In this essay I explore a possibility of experiential synthesis of the medicalized abnormal body with its aesthetic images. A personal narrative about meeting extreme abnormality serves as an introduction into theorizing aesthetic abnormality. The essay builds its argument on the phenomenological grounds; I therefore approach corporeality with Edmund Husserl and Maurice Merleau-Ponty. In turn, Max Ernst introduces an aesthetic frame for the subsequent examination of uncanny surreality. Two exemplars of the surreal body, Joel Witkins "Satiro" and Don DeLillds "Body (...) Artist," intend to substantiate the preceding theoretic. The study shows how the encounter with the abnormal embodiment may suspend normalized modes of constitution to provoke uncanny experiences. (shrink)

This article approaches a potential tension in the work of Slavoj Žižek between his critique of communist ideology and his endorsement of the communist idea. The aim is to show how this endorsement, in effect, emerged out of Žižek’s sustained engagement with communist ideology. The article captures this transformation by focusing on his understanding of the notion of the idea and the ways in which ideology can be transgressed. The conclusion drawn is that in moving from a Kantian to a (...) Hegelian notion of the idea, Žižek also leaves behind his initial Beckettian Leninism in favor of an understanding of revolution that no longer depends on the heroic act of a subject, but on the immanent logic of the communist idea. (shrink)

Dieser Artikel untersucht den zweideutigen Status der Rhetorik, der zwischen echter Philosophie und bloßer Sophisterei angesiedelt ist, anhand von Alan Badious drei exemplarischen Denkfiguren: dem Philosophen, dem Anti-Philosophen und dem Sophisten. Mit der jüngsten Rückkehr des Sophisten in die Politik in Form populistischer Politiker hat die zeitgenössische Rhetorikforschung die Notwendigkeit zum Ausdruck gebracht, dass die Disziplin ihr Bündnis mit der relativistischen Sophistik überdenkt. Indem Badious drei exemplarische Figuren untersucht und sie mit seinem Verständnis der drei Formen der Negation in Beziehung (...) gesetzt werden, untersucht der Artikel eine mögliche Kluft zwischen sophistischer Rhetorik und antiphilosophischem Populismus, die das vorherrschende Verständnis der Beziehung zwischen Rhetorik, Philosophie und Sophistik verkompliziert. Schließlich wirft der Artikel einige Fragen dazu auf, wie die Exemplarität im Allgemeinen und die drei exemplarischen Figuren im Besonderen in den Rahmen von Badious gesamter Philosophie eingeordnet werden können, und erörtert, wie man diesen Einschränkungen möglicherweise entgegenwirken kann. (shrink)

Western societies today are coming unmoored in the face of an earth-shaking ethical and cultural paradigm shift. At its core is the question of what it means to be human and how we are meant to live. The old answers are no longer accepted; a dizzying array of options are offered in their stead. Underpinning this smorgasbord of lifestyles is a thicket of unquestioned assumptions, such as the separation of gender from biological sex, which not so long ago would have (...) been universally rejected as radical notions. In the spring of 2019, a group of Orthodox Christian scholars drawn from a wide variety of academic disciplines met together to offer responses to the moral crisis our generation faces, elaborating upon its various forms and facilitating a fuller understanding of some of its theological and philosophical foundations. In doing so they offer support to all those who question the claims that are so forcefully insisted upon today--a clarity that will aid them in standing up and resisting trends that have already shown to be the cause of great suffering and unhappiness. (shrink)

Can there be grounding without necessitation? Can a fact obtain wholly in virtue of metaphysically more fundamental facts, even though there are possible worlds at which the latter facts obtain but not the former? It is an orthodoxy in recent literature about the nature of grounding, and in first-order philosophical disputes about what grounds what, that the answer is no. I will argue that the correct answer is yes. I present two novel arguments against grounding necessitarianism, and show that grounding (...) contingentism is fully compatible with the various explanatory roles that grounding is widely thought to play. (shrink)

The scaling of body parts is central to the evolution of morphology and shape. Most traits scale proportionally with each other and body size such that larger adults are essentially magnified versions of smaller ones. This pattern is so ubiquitous that departures from it – disproportionate scaling between trait and body size – pique interest because it can generate dramatically exaggerated traits. These extreme morphologies are frequently hypothesized to result from sexual selection and their study has a long history, with (...) several hypotheses seeking to explain their evolution. Despite this effort, surprisingly little progress has been made in demonstrating the forms of selection that produce different scaling patterns or in identifying the mechanisms that underlie the expression and evolution of scaling relationships. Here we review recent insights regarding the proximate mechanisms that regulate and integrate trait growth and that offer a new framework for studying the evolution of morphological scaling. (shrink)

