Panenmentalist possibilities are individual pure possibilities existing independently of any mind, actual reality, and possible-world conception. These possibilities are a priori accessible to our intellect and imagination. In this paper, I attempt to shed some panenmentalist light on the discovery of chemical branched chain reactions and its implications on biology and cancer research. I also examine the case of the Belousov–Zhabotinsky reaction which, at first, was believed to be impossible. Finally, I proceed to examine through a panenmentalist (...) lens Szilard’s discovery of the possibility of physical chain reactions and Mullis’s discovery of a polymerase chain reaction. All these major actual discoveries clearly depend on the discovery of the relevant panenmentalist possibilities and the ways in which they relate to one another. (shrink)

A history of the Atomic Bomb from Marie Curie to Hiroshima. “I am become Death, the destroyer of worlds” — Oppenheimer quoting the Bhagavad Gita after witnessing the successful demonstration of the atom bomb. The bomb, which killed an estimated 140,000 civilians in Hiroshima and destroyed the countryside for miles around, was one of the defining moments in world history. That mushroom cloud cast a terrifying shadow over the contemporary world and continues to do so today. But how could this (...) have happened? What led to the creation of such a weapon of mass destruction? From the moment scientists contemplated the destructive potential of splitting the atom, the role of science changed. Ethical and moral dilemmas faced all those who realized the implications of their research. Before the Fall-Out charts the chain of events from Marie Curie’s scientific breakthrough through the many colourful characters such as Einstein, Robert Oppenheimer and Lord Rutherford, whose discoveries contributed to the bomb. The story of the atomic bomb spans 50 years of prolific scientific innovation, turbulent politics, foreign affairs and world-changing history. Through personal stories of exile, indecision and soul-searching, to charges of collaboration, spying and deceit, Diana Preston presents the human side of an unstoppable programme with a lethal outcome. (shrink)

Christian Wilhelm Blomstrand, Professor of Chemistry and Mineralogy at Lund University from 1862 to 1895, was one of the important chemists of the second half of the nineteenth century. His theoretical ideas and experimental accomplishments contributed to advances in several branches of chemistry. Living in Sweden during a transitional period between the older and newer chemistry and being a scientific as well as a political conservative, Blomstrand sought to reconcile Berzelius's dualistic theory with the unitary and type theories. He was (...) opposed to Kekulé's dogma of constant valency, and he strove to establish a sound and complete theory of variable valency. This article briefly outlines Blomstrand's life and considers his best known book, Die Chemie der Jetztzeit , as well as his work on mineralogy, inorganic chemistry , and his theoretical views on valency, diazo compounds, and metal-ammines. His so-called ‘chain theory’, as developed and modified by his fellow Scandinavian chemist and close friend, Sophus Mads Jørgensen, was for more than three decades the most popular and successful of the numerous attempts to explain the constitution, properties, and reactions of coordination compounds. (shrink)

We consider a chain of metabolic reactions catalyzed by enzymes, of reversible Michaelis-Menten type with full dynamics, i.e. not reduced with any quasi-steady state approximations. We study the corresponding dynamical system and show its global stability if the equilibrium exists. If the system is open, the equilibrium may not exist. The main tool is monotone systems theory. Finally we study the implications of these results for the study of coupled genetic-metabolic systems.

The paper is devoted to an approach to analytic tableaux for propositional logic, but can be successfully extended to other logics. The distinguishing features of the presented approach are:(i) a precise set-theoretical description of tableau method; (ii) a notion of tableau consequence relation is defined without help of a notion of tableau, in our universe of discourse the basic notion is a branch;(iii) we define a tableau as a finite set of some chosen branches which is enough to check; hence, (...) in our approach a tableau is only a way of choosing a minimal set of closed branches;(iv) a choice of tableau can be arbitrary, it means that if one tableau starting with some set of premisses is closed in the defined sense, then every branch in the power set of the set of formulas, that starts with the same set, is closed. (shrink)

Nitric oxide (NO) is involved in synaptic long-term potentiation (LTP) by multiple signaling pathways. Here, we show that LTP of synaptic transmission can be explained as a feature of signal transduction—bistable behavior in a chain of biochemical reactions with positive feedback, formed by diffusion of NO to the presynaptic site and facilitating the release of glutamate (Glu). The dynamics of Glu, calcium (Ca2+) and NO is described by a system of nonlinear reaction–diffusion equations with modified Michaelis–Menten (MM) kinetics. (...) Numerical investigation reveals that the chain of biochemical reactions analyzed can exhibit a bistable behavior under physiological conditions when production of Glu is described by MM kinetics and decay of NO is modeled by means of two enzymatic pathways with different kinetic properties. Our finding extends understanding of the role of NO in LTP: a short high-intensity stimulus is “memorized” as a long-lasting elevation of NO concentration. The conclusions obtained by analysis of the chain of biochemical reactions describing LTP can be generalized to other chains of interactions or for creating the logical elements for biological computers. (shrink)

Let κ be a singular cardinal. Karp's notion of a chain model of size κ is defined to be an ordinary model of size κ along with a decomposition of it into an increasing union of length cf. With a notion of satisfaction and -isomorphism such models give an infinitary logic largely mimicking first order logic. In this paper we associate to this logic a notion of a dynamic EF-game which gauges when two chain models are chain-isomorphic. (...) To this game is associated a tree which is a tree of size κ with no κ-branches -branches). The measure of how non-isomorphic the models are is reflected by a certain order on these trees, called reduction. We study the collection of trees of size κ with no κ-branches under this notion and prove that when cf = ω this collection is rather regular; in particular it has universality number exactly κ+. Such trees are then used to develop a descriptive set theory of the space cf κ. The main result of the paper gives in the case of κ strong limit singular an exact connection between the descriptive set-theoretic complexity of the chain isomorphism orbit of a model, the reduction order on the trees and winning strategies in the corresponding dynamic EF games. In particular we obtain a neat analog of the notion of Scott watershed from the Scott analysis of countable models. (shrink)

In the metabolic control theory, the control coefficient is a key parameter in quantifying the sensitivity of the flux towards an infinitesimal variation of enzyme activity. This concept does not apply just as it is for variations of enzyme concentrations whenever there is spatial, energy or resources limitations in the cell. Due to constraint on total enzyme concentration, the variation of concentration of any given enzyme may affect the concentrations of other enzymes. To take into account these correlations between enzyme (...) concentrations, we propose the concept of "combined response coefficient". Its definition is similar to that of the control coefficient, but its mathematical expression is different. Its range of variation is from – + 1, the null value corresponding to optimum enzyme concentration, i.e. to concentrations that maximise the flux, and the negative values to concentrations beyond the optimum value. A summation property could be derived using a simple weighting of the combined response coefficients, the sum of the weighed coefficient being 0. (shrink)

