The male gametes of most organisms lack cytoplasm. Consequently, most cytoplasmic genetic elements are maternally inherited: they cannot be transmitted patrilinnearly. The evolutionary interests of cytoplasmic elements therefore lie in transmission through the female. These elements may thus be in evolutionary conflict with nuclear genes which are transmitted by both sexes. This conflict is manifested in observations of cytoplasmically induced biased sex‐ratios. Some cytoplasmic genes avoid this fate by biasing the primary sex ratio towards females, or by inducing parthenogenesis. Others (...) kill male hosts, and either achieve transmission via dispersal, or benefit their clonal relatives in the dead male's female siblings. Still others cause the failure of zygotes resulting from pairings between males carrying specific microbes and females lacking them, causing an increase in the microbes through the sterilisation of non‐bearing females. Many, but not all, of these ‘ultra‐selfish’ microbes are closely related. Investigations of the significance of their phylogenetic affinities, or lack of them, their adaptability in terms of the methods by which they avoid, or ameliorate, the adverse effects of being in male hosts, and their importance as selective agents in the evolution of invertebrate sex determination systems, provide fertile spheres for future research. (shrink)

The human genome is not a uniform structure but, instead, is a mosaic of bands. Some of these bands can be seen by the eye. Stained with Giemsa and viewed under the microscope each human chromosome has a prototypical pattern of light and dark bands (G and R bands respectively). Other bands are not so easily viewed. The human genome is, for example, a mosaic of isochores, blocks of DNA within which the proportion of the bases G and C at (...) silent sites (introns, third positions in codons, intergene spacer) is fairly uniform. Recent work by Matassi and colleagues(1) has revealed what might be a new and unexpected banding pattern. They have found that the genes which are close together on the chromosome have similar rates of evolution. BioEssays 22:105–107, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

While it has often been assumed that, in humans, synonymous mutations would have no effect on fitness, let alone cause disease, this position has been questioned over the last decade. There is now considerable evidence that such mutations can, for example, disrupt splicing and interfere with miRNA binding. Two recent publications suggest involvement of additional mechanisms: modification of protein abundance most probably mediated by alteration in mRNA stability1 and modification of protein structure and activity,2 probably mediated by induction of translational (...) pausing. These case histories put a further nail into the coffin of the assumption that synonymous mutations must be neutral. BioEssays 29:515–519, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

In vertebrates it is often found that if one considers a group of genes clustered on a certain chromosome, then the homologues of those genes often form another cluster on a different chromosome. There are four explanations, not necessarily mutually exclusive, to explain how such homologous clusters appeared. Homologous clusters are expected at a low probability even if genes are distributed at random. The duplication of a subset of the genome might create homologous clusters, as would a duplication of the (...) entire genome. Alternatively, it may be adaptive for certain combinations of genes to cluster, although clearly the genes must have duplicated prior to rearrangement into clusters. Molecular phylogenetics provides a means to examine the origins of homologous clusters, although it is difficult to discriminate between the different explanations using current data. However, with more extensive sequencing and mapping of vertebrate genomes, especially those of the early diverging chordates, it should soon become possible to resolve the origins of homologous clusters. BioEssays 21:697–703, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

Remnants of ancient retroviral infections during evolution litter all mammalian genomes. In modern humans, such endogenous retroviral (ERV) sequences comprise at least 8% of the genome. While ERVs and other types of transposable elements undoubtedly contribute to the genomic “junk yard”, functions for some ERV sequences have been demonstrated, with growing evidence that ERVs can be important players in gene regulatory processes. Here we focus on one particular large family of human ERVs, termed HERVH, which several recent studies suggest has (...) a key regulatory role in human pluripotent stem cells. Remarkably, this is not the first instance of an ERV controlling pluripotency. We speculate as to why this convergent evolution might have come about, suggesting that it may reflect selection on the virus to extend the time available for transposition. Alternatively it may reflect serendipity alone. (shrink)

Outlines a tenable version of a traditional foundationalist account\nof empirical justification and its implications for the justification\nof beliefs about physical or material objects. Presupposing the acceptability\nof other beliefs about physical objects; Concept of a basic belief;\nMetabeliefs about one's own occurrent beliefs; Beliefs about sensory\nexperience.

CHAPTER ONE Moral Character and Moral Theories Social interaction is the thread from which the fabric of moral character is woven.1 For it is social ...

Volume 20, Issue 7, July 2020, Page 9-12.

