With the advent of the Human Genome Project there have been many claims for the genetic origins of complex human behavior including insanity, criminality, and intelligence. But what does it really mean to call something 'genetic'? This is the fundamental question that Sahotra Sarkar's book addresses. The author analyses the nature of reductionism in classical and molecular genetics. He shows that there are two radically different kinds of reductionist explanation: genetic reduction (as found in classical genetics) and physical reduction (...) (found in molecular genetics). This important book clarifies the meaning of the term 'genetic', shows how molecular studies have affected genetics, and provides the philosophical background necessary to understand the debates over the Human Genome Project. It will be of particular interest to professionals and students in the philosophy of science, the history of science, and the social studies of science, medicine, and technology. (shrink)

The philosophy of science is the branch of philosophy that examines the profound philosophical questions that arise from scientific research and theories. A sub-discipline of philosophy that emerged in the twentieth century, the philosophy of science is largely a product of the British and Austrian schools of thought and traditions. The first in-depth reference in the field that combines scientific knowledge with philosophical inquiry, The Philosophy of Science: An Encyclopedia is a two-volume set that brings together an international team of (...) leading scholars to provide over 130 entries on the essential concepts in the philosophy of science. The areas covered include biology, chemistry, epistemology and metaphysics, physics, psychology and mind, the social sciences, and key figures in the combined studies of science and philosophy. Essays range in length from 3,000 to 7,500 words and represent the most up-to-date philosophical thinking on timeless scientific topics such as determinism, explanation, laws of nature, perception, individuality, time, and economics as well as timely topics like adaptation, conservation biology, quantum logic, consciousness, evolutionary psychology, and game theory. Offering thorough explorations and destined to become the most authoritative presentation of the field available, this Encyclopedia is a unique and groundbreaking guide to this fascinating field. (shrink)

BackgroundStudies on different methods to supplement the traditional informed consent process have generated conflicting results. This study was designed to evaluate whether participants who received group counseling prior to administration of informed consent understood the key components of the study and the consent better than those who received individual counseling, based on the hypothesis that group counseling would foster discussion among potential participants and enhance their understanding of the informed consent.MethodsParents of children participating in a trial of nutritional supplementation were (...) randomized to receive either group counseling or individual counseling prior to administration of the informed consent. To assess the participant's comprehension, a structured questionnaire was administered approximately 48-72 hours afterwards by interviewers who were blinded to the allocation group of the respondents.ResultsA total of 128 parents were recruited and follow up was established with 118 (90.2%) for the study. All respondents were aware of their child's participation in a research study and the details of sample collection. However, their understanding of study purpose, randomization and withdrawal was poor. There was no difference in comprehension of key elements of the informed consent between the intervention and control arm.ConclusionsThe results suggest that the group counseling might not influence the overall comprehension of the informed consent process. Further research is required to devise better ways of improving participants' understanding of randomization in clinical trials.Trial RegistrationClinical Trial Registry - India (CTRI): CTRI/2009/091/000612. (shrink)

Study on religious and social values of people as influenced by the philosophical views of Ramakrishna, 1836-1886 in his time.

The first in-depth reference to the field that combines scientific knowledge with philosophical inquiry, this encyclopedia brings together a team of leading scholars to provide nearly 150 entries on the essential concepts in the philosophy of science. The areas covered include biology, chemistry, epistemology and metaphysics, physics, psychology and mind, the social sciences, and key figures in the combined studies of science and philosophy. (Midwest).