The only RNA molecules known to be branched are circular structures with tails known as lariats that arise during nuclear pre‐mRNA splicing. Lariats accumulate within a large multicomponent particle called a spliceosome that forms upon the addition of unspliced mRNA to nuclear extracts. Recently an RNA molecule has been observed to catalyze branch formation. In this case a single intron of a yeast mitochondrial pre‐mRNA participates in a self‐splicing reaction that results in the accumulation of branched lariats that (...) are processed to correctly spliced exons.An enzyme highly specific for branch removal found in the same extracts that form branches during pre‐mRNA splicing can debranch RNA lariats to their linear forms without loss of nucleotides.The chemical synthesis of branched RNA has recently been achieved. High yields of sequence‐specific oligonucleotides are now available for the analysis of RNA splicing by techniques dependent on branch‐site recognition. (shrink)

Recent discussions in the philosophy of science have devoted considerable attention to the analysis of conceptual issues relating to the methodology of explanation and prediction in the sciences. Part of this literature has been devoted to clarifying the very ideas of explanation and prediction. But the discussion has also ranged over various related topics, including the status of laws to be used for explanatory and predictive purposes, the logical interrelationships between explanatory and predictive reasonings, the differences in the strategy of (...) explanatory argumentation in different branches of science, the nature and possibility of teleological explanation, etc. The aim of the present article is to examine the issues involved in such questions from the specialized perspective afforded by one particular kind of physical systems--namely, systems, here to be characterized as discrete state systems, whose behavior has been studied extensively in the scientific literature under the general heading of Markov chains. These systems have been chosen as our focus because their behavior over time can be analyzed at once with great ease and with extraordinary precision. (shrink)

Biological forms are very complex, and mechanisms of pattern formation are not well understood. Although developmental biology deals with the mechanistic explanation of patterns, currently we do not know how to understand the mechanisms of pattern formation from huge amounts of molecular information. In this article, I present one useful tool, mathematical modeling, to obtain a mechanistic understanding of biological pattern formation, and show an actual example in lung branching morphogenesis. In this example, mathematical modeling plays an indispensable role in (...) understanding the biological phenomena. The model successfully reproduces the basic features of morphogenesis in vitro, but mechanism in vivo still remains to be elucidated. (shrink)

The COVID-19 pandemic spread catastrophically over the world since the spring of 2020. In this paper, a heterogeneous branching process with immigration is established to quantify the human-to-human transmission of COVID-19 in local communities, based on the temporal and structural transmission patterns extracted from public case disclosures by four provincial Health Commissions in China. With proper parameter settings, our branching model matches the actual transmission chains satisfactorily and, therefore, sheds light on the underlying COVID-19 spreading mechanism. Moreover, based on our (...) branching model, the efficacy of home quarantine and social distancing are explored, providing a reference for the effective prevention of COVID-19 worldwide. (shrink)

This article examines non-statutory executive powers, which are commonly employed in the modern state but rarely studied as a distinct concept. The article assesses three treatments of these powers available in current English public law—prerogative, common law powers which rely on analogies between the state and legal persons, and judicial review—and argues that they fail to provide a proper balance between legality and need. Royal prerogative connotes a shrinking reservoir of ancient powers, while non-statutory powers respond to unexpected futures and (...) statute’s intrinsic eventual failings. Analogies to legal persons fail to address the particularities of executive powers. Judicial review provides only a partial solution, since absence of parliamentary approval is not, in itself, ground for special treatment of executive action. The author joins calls for theoretization of public law and advances a model of executive powers that draws on a composite theory of the executive branch and its functions.This article examines non-statutory executive powers, which are commonly employed in the modern state but rarely studied as a distinct concept. The article assesses three treatments of these powers available in current English public law—prerogative, common law powers which rely on analogies between the state and legal persons, and judicial review—and argues that they fail to provide a proper balance between legality and need. Royal prerogative connotes a shrinking reservoir of ancient powers, while non-statutory powers respond to unexpected futures and statute’s intrinsic eventual failings. Analogies to legal persons fail to address the particularities of executive powers. Judicial review provides only a partial solution, since absence of parliamentary approval is not, in itself, ground for special treatment of executive action. The author joins calls for theoretization of public law and advances a model of executive powers that draws on a composite theory of the executive branch and its functions. (shrink)

This chapter focuses on one of the common fallacies in Western philosophy called the slippery slope. According to Patrick Hurley in A Concise Introduction to Logic, “the fallacy of slippery slope is a variety of the false cause fallacy. It occurs when the conclusion of an argument rests on an alleged chain reaction and there is not sufficient reason to think that the chain reaction will actually take place”. The key term in the chapter is “chain reaction”. (...) If all of the events in the chain reaction can be justified, then the slippery slope is not committed. But the nuances and intricate improbable connections between each event still make it difficult to support the ultimate conclusion, which is to get rid of cable. The chapter discusses two simple techniques in order to avoid committing the slippery slope fallacy. (shrink)

In this study, we examine investor and firm response to the California Transparency in Supply Chains Act of 2010. The CTSCA requires large retail and manufacturing firms to disclose efforts to eradicate slavery and human trafficking from their supply chains and is a rare example of mandated corporate social responsibility disclosure. Based on a sample of 105 retail companies subject to the CTSCA, we find a significant negative market reaction to the passing of the CTSCA. Furthermore, we find that the (...) reaction is significantly more negative for larger firms and companies facing greater supply chain risks, suggesting that investors place a negative value on exposure to legitimacy threats in the social domain. With respect to company disclosure response, we document relatively high compliance with the legislation, although we also find that the disclosure response appeared to be more symbolic than substantive in nature. Finally, our analysis indicates that both disclosure choice and disclosure extensiveness were significantly higher for the high-supply chain risk companies, suggesting that the response was influenced by concerns with strategic legitimation. Overall, the limited quality of disclosure suggests that, without additional rules and guidance, mandates alone may not lead to meaningful social disclosure. (shrink)

We provide a formally rigorous framework for integrating singular causation, as understood by Nuel Belnap's theory of causae causantes, and objective single case probabilities. The central notion is that of a causal probability space whose sample space consists of causal alternatives. Such a probability space is generally not isomorphic to a product space. We give a causally motivated statement of the Markov condition and an analysis of the concept of screening-off. 1. Causal dependencies and probabilities1.1Background: causation in branching space-times1.2What are (...) probabilities defined for?2. Basic transitions2.1Basics of basic transitions2.2Sets of basic transitions3. Causal probability theory3.1Some simple cases3.2General causal probabilities3.3Application: probability of suprema of a chain. (shrink)

