Antimicrobial resistance (AMR) is an urgent threat to global public health and development. Mitigating this threat requires substantial short-term action on key AMR priorities. While international legal agreements are the strongest mechanism for ensuring collaboration among countries, negotiating new international agreements can be a slow process. In the second article in this special issue, we consider whether harnessing existing international legal agreements offers an opportunity to increase collective action on AMR goals in the short-term. We highlight ten AMR priorities and (...) several strategies for achieving these goals using existing “legal hooks” that draw on elements of international environmental, trade and health laws governing related matters that could be used as they exist or revised to include AMR. We also consider the institutional mandates of international authorities to highlight areas where additional steps could be taken on AMR without constitutional changes. Overall, we identify 37 possible mechanisms to strengthen AMR governance using the International Health Regulations, the Agreement on the Application of Sanitary and Phytosanitary Measures, the Agreement on Trade-Related Aspects of Intellectual Property Rights, the Agreement on Technical Barriers to Trade, the International Convention on the Harmonized Commodity Description and Coding System, and the Basel, Rotterdam, and Stockholm conventions. Although we identify many shorter-term opportunities for addressing AMR using existing legal hooks, none of these options are capable of comprehensively addressing all global governance challenges related to AMR, such that they should be pursued simultaneously with longer-term approaches including a dedicated international legal agreement on AMR. (shrink)

To address the complex challenge of global antimicrobial resistance (AMR), a pandemic treaty should include mechanisms that 1) equitably address the access gap for antimicrobials, diagnostic technologies, and alternative therapies; 2) equitably conserve antimicrobials to sustain effectiveness and access across time and space; 3) equitably finance the investment, discovery, development, and distribution of new technologies; and 4) equitably finance and establish greater upstream and midstream infection prevention measures globally. Biodiversity, climate, and nuclear governance offer lessons for addressing these challenges.

Global antimicrobial resistance (AMR) is currently governed by a decentralized regime complex composed of multiple institutions with overlapping and sometimes conflicting principles, norms, rules, and procedures. Such a decentralized regime complex provides certain advantages and disadvantages when compared to a centralized regime. A pandemic instrument can optimize the regime complex for AMR by leveraging the strengths of both centralization and decentralization. Existing climate treaties under the UNFCCC offer lessons for achieving this hybrid approach.

An international legal agreement governing the global antimicrobial commons would represent the strongest commitment mechanism for achieving collective action on antimicrobial resistance (AMR). Since AMR has important similarities to climate change—both are common pool resource challenges that require massive, long-term political commitments—the first article in this special issue draws lessons from various climate agreements that could be applicable for developing a grand bargain on AMR. We consider the similarities and differences between the Paris Climate Agreement and current governance structures for (...) AMR, and identify the merits and challenges associated with different international forums for developing a long-term international agreement on AMR. To be effective, fair, and feasible, an enduring legal agreement on AMR will require a combination of universal, differentiated, and individualized requirements, nationally determined contributions that are regularly reviewed and ratcheted up in level of ambition, a regular independent scientific stocktake to support evidence informed policymaking, and a concrete global goal to rally support. (shrink)

Antimicrobial resistance is one of the greatest public health crises of our time. The natural biological process that causes microbes to become resistant to antimicrobial drugs presents a complex social challenge requiring more effective and sustainable management of the global antimicrobial commons—the common pool of effective antimicrobials. This special issue of Health Care Analysis explores the potential of two legal approaches—one long-term and one short-term—for managing the antimicrobial commons. The first article explores the lessons for antimicrobial resistance that can be (...) learned from recent climate change agreements, and the second article explores how existing international laws can be adapted to better support global action in the short-term. (shrink)

Ensuring that life-saving antimicrobials remain available as effective treatment options in the face of rapidly rising levels of antimicrobial resistance will require a massive and coordinated global effort. Setting a collective direction for progress is the first step towards aligning global efforts on AMR. This process would be greatly accelerated by adopting a unifying global target — a well-defined global target that unites all countries and sectors. The proposed pandemic instrument — with its focus on prevention, preparedness and response — (...) represents an ideal opportunity to develop and adopt a unifying global target that catalyzes global action on AMR. We propose three key characteristics of a unifying global target for AMR that — if embedded within the pandemic preparedness instrument — could rally public support, funding, and political commitment commensurate with the scale of the AMR challenge. (shrink)

Antimicrobial resistance (AMR) is one of the defining global health threats of our time, but no international legal instrument currently offers the framework and mechanisms needed to address it. Fortunately, the actions needed to address AMR have considerable overlap with the actions needed to confront other pandemic threats.

