Alternative splicing is a well‐characterized mechanism by which multiple transcripts are generated from a single mRNA precursor. By allowing production of several protein isoforms from one pre‐mRNA, alternative splicing contributes to proteomic diversity. But what do we know about the origin of this mechanism? Do the same evolutionary forces apply to alternatively and constitutively splice exons? Do similar forces act on all types of alternative splicing? Are the products generated by alternative splicing functional? Why is “improper” recognition of exons and (...) introns allowed by the splicing machinery? In this review, we summarize the current knowledge regarding these issues from an evolutionary perspective. BioEssays 30:38–47, 2008. © 2007 Wiley Periodicals, Inc. (shrink)

This paper analyzes and evaluates quine's influential thesis that epistemology should become a chapter of empirical psychology. quine's main point, it is argued, is that normativity must be banished from epistemology and, more generally, philosophy. i claim that without a normative concept of justification, we lose the very concept of knowledge, and that belief ascription itself becomes impossible without a normative concept of rationality. further, the supervenience of concepts of epistemic appraisal shows that normative epistemology is indeed possible.

This paper evaluates and criticises the developmental systems conception of evolution and develops instead an extension of the gene's eye conception of evolution. We argue (i) Dawkin's attempt to segregate developmental and evolutionary issues about genes is unsatisfactory. On plausible views of development it is arbitrary to single out genes as the units of selection. (ii) The genotype does not carry information about the phenotype in any way that distinguishes the role of the genes in development from that other factors. (...) (iii) There is no simple and general causal criterion which distinguishes the role of genes in development and evolution. (iv) There is, however, an important sense in which genes but not every other developmental factor represent the phenotype. (v) The idea that genes represent features of the phenotype forces us to recognise that genes are not the only, or almost the only, replicators. Many mechanisms of replication are involved in both development and evolution. (vi) A conception of evolutionary history which recognises both genetic and non-genetic replicators, lineages of replicators and interactors has advantages over both the radical rejection of the replicator/interactor distinction and the conservative restriction of replication to genetic replication. (shrink)

This paper explores the fundamental ideas that have motivated the idea of emergence and the movement of emergentism. The concept of reduction, which lies at the heart of the emergence idea is explicated, and it is shown how the thesis that emergent properties are irreducible gives a unified account of emergence. The paper goes on to discuss two fundamental unresolved issues for emergentism. The first is that of giving a “positive” characterization of emergence; the second is to give a coherent (...) explanation of how “downward” causation, a central component of emergentism, is able to avoid the problem of overdetermination. (shrink)

Somewhat loose arguments that non-reductive physicalist realism is untenable. Anomalous monism makes the mental irrelevant, functionalism is compatible with species-specific reduction, and supervenience is weak or reductive.

In “Normativity and Epistemic Intuitions”, Weinberg, Nichols and Stich famously argue from empirical data that East Asians and Westerners have different intuitions about Gettier -style cases. We attempted to replicate their study about the Car case, but failed to detect a cross - cultural difference. Our study used the same methods and case taken verbatim, but sampled an East Asian population 2.5 times greater than NEI’s 23 participants. We found no evidence supporting the existence of cross - cultural difference about (...) the intuition concerning the Gettier car case. Taken together with the failures of both of the existing replication studies, our results provide strong evidence that the purported cross - cultural difference in Gettier intuitions does not exist. (shrink)

Terraformer les planètes lointaines pour les rendre aptes à porter des vies humaines nourrit sans doute des imaginations littéraires, mais ce que nous appelons « vie » reste pour le moment étroitement attaché à notre planète Terre.

The ontological dependence of one domain on another is compatible with the explanatory autonomy of the less basic domain. That autonomy results from the fact that the relationship between two domains can be very complex. In this paper I distinguish two different types of complexity, two ways the relationship between domains can fail to be transparent, both of which are relevant to evolutionary biology. Sometimes high level explanations preserve a certain type of causal or counterfactual information which would be lost (...) at the lower level; I argue that this is central to the proper understanding of the adaptationist program. Sometimes high level kinds are multiply realised by lower level kinds: I argue that this is central to the understanding of macroevolution. (shrink)

We study Kim-independence over arbitrary sets. Assuming that forking satisfies existence, we establish Kim's lemma for Kim-dividing over arbitrary sets in an NSOP1 theory. We deduce symmetry of Kim-independence and the independence theorem for Lascar strong types.

