Recent studies uncovered critical roles of the adhesion protein E‐cadherin in health and disease. Global inactivation of Cdh1, the gene encoding E‐cadherin in mice, results in early embryonic lethality due to an inability to form the trophectodermal epithelium. To unravel E‐cadherin's functions beyond development, numerous mouse lines with tissue‐specific disruption of Cdh1 have been generated. The consequences of E‐cadherin loss showed great variability depending on the tissue in question, ranging from nearly undetectable changes to a complete loss of tissue structure (...) and function. This review focuses on these studies and discusses how they provided important insights into E‐cadherin's role in cell adhesion, proliferation and differentiation, and its consequences for biological processes as epithelial‐to‐mesenchymal transition, vascularization, and carcinogenesis. Lastly, we present some perspectives and possible approaches for future research. (shrink)

Das Leben ist ein fundamentales Phänomen unserer Welt. In der Theologie war das Leben immer schon eine zentrale Größe, eng verbunden mit dem Schöpfungshandeln Gottes. Für die Philosophie ist es eine bleibende Herausforderung, das Leben begrifflich zu fassen. In der Ausdifferenzierung der modernen Wissenschaften gibt es einen eigenen Wissenschaftszweig, den der Biologie, der sich mit den vielfältigen Formen des Lebens beschäftigt. Doch ist nach wie vor unbekannt, wie Leben überhaupt entstehen konnte. Die Beiträge dieses Buches widmen sich dem Lebensbegriff und (...) gehen seiner Bedeutungsvielfalt und Rätselhaftigkeit nach: Wie nähern sich die unterschiedlichen Disziplinen heute dem Leben? Welches Verhältnis hat das Leben zu fundamentalen Werten? Gibt es einen Zusammenhang zwischen dem Leben und der Zeit oder zwischen dem Leben und dem Bewusstsein? (shrink)

In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick Ferré. These essays, informed by the insights of Ferré and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.

Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer’s disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults from the DZNE-Longitudinal Cognitive Impairment and Dementia Study study. Participants reporting having played a musical instrument across three life periods were compared to controls without a history of musical instrument playing, well-matched for reserve proxies of education, (...) intelligence, socioeconomic status and physical activity. Participants with musical activity outperformed controls in global cognition, working memory, executive functions, language, and visuospatial abilities, with no effects seen for learning and memory. The musically active group had greater gray matter volume in the somatosensory area, but did not differ from controls in higher-order frontal, temporal, or hippocampal volumes. However, the association between gray matter volume in distributed frontal-to-temporal regions and cognitive abilities was enhanced in participants with musical activity compared to controls. We show that playing a musical instrument during life relates to better late-life cognitive abilities and greater brain capacities in OA. Musical activity may serve as a multimodal enrichment strategy that could help preserve cognitive and brain health in late life. Longitudinal and interventional studies are needed to support this notion. (shrink)

In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick FerrZ. These essays, informed by the insights of FerrZ and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.

We report on the small-scale (0.5 13 h - 1M, a large-scale bias of ~2.0 and a satellite fraction of 12 ± 2 per cent. Thus, these galaxies occupy haloes with average masses in between those of the higher redshift BOSS CMASS sample and the original SDSS I/II luminous red galaxy sample © 2012 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society © doi:10.1093/mnras/sts314.

Die historische Aufklärung hat eine Reihe ihrer wichtigsten Leitgedanken im Feld der Praktischen Philosophie entwickelt. Aus der Orientierung an der Praxis erwuchsen Veränderungen, die das überkommene System der Wissenschaften und das Gefüge der gesellschaftlichen Institutionen ebenso betrafen wie die Formen der Kommunikation und nicht zuletzt die Regeln der individuellen Lebensführung. Der vorliegende Band versucht im Ausgang von Einzelanalysen und aus der Eigenperspektive der Epoche wichtige Grundzüge des denkgeschichtlichen und kulturellen Wandels zu beschreiben, um der Frage nach den Wirkungen der aufklärerischen (...) Praxislehren eine historische Grundlage zu geben. (shrink)

El vídeo fue considerado por Gene Youngblood (1979) como un nuevo medio de creación artística, cuyos códigos abrirán nuevas perspectivas a la imagen en movimiento dándole entidad estética propia. Se analiza diversas teorías relacionadas con la comunicación y el arte de autores como Wiener, Benjamin, Brecht, McLuhan, Burris. Así mismo estudia obras pioneras y el uso del feedback loop como elemento de retroalimentación entre emisor receptor. Wipe Cycle (1969) de Frank Gillette e Ira Schneider y Time Delay Room (1974) (...) de Dan Graham nos mostrarán las claves para entender el funcionamiento interno de un nuevo medio que acababa de nacer. (shrink)

