There is growing interest in the evolutionary dynamics of molecular genetic pathways and networks, and the extent to which the molecular evolution of a gene depends on its position within a pathway or network, as well as over‐all network topology. Investigations on the relationships between network organization, topological architecture and evolutionary dynamics provide intriguing hints as to how networks evolve. Recent studies also suggest that genetic pathway and network structures may influence the action of evolutionary forces, and may play a (...) role in maintaining phenotypic robustness in organisms. BioEssays 26:479–484, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This paper reports on the design and implementation of a multi-phase interactive process among a set of scientists, policy makers, land managers, and community representatives, so as to facilitate communication, mutual understanding, and participative decision making. This was part of the Ecosystem Services Project in Australia. The project sought to broaden public understanding about the natural ecosystems in Australia. The study reported here pertains to one of the project sites--the Goulburn Broken catchment, a highly productive agricultural watershed in the south-east (...) of Australia. The paper demonstrates how, starting from a condition of diversity of ideas and interests among the participants, systematic dialogue and mutual learning could be generated, leading to identification of options for more sustainable land management practices. The concept of "ecosystem services" was used as an integrative tool across disciplines and community perspectives. The concept of scenarios was used to encourage future-focussed thinking among the participants. The idea of "stakeholder jury" was used to promote deliberation. A process of multi-criteria evaluation was used to facilitate convergence of viewpoints, through informed trade-offs and compromises. This experience led to the development of a process for integration research, which helped in harmonising across diverse understandings and values in a transparent and structured manner. (shrink)

In 1967 Alan Cameron published a landmark article in this journal, ‘The fate of Pliny'sLettersin the late Empire’. Opposing the traditional thesis that the letters of Pliny the Younger were only rediscovered in the mid to late fifth century by Sidonius Apollinaris, Cameron proposed that closer attention be paid to the faint but clear traces of the letters in the third and fourth centuries. On the basis of well-observed intertextual correspondences, Cameron proposed that Pliny's letters were being read by the (...) end of the fourth century at the latest. That article now seems the vanguard of a rise in scholarly interest in Pliny's late-antique reception. But Cameron also noted the explicit attention given to the letters by two earlier commentators—Tertullian of Carthage, in the late second to early third century, and Eusebius of Caesarea, in the early fourth. The use of Pliny in these two earliest commentators, in stark contrast to their later successors, has received almost no subsequent attention. (shrink)

For more than 200 years scholars have proceeded on the assumption that there was a controversy (in the sense of an argumentative exchange) between the bishop of Cork and Ross, Peter Browne (c. 1665–1735), and his nowadays more famous contemporary, the bishop of Cloyne, George Berkeley (1685–1753) about what we might call ‘the problem of divine attributes’. This problem concerns one of the most vexing issues for 17th /18th century Irish intellectuals. Simply put, it turns on two interconnected questions, (...) namely (1) an ontological question regarding God’s attributes and (2) a semantical question regarding the proper conception of analogy: -/- (1) Do God’s attributes only differ in degree or also in kind from their human counterparts? -/- (2) Is “analogical attribution” only concerned with the structure or the modus of the attribution? That is, is it a separate mode of speech (apart from the metaphorical and literal) or does it just mean we have to use analogies for our divine attributions? -/- In regard to the first question Berkeley argues the attributes of God and humans only differ in degree but not in kind (Alc. 4.22). Browne, on the other hand, is convinced that human and divine attributes differ in kind: “What Knowledge and Goodness are in the Nature of Man, that some inconceivable but correspondent Perfections are in the Nature of God […] which tho’ totally different in Kind from those Properties in us bearing the same Name” (Procedure, 138). Furthermore, Berkeley rejects the notion that analogical attribution is a separate mode of speech in addition to the literal and the metaphorical. Rather, it is an attribution made in the form of an analogy in which the words can be used literally or metaphorically (Alc. 4.21). By contrast, Browne repeatedly insists analogical attribution is more than just using analogies for attributing something to God. He thinks it is a separate mode of speech that ought to be distinguished from literal and metaphorical language (Procedure, 12, 23–29, 123–46). -/- Hence, there can be no doubt that Browne and Berkeley advance conflicting solutions to the problem of divine attributes. Yet, advancing disagreeing positions is not the same as having a (heated) argumentative exchange, i.e., a controversy. In contrast to the controversy-reading, I will defend the following view: Browne surely felt attacked by Berkeley’s elaborations in Alciphron (1732) and reacted to them in his Divine Analogy (1732/3). However, there was no argumentative exchange because Browne’s Procedure (1728) had virtually no influence on Berkeley when he was writing Alciphron. Furthermore, the available evidence suggests that Berkeley was indifferent to the (elaborate) criticisms of Alciphron found in Browne’s Divine Analogy. Thus, while the two bishops have differing positions and Browne reacted to Berkeley there is no reaction on Berkeley’s part and hence there is no argumentative exchange between the two at all, which is why their differing opinions are best described as such and not as a controversy. (shrink)

