Mitochondria, the powerhouses of our cells, are essential to life. Normal mitochondrial function is achieved through the cooperative interaction of the nuclear and mitochondrial genomes. New IVF approaches intended to circumvent devastating mitochondrial disease look set to change the ancient pattern of mtDNA inheritance and interaction with unknown consequences.

The human Y chromosome contains very low levels of nucleotide variation. It has been variously hypothesized that this invariance reflects historic reductions in the human male population, a very recent common ancestry, a slow rate of molecular evolution, an inability to evolve adaptively, or frequent selective sweeps acting on genes borne on the Y chromosome. We propose an alternative theory in which human Y chromosome evolution is driven by mutations in the maternally inherited mitochondrial genome, which impair male fertility and (...) ultimately lead to a reduction in the effective population size (Ne) and consequently the variability of the Y chromosome. BioEssays 24:275–279, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10062. (shrink)

Mitochondrial function is achieved through the cooperative interaction of two genomes: one nuclear (nuDNA) and the other mitochondrial (mtDNA). The unusual transmission of mtDNA, predominantly maternal without recombination is predicted to affect the fitness of male offspring. Recent research suggests the strong sexual dimorphism in aging is one such fitness consequence. The uniparental inheritance of mtDNA results in a selection asymmetry; mutations that affect only males will not respond to natural selection, imposing a male‐specific mitochondrial mutation load. Prior work has (...) implicated this male‐specific mutation load in disease and infertility, but new data from fruit flies suggests a prominent role for mtDNA in aging; across many taxa males almost invariably live shorter lives than females. Here we discuss this new work and identify some areas of future research that might now be encouraged to explore what may be the underpinning cause of the strong sexual dimorphism in aging.Editor's suggested further reading in BioEssays: Mitonuclear match: Optimizing fitness and fertility over generations drives ageing within generations AbstractMitochondrial manoeuvres: Latest insights and hypotheses on mitochondrial partitioning during mitosis in Saccharomyces cerevisiae AbstractMitochondria and the culture of the Borg Abstract. (shrink)

Microsatellites are among the most versatile of genetic markers, being used in an impressive number of biological applications. However, the evolutionary dynamics of these markers remain a source of contention. Almost 20 years after the discovery of these ubiquitous simple sequences, new genomic data are clarifying our understanding of the structure, distribution and variability of microsatellites in genomes, especially for the eukaryotes. While these new data provide a great deal of descriptive information about the nature and abundance of microsatellite sequences (...) within eukaryotic genomes, there have been few attempts to synthesise this information to develop a global concept of evolution. This review provides an up‐to‐date account of the mutational processes, biases and constraints believed to be involved in the evolution of microsatellites, particularly with respect to the creation and degeneration of microsatellites, which we assert may be broadly viewed as a life cycle. In addition, we identify areas of contention that require further research and propose some possible directions for future investigation. BioEssays 28: 1040–1050, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

This study focuses on current jurisprudential debate between the "positivist" views of Herbert Hart and the "rights thesis" of Ronald Dworkin. MacCormick provides a critical analysis of the Dworkin position while also modifying Hart's. It stands firmly on its own as a contribution to an extensive literature.

What makes an argument in a law case good or bad? This book examines this and other questions central to the study of jurisprudence. Care has been taken to make the legal elements of the book readily accessible to non-lawyers, and the philosophical elements to non-philosophers.

