In a recent Opinion article, Sui and Humphreys [1] argue that experimental findings suggest self is ‘special’, in that self-reference serves a binding function within human cognitive economy. Contrasting their view with other functionalist positions, chiefly Dennett's [2], they deny that self is a convenient fiction and adduce findings to show that a ‘core self representation’ serves as an ‘integrative glue’ helping to bind distinct types of information as well as distinct stages of psycho- logical processing. In other words, where (...) Dennett regards self as analogous to a center of gravity, a simplification posited by observers, Sui and Humphreys regard self as a function that modulates mental processes. In practice, however, the concept of ‘self’ they employ is not unlike Dennett's. We side with Sui and Humphreys in hold- ing that self-reference modulates mental processes: reference to self during a task can bind memory to source, increase perceptual integration, and link attention to decision making, among other things. What is more, these functions are not reducible to other factors such as semantic coding, familiarity, or reward [3]. But whereas Sui and Humphreys contribute important empirical detail, the binding functions they describe are compatible with Dennett's version of functionalism, which treats self as an artifact of social process. (shrink)

Review of Paul Pietroski, Causing Actions.

Most mental disorders affect only a small segment of the population. On the reasonable assumption that minds or brains are prone to occasional malfunction, these disorders do not seem to pose distinctive explanatory problems. Depression, however, because it is so prevalent and costly, poses a conundrum that some try to explain by characterizing it as an adaptation—a trait that exists because it performed fitness-enhancing functions in ancestral populations. Heretofore, proposed evolutionary explanations of depression did not focus on thought processes; instead, (...) they emphasized that it facilitates navigation of adverse social circumstances or promotes immune response to infectious agents. According to a new hypothesis, the “analytical rumination hypothesis” (ARH), however, depression’s crucial adaptive trait is rumination—negative, intrusive thought. ARH holds that, (i) social dilemmas trigger depressed mood; (ii) depressed mood induces changes in body systems that facilitate ruminative analysis aimed at solving dilemmas; and, (iii) depressive rumination is a fitness-enhancing trait that was selected for in evolutionary time. Jointly, (i)~(iii) imply that we should not think of rumination as a disorder; instead, it is a trade-off, an eminently rational one. In the same way that fever solves a problem—coordination of the immune system in response to infection—so too does depressive rumination solve a problem, a social dilemma, albeit at the cost of inducing anhedonia and other maladies. But they argue that the cost is worthwhile, something that should be endured “until the problem is solved.” First, we argue that there are two distinct types of rumination, brooding and pondering; the former is associated with a disposition for depression, not the latter. But only the latter has the problem-solving capabilities that ARH requires. Second, recent brain imaging studies of depression reveal resting state hypoactivity in lateral regions and hyperactivity in paralimbic regions; this asymmetric pattern correlates with heightened levels of brooding, self-focused rumination. In other words, on the personal level, patients are trapped within self, isolated from the external world and suffused with negative affect; on the subpersonal level, this pattern is reflected by an asymmetric pattern of lateral vs. paralimbic resting state activity. Third, we proceed to conjecture that rational responses (e.g., pondering) to social dilemmas are those that strike a balance between internal and external considerations in the process of belief formation. Fourth, because the asymmetric resting state activity blocks those who suffer with depression from accessing and processing potentially positive stimuli from the external world, the capacity for rational, analytic response—hence, problem-solving—is constrained. Fifth, it follows that, although there might be conditions for which suffering should be endured rather than pharmacologically alleviated, depression is not one of those. Indeed, in view of the effects of the asymmetric resting state pattern, it is unlikely that depressive rumination would have been useful even for ancestral populations. (shrink)