In general anesthesia, a “cocktail” of drugs renders a patient unconscious, in what has been called a “controlled coma”. Various measures of patient awareness involve overt behavior, autonomic nervous system activity, processed EEG, and event‐related potentials. The incidence of intraoperative awareness is very low, but anecdotal reports suggest that patients might process surgical events unconsciously, leading to unconscious postoperative memories. Careful experimental studies show that priming effects, similar to those observed in implicit memory, can be spared even in the absence (...) of conscious recollection, an outcome which indicates that unconscious perception can occur even in clinically adequate general anesthesia. Deeper planes of amnesia, however, appear to abolish both explicit and implicit perception. (shrink)

Determining the agency-status of machines and AI has never been more pressing. As we progress into a future where humans and machines more closely co-exist, understanding hallmark features of agency affords us the ability to develop policy and narratives which cater to both humans and machines. This paper maintains that decision-making processes largely underpin agential action, and that in most instances, these processes yield good results in terms of making good choices. However, in some instances, when faced with two (or (...) more) choices, an agent may find themselves with equal reasons to choose either - thus being presented with a tie. This paper argues that in the event of a tie, the ability to create a voluntarist reason is a hallmark feature of agency, and second, that AI, through current tie-breaking mechanisms does not have this ability, and thus fails at this particular feature of agency. (shrink)

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Intuition—spontaneous, nondeliberative assessment—has long been indispensable in theoretical and practical philosophy alike. Recent research by psychologists and experimental philosophers has challenged our understanding of the nature and authority of moral intuitions by tracing them to “fast,” “automatic,” “button-pushing” responses of the affective system. This view of the affective system contrasts with a growing body of research in affective neuroscience which suggests that it is instead a flexible learning system that generates and updates a multidimensional evaluative landscape to guide decision and (...) action. With this latter view in mind, I revisit some of the classic hypothetical scenarios used in experimental moral psychology. (shrink)

It has been the dominant view that probabilistic explanations of particular facts must be inductive in character. I argue here that this view is mistaken, and that the aim of probabilistic explanation is not to demonstrate that the explanandum fact was nomically expectable, but to give an account of the chance mechanism(s) responsible for it. To this end, a deductive-nomological model of probabilistic explanation is developed and defended. Such a model has application only when the probabilities occurring in covering laws (...) can be interpreted as measures of objective chance, expressing the strength of physical propensities. Unlike inductive models of probabilistic explanation, this deductive model stands in no need of troublesome requirements of maximal specificity or epistemic relativization. (shrink)

In our everyday lives we struggle with the notions of why we do what we do and the need to assign values to our actions. Somehow, it seems possible through experience and life to gain knowledge and understanding of such matters. Yet once we start delving deeper into the concepts that underwrite these domains of thought and actions, we face a philosophical disappointment. In contrast to the world of facts, values and morality seem insecure, uncomfortably situated, easily influenced by illusion (...) or ideology. How can we apply this same objectivity and accuracy to the spheres of value and morality? In the essays included in this collection, Peter Railton shows how a fairly sober, naturalistically informed view of the world might nonetheless incorporate objective values and moral knowledge. This book will be of interest to professionals and students working in philosophy and ethics. (shrink)

Statements about a person's good slip into and out of our ordinary discourse about the world with nary a ripple. Such statements are objects of belief and assertion, they obey the rules of logic, and they are often defended by evidence and argument. They even participate in common-sense explanations, as when we say of some person that he has been less subject to wild swings of enthusiasm and disappointment now that, with experience, he has gained a clearer idea of what (...) is good for him. Statements about a person's good present themselves as being about something with respect to which our beliefs can be true or false, warranted or unwarranted. Let us speak of these features as the descriptive side of discourse about a person's good. (shrink)

