Results for ' Hyperbaric oxygen treatment'

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  1.  14
    Brain and Mind Integration: Childhood Sexual Abuse Survivors Experiencing Hyperbaric Oxygen Treatment and Psychotherapy Concurrently.Rachel Lev-Wiesel, Yair Bechor, Shir Daphna-Tekoah, Amir Hadanny & Shai Efrati - 2018 - Frontiers in Psychology 9.
    Due to evidence that traumatic experience impacts the brain, the body (concerning sensory sensitivity), and the mind, a recent study that attempted to answer the question of whether the effects of CSA can be reversed by using a multidisciplinary approach consisting of dual treatments: hyperbaric & psychotherapy, was conducted. Its results showed that in addition to improvement of brain functionality, symptoms of distress were significantly reduced. The current paper aims to present the process as experienced by the 40 female (...)
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  2.  57
    The Effect of Hemoglobin Concentration on Hyperbaric Oxygen and Non-hyperbaric Oxygen in the Treatment of Hypertensive Intracerebral Hemorrhage After Operation at the High Altitude.Linjie Wei, Chi Lin, Xingsen Xue, Shiju Jila, Yalan Dai, Li Pan, Wei Wei, Guodong Dun, Yong Shen, Taoxi Zong, Jingjing Wu, Yafang Li, Lixia Wu, Jishu Xian & Anyong Yu - 2022 - Frontiers in Human Neuroscience 16.
    BackgroundThe prognosis of hypertensive intracerebral hemorrhage is poor at high altitudes. The objective of this study was to explore whether hyperbaric oxygen can improve the results of computed tomography perfusion imaging and the neurological function of patients with HICH, and influence the hemoglobin concentration.MethodThe patients with HICH were treated with puncture and drainage. Twenty-one patients were treated with HBO after the operation, and the other patients received conventional treatment. CTP was performed twice, and all indices were measured. (...)
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  3.  4
    Hypothesis: Drainage of the peripheral tissue edema by the hyperbaric oxygen therapy because of hyperoxygenation that constricts arterioles and alters the downstream capillary fluid traffic in affected tissues.Sven Kurbel, Vid Ćurković & Borna Kovačić - 2023 - Bioessays 45 (6):2300023.
    Hyperbaric oxygen (HBO) therapy still lacks proper interpretations of its many actions. This hypothesis is based on reports of temporarily elevated peripheral vascular resistance (PVR) during HBO sessions. Besides that, during HBO sessions, hyperoxygenated tissues can reduce their perfusion so much that CO2 can accumulate in them. Tissue perfusion depends on vascular innervation and on the balance between systemic constrictors and local dilators. During an HBO session, increased tissue oxygen levels suppress dilatory mechanisms. Tissue hyperoxygenation increases PVR, (...)
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  4.  9
    Hyperbaric Oxygen Therapy Can Induce Neuroplasticity and Significant Clinical Improvement in Patients Suffering From Fibromyalgia With a History of Childhood Sexual Abuse—Randomized Controlled Trial.Amir Hadanny, Yair Bechor, Merav Catalogna, Shir Daphna–Tekoah, Tal Sigal, Mehrzad Cohenpour, Rachel Lev-Wiesel & Shai Efrati - 2018 - Frontiers in Psychology 9.
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  5.  22
    Hyperbaric Oxygen Therapy Can Induce Angiogenesis and Regeneration of Nerve Fibers in Traumatic Brain Injury Patients.Sigal Tal, Amir Hadanny, Efrat Sasson, Gil Suzin & Shai Efrati - 2017 - Frontiers in Human Neuroscience 11.
  6. Acute cerebral edema: evidence for the efficacy of hyperbaric oxygen and comparison to other modalities.E. P. Kindwall - forthcoming - A Critical Review. In: Camporesi Em and Barker Ac, Editors. Hyperbaric Oxygen: A Critical Review. Bethesda, Md: Undersea and Hyperbaric Medical Society.
     
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  7.  20
    Recovery of Repressed Memories in Fibromyalgia Patients Treated With Hyperbaric Oxygen – Case Series Presentation and Suggested Bio-Psycho-Social Mechanism.Shai Efrati, Amir Hadanny, Shir Daphna-Tekoah, Yair Bechor, Kobi Tiberg, Nimrod Pik, Gil Suzin & Rachel Lev-Wiesel - 2018 - Frontiers in Psychology 9.
