Incidental fndings of potential medical signifcance are seen in approximately 5-8 percent of asymptomatic subjects and 16 percent of symptomatic subjects participating in large computed tomography colonography studies, with the incidence varying further by CT acquisition technique. While most CTC research programs have a well-defned plan to detect and disclose IFs, such plans are largely communicated only verbally. Written consent documents should also inform subjects of how IFs of potential medical signifcance will be detected and reported in CTC research studies.

This study examined three main issues among 364 primary school children: (1) self?reported levels of perceived safety in classroom and playground, and relationship with teacher, (2) associations between perceived safety in the two contexts and peer reported levels of being bullied, and (3) if relationship with teacher moderated the associations between peer reported levels of being bullied and perceived safety in classroom and playground. Data were collected in individual and small group interviews. Overall, while most participants reported positive relationships with (...) their class teacher, and felt safe in their classroom and in the playground, a substantial minority did not. The correlations between level of being bullied and perceived safety in classroom and playground were significant but of modest size. Relationship with teacher did moderate the correlation for perceived safety in the classroom, but did not do so for perceived safety in the playground. No significant age or sex differences were obtained. The theoretical and practical implications of these findings were discussed. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

Proposals to make us smarter than the greatest geniuses or to add thousands of years to our life spans seem fit only for the spam folder or trash can. And yet this is what contemporary advocates of radical enhancement offer in all seriousness. They present a variety of technologies and therapies that will expand our capacities far beyond what is currently possible for human beings. In _Humanity's End,_ Nicholas Agar argues against radical enhancement, describing its destructive consequences. Agar examines (...) the proposals of four prominent radical enhancers: Ray Kurzweil, who argues that technology will enable our escape from human biology; Aubrey de Grey, who calls for anti-aging therapies that will achieve "longevity escape velocity"; Nick Bostrom, who defends the morality and rationality of enhancement; and James Hughes, who envisions a harmonious democracy of the enhanced and the unenhanced. Agar argues that the outcomes of radical enhancement could be darker than the rosy futures described by these thinkers. The most dramatic means of enhancing our cognitive powers could in fact kill us; the radical extension of our life span could eliminate experiences of great value from our lives; and a situation in which some humans are radically enhanced and others are not could lead to tyranny of posthumans over humans. (shrink)

In this provocative book, philosopher Nicholas Agar defends the idea that parents should be allowed to enhance their children’s characteristics. Gets away from fears of a Huxleyan ‘Brave New World’ or a return to the fascist eugenics of the past Written from a philosophically and scientifically informed point of view Considers real contemporary cases of parents choosing what kind of child to have Uses ‘moral images’ as a way to get readers with no background in philosophy to think about (...) moral dilemmas Provides an authoritative account of the science involved, making the book suitable for readers with no knowledge of genetics Creates a moral framework for assessing all new technologies. (shrink)

In this provocative book, philosopher Nicholas Agar defends the idea that parents should be allowed to enhance their children’s characteristics. Gets away from fears of a Huxleyan ‘Brave New World’ or a return to the fascist eugenics of the past Written from a philosophically and scientifically informed point of view Considers real contemporary cases of parents choosing what kind of child to have Uses ‘moral images’ as a way to get readers with no background in philosophy to think about (...) moral dilemmas Provides an authoritative account of the science involved, making the book suitable for readers with no knowledge of genetics Creates a moral framework for assessing all new technologies. (shrink)

Abstract:This paper considers the relevance of the concept of “eugenics,”—a term associated with some of the most egregious crimes of the twentieth century—to the possibility of editing human genomes. The author identifies some uses of gene editing as eugenics but proposes that this identification does not suffice to condemn them. He proposes that we should distinguish between “morally wrong” practices, which should be condemned, and “morally problematic” practices that call for solutions, and he suggests that eugenic uses of gene editing (...) fall into this latter category. Although when we choose the characteristics of future people we are engaging in morally dangerous acts, some interventions in human heredity should nevertheless be acknowledged as morally good. These morally good eugenic interventions include some uses of preimplantation genetic diagnosis. The author argues that we should think about eugenic interventions in the same way that we think about morally problematic interventions in public health. When we recognize some uses of gene editing as eugenics, we make the dangers of selecting or modifying human genetic material explicit. (shrink)