Among all organisms, the size of each body part or organ scales with overall body size, a phenomenon called allometry. The study of shape and form has attracted enormous interest from biologists, but the genetic, developmental and physiological mechanisms that control allometry and the proportional growth of parts have remained elusive. Recent progress in our understanding of body‐size regulation provides a new synthetic framework for thinking about the mechanisms and the evolution of allometric scaling. In particular, insulin/IGF signaling, which plays (...) major roles in longevity, diabetes and the regulation of cell, organ and body size, might also be centrally involved in regulating organismal shape. Here we review recent advances in the fields of growth regulation and endocrinology and use them to construct a developmental model of static allometry expression in insects. This model serves as the foundation for a research program that will result in a deeper understanding of the relationship between growth and form, a question that has fascinated biologists for centuries. BioEssays 29:536–548, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Common errors on the mind.--Errors of suppressed correlatives.--The civil service examinations.--The classical controversy.--Metaphysics and debating societies.--The university ideal, past and present.--The art of study.--Religious tests and subscriptions.--Procedure of deliberative bodies.

This book explores the nature of meaning, primarily through readings of the work of Walter Benjamin and Ludwig Wittgenstein. Alexander Stern offers a critical analysis of Benjamin's philosophy of language, finding in it a common root with Wittgenstein's thought on language, and traces the historical foundation of both accounts of meaning to eighteenth- and nineteenth-century German philosophy. Benjamin's theory of language is notoriously dense and obscure. In elucidating it, Stern emphasizes Benjamin's attempt to reorient the Kantian project around language-the (...) medium in which knowledge is expressed-and his concern with the logical understanding of language gaining credence in the work of Bertrand Russell and Gottlob Frege. The result is a radical model of the relationship between language, experience, and the world that sees "absolutely everything" as linguistic in a broadened sense and which sees the logical or designative capacities of language as grounded in an aesthetic foundation. Wittgenstein and Benjamin are read in the book as complementary to one another, sharing comparable critiques of empiricism and comparable accounts of concept use, linguistic understanding, and the relation between experience and language. Although this similarity breaks down over Wittgenstein's account of the "experience of meaning," which is subordinated to his account of meaning as use, Stern argues that Benjamin's theory of language can productively address some unresolved issues in Wittgenstein's understanding of meaning. (shrink)

In this article I raise a new problem for quantum mechanics, which I call the control problem. Like the measurement problem, the control problem places a fundamental constraint on quantum theories. The characteristic feature of the problem is its focus on state preparation. In particular, whereas the measurement problem turns on a premise about the completeness of the quantum state (‘no hidden variables’), the control problem turns on a premise about our ability to prepare or control quantum states. After raising (...) the problem, I discuss some applications. I suggest that it provides a useful new lens through which to view existing theories or interpretations, in part because it draws attention to aspects of those theories that the measurement problem does not (such as the role of conditional and relative states). I suggest that it also helps clarify the physical significance of the well-known no-go result—the no-cloning theorem—on which it is based. (shrink)

According to some philosophers who accept a propositional conception of evidence, someone's evidence includes a proposition only if it is true. I argue against this thesis by appealing to the possibility of knowledge from falsehood.

Solving the “new demarcation problem” requires a distinction between epistemically legitimate and illegitimate roles for non-epistemic values in science. This paper addresses one ‘half’ (i.e. a sub-problem) of the new demarcation problem articulated by the Gretchenfrage: What makes the role of a non-epistemic value in science epistemically illegitimate? I will argue for the Explaining Epistemic Errors (EEE) account, according to which the epistemically illegitimate role of a non-epistemic value is defined via an explanatory claim: the fact that an epistemic agent (...) is motivated by a non-epistemic value explains why the epistemic agent commits a particular epistemic error. The EEE account is inspired by Douglas’ and Steel’s “functionalist” or “epistemic constraint” accounts of epistemic illegitimacy. I will suggest that the EEE account is able to meet two challenges that these two accounts face, while preserving the key intuition underlying both accounts. If my arguments succeed, then the EEE account provides a solution to one half of the new demarcation problem (by providing a definition of what makes the role of a non-epistemic value epistemically illegitimate) and it opens up new ways for addressing the other half (i.e. characterizing an epistemically legitimate role for non-epistemic values). (shrink)