I show that centered propositions—also called de se propositions, and usually modeled as sets of centered worlds—pose a serious problem for various versions of Lewis's Principal Principle. The problem, put roughly, is that in scenarios like Elga's `Sleeping Beauty' case, those principles imply that rational agents ought to have obviously irrational credences. To solve the problem, I propose a centered version of the Principal Principle. My version allows centered propositions to be objectively chancy.

When artificial intelligence (AI) is used to make high-stakes decisions, some worry that this will create a morally troubling responsibility gap—that is, a situation in which nobody is morally responsible for the actions and outcomes that result. Since the responsibility gap might be thought to result from individuals lacking knowledge of the future behavior of AI systems, it can be and has been suggested that deploying explainable artificial intelligence (XAI) techniques will help us to avoid it. These techniques provide humans (...) with certain forms of understanding of the systems in question. In this paper, I consider whether existing XAI techniques can indeed close the responsibility gap. I identify a number of significant limits to their ability to do so. Ensuring that responsibility for AI-assisted outcomes is maintained may require using different techniques in different circumstances, and potentially also developing new techniques that can avoid each of the issues identified. (shrink)

I propose a `stage theory’ of groups: a group is a fusion of group-stages, where a group-stage is a plurality of individuals at a world and a time. The stage theory consists of existence conditions, identity conditions, and parthood conditions for groups.

Suppose that, for reasons of animal welfare, it would be better if everyone stopped eating chicken. Does it follow that you should stop eating chicken? Proponents of the “inefficacy objection” argue that, due to the scale and complexity of markets, the expected effects of your chicken purchases are negligible. So the expected effects of eating chicken do not make it wrong. -/- We argue that this objection does not succeed, in two steps. First, empirical data about chicken production tells us (...) that the expected effects of consuming *many* chickens are not negligible. Second, this implies that the expected effect of consuming one chicken is ordinarily not negligible. *Parity* between your purchase and other counterfactual purchases and *uncertainty* about others’ consumption behavior each tend to pull the expected effect of a single purchase toward the average large scale effect. While some purchases do have negligible expected effects, many do not. (shrink)

Motus quidem veros corporum singulorum cognofcere , & ab apparentibus actu diícriminare, difficillimum est ; propterca quod partes ípatij illius immobilis in quo corpora vere moventur, non incurrunt in sensus.

In this enlightening study, a noted scholar elucidates the distinguishing characteristics of the works of several Jewish thinkers of the Middle Ages. In addition to summaries of the main arguments and teachings of Moses Maimonides, Isaac Israeli, Judah Halevi, Abraham Ibn Daud, Hillel ben Samuel, Levi ben Gerson, Joseph Albo, and many others, the author offers insightful analyses and commentary. Of particular value to beginners, this volume is also an ever-relevant resource for many issues of scholarly debate.

There have been several recent attempts to think about psychological kinds as homologies. Nevertheless, there are serious epistemic challenges for individuating homologous psychological kinds, or cognitive homologies. Some of these challenges are revealed when we look at competing claims of cognitive homology. This paper considers two competing homology claims that compare human anger with putative aggression systems of nonhuman animals. The competition between these hypotheses has been difficult to resolve in part because of what I call the boundary problem: boundaries (...) between instances of psychological kinds (e.g., anger and fear) cannot be directly observed. Thus, there are distinctive difficulties for individuating psychological kinds across lineages. I draw four conclusions from this case study: First, recent evidence from the neuroscience of fear suggests that one of the proposed homologies involves a straightforward conflation of anger and fear. Second, this conflation arises because of the boundary problem. Third, there is an implicit constraint on the operational criteria that is easy to overlook in the psychological case. In this case, ignoring the constraint is part of the problem. Fourth, this is a clear case in which knowledge of homology cannot be accumulated piecemeal. Identifying homologs of human anger requires identifying homologs of fear. (shrink)