English summary: Is radical self-determination relevant to the theory of freedom? In other words, is it a constitutive moment of freedom? And is radical self-determination possible or indeed real? Frank Dettinger understands radical self-determination as being the faculty of an acting subject - in whose personal and characteristic nature decisions and actions are established - to self-determine in an independent act. The author provides impetus not only for the analytical-philosophical, but also the theological freedom debates. In the first instance, (...) his work is intended as a contribution to the understanding of the freedom debate about itself. Secondly, its objective seeks to demonstrate the potential of an inter-disciplinary approach. The author reconstructs Luther's understanding of freedom by the precise application of analytical-philosophical freedom systematics and in this way makes it accessible to argumentative examination. German description: Ist radikale Selbstbestimmung freiheitstheoretisch relevant, d.h. ein konstitutives Moment von Freiheit? Und ist radikale Selbstbestimmung moglich oder gar wirklich? Unter radikaler Selbstbestimmung versteht Frank Dettinger dabei das Vermogen eines Handlungssubjekts, dessen personliche und charakterliche Beschaffenheit, in der seine Entscheidungen und Handlungen grunden, in einem unabhangigen Akt selbst zu bestimmen.Dettinger gibt Impulse sowohl fur die analytisch-philosophische als auch fur die theologische Freiheitsdebatte. In der ersten Hinsicht versteht sich seine Arbeit insbesondere als Beitrag zur Verstandigung der Freiheitsdebatte uber sich selbst. In der zweiten Hinsicht liegt das Proprium im Aufweis des Potentials eines interdisziplinaren Vorgehens. Er rekonstruiert Luthers Freiheitsverstandnis in Anwendung analytisch-philosophischer Freiheitssystematik prazise und macht es auf diese Weise einer argumentativen Prufung zuganglich. (shrink)

How important is luck in economic success? No question more reliably divides conservatives from liberals. As conservatives correctly observe, people who amass great fortunes are almost always talented and hardworking. But liberals are also correct to note that countless others have those same qualities yet never earn much. In recent years, social scientists have discovered that chance plays a much larger role in important life outcomes than most people imagine. In Success and Luck, bestselling author and New York Times economics (...) columnist Robert Frank explores the surprising implications of those findings to show why the rich underestimate the importance of luck in success--and why that hurts everyone, even the wealthy. Frank describes how, in a world increasingly dominated by winner-take-all markets, chance opportunities and trivial initial advantages often translate into much larger ones--and enormous income differences--over time; how false beliefs about luck persist, despite compelling evidence against them; and how myths about personal success and luck shape individual and political choices in harmful ways. But, Frank argues, we could decrease the inequality driven by sheer luck by adopting simple, unintrusive policies that would free up trillions of dollars each year--more than enough to fix our crumbling infrastructure, expand healthcare coverage, fight global warming, and reduce poverty, all without requiring painful sacrifices from anyone. If this sounds implausible, you'll be surprised to discover that the solution requires only a few, uncontroversial steps. Compellingly readable, Success and Luck shows how a more accurate understanding of the role of chance in life could lead to better, richer, and fairer economies and societies. (shrink)

Meaningful work is a key element of positive functioning of employees, but what makes work meaningful? Based on research on self-determination theory, basic psychological needs, and prosocial impact, we suggest that there are four psychological satisfactions that substantially influence work meaningfulness across cultures: autonomy (sense of volition), competence (sense of efficacy), relatedness (sense of caring relationships), and beneficence (sense of making a positive contribution). We test the relationships between these satisfactions and perceived meaningful work in Finland (n = 594, employees (...) of several organizations), India (n = 342, collected through Mturk), and the USA (n = 373, collected through Mturk). Regression analyses show that – except for competence in USA – all four satisfactions are significantly and independently associated with meaningful work. Moreover, structural equation modeling shows that they fully mediated the relationship between occupational position and work meaningfulness in India and in the USA. In sum, the results support the importance of these four satisfactions in explaining the psychological underpinnings of meaningful work. (shrink)