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  8.  54
    Significant social events and increasing use of life-sustaining treatment: trend analysis using extracorporeal membrane oxygenation as an example.Yen-Yuan Chen, Likwang Chen, Tien-Shang Huang, Wen-Je Ko, Tzong-Shinn Chu, Yen-Hsuan Ni & Shan-Chwen Chang - 2014 - BMC Medical Ethics 15 (1):21.
    Most studies have examined the outcomes of patients supported by extracorporeal membrane oxygenation as a life-sustaining treatment. It is unclear whether significant social events are associated with the use of life-sustaining treatment. This study aimed to compare the trend of extracorporeal membrane oxygenation use in Taiwan with that in the world, and to examine the influence of significant social events on the trend of extracorporeal membrane oxygenation use in Taiwan.
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  9.  54
    The over-optimistic portrayal of life-supporting treatments in newspapers and on the Internet: a cross-sectional study using extra-corporeal membrane oxygenation as an example.Yen-Yuan Chen, Likwang Chen, Yu-Hui Kao, Tzong-Shinn Chu, Tien-Shang Huang & Wen-Je Ko - 2014 - BMC Medical Ethics 15 (1):59.
    Extra-corporeal membrane oxygenation has been introduced to clinical practice for several decades. It is unclear how internet and newspapers portray the use of extra-corporeal membrane oxygenation. This study were: (1) to quantify the coverage of extra-corporeal membrane oxygenation use in newspapers and on the Internet; (2) to describe the characteristics of extra-corporeal membrane oxygenation users presented in newspaper articles and the Internet web pages in comparison with those shown in extra-corporeal membrane oxygenation studies in Taiwan; and (3) to examine the (...)
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  10.  77
    Neonatal extracorporeal membrane oxygenation (ECMO): clinical trials and the ethics of evidence.V. Mike, A. N. Krauss & G. S. Ross - 1993 - Journal of Medical Ethics 19 (4):212-218.
    Neonatal extracorporeal membrane oxygenation (ECMO), a technology for the treatment of respiratory failure in newborns, is used as a case study to examine statistical and ethical aspects of clinical trials and to illustrate a proposed 'ethics of evidence', an approach to medical uncertainty within the context of contemporary biomedical ethics. Discussion includes the twofold aim of the ethics of evidence: to clarify the role of uncertainty and scientific evidence in medical decision-making, and to call attention to the need to (...)
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  11.  18
    Life-sustaining treatments in end-stage chronic respiratory failure: A single-centre study.Jose Filipe da Purificacao Monteiro - 2018 - Clinical Ethics 13 (1):26-33.
    PurposeThe acute-on-chronic exacerbations of end-stage respiratory diseases often result in prolonged hospital stays, relating these events to ethical conflicts in the fields of medical futility and distributive justice. This study aimed to understand patients’ preferences for life-sustaining treatments when clinically stable and during regular follow-up visits, and to determine the factors that can influence these preferences.ProcedureThis was a prospective, observational, exploratory study using convenience sampling. Over a three-year period, the study enrolled 106 adult outpatients with end-stage pulmonary disease on long-term (...)
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  12.  14
    SUPPORT and the Ethics of Study Implementation: Lessons for Comparative Effectiveness Research from the Trial of Oxygen Therapy for Premature Babies.John D. Lantos & Chris Feudtner - 2015 - Hastings Center Report 45 (1):30-40.
    The Surfactant, Positive Pressure, and Oxygenation Randomized Trial (SUPPORT) has been the focal point of many different criticisms regarding the ethics of the study ever since publication of the trial's findings in 2010 and 2012. In this article, we focus on a concern that the technical design and implementation details of the study were ethically flawed. While the federal Office Human Research Protections focused on the consent form, rather than on the study design and implementation, OHRP's critiques of the consent (...)
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  13.  37
    Improved Optimization for Wastewater Treatment and Reuse System Using Computational Intelligence.Zong Woo Geem, Sung Yong Chung & Jin-Hong Kim - 2018 - Complexity 2018:1-8.
    River water pollution by wastewater can cause significant negative impact on the aquatic sustainability. Hence, accurate modeling of this complicated system and its cost-effective treatment and reuse decision is very important because this optimization process is related to economic expenditure, societal health, and environmental deterioration. In order to optimize this complex system, we may consider three treatment or reuse options such as microscreening filtration, nitrification, and fertilization-oriented irrigation on top of two existing options such as settling and biological (...)