Developing and motivating the notion of supervenience. Investigating the relationship to reducibility and definability (equivalence, under certain conditions), and to microphysical determination.

THIS PAPER CORRECTS AN ERROR IN MY EARLIER PAPER, "CONCEPTS OF SUPERVENIENCE" ("PHILOSOPHY AND PHENOMENOLOGICAL RESEARCH", VOLUME 45, 1984), AND PRESENTS FURTHER MATERIAL ON SUPERVENIENCE. THE ERROR IS THE CLAIM THAT "GLOBAL" SUPERVENIENCE ENTAILS "STRONG" SUPERVENIENCE. HOWEVER, IT IS ARGUED THAT THIS FAILURE OF ENTAILMENT ONLY GOES TO SHOW THE INADEQUACY OF GLOBAL SUPERVENIENCE AS AN EXPLICATION OF "DEPENDENCY" OR "DETERMINATION" RELATION, AND, IN PARTICULAR, THAT MATERIALISM FORMULATED IN TERMS OF GLOBAL SUPERVENIENCE APPEARS TOO WEAK. (IT IS POINTED OUT, AMONG (...) OTHER THINGS, THAT GLOBAL SUPERVENIENCE DOES NOT ENTAIL "WEAK" SUPERVENIENCE). A STRONGER FORM OF GLOBAL SUPERVENIENCE, BASED ON "SIMILARITY" RATHER THAN "INDISCERNIBILITY" BETWEEN WORLDS, IS FORMULATED AND BRIEFLY DISCUSSED. (shrink)

Jaegwon Kim; XIV*—Does the Problem of Mental Causation Generalize?, Proceedings of the Aristotelian Society, Volume 97, Issue 1, 1 June 1997, Pages 281–298, htt.

A common picture of evolution by natural selection sees it as a process through which organisms change so that they become better adapted to their environment. However, agents do not merely respond to the challenges their environments pose. They modify their environments, filtering and transforming the action of the environment on their bodies A beaver, in making a dam, engineers a stream, increasing both the size of its safe refuge and reducing its seasonal variability. Beavers, like many other animals, are (...) ecological engineers. They act to modify the physical challenges posed by their environment. Nests, burrows and other shelters reduce the impacts of adverse weather and of other agents. Animal also modify their exposure to biological risks. Hygienic behaviour reduces the impact of disease. Intensive grooming; moving to new roosts; using a. (shrink)

Hempel and Oppenheim have stated in Part III of their paper “Studies in the Logic of Explanation” [2] a set of conditions for deductive explanation. However, their analysis has come under damaging systematic criticisms in a recent paper by Eberle, Kaplan and Montague [1], The principal aim of the present paper is to review the Hempel-Oppenheim analysis and propose a strengthened version of it that avoids the recent criticisms.

Kim examines the fundamental tenets of Immanuel Kant’s theory of morality structural-methodological point of view to highlight the activities of reason vis-à-vis the blind forces of brute nature. The study provides new perspective on Kant's thought to benefit studies of epistemology, modern philosophy, moral theory and philosophy, and ethics.

Two concepts of supervenience, "strong supervenience" and "weak supervenience," are characterized and contrasted, And their major properties established. Supervenience as commonly characterized by philosophers is shown to correspond to weak supervenience, Whereas the intended concept is often the stronger relation. Strong supervenience is applied to explicate the notion of "supervenient causation," and it is argued that macro-Causal relations can be understood as cases of supervenient causation, And that causal relations involving psychological events, Too, Can be so understood.