Dewey continues to offer arguments that remain powerful on the need to break down the divisions between ‘academic’ and ‘vocational’ in terms of his specific theory of knowledge. Dewey's writings are used to argue that a democratic curriculum needs to challenge such divisions to encompass the many forms of knowledge necessary in the contemporary classroom. Gandin and Apple's investigation of community participation (Orçamento Participativo or Participatory Budgeting) in the curriculum of the Citizen School in Porto Alegre, Brazil, will be explored (...) as an example of democratic structures informing educational planning. The work of Paul Hirst, Atli Harđarson and Chris Jane Brough is analysed regarding the issue of curriculum aims and student negotiation. Dewey's emphasis on learning as a collective enterprise will resonate here. Brough offers innovative research on student-centred curriculum integration that suggests even very young children are able to participate in debate over their own learning. Hirst and Harđarson provide contrasting views on the issue of curriculum aims—Hirst arguing that a curriculum cannot exist without definable aims while Harđarson challenges the very notion of settled aims if students are to be reflexive regarding their education. The article also refers to the work of Alexander on the use of dialogic questioning in the classroom. Such questioning, it is suggested, enhances and encourages collaborative forms of enquiry necessary for a democratic curriculum through discussion between teachers, students and other stakeholders. (shrink)

The period after the repulse of Xerxes' invasion is one of the more obscure in Greek history, and this is particularly true of the eclipse of Themistokles and the history of the Peloponnese in the seventies and sixties. On the period of Themistokles' ostracism before the flight which led him to Persia Thucydides says only that he was ostracized and lived at Argos while also travelling to the rest of the Peloponnese. Other writers add a few details to Thucydides' account (...) on other aspects of the ostracism, but tell us even less on the sojourn in Argos. Diodoros and Plutarch merely tell us that he lived there in exile while Nepos informs us that Themistokles' virtuous and dignified life in Argos aroused resentment. Now Themistokles did not remain inactive in exile. The Spartans had some good reason to wish to remove him from Argos. The activities which aroused the Spartans' distrust are probably referred to by Thucydides' remark that Themistokles journeyed to the rest of the Peloponnese. It is usually concluded that Themistokles was involved in the creation of an anti-Spartan coalition and that a major part of this policy may have been the establishment of democratic governments in and the synoecism of the cities of Elis and Mantineia. But we lack any clear evidence on Themistokles' actions in this period and the hypothesis rests principally on deductions from two brief passages. The first is from Herodotos and records that in 479 b.c. the Mantineian and Eleian contingents arrived too late to take part in the battle of Plataia and on their return both cities banished their commanders. (shrink)

We look for a converse to a result from [N. Thapen, A model-theoretic characterization of the weak pigeonhole principle, Annals of Pure and Applied Logic 118 175–195] that if the weak pigeonhole principle fails in a model K of bounded arithmetic, then there is an end-extension of K interpretable inside K. We show that if a model J of an induction-free theory of arithmetic is interpretable inside K, then either J is isomorphic to an initial segment of K , or (...) K is isomorphic to an initial segment of J and in this case the weak pigeonhole principle fails in K. This result is formulated in terms of a theory of bounded arithmetic with a greatest element. We go on to consider structures defined by oracles, and use the probabilistic witnessing theorem for to give a general criterion for what can be proved about these using the weak pigeonhole principle. We also show that the injective WPHP is not provable in this theory in the relativized case. (shrink)

In this article we assess the extant literature on women’s careers appearing in selected career, management and psychology journals from 1990 to the present to determine what is currently known about the state of women’s careers at the dawn of the 21st century. Based on this review, we identify four patterns that cumulatively contribute to the current state of the literature on women’s careers: women’s careers are embedded in women’s larger-life contexts, families and careers are central to women’s lives, women’s (...) career paths reflect a wide range and variety of patterns, and human and social capital are critical factors for women’s careers. We also identify paradoxes that highlight the disconnection between organizational practice and scholarly research associated with each of the identified patterns. Our overall conclusion is that male-defined constructions of work and career success continue to dominate organizational research and practice.We provide direction for a research agenda on women’s careers that addresses the development of integrative career theories relevant for women’s contemporary lives in hopes of providing fresh avenues for conceptualizing career success for women. Propositions are identified for more strongly connecting career scholarship to organizational practice in support of women’s continued career advancement. (shrink)

