New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

In this article we present a new kind of computing device that uses biochemical reactions networks as building blocks to implement logic gates. The architecture of a computing machine relies on these generic and composable building blocks, computation units, that can be used in multiple instances to perform complex boolean functions. Standard logical operations are implemented by biochemical networks, encapsulated and insulated within synthetic vesicles called protocells. These protocells are capable of exchanging energy and information with each other through transmembrane (...) electron transfer. In the paradigm of computation we propose, protoputing, a machine can solve only one problem and therefore has to be built specifically. Thus, the programming phase in the standard computing paradigm is represented in our approach by the set of assembly instructions that directs the wiring of the protocells that constitute the machine itself. To demonstrate the computing power of protocellular machines, we apply it to solve a NP-complete problem, known to be very demanding in computing power, the 3-SAT problem. We show how to program the assembly of a machine that can verify the satisfiability of a given boolean formula. Then we show how to use the massive parallelism of these machines to verify in less than 20 min all the valuations of the input variables and output a fluorescent signal when the formula is satisfiable or no signal at all otherwise. (shrink)

A small consortium of philosophers has begun work on the implications of epistemic networks (Zollman 2008 and forthcoming; Grim 2006, 2007; Weisberg and Muldoon forthcoming), building on theoretical work in economics, computer science, and engineering (Bala and Goyal 1998, Kleinberg 2001; Amaral et. al., 2004) and on some experimental work in social psychology (Mason, Jones, and Goldstone, 2008). This paper outlines core philosophical results and extends those results to the specific question of thresholds. Epistemic maximization of certain types does show (...) clear threshold effects. Intriguingly, however, those effects appear to be importantly independent from more familiar threshold effects in networks. (shrink)

Tens of thousands of students have learned to be more discerning at constructing and evaluating arguments with the help of Patrick J. Hurley. Hurley’s lucid, friendly, yet thorough presentation has made A CONCISE INTRODUCTION TO LOGIC the most widely used logic text in North America. In addition, the book’s accompanying technological resources, such as CengageNOW and Learning Logic, include interactive exercises as well as video and audio clips to reinforce what you read in the book and hear in class. (...) In short, you’ll have all the assistance you need to become a more logical thinker and communicator. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version. (shrink)

This paper investigates the effect of female representation on the board of directors on corporate response to stakeholders’ demands for increased public reporting about climate change-related risks. We rely on the Carbon Disclosure Project as a sustainability initiative supported by institutional investors. Greenhouse gas emissions measurement and its disclosure to investors can be thought of as a first step toward addressing climate change issues and reducing the firm’s carbon footprint. Based on a sample of publicly listed Canadian firms over the (...) period 2008–2014, we find that the likelihood of voluntary climate change disclosure increases with women percentage on boards. We also find evidence that supports critical mass theory with regard to board gender diversity. These findings reinforce initiatives being undertaken around the world to promote gender diversity in corporate governance while demonstrating board effectiveness in stakeholder management. (shrink)

At least since Aristotle’s famous 'sea-battle' passages in On Interpretation 9, some substantial minority of philosophers has been attracted to the doctrine of the open future--the doctrine that future contingent statements are not true. But, prima facie, such views seem inconsistent with the following intuition: if something has happened, then (looking back) it was the case that it would happen. How can it be that, looking forwards, it isn’t true that there will be a sea battle, while also being true (...) that, looking backwards, it was the case that there would be a sea battle? This tension forms, in large part, what might be called the problem of future contingents. A dominant trend in temporal logic and semantic theorizing about future contingents seeks to validate both intuitions. Theorists in this tradition--including some interpretations of Aristotle, but paradigmatically, Thomason (1970), as well as more recent developments in Belnap, et. al (2001) and MacFarlane (2003, 2014)--have argued that the apparent tension between the intuitions is in fact merely apparent. In short, such theorists seek to maintain both of the following two theses: (i) the open future: Future contingents are not true, and (ii) retro-closure: From the fact that something is true, it follows that it was the case that it would be true. It is well-known that reflection on the problem of future contingents has in many ways been inspired by importantly parallel issues regarding divine foreknowledge and indeterminism. In this paper, we take up this perspective, and ask what accepting both the open future and retro-closure predicts about omniscience. When we theorize about a perfect knower, we are theorizing about what an ideal agent ought to believe. Our contention is that there isn’t an acceptable view of ideally rational belief given the assumptions of the open future and retro-closure, and thus this casts doubt on the conjunction of those assumptions. (shrink)