The medial prefrontal cortex (mPFC) has been the subject of intense interest as a locus of cognitive control. Several computational models have been proposed to account for a range of effects, including error detection, conflict monitoring, error likelihood prediction, and numerous other effects observed with single-unit neurophysiology, fMRI, and lesion studies. Here, we review the state of computational models of cognitive control and offer a new theoretical synthesis of the mPFC as signaling response–outcome predictions. This new synthesis has two interacting (...) components. The first component learns to predict the various possible outcomes of a planned action, and the second component detects discrepancies between the actual and intended responses; the detected discrepancies in turn update the outcome predictions. This single construct is consistent with a wide array of performance monitoring effects in mPFC and suggests a unifying account of the cognitive role of medial PFC in performance monitoring. (shrink)

Nicholas Dixon’s Kantian argument for why mixed martial arts (MMA) is intrinsically immoral has received several critical responses. We offer an additional critical response. Unlike previous responses, ours does not rely on an interpretation of the categorical imperative that Dixon would find tendentious. Instead, we grant that Dixon’s views about what makes other sports consistent with the categorical imperative are correct and argue from this assumption that MMA is also consistent with the categorical imperative. Our argument focuses on Dixon’s claims (...) about certain cycling tactics, which we call ‘pain-leveraging cycling tactics’. We argue that MMA is consistent with the categorical imperative for the same sort of reasons that Dixon claims make pain-leveraging cycling tactics consistent with the categorical imperative. (shrink)

In a homogeneous jury, the votes are exchangeable correlated Bernoulli random variables. We derive the bounds on a homogeneous jury’s competence as the minimum and maximum probability of the jury being correct, which arise due to unknown correlations among the votes. The lower bound delineates the downside risk associated with entrusting decisions to the jury. In large and not-too-competent juries the lower bound may fall below the success probability of a fair coin flip—one half, while the upper bound may not (...) reach a certainty. We also derive the bounds on the voting power of an individual juror as the minimum and maximum probability of her/his casting a decisive vote. The maximum is less than one, while the minimum of zero can be attained for infinitely many combinations of distribution moments. (shrink)

This chapter contains sections titled: Introduction The PSR Nonlocal CPs Toward a First Cause The Gap Problem Conclusions and Further Research References.

Classical real-valued probabilities come at a philosophical cost: in many infinite situations, they assign the same probability value—namely, zero—to cases that are impossible as well as to cases that are possible. There are three non-classical approaches to probability that can avoid this drawback: full conditional probabilities, qualitative probabilities and hyperreal probabilities. These approaches have been criticized for failing to preserve intuitive symmetries that can be preserved by the classical probability framework, but there has not been a systematic study of the (...) conditions under which these symmetries can and cannot be preserved. This paper fills that gap by giving complete characterizations under which symmetries understood in a certain “strong” way can be preserved by these non-classical probabilities, as well as by offering some results to make it plausible that the strong notion of symmetry here is the right one. Philosophical implications are briefly discussed, but the main purpose of the paper is to offer technical results to help make further philosophical discussion more sophisticated. (shrink)

Mainstream economics has been accused of excessive mathematization, whereas the rejection of mathematical and other formal methods is often cited as a crucial trait of Austrian economics. Based on a systematic discussion of potential benefits and drawbacks of formalization, this paper corroborates legitimate concerns that predominant types of mathematization induce a shift of attention away from the key concepts of Austrian economics. Taking this shift to the extreme, predominant modes of mathematization tend to accompany a detachment from ‘reality’ incompatible with (...) Austrian pleas for realisticness. Contrary to popular prejudice however, the most prominent representatives of the Austrian School including Carl Menger, Ludwig Mises, Friedrich Hayek, Israel Kirzner, and Peter Boettke neither provide a justification for a wholesale rejection of formalization nor actually reject it. Adequate formalization can serve as a remedy for lacking logical and semantic rigor in standard mathematical economics as well as in murky verbal chains of reasoning. (shrink)

Logical empiricism and the Austrian School of economics are two of the internationally most influential intellectual movements with Viennese roots. By and large independently of each other, both have been subject to detailed historical and philosophical investigations for the last two dec-ades. However, in spite of numerous connections and interactions be-tween the two groups, their relationship has captured surprisingly sparse attention. My dissertation focuses on the many-faceted juxtaposition of two supposedly antagonistic championsof Viennese Late Enlightenment: logical empiricist Otto Neurath and (...) Austrian economist Ludwig Mises. I rationally reconstruct and critically compare their epistemological, meth-odological, and economic positions and demonstrate that a closer look reveals more compatibilities and similarities than acknowledged by the received view and by the protagonists themselves. Over and above the historiographic task of challenging and amending this received view, the analytic components of my thesis inform contemporary debates in phi-losophy, politics, economics, and other sciences. (shrink)