This paper explores the consequences of applying two natural ideas from epistemology to decision theory: (1) that knowledge should guide our actions, and (2) that we know a lot of non-trivial things. In particular, we explore the consequences of these ideas as they are applied to standard decision theoretic puzzles such as the St. Petersburg Paradox. In doing so, we develop a “knowledge-first” decision theory and we will see how it can help us avoid fanaticism with regard to the St. (...) Petersburg puzzle and related puzzles. The result will be a decision theory that gives a novel, but well-motivated, reason for discounting small probabilities when making decisions. We examine the merits and demerits of such a decision theory. (shrink)

Zusammenfassung Die im Dezember 2022 in Kraft getretene Erweiterung des Infektionsschutzgesetzes sieht vor, im Fall einer Pandemie knappe intensivmedizinische Ressourcen nach dem Kriterium der Überlebenswahrscheinlichkeit zu priorisieren. Der Aufsatz geht der Frage nach, ob der Vorwurf, diese Regelung setze Menschen mit Behinderung einer erheblichen Diskriminierungsgefahr aus, berechtigt ist. Nach einer kurzen Darstellung des im Infektionsschutzgesetz festgelegten Zuteilungsverfahrens wird zunächst das vielschichtige Konzept der Diskriminierung erörtert. Im Kontext der Allokation knapper intensivmedizinischer Ressourcen besteht vornehmlich das Risiko einer nichtintendierten Diskriminierung, die in (...) direkter wie auch indirekter Form erfolgen kann. Die Regelungen, die das Infektionsschutzgesetz trifft, bieten Menschen mit Behinderung einen vergleichsweise hohen Schutz vor direkter Diskriminierung. Dennoch müssen Menschen mit bestimmten Behinderungen gravierende Nachteile hinnehmen, weil sie im Fall einer COVID-19-Infektion absehbar eine geringere Überlebenswahrscheinlichkeit als gesunde Menschen haben. Eine indirekte Diskriminierung liegt aber nur dann vor, wenn für die Auferlegung disproportionaler Nachteile keine hinreichende Rechtfertigung angeführt werden kann. In modernen pluralistischen Gesellschaften, die durch tiefgreifende Wertkonflikte gekennzeichnet sind, sollten unterschiedliche ethische Theorien – darunter auch konsequentialistische Positionen – als mögliche Grundlage einer Rechtfertigung anerkannt werden. Im Ergebnis erweist sich der Vorwurf, eine am Kriterium der Überlebenswahrscheinlichkeit orientierte Zuteilung knapper intensivmedizinischer Ressourcen bewirke eine Diskriminierung von Menschen mit Behinderung, als nicht stichhaltig. (shrink)

ABSTARCT When people go shopping, they enter a building. But the shop cannot be identified with the building, because it would remain the same shop if it moved to another building or if it became an e-store. Daniel Korman [2019] uses these two observations to argue that establishments are immaterial objects. However, all that follows is that establishments are not buildings. I argue that establishments are organisations or corporate agents that are constituted by people. This entails that they are material (...) objects. Korman’s observations can be accommodated in terms of the further observation that corporate agents can but need not own or rent buildings. (shrink)

In this chapter we take stock of some of the complexities of the sprawling field of AI ethics. We consider questions like "what is the proper scope of AI ethics?" And "who counts as an AI ethicist?" At the same time, we flag several potential uses and abuses of AI ethics. These include challenges for the AI ethicist, including what qualifications they should have; the proper place and extent of futuring and speculation in the field; and the dilemmas concerning how (...) we use our public and academic resources. (shrink)

Die Beitrage des Sammelbandes widmen sich aus theologisch-philosophischer Perspektive der historischen Rezeption und der systematischen Relevanz des Freiheitsstreits zwischen Martin Luther und Erasmus von Rotterdam. Im systematischen Zentrum steht das jeweilige freiheitstheoretische Verstandnis des Menschen, seiner epistemischen und voluntativen Vermogen und seines metaphysischen Ortes innerhalb der Schopfung, besonders sein Verhaltnis zu Gott. Aus historischer Perspektive wird die Rezeption von Luthers Freiheitsbegriff durch Leibniz, Kant, Hegel, Schelling und in der analytischen Philosophie untersucht. Mit Beitragen von Christine Axt-Piscalar, Frank Dettinger, Thomas (...) Frisch, Volker Gerhardt, Friedrich Hermanni, Amit Kravitz, Jorg Noller, Wolfhart Pannenberg, Birgit Recki, Georg Sans SJ, Ruben Schneider und Gunther Wenz. (shrink)

Peterson et al. (2023) identify important ethical issues that are relevant to psychedelic therapy and research in various clinical populations and contexts. This is certainly the case in palliative...