I’ve been told that there are two principal approaches to drawing figures from life. One begins by tracing an outline of the figure to be drawn, locating its edges and key features on an imagined grid, and then using perspective to fill in depth. The other approach proceeds from the ‘center of mass’ of the subject, seeking to build up the image by supplying contour lines, the intersections of which convey depth—as if the representation were being created in relief. The (...) second approach need not adopt a unified perspective, and is more concerned with evoking the volume and ‘presence’ of the subject than with accurate placement of edges and features. Call this second approach drawing ‘from the inside out’, meant to capture the living force of the subject rather than freeze it in a coordinate frame. (shrink)

The literature on deep brain stimulation (DBS) and adaptive DBS (aDBS) raises concerns that these technologies may affect personality, mood, and behavior. We conducted semi-structured interviews with researchers (n = 23) involved in developing next-generation DBS systems, exploring their perspectives on ethics and policy topics including whether DBS/aDBS can cause such changes. The majority of researchers reported being aware of personality, mood, or behavioral (PMB) changes in recipients of DBS/aDBS. Researchers offered varying estimates of the frequency of PMB changes. A (...) smaller majority reported changes in personality specifically. Some expressed reservations about the scientific status of the term ‘personality,’ while others used it freely. Most researchers discussed negative PMB changes, but a majority said that DBS/aDBS can also result in positive changes. Several researchers viewed positive PMB changes as part of the therapeutic goal in psychiatric applications of DBS/aDBS. Finally, several discussed potential causes of PMB changes other than the device itself. (shrink)

An adequate theory of the nature of belief should help us explain the most obvious features of belief as we find it. Among these features are: guiding action and reasoning non-inferentially; varying in strength in ways that are spontaneously experience-sensitive; ‘aiming at truth’ in some sense and being evaluable in terms of correctness and warrant; possessing inertia across time and constancy across contexts; sustaining expectations in a manner mediated by propositional content; shaping the formation and execution of plans; generalizing spontaneously (...) projectively; and being independent of the will and resisting instrumentalization. Using the method of ‘creature construction’, I attempt to show how we can build an attitude with these features step-by-step from simpler components, thereby avoiding the problems of regress or circularity affecting a number of influential accounts of belief. (shrink)

In this article, we sketch how theoretical neuroethics can clarify the concept of autonomy. We hope that this can both serve as a model for the conceptual clarification of other components of PIAAAS and contribute to the development of the empirical measures that Gilbert and colleagues [1] propose.

Recent decades have witnessed a sea change in thinking about emotion, which has gone from being seen as a disruptive force in human thought and action to being seen as an important source of situation- and goal-relevant information and evaluation, continuous with perception and cognition. Here I argue on philosophical and empirical grounds that the role of emotion in contributing to our ability to respond to reasons for action runs deeper still: The affective system is at the core of the (...) process of evaluatively modeling situations, actions, and outcomes, which is the foundation upon which rational deliberation and action can be built. Taking up this perspective affords new approaches to long-standing problems in the theory of reason-based action. (shrink)

In this article, we sketch how theoretical neuroethics can clarify the concept of autonomy. We hope that this can both serve as a model for the conceptual clarification of other components of PIAAAS and contribute to the development of the empirical measures that Gilbert and colleagues [1] propose.

Conceptual combination performs a fundamental role in creating the broad range of compound phrases utilised in everyday language. This article provides a novel probabilistic framework for assessing whether the semantics of conceptual combinations are compositional, and so can be considered as a function of the semantics of the constituent concepts, or not. While the systematicity and productivity of language provide a strong argument in favor of assuming compositionality, this very assumption is still regularly questioned in both cognitive science and philosophy. (...) Additionally, the principle of semantic compositionality is underspecifi ed, which means that notions of both "strong" and "weak" compositionality appear in the literature. Rather than adjudicating between different grades of compositionality, the framework presented here contributes formal methods for determining a clear dividing line between compositional and non-compositional semantics. In addition, we suggest that the distinction between these is contextually sensitive. Compositionality is equated with a joint probability distribution modeling how the constituent concepts in the combination are interpreted. Marginal selectivity is introduced as a pivotal probabilistic constraint for the application of the Bell/CH and CHSH systems of inequalities. Non-compositionality is equated with a failure of marginal selectivity, or violation of either system of inequalities in the presence of marginal selectivity. This means that the conceptual combination cannot be modeled in a joint probability distribution, the variables of which correspond to how the constituent concepts are being interpreted. The formal analysis methods are demonstrated by applying them to an empirical illustration of twenty-four non-lexicalised conceptual combinations. (shrink)