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  14.  13
    A New Precise High Flow Oxygen Therapy System Based on Sliding Mode Control Strategy.Yan Shi, Luyu Xu, Fei Xie, Maolin Cai & Yixuan Wang - 2022 - Complexity 2022:1-12.
    In recent years, precise high flow oxygen therapy as a new type of oxygen therapy machine has gradually attracted people’s attention and has been widely used in hospital emergency and clinical treatment of respiratory diseases; especially in recent years, severe coronavirus disease has played an important role in the treatment of patients. This paper presents a new type of precise high flow oxygen therapy machine with electromagnetic pneumatic flow valve as the core control element. A (...)
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  15.  56
    Factors affecting physicians' decisions to forgo life-sustaining treatments in terminal care.H. Hinkka - 2002 - Journal of Medical Ethics 28 (2):109-114.
    Objectives: Treatment decisions in ethically complex situations are known to depend on a physician's personal characteristics and medical experience. We sought to study variability in decisions to withdraw or withhold specific life-supporting treatments in terminal care and to evaluate the association between decisions and such background factors.Design: Readiness to withdraw or withhold treatment options was studied using a terminal cancer patient scenario with alternatives. Physicians were asked about their attitudes, life values, experience, and training; sociodemographic data were also (...)
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  16.  52
    Gender and age disparity in the initiation of life-supporting treatments: a population-based cohort study.Peng-Sheng Ting, Likwang Chen, Wei-Chih Yang, Tien-Shang Huang, Chau-Chung Wu & Yen-Yuan Chen - 2017 - BMC Medical Ethics 18 (1):62.
    The relationships between age and the life-supporting treatments use, and between gender and the life-supporting treatments use are still controversial. Using extracorporeal membrane oxygenation as an example of life-supporting treatments, the objectives of this study were: to examine the relationship between age and the extracorporeal membrane oxygenation use; to examine the relationship between age and the extracorporeal membrane oxygenation use; and to deliberate the ethical and societal implications of age and gender disparities in the initiation of extracorporeal membrane oxygenation. This (...)
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  17. Should Pediatric Patients Be Prioritized When Rationing Life-Saving Treatments During the COVID-19 Pandemic.Ryan M. Antiel, Farr A. Curlin, Govind Persad, Douglas B. White, Cathy Zhang, Aaron Glickman, Ezekiel J. Emanuel & John Lantos - 2020 - Pediatrics 146 (3):e2020012542.
    Coronavirus disease 2019 can lead to respiratory failure. Some patients require extracorporeal membrane oxygenation support. During the current pandemic, health care resources in some cities have been overwhelmed, and doctors have faced complex decisions about resource allocation. We present a case in which a pediatric hospital caring for both children and adults seeks to establish guidelines for the use of extracorporeal membrane oxygenation if there are not enough resources to treat every patient. Experts in critical care, end-of-life care, bioethics, and (...)
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  18.  7
    Stories of Families with Chronically Ill Pediatric Patients during the War in Ukraine.Vita Voloshchuk - 2023 - Narrative Inquiry in Bioethics 13 (3):5-7.
    In lieu of an abstract, here is a brief excerpt of the content:Stories of Families with Chronically Ill Pediatric Patients during the War in UkraineVita VoloshchukFebruary 24th was a day that has left a mark in the memory and on the lives of every Ukrainian person. My husband and I work together [End Page E5] in a hospital. He had gone into work early to conduct a kidney transplant that had been scheduled for that day. Suddenly, whilst on my way (...)
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  19.  33
    Do-not-attempt-resuscitation (DNAR) orders: understanding and interpretation of their use in the hospitalised patient in Ireland. A brief report.Helen O’Brien, Siobhan Scarlett, Anne Brady, Kieran Harkin, Rose Anne Kenny & Jeanne Moriarty - 2018 - Journal of Medical Ethics 44 (3):201-203.
    Following the introduction of do-not-resuscitate orders in the 1970s, there was widespread misinterpretation of the term among healthcare professionals. In this brief report, we present findings from a survey of healthcare professionals. Our aim was to examine current understanding of the term do-not-attempt-resuscitate, decision-making surrounding DNAR and awareness of current guidelines. The survey was distributed to doctors and nurses in a university teaching hospital and affiliated primary care physicians in Dublin via email and by hard copy at educational meetings from (...)