Illustrations: 1 B/w Illustration Description: Pranab Kumar Sen, Professor Emeritus, Jadavpur University in whose honour this volume has been prepared was one of the leading philosophers of our country and a highly respected teacher. It carries thirty-five articles which deal with different branches of philosophy,viz., philosophical logic, philosophy of language, ontology, theory of knowledge, Kant exegesis, moral philosophy, social philosophy, philosophy of art. As Sen's philosophical interests and expertise were wide the authors had ample freedom in their choice of topics. (...) This volume will be of interest to those who are acquainted with sophisticated literature in analytic philosophy, scholars working in different branches of philosophy and also general readers of modern philosophy. (shrink)

Il est essentiel pour une chaîne de télévision, qu'elle soit publique ou privée, de connaître son public. Le groupe Francetélévisions s'est doté d'une direction d'études commune et de trois directions affiliées à chaque chaîne pour regrouper et analyser l'ensemble des données disponibles sur l'auditoire de la télévision. Face à la variété des outils et à la profusion des données, il est primordial de bien sélectionner ce qui est le plus pertinent pour répondre aux demandes des responsables de programme et de (...) programmation. La direction des études décortique les résultats d'audience par cible et utilise les logiciels permettant de suivre les flux de publics, les reports d'une chaîne à l'autre, etc. Les études qualitatives sont indispensables pour anticiper les réactions du public, pour améliorer un programme. Des sondages proposés par des instituts spécialisés complètent ces études internes .It is essential for both public and private television channels to know their audience. The France Télévisions group has set up a central research department covering each of its channels which also have their own individual research departments whose aim is to assemble and analyse all available audience data. Given the variety of tools and the large amount of data available, it is imperative to select well that which is the most relevant to answer demands coming from programme planners. The research and study department analyses audience ratings per target and uses software to follow audience movement, changes from one channel to another and so forth. Qualitative studies are essential to foresee audience reactions and to improve a program. Surveys proposed by specialised institutes complete these internal studies. (shrink)

permits a sound and rigorously definable notion of ‘originating cause’ or causa causans—a type of transition event—of an outcome event. Mackie has famously suggested that causes form a family of ‘inus’ conditions, where an inus condition is ‘an insufficient but non-redundant part of an unnecessary but sufficient condition’. In this essay the needed concepts of BST theory are developed in detail, and it is then proved that the causae causantes of a given outcome event have exactly the structure of a (...) set of Mackie inus conditions. The proof requires the assumption that there is no EPR-like ‘funny business’. This seems enough to constitute a theory of ‘causation’ in at least one of its many senses. Introduction The cement of the universe Preliminaries 3.1 First definitions and postulates 3.2 Ontology: propositions 3.3 Ontology: initial events 3.4 Ontology: outcome events 3.5 Ontology: transition events 3.6 Propositional language applied to events Causae causantes 4.1 Causae causantes are basic primary transition events 4.2 Causae causantes of an outcome chain 4.3 No funny business Causae causantes and inns and inus conditions 5.1 Inns conditions of outcome chains: not quite 5.2 Inns conditions of outcome chains 5.3 Inns conditions of scattered outcome events 5.4 Inus conditions for disjunctive outcome events 5.5 Inns and inus conditions of transition events Counterfactual conditionals Appendix: Tense and modal connectives in BST. (shrink)

We consider metabolic networks with reversible enzymatic reactions. The model is written as a system of ordinary differential equations, possibly with inputs and outputs. We prove the global stability of the equilibrium , using techniques of monotone systems and compartmental matrices. We show that the equilibrium does not always exist. Finally, we consider a metabolic system coupled with a genetic network, and we study the dependence of the metabolic equilibrium with respect to concentrations of enzymes. We give some conclusions (...) concerning the dynamical behavior of coupled genetic/metabolic systems. (shrink)

There are three sentimental centres of 20th-century philosophical geography: Todtnauberg, Frankfurt and Vienna. Their exceptional status results not only from having given rise to decisive philosophical movements but also from the weight of stories about victimization and exile lacking with regard to Paris, Berkeley and Cambridge. Each of these centres is compromised in its own way: the Schwarzwald cottage from which Heidegger emerged to take over the Rektorat of Freiburg University and to which he returned after this disastrous intermezzo, the (...) "Institut für Sozialforschung" which on its part returned to claim moral authority at a location that increasingly turned into the most important bridgehead of transatlantic logistics, finally the former imperial city where traces of the origins of analytic philosophy were only conserved beneath the enormous sedimentation of a massive counter-reformation. Provincialism, NATO and tourism turned out to be perfectly compatible with remembrance of an heroic epoch at these sites while exiting philosophical work was being done at different locations. How much weight is carried by impressions like these? Not too much as long as well defined philosophical schools promote progress as defined within their own realm. Some doctrin, established all over the world does not depend on the place at which it is further refined. It is, however, in doubt whether philosophy counts among the disciplines so easily internationalized; Heidegger and Adorno being among those who would insist on the inseparability of a theory's fate and its place of origin. Be this as it may, my subject being the precarious relationship between the city and the Circle of Vienna I have to start from the assumption of obvious incomparability between the roots and the extension of the branches of the movement. Only a decade ago this would have presented itself as a fairly easy task. Historians were coming to this city to save the remnants of the beginnings of the movement whereas Anglo-American philosophers were busy refining the orthodoxy and hardly interested in historical matters. Much has changed since. Firstly the analytic enterprise is in certain ways approaching what can be called closure from within.gif Secondly Austrian universities have (with sometimes considerable delay) taken an interest in what is felt to be a lost opportunity.gif Both of these developments coincided with a more general renaissance of fin de siecle and modernist Vienna. Since the imminent conclusion of any movement reactualizes the circumstances of its beginning, renewed attention was drawn to what was happening within and to the Vienna Circle. (shrink)