It is common for organizational theorists as well as business practitioners to speak of an organization's visions, strategies, goals and responsibilities. This implies that collectivities have competencies normally attributed to individuals, i.e. to reflect, evaluate, learn and make considered choices. The article provides a series of reflections on the concept of consciousness in an organizational context. It is argued that, under certain conditions, it is both meaningful and efficacious to ascribe the competency for conscious and intentional behavior to organizations. The (...) arguments provided are based on empirical observations, common sense and deductive reasoning. (shrink)

Critiques existing theoretical approaches and practices of philosophical counseling and presents a new model.

Peter Anstey presents a thorough and innovative study of John Locke's views on the method and content of natural philosophy. Focusing on Locke's Essay concerning Human Understanding, but also drawing extensively from his other writings and manuscript remains, Anstey argues that Locke was an advocate of the Experimental Philosophy: the new approach to natural philosophy championed by Robert Boyle and the early Royal Society who were opposed to speculative philosophy. On the question of method, Anstey shows how Locke's pessimism (...) about the prospects for a demonstrative science of nature led him, in the Essay, to promote Francis Bacon's method of natural history, and to downplay the value of hypotheses and analogical reasoning in science. But, according to Anstey, Locke never abandoned the ideal of a demonstrative natural philosophy, for he believed that if we could discover the primary qualities of the tiny corpuscles that constitute material bodies, we could then establish a kind of corpuscular metric that would allow us a genuine science of nature. It was only after the publication of the Essay, however, that Locke came to realize that Newton's Principia provided a model for the role of demonstrative reasoning in science based on principles established upon observation, and this led him to make significant revisions to his views in the 1690s. On the content of Locke's natural philosophy, it is argued that even though Locke adhered to the Experimental Philosophy, he was not averse to speculation about the corpuscular nature of matter. Anstey takes us into new terrain and new interpretations of Locke's thought in his explorations of his mercurialist transmutational chymistry, his theory of generation by seminal principles, and his conventionalism about species. (shrink)

The orthodox, empiricist covering-law account of scientific explanation, as developed by C. G. Hempel and others, has long dominated philosophical discussions of scientific explanation. In recent years it has met overwhelming critical resistance. We should give up this account of scientific ex.

There has been a groundswell of interest in the account of modality that Kant sets forth in his pre-Critical Only Possible Argument. Andrew Chignell's reconstruction of Kant's theistic argument in terms of what he calls has a prima facie advantage in that it appears to be able to block the plurality objection (namely, that even if every modal fact presupposes some ground, this does not entail that all modal facts share the same ground). I argue that it is both textually (...) and philosophically problematic to interpret Kant's argument in terms of real harmony. Then, I set forth an alternative response to the plurality objection which does not require the adoption of the problematic notion of real harmony. Instead, I argue that the objection can be overcome by observing that the argument seeks to ground modal facts as a totality and that, according to Kant, such relations can be accounted for only by their schematization in a single intellect. (shrink)

While Wilfrid Sellars’ philosophy is often depicted in an ahistorical fashion, this book explores the consequences of placing his work in its historical context. In order to show how Sellars’ early publications depend on contextual factors, Peter Olen reconstructs the conceptions of language, psychological, and social explanation that dominated American philosophy in the early 20th century. Because of Sellars’ differing explanations of language and behaviour, Olen argues that many of Sellars’ early commitments are incompatible with his later works. In (...) the course of doing so, Olen highlights problematic tensions between Sellars’ early and later conceptions of language, meta-philosophy, and normativity. Supplementing the main text is a collection of previously unpublished archival material from Wilfrid Sellars, Gustav Bergmann, Everett Hall, and other early 20th century philosophers. This text will be a useful resource to those with an interest in the history of American philosophy, the history of analytic philosophy, Wilfrid Sellars’ philosophy, and the myriad issues surrounding normativity and language. (shrink)

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