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  20.  19
    Mitigating ethical conflict and moral distress in the care of patients on ECMO: impact of an automatic ethics consultation protocol.M. Jeanne Wirpsa, Louanne M. Carabini, Kathy Johnson Neely, Camille Kroll & Lucia D. Wocial - 2021 - Journal of Medical Ethics 47 (12):e63-e63.
    AimsThis study evaluates a protocol for early, routine ethics consultation for patients on extracorporeal membrane oxygenation to support decision-making in the context of clinical uncertainty with the aim of mitigating ethical conflict and moral distress.MethodsWe conducted a single-site qualitative analysis of EC documentation for all patients receiving ECMO support from 15 August 2018 to 15 May 2019. Detailed analysis of 20 ethically complex cases with protracted ethics involvement identifies four key ethical domains: limits of prognostication, bridge to nowhere, burden of (...)
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  21.  38
    When Ethics Precludes Randomization: Put Prospective, Matched-Pair Observational Studies to Work.Charles Joseph Kowalski - 2013 - Perspectives in Biology and Medicine 56 (2):184-197.
    In a recent paper in this journal, John Worrall (2008) used the example of a series of trials involving extracorporeal membrane oxygenation (ECMO), a technology for the treatment of respiratory failure in newborns, to illustrate the relationship between ethics and epistemology in medical research. One of the issues considered was whether or not it was ethical to perform a particular clinical trial at all, and he showed clearly that the answer was intimately related to epistemological judgments about the weight (...)
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  22.  13
    Realizing Informed Consent in Times of Controversy: Lessons from the SUPPORT Study.Robert J. Morse & Robin Fretwell Wilson - 2016 - Journal of Law, Medicine and Ethics 44 (3):402-418.
    This Essay examines the elegantly simple idea that consent to medical treatment or participation in human research must be “informed” to be valid. It does so by using as a case study the controversial clinical research trial known as the Surfactant, Positive Pressure, and Oxygenation Randomized Trial. The Essay begins by charting, through case law and the adoption of the common rule, the evolution of duties to secure fully informed consent in both research and treatment. The Essay then (...)
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  23.  59
    Four Models of Family Interests.Daniel Groll - 2014 - Pedatrics 134:S81-S86.
    In this article, I distinguish between 4 models for thinking about how to balance the interests of parents, families, and a sick child: (1) the oxygen mask model; (2) the wide interests model; (3) the family interests model; and (4) the direct model. The oxygen mask model – which takes its name from flight attendants' directives to parents to put on their own oxygen mask before putting on their child's – says that parents should consider their own (...)
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  24.  24
    Were There “Additional Foreseeable Risks” in the SUPPORT Study? Lessons Not Learned from the ARDSnet Clinical Trials.Henry J. Silverman & Didier Dreyfuss - 2015 - Hastings Center Report 45 (1):21-29.
    SUPPORT, a study involving approximately 1,300 premature infants who were randomly assigned to treatment protocols that differed in whether they offered higher or lower levels of oxygen saturation, was purportedly an example of comparative effectiveness research performed in the intensive care unit. However, SUPPORT became highly controversial. One source of controversy involved the proper determination of “reasonably foreseeable risks.” Commentators debated whether randomization to contrasting restrictive strategies that are within existing standard‐of‐care treatments imposed additional “reasonably foreseeable risks” greater (...)
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  25.  97
    The epistemology and ethics of chronic disease research: Further lessons from ecmo.Robyn Bluhm - 2010 - Theoretical Medicine and Bioethics 31 (2):107-122.
    Robert Truog describes the controversial randomized controlled trials (RCTs) of extracorporeal membrane oxygenation (ECMO) therapy in newborns. Because early results with ECMO indicated that it might be a great advance, saving many lives, Truog argues that ECMO should not have been tested using RCTs, but that a long-term, large-scale observational study of actual clinical practice should have been conducted instead. Central to Truog’s argument, however, is the idea that ECMO is an unusual case. Thus, it is an open question whether (...)
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  26.  35
    An open letter to institutional review boards considering northfield laboratories' polyheme® trial.Ken Kipnis, Nancy M. P. King & Robert M. Nelson - 2006 - American Journal of Bioethics 6 (3):18 – 21.