Purpose: This study is aimed to preliminary investigate whether transcranial alternating current stimulation could affect explosive power considering genetic background in sport subjects.Methods: Seventeen healthy sports volunteers with at least 3 years of sports activities participated in the experiment. After 2 weeks of familiarization performed without any stimulation, each participant received either 50 Hz-tACS or sham-tACS. Before and after stimulation, subjects performed the following tests: the squat jump with the hands on the hips ; countermovement jump with the hands on (...) the hips ; countermovement jump with arm swing ; 15-s Bosco’s test; seated backward overhead medicine ball throw ; seated chest pass throw with a 3-kg rubber medicine ball; and hand-grip test. Additionally, saliva samples were collected from each participant. Genotyping analysis was carried out by polymerase chain reaction.Results: No significant differences were found in sport performance of subjects after 50 Hz-tACS. Additionally, we did not find any influence of genetic background on tACS-related effect on physical performance. These results suggest that tACS at gamma frequency is not able to induce an after-effect modulating sport performance. Further investigations with larger sample size are needed in order to understand the potential role of non-invasive brain stimulation techniques in motor performances.Conclusions: Gamma-tACS applied before the physical performance fails to improve explosive power in sport subjects. (shrink)

The ongoing coronavirus 2019 pandemic caused by the severe acute respiratory syndrome coronavirus 2 has resulted in a severe ramification on the global healthcare system, principally because of its easy transmission and the extended period of the virus survival on contaminated surfaces. With the advances in computer-aided diagnosis and artificial intelligence, this paper presents the application of deep learning and adversarial network for the automatic identification of COVID-19 pneumonia in computed tomography scans of the lungs. The complexity and time limitation (...) of the reverse transcription-polymerase chain reaction swab test makes it disadvantageous to depend solely on as COVID-19’s central diagnostic mechanism. Since CT imaging systems are of low cost and widely available, we demonstrate that the drawback of the RT-PCR can be alleviated with a faster, automated, and reduced contact diagnostic process via the use of a neural network model for the classification of infected and noninfected CT scans. In our proposed model, we explore the benefit of transfer learning as a means of resolving the problem of inadequate dataset and the importance of semisupervised generative adversarial network for the extraction of well-mapped features and generation of image data. Our experimental evaluation indicates that the proposed semisupervised model achieves reliable classification, taking advantage of the reflective loss distance between the real data sample space and the generated data. (shrink)

Current methods of forensic DNA profiling, based on Polymerase Chain Reaction amplifications of a varying number of Short Tandem Repeat loci found at different locations on the human genome, are regularly described as constituting the “gold standard for identification” in contemporary society. At a time when criminal justice systems in Europe and North America increasingly seek to utilize the epistemic authority of a variety of sciences in support of the apprehension and prosecution of suspects and offenders, genetic science and (...) recombinant DNA technology are often singled out for particular approbation. Indeed, the development and application of DNA profiling has been widely described as the “greatest breakthrough in forensic science since fingerprinting.”. (shrink)

Since digital forensics becomes more and more popular, more and more attention has been paid to the originality and validity of data, and data preservation technology emerges as the times require. However, the current data preservation models and technologies are only the combination of cryptography technology, and there is a risk of being attacked and cracked. And in the process of data preservation, human participation is also needed, which may lead to data tampering. To solve problems given, this paper presents (...) a data preservation model based on blockchain and multidimensional hash. With the decentralization and smart contract characteristics of blockchain, data can be automatically preserved without human participation to form a branch chain of custody in the unit of case, and blockchain has good antiattack performance, which is the so-called 51% attack. Meanwhile, in order to solve the problem of data confusion and hard to query caused by the excessive number of cases, hash, cryptography, and timestamps are used to form a serialized main chain of custody. Because of the confliction problem of hash and judicial trial needs to absolutely guarantee the authenticity and validity of data, multidimensional hash is used to replace regular hash. In this way, the data preservation becomes an automatic, nonhuman-interventional process. Experiments have been carried out to show the security and effectiveness of the proposed model. (shrink)

A crucial part of the knowledge of molecular biologists is procedural knowledge, that is, knowledge of how to do things in laboratories. Procedural knowledge of molecular biologists involves both perceptual-motor skills and cognitive skills. We discuss such skills required in performing the most commonly used molecular biology techniques, namely, Polymerase Chain Reaction and gel electrophoresis. We argue that procedural knowledge involved in performing these techniques is more than just knowing their protocols. Creative exploration and experience are essential for the (...) acquisition of procedural knowledge in molecular biology. With enough experience, molecular biologists make intuitive judgments without recourse to analytical reasoning. We propose that procedural knowledge is intuitive recognition of the patterns of one's environment that are the most relevant for making a decision or acting appropriately. Finally, we argue that knowledge of molecular biologists requires an integration of procedural knowledge and propositional knowledge. (shrink)

Due to the COVID-19 outbreak, a series of chain reactions, like international trade breakdown, stock market collapse, and crude oil's collapse, have adversely affected the global economy, particularly small and medium-sized enterprises. As a result, the Chinese government issued many fiscal and financial policies to support SMEs. This paper analyzes SMEs' coping methods and conceptual changes affected by the epidemic and distinguishes “victims” and “beneficiaries.” Subsequently, based on extensive international experience and local government experience, it provides effective suggestions (...) for the Chinese government to deal with the post-epidemic era's economic changes, policy suggestions, and coping strategies for SMEs' short-term and long-term sustainable development. (shrink)

Mass testing is one COVID-19 pandemic response strategy. The effect of population-wide testing programs is influenced by public attitudes toward COVID-19 viral tests. However, the public’s attitudes toward mass testing and related factors in mainland China are not adequately understood. This study focuses on pandemic responses during the first wave of the Delta variant outbreak in southern China and explores how residents responded to population-wide mass COVID-19 testing programs. The research relies on data collected from short videos recording residents’ experiences (...) of being in lockdown, media reports, and semi-structured interviews. Thematic analysis was used to analyze the data, and four themes emerged: public attitudes toward mass testing, the technology of viral tests, policy and governance, and cultural practices. The study finds that residents actively participated in mass testing campaigns as mass viral tests are associated with hope and trust. The Reverse Transcription–Polymerase Chain Reaction (RT-PCR), negative test results, lockdown policies, waiting times, medical staff, and media representations are all actors that assemble and mobilize hope and trust. The research reveals some critical factors influencing people’s attitudes toward mass testing policies in response to COVID-19 and provides practical suggestions for public health professionals in rolling out effective population-wide mass COVID-19 testing. (shrink)