It is widely accepted that there is what has been called a non-hypocrisy norm on the appropriateness of moral blame; roughly, one has standing to blame only if one is not guilty of the very offence one seeks to criticize. Our acceptance of this norm is embodied in the common retort to criticism, “Who are you to blame me?”. But there is a paradox lurking behind this commonplace norm. If it is always inappropriate for x to blame y for a (...) wrong that x has committed, then all cases in which x blames x (i.e. cases of self-blame) are rendered inappropriate. But it seems to be ethical common-sense that we are often, sadly, in position (indeed, excellent, privileged position) to blame ourselves for our own moral failings. And thus we have a paradox: a conflict between the inappropriateness of hypocritical blame, and the appropriateness of self-blame. We consider several ways of resolving the paradox, and contend none is as defensible as a position that simply accepts it: we should never blame ourselves. In defending this startling position, we defend a crucial distinction between self-blame and guilt. (shrink)

ABSTRACT Banks provide a valuable but inherently unstable combination of deposit‐taking and lending functions that were successfully held together for several decades after the New Deal by tough banking rules. The weakening of the rules after the 1970s promoted the displacement of traditional relationship‐based banking with securitized, arms‐length alternatives that encouraged banks to undertake activities about which bankers lacked deep relationship‐based knowledge of the risks. Ironically, this risky behavior, encouraged by loosened regulation, was reinforced by progressively tightened securities regulation, which (...) promoted stock‐market liquidity but also deprived large banks (and other publicly traded companies) of oversight by investors with “insiders’” knowledge. Both the underregulation of banking and the overregulation of securities were underpinned by economic theories that favored blind diversification in liquid, anonymous markets, and that ignored the value of relationship‐based knowledge and case‐by‐case due diligence. (shrink)

The epoch of Augustine is marked by several crises that settled in the Roman society. These crises did not escape from the sharp look of Saint Augustine. He showed how the political action of his contemporaries was something excessively ineffective to answer the wishes of a fair society, integrated by several people and races. This society, that had conquered in history, with mistakes and cleverness, power and glory, booth in the field of science and technology, for itself, the ways that (...) make sure to its citizens a prosper life, gradually succumbed. Thus, this article aims to exposes to the reader some aspects experienced by this society and make note that when policy is practiced by men who possess as premises the power and his own advantages, there is no richness or organization that will sustain such state or nation. (shrink)

Recently, the second author, Briseid, and Safarik introduced nonstandard Dialectica, a functional interpretation capable of eliminating instances of familiar principles of nonstandard arithmetic—including overspill, underspill, and generalizations to higher types—from proofs. We show that the properties of this interpretation are mirrored by first-order logic in a constructive sheaf model of nonstandard arithmetic due to Moerdijk, later developed by Palmgren, and draw some new connections between nonstandard principles and principles that are rejected by strict constructivism. Furthermore, we introduce a variant of (...) the Diller–Nahm interpretation with two different kinds of quantifiers, similar to Hernest’s light Dialectica interpretation, and show that one can obtain nonstandard Dialectica by weakening the computational content of the existential quantifiers—a process called herbrandization. We also define a constructive sheaf model mirroring this new functional interpretation, and show that the process of herbrandization has a clear meaning in terms of these sheaf models. (shrink)

The Polymath Project is an online collaborative enterprise that was initiated in 2009, when Timothy Gowers asked whether and how groups could work together to solve mathematical problems that “do not naturally split up into a vast number of subtasks.” Gowers proposed to answer this question himself by actually trying to set up such a collaboration, based on interactions taking place in the comment-threads of a series of posts on a WordPress blog. Hence, the first project officially started in early (...) 2009, to be proclaimed successful only 6 weeks later (Gowers and Nielsen 2009). From its inception until April 2018, 15 more Polymath problems (and a handful of smaller or related ones) have been launched. These projects have attracted attention from different scholarly communities, including the philosophy of mathematical practices, from the perspective of which the Polymath Project can be seen as a vast repository of mathematics in action. This chapter continues previous work by its authors on the topic in question and topics related. More specifically, for the purposes of this volume, it is our aim to both summarize and expand upon these earlier contributions. The starting point is the above observation that in the past decade, the issue of “massively collaborative mathematics” (to be qualified below) has drawn quite some attention. However, does it also warrant intensive philosophical attention in particular? For, as exciting as these developments might be from mathematical and other points of view, the enhanced possibilities that have come with it do not per se give rise to any philosophical import. In Van Bendegem (2011), one of us has indeed tentatively argued for the philosophical relevance of these new dynamics of proof construction flowing from the wide availability and efficiency of Internet technology. We shall below briefly rehearse and update the argument given there. (shrink)

This modern, advanced textbook reviews modal logic, a field which caught the attention of computer scientists in the late 1970's.

