In the article “Fifty Years of U.S. Mass Incarceration and What It Means for Bioethics,” Sean Valles provides an important reminder of the consequences of mass incarceration in the United States and identifies potential roles for bioethicists in addressing this system. My limited view—that of a physician who conducts court‐ordered investigations and monitoring of health services behind bars—is that the ongoing failure of most academic and professional organizations to be more effective in this much‐ignored area stems from the lack of (...) leaders and staff who have been directly impacted by mass incarceration. As conditions behind bars worsen, and a new war on drugs recoils the spring of mass incarceration, there is a pressing need to train, recruit, and promote people who know the realities of the criminal (and immigration) justice system and its impact on health and well‐being. This step can bring a more powerful engagement of bioethics regarding housing, employment, and health care and policing, as well as the numerous and harmful elements of jails, prisons, and detention settings. I provide examples of partners I learn from in this arena, as well as some discrete and technical areas for possible investigation. (shrink)

Every year, hundreds of patients in England die whilst waiting for a kidney transplant, and this is evidence that the current system of altruistic-based donation is not sufficient to address the shortage of kidneys available for transplant. To address this problem, we propose a monopsony system whereby kidney donors can opt-in to receive financial compensation, whilst still preserving the right of individuals to donate without receiving any compensation. A monopsony system describes a market structure where there is only one ‘buyer’—in (...) this case the National Health Service. By doing so, several hundred lives could be saved each year in England, wait times for a kidney transplant could be significantly reduced, and it would lessen the burden on dialysis services. Furthermore, compensation would help alleviate the common disincentives to living kidney donation, such as its potential associated health and psychological costs, and it would also help to increase awareness of living kidney donation. The proposed system would also result in significant cost savings that could then be redirected towards preventing kidney disease and reducing health disparities. While concerns about exploitation, coercion, and the ‘crowding out’ of altruistic donors exist, we believe that careful implementation can mitigate these issues. Therefore, we recommend piloting financial compensation for living kidney donors at a transplant centre in England. (shrink)

Predictive processing is often presented as a unifying framework for perception, action, and cognition, being able to explain most mental phenomena : with regard to perception, the brain harbours a generative model issuing top-down expectations that are matched against bottom-up sensory feedback. Mismatches lead to error messages and model updates until the brain is 'getting it right'. The core notion of prediction error minimization commits the framework to a specification of accuracy conditions. We therefore turn to issues related to the (...) determination of satisfaction conditions discussed in the philosophy of perception. In particular, we rely on work by Recanati who shows that the accuracy conditions of perceptual content are partly determined by the intentional mode and the perceiver. It is important to notice that the self can enter the specification of accuracy conditions in two ways, namely as subject or as object. Even if we do not perceive ourselves explicitly as an object, we always implicitly represent ourselves as subject. We discuss whether and how these two ways of self-representation can be respected in the predictive processing framework. (shrink)

In this paper, I argue for an embodied, embedded approach to predictive processing and thus align the framework with situated cognition. The recent popularity of theories conceiving of the brain as a predictive organ has given rise to two broad camps in the literature that I call free energy enactivism and cognitivist predictive processing. The two approaches vary in scope and methodology. The scope of cognitivist predictive processing is narrow and restricts cognition to brain processes and structures; it does not (...) consider the body-beyond-brain and the environment as constituents of cognitive processes. Free energy enactivism, on the other hand, includes all self-organizing systems that minimize free energy and thus does not offer any unique explanations for more complex cognitive phenomena that are unique to human cognition. Furthermore, because of its strong commitment to the mind-life continuity thesis, it does not provide an explanation of what distinguishes more sophisticated cognitive systems from simple systems. The account that I develop in this paper rejects both of these radical extremes. Instead, I propose a compromise that highlights the necessary components of predictive processing by making use of a mechanistic methodology of explanation. The starting point of the argument in this paper is that despite the interchangeable use of the terms, prediction error minimization and the free energy principle are not identical. But this distinction does not need to disrupt the status quo of the literature if we consider an alternative approach: Embodied, Embedded Predictive Processing. EEPP accommodates the free energy principle, as argued for by free energy enactivism, but it also allows for mental representations in its explanation of cognition. Furthermore, EEPP explains how prediction error minimization is realized but, unlike cognitivist PP, it allocates a constitutive role to the body in cognition. Despite highlighting concerns regarding cognitivist PP, I do not wish to discredit the role of the neural domain or representations as free energy enactivism does. Neural structures and processes undeniably contribute to the minimization of prediction error but the role of the body is equally important. On my account, prediction error minimization and free energy minimization are deeply dependent on the body of an agent, such that the body-beyond-brain plays a constitutive role in cognitive processing. I suggest that the body plays three constitutive roles in prediction error minimization: The body regulates cognitive activity, ensuring that cognition and action are intricately linked. The body acts as distributor in the sense that it carries some of the cognitive load by fulfilling the function of minimizing prediction error. Finally, the body serves to constrain the information that is processed by an agent. In fulfilling these three roles, the agent and environment enter into a bidirectional relation through influencing and modeling the structure of the other. This connects EEPP to the free energy principle because the whole embodied agent minimizes free energy in virtue of being a model of its econiche. This grants the body a constitutive role as part of the collection of mechanisms that minimize prediction error and free energy. The body can only fulfill its role when embedded in an environment, of which it is a model. In this sense, EEPP offers the most promising alternative to cognitivist predictive processing and free energy enactivism. (shrink)

The notion of ubuntu and communalism is of great importance in anAfrican educational discourse, as well as inAfrican Philosophy of Education and in Africanphilosophical discourse. Ubuntu is aphilosophy that promotes the common good ofsociety and includes humanness as an essentialelement of human growth.