The restructuration of municipalities which has been decided by the Belgian government, is not only a purely technical operatzon but rather, and in the first place, a social problem. The shape and duty-profile of a local authority should not, indeed, be attuned only to fast changing expectations as far as services are concerned, but to consultation and participation as well.Public administration research cannot keep aloof from this debate, but is considerably hampered by the institutional confusion and the insufficient explicitation of (...) the aims of the present reform. A starting-pointcan, however, be found in the mergers of municipalities that were realized in 1964 and in 1970/1971. In 67 of these municipalities an inquiry was held concerning the consequences of the merger, and moreover, in twotest-cases this inquiry grew to a full-scale systematic policy analysis.This research shows that, as a rule, the former municipalities are reasonably represented in the new entity's council, but it also reveals that few efforts are made to give this representation a broader impact along formal or informal participation-channels. Integration of employees has not caused insurmountable problems. However, in large sized municipalities, resulting from mergers, one could notice a drastic increase in municipal personnel, not only with regard to new duties and objectives but to traditional administrative and police duties as well. Such a phenomenon points to the far-reaching changes which a substantial scale-increase provokes in a municipality's structure and policy profile. A large municipality resulting from mergers is no langer a simple sum of component parts, but a completely new entity, wishing to catch up as fast as possible with comparable municipalities that passed through a progressive growth process. Therefore, scale-increase is not only a means of economizing or an intra-administrative matter, but rather a way of creating chances for further development or wealth and well-being. (shrink)

This volume analyses, from a computational point of view, how culture may arise, develop and evolve through time. The four sections in this book examine and analyse the modelling of culture, group and organisation culture, culture simulation, and culture-sensitive technology design. Different research disciplines have different perspectives on culture, making it difficult to compare and integrate different concepts and models of culture. By taking a computational perspective this book nevertheless enables the integration of concepts that play a role in culture, (...) even though they might originate from different disciplines. Culture is usually regarded as something vague and qualitative and thus difficult to deal with in a computational and formal setting. Taking a computational approach to culture thus encompasses a twofold risk: taking a too simplistic approach to cultural influence on behaviour; or trying to capture too much, hence not leading to useful computational tools. However, the approaches and insights in this collection show how different perspectives by leading researchers described in thirteen chapters still can form a coherent picture. The book thus illustrates the potential of using computing systems to better understand culture. By describing methods, theories and concrete application results about the integration of cultural aspects into computer systems, this book provides inspiration to researchers of all disciplines alike and presents the start of an interdisciplinary dialogue on culture. (shrink)

John Dewey's Experience and Education is an important book, but first-time readers of Dewey's philosophy can find it challenging and not meaningfully related to the contemporary landscape of education. Jeff Frank's Teaching in the Now aims to reanimate Dewey's text--for first-time readers and anyone who teaches the text or is interested in appreciating Dewey's continuing significance--by focusing on Dewey's thinking on preparation. Frank, through close readings of Dewey, asks readers to wonder: How much of what we justify as (...) preparation in education is actually necessary? That is, every time we catch ourselves telling a student--you need to learn this in order to do something else--we need to stop and reflect. We need to reflect, because when we always justify the present moment of a student's education in terms of what will happen in the future, we may lose out on the ability to engage students' attention and interest now, when it matters. Dewey asks his readers to trust that the best way to prepare students for an engaging and productive future is to create the most engaging and productive present experience for students. We learn to live fully in the future, only by practicing living fully in the present. Although it can feel scary to stop thinking of the work of education in terms of preparation, when educators reclaim the present for students, new opportunities--for teachers, students, schools, democracy, and education--emerge. Teaching in the Now explores these opportunities in impassioned and engaging prose that makes Experience and Education come alive for readers new to Dewey or who have taught and read him for many years. (shrink)

A main goal of this paper is to complicate “learning loss” as the only, or even the main, thing schools should be concerned about as they respond to the Covid-19 pandemic. While schools have a responsibility to make sure students who are enrolled in school are learning, this cannot come at the cost of ignoring the other substantial losses students are also contending with. Following the work of Jonathan Lear, I make the case that schools should engage students in a (...) process of learning how to mourn for their individual and our collective losses, while also considering ways that school can move beyond narrow conceptions of the purposes of school and to a deeper appreciation for the ways that an education can promote human excellence. As this pandemic wears on, it becomes harder and harder to do anything but endure. One goal of this paper is to serve as a reminder that schools can do more than endure: they can envision new possibilities for schooling that promote conceptions of wellbeing that go beyond fear of learning loss. (shrink)