A new direction in philosophy Between 1920 and 1940 logical empiricism reset the direction of philosophy of science and much of the rest of Anglo-American philosophy. It began as a relatively organized movement centered on the Vienna Circle, and like-minded philosophers elsewhere, especially in Berlin. As Europe drifted into the Nazi era, several important figures, especially Carnap and Neurath, also found common ground in their liberal politics and radical social agenda. Together, the logical empiricists set out to reform traditional philosophy (...) with a new set of doctrines more firmly grounded in logic and science. Criticism and decline Because of Nazi persecution, most of the European adherents of logical empiricism moved to the United States in the late 1930s. During the 1940s, many of their most cherished tenets became targets of criticism from outsiders as well as from within their own ranks. Philosophers of science in the late 1950s and 1960s rejected logical empiricism and, starting in the 1970s, presented such alternative programs such as scientific realism with evolutionary epistemology. A resurgence of interest During the early 1980s, philosophers and historians of philosophy began to study logical empiricism as an important movement. Unlike their predecessors in the 1960s-for whom the debate over logical empiricism now seems to have been largely motivated by professional politics-these philosopher no longer have to take positions for or against logical empiricism. The result has been a more balanced view of that movement, its achievements, its failures, and its influence. Hard-to-find core writings now available This collection makes available a selection of the most influential and representative writings of the logical empiricists, important contemporary criticisms of their doctrines, their responses, as well as the recent reappraisals. Introductions to each volume examine the articles in historical context and provide importantbackground information that is vital to a full understanding of the issues discussed. They outline prevalent trends, identifying leading figures and summarize their positions and reasoning, as well as those of opposing thinkers. (shrink)

By now it has become commonplace to note that the early Carnap was strongly influenced by Kant and the neo-Kantianism of his day.1 As early as 1977 Haack noted some striking similarities between the Aufbau and the first Critique; since then, Haack’s observation has been underscored by documenting the explicit role of the neo-Kantians in Carnap’s early education and intellectual development.2 Whether or not Carnap in the Aufbau was at all interested in traditional empiricism, or even strongly influenced by Russell, (...) remains debatable.3 However, a decisive early influence of Kant cannot be persuasively denied. Nevertheless, Kant and the neo-Kantians do not comprise the whole story. An equally important influence on Carnap in Der Raum, though perhaps slightly less so in the Aufbau, was Husserl.4 This paper begins the project of tracing the precise extent and nature of that influence.KeywordsPhysical SpaceFormal SpaceLogical EmpiricismVienna CircleLogical SyntaxThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves. (shrink)

The first in-depth reference in the field that combines scientific knowledge with philosophical inquiry, _The Philosophy of Science: An Encyclopedia_ is a two-volume set that brings together an international team of leading scholars to provide over 130 entries on the essential concepts in the philosophy of science. _The areas covered include:_ biology chemistry epistemology and metaphysics physics psychology and mind the social sciences key figures in the combined studies of science and philosophy. The essays represent the most up-to-date philosophical thinking (...) on timeless scientific topics such as: determinism, explanation, laws of nature, perception, individuality, time, and economics as well as timely topics like adaptation, conservation biology, quantum logic, consciousness, evolutionary psychology, and game theory. (shrink)

Sumit Sarkar, one of the leading Indian historians of his generation, participated in the Indian-British Subaltern Studies Collective that established new standards in the historiography of colonialism in the 1980’s. In this Interview, Déborah Cohen and Urs Lindner ask him about the achievements and oversights of the Subaltern Studies project, the prospects of global history, Marx’s eurocentrism and the problem of religion.

This book provides a richly interdisciplinary assessment of the thought and work of Bryan Norton, one of most innovative and influential environmental philosophers of the past thirty years. In landmark works such as Toward Unity Among Environmentalists and Sustainability: A Philosophy of Adaptive Ecosystem Management, Norton charted a new and highly productive course for an applied environmental philosophy, one fully engaged with the natural and social sciences as well as the management professions. A Sustainable Philosophy gathers together a distinguished group (...) of scholars and professionals from a wide array of fields to engage Norton’s work and its legacy for our shared environmental future. A study in the power of intellectual legacy and the real-world influence of philosophy, the book will be of great interest scholars and students in environmental philosophy, public policy and management, and environmental and sustainability studies. By considering the value and impact of Norton’s body of work it will also chart a course for the next generation of pragmatic environmental philosophers and sustainability scholars grappling with questions of environmental value, knowledge, and practice in a rapidly changing world. (shrink)