Special relativity has been understood by many as vindicating a tenseless conception of time, denying the existence of tensed facts and a fortiori objective temporal passage. The reason for this is straightforward: both passage and the obtaining of tensed facts require a universal knife-edge present moment—yet this structure is not easily reconcilable with the relativity of simultaneity. The above being said, the prospects for tense and passage are sometimes claimed to be improved on moving to cosmological solutions of general relativity. (...) In this paper, we evaluate in detail these arguments, finding that there remain several open questions to be addressed if the introduction of tensed facts into the relativistic context is to be compelling. Moreover, we argue that, even setting aside these issues, objective tense stands and falls in relativity for exactly the same reasons that it does in classical philosophical discussions on the matter. (shrink)

A syntactically correct number-specification may fail to specify any number due to underspecification. For similar reasons, although each sentence in the Yablo sequence is syntactically perfect, none yields a statement with any truth-value. As is true of all members of the Liar family, the sentences in the Yablo sequence are so constructed that the specification of their truth-conditions is vacuous; the Yablo sentences fail to yield statements. The ‘revenge’ problem is easily defused. The solution to the semantical paradoxes offered here (...) revives the mediaeval cassatio approach, one that largely disappeared due to its incomprehending rejection by influential contemporary writers such as William Shyreswood and Thomas Bradwardine. The diagnosis readily extends to the set-theoretic paradoxes. (shrink)

For Kant right and ethics are two formally distinct departments of a single morality of reason and freedom. Unlike ethics, right involves an authorization to coerce, and this coercion serves as a pathological incentive. I argue that for Kant the distinctive character of right flows from the fact that juridical obligation has a different relational structure than ethical obligation. I argue that this relational structure explains the connection of right to coercion, and also explains how a categorical imperative can be (...) known a priori to issue in both a pathological and non-pathological incentive. Thus the justification of coercion and its special role as incentive are rooted in the relational character of juridical obligations, and so ultimately in categorical imperatives of reason. Since this pathological incentive has a moral basis in the structure of juridical obligations, and so ultimately in a representation of moral laws, I argue that Kant’s discussion of the juridical incentive of coercion is more continuous with his main discussion of moral incentives in the Critique of Practical Reason than it might at first appear. I illustrate the consequences of this reading by discussing the propensity to injustice, as Kant understands it, and the unique way in which the juridical incentive undermines it. (shrink)

John Rawls divides this theory into two parts that he calls ideal and nonideal theory. In this essay I argue that Rawls runs together two quite different conceptions of this dyad corresponding to the idea of strict compliance and realistic utopia respectively. These conceptions employ different criteria of classification, are motivated by different concerns, and have different practical upshots. I present a view that combines the two coherently on Rawls’ behalf while remaining true to his intentions. But I argue that (...) even this amended view is unsatisfactory. Although the realistic utopia conception is well motivated, strict compliance is problematic. The upshot is that we can embrace the division of the theory of justice into ideal and nonideal theory, while rejecting the strict compliance understanding of ideal theory. (shrink)

I argue for the use of the adjunction operator (adding a single new element to an existing set) as a basis for building a finitary set theory. It allows a simplified axiomatization for the first-order theory of hereditarily finite sets based on an induction schema and a rigorous characterization of the primitive recursive set functions. The latter leads to a primitive recursive presentation of arithmetical operations on finite sets.

Over the past thirty-five years, there has been an explosive increase in scientists' ability to explain the structure and functioning of the human brain. While psychology has advanced our understanding of human behavior, various other sciences, such as anatomy, physiology, and biology, have determined the critical importance of synapses and, through the use of advanced technology, made it possible actually to see brain cells at work within the skull's walls. Here Jean-Pierre Changeux elucidates our current knowledge of the human brain, (...) taking an interdisciplinary approach and explaining in layman's terms the complex theories and scientific breakthroughs that have significantly improved our understanding in the twentieth century. (shrink)

Buson, Nardy, Muller & Chevrot (2018) report two experiments ‐ a repetition task and a judgment task ‐ based on the phenomenon of sociolinguistic restoration. When people repeat utterances mixing standard and non‐standard variants, they make them homogeneous. The results suggest that coherent cognitive representation of the sociolinguistic varieties influences the reconstruction of the mixed heard utterance during the repetition. Using the repetition task could help understanding how sociolinguistic cues are organized in memory.

A Sceptical Theory of Scientific Inquiry: Problems and Their Progress presents a distinctive re-interpretation of Popper's 'critical rationalism', displaying the kind of spirit found at the L.S.E. before Popper's retirement. It offers an alternative to interpretations of critical rationalism which have emphasised the significance of research programmes or metaphysics (Lakatos; Nicholas Maxwell), and is closer to the approach of Jagdish Hattiangadi. Briskman gives priority to methodological argument rather than logical formalisms, and takes further his own work on creativity. In addition (...) to offering an important contribution to the understanding of critical rationalism, the book contains interesting engagements with Michael Polanyi and the Meno Paradox. This volume also contains an introduction by the editor, which situates Briskman's work in the history of the interpretation of 'critical rationalism'. (shrink)

Moral concerns about the authority, power, and trustworthiness of physicians have become important topics in clinical ethics during the past three decades. These concerns have come to greater prominence with the increasing involvement of large-scale private institutions in the organization and delivery of medical services, especially managed care organizations, and with the increasing involvement of government in the payment for and organization and delivery of medical services. When physicians act as the agents of large institutions or governments, the power of (...) physicians over their patients increases. The purposes of this article are (1) to reflect briefly on the historical origins of the moral problem of physicians' power in medicine, and (2) to introduce the articles in the 1999 annual number of the Journal of Medicine and Philosophy on topics in clinical ethics. (shrink)

Ce livre complète heureusement les belles études qui ont déjà été menées sur la société de Turin au xviiie siècle. La capitale du Piémont connaît alors une forte croissance démographique en passant d’environ 600 000 habitants vers 1750 à 800 000 à la fin du siècle, mais la crise qui affecte l’économie de la soie et la multiplication des crises de subsistance provoquent un important chômage. L’auteur interroge l’impact de cette conjoncture sur la condition économique des femmes non nobles. Cel...