This is a collection of Isaac Levi's philosophical papers. Over the period represented by the work here, Professor Levi has developed an interrelated set of views, in the tradition of Peirce and Dewey, on epistemology and the philosophy of science and social science. This focus has been on the problem of induction and the growth of knowledge, the foundations of probability and the theory of rational decision-making. His most important essays in these areas are assembled here, with an introduction (...) setting out their main themes and connections. As a whole the volume presents a coherent, elaborated position which will be of great interest to a range of philosophers, decision theorists, welfare and social choice theorists and cognitive scientists. (shrink)

In Logic, Watts address proper thinking under the four basic functions of the human mind: perception, judgment, reasoning, and disposition. In part one, Watts addresses human perception, the cultivation of ideas, and how we associate them with words. In part two, Watts treats human judgment and its ability to construct various kinds of propositions, while giving guidance for avoiding the formation of bad judgments. Part three covers our ability to reason, giving instruction on the use of syllogisms for constructing a (...) good argument. Part four discusses the mind's disposition as a method of arranging our thoughts for better understanding and memory. (shrink)

People increasingly form beliefs based on information gained from automatically filtered Internet ‎sources such as search engines. However, the workings of such sources are often opaque, preventing ‎subjects from knowing whether the information provided is biased or incomplete. Users’ reliance on ‎Internet technologies whose modes of operation are concealed from them raises serious concerns about ‎the justificatory status of the beliefs they end up forming. Yet it is unclear how to address these concerns ‎within standard theories of knowledge and justification. (...) To shed light on the problem, we introduce a ‎novel conceptual framework that clarifies the relations between justified belief, epistemic responsibility, ‎action, and the technological resources available to a subject. We argue that justified belief is subject to ‎certain epistemic responsibilities that accompany the subject’s particular decision-taking circumstances, ‎and that one typical responsibility is to ascertain, so far as one can, whether the information upon which ‎the judgment will rest is biased or incomplete. What this responsibility comprises is partly determined by ‎the inquiry-enabling technologies available to the subject. We argue that a subject’s beliefs that are ‎formed based on Internet-filtered information are less justified than they would be if she either knew how ‎filtering worked or relied on additional sources, and that the subject may have the epistemic ‎responsibility to take measures to enhance the justificatory status of such beliefs.‎. (shrink)

We present a novel model of individual people, online posts, and media platforms to explain the online spread of epistemically toxic content such as fake news and suggest possible responses. We argue that a combination of technical features, such as the algorithmically curated feed structure, and social features, such as the absence of stable social-epistemic norms of posting and sharing in social media, is largely responsible for the unchecked spread of epistemically toxic content online. Sharing constitutes a distinctive communicative act, (...) governed by a dedicated norm and motivated to a large extent by social identity maintenance. But confusion about this norm and its lack of inherent epistemic checks lead readers to misunderstand posts, attribute excess or insufficient credibility to posts, and allow posters to evade epistemic accountability—all contributing to the spread of epistemically toxic content online. This spread can be effectively addressed if people and platforms add significantly more context to shared posts and platforms nudge people to develop and follow recognized epistemic norms of posting and sharing. (shrink)

For the past fifty years anxiety over naturalism has driven debates in social theory. One side sees social science as another kind of natural science, while the other rejects the possibility of objective and explanatory knowledge. _Interpretation and Social Knowledge_ suggests a different route, offering a way forward for an antinaturalist sociology that overcomes the opposition between interpretation and explanation and uses theory to build concrete, historically specific causal explanations of social phenomena.

An increasingly prevalent approach to studying human cognition is to construe the mind as optimally allocating limited cognitive resources among cognitive processes. Under this bounded rationality approach (Icard in Philos Sci 85(1):79–101, 2018; Simon in Utility and probability, Palgrave Macmillan, 1980), it is common to assume that resource-bounded cognitive agents approximate normative solutions to statistical inference problems, and that much of the bias and variability in human performance can be explained in terms of the approximation strategies we employ. In this (...) paper, we argue that this approach restricts itself to an unnecessarily narrow scope of cognitive models, which limits its ability to explain how humans flexibly adapt their representations to novel environments. We argue that more attention should be paid to how we form our cognitive representations in the first place, and advocate for pluralistic framework which jointly optimizes over both representations and algorithms for manipulating them. We identify several fundamental trade-offs that manifest in this joint optimization, and draw on recent work to motivate a unified formal framework for this analysis. We illustrate a simplified version of this analysis with a case study in social cognition, and outline several new directions for research that this approach suggests. (shrink)