Time is an essential feature in bipolar disorder (BP). Manic and depressed BP patients perceive the speed of time as either too fast or too slow. The present article combines theoretical and empirical approaches to integrate phenomenological, psychological, and neuroscientific accounts of abnormal time perception in BP. Phenomenology distinguishes between perception of inner time, ie, self-time, and outer time, ie, world-time, that desynchronize or dissociate from each other in BP: inner time speed is abnormally slow (as in depression) or fast (...) (as in mania) and, by taking on the role as default-mode function, impacts and modulates the perception of outer time speed in an opposite way, ie, as too fast in depression and too slow in mania. Complementing, psychological investigation show opposite results in time perception, ie, time estimation and reproduction, in manic and depressed BP. Neuronally, time speed can be indexed by neuronal variability, ie, SD. Our own empirical data show opposite changes in manic and depressed BP (and major depressive disorder [MDD]) with abnormal SD balance, ie, SD ratio, between somatomotor and sensory networks that can be associated with inner and outer time. Taken together, our combined theoretical-empirical approach demonstrates that desynchronization or dissociation between inner and outer time in BP can be traced to opposite neuronal variability patterns in somatomotor and sensory networks. This opens the door for individualized therapeutic “normalization” of neuronal variability pattern in somatomotor and sensory networks by stimulation with TMS and/or tDCS. (shrink)

Social science, history, and philosophy have often been neglect in thinking through their fundamentally intertwined relationship. The result is often an inattention to philosophy where social science and history is concerned, or a neglect of historicity and social analysis where philosophy is concerned. Meanwhile, the place of values in research is often uneasily passed over in silence. The inattention to, and loss of, the intersection between these different disciplines and their subject matters, leaves our investigations all the more impoverished as (...) a result. In resolving these problems, it is not enough to strive for cooperation or integration, but to rethink of the nature of the disciplines themselves; their interests, purposes, and presuppositions. In this volume, contributors explore different facets of these relationships, and move beyond the problematics erected by positivism often cast in terms of value-free or value-neutral science, that is, a science obsessed with empirical data, schematic classifications, and the pursuit of law-like forms. While positivism has been subject to critique, the influence and legacy of positivism remains. It remains in the way in which we often think about science; the line drawn between the sciences and the humanities; the norms researchers should follow; what a successful explanation looks like; and the ethical, normative, and political implications of scientific research. Aimed at students and researchers of philosophy, history and the social sciences, this book is driven by a desire to revindicate questions concerning ontology and social ontology, to rethink the nature of explanation, and to resituate normativity and values within scientific, social scientific, and historical pursuits. (shrink)

The book includes contributions by Sarah-Jayne Blakemore, George F. R. Ellis, Christopher D. Frith, Mark Hallett, David Hodgson, Owen D. Jones, Alicia Juarrero, J. A. Scott Kelso, Christof Koch, Hans Küng, Hakwan C. Lau, Dean Mobbs,...

Recent studies have demonstrated neural overlap between resting state activity and self-referential processing. This “rest-self” overlap occurs especially in anterior cortical midline structures like the perigenual anterior cingulate cortex (PACC). However, the exact neurotemporal and biochemical mechanisms remain to be identified. Therefore, we conducted a combined electroencephalography (EEG)-magnetic resonance spectroscopy (MRS) study. EEG focused on pre-stimulus (e.g., prior to stimulus presentation or perception) power changes to assess the degree to which those changes can predict subjects’ perception (and judgment) of subsequent (...) stimuli as high or low self-related. MRS measured resting state concentration of glutamate, focusing on PACC. High pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power significantly correlated with both perception of stimuli judged to be highly self-related and with resting state glutamate concentrations in the PACC. In sum, our results show (i) pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power and resting state glutamate concentration to mediate rest-self overlap that (ii) dispose or incline subjects to assign high degrees of self-relatedness to perceptual stimuli. (shrink)

Objective: The dopamine hypothesis is one of the most influential theories of the neurobiological background of schizophrenia (SCZ). However, direct evidence for abnormal dopamine-related subcortical-cortical circuitry disconnectivity is still lacking. The aim of this study was therefore to test dopamine-related substantia nigra (SN)-based striato-thalamo-cortical resting-state functional connectivity (FC) in SCZ. Method: Based on our a priori hypothesis, we analyzed a large sample resting-state functional magnetic resonance imaging (fMRI) dataset from first-episode drug-naïve SCZ patients (n = 112) and healthy controls (n (...) = 82) using the SN as the seed region for an investigation of striato-thalamo-cortical FC. This was done in the standard band of slow frequency oscillations and then in its subfrequency bands (Slow4 and Slow5). Results: The analysis showed in SCZ: (1) reciprocal functional hypo-connectivity between SN and striatum, with differential patterns for Slow5 and Slow4; (2) functional hypo-connectivity between striatum and thalamus, as well as functional hyper-connectivity between thalamus and sensorimotor cortical areas, specifically in Slow4; (3) correlation of thalamo-sensorimotor functional hyper-connectivity with psychopathological symptoms. Conclusions: We demonstrate abnormal dopamine-related SN-based striato-thalamo-cortical FC in slow frequency oscillations in first-episode drug-naive SCZ. This suggests that altered dopaminergic function in the SN leads to abnormal neuronal synchronization (as indexed by FC) within subcortical-cortical circuitry, complementing the dopamine hypothesis in SCZ on the regional level of resting-state activity. (shrink)