I highlight a neglected but striking phenomenological fact about our experiences: they have a pervasively spatial character. Specifically, all (or almost all) phenomenal qualities – roughly, the introspectible, philosophically puzzling properties that constitute ‘what it’s like’ to have an experience – introspectively seem instantiated in some kind of space. So, assuming a very weak charity principle about introspection, some phenomenal qualities are instantiated in space. But there is only one kind of space – the ordinary space occupied by familiar objects. (...) And the only objects appropriately located in ordinary space are outside the subject’s mind. This entails experiential externalism, the view that at least one phenomenal quality is instantiated outside the subject’s mind. Experiential externalism is incompatible with many leading theories of experience, including certain mental paint theories; some forms of representationalism; paradigmatic versions of sense-datum theory; and views on which no phenomenal qualities are instantiated. My argument is structurally similar to familiar arguments based on the ‘transparency of experience.’ However, I suggest, phenomenological intuitions about spatiality are considerably more stable than phenomenological intuitions about transparency. For many philosophers, transparency intuitions fade markedly with respect to non-standard experiences, including experiences associated with blurry or double vision. But spatiality intuitions remain robust even for these experiences. Thus, spatiality intuitions should be more dialectically effective than transparency intuitions for supporting experiential externalism. (shrink)

This article uses nationwide survey data to answer two questions: who participates in environmental governance in China and why? First it explores the social structural characteristics that distinguish participants, finding that city dwellers, the more educated and those with higher incomes and higher social status are more likely to participate, while women, the elderly, those with rural residence registration and migrants are less likely. It then tests two main explanations as to why people participate in environmental governance: instrumentality and identity. (...) Participation is associated with attention to conservation issues, the perceived effectiveness of local environmental governance, knowledge of environmental problems, reading newspapers and magazines, voting in local elections, identification with a middle-class lifestyle and observance of Western holidays. Combining the analyses into a structural model shows that instrumental and identity-related variables account for nearly all of the social structural variation in participation. Participation is thus a function both of instrumental considerations and identities. (shrink)

A Transition to Proof: An Introduction to Advanced Mathematics describes writing proofs as a creative process. There is a lot that goes into creating a mathematical proof before writing it. Ample discussion of how to figure out the "nuts and bolts'" of the proof takes place: thought processes, scratch work and ways to attack problems. Readers will learn not just how to write mathematics but also how to do mathematics. They will then learn to communicate mathematics effectively. The text emphasizes (...) the creativity, intuition, and correct mathematical exposition as it prepares students for courses beyond the calculus sequence. The author urges readers to work to define their mathematical voices. This is done with style tips and strict "mathematical do’s and don’ts", which are presented in eye-catching "text-boxes" throughout the text. The end result enables readers to fully understand the fundamentals of proof. Features: The text is aimed at transition courses preparing students to take analysis Promotes creativity, intuition, and accuracy in exposition The language of proof is established in the first two chapters, which cover logic and set theory Includes chapters on cardinality and introductory topology. (shrink)

This question takes us to the very center of the cooperation of the human powers in the act of choice. If prudence is wanting, that act of dominion is neither truly human nor truly praiseworthy. Unless there can be truly praiseworthy human excellence in the absence of love the answer to our question ought to be affirmative. Surely the affirmative answer is favored by I Cor. 13:13 and John 14:23. Is the dominion then still human? A negative answer to the (...) question of our title is favored by what seems an Aristotelian firmness. Prudence, then, with that negative answer is nothing but knowledge? Yet Thomas Aquinas says in a very simple text: “love moves within prudential actuality”. These words in answer to the question of our title invite their metaphysical exegesis by penetrating causal relations within the prudential judgment. (shrink)

Clinical ethics consultants are inevitably called to participate in and bear witness to emotionally challenging cases. With the move toward the professionalization of ethics consultants, the responsibility to respond to and address difficult ethical dilemmas is likely to fall to a small set of people or a single clinical ethicist. Combined with time constraints, the urgent nature of these cases, and the moral distress of clinicians and staff encountered during consultation, like other healthcare professionals such as physicians and nurses, clinical (...) ethics consultants could risk burnout. If it is true that clinical ethicists are at risk for burnout, an important strategy to avoid burnout is to develop sound self-care practices. This article reviews the goals and skills of ethics consultation and the role-specific reasons that clinical ethicists may be at risk for burnout, and argues that clinical ethicists may need to engage in self-care practices. Strategies to address burnout are reviewed and opportunities for future research are identified. (shrink)