We investigate the epistemological consequences of a positive polymerase chain reaction SARS-CoV test for two relevant hypotheses: V is the hypothesis that an individual has been infected with SARS-CoV-2; C is the hypothesis that SARS-CoV-2 is the cause of flu-like symptoms in a given patient. We ask two fundamental epistemological questions regarding each hypothesis: First, how much confirmation does a positive test lend to each hypothesis? Second, how much evidence does a positive test provide for each hypothesis against its (...) negation? We respond to each question within a formal Bayesian framework. We construe degree of confirmation as the difference between the posterior probability of the hypothesis and its prior, and the strength of evidence for a hypothesis against its alternative in terms of their likelihood ratio. We find that test specificity—and coinfection probabilities when making inferences about C—were key determinants of confirmation and evidence. Tests with 8) for V against ¬V regardless of sensitivity. Accordingly, low specificity tests could not provide strong evidence in favor of C in all plausible scenarios modeled. We also show how a positive influenza A test disconfirms C and provides weak evidence against C in dependence on the probability that the patient is influenza A infected given that his/her symptoms are not caused by SARS-CoV-2. Our analysis points out some caveats that should be considered when attributing symptoms or death of a positively tested patient to SARS-CoV-2. (shrink)

What's Next? Michael Crichtons und Mikhail Bulgakovs Kritik der Fetischisierung in den Lebenswissenschaften. Dieser Beitrag wurde angeregt durch den Thriller Next (2006) von Michael Crichton. Im Gegensatz zu dessen State of Fear (2004), wo die Behandlung eines aktuellen wissenschaftspolitischen Problems – des Klimawandels – mit einer harschen Kritik am Umgang politischer Aktivisten mit wissenschaftlichen Ergebnissen einhergeht, setzt Next Hoffnungen und Ängste ins Zentrum, die im Zusammenhang mit dem ‚Human Genome Project‘ verhandelt wurden. Crichton stellt hier wissenschaftlich‐ökonomische Verflechtungen dar, vor denen (...) er schon in seinen Romanen zu Jurassic Park (1990) warnte. Hier wird auf die Gefahr der Fetischisierung im Zusammenhang mit utopisch untermalten wissenschaftlich‐technischen Großprojekten und der Phantasie ‚Leben zu machen‘ hingewiesen, und es werden entsprechende Motive und Narrative der,longue‐durée‘ aufgegriffen, z.B. künstliche Menschen, menschliche Hybris und das Außer‐Kontrolle‐Geraten wissenschaftlich‐technischer Großprojekte. Unter der Fragestellung, wie kritische Wissenschaftsreflexion im Medium von Literatur erfolgen kann und was der spezifische Beitrag aus der Wissenschaftsgeschichte wäre, behandelt dieser Essay neben Werken von Michael Crichton (vor allem Next und Lost World, 1997) auch die satirischen Novellen Die verhängnisvollen Eier (1924/1925) und Hundeherz (1926/1968) von Mikhail Bulgakov, da bereits dort die (mögliche) künstliche Hervorbringung von Lebewesen unter der Bedingung eines (versuchten) direkten Zugriffs auf deren Reproduktionsmechanismen fokussiert wurde. Wissenschaftskritik als Gesellschaftskritik zeigt sich hier als Reflexion auf die Grenzen zwischen Wissenschaft und Gesellschaft und auf die Verantwortung der entlang dieser Grenzen agierenden Menschen, aber auch auf strukturelle Gewalt und deren Auswirkungen auf die Verhältnisse zwischen Menschen und Naturdingen sowie unter Menschen.Summary: What's Next? Michael Crichton's and Mikhail Bulgakov's Criticism of Fetishism in the Life Sciences. This paper was first inspired by Michael Crichton's last thriller, Next (2006), which staged hopes and fears triggered by the completion of the Human Genome Project and by the perfection of Polymerase chain reaction techniques, enabling the replication of DNA on a large scale. These developments nourished fantasies about the artificial (re)construction of living beings from DNA. Crichton had already warned of the fetishization of artificially produced living beings in Jurassic Park and in the novels on which the film was based inventing a futuristic scenario where this was happening on a large scale. Here, the topics of hubris and hybrids were center stage. In Next, the fetishization of life is an effect of the growing encroachment of economic actors upon the life sciences. This paper compares Crichton's criticism of techno‐scientific fetishism with Mikhail Bulgakov's critical account of human tinkering with the reproductive organs of humans and non‐humans in his two satirical novels The Fateful Eggs and Dog's Heart. The works of both authors link criticism of science with criticism of society. They focus the borders between science and society and analyze the responsibilities of humans who are acting along those borders. The thrillers and satirical novels illustrate the – often violent – power relations between humans and nature and also among humans. Comparing two authors who wrote nearly a century apart from each other and focussing different social systems will help compare longue‐durée and more specific forms of techno‐scientific fetishism. (shrink)

The nuclear engineer emerged as a new form of recognised technical professional between 1940 and the early 1960s as nuclear fission, the chain reaction and their applications were explored. The institutionalization of nuclear engineering channelled into new national laboratories and corporate design offices during the decade after the war, and hurried into academic venues thereafter proved unusually dependent on government definition and support. This paper contrasts the distinct histories of the new discipline in the USA and UK (and, more (...) briefly, Canada). In the segregated and influential environments of institutional laboratories and factories, historical actors such as physicist Walter Zinn in the USA and industrial chemist Christopher Hinton in the UK proved influential in shaping the roles and perceptions of nuclear specialists. More broadly, I argue that the State-managed implantation of the new subject within further and higher education curricula was shaped strongly by distinct political and economic contexts in which secrecy, postwar prestige and differing industrial cultures were decisive factors. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:“We Need to Cut the Neck!”Confronting Psychological and Moral Distress during Emergency Cricothyrotomy1Stephanie CooperEnoughYou didn’t die in the ER, but rather, began your inexorable demise. The last, first, and only words I ever heard you utter was the weak mewl “tight, tight” as the blood pressure cuff constricted your left arm. You were 98–years–old, bed–bound, at the end. Your world was already partitioning itself from us, your brain tunneling (...) down the uneven corridors of consciousness. A concretion of otoliths muffled your hearing, and fatigue burdened your ancient heart.Your name–band encircled your skinny ankle like a bird. Deformed by arthritis, you were caged within yourself, imprisoned by senescence. You could not declare yourself to us. Words disintegrated into moans and your grimace became animal.When you came back from x–ray—hypotensive with multiple neck fractures confirmed—you could speak no more. Your pulse slowed, your blood pressure plummeted. I jammed a gloved finger against your femoral pulse, faint and tired. [End Page E5]“What’s her DNR status?” I gravely asked your nurse.The DNR paperwork for once had arrived with the patient. “No CPR” she said with relief. But then the paperwork went on, forcing me—the waitress of tragedy—to serve up the hash of an impossible menu.As health care providers, we are all often tasked with performing contradictory actions: the pain of IV insertion followed by the morphine push, drilling deeper into broken bone in order to plate it, the inadvertent cracking of ribs during chest compressions. We sometimes must perform violent action in the hope of sustaining and resurrecting life. We are asked to perform the impossible, the contradictory, the painful. And sometimes the actions we must take catalyze an inexorable chain reaction of actions, which can end in death–prolonging and painful interventions that we did not intend.Although our culture may imagine that one can choose one’s meal at the end–of–life fast–food franchise of death, such is not the case. You can’t suddenly decide you’re a vegetarian. You can’t order the cheeseburger without the cheese—and we all are getting the burger, in the end. Ordering the heart–squeezing drugs without the CPR to circulate them, or the antibiotics without the fluid to counter dehydration, is like ordering the burger without the bun. Sometimes the possible choices are not necessarily realistic choices. You get served what you get served, and perhaps we should question the assumption that we have the ability to choose at all.Your DNR form proclaimed no CPR but then said that antibiotics and intubation were okay—the cheeseburger without the cheese. An unfortunate choice for you, me, and the rest of us, as your death menu led to a very unhappy meal.You were comatose. I stuck a tongue blade deep into your desiccated throat. You did not gag. This means I should have intubated you, but morally, I couldn’t. To what end? You were 98 years old, broken, moribund. If you hadn’t suffered multiple neck fractures, or if you were a vibrant elder who had just walked off Mt. Rainier, maybe the story would have been different. But you? I doubted that you truly had a chance of ever feeling joy again. You were somebody’s wife, somebody’s mother. I knew this step would lead to the domino of unstoppable steps. I refused to flog your corpse.I called your daughter Kay on her cell phone, told her that you were in critical condition and that she should come to the ER immediately. But how to begin to tell a daughter her mother is dying, let alone over a cell phone? Gentle but surreal and impersonal, my voice tried to tell your daughter that the interventions you needed would likely kill you. I have seen enough human suffering to know. To me, the choices were clear: death by nature’s irrefutable course, versus a more painful, protracted, and violent death by what we’d do to you.Kay arrived in a wheelchair and scooted up to your bedside. Like all daughters, she wasn’t ready for you... (shrink)