Cancer is fast becoming an alarming cause of human death. However, it has been reported that if the disease is detected at an early stage, diagnosed, treated appropriately, the patient has better chances of survival long life. Machine learning technique with feature-selection contributes greatly to the detecting of cancer, because an efficient feature-selection method can remove redundant features. In this paper, a Fuzzy Preference-Based Rough Set (FPRS) blended with Support Vector Machine (SVM) has been applied in order to predict cancer (...) biomarkers for biological and gene expression datasets. Biomarkers are determined by deploying three models of FPRS, namely, Fuzzy Upward Consistency (FUC), Fuzzy Downward Consistency (FLC), and Fuzzy Global Consistency (FGC). The efficiency of the three models with SVM on five datasets is exhibited, and the biomarkers that have been identified from FUC models have been reported. (shrink)

This paper presents a human–robot interaction framework where a robot can infer implicit affective cues of a human and respond to them appropriately. Affective cues are inferred by the robot in real-time from physiological signals. A robot-based basketball game is designed where a robotic “coach” monitors the human participant’s anxiety to dynamically reconfigure game parameters to allow skill improvement while maintaining desired anxiety levels. The results of the above-mentioned anxiety-based sessions are compared with performance-based sessions where in the latter sessions, (...) the game is adapted only according to the player’s performance. It was observed that 79% of the participants showed lower anxiety during anxiety-based session than in the performance-based session, 64% showed a greater improvement in performance after the anxiety-based session and 71% of the participants reported greater overall satisfaction during the anxiety-based sessions. This is the first time, to our knowledge, that the impact of real-time affective communication between a robot and a human has been demonstrated experimentally. (shrink)

Biological diversity - or ‘biodiversity’ - is the degree of variation of life within an ecosystem. It is a relatively new topic of study but has grown enormously in recent years. Because of its interdisciplinary nature the very concept of biodiversity is the subject of debate amongst philosophers, biologists, geographers and environmentalists. The Routledge Handbook of Philosophy of Biodiversity is an outstanding reference source to the key topics and debates in this exciting subject. Comprising twenty-three chapters by a team of (...) international contributors the _Handbook_ is divided into six parts: Historical and sociological contexts, focusing on the emergence of the term and early attempts to measure biodiversity _What is biodiversity? _How should biodiversity be defined? How can biodiversity include entities at the edge of its boundaries, including microbial diversity and genetically engineered organisms? _Why protect biodiversity? _What can traditional environmental ethics_ _contribute to biodiversity?_ _Topics covered include anthropocentrism, intrinsic value, and ethical controversies surrounding the economics of biodiversity _Measurement and methodology: _including decision-theory and conservation, the use of indicators for biodiversity, and the changing use of genetics in biodiversity conservation _Social contexts and global justice: _including conservation and community conflicts and biodiversity and cultural values _Biodiversity and other environmental values_: How does biodiversity relate to other values like ecological restoration or ecological sustainability? Essential reading for students and researchers in philosophy, environmental science and environmental studies, and conservation management, it will also be extremely useful to those studying biodiversity in subjects such as biology and geography. (shrink)

The scope and nature of reductionist explanation in quantum physics is analyzed, with special attention being paid to the situation in quantum physics.

Background and rationale Clinicians often encounter a variety of ethical challenges in their routine clinical practice, and it varies across healthcare and cultural settings of their practice. Despite of this, there are no clear-cut available guidelines concerning the right course of action in a given ethically challenging situation. A validated instrument that could capture the health care providers’ viewpoints in this regard is lacking from Indian settings. Thus, the current study aimed at developing an instrument to assess the HCP’s perspective (...) regarding different ethically challenging situations encountered in the Indian settings. Methods The questionnaire was developed by involving 15 medical experts. A mixed-method approach, Delphi-technique, and online survey were used for item generation and validation. Results The questionnaire comprised of 11 items representing four factors: health-resource constraints, medical responsibility of the HCP, obtaining patients/family members’ consent for the treatment, and treatment beyond the standard protocol. The gender and clinical disciplines of the participants were related to their level of endorsement for various domains of the ECCS-Q. Conclusions Ethical challenges in the clinical practice fall in different clusters. The clinicians’ course of action in such situations have many socio-demographic and professional determinants. Future studies are warranted to investigate these phenomena. (shrink)

Discrete Mathematics is designed to serve as a textbook for undergraduate engineering students of computer science and postgraduate students of computer applications. The book would also prove useful to post graduate students of mathematics. It seeks to provide a thorough understanding of the subject and present its practical applications to computer science.