    At the time of this writing, a widely publicized, waived-consent trial is underway. Sponsored by Northfield Laboratories, Inc. (Evanston, IL) the trial is intended to evaluate the emergency use of PolyHeme®, an oxygen-carrying resuscitative fluid that might prevent deaths from uncontrolled bleeding. The protocol allows patients in hemorrhagic shock to be randomized between PolyHeme® and saline in the field and, still without consent, randomized between PolyHeme® and blood after arrival at an emergency department. The Federal regulations that govern the (...)
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  27.  14
    Ethics briefing.Ruth Campbell, Sophie Brannan, Veronica English, Olivia Lines, Rebecca Mussell & Julian C. Sheather - 2020 - Journal of Medical Ethics 46 (6):397-398.
    Healthcare professionals are currently working under extreme pressure as they respond to the pandemic outbreak of COVID-19. At the time of writing, there is currently no effective vaccine or anti-viral treatment. The pandemic is fast-moving, relatively unpredictable and of uncertain duration. In many countries, it is placing an enormous stress on healthcare resources and providing care to existing standards is proving difficult. Unfortunately, in some countries, health services have been overwhelmed. The impact of the pandemic on resource-poor countries is (...)
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  28.  36
    An Open Letter to Institutional Review Boards Considering Northfield Laboratories’ PolyHeme® Trial.Robert M. Nelson, Nancy M. P. King & Ken Kipnis - 2010 - American Journal of Bioethics 10 (10):5-8.
    At the time of this writing, a widely publicized, waived-consent trial is underway. Sponsored by Northfield Laboratories, Inc. (Evanston, IL) the trial is intended to evaluate the emergency use of PolyHeme®, an oxygen-carrying resuscitative fluid that might prevent deaths from uncontrolled bleeding. The protocol allows patients in hemorrhagic shock to be randomized between PolyHeme® and saline in the field and, still without consent, randomized between PolyHeme® and blood after arrival at an emergency department. The Federal regulations that govern the (...)
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  29.  28
    Within- and Between-Session Prefrontal Cortex Response to Virtual Reality Exposure Therapy for Acrophobia.Aleksandra Landowska, David Roberts, Peter Eachus & Alan Barrett - 2018 - Frontiers in Human Neuroscience 12:351048.
    Exposure Therapy (ET) has demonstrated its efficacy in the treatment of phobias, anxiety and Post-traumatic Stress Disorder (PTSD), however, it suffers a high drop-out rate because of too low or too high patient engagement in treatment. Virtual Reality Exposure Therapy (VRET) is comparably effective regarding symptom reduction and offers an alternative tool to facilitate engagement for avoidant participants. Neuroimaging studies have demonstrated that both ET and VRET normalize brain activity within a fear circuit. However, previous studies have employed (...)
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  30.  6
    Case study. Whose bed? Commentary.Hannah I. Lipman - 2013 - Hastings Center Report 43 (2):14.
    Richard, a sixty‐seven‐year‐old man, has been admitted to Midtown University Center for difficulty breathing. He has a significant medical history that includes pulmonary fibrosis and subsequent heart failure, and he depends on supplemental oxygen to breathe. Upon admission and after discussing his prognosis with his family and doctors, Richard decided to sign a do‐not‐resuscitate order stating that if his heart stops or he stops breathing, he does not want to undergo cardiopulmonary resuscitation or other life‐sustaining measures. On his third (...)
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  31.  11
    SUPPORT: Risks, Harms, and Equipoise.Robert M. Nelson - 2015 - Hastings Center Report 45 (1):40-42.
    The debate about the ethics of the Surfactant, Positive Pressure, and Oxygenation Randomized Trial (SUPPORT) often focuses on the assumptions made by the different parties involved, failing to note the lack of a necessary connection between those assumptions and the main criticism of the study—that the parents appear to have been poorly informed. The fact that the target ranges of oxygen saturation (SpO2) used in SUPPORT were within the range recommended as an appropriate “standard of care” does not mean (...)
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  32.  68
    A View from the Netherlands: Ethics as Interactive Evaluation.Rob Reuzel, Gert Jan Van der Wilt, Pieter de Vries Robbé & Henk ten Have - 2001 - Cambridge Quarterly of Healthcare Ethics 10 (1):110-114.