The text includes fragments of his work that have never before been translated.

Si le tragique n'est pas le propre de la tragédie grecque mais bien celui de 'l'être au monde de l'homme', sa conceptualisation n'advient qu'avec Wilderlin lorsque celui-ci s'approprie la question 'Comment lit-on la tragédie?', non plus selon son acception poétique, mais en tant que forme philosophique. Et si l'on suit sa réflexion, à la question 'Qu'est-ce que le tragique?', on notera qu'il est une façon d'être au monde de manière spéculative. L'union des contraires, de la poésie et de la sagesse, (...) voilà ce qui a tant plu à Empédocle, Hölderlin et Nietzsche. Si Je est un autre, la pensée tragique représente l'individu conscient de lui-même dans sa totalité. Mais, un personnage tragique n'est-il pas destiné à exister dans l'Histoire? Pour ces trois poètes, il s'agissait de traduire le monde du symbole, de la parabole, ou de l'allégorie en une nouvelle langue. En relisant de cette manière le tragique du monde, se découvre un sens qu'Empédocle, Hölderlin ou Nietzsche illuminèrent de leur regard: la mort dans les esquisses d'une tragédie pour Hölderlin et Nietzsche, ou la chute du démon chez Empédocle, traduisent la relation des oppositions dans l'absolu de la disparition"--Page 4 of cover. (shrink)

Management and Morality provides a comprehensive and accessible overview of the moral and ethical dimension to organizational and individual behavior, while adding an original, developmental perceptive. Management and Morality combines organizational theory and behavior with approaches to organizational and individual development. The first two sections of the book, Ethical Thinking and Management Practice, and Moral Issues in Organizations, provide a clear and thorough coverage of these areas relevant to ethical behavior in and of organizations. On this basis, the third section, (...) A Developmental Perspective, develops a new approach to ethical development of organizations and individuals concerned with the improvement of organizational structures, processes, and practices so as to allow for individual morality and individual moral behavior. Rich in its coverage of the field and variety of ideas, Management and Morality will be essential reading to students and academics in management, business and organizational ethics, organizational behavior and development, and organizational sociology. (shrink)

Contributed articles with reference to India.

Multidimensional practical demand has made Islamology one of the most "trendy" branches of Oriental studies and has created a host of serious difficulties and problems associated with an adequate scientific response to the "Islamic challenge". Excessive politicization of the study of such a phenomenon as Islamic fundamentalism, radicalism in the world, undoubtedly, undermines the true scientific knowledge, preventing the specialists from understanding this complex phenomenon.

BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

Le SMSI a affiché et promu une démarche de multipartenariat entre gouvernements, monde économique et société civile. Nous avons étudié la liste de diffusion électronique de l'un des caucus, « Civil Society - Internet Governance », au long d'une période clé de l'initiative onusienne. En analysant les modalités des échanges, nous nous sommes demandé quels types de tactiques et de stratégies émergent de ce dispositif, et dans quelle mesure il participe du débat public. Enfin, nous nous sommes interrogés sur les (...) limites du rôle effectif de la « société civile » dans un contexte international particulier.WSIS posted and promoted a multi-stakeholder approach between governments, civil society and business world. We studied the electronic mailing list of one of the caucus, "Civil Society - Internet Governance" during a key period of the UN initiative. By analyzing the terms of trade, we asked what kind of tactics and strategies emerge from this device, and how it participates in the public debate. Finally, we asked about the limits of the actual role of "civil society" in a particular international context. (shrink)

This article seeks to explore the theoretical contributions of Axel Honneth, particularly in his works, The Struggle for Recognition and Reification, aiming at diving deep into the debate on the contemporary ideological expressions and their incidence in the process of subjective constitution in teenage years. This particular interest springs from the need to interweave the concepts of reification, forgetfulness and recognition within a fruitful theoretical field in order to interpret a project work called Hip-Hop: cultures and identities, developed with teenagers (...) in a public school in the city of São Paulo, Brazil. From our point of view, the concepts of reification and forgetfulness are fundamental to identify how the conservative ideological expressions are present in the imaginary of adolescents in the contemporary world. Although rereading the concepts of reification and forgetfulness, as proposed by the author, is regarded as essential for understanding the ideological expressions that are based on and guided by consumption. However, even though we acknowledge Honneth's efforts toward moving forward with the concept of reification, it is crucial to emphasize the mediation concept Lukács explored in his work, History and Class Consciousness, so as to elucidate how the forgetfulness of the primary recognition relations is processed. (shrink)