Comparing the ways in which the French cultural theorist Paul Virilio and the Australian cybernetic performance artist Stelarc criticize or defend technological cultural practices, this article argues that Virilio's ambiguous responses to avant-garde art highlight his key ideas far move clearly than his single-minded critique of 'termninal' mass-cultural practices - without any relationship to art - in Polar Inertia and Open Sky. Virlio's The Art of the Motor attacks the strategies of 20th-century technological avant- gardes for their apparent eugenicist and (...) fascist sympathies, but Virilios more recent interviews in Cyberrnonde and Voage d'hiver defend the ways in which the pre-technological avant-gardes resist the realist perspective of photography, and argue that the technological arts should offer similar resistance to the impact of cyberculture. Whereas Virilio concludes that such technological 'resistance' is probably impossible, Stelarc's recent research identifies exceptions to Virilio's rules. (shrink)

This paper defends the idea that there might be vagueness or indeterminacy in the world itself---as opposed to merely in our representations of the world---against the charges of incoherence and unintelligibility. First we consider the idea that the world might contain vague *properties and relations*; we show that this idea is already implied by certain well-understood views concerning the semantics of vague predicates (most notably the fuzzy view). Next we consider the idea that the world might contain vague *objects*; we (...) argue that an object is indeterminate in a certain respect (colour, size, etc.) just in case it is a borderline case of a maximally specific colour (size, etc.) property. Finally we consider the idea that the *world as a whole* might be indeterminate; we argue that the world is indeterminate just in case it lacks a determinate division into determinate objects. (shrink)

Academics from diverse disciplines are recognizing not only the procedural ethical issues involved in research, but also the complexity of everyday “micro” ethical issues that arise. While ethical guidelines are being developed for research in aboriginal populations and low-and-middle-income countries, multi-partnered research initiatives examining arts-based interventions to promote social change pose a unique set of ethical dilemmas not yet fully explored. Our research team, comprising health, education, and social scientists, critical theorists, artists and community-activists launched a five-year research partnership on (...) arts-for-social change. Funded by the Social Science and Humanities Research Council in Canada and based in six universities, including over 40 community-based collaborators, and informed by five main field projects, we set out to synthesize existing knowledge and lessons we learned. We summarized these learnings into 12 key points for reflection, grouped into three categories: community-university partnership concerns, dilemmas related to the arts, and team issues. In addition to addressing previous concerns outlined in the literature, we identified power dynamics hindering meaningful participation of community partners and university-based teams that need to be addressed within a reflective critical framework of ethical practice. We present how our team has been addressing these issues, as examples of how such concerns could be approached in community-university partnerships in arts for social change. (shrink)

David DeGrazia1 offers, to my mind, a decisive response to the bioconservative suggestion that moral bioenhancement threatens human freedom or undermines its value. In this brief commentary, I take issue with DeGrazia's way of defining MB. A different concept of MB exposes a danger missed by his analysis.Two ways to define MBDeGrazia presents MB as a form of enhancement directed at moral capacities. There are, in the philosophical literature, two broad approaches to defining human enhancement. Simplifying somewhat, one account identifies (...) enhancement with improvement. DeGrazia joins other advocates of MB in preferring this type of account, defining a human enhancement as ‘any deliberate intervention that aims to improve an existing capacity, select for a desired capacity, or create a new capacity in a human being.’1An alternative approach relativises enhancement to human norms.2 ,3 In this view, improvements up to levels of functioning properly considered normal for humans are therapy, not enhancement. Improvements beyond those levels are enhancements. The injection of synthetic erythropoietin by someone suffering from anaemia is therapy. When healthy Tour de France competitors inject EPO, it is enhancement.We can minimise philosophical disputes about word meanings by endorsing a conceptual pluralism that acknowledges the need for more than one concept of human enhancement to address the hugely varied ways in which technology may alter humans. In the debate about biomedical moral improvements there would be enhancement as improvement and enhancement beyond human norms.DeGrazia effectively deploys the concept of enhancement as improvement to …. (shrink)

1. Introduction 2. Reward-Guided Decision Making 3. Content in the Model 4. How to Deflate a Metarepresentational Reading Proust and Carruthers on metacognitive feelings 5. A Deflationary Treatment of RPEs? 5.1 Dispensing with prediction errors 5.2 What is use of the RPE focused on? 5.3 Alternative explanations—worldly correlates 5.4 Contrast cases 6. Conclusion Appendix: Temporal Difference Learning Algorithms.