    From 1991 to 1994 the Dutch Health Insurance Council financed research on Extracorporeal Membrane Oxygenation (ECMO). This is a technique for providing cardiopulmonary bypass to patients with pulmonary and/or cardiac failure. Most often, these patients are premature neonates. During ECMO, blood is drained from the right atrium, pumped along a membrane where gas exchange takes place, and then redirected to the aorta. To prevent blood clotting, heparin is added. However, with the heparin added, the risk of hemorrhage is considerably increased. (...)
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  33.  19
    A View from the Netherlands: Ethics as Interactive Evaluation.Rob Reuzel, Gert Jan van Der Wilt, Pieter Vries Robbdeé & Henk ten Have - 2001 - Cambridge Quarterly of Healthcare Ethics 10 (1):110-114.
    From 1991 to 1994 the Dutch Health Insurance Council financed research on Extracorporeal Membrane Oxygenation . This is a technique for providing cardiopulmonary bypass to patients with pulmonary and/or cardiac failure. Most often, these patients are premature neonates. During ECMO, blood is drained from the right atrium, pumped along a membrane where gas exchange takes place, and then redirected to the aorta. To prevent blood clotting, heparin is added. However, with the heparin added, the risk of hemorrhage is considerably increased. (...)
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  34.  11
    Chronic Pain and Aberrant Drug-Related Behavior in the Emergency Department.Knox H. Todd - 2005 - Journal of Law, Medicine and Ethics 33 (4):761-769.
    Pain is the single most common reason patients seek care in the emergency department. Given the prevalence of pain as a presenting complaint, one might expect emergency physicians to assign its treatment a high priority; however, pain is often seemingly invisible to the emergency physician. Multiple research studies have documented that the undertreatment of pain, or oligoanalgesia, is a frequent occurrence. Pain that is not acknowledged and managed appropriately causes dissatisfaction with medical care, hostility toward the physician, unscheduled returns (...)
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  35.  6
    Whose Bed?Bonnie Tong & Hannah I. Lipman - 2013 - Hastings Center Report 43 (2):13-14.
    Richard, a sixty‐seven‐year‐old man, has been admitted to Midtown University Center for difficulty breathing. He has a significant medical history that includes pulmonary fibrosis and subsequent heart failure, and he depends on supplemental oxygen to breathe. Upon admission and after discussing his prognosis with his family and doctors, Richard decided to sign a do‐not‐resuscitate order stating that if his heart stops or he stops breathing, he does not want to undergo cardiopulmonary resuscitation or other life‐sustaining measures. On his third (...)
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  36. Involuntary Withdrawal: A Bridge Too Far?Joanna Smolenski - 2023 - Clinical Ethics Case Studies, Hastings Bioethics Forum.
    RD, a 32-year-old male, was admitted to the hospital with hypoxic COVID pneumonia–a potentially life-threatening condition characterized by dangerously low levels of oxygen in the body- during one of the pandemic’s surges. While RD’s age gave the clinical team hope for his prognosis, his ability to recover was complicated by his being unvaccinated and having multiple comorbidities, including diabetes and obesity. His condition worsened to the point that he required extracorporeal membrane oxygenation (ECMO), a machine that maintains the functioning (...)
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  37.  19
    Drawing the Boundaries of Nanoscience — Rationalizing the Concerns?Mario Kaiser - 2006 - Journal of Law, Medicine and Ethics 34 (4):667-674.
    Imagine your body is populated by billions of respirocytes capable of delivering 236 times more oxygen than your natural red blood cells. These mechanical, micron sized spheres are appropriately programmed by your physician to meet your personal requirements, be it the treatment of anemia or the enhancement of your physical abilities. Robert Freitas’ vision of such artificial blood cells comprised of nanometer-scale components was published in 1998 in a peer-reviewed medical journal, and was the first medical nanorobot design (...)
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  38.  7
    新冠肺炎重症患者ECMO治療的倫理考量.H. A. N. Dan - 2022 - International Journal of Chinese and Comparative Philosophy of Medicine 20 (1):27-40.