This paper will critically engage with Daniel Buckley's argument against “evidential minimalism” (EM), i.e., the claim that necessarily, bits of evidence (are or) provide epistemic reasons for belief. Buckley argues that in some cases, a subject has strong evidence that p (and fulfills further minimal conditions), does not believe p, but nevertheless is not epistemically criticizable and has no epistemic reason to believe p. I will defend EM by pointing out that Buckley's argument trades on an ambiguity between a strong (...) and a weak notion of criticizability. (shrink)

In this chapter we identify three potentially morally problematic behaviours that are common among users of dating and hook-up apps (DHAs) and provide arguments as to why they may or may not be considered (a) in a category of their own, distinct from similar behaviours outside of DHAs; (b) caused or facilitated by affordances and business logic of DHAs; (c) as indeed morally wrong. We also consider ways in which morally problematic behaviours can be anticipated, mitigated, or even prevented by (...) analysis of the ethical and moral dimensions of technologies and their afforded uses. Finally, we offer some possible directions for future work on these topics in particular and on the ethical consequences of DHAs in general. (shrink)

The once-lost introduction to the philosophy of science by Philipp Frank (1884-1966), a leading member of the Vienna circle of philosophers and biographer of Albert Einstein.

Algorithmic decision-making increasingly shapes people's daily lives. Given that such autonomous systems can cause severe harm to individuals and social groups, fairness concerns have arisen. A human-centric approach demanded by scholars and policymakers requires considering people's fairness perceptions when designing and implementing algorithmic decision-making. We provide a comprehensive, systematic literature review synthesizing the existing empirical insights on perceptions of algorithmic fairness from 58 empirical studies spanning multiple domains and scientific disciplines. Through thorough coding, we systemize the current empirical literature along (...) four dimensions: (1) algorithmic predictors, (2) human predictors, (3) comparative effects (human decision-making vs. algorithmic decision-making), and (4) consequences of algorithmic decision-making. While we identify much heterogeneity around the theoretical concepts and empirical measurements of algorithmic fairness, the insights come almost exclusively from Western-democratic contexts. By advocating for more interdisciplinary research adopting a society-in-the-loop framework, we hope our work will contribute to fairer and more responsible algorithmic decision-making. (shrink)

This paper pursues three goals: First, to develop a lateral reading of Camus’ Stranger. A lateral reading is characterized by the displacement of the central conflict. In the case of The Stranger, I argue that the central conflict in the novel lies in the relation between the author and the protagonist, not, as direct readings would have it, in the relation between the protagonist and his predicament. Second, to spell out more precisely why it should be read as an anti-existentialist (...) novel. Here I argue that a lateral reading shows that the foundational existentialist opposition between telling and living is ironically dismantled by the very lateral structure of the novel. Third, to develop the notion of a lateral reading with a view to its potential advantages. Here, I point out that literalism involves positionalism and dynamicism. Positionalism refers to the reduction of fictional entities to their role in relation to each other. Dynamicism refers to the resulting view that those roles are further reducible to forces. I conclude that the lateral reading, with its commitments to positionalism and dynamicism is a model generalizable to the analysis of other fictional works. (shrink)

Ratio, Volume 34, Issue 4, Page 277-285, December 2021.

In his recent book Shared and Institutional Agency, Bratman (2022) argues that institutional agents consist of social rules of procedure. Those rules are policies that are shared among many of their members. In this review essay, I argue that the theory can plausibly be interpreted in terms of ontological holism. It shows how a holistic theory can be constructed out of individualistic building blocks. At the same time, Bratman rejects mental holism, the idea being that institutional agents form only a (...) limited range of mental states. Furthermore, he claims that they can perform actions literally for no reason. I propose that, if this is indeed possible, a morally accountable agent will avoid doing so. (shrink)

This article argues in favour of a formal definition of fanaticism as a certain relationship to one’s beliefs that is informed by the assumption that there is a mutual incompatibility between consistency and moderation. It analyses this assumption as an expression of an implicit commitment to naïve realism. It then proposes a critique of such realism and finally it sketches an ontological alternative, able to philosophically and politically respond to and oppose fanaticism by showing the compossibility, on that ontological view, (...) of moderation and consistency. (shrink)