Madame Legros est une bourgeoise parisienne qui a obtenu en 1784 la libération de Latude, enfermé depuis plus de trente ans dans différentes prisons par des lettres de cachet. Cet article présente son histoire familiale et personnelle avant d’inscrire son action dans une histoire collective des engagements féminins. Il tente une mise en perspective des causes profondes de son engagement par rapport à la lecture qui en a été faite par ses contemporains comme après la Révolution.

In this commentary on Carse and Rushton’s call for reorientation of moral distress, we state agreement with the authors that the discourse of moral distress should refocus on the moral components of integrity. We then explain how our philosophical taxonomy of moral distress, mentioned by the authors, appeals to moral integrity. In this process, we clarify our taxonomy’s appeal to Aristotle’s concept of akrasia. We conclude by offering support of Carse and Rushton’s challenge to organizations to strengthen moral integrity by (...) fostering resilience. (shrink)

This major work by Laurence Lampert provides a new interpretation of modern philosophy by developing Nietzsche's view that genuine philosophers set out to determine the direction of culture through their ideas and that they conceal the radical nature of their thought by their esoteric style. From this Nietzschean perspective, Francis Bacon and René Descartes can be considered the founders of modernity. Lampert argues that Bacon's positive claims for science aimed to destroy the dominance of Christianity. Descartes continued Bacon's radical (...) program while providing it with the mathematical physics required for its success. Far from being solely an epistemological and metaphysical thinker, says Lampert, Descartes was a master writer whose comic ridicule helped bring down the Church to which he paid lip service. Both Bacon and Descartes used the Platonic art of dissimulation to achieve their ends by making their revolutionary aims appear compatible with Christianity. Once we recognize Bacon and Descartes as legislators of modern times in a specifically Nietzschean sense, we can also see Nietzsche in a new way—as the first thinker to have understood modern times and transcended it in a postmodern worldview. According to Lampert, Nietzsche provides a new foundation for culture, a joyous science that reveals the grandeur and purposeless play of the cosmic whole and yet avoids enervating despair or destructive, dogmatic belief. (shrink)

My aim in this paper is to underscore the novelty of Leibniz’s teleology from a historical perspective. I believe this perspective helps deliver a better understanding of the finer details of Leibniz’s employment of final causes. I argue in this paper that Leibniz was taking a stance on three central teleological issues that derive from Aristotle, issues that seem to have occupied nearly every advocate of final causes from Aristotle to Leibniz. I discuss the three Aristotelian issues, and how major (...) thinkers treated them in the medieval period. I argue that Leibniz rejected all of the mainstream Aristotelian teleological views on these issues. I conclude that Leibniz broke with longstanding threads of teleological thinking in ways that were often extreme. (shrink)

One objection to xenotransplantation is that it will require the large-scale breeding, raising and killing of genetically modified pigs. The pigs will need to be raised in designated pathogen-free facilities and undergo a range of medical tests before having their organs removed and being euthanised. As a result, they will have significantly shortened life expectancies, will experience pain and suffering and be subject to a degree of social and environmental deprivation. To minimise the impact of these factors, we propose the (...) following option for consideration—ethically defensible xenotransplantation should entail the use of genetic disenhancementifit becomes possible to do so and if that pain and suffering cannot be eliminated by other means. Despite not being a morally ideal ‘solution’, itismorally better to prevent unavoidable pain until a viable non-animal alternative becomes available. (shrink)

Kolbe and de Melo-Martin’s (2023) arguments draw attention to what is most useful about moral distress—identifying its causes is at least as important as measuring its severity. Jameton’s original...

Nipah virus is a priority pathogen that is receiving increasing attention among scientists and in work on epidemic preparedness. Despite this trend, there has been almost no bioethical work examining ethical considerations surrounding the epidemiology, prevention, and treatment of Nipah virus or research that has already begun into animal and human vaccines. In this paper, we advance the case for further work on Nipah virus disease in public health ethics due to the distinct issues it raises concerning communication about the (...) modes of transmission, the burdens of public health surveillance, the recent use of stringent public health measures during epidemics, and social or religious norms intersecting with preventive measures. We also advance the case for further work on Nipah virus disease in research ethics, given ethical issues surrounding potential vaccine trials for a high-fatality disease with sporadic spillover events, the different local contexts where trials may occur, and the potential use of unproven therapeutics during outbreaks. Further bioethics work may help to ensure that research and public health interventions for Nipah virus disease are ethically acceptable and more likely to be effective. (shrink)