    LANGUAGE NOTE | Document text in Chinese; abstract also in English. ECMO是一項高風險、高創傷、高消耗的創新技術,它能夠為新冠病毒肺炎重症患者提供挽救性治療°ECMO的治療目標是幫助患者恢復心肺功能,或者橋接最終治療,包括器械植入,或者器官移植等。然而,容易被忽視的 事實是,ECMO挽救了一些患者的生命,但也可能讓那些沒有康復機會的患者陷入醫療困境。於是,ECMO的臨床應用不得不面對一些反對意見,包括嚴重併發症危害患者生命安全、無效治療導致技術失敗,以及大量佔用資 源損害醫療公平等。ECMO技術的臨床應用應該在尊重生命價值和患者意願的基礎上,合理設置治療目標、確立可接受退出標準、妥善處理患者意願與ECMO設備撤除困境之間的倫理衝突,建立適度倫理框架以合理控制醫療 干預的邊界。 Characterized by high risk, high trauma and high consumption, Extra-Corporeal Membrane Oxygenation (ECMO) is an innovative technology that can be used as salvage therapy for COVID-19 patients. ECMO treatment can help restore patients' cardiopulmonary function or can bridge their final treatment, including device implantation or organ transplantation. However, although ECMO saves some patients' lives, it can also leave those with no chance of recovery in a medical (...)
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  39.  11
    Living with Blindness and Fibromyalgia while Occupying Aging.Katherine Schneider - 2013 - Narrative Inquiry in Bioethics 3 (3):216-218.
    In lieu of an abstract, here is a brief excerpt of the content:Living with Blindness and Fibromyalgia while Occupying AgingKatherine SchneiderI’m blind from birth and in middle age developed fibromyalgia. I’ve retired from a thirty year career as a clinical psychologist and am working on my third book tentatively titled “Occupying Aging: Delights, Disabilities and Daily Life.” My relationship with medical professionals includes gratitude (without good care I would not be alive) and also frustration for assumptions often made about my (...)
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  40. The place of pleasure in Aristotle's ethics.Amelie Oksenberg Rorty - 1974 - Mind 83 (332):481-497.
    BACKGROUND: Although placing patients with acute respiratory failure in a prone (face down) position improves their oxygenation 60 to 70 percent of the time, the effect on survival is not known. METHODS: In a multicenter, randomized trial, we compared conventional treatment (in the supine position) of patients with acute lung injury or the acute respiratory distress syndrome with a predefined strategy of placing patients in a prone position for six or more hours daily for 10 days. We enrolled 304 (...)
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  41.  5
    Chronic Pain and Aberrant Drug-Related Behavior in the Emergency Department.Knox H. Todd - 2005 - Journal of Law, Medicine and Ethics 33 (4):761-769.
    Pain is the single most common reason patients seek care in the emergency department. Given the prevalence of pain as a presenting complaint, one might expect emergency physicians to assign its treatment a high priority; however, pain is often seemingly invisible to the emergency physician. Multiple research studies have documented that the undertreatment of pain, or oligoanalgesia, is a frequent occurrence. Pain that is not acknowledged and managed appropriately causes dissatisfaction with medical care, hostility toward the physician, unscheduled returns (...)
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  42.  91
    The Art of Dying Well.Lydia Dugdale - 2010 - Hastings Center Report 40 (6):22-24.
    The scenario is all too common: the elderly woman with end-stage dementia readmitted to the hospital for the fourth time in three months for anorexia, now static cancer progressing despite all proven chemotherapy now pursuing a toxic experimental treatment, or the patient with a rampant infection leading to multiple organ failure who requires machines, medications, and devices to filter the blood, pump the heart, exchange oxygen, facilitate clotting, and provide nutrition. Modern medical science is adept at sustaining life. (...)
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  43.  74
    The dilemma of jehovah's witness children who need blood to survive.Anita Catlin - 1996 - HEC Forum 8 (4):195-207.
    Medical researchers must continue to develop and test non-blood oxygen-transport products. Resources provided by the Jehovah's Witness Hospital Assistance Line must be consulted. Sickle cell researchers must continue to test non-blood treatment. Information about non-blood treatments must be disbursed. Ways to enhance parental comport as the laws further and further support children's best interest must be provided. Information regarding cultural diversity must be disseminated. Hospitals and healthcare agencies that have not done so must institute the use of ethics (...)
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  44.  32
    Cellular lifespan and senescence: a complex balance between multiple cellular pathways.David Dolivo, Sarah Hernandez & Tanja Dominko - 2016 - Bioessays 38 (S1):33-44.
