Recent studies uncovered critical roles of the adhesion protein E‐cadherin in health and disease. Global inactivation of Cdh1, the gene encoding E‐cadherin in mice, results in early embryonic lethality due to an inability to form the trophectodermal epithelium. To unravel E‐cadherin's functions beyond development, numerous mouse lines with tissue‐specific disruption of Cdh1 have been generated. The consequences of E‐cadherin loss showed great variability depending on the tissue in question, ranging from nearly undetectable changes to a complete loss of tissue structure (...) and function. This review focuses on these studies and discusses how they provided important insights into E‐cadherin's role in cell adhesion, proliferation and differentiation, and its consequences for biological processes as epithelial‐to‐mesenchymal transition, vascularization, and carcinogenesis. Lastly, we present some perspectives and possible approaches for future research. (shrink)

Das Leben ist ein fundamentales Phänomen unserer Welt. In der Theologie war das Leben immer schon eine zentrale Größe, eng verbunden mit dem Schöpfungshandeln Gottes. Für die Philosophie ist es eine bleibende Herausforderung, das Leben begrifflich zu fassen. In der Ausdifferenzierung der modernen Wissenschaften gibt es einen eigenen Wissenschaftszweig, den der Biologie, der sich mit den vielfältigen Formen des Lebens beschäftigt. Doch ist nach wie vor unbekannt, wie Leben überhaupt entstehen konnte. Die Beiträge dieses Buches widmen sich dem Lebensbegriff und (...) gehen seiner Bedeutungsvielfalt und Rätselhaftigkeit nach: Wie nähern sich die unterschiedlichen Disziplinen heute dem Leben? Welches Verhältnis hat das Leben zu fundamentalen Werten? Gibt es einen Zusammenhang zwischen dem Leben und der Zeit oder zwischen dem Leben und dem Bewusstsein? (shrink)

We report on the small-scale (0.5 13 h - 1M, a large-scale bias of ~2.0 and a satellite fraction of 12 ± 2 per cent. Thus, these galaxies occupy haloes with average masses in between those of the higher redshift BOSS CMASS sample and the original SDSS I/II luminous red galaxy sample © 2012 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society © doi:10.1093/mnras/sts314.

Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer’s disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults from the DZNE-Longitudinal Cognitive Impairment and Dementia Study study. Participants reporting having played a musical instrument across three life periods were compared to controls without a history of musical instrument playing, well-matched for reserve proxies of education, (...) intelligence, socioeconomic status and physical activity. Participants with musical activity outperformed controls in global cognition, working memory, executive functions, language, and visuospatial abilities, with no effects seen for learning and memory. The musically active group had greater gray matter volume in the somatosensory area, but did not differ from controls in higher-order frontal, temporal, or hippocampal volumes. However, the association between gray matter volume in distributed frontal-to-temporal regions and cognitive abilities was enhanced in participants with musical activity compared to controls. We show that playing a musical instrument during life relates to better late-life cognitive abilities and greater brain capacities in OA. Musical activity may serve as a multimodal enrichment strategy that could help preserve cognitive and brain health in late life. Longitudinal and interventional studies are needed to support this notion. (shrink)

In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick Ferré. These essays, informed by the insights of Ferré and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.

In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick FerrZ. These essays, informed by the insights of FerrZ and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.

Die historische Aufklärung hat eine Reihe ihrer wichtigsten Leitgedanken im Feld der Praktischen Philosophie entwickelt. Aus der Orientierung an der Praxis erwuchsen Veränderungen, die das überkommene System der Wissenschaften und das Gefüge der gesellschaftlichen Institutionen ebenso betrafen wie die Formen der Kommunikation und nicht zuletzt die Regeln der individuellen Lebensführung. Der vorliegende Band versucht im Ausgang von Einzelanalysen und aus der Eigenperspektive der Epoche wichtige Grundzüge des denkgeschichtlichen und kulturellen Wandels zu beschreiben, um der Frage nach den Wirkungen der aufklärerischen (...) Praxislehren eine historische Grundlage zu geben. (shrink)