ObjectiveCo-morbid insomnia and sleep apnea is a common and debilitating condition that is more difficult to treat compared to insomnia or sleep apnea-alone. Emerging evidence suggests that cognitive behavioral therapy for insomnia is effective in patients with COMISA, however, those with more severe sleep apnea and evidence of greater objective sleep disturbance may be less responsive to CBTi. Polysomnographic sleep study data has been used to predict treatment response to CBTi in patients with insomnia-alone, but not in patients with COMISA. (...) We used randomized controlled trial data to investigate polysomnographic predictors of insomnia improvement following CBTi, versus control in participants with COMISA.MethodsOne hundred and forty five participants with insomnia and sleep apnea [apnea-hypopnea index ≥ 15] were randomized to CBTi or no-treatment control. Mixed models were used to investigate the effect of pre-treatment AHI, sleep duration, and other traditional, and novel [quantitative electroencephalography ] polysomnographic predictors of between-group changes in Insomnia Severity Index scores from pre-treatment to post-treatment.ResultsCompared to control, CBTi was associated with greater ISI improvement among participants with; higher AHI, less wake after sleep onset, and less N3 sleep. No quantitative electroencephalographic, or other traditional polysomnographic variables predicted between-group ISI change.DiscussionAmong participants with COMISA, higher OSA severity predicted a greater treatment-response to CBTi, versus control. People with COMISA should be treated with CBTi, which is effective even in the presence of severe OSA and objective sleep disturbance. (shrink)

The General Data Protection Regulation (GDPR) of the EU confirms the protection of personal data as a fundamental human right and affords data subjects more control over the way their personal information is processed, shared, and analyzed. However, where data are processed by artificial intelligence (AI) algorithms, asserting control and providing adequate explanations is a challenge. Due to massive increases in computing power and big data processing, modern AI algorithms are too complex and opaque to be understood by most data (...) subjects. Articles 15 and 22 of the GDPR provide a modest regulatory framework for automated data processing by, among other things, mandating that data controllers inform data subjects about when it is being used, and its logic and ramifications. Nevertheless, due to the phrasing of the articles and the numerous exceptions they allow, doubts have arisen about their effectiveness. In this paper, we empirically evaluate the quality and effectiveness of AI disclosures as mandated by the GDPR. By means of an online survey (N = 835), we investigated how data subjects expect to be informed about the automated processing of their data. We then conducted a content analysis of the AI disclosures of N = 100 companies and organizations. The combined findings reveal that current GDPR-mandated disclosures do not meet the expectations and needs of data subjects. Explanations drawn up following the guidelines of the generic formulations of the GDPR differ widely and are often vague, incomplete and lack transparency. In our conclusions we identify a path towards standardizing and optimizing AI information notices. (shrink)

Scoring rules measure the deviation between a credence assignment and reality. Probabilism holds that only those credence assignments that satisfy the axioms of probability are rationally admissible. Accuracy-based arguments for probabilism observe that given certain conditions on a scoring rule, the score of any non-probability is dominated by the score of a probability. The conditions in the arguments we will consider include propriety: the claim that the expected accuracy of _p_ is not beaten by the expected accuracy of any other (...) credence _c_ by the lights of _p_ if _p_ is a probability. I argue that if we think through how a non-probabilist can respond to pragmatic arguments for probabilism, we will expect the non-probabilist to accept a condition _stronger_ than propriety for the same reasons that the probabilist gives for propriety, but this stronger condition is incompatible with the other conditions that the probabilist needs to run the accuracy argument. This makes it unlikely for the probabilist’s argument to be compelling. (shrink)

Any serious student attempting to better understand the nature, methods, and justification of science will value Alex Rosenberg's and Lee McIntyre's updated and substantially revised Fourth Edition of Philosophy of Science: A Contemporary Introduction. Weaving lucid explanations with clear analyses, the volume is as a much-used, thematically-oriented introduction to the field.