This paper offers a new approach to an old debate about superaddition in Locke. Did Locke claim that some objects have powers that are unrelated to their natures or real essences? The question has split commentators. Some (Wilson, Stuart, Langton) claim the answer is yes and others (Ayers, Downing, Ott) claim the answer is no. This paper argues that both of these positions may be mistaken. I show that Locke embraced a robust epistemic humility. This epistemic humility includes ignorance of (...) the real essences of bodies, of the causal processes underlying the production of natural phenomena, and of God’s method of creation. I show how this epistemic humility offers strong support for an agnostic response to the question of superaddition. Locke did not intend to claim that bodies either do or do not have properties unrelated to their real essences. Instead, his primary goal in discussing the topic was to emphasize the strict limits to human knowledge. (shrink)

Les auteurs, à partir de rencontres entre historiens et spécialistes de littérature ou de cinéma, se penchent sur la récurrence du thème de la défaite. Vercingétorix, Jeanne d'Arc, Waterloo, Sedan, juin 1940 : la France exalte volontiers vaincus et pertes. La défaite permet de refonder une nation, un peuple, une communauté, elle est l'occasion d'un sursaut.

In this ground-breaking new text, Patrick Baert analyses the central perspectives in the philosophy of social science, critically investigating the work of Durkheim, Weber, Popper, critical realism, critical theory, and Rorty's neo pragmatism. Places key writers in their social and political contexts, helping to make their ideas meaningful to students. Shows how these authors’ views have practical uses in empirical research. Lively approach that makes complex ideas understandable to upper-level students, as well as having scholarly appeal.

The Handbook of Modal Logic contains 20 articles, which collectively introduce contemporary modal logic, survey current research, and indicate the way in which the field is developing. The articles survey the field from a wide variety of perspectives: the underling theory is explored in depth, modern computational approaches are treated, and six major applications areas of modal logic (in Mathematics, Computer Science, Artificial Intelligence, Linguistics, Game Theory, and Philosophy) are surveyed. The book contains both well-written expository articles, suitable for beginners (...) approaching the subject for the first time, and advanced articles, which will help those already familiar with the field to deepen their expertise. Please visit: http://people.uleth.ca/~woods/RedSeriesPromo_WP/PubSLPR.html - Compact modal logic reference - Computational approaches fully discussed - Contemporary applications of modal logic covered in depth. (shrink)

O trabalho pretende, a partir da publicação das “Confissões da Carne”, analisar o impasse que diz respeito a sua não publicação em vida por Foucault, em especial em função da entrada do sujeito como terceiro componente do triângulo arqueológico-genealógico, impondo uma reviravolta decisiva em sua pesquisa. A força aletúrgica do sujeito implica uma definitiva dessoberanização do dispositivo de poder. Por um lado, se a forma moderna prevê a sua transferência de um poder sobre si próprio aos outros, o complexo de (...) estratégias governamentais, que «orientam» a direção da consciência, não implica a abdicação da liberdade por parte da pessoa a qual foi dirigida; por outro, uma segunda operação surge da diferenciação específica entre o modelo antigo e o modelo cristão, quer dizer, se o antigo modelo de direção funciona com vistas à autonomização do sujeito, aquele exame de consciência cristão estabelece como eixo a dependência e desenvolve uma racionalidade pastoral. Assim Foucault chega a uma estética da existência que é puro exercício de liberdade e perfeita atitude, que se oferece aos outros como prova do seu próprio valor. É com isso que o volume quarto da história da sexualidade é confrontado. O que muda drasticamente na experiência cristã da carne é a relação do sujeito com a verdade. A confissão, mais do que expiação dos pecados, neste quadro intervém como atestado e como testemunho de si próprio. Em conclusão, para Foucault, conotado pela imperfeição que o domina, o sujeito cristão liga-se a uma interminável direção de consciência cujo preço é uma perda de identidade indefinida. Assim, a partir deste recorte, o problema que passa a enfrentar é como encontrar uma forma de fundamentar a hermenêutica de si, não no sacrifício, mas numa “emergência positiva”, teórica e prática, de si, expondo tanto o momento transicional das “Confissões da Carne” quanto a própria razão pela qual renuncia à sua publicação. (shrink)

Soren Kierkegaard, one of the most original thinkers of the nineteenth century, wrote widely on religious, psychological, and literary themes. This book shows how Kierkegaard developed his views in emphatic opposition to prevailing opinions. His arresting but paradoxical conception of religious belief is critically discussed, and Patrick Gardiner concludes this lucid introduction by showing how Kiekegaard has influenced contemporary thought.