This paper examines a broad range of ethical perspectives and principles relevant to the analysis of issues raised by the science of climate change and explores their implications. A second and companion paper extends this analysis to the contribution of ethics, economics and politics in understanding policy towards climate change. These tasks must start with the science which tells us that this is a problem of risk management on an immense scale. Risks on this scale take us far outside the (...) familiar policy questions and standard, largely marginal, techniques commonly used by economists; this is a subject that requires the full breadth and depth of what economics has to offer and a much more thoughtful view of ethics than economists usually bring to bear. Different philosophical approaches bring different perspectives on understanding and policy, yet they generally point to the case for strong action to manage climate change. (shrink)

Much of the focus of programs designed to promote responsible conduct in research has traditionally been on the high crimes of fabrication, falsification, and plagiarism. We believe that equally deserving of our attention are the misdemeanors that also can occur. Viewed as individual events, these “little murders” are far less serious. Yet, we believe that in the aggregate they can do great harm, not the least because they can set the stage for far greater crimes.

The distinction between literal and figurative use is well-known and embedded in ‘folk linguistics’. According to folk linguistics, figurative uses deviate from literal ones. But recent work on lexical modulation and polysemy shows that meaning deviation is ubiquitous, even in cases of literal use. Hence, it has been argued, the literal/figurative distinction has no value for theorising about communication. In this paper, we focus on metaphor and argue that here the literal–figurative distinction has theoretical importance. The distinction between literal and (...) metaphorical needs to be captured by our account of communication because literal uses transmit information in a way that metaphorical ones do not. We argue that there is a way to explain the literal/metaphorical distinction that preserves the core of the folk-linguistic idea and gives the distinction theoretical relevance. We propose that literal uses of a word are made with the intention to conform to an established practice of use, while metaphorical uses do not so conform, but depend on this pre-existing practice. Our account can deal with data that are problematic for other theories. A further advantage is that it extends naturally to other non-literal uses of words, including metonymy. (shrink)

Both intertemporal and intratemporal equity are central to the examination of policy towards climate change. However, many discussions of intertemporal issues have been marred by serious analytical errors, particularly in applying standard approaches to discounting; the errors arise, in part, from paying insufficient attention to the magnitude of potential damages, and in part from overlooking problems with market information. Some of the philosophical concepts and principles of Paper 1 are applied to the analytics and ethics of pure-time discounting and infinite-horizon (...) models, providing helpful insights into orderings of welfare streams and obligations towards future generations. Such principles give little support for the idea of discrimination by date of birth. Intratemporal issues are central to problematic and slow-moving international discussions and are the second focus of this paper. A way forward is to cast the policy issues and analyses in a way that keeps equity issues central and embeds them in the challenge of fostering the dynamic transition to the low-carbon economy in both developed and developing countries. This avoids the trap of seeing issues primarily in terms of burden-sharing and zero-sum games – that leads to inaction and the most inequitable outcome of all. (shrink)

To be committed to the truth of a proposition is to constrain one’s options in a certain way: one may not reason as if it is false, and one is obligated to reason as if it is true. Though one is often committed to the truth of the propositions that one believes, the states of belief and commitment are distinct. For historical reasons, however, they are rarely distinguished. Distinguishing between the two states allows for a defense of epistemic deontology against (...) the charge that beliefs are not under the voluntary control of believers, and so cannot be subject to deontic evaluation. It also allows for the resolution of some disputes between naturalists and non-naturalists in epistemology, and permits us to account for obvious facts about the connection between belief and truth in a theoretically parsimonious way. (shrink)

A common theme in the historiography of Greek ethics says that modern ethics is characterized by imperative notions such as ‘duty’—and with a Judeo‐Christian notion of imperatives or commands issued by god—whereas ancient ethics supposedly deals mainly with ‘attractive notions such as ‘good’ and ‘virtue’. This thought is often juxtaposed with the idea that imperative notions betoken a conflict between one's duty and one's good, because an imperative seems to be required only to command people to do what they do (...) not wish to do, which is felt to be inappropriate to the supposed eudaimonism of Greek ethics. In fact Greek ethics makes substantial use of imperative notions, and does not attempt to show that attractive notions are more basic or preferable in ethics. (shrink)

