respective context. Accordingly, a clarification of the basic theoretical structure of “talking cure models,” i.e., models that describe therapeutic processes with a focus on language use, is a desideratum of (...) language-oriented psychotherapy research. Against this background the present paper suggests a theoretical framework of analysis which distinguishes four basic components of “talking cure models”: (1) a foundational theory (which suggests how linguistic activity can affect and transform human experience), (2) an experiential problem state (which defines the problem or pathology of the patient), (3) a curative linguistic activity (which defines linguistic activities that are supposed to effectuate a curative transformation of the experiential problem state), and (4) a change mechanism (which defines the processes and effects involved in such transformations). The purpose of the framework is to establish a terminological foundation that allows for systematically reconstructing basic properties and operative mechanisms of “talking cure models.” To demonstrate the applicability and utility of the framework, five distinct “talking cure models” which spell out the details of curative “talking” processes in terms of (1) catharsis, (2) symbolization, (3) narrative, (4) metaphor, and (5) neurocognitive inhibition are introduced and discussed in terms of the framework components. In summary, we hope that our framework will prove useful for the objective of clarifying the theoretical underpinnings of language-oriented psychotherapy research and help to establish a more comprehensive understanding of how curative language use contributes to the process of ther-apeutic change. (shrink)

New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

The last stand of the Greeks against Rome before Greece sank into the limbo of the Roman Empire is to some a truly patriotic rising, to others a misguided attempt at the impossible. Whatever their general estimation, most scholars have recognised social traits in the Achaian War and in the events which immediately preceded it.To Kahrstedt it was ‘bolschewistisches Fahrwasser … Massenmord der Besitzenden und Gebildeten … Ausrottung der Bourgeoisie … eine reine Proletarierrepublik, ein Kampf gegen die eigenen Bourgeois und (...) gegen die kapitalistische italische Grossmacht’. Colin sees in the events of 147/6 B.C. traits of ‘une révolution sociale’. According to Fustel de Coulanges, ‘ils abolissent les dettes, ou tout au moins en diffèrent le payement. Ils affranchissent et arment les esclaves.’ To Oertel, it was ‘sozialistische Bewegung … die Ziele sind die alten’. According to Pöhlmann, ‘selbst in die letzte grosse politische Krisis der Nation … spielt die sozialdemokratische Bewegung mächtig hinein’. In the view of Benecke ‘the masses in the Greek cities were encouraged by promises of a social revolution, and the … Achaean general Critolaus did not dare to disappoint them’. According to Rostovtzeff, the aim of Rome in the destruction of Corinth was ‘to put an end to social and economic revolution’. Other authorities, such as Niese, Mommsen, De Sanctis, Tarn, Niccolini, note social traits in their accounts of the events of 147/6 B.C. without attempting a general view of the place of the social factor in the Achaian War. (shrink)