I have been involved with the current interest in de‐extinction since early 2012, nearly its beginning. I have given a lot of thought to the potential risks and benefits of de‐extinction. But only recently, after deep immersion in discussions around CRISPR‐Cas9, the hottest new tool in bioscience since polymerase chain reaction, have I thought about a more fundamental question: how, if at all, is de‐extinction special? Are “revived species” just another kind of genetically modified organism, raising essentially the same (...) general concerns? I answer, for the most part, yes. De‐extinction is not (very) special. New biotechnologies are giving humans even more power to change the biosphere but more directly, more quickly, and more utterly than ever before. De‐extinction is just one possible, and probably small, use of those technologies. Our attention, for the most part, should be on the bigger issues of regulating this power, rather than focusing specifically on their application to de‐extinction. (shrink)

The assumption that all life on Earth today shares the same basic molecular architecture and biochemistry is part of the paradigm of modern biology. This paper argues that there is little theoretical or empirical support for this widely held assumption. Scientists know that life could have been at least modestly different at the molecular level and it is clear that alternative molecular building blocks for life were available on the early Earth. If the emergence of life is, like other natural (...) phenomena, highly probable given the right chemical and physical conditions then it seems likely that the early Earth hosted multiple origins of life, some of which produced chemical variations on life as we know it. While these points are often conceded, it is nevertheless maintained that any primitive alternatives to familiar life would have been eliminated long ago, either amalgamated into a single form of life through lateral gene transfer (LGT) or alternatively out-competed by our putatively more evolutionarily robust form of life. Besides, the argument continues, if such life forms still existed, we surely would have encountered telling signs of them by now. These arguments do not hold up well under close scrutiny. They reflect a host of assumptions that are grounded in our experience with large multicellular organisms and, most importantly, do not apply to microbial forms of life, which cannot be easily studied without the aid of sophisticated technologies. Significantly, the most powerful molecular biology techniques available—polymerase chain reaction (PCR) amplification of rRNA genes augmented by metagenomic analysis—could not detect such microbes if they existed. Given the profound philosophical and scientific importance that such a discovery would represent, a dedicated search for ‘shadow microbes’ (heretofore unrecognized ‘alien’ forms of terran microbial life) seems in order. The best place to start such a search is with puzzling (anomalous) phenomena, such as desert varnish, that resist classification as ‘biological’ or ‘nonbiological’. Ó 2007 Elsevier Ltd.. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:February 19, 2011 (11:48 am) E:\CPBR\RUSSJOUR\TYPE3002\russell 30,2 040 red.wpd 168 Reviews A CONSCIENCE IN ACTION Chad Trainer 1006 Davids Run Phoenixville, pa 19460, usa [email protected] Reiner Braun, Robert Hinde, David Krieger, Harold Kroto, and Sally Milne, eds. Joseph Rotblat: Visionary for Peace. Weinheim, Germany: Wiley-vch Verlag GmbH & Co. KGaA, 2007. Pp. xiv, 355. isbn 978-3-527-40690-6 (hb). us$60. People who detest barbarism start to act in a barbaric way. (...) This is the insanity of war. (zJoseph Rotblat, p. 168) Bertrand Russell’s famous 1954 bbc broadcast “Man’s Peril” concerned humanity ’s fate in an era of nuclear weaponry. Soon after this event, it occurred to Russell that a further course of action would be to persuade prominent scientists from both sides of the Iron Curtain to sign a statement emphasizing the importance of joint action in addressing the spectre of a world in which there was availability of and even will to use nuclear armaments. He sent a draft of his petition to Albert Einstein for approval. Shortly thereafter, on a Xight from Rome to Paris, Russell heard the pilot’s announcement that Einstein had February 19, 2011 (11:48 am) E:\CPBR\RUSSJOUR\TYPE3002\russell 30,2 040 red.wpd Reviews 169 1 Rotblat was the recipient of the 1983 Bertrand Russell Society Award (McCoy, Visionary for Peace, p. 205, and Rotblat’s c.v., ibid., p. 346). died. Upon arriving at his Paris hotel, Russell found a letter from Einstein agreeing to sign Russell’s statement. In his autobiography, Russell reports: “This was one of the last acts of his [Einstein’s] public life.” Joseph Rotblat (1908–2005)1 met Russell in 1954 at a dinner-discussion given by the bbc on the results of the Bikini test and the future of nuclear weapons. Rotblat went on to become an adviser to Russell on the details of nuclear weapon science and was subsequently recruited by the latter to sign the same document Einstein had. Rotblat chaired the press conference on 9 July 1955 at Caxton Hall in London, presenting the world with what became known as the Russell– Einstein Manifesto. Rotblat was the Manifesto’s youngest and, until his death in 2005, the last surviving signatory. Although Rotblat was not a Nobel Laureate, Russell predicted, correctly, that he would eventually become one. In reference to Rotblat and his activities, Russell remarked: He can have few rivals in the courage and integrity and complete self-abnegation with which he has given up his own career (in which, however, he still remains eminent) to devote himself to combatting the nuclear peril as well as other, allied evils. If ever these evils are eradicated and international aTairs are straightened out, his name should stand very high indeed among the heroes. (Auto. 3: 77–8) Joseph Rotblat: Visionary for Peace is a compilation of tributes to the late Joseph Rotblat published by Wiley-vch. It features no less than 45 contributors. The volume is a celebration of one of the truly great activists for nuclear disarmament. It also features as an 84-page appendix eight of his most historic writings. There is also a new photograph of Russell (p. 89). As justly famous as Rotblat is for his eTorts to prevent nuclear war, though, his distinction in this arena tends to eclipse his other impressive achievements, most notably those in nuclear and medical physics. Joseph Rotblat: Visionary for Peace is valuable for the attention it draws to both the more and less famous aspects of his legacy. In the present reviewer’s opinion, the book’s reminiscences have some unnecessary overlap and the editors could perhaps have more strongly encouraged each contributor to further develop instead the distinctivez things they had to say about Rotblat. Somewhat less forgivable, considering the rich details of Rotblat’s life, is the book’s lack of an index. A Polish Jew, Rotblat earned his doctorate in physics from the University of Warsaw. Among the Wrst to conclude in the late 1930s that the huge energy released by Wssion together with neutron multiplication led to the possibility of a chain reaction, Rotblat realized... (shrink)