Society has reached a new rupture in the digital age. Traditional technologies of biopower designed around coercion no longer dominate. Psychopower has manifested, and its implementation has changed the way one understands biopolitics. This discussion note references Byung-Chul Han’s interpretation of modern psychopolitics to investigate whether basic human rights violations are committed by Facebook, Inc.’s product against its users at a psychopolitical level. This analysis finds that Facebook use can lead to international human rights violations, specifically cultural rights, social rights, (...) rights to self-determination, political rights, and the right to health. (shrink)

It is often loosely said that Ramsey The foundations of mathematics and other logical essays, Routledge and Kegan Paul, Abingdon, pp 156–198, 1931) and de Finetti Studies in subjective probability, Kreiger Publishing, Huntington, 1937) proved that if your credences are inconsistent, then you will be willing to accept a Dutch Book, a wager portfolio that is sure to result in a loss. Of course, their theorems are true, but the claim about acceptance of Dutch Books assumes a particular method of (...) calculating expected utilities given the inconsistent credences. I will argue that there are better ways of calculating expected utilities given a potentially inconsistent credence assignment, and that for a large class of credences—a class that includes many inconsistent examples—these ways are immune to Dutch Books and single-shot domination failures. The crucial move is to replace Finite Additivity with Monotonicity, then \\le P\)) and then calculate expected utilities for positive U via the formula \\, dy\). This shows that Dutch Book arguments for probabilism, the thesis that one’s credences should be consistent, do not establish their conclusion. Finally, I will consider a modified argument based on multi-step domination failure that does better, but nonetheless is not as compelling as the Dutch Book arguments appeared to be. (shrink)

In recent years, counterfeiting has grown exponentially and has now become a grave economic problem. The acquisition of counterfeits poses an ethical dilemma as it benefits the buyer and illegal seller at the cost of the legitimate producer and with fewer taxes being paid throughout the supply chain. Previous research reveals inconsistent and sometimes inconclusive findings regarding whether materialism is associated, positively or negatively, with intentions to purchase counterfeits. The current research seeks to resolve these inconsistencies by investigating previously ignored (...) interactions between three variables: risk of embarrassment, counterfeit detectability and product conspicuousness. First, risk of embarrassment mediates the relationship between materialism and counterfeit purchase intentions. Specifically, materialism negatively predicts counterfeit purchase intentions as mediated by risk of embarrassment. Second, this relationship only holds when the counterfeit can be easily detected. When it is not easily detected, materialism instead leads to positive purchase intentions. Third, these positive effects can be offset when the product is not highly visible. This research has important implications for marketers, manufacturers and academics and contributes to better understanding the antecedents of counterfeit purchases. (shrink)

Ayelet Shachar's The Shifting Border deploys a powerful map metaphor to support rethinking of borders and their functions. I interrogate this metaphor, developing some of the representational, constructive, and normative functions of maps, along with their connections to legal mechanisms for decoupling migration from territory. I survey three responses to the extra-territorialization of migration: a cynical response that rejects the possibility of migration justice, an abolitionist response connected to open borders, and a revisionist response that advocates for widescale institutional reform. (...) The revisionist response illuminates how Shachar's essay challenges us to reflect on what sorts of maps and accompanying social and political organizations would best support migrant justice. (shrink)

Journal of Political Philosophy, Volume 30, Issue 1, Page 48-69, March 2022.

The advent of societies with low employment rates will present a challenge to education. Education must move away from the discourse of skills and towards the discourse of meaning and motivation. The paper considers three kinds of non-waged optional labor that may form the basis of the future economy: prosumption, volunteering, and self-design. All three require the ability of a worker to make meaning of his or her own life.

Branden Fitelson and Alan Hájek have suggested that it is finally time for a “revolution” in which we jettison Kolmogorov’s axiomatization of probability, and move to an alternative like Popper’s. According to these authors, not only did Kolmogorov fail to give an adequate analysis of conditional probability, he also failed to give an adequate account of another central notion in probability theory: probabilistic independence. This paper defends Kolmogorov, with a focus on this independence charge. I show that Kolmogorov’s sophisticated theory (...) of conditional distributions, advocated by authors such as Kenny Easwaran but often overlooked by philosophers, has the resources to define the notion of independence Fitelson and Hájek seek. I then argue that Kolmogorov’s original definition of independence, once suitably reinterpreted as capturing a slight logical weakening of this notion, is not so problematic after all. Indeed, rather than discarding Kolmogorov’s definition, we should make room for two distinct notions of probabilistic independence, one stronger and one weaker, which play different theoretical roles. (shrink)