Spontaneous activity levels prior to stimulus presentation can determine how that stimulus will be perceived. It has also been proposed that such spontaneous activity, particularly in the default-mode network (DMN), is involved in self-related processing. We therefore hypothesised that pre-stimulus activity levels in the DMN predict whether a stimulus is judged as self-related or not. Method: Participants were presented in the MRI scanner with a white noise stimulus that they were instructed contained their name or another. They then had to (...) respond with which name they thought they heard. Regions where there was an activity level difference between self and other response trials two seconds prior to the stimulus being presented were identified. Results: Pre-stimulus activity levels were higher in the right temporoparietal junction (RTPJ), the right temporal pole (RTP), and the left superior temporal gyrus in trials where the participant responded that they heard their own name than trials where they responded that they heard another. Conclusion: Pre-stimulus spontaneous activity levels in particular brain regions, largely overlapping with the DMN, predict the subsequent judgement of stimuli as self-related. This extends our current knowledge of self-related processing and its apparent relationship with intrinsic brain activity in what can be termed a rest-self overlap. (shrink)

Disorders of consciousness (DoC)—that is, unresponsive wakefulness syndrome/vegetative state and minimally conscious state—are debilitating conditions for which no reliable markers of consciousness recovery have yet been identified. Evidence points to the GABAergic system being altered in DoC, making it a potential target as such a marker.

One day, Matthew Eaton was walking through an impromptu animal shelter display at his local pet store when suddenly an eight-month-old kitten dug his claws into Eaton’s flesh. Eaton recognized that the “eyes of this cat and the curve of his claw” compelled a response analogous to those found in the writings of Buber, Levinas, and Derrida. And not just Eaton but a whole community of theologians have found themselves in an encounter with particular places and animals that demands rich (...) theological reflection. Eaton enlisted fellow editors Harvie and Bechtel to collect the essays in this volume, in which theologians listen to horses, rats, snakes, cats, dogs, and the earth itself, who become new theological voices demanding a response. In this volume, the voice of the more-than-human world is heard as making theology possible. These essays suggest that what we say theologically represents not simply ideas of our own making subsequently superimposed onto the natural world through our own discovery, but rather flow from an expressive Earth. With additional contributions from: Kimberly Carfore Lisa E. Dahill Celia Deane-Drummond Heather Eaton Nathan Kowalsky Abigail Lofte Jame Schaefer Cristina D. Vanin Mark Wallace Grace Y. Kao Chris Carter John Berkman Laura Hobgood. (shrink)

Flesh of My Flesh is a collection of articles by today's most respected scientists, philosophers, bioethicists, theologians, and law professors about whether we should allow human cloning. It includes historical pieces to provide background for the current debate. Religious, philosophical, and legal points of view are all represented.

The following assumptions are necessary to get the contemporary problem of mental causation off the ground.