The last few years have seen dramatic progress in the development of HIV pre-exposure prophylaxis (PrEP). These developments have been met by ethical concerns. HIV interventions are often thought to be ethically difficult. In a context which includes disagreements over human rights, controversies over testing policies, and questions about sexual morality and individual responsibility, PrEP has been seen as an ethically complex intervention. We argue that this is mistaken, and that in fact, PrEP does not raise new ethical concerns. Some (...) of the questions posed by PrEP are not specific to HIV prophylaxis, but simply standard public health considerations about resource allocation and striking a balance between individual benefit and public good. We consider sexual disinhibition in the context of private prescriptions, and conclude that only unjustified AIDS-exceptionalism or inappropriate moralism about sex supports thinking that PrEP raises new ethical problems. This negative conclusion is significant in a context where supposed ethical concerns about PrEP have been raised, and in the context of HIV exceptionalism. (shrink)

In this article, a brief survey of some of the ways in which biblical scholars try to make sense of the coronavirus disease 2019 (COVID-19) pandemic is offered. The views of the following scholars are discussed: Walter Brueggemann, Ying Zhang, John Goldingay and Kathleen Scott Goldingay, N.T. Wright, Philemon M. Chamburuka and Ishanesu S. Gusha, and Peter Lampe. This is followed by the reflections of a biblical scholar and a systematic theologian. From the perspective of a biblical scholar, the following (...) issues are raised: the richness of biblical traditions, the influence of social location on the interpretation of the pandemic in the light of the Bible, the importance of the emphasis on lament, the reluctance to interpret the pandemic as a punishment from God, the importance of the interpreter’s view of God and the emphasis on the way in which the ‘new normal’ should be approached. From the perspective of a systematic theologian the following issues are discussed: The nature of doing theology, the role of the symbol of the Divine, performativity of sense-making, the Trinitarian confession, an emerging new self and the importance of an ethic of responsibility. Contribution: The article is a response to the COVID-19 pandemic and emphasises the critical importance of engaging the Christian scripture. The role accorded to hermeneutics and to an explicit interdisciplinary conversation makes a particular contribution to the emerging crisis discourse. (shrink)

In a competitive, globalised world, corporate social responsibility (CSR) is proposed as a strategy to invigorate the competitiveness of small- and medium-sized enterprises (SMEs). The primary objective of this paper is to identify CSR factors that influence the competitiveness of SMEs and to develop a hypothesised model that can be tested on SMEs. Although SMEs in Uganda are increasingly becoming the backbone of the economy, their rate of survival and competitiveness are a cause for concern. The outcomes of CSR activities (...) can help to improve the survival rate of SMEs, and may offer great opportunities for business competitiveness, locally and globally. (shrink)

SMEs are the driving force of economies. However, they face challenges that affect their long-term survival, such as developing ethical business environments. Business ethicsrelated research is underdeveloped in SMEs, thus limiting our understanding of business ethics in SMEs. The purpose of this qualitative study was to investigate how business ethics is conceptualised in SMEs, using the Delphi Technique. In SMEs, business ethics is viewed as doing the right thing, having integrity, being transparent, trustworthy, and behaving responsibly towards internal and external (...) parties. The contribution of this article is that business ethics is perceived as upholding quality, being transparent and trustworthy. (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

This article offers a unified theory of the licensing of Negative and Positive Polarity Items, focusing on the acceptability conditions of PPIs of the some-type, and NPIs of the any-type. It argues that licensing has both a syntactic and a semantic component. On the syntactic side, the acceptability of PIs is checked in constituents; in fact, for any given PI, only some constituents, referred to as `domains', are eligible for the evaluation of that PI. The semantic dimension of licensing consists (...) in the sensitivity of PIs to the monotonicity properties of the syntactic environments they find themselves in. Two pieces of evidence support the semantic dimension of what I call the ‘environment-based’ approach defended here: PIs are subject to flip-flop and certain inferences affect their acceptability by modifying the monotonicity of their environment. A third property, called ‘entanglement’ and so far unnoticed, is described: the acceptability of PIs depends on the acceptability of other PIs in the same syntactic environment. The latter property is exploited to determine what semantic property some is sensitive to: it turns out that, contrary to the consensus among researchers, some is acceptable in the complement of the set of environments in which any is acceptable, and vice versa. (shrink)

This prose translation of the Odyssey is so successful that it has taken its place as one of the few really outstanding versions of Homer's famous epic poem. It is the story of the return of Odysseus from the siege of Troy to his home in Ithaca, and of the vengeance he takes on the suitors of his wife Penelope. Odysseus's account of his adventures since leaving Troy includes his encounter with the enchantress Circe, his visit to the Underworld, (...) and the lure of the Sirens. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more. (shrink)

Deception has been practiced by sellers since the beginning of the marketplace. Research in marketing ethics has established benchmarks and parameters forethical behavior that include honesty, full disclosure, equity, and fairness. Deception in marketing, however, has not received the same level of attention. This paper proposes to treat deception in marketing within the context of criminology. By examining deception in marketing within the context of criminology, additional insight can be gained into identifying its antecendents and the likelihood of its occurrence. (...) To this end, deception in marketing is interpreted under the empathy/harm matrix, Cressey’s fraud triangle, and the transparency/time-lag matrix. These frameworks are then combined into a diagram detailing antecedents affecting the likelihood of marketing agents participating in deceptive marketing actions. A number of propositions are presented. (shrink)