Supervised machine learning has found its way into ever more areas of scientific inquiry, where the outcomes of supervised machine learning applications are almost universally classified as predictions. I argue that what researchers often present as a mere terminological particularity of the field involves the consequential transformation of tasks as diverse as classification, measurement, or image segmentation into prediction problems. Focusing on the case of machine-learning enabled poverty prediction, I explore how reframing a measurement problem as a prediction task alters (...) the primary epistemic aim of the application. Instead of measuring a property, machine learning developers conceive of their models as predicting a given measurement of this property. I argue that this _predictive reframing_ common to supervised machine learning applications is epistemically and ethically problematic, as it allows developers to externalize concerns critical to the epistemic validity and ethical implications of their model’s inferences. I further hold that the predictive reframing is not a necessary feature of supervised machine learning by offering an alternative conception of machine learning models as measurement models. An interpretation of supervised machine learning applications to measurement tasks as _automatically-calibrated model-based measurements_ internalizes questions of construct validity and ethical desirability critical to the measurement problem these applications are intended to and presented as solving. Thereby, this paper introduces an initial framework for exploring technical, historical, and philosophical research at the intersection of measurement and machine learning. (shrink)

Procrastination refers to voluntarily postponing an intended course of action despite expecting to be worse off for this delay, and students are considered to be especially negatively affected. According to estimates in the literature, at least half of the students believe procrastination impacts their academic achievements and well-being. As of yet, evidence-based ideas on how to differentiate severe from less severe cases of procrastination in this population do not exist, but are important in order to identify those students in need (...) of support. The current study recruited participants from different universities in Sweden to participate in an anonymous online survey investigating self-rated levels of procrastination, impulsivity, perfectionism, anxiety, depression, stress, and quality of life. Furthermore, diagnostic criteria for pathological delay as well as self-report items and open-ended questions were used to determine the severity of their procrastination and its associated physical and psychological issues. In total, 732 participants completed the survey. A median-split on the Pure Procrastination Scale and the responses to the PDC were used to differentiate two groups; “less severe procrastination”, and “severe procrastination”. For participants in the severe group, 96–97% considered procrastination to a problem, compared to 42–48% in the less severe group. The two groups also differed with regard to considering seeking help for procrastination, 35–38% compared to 5–7%. Participants in the severe group also reported more problems of procrastination in different life domains, greater symptoms of psychological issues, and lower quality of life. A thematic analysis of the responses on what physical issues were related to procrastination revealed that these were characterized by stress and anxiety, e.g., tension, pain, and sleep and rest, while the psychological issues were related to stress and anxiety, but also depression, e.g., self-criticism, remorse, and self-esteem. The current study recommends the PPS to be used as an initial screening tool, while the PDC can more accurately determine the severity level of procrastination for a specific individual. (shrink)

Proponents of evidence-based medicine have argued convincingly for applying this scientific method to medicine. However, the current methodological framework of the EBM movement has recently been called into question, especially in epidemiology and the philosophy of science. The debate has focused on whether the methodology of randomized controlled trials provides the best evidence available. This paper attempts to shift the focus of the debate by arguing that clinical reasoning involves a patchwork of evidential approaches and that the emphasis on evidence (...) hierarchies of methodology fails to lend credence to the common practice of corroboration in medicine. I argue that the strength of evidence lies in the evidence itself, and not the methodology used to obtain that evidence. Ultimately, when it comes to evaluating the effectiveness of medical interventions, it is the evidence obtained from the methodology rather than the methodology that should establish the strength of the evidence. (shrink)

I respond to Vaidman’s recent criticisms of my paper “A New Problem for Quantum Mechanics”.

The origin of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the subject of many hypotheses. One of them, proposed by Segreto and Deigin, assumes artificial chimeric construction of SARS‐CoV‐2 from a backbone of RaTG13‐like CoV and receptor binding domain (RBD) of a pangolin MP789‐like CoV, followed by serial cell or animal passage. Here we show that this hypothesis relies on incorrect or weak assumptions, and does not agree with the results of comparative genomics analysis. The genetic divergence between SARS‐CoV‐2 (...) and both its proposed ancestors is too high to have accumulated in a lab, given the timeframe of several years. Furthermore, comparative analysis of S‐protein gene sequences suggests that the RBD of SARS‐CoV‐2 probably represents an ancestral non‐recombinant variant. These and other arguments significantly weaken the hypothesis of a laboratory origin for SARS‐CoV‐2, while the hypothesis of a natural origin is consistent with all available genetic and experimental data. (shrink)