This book celebrates the work of Patricia Werhane, an iconic figure in business ethics. This festschrift is a collection of articles that build on Werhane’s contributions to business ethics in such areas as Employee Rights, the Legacy of Adam Smith, Moral Imagination, Women in Business, the development of the field of business ethics, and her contributions to such fields as Health Care, Education, Teaching, and Philosophy. All papers are new contributions to the management literature written by well-known business ethicists, such (...) as Norman Bowie, Richard De George, Ronald Duska, Edwin Hartman, Michael Hoffman, Mollie Painter-Morland, Mark Schwartz, Andrew Wicks, and others. The volume is comprised of articles that reflect on Werhane’s work as well as build on it as a way to advance further research. At the end of the festschrift, Pat Werhane provides responses to each chapter. The first chapter of the book also includes the overview of Patricia Werhane’s work and her academic career. The book is written to appeal to management scholars and graduate students interested in the areas of Business Ethics, Modern Capitalism, and Human Rights. Patricia Werhane is one of the most distinguished figures in the field of business ethics. She was a founder of the field, she is one of its leading scholars, and she has had a profound impact on the world of business practice. Among her many accomplishments, Pat is known for her original work on moral imagination, she is an acclaimed authority on employee rights in the workplace, and she is one of the leading scholars on Adam Smith. Having been active in Academia for over 50 years, Werhane is a prolific author of over a hundred articles and book chapters, and the author or editor of twenty-seven books, including Adam Smith and his Legacy for Modern Capitalism, Moral Imagination and Management Decision-Making, and co-authored books Organization Ethics in Health Care, Alleviating Poverty Through Profitable Partnerships, Obstacles to Ethical Decision-Making, Corporate Responsibility: The American Experience, and Research Approaches to Business Ethics and Corporate Responsibility. (shrink)

The genes involved in methionine biosynthesis are scattered throughout the Escherichia coli chromosome and are controlled in a similar but not coordinated manner. The product of the metJ gene and S‐adenosylmethionine are involved in the repression of this ‘regulon’.

ExcerptI.The work of Georg Lukács has languished in critical neglect since a period of intense interest in his work in the 1960s and early 1970s. Lately, however, there are signs of a revival of interest. The reasons for this are multiple. On the one hand, art theorists and literary critics are turning to Lukács's concept of realism in order to help understand the political and realist turn of contemporary art and literary works.1 In a separate development, social and political theorists (...) are turning again to Lukács's concept of reification as a way of understanding the peculiar social pathologies of…. (shrink)

Although a number of commentators have remarked upon the simi larities between aspects of George Herbert Mead's social psychology and Adam Smith's Theory of Moral Sentiments, there has been no sys tematic attempt to document the connection. This article attempts to do precisely that. First, the legitimacy of the connection is established by showing the likelihood that Mead knew this particular work by Smith, and by bringing together the various treatments of the matter made by commentators. Since Mead himself (...) does not reference Smith's theory, however, the continuity can be demonstrated only on the level of ideas. Second, then, the movement of Mead's thought is recon structed through the terms 'individual' and 'social epistemology'. An account based upon the former posits self-consciousness as the pre condition for knowledge about others, while the latter makes the development of self dependent on a concept of community. Mead's div ision of the self into the 'I' and the 'me' is central in forcing the shift from the one to the other. Smith's account of moral action, it is then argued, rests upon the same logic. His ideas of 'changing roles in the fancy', the 'impartial spectator', and division of the self, parallel Mead's 'taking the role of the other' and discussion of the self. The 'ideal' spec tator corresponds to Mead's 'generalized other'. The article concludes by drawing a parallel between Mead and Smith on the universal facts of human nature and the moral community. (shrink)

The social psychologist George Herbert Mead and the cognitive linguist Noam Chomsky both investigated the nature of language and mind during the 20th century. They approached the issues broadly, pursuing both philosophical and scientific lines of reasoning and evidence. This comparative analysis of Mead and Chomsky identifies fourteen questions that summarize their collective effort, and which animated much of the debate concerning language and mind in the 20th century. These questions continue to be relevant to 21st century inquiries. This (...) paper identifies which questions have been resolved and which have not, and discusses each in the context of relevant literature. The net result is a set of questions that inform interdisciplinary-minded inquiries today into the nature of language and mind. (shrink)

The Human Genome Project is an expensive, ambitious, and controversial attempt to locate and map every one of the approximately 100,000 genes in the human body. If it works, and we are able, for instance, to identify markers for genetic diseases long before they develop, who will have the right to obtain such information? What will be the consequences for health care, health insurance, employability, and research priorities? And, more broadly, how will attitudes toward human differences be affected, morally and (...) socially, by the setting of a genetic “standard”? The compatibility of individual rights and genetic fairness is challenged by the technological possibilities of the future, making it difficult to create an agenda for a “just genetics.” Beginning with an account of the utopian dreams and authoritarian tendencies of historical eugenics movements, this book’s nine essays probe the potential social uses and abuses of detailed genetic information. Lucid and wide-ranging, these contributions will interest bioethicists, legal scholars, and policy makers. Essays: “The Genome Project and the Meaning of Difference,” Timothy F. Murphy “Eugenics and the Human Genome Project: Is the Past Prologue?,” Daniel J. Kevles “Handle with Care: Race, Class, and Genetics,” Arthur L. Caplan “Public Choices and Private Choices: Legal Regulation of Genetic Testing,” Lori B. Andrews “Rules for Gene Banks: Protecting Privacy in the Genetics Age,” George J. Annas “Use of Genetic Information by Private Insurers,” Robert J. Pokorski “The Genome Project, Individual Differences, and Just Health Care,” Norman Daniels “Just Genetics: A Problem Agenda,” Leonard M. Fleck “Justice and the Limitations of Genetic Knowledge,” Marc A. Lappé. (shrink)