This paper surveys recent philosophy of biology. It aims to introduce outsiders to the field to the recent literature (which is reviewed in the footnotes) and the main recent debates. I concentrate on three of these: recent critiques of the replicator/vehicle distinction and its application to the idea of the gene as the unit of section; the recent defences of group selection and the idea that standard alternatives to group selection are in fact no more than a disguised form of (...) group selection; and recent ideas on the role of selection in evolution, especially the role of selection in structuring the large-scale history of life. The paper connects philosophy of biology to some more general problems in the philosophy of science, and concludes with a few suggestions about unfinished business. (shrink)

Firstly, in this paper, we prove that the equivalence of simplicity and the symmetry of forking. Secondly, we attempt to recover definability part of stability theory to simplicity theory. In particular, using elimination of hyperimaginaries we prove that for any supersimple T, canonical base of an amalgamation class P is the union of names of ψ-definitions of P, ψ ranging over stationary L-formulas in P. Also, we prove that the same is true with stable formulas for an 1-based theory having (...) elimination of hyperimaginaries. For such a theory, the stable forking property holds, too. (shrink)

Let T be a countable, small simple theory. In this paper, we prove that for such T, the notion of Lascar strong type coincides with the notion of strong type, over an arbitrary set.

Jaegwon Kim; Supervenient Properties and Micro-Based Properties: A reply to Noordhof, Proceedings of the Aristotelian Society, Volume 99, Issue 1, 1 June 1999.

In men and women sexual arousal culminates in orgasm, with female orgasm solely from sexual intercourse often regarded as a unique feature of human sexuality. However, orgasm from sexual intercourse occurs more reliably in men than in women, likely reflecting the different types of physical stimulation men and women require for orgasm. In men, orgasms are under strong selective pressure as orgasms are coupled with ejaculation and thus contribute to male reproductive success. By contrast, women's orgasms in intercourse are highly (...) variable and are under little selective pressure as they are not a reproductive necessity. The proximal mechanisms producing variability in women's orgasms are little understood. In 1924 Marie Bonaparte proposed that a shorter distance between a woman's clitoris and her urethral meatus (CUMD) increased her likelihood of experiencing orgasm in intercourse. She based this on her published data that were never statistically analyzed. In 1940 Landis and colleagues published similar data suggesting the same relationship, but these data too were never fully analyzed. We analyzed raw data from these two studies and found that both demonstrate a strong inverse relationship between CUMD and orgasm during intercourse. Unresolved is whether this increased likelihood of orgasm with shorter CUMD reflects increased penile–clitoral contact during sexual intercourse or increased penile stimulation of internal aspects of the clitoris. CUMD likely reflects prenatal androgen exposure, with higher androgen levels producing larger distances. Thus these results suggest that women exposed to lower levels of prenatal androgens are more likely to experience orgasm during sexual intercourse. . (shrink)

In this paper I argue that Confucius' view of learning in the Analects entails critical thinking. Although he neither specified the logical rules of good reasoning nor theorised about the structure of argument, Confucius advocated and emphasised the importance of critical thinking. For Confucius reflective thinking of two sorts is essential to learning: (1) reflection on the materials of knowledge, in order to synthesise and systemise the raw materials into a whole, and to integrate them into oneself as wisdom; (2) (...) reflection on oneself, (a) in order to ensure that such synthesis, systemisation, and integration proceed in an open-minded, fair and autonomous way, and (b) in order to integrate knowledge with the self, that is, to internalise it until it becomes oneself. (shrink)

The aim of this paper is to shed new light on the logical roots of arithmetic by presenting a logical framework that takes seriously ordinary locutions like ‘at least n Fs’, ‘n more Fs than Gs’ and ‘n times as many Fs as Gs’, instead of paraphrasing them away in terms of expressions of the form ‘the number of Fs’. It will be shown that the basic concepts of arithmetic can be intuitively defined in the language of ALA, and the (...) Dedekind–Peano axioms can be derived from those definitions by logical means alone. It will also be shown that some fundamental facts about cardinal numbers expressed using singular terms of the form ‘the number of Fs’, including Hume’s Principle, can be derived solely from definitions. (shrink)