In this paper, I consider the relationship between Inference to the Best Explanation and Bayesianism, both of which are well-known accounts of the nature of scientific inference. In Sect. 2, I give a brief overview of Bayesianism and IBE. In Sect. 3, I argue that IBE in its most prominently defended forms is difficult to reconcile with Bayesianism because not all of the items that feature on popular lists of “explanatory virtues”—by means of which IBE ranks competing explanations—have confirmational import. (...) Rather, some of the items that feature on these lists are “informational virtues”—properties that do not make a hypothesis \ more probable than some competitor \ given evidence E, but that, roughly-speaking, give that hypothesis greater informative content. In Sect. 4, I consider as a response to my argument a recent version of compatibilism which argues that IBE can provide further normative constraints on the objectively correct probability function. I argue that this response does not succeed, owing to the difficulty of defending with any generality such further normative constraints. Lastly, in Sect. 5, I propose that IBE should be regarded, not as a theory of scientific inference, but rather as a theory of when we ought to “accept” H, where the acceptability of H is fixed by the goals of science and concerns whether H is worthy of commitment as research program. In this way, IBE and Bayesianism, as I will show, can be made compatible, and thus the Bayesian and the proponent of IBE can be friends. (shrink)

John Dewey and the spirit of pragmatism, by H. M. Kallen.--Dewey and art, by I. Edman.--Instrumantalism and the history of philosophy, by G. Boas.--Culture and personality, by L. K. Frank.--Social inquiry and social doctrine, by H. L. Friess.--Dewey's theories of legal reasoning and valuation, by S. Ratner.--John Dewey and education, by J. L. Childs.--Dewey's revision of Jefferson, by M. R. Konvitz.--Laity and prelacy in American democracy, by H. W. Schneider.--Organized labor and the Dewey philosophy, by M. Starr.--The desirable and (...) emotive in Dewey's ethics, by S. Hook.--John Dewey's theory of inquiry, by F. Kaufman.--Dewey's theory of natural science, by E. Nagel.--Concerning a certain Deweyan conception of metaphysics, by A. Hofstadter.--Dewey's theory of language and meaning, by P. D. Wienpahl.--Language, rules, and behavior, by W. Sellars.--The analytic and the synthetic: an untenable dualism, by M. G. White.--John Dewey and Karl Marx, by J. Cork.--Dewey in Mexico, by J. T. Farrell. (shrink)

Translates an important 1932 work by Austrian physicist-turned- philosopher Frank (1884-1966). Among the topics he discusses are the Laplacean determinism of global causal laws of nature; the loss of causal simplicity with the establishment of field concepts; cause and chance in classical, statistical-mechanical, and quantum physics; conservation in laws and causal laws; the seeming irreversibility of natural processes; extremal principles; vitalist explanations as also causal; miracles and theological explanations; and lawfulness in the phenomena of life. First published by Springer-Verlag (...) as Das Kauselgesetz und seine Grenzen. No subject index. Annotation copyrighted by Book News, Inc., Portland, OR. (shrink)

Contains the following contributions: -/- Ingvar Johansson: Ontologies and Concepts. Two Proposals -/- Christopher Menzel: Reference Ontologies - Application Ontologies: Either/Or or Both/And? -/- Luc Schneider: Foundational Ontologies and the Realist Bias -/- Guenther Goerz, Kerstin Buecher, Bernd Ludwig, Frank-Peter Schweinberger, and Iman Thabet: Combining a Lexical Taxonomy with Domain Ontology in the Erlangen Dialogue System -/- Vim Vandenberghe, Burkhard Schafer, John Kingston: Ontology Modelling in the Legal Domain - Realism Without Revisionism -/- A Proposed Methodology for the Development (...) of Application-Based Formal Ontologies Eric Little . (shrink)