Habitat dioramas depicting ecological relations between organisms and their natural environments have become the preferred mode of museum display in most natural history museums in North America and Europe. Dioramas emerged in the late nineteenth century as an alternative mode of museum installation from taxonomically arranged cases. We suggest that this change was closely connected to the emergence of a biogeographical framework rooted in evolutionary theory and positing the existence of distinct biogeographical zones. We tie the history of dioramas to (...) earlier visual resources such as the thematic images that Wallace introduced to illustrate his 1876 Geographical Distribution of Animals. These images were unique in their time because each of them simultaneously depicted animals from several different taxa, rather than only one, as well as the ecological relations between animals and their habitats. Both, visually and with respect to their function within biogeography, these images presaged the habitat dioramas that came shortly afterwards. Not coincidentally, Wallace explicitly advocated the use of dioramas for museum display in ongoing debates on museum reform. Wallace 's suggestions were put into practice by committed evolutionists such as Gottlieb von Koch who pioneered the diorama installation in the Grand Ducal Museum in Darmstadt in 1906. As in Wallace 's illustrations, Koch's dioramas were designed to respresent biogeographical zones. This paper explores the function of these visual displays of biogeographical relations. It argues that, in both the scientific and public realms, biogeogaphical zones were defined and constructed by visual means; recourse to visual representation was more than a method of communication. (shrink)

This book explores the epistemological and ethical issues at the foundations of environmental philosophy, emphasising the conservation of biodiversity. Sahota Sarkar criticises attempts to attribute intrinsic value to nature and defends an anthropocentric position on biodiversity conservation based on an untraditional concept of transformative value. Unlike other studies in the field of environmental philosophy, this book is as much concerned with epistemological issues as with environmental ethics. It covers a broad range of topics, including problems of explanation and prediction (...) in traditional ecology and how individual-based models and Geographic Information Systems technology is transforming ecology. Introducing a brief history of conservation biology, Sarkar analyses the consensus framework for conservation planning through adaptive management. He concludes with a discussion of directions for theoretical research in conservation biology and environmental philosophy. (shrink)

A framework is presented in which the role ofdevelopmental rules in phenotypic evolution canbe studied for some simple situations. Usingtwo different implicit models of development,characterized by different developmental mapsfrom genotypes to phenotypes, it is shown bysimulation that developmental rules and driftcan result in directional phenotypic evolutionwithout selection. For both models thesimulations show that the critical parameterthat drives the final phenotypic distributionis the cardinality of the set of genotypes thatmap to each phenotype. Details of thedevelopmental map do not matter. If phenotypesare (...) randomly assigned to genotypes, the lastresult can also be proved analytically. (shrink)

Despite the transformation in biological practice and theory brought about by discoveries in molecular biology, until recently philosophy of biology continued to focus on evolutionary biology. When the Human Genome Project got underway in the late 1980s and early 1990s, philosophers of biology -- unlike historians and social scientists -- had little to add to the debate. In this landmark collection of essays, Sahotra Sarkar broadens the scope of current discussions of the philosophy of biology, viewing molecular biology as (...) a unifying perspective on life that complements that of evolutionary biology. His focus is on molecular biology, but the overriding question behind these papers is what molecular biology contributes to all traditional areas of biological research.Molecular biology -- described with some foresight in a 1938 Rockefeller Foundation report as a branch of science in which "delicate modern techniques are being used to investigate ever more minute details" -- and its modeling strategies apparently argue in favor of physical reductionism. Sarkar's first three chapters explore reductionism -- defending it, but cautioning that reduction to molecular interactions is not necessarily a reduction to genetics. The next sections of the book discuss function, exploring how functional explanations pose a problem for reductionism; the informational interpretation of biology and how it interacts with reductionism; and the tension between the unifying framework of molecular biology and the received framework of evolutionary theory. The concluding chapter is an essay in the emerging field of developmental evolution, exploring what molecular biology may contribute to the transformation of evolutionary theory as evolutionary theory takes into account morphogenetic development. (shrink)

A classification of models of reduction into three categories — theory reductionism, explanatory reductionism, and constitutive reductionism — is