Thus far it has been shown that Greek ethics is not as different from modern ethics as is commonly held, and that we cannot oppose a harmonizing Greek ethical outlook with a modern view that involves a conflict between happiness and adherence to ethical standards. Greek ethics has universalistic features—though they are different from the egalitarian characteristics of modern positions and do not focus on the notion of benevolence in the way that modern ethics does—and it mostly distinguishes self‐referential and (...) non‐self‐referential aims. Moreover, there is not in any case such a thing as a monolithic ethical view of ‘the Greeks’, and the idea of a straightforward contrast between ‘ancient’ and ‘modern’ ethics is best avoided. (shrink)

One of the main vehicles for the reconciliation of individual and social happiness that has supposedly been characteristic of Greek ethics is the concept of the polis. In the Hegelian tradition it has been thought that the Greeks reduced all norms and values to standards laid down by and for the city‐state, and that this fact made it possible for them to hold that the well‐being of an individual is entirely compatible with the well‐being of his fellow‐citizens and of the (...) city‐state as a whole. However, the Greeks were familiar with and attached substantial weight to non‐polis‐based norms and values, even universalist ones like the Golden Rule, and made ample conceptual room for conflict between the happiness of a citizen and that of his community. Moreover, Greek attitudes on this issue were variegated, not uniform. (shrink)

Reasoning with conditionals is often thought to be non-monotonic, but there is no incompatibility with classical logic, and no need to formalise inference itself as probabilistic. When the addition of a new premise leads to abandonment of a previously compelling conclusion reached by modus ponens, for example, this is generally because it is hard to think of a model in which the conditional and the new premise are true.

Economics takes an individualistic approach to human behaviour. This is reflected in the use of 'contingent valuation' surveys to conduct cost benefit analysis for economic policy evaluation. An individual's valuation of a policy is assumed to be unaffected by the burdens it places on others. We report a survey experiment to test this supposition in the context of climate change policy. Willingness to pay for climate change mitigation was higher when richer individuals were to bear higher costs than when, as (...) is usual, no explicit information was provided about cost distribution. This result is inconsistent with the usual interpretation of contingent valuation data. It also suggests that the data may be biased indicators of policy acceptance. Additional survey questions suggest that a collective mode of reasoning is common. (shrink)

This introductory article is structured around the following themes: it begins with a brief overview of some important works that have paved the way for the present discussion. This is followed by a critique of the concept of “experience” and the philosophies based on it, that was first presented by feminist thinkers Joan Scott and Judith Butler in the 1980’s. The question this debate poses to the discussions in this book is whether focusing on experience is still a philosophically viable (...) option. After that, the views of Edmund Husserl – often described as “the father of phenomenology” – are presented on the particular themes of motherhood and pregnancy, as it is often overlooked that he had anything to say on the topic. Then follows a short outline of the structure of the experience of pregnancy, and also the modest suggestion that pregnancy should be seen not only as “split subjectivity” but also as a specific mode of phenomenological “in-between.” Thereafter the question is taken up whether pregnancy as a philosophical topic might also affect the methodological core of phenomenology. The article ends with a speculative outlook towards certain themes that have developed as a consequence of thinking pregnancy philosophically. (shrink)

There is a debate about the possibility of mind-uploading – a process that purportedly transfers human minds and therefore human identities into computers. This paper bypasses the debate about the metaphysics of mind-uploading to address the rationality of submitting yourself to it. I argue that an ineliminable risk that mind-uploading will fail makes it prudentially irrational for humans to undergo it.