Why would God institute the practice of efficacious petitionary prayer? Why would God not simply give us what we need before we ask? I examine recently proposed solutions to this puzzle and argue that they are inadequate to explain why an omniscient and perfectly good God would act differently in response to prayer. I propose that God has reasons to not always maximize a creature’s good, even in a sinless world, and that petitionary prayer functions as a means to reward (...) those who trust God, to enable us to actively love those we cannot otherwise help, and to give the petitioner personal evidence of God’s existence and care for her, creating a virtuous cycle of increasing faith. I refine this proposal by responding to several objections involving human responsibility and the epistemology of divine action. Along the way, I offer several ways petitioners can recognize God’s having answered a prayer and how God might help us with some common obstacles to prayer. (shrink)

This paper deals with two different problems in which infinity plays a central role. I first respond to a claim that infinity renders counting knowledge-level beliefs an infeasible approach to measuring and comparing how much we know. There are two methods of comparing sizes of infinite sets, using the one-to-one correspondence principle or the subset principle, and I argue that we should use the subset principle for measuring knowledge. I then turn to the normalizability and coarse tuning objections to fine-tuning (...) arguments for the existence of God or a multiverse. These objections center on the difficulty of talking about the epistemic probability of a physical constant falling within a finite life-permitting range when the possible range of that constant is infinite. Applying the lessons learned regarding infinity and the measurement of knowledge, I hope to blunt much of the force of these objections to fine-tuning arguments. (shrink)

My aim in this paper is to give a philosophical analysis of the relationship between contingently available technology and the knowledge that it makes possible. My concern is with what specific subjects can know in practice, given their particular conditions, especially available technology, rather than what can be known “in principle” by a hypothetical entity like Laplace’s Demon. The argument has two parts. In the first, I’ll construct a novel account of epistemic possibility that incorporates two pragmatic conditions: responsibility and (...) practicability. For example, whether subjects can gain knowledge depends in some circumstances on whether they have the capability of gathering relevant evidence. In turn, the possibility of undertaking such investigative activities depends in part on factors like ethical constraints, economical realities, and available technology. In the second part of the paper, I’ll introduce “technological possibility” to analyze the set of actions made possible by available technology. To help motivate the problem and later test my proposal, I’ll focus on a specific historical case, one of the earliest uses of digital electronic computers in a scientific investigation. I conclude that the epistemic possibility of gaining access to scientific knowledge about certain subjects depends (in some cases) on the technological possibility for making responsible investigations. (shrink)

Classification of the history of science has a long history, and the essays in this Focus section explore that history and its consequences from several different angles. Two of the papers deal with how classifying schemes in bibliography have evolved. A third looks at the way archival organization has changed over the years. Finally, the last essay explores the intersection of human and machine classifying systems. All four contributions look closely at the ramifications of the digital revolution for the way (...) we organize the knowledge of the discipline. (shrink)

Strike action in healthcare has been a common global phenomenon. As such action is designed to be disruptive, it creates substantial ethical tension, the most cited of which relates to patient harm, that is, a strike may not only disrupt an employer, but it could also have serious implications for the delivery of care. This article systematically reviewed the literature on strike action in healthcare with the aim of providing an overview of the major justifications for strike action, identifying relative (...) strengths and shortcomings of this literature and providing direction for future discussions, and theoretical and empirical research. Three major themes emerged related to (1) the relationship between healthcare workers, patients and society; (2) the consequences of strike action; and (3) the conduct of strike action. Those who argue against strike action generally cite the harms of such action, particularly as it relates to patients. Many also argue that healthcare workers, because of their skills and position in society, have a special obligation to their patients and society more generally. Those who see this action as not only permissible but also, in some cases, necessary have advanced several points in response, arguing that healthcare workers do not necessarily have any special obligation to their patients or society, and even if so, this obligation is not absolute. Overwhelmingly, when talking about the potential risks of strike action, authors have focused on patient welfare and the impact that a strike could have. Several directions for future work are identified, including greater explorations into how structural and systemic issues impact strike action, the need for greater consideration about the contextual factors that influence the risks and characteristics of strike action and finally the need to tie this literature to existing empirical evidence. (shrink)