The group of Dialectical Theology (also known as Neo-Orthodoxy) included some of the most well-known theologians of the 20th century – Karl Barth, Rudolf Bultmann, Friedrich Gogarten, Eduard Thurneysen, Georg Merz und Emil Brunner. In the summer of 1922 they founded the journal Zwischen den Zeiten, which launched Dialectical Theology as the most influential avant-garde movement in Protestantism during the Weimar Republic. Due to internal strife and theological disagreements, the group began to lose strength in the early 1930s and eventually (...) split up and ceased publishing Zwischen den Zeiten in 1933. The individual members later became fierce critics of each other’s theological works. Gogarten and Barth became arch enemies during the so-called “church struggle” (Kirchenkampf), and Bultmann and Barth became each other’s nemesis in the Federal Republic of Germany.In this article I examine the rise and fall of this movement. I argue that the concept “generation” was central to the early self-understanding and selfjustification of the group. It allowed the group to forge an alliance and oppose an antagonistic group of influential theologians. The claim to speak up for a young generation of theologians and pastors – in opposition to an older, liberal generation – became the rallying cry for Dialectical Theology. Further, I argue that conferences, not only the theological writings, played a central, constitutive role in establishing the group as a theological movement. It was at conferences that the members of Dialectical Theology could challenge the older generation and assert their own theological stance. Instead of merely concentrating on the published theological writings of each of the members, I thus argue that one must additionally focus on the applied concepts and the role of conferences to understand the history of Dialectical Theology. It is only when we include these additional contexts that we understand how Dialectical Theology was able to be launched and sustained as a theological movement despite the irreconcilable differences amongst the members. (shrink)

This volume brings together a diverse range of perspectives reflecting the international appeal and multi-disciplinary interest that Oakeshott now attracts. The essays offer a variety of approaches to Oakeshott’s thought — testament to the abiding depth, originality, suggestiveness and complexity of his writings. The essays include contributions from well-known Oakeshott scholars along with ample representation from a new generation. As a collection these essays challenge Oakeshott’s reputation as merely a ‘critic of social planning’.Contributors include Josiah Lee Auspitz, Debra Candreva, Wendell (...) John Coats Jr., Douglas DenUyl, George Feaver, Paul Franco, Richard Friedman, Timothy Fuller, Robert Grant, Eric S. Kos, Leslie Marsh, Kenneth Minogue, Terry Nardin, Keith Sutherland, Martyn Thompson and Gerhard Wolmarans. (shrink)

Is the Dionysian God, or an experience of the Dionysian God, absolutely ineffable? Does the Dionysian corpus assert or perform such ineffability? This paper will argue that the answer to each of these questions is no. The Dionysian God is known hyper-nous as the hyper-ousia cause of all. And the Dionysian corpus unambiguously refers to, asserts of, and metaphorizes about this God just so. In arguing these points, this paper will call upon both the speech act theory of John Searle (...) and the metaphor theory of George Lakoff and Mark Johnson. More particularly, it will look to Searle’s rules of reference and predication and conditions of illocutionary acts, as well as Lakoff and Johnson’s schematization of metaphor gestalt and entailment to show how Dionysian expressions of inexpressibility are rule-governed and the Dionysian God is thereby effable. (shrink)