Aesthesis, the classical term for sensing and perceiving, is at the heart of innumerable problems that plague global society. The purpose of this article is to open a conversation on aesthesis. We survey the roots and relevance of aesthesis as a direct albeit contested relation and engagement with the world and with Others. From its pre-Socratic origins, aesthesis has been both a pragmatic, somatic concept, prompting a re-evaluation of the distinction between experience and abstraction. We trace its ongoing repression from (...) Plato through ‘western’ theories of formal Aesthetics. Drawing on a relational interpretation of Protagoras’ aesthesis, we argue that modern pragmatists and radical empiricists, as well as more contemporary critics of the ‘colonization’ of aesthesis (Mignolo and Vasquez) by formal Aesthetics recognize and develop the relational and ethical aspects of aesthesis. We consider the role of the body, affect, and of the intangible or virtual qualities of aesthesis. The ethics of obligations (Weil) in the polis (Arendt) shows how aesthesis informs politics despite its repression in favour of moral and legal norms. We argue this is relevant to contemporary crises such as xenophobia and ecocidal climate warming. (shrink)

There is increasing evidence for epigenetically mediated transgenerational inheritance across taxa. However, the evolutionary implications of such alternative mechanisms of inheritance remain unclear. Herein, we show that epigenetic mechanisms can serve two fundamentally different functions in transgenerational inheritance: (i) selection-based effects, which carry adaptive information in virtue of selection over many generations of reliable transmission; and (ii) detection-based effects, which are a transgenerational form of adaptive phenotypic plasticity. The two functions interact differently with a third form of epigenetic information transmission, (...) namely information about cell state transmitted for somatic cell heredity in multicellular organisms. Selection-based epigenetic information is more likely to conflict with somatic cell inheritance than is detection-based epigenetic information. Consequently, the evolutionary implications of epigenetic mechanisms are different for unicellular and multicellular organisms, which underscores the conceptual and empirical importance of distinguishing between these two different forms of transgenerational epigenetic effect. (shrink)

This article provides a speech act analysis of ‘crime-enacting’ provisions in criminal statutes, focusing on the illocutionary force of these provisions. These provisions commonly set out not only particular crimes and their characteristics but also their associated penalties. Enactment of a statute brings into force new social facts, typically norms, through the official utterance of linguistic material. These norms are supposed to guide behaviour: they tell us what we must, may, or must not do. Our main claim is that the (...) illocutionary force of such provisions is primarily ‘world-creating’, i.e. effective, or declarational, rather than directive. We assume that directive illocutionary force is either direct or indirect, showing that provisions need not contain the linguistic items that make for direct directives and that according to standard tests no indirect directive is present. A potential counter-argument is that any utterance serving to direct behaviour is necessarily a directive. We show that this behaviour-directing property is shared by some clear non-directives. (shrink)

The article enters a heated debate about the ideals and organization of the postmodern left. Hardt and Negri, two key figures in this debate, claim that their concept of the multitude — a revolutionary, proletarian body that organizes singularities — integrates the insights of Deleuze and Lenin. I argue, however, that Deleuze anticipated and resisted a Leninist appropriation of his political theory. This essay challenges the widely accepted assumption that Hardt and Negri carry forth Deleuze’s legacy. At the same time, (...) the essay advocates Deleuze’s concept of left assemblages — protean political bodies working for freedom and equality — as a valuable but underappreciated contribution to the liberal-democratic tradition. (shrink)

Fodor’s radical concept nativism flowed from his view that hypothesis testing is the only route to concept acquisition. Many have successfully objected to the overly-narrow restriction to learning by hypothesis testing. Existing representations can be connected to a new representational vehicle so as to constitute a sustaining mechanism for a new representation, without the new representation thereby being constituted by or structured out of the old. This paper argues that there is also a deeper objection. Connectionism shows that a more (...) fundamental assumption underpinning the debate can also be rejected: the assumption that the development of a new representation must be explained in content-involving terms if innateness is to be avoided. -/- Fodor has argued that connectionism offers no new resources to explain concept acquisition: unless it is merely an uninteresting claim about neural implementation, connectionism’s defining commitment to distributed representations reduces to the claim that some representations are structured out of others (which is the old, problematic research programme). Examination of examples of representational development in connectionist networks shows, however, that some such models explain the development of new representational capacities in non-representational terms. They illustrate the possibility of representational development that is not explicable-by-content. Connectionist representations can be distributed in an important sense, which is incompatible with the assumption of explanation-by-content: they can be distributed over non-representational resources that account for their development. Rejecting the assumption of explanation-by-content thereby opens up a more radical way of rejecting Fodor’s argument for radical concept nativism. (shrink)