El vídeo fue considerado por Gene Youngblood (1979) como un nuevo medio de creación artística, cuyos códigos abrirán nuevas perspectivas a la imagen en movimiento dándole entidad estética propia. Se analiza diversas teorías relacionadas con la comunicación y el arte de autores como Wiener, Benjamin, Brecht, McLuhan, Burris. Así mismo estudia obras pioneras y el uso del feedback loop como elemento de retroalimentación entre emisor receptor. Wipe Cycle (1969) de Frank Gillette e Ira Schneider y Time Delay Room (1974) (...) de Dan Graham nos mostrarán las claves para entender el funcionamiento interno de un nuevo medio que acababa de nacer. (shrink)

Die Beitrage des Sammelbandes widmen sich aus theologisch-philosophischer Perspektive der historischen Rezeption und der systematischen Relevanz des Freiheitsstreits zwischen Martin Luther und Erasmus von Rotterdam. Im systematischen Zentrum steht das jeweilige freiheitstheoretische Verstandnis des Menschen, seiner epistemischen und voluntativen Vermogen und seines metaphysischen Ortes innerhalb der Schopfung, besonders sein Verhaltnis zu Gott. Aus historischer Perspektive wird die Rezeption von Luthers Freiheitsbegriff durch Leibniz, Kant, Hegel, Schelling und in der analytischen Philosophie untersucht. Mit Beitragen von Christine Axt-Piscalar, Frank Dettinger, Thomas (...) Frisch, Volker Gerhardt, Friedrich Hermanni, Amit Kravitz, Jorg Noller, Wolfhart Pannenberg, Birgit Recki, Georg Sans SJ, Ruben Schneider und Gunther Wenz. (shrink)

This chapter focuses on AI-based cognitive and perceptual enhancements. AI-based brain enhancements are already under development, and they may become commonplace over the next 30–50 years. We raise doubts concerning whether radical AI-based enhancements transhumanists advocate will accomplish the transhumanists goals of longevity, human flourishing, and intelligence enhancement. We urge that even if the technologies are medically safe and are not used as tools by surveillance capitalism or an authoritarian dictatorship, these enhancements may still fail to do their job for (...) philosophical reasons. In what follows, we explore one such concern, a problem that involves the nature of the self. We illustrate that the so called transhumanist efforts to “merge oneself with AI” could lead to perverse realizations of AI technology, such as the demise of the person who sought enhancement. And, in a positive vein, we offer ways to avoid this, at least within the context of one theory of the nature of personhood. (shrink)

Recent experiments in moral psychology have been taken to imply that moral reasoning only serves to reaffirm prior moral intuitions. More specifically, Jonathan Haidt concludes from his moral dumbfounding experiments, in which people condemn other people’s behavior, that moral reasoning is biased and ineffective, as it rarely makes people change their mind. I present complementary evidence pertaining to self-directed reasoning about what to do. More specifically, Albert Bandura’s experiments concerning moral disengagement reveal that moral reasoning often does contribute effectively to (...) the formation of moral judgments. And such reasoning need not be biased. Once this evidence is taken into account, it becomes clear that both cognition and affect can play a destructive as well as a constructive role in the formation of moral judgments. (shrink)

The rule of law is a valuable human achievement. It is valuable not only instrumentally, but also for its own sake as a significant aspect of social justice. Only in a society that enjoys the rule of law is it possible for people to regard one another as fellow free citizens; no one the master of anyone else. Nevertheless, the rule of law is poorly understood. In this book, Frank Lovett develops a rigorous conception of the rule of law (...) that is grounded in legal positivism, and offers a civic republican argument for its value in terms of freedom from domination. Bridging persistent methodological gaps that divide legal philosophy, social science, and political theory, Lovett demonstrates how insights from all three can be united in a single powerful theory. This book will appeal to anyone interested in the rule of law, including scholars, legal officials, and policy-makers. (shrink)