    The study of cellular senescence and proliferative lifespan is becoming increasingly important because of the promises of autologous cell therapy, the need for model systems for tissue disease and the implication of senescent cell phenotypes in organismal disease states such as sarcopenia, diabetes and various cancers, among others. Here, we explain the concepts of proliferative cellular lifespan and cellular senescence, and we present factors that have been shown to mediate cellular lifespan positively or negatively. We review much recent literature and (...)
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  45.  12
    The Controversy over SUPPORT Continues and the Hyperbole Increases.Alan R. Fleischman - 2015 - Hastings Center Report 45 (1):42-44.
    Two articles in this issue of the Hastings Center Report address the continuing controversy over the Surfactant, Positive Pressure, and Oxygenation Randomized Trial (SUPPORT). This controversy is part of a larger discussion about the appropriate regulatory framework for protecting human research participants in comparative effectiveness research (CER), a group of studies that aims to compare two “usual” or “standard” treatments in order to provide evidence of which treatment is most effective.
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  46.  96
    Should Zelen pre-randomised consent designs be used in some neonatal trials?P. Allmark - 1999 - Journal of Medical Ethics 25 (4):325-329.
    My aim is to suggest that there is a case for using a randomised consent design in some neonatal trials. As an example I use the trials of extracorporeal membrane oxygenation (ECMO) in neonates suffering pulmonary hypertension. In some trials the process of obtaining consent has the potential to harm the subject, for example, by disappointing those who end in the control group and by creating additional anxiety at times of acute illness. An example of such were the trials of (...)
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  47.  16
    A single-session Mindfulness-Based Swinging Technique vs. cognitive disputation intervention among women with breast cancer: A pilot randomised controlled study examining the efficacy at 8-week follow-up.Ozan Bahcivan, Jose Gutierrez-Maldonado & Tania Estapé - 2022 - Frontiers in Psychology 13.
    ObjectivePreviously Mindfulness-Based Swinging Technique 's immediate efficacy for overcoming psychological concerns has recently received empirical support, yet its longer-term efficacy needed to be evaluated among women with breast cancer. The objective of this study was to assess and report the efficacy of MBST intervention among breast cancer patients for hopelessness, anxiety, depression, self-efficacy, oxygen intensity, and heart rate-beats per minute at an 8-week period.MethodThe State-Trait Anxiety Inventory, The Emotion Thermometer, Hospital Anxiety and Depression Scale, Self-Efficacy for Managing Chronic Disease, (...)
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  48.  9
    Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?Laura Jadkauskaite, Pierre A. Coulombe, Matthias Schäfer, Albena T. Dinkova-Kostova, Ralf Paus & Iain S. Haslam - 2017 - Bioessays 39 (8):1700029.
    Widespread expression of the transcription factor, nuclear factor (erythroid‐derived 2)‐like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy‐induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide‐induced hair growth inhibition. Multiple parameters can increase the levels of reactive (...)
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  49.  8
    Moral Distress for the Physician Assistant.Sharyn L. Kurtz - 2013 - Narrative Inquiry in Bioethics 3 (2):13-16.
    In lieu of an abstract, here is a brief excerpt of the content:Moral Distress for the Physician AssistantSharyn L. KurtzMy morning rounds as an inpatient medical oncology physician assistant began as usual. I arrived at the hospital early to receive 7 a.m. sign out from the covering resident. The overnight report began favorably. All patients remained stable. Even my patient, whom I will call Mrs. Walker,* had a quiet night. However, given her tenuous admission presentation, including altered mental status, hypercalcemia (...)
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  50.  12
    mTORC1 and ferroptosis: Regulatory mechanisms and therapeutic potential.Guang Lei, Li Zhuang & Boyi Gan - 2021 - Bioessays 43 (8):2100093.
    Ferroptosis, a form of regulated cell death triggered by lipid hydroperoxide accumulation, has an important role in a variety of diseases and pathological conditions, such as cancer. Targeting ferroptosis is emerging as a promising means of therapeutic intervention in cancer treatment. Polyunsaturated fatty acids, reactive oxygen species, and labile iron constitute the major underlying triggers for ferroptosis. Other regulators of ferroptosis have also been discovered recently, among them the mechanistic target of rapamycin complex 1 (mTORC1), a central controller (...)
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