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

The Politics of Method in the Human Sciences provides a remarkable comparative assessment of the variations of positivism and alternative epistemologies in the contemporary human sciences. Often declared obsolete, positivism is alive and well in a number of the fields; in others, its influence is significantly diminished. The essays in this collection investigate its mutations in form and degree across the social science disciplines. Looking at methodological assumptions field by field, individual essays address anthropology, area studies, economics, history, the philosophy (...) of science, political science and political theory, and sociology. Essayists trace disciplinary developments through the long twentieth century, focusing on the decades since World War II. Contributors explore and contrast some of the major alternatives to positivist epistemologies, including Marxism, psychoanalysis, poststructuralism, narrative theory, and actor-network theory. Almost all the essays are written by well-known practitioners of the fields discussed. Some essayists approach positivism and anti-positivism via close readings of texts influential in their respective disciplines. Some engage in ethnographies of the present-day human sciences; others are more historical in method. All of them critique contemporary social scientific practice. Together, they trace a trajectory of thought and method running from the past through the present and pointing toward possible futures. Contributors. Andrew Abbott, Daniel Breslau, Michael Burawoy, Andrew Collier , Michael Dutton, Geoff Eley, Anthony Elliott, Stephen Engelmann, Sandra Harding, Emily Hauptmann, Webb Keane, Tony Lawson, Sophia Mihic, Philip Mirowski, Timothy Mitchell, William H. Sewell Jr., Margaret R. Somers, George Steinmetz, Elizabeth Wingrove. (shrink)

According to the biopsychosocial model, developed by the late Dr. George Engel, how physicians approach patients and the problems they present is very much ...

This volume succeeds the same authors' well-known An Introduction to Modal Logic and A Companion to Modal Logic. We designate the three books and their authors NIML, IML, CML and H&C respectively. Sadly, George Hughes died partway through the writing of NIML.

Without so much as an America Online account, Timothy Dwight, president of Yale University two centuries ago, learned of an evil plot -- hatched in France by Freemasons hopped up on Enlightenment philosophy -- to overthrow the United States Government. A Bavarian secret society called the Order of the Illuminati was also involved. Unable to access alt.conspiracy or even a good E-mail program, Dwight had to resort to public speaking to spread the word.

In 1914, on the eve of the Great War, the eminent scholar and polymath, Theodore Merz, published what would be the final volume of his magisterial history of nineteenth-century European thought. A belated review of this volume appeared in the April 1918 issue of the American Historical Review. This particular review, though favorable, was inexplicably unsigned. Our paper offers compelling evidence that the author of this unsigned review was George H. Mead, the pragmatist philosopher from the University of Chicago. (...) The paper is organized in the following fashion. First, several types of documentary evidence are cited in support of the claim that Mead authored the unsigned review. Second, content analysis is used to identify themes in the review that reflect the distinctive intellectual concerns of Mead. One such concern was the ability of research-based science to address and rectify problematic aspects of social life. The concluding section of the paper reprints in its entirety Mead’s 1918 review. (shrink)

Russell once compared a good notation to a good teacher. Whatever can be said in a good notation can be said in a bad one, just as whatever can be said by a good teacher can be said by a bad one; the difference is that the good notation and the good teacher help one discover more for oneself. It has gradually emerged that the language of modal logic constitutes a good notation for the study of formal provability. That application (...) of modal logic is the subject of George Boolos' welcome new book. (shrink)

In epistemology and in philosophy of language there is fierce debate about the role of context in knowledge, understanding, and meaning. Many contemporary epistemologists take seriously the thesis that epistemic vocabulary is context-sensitive. This thesis is of course a semantic claim, so it has brought epistemologists into contact with work on context in semantics by philosophers of language. This volume brings together the debates, in a set of twelve specially written essays representing the latest work by leading figures in the (...) two fields. All future work on contextualism will start here. Contributors: Kent Bach, Herman Cappelen, Andy Egan, Michael Glanzberg, John Hawthorne, Ernest Lepore, Peter Ludlow, Peter Pagin, Georg Peter, Paul M. Pietroski, Gerhard Preyer, Jonathan Schaffer, Jason Stanley, Brian Weatherson, Timothy Williamson. (shrink)

Russell once compared a good notation to a good teacher. Whatever can be said in a good notation can be said in a bad one, just as whatever can be said by a good teacher can be said by a bad one; the difference is that the good notation and the good teacher help one discover more for oneself. It has gradually emerged that the language of modal logic constitutes a good notation for the study of formal provability. That application (...) of modal logic is the subject of George Boolos' welcome new book. (shrink)