The assumption that all life on Earth today shares the same basic molecular architecture and biochemistry is part of the paradigm of modern biology. This paper argues that there is little theoretical or empirical support for this widely held assumption. Scientists know that life could have been at least modestly different at the molecular level and it is clear that alternative molecular building blocks for life were available on the early Earth. If the emergence of life is, like other natural (...) phenomena, highly probable given the right chemical and physical conditions then it seems likely that the early Earth hosted multiple origins of life, some of which produced chemical variations on life as we know it. While these points are often conceded, it is nevertheless maintained that any primitive alternatives to familiar life would have been eliminated long ago, either amalgamated into a single form of life through lateral gene transfer or alternatively out-competed by our putatively more evolutionarily robust form of life. Besides, the argument continues, if such life forms still existed, we surely would have encountered telling signs of them by now. These arguments do not hold up well under close scrutiny. They reflect a host of assumptions that are grounded in our experience with large multicellular organisms and, most importantly, do not apply to microbial forms of life, which cannot be easily studied without the aid of sophisticated technologies. Significantly, the most powerful molecular biology techniques available—polymerase chain reaction amplification of rRNA genes augmented by metagenomic analysis—could not detect such microbes if they existed. Given the profound philosophical and scientific importance that such a discovery would represent, a dedicated search for ‘shadow microbes’ seems in order. The best place to start such a search is with puzzling phenomena, such as desert varnish, that resist classification as ‘biological’ or ‘nonbiological’. (shrink)

In environmental ethics a debate has arisen over the extent to which the individual should make changes in personal lifestyle in a long-term program of ameliorating environmental degradation, as opposed to directing energies toward public-policy change. In opposition are the facts that an individual’s contribution to environmental degradation can only have a negligible effect. Public policy offers the only real hope for such massive coordinated effort, and environmental degradation is only one of many global problems to which ethi­cally oriented people (...) must focus their attentions and energies. So far, the pro-personal responsibility side has urged that personal lifestyle changes are necessary for moral coher­ence, thus in turn for integrity of character, and lifestyle changes can affect others in a kind of chain reaction because humans are socially submerged beings. The stalemate here can only stymies the needed coordinated effort toward ameliorating environmental degradation. Further, moral concerns need to be brought into this issue; namely, the ramifications of pursuing a policy-only approach, emphasizing policy as the sole (or even primary) means of ameliorating environmental degradation, implicitly undercuts the role of individual agents in morality in general, in terms of (1) individual responsibility, (2) autonomy, and (3) creativity in solving problems. All these problems not only bear on the program to reverse environmental degradation, but undermine other widely held moral values. Emphasizing personal lifestyle responsibility is not only the most moral alternative but is also the most assured way to affect long-term changes and the better way to make policy changes credible and sufficiently substantive for change. (shrink)

Recognizing the profound need for greater patient and provider familiarity with personalized genomic medicine, many university instructors are including personalized genotyping as part of their curricula. During seminars and lectures students run polymerase chain reactions on their own DNA or evaluate their experiences using direct-to-consumer genetic testing services subsidized by the university. By testing for genes that may influence behavioral or health-related traits, however, such as alcohol tolerance and cancer susceptibility, certain universities have stirred debate on the ethical (...) concerns raised by educational genotyping. Considering the potential for psychosocial harm and medically relevant outcomes, how far should university-facilitated DNA testing be permitted to go? The analysis here distinguishes among these learning initiatives and critiques their approaches to the ethical concerns raised by educational genotyping. (shrink)

Just like atomic physics seventy years ago, when it was realized that chain reaction could lead to medical applications as well as to the creation of atomic weapons, the life sciences have entered a grey zone. “Advances in biotechnology […]” a 2003 CIA document stated, “have the potential to create a much more dangerous biological warfare threat […] Engineered biological agents could be much worse than any disease known to man”. As sociologists of science have noted, contemporary life sciences (...) have dual use potential as they can be used to foster beneficial applications, for instance in health care, or generate harm, either intentionally or not, and possibly on an unprecedented.. (shrink)

The authors of the article are trying to identify the signs of a crisis of our time as a consequence of the refusal from the philosophical justification of the goals and objectives of scientific pedagogy, which as a chain reaction entail ignoring the results of sciences related to pedagogy: neurobiology and psychology. The reproductive approach in education selectively takes into account the results of the empirical sciences, as they serve to justify it. The result is a shift in emphasis: (...) being driven by the hypothetical imperatives of competitiveness in the labor market, teachers and other adults feel the need for the achievements of the pupils, for their effectiveness. As a consequence, the child's psyche does not develop properly which manifests itself in the inability to see the subjects of interaction in the vis-a-vis, in an effort to objectify what is not subject to objectification - a person. The authors of the article see the solution to the problem in the appeal in the philosophical and pedagogical system of I. Kant, that may be reconstructed from his works. The authors of the article conclude that I. Kant may rightfully be considered the founder of a productive approach to education. (shrink)