Descartes with his sharp separation of the mental and the physical set the stage for the philosophy of mind for the next 350 years. Philosopher Patrick T. Mackenzie finds in the later writings of Wittgenstein the suggestion that Descartes got off on the wrong foot. Following Wittgenstein's lead, Mackenzie argues that instead of analyzing our human nature as a composite of mind and body, we should view ourselves as whole persons. One of the dividends of this approach to the (...) mind-body problem is that it provides us with a resolution to the problem of human freedom—i.e., how can a human being be free if his or her body (including the brain) belongs to a deterministic world? Mackenzie here argues that the person is largely free even though the movements of the body are determined by neurophysiological events. He takes the same approach to the philosophy of mind as that taken by M.R.Bennett and P.M.S.Hacker in their recent and controversial book, The Philosophical Foundations of Neuroscience. Mackenzie's approach is, however, much more accessible. Students of philosophy and philosophers interested in the problem of human freedom will welcome Mackenzie's fresh approach, especially those disenchanted by the present list of mind-body "isms.". (shrink)

Locke famously claimed that morality was capable of demonstration. But he also refused to provide a system of demonstrative morality. This paper addresses the mismatch between Locke’s stated views and his actual philosophical practice. While Locke’s claims about demonstrative morality have received a lot of attention it is rare to see them discussed in the context of his general theory of demonstration and his specific discussions of particular demonstrations. This paper explores Locke’s general remarks about demonstration as well as his (...) claims about demonstration in natural philosophy, mathematics, and morality. Careful attention to these detailed discussions motivates a reevaluation of Locke’s views on demonstrative knowledge of morality. Specifically, while Locke did believe that some demonstrative moral knowledge might be in-principle available to us he also believed that facts about the difficulty of demonstration meant that this knowledge would in-practice be largely unattainable. (shrink)

Why do humans make music? Theories of the evolution of musicality have focused mainly on the value of music for specific adaptive contexts such as mate selection, parental care, coalition signaling, and group cohesion. Synthesizing and extending previous proposals, we argue that social bonding is an overarching function that unifies all of these theories, and that musicality enabled social bonding at larger scales than grooming and other bonding mechanisms available in ancestral primate societies. We combine cross-disciplinary evidence from archeology, anthropology, (...) biology, musicology, psychology, and neuroscience into a unified framework that accounts for the biological and cultural evolution of music. We argue that the evolution of musicality involves gene–culture coevolution, through which proto-musical behaviors that initially arose and spread as cultural inventions had feedback effects on biological evolution because of their impact on social bonding. We emphasize the deep links between production, perception, prediction, and social reward arising from repetition, synchronization, and harmonization of rhythms and pitches, and summarize empirical evidence for these links at the levels of brain networks, physiological mechanisms, and behaviors across cultures and across species. Finally, we address potential criticisms and make testable predictions for future research, including neurobiological bases of musicality and relationships between human music, language, animal song, and other domains. The music and social bonding hypothesis provides the most comprehensive theory to date of the biological and cultural evolution of music. (shrink)

For humans, Artificial Intelligence operates more like a Rorschach test, as it is expected that intelligent machines will reflect humans' cognitive and physical behaviours. The concept of intelligence, however, is often confused with consciousness, and it is believed that the progress of intelligent machines will eventually result in them becoming conscious in the future. Nevertheless, what is overlooked is how the exploration of Artificial Intelligence also pertains to the development of human consciousness. An excellent example of this can be seen (...) in the film Being John Malkovich (1999). In the film, different characters have their perceptions altered as a result of hacking into the mind of John Malkovich, which produces sensations that may have remained hidden to their consciousness due to their dis-abilities. This article engages with the research question: Can the symbiotic relationship between humans and machines trigger an artificial consciousness for humans? An artificially created consciousness is the premise that a machine can generate knowledge about an individual that is not already present in the person. For the same purpose, the article takes the cinematic text Being John Malkovich by Spike Jonze for exploring concepts such as human/robot rights, virtual sex, virtual rape, and bodily disability, which are essential topics in the midst of increasing human- Artificial Intelligence interaction. The purpose of this article is to contribute towards the creation of a better understanding of Artificial Intelligence, particularly from the perspective of film studies and philosophy, by highlighting the potential of Artificial Intelligence as a vessel for exploring human consciousness. (shrink)

This paper develops and refines the suggestion that logical systems are conceptual artefacts that are the outcome of a design-process by exploring how a constructionist epistemology and meta-philosophy can be integrated within the philosophy of logic.