Our decision-theoretic states are not luminous. We are imperfectly reliable at identifying our own credences, utilities and available acts, and thus can never be more than imperfectly reliable at identifying the prescriptions of decision theory. The lack of luminosity affords decision theory a remarkable opportunity — to issue guidance on the basis of epistemically inaccessible facts. We show how a decision theory can guarantee action in accordance with contingent truths about which an agent is arbitrarily uncertain. It may seem that (...) such advantages would require dubiously adverting to externalist facts that go beyond the internalism of traditional decision theory, but this is not so. Using only the standard repertoire of decision-theoretic tools, we show how to modify existing decision theories to take advantage of this opportunity. These improved decision theories require agents to maximize conditional expected utility — expected utility conditional upon an agent’s actual decision situation. We call such modified decision theories ‘self-confident’. These self-confident decision theories have a distinct advantage over standard decision theories: their prescriptions are better. (shrink)

Presents Newton's unifying idea of gravitation and explains how he converted physics from a science of explanation into a general mathematical system.

David Chalmers thinks his iPhone exemplifies the extended mind thesis by meeting the criteria ‎that he and Andy Clark established in their well-known 1998 paper. Andy Clark agrees. We take ‎this proposal seriously, evaluating the case of the GPS-enabled smartphone as a potential mind ‎extender. We argue that the “trust and glue” criteria enumerated by Clark and Chalmers are ‎incompatible with both the epistemic responsibilities that accompany everyday activities and the ‎practices of trust that enable users to discharge them. Prospects (...) for revision of the original ‎criteria are dim. We therefore call for a rejection of the trust criterion and a reevaluation of the ‎extended mind thesis.‎. (shrink)

(I) MATHEMATICAL LECTURES. LECTURE I. Of the Name and general Division of the Mathematical Sciences. BEING about to treat upon the Mathematical Sciences, ...

This book draws on fields as diverse as biochemistry, physiology, pharmacology, psychology, psychiatry, and ethology, to form a fascinating synthesis of information on the nature of fear and of panic and anxiety disorders. Dr. Marks offers both a detailed discussion of the clinical aspects of fear-related syndromes and a broad exploration of the sources and mechanisms of fear and defensive behavior. Dealing first with normal fear, he establishes a firm, scientific basis for understanding it. He then presents a thorough analysis (...) of the development, symptoms and treatment of fear-related syndromes. Phobic and obsessive-compulsive disorders are examined in detail. The book is illustrated with examples of fear and defensive behavior in other living organisms. By drawing provocative analogies between animal and human behavior, it sheds new light on the origins of fears, phobias, and obsessive-compulsive problems, as well as on their treatment by drugs and psychological means. Clinical psychologists, ethologists, and anyone interested in the mechanisms of behavior will be fascinated by this authoritative study. The text is intriguing and informative, and the bibliography of over 2,100 entries makes it an invaluable reference. (shrink)

There is a growing sentiment that federal student loans should be allocated according to students’ expected earning potential. If federal student loans were given so that the government could make a profit, then such a system would make sense. But this is not so. Instead, the US government issues student loans with the goal of benefiting society—and, in particular, of benefitting the loan recipients themselves. Although some of this benefit is expressed in higher earning potential, much of it is not. (...) In this chapter, we argue that the federal student loan system should be structured to account for the intrinsic values that accrue to individuals both from increased education and from certain occupational choices. (shrink)

I propose to examine what I take to be the point at issue between subjectivist and objectivist theories of ethics and to explain that the controversy between them is unreal. It springs from a misunderstanding of the nature of appraisal sentences. What I hope to show is that if such sentences were really analysable in the way in which the critics and many of the supporters of subjectivist theories suppose, then those theories would indeed, as it is sometimes put “fail (...) to do justice to the facts of moral experience.” But it seems to me that objectivist theories are no better off. They make exactly the same mistake though in a more sophisticated way. I therefore propose to see whether any useful results can be achieved by construing appraisal sentences on rather different lines. By appraisal sentences I mean sentences of the form “I approve of …, I think well of …, I commend …, etc.” I shall call these simple appraisals, sentences of the form “… is good, … is meritorious, … is praiseworthy, etc.” I shall call these moral appraisals. In these terms, subjectivist theories assert that moral appraisals can always be expressed without change of meaning by simple appraisals, though perhaps the addition of an imperative sentence of some kind is required to complete the translation. Objectivist theories deny this possibility and claim that moral appraisals assert truths about the independent world and not psychological facts about the speaker. (shrink)

This major work challenges some widely held positions in epistemology - those of Peirce and Popper on the one hand and those of Quine and Kuhn on the other.