The ArgumentPressures to lower health-care costs remain an important stimulus to eugenic approaches. Prenatal diagnosis followed by abortion of affected fetuses has replaced sterilization as the major eugenic technique. Voluntary acceptance has replaced coercion, but subtle pressures undermine personal autonomy. The failure of the old eugenics to accurately predict who will have affected offspring virtually disappears when prenatal diagnosis is used to predict Mendelian disorders. However, when prenatal diagnosis is used to detect inherited susceptibilities to adult-onset, common, complex disorders, considerable (...) uncertainty is inherent in the prediction. Intolerance and the resurgence of genetic determinism are current pressures for a eugenic approach. The increasing use of carrier screening and of prenatal diagnosis could itself generate intolerance for those who refuse the procedures. Genetic determinism deflects society from social action that would reduce the burden of disease far more than even the maximum use of eugenics. (shrink)

Dialectics of Knowing strengthens the philosophical basis of formal education that has been weakened by neoliberalism over the past thirty years. It draws upon Greek philosophy that asked 'How should we live?' and European Enlightenment that considered 'What can we know?' to question today 'What does it mean to experience mind, to act, think and create ethically?' Focusing particularly on the notion of praxis and specific issues involving indigenous, feminist and practitioner knowing, this book will help scholars and practitioners to (...) transform their education theories and practices in ways that encourage democracy, emancipation, social action, culture, inquiry and creativity. (shrink)

If we are to understand why psychoanalysis extends ordinary psychology in the precise ways that it does, we must take account of the existence of, and the interplay between, two distinct kinds of explanatory concern: functional and idiographic. The form and content of psychoanalytic explanation and its unusual methodology can, at least in part, be viewed as emerging out of Freud's attempt to reconcile these two types of explanatory concern. We must also acknowledge the role of the background theoretical context (...) that shapes Freud's functional thinking about the mind. A neglect of the role of the background theory in shaping the extension of ordinary psychology leaves us with puzzles about the nature and direction of the psychoanalytic extension and gives rise to an unbelievable history of psychoanalysis. (shrink)

Peacocke argues for a ‘generalized rationalism’, holding that ‘all entitlement has a fundamentally a priori component.’ (2) But his rationalism ‘differs from those of Frege and Gödel, just as theirs differ from that of Leibniz.’ He requires both substantive theories of intentional content and of understanding, and systematic formal theories of referential semantics and truth. We need an externalist theory of content: ‘Only mental states with externally individuated contents can make judgements about the external, mind-independent world rational.’ (123) Purely evidential (...) conceptions of meaning and content are inadequate. (34-49) They cannot account for the following: a thinker often has to work out what would be evidence for a content; contents cannot depend, for their identity, on all of the infinitely ramifying evidential connections among them; and thinkers conceive, however tacitly, of (at least some) observed properties as categorical. By contrast with an evidential theory, a truthconditional theory of content can account for all these problematic facts. Peacocke states, develops and defends three principles of rationalism which collectively ‘relate entitlement to truth, to the identity of states and their intentional contents, and to the a priori.’ (3-4) He does not thoroughly explain his central notion of entitlement, but this much is clear: any thinker is entitled to various transitions in, or into, thought. An example of a transition into thought would be that from one’s perceptual experience to an observational judgment. An example of a transition in thought would be a logical inference from certain premises to a conclusion. A transition is rational just in case the thinker is entitled to it. (Note that this aims to explain rationality in terms of entitlement, not the other way round.) It is clear from 28 that Peacocke needs an abstract ontology of entitlements (such as proofs, in the case of mathematics). Yet he does not endorse ‘Gödel’s obscure quasi-perceptual and quasi-causal epistemology of mathematics and the abstract sciences.’ (54.. (shrink)