In previous studies, as an important object of inheritance and promotion of Chinese culture in Chinese colleges and universities, the psychological change mechanism of college students in the process of receiving cultural identity education has not attracted widespread attention. This study focuses on ideological and political education in colleges and universities, and innovatively believes that in order to improve college students’ identification with Chinese culture, and make them consciously “internalize in mind and externalize in practice,” it is necessary to explore (...) their psychological structure and mechanism of action in the process of accepting identity education and take measures to actively intervene. The study employs the method of questionnaire investigation, acquiring 1,119 effective samples from 30 universities in Fujian province. By establishing the theoretical framework of “cognitive identity—emotional identity—ideological identity—behavioral identity,” analyzing and examining the data, it is found out that: cognitive identity affecting behavioral identity positively in a noticeable way; by raising individual emotional identity, cognitive identity strengthening university students’ behavioral identity; cognitive identity inspiring behavioral identity with benefits of ideological identity; it being verified that there exists an intermediary chain reaction between emotional identity, ideological identity, cognitive identity, and behavioral identity. As a result, the followings are proposed: further integrating the worthy Chinese traditional culture into university curriculum and developing students’ cognitive education of traditional culture; exploring the aesthetic dimension of worthy Chinese traditional culture and deepening the students’ emotional identity of traditional culture; demonstrating the essence of the worthy Chinese traditional culture and advancing the students’ ideological identity of traditional culture; and intensifying the practice of the worthy Chinese traditional culture and motivating the students’ behavioral identity of traditional culture. (shrink)

The Earth agglomerates and heats. Convection cells within the planetary interior expedite the cooling process. Volcanoes evolve steam, carbon dioxide, sulfur dioxide and pyrophosphate. An acidulous Hadean ocean condenses from the carbon dioxide atmosphere. Dusts and stratospheric sulfurous smogs absorb a proportion of the Sun’s rays. The cooled ocean leaks into the stressed crust and also convects. High temperature acid springs, coupled to magmatic plumes and spreading centers, emit iron, manganese, zinc, cobalt and nickel ions to the ocean. Away from (...) the spreading centers cooler alkaline spring waters emanate from the ocean floor. These bear hydrogen, formate, ammonia, hydrosulfide and minor methane thiol. The thermal potential begins to be dissipated but the chemical potential is dammed. The exhaling alkaline solutions are frustrated in their further attempt to mix thoroughly with their oceanic source by the spontaneous precipitation of biomorphic barriers of colloidal iron compounds and other minerals. It is here we surmise that organic molecules are synthesized, filtered, concentrated and adsorbed, while acetate and methane—separate products of the precursor to the reductive acetyl-coenzyme-A pathway—are exhaled as waste. Reactions in mineral compartments produce acetate, amino acids, and the components of nucleosides. Short peptides, condensed from the simple amino acids, sequester ‘ready-made’ iron sulfide clusters to form protoferredoxins, and also bind phosphates. Nucleotides are assembled from amino acids, simple phosphates carbon dioxide and ribose phosphate upon nanocrystalline mineral surfaces. The side chains of particular amino acids register to fitting nucleotide triplet clefts. Keyed in, the amino acids are polymerized, through acid–base catalysis, to alpha chains. Peptides, the tenuous outer-most filaments of the nanocrysts, continually peel away from bound RNA. The polymers are concentrated at cooler regions of the mineral compartments through thermophoresis. RNA is reproduced through a convective polymerase chain reaction operating between 40 and 100°C. The coded peptides produce true ferredoxins, the ubiquitous proteins with the longest evolutionary pedigree. They take over the role of catalyst and electron transfer agent from the iron sulfides. Other iron–nickel sulfide clusters, sequestered now by cysteine residues as CO-dehydrogenase and acetyl-coenzyme-A synthase, promote further chemosynthesis and support the hatchery—the electrochemical reactor—from which they sprang. Reactions and interactions fall into step as further pathways are negotiated. This hydrothermal circuitry offers a continuous supply of material and chemical energy, as well as electricity and proticity at a potential appropriate for the onset of life in the dark, a rapidly emerging kinetic structure born to persist, evolve and generate entropy while the sun shines. (shrink)

In this chapter, typical examples of methodological individualism explanation are borrowed from Raymond Boudon’s writings. They respectively aim at answering the following questions:Why did Athens’ allies defect in the Peloponnesian War?When does social organization aim at eliminating unintended effects?Why does the rule of unanimity often prevail in traditional village societies?Why do members of an unorganized group tend to defect?Why are collective powers often governed by the iron law of oligarchy?Why did capitalist agriculture develop much more slowly in France than in (...) England in the eighteenth century?Why has the immoral character of interest lending disappeared in modern societies?Why is there no socialism in the United States?Why do economic booms seem to be associated with higher suicide rates?Why does the diffusion of an innovation follow a chain reaction process in situations where interpersonal influence is greater?Why were Mithra cult and Freemasonry, respectively, successful in Ancient Rome and modern Prussia?Why were the peasants in ancient Rome hostile to monotheism?Why did the French intellectuals of the late eighteenth century worship Reason?Why did Indian peasants not adopt the birth control measures advocated by the Indian administration?Why do conflicts between employees in a Taylorized firm tend to be more violent? (shrink)

The nuclear engineer emerged as a new form of recognised technical professional between 1940 and the early 1960s as nuclear fission, the chain reaction and their applications were explored. The institutionalization of nuclear engineering—channelled into new national laboratories and corporate design offices during the decade after the war, and hurried into academic venues thereafter—proved unusually dependent on government definition and support. This paper contrasts the distinct histories of the new discipline in the USA and UK (and, more briefly, Canada). (...) In the segregated and influential environments of institutional laboratories and factories, historical actors such as physicist Walter Zinn in the USA and industrial chemist Christopher Hinton in the UK proved influential in shaping the roles and perceptions of nuclear specialists. More broadly, I argue that the State-managed implantation of the new subject within further and higher education curricula was shaped strongly by distinct political and economic contexts in which secrecy, postwar prestige and differing industrial cultures were decisive factors. (shrink)

A variety of herbicides act by inhibiting the branched chain amino‐acid biosynthetic enzyme, acetolactate synthase (EC 4.1.3.18). The initial consequences of this event are 2‐ketoacid accumulation and amino‐acid starvation. Recent studies demonstrate that 2‐ketoacid imbalances play a significant role in the action of these herbicides; such imbalances may also be important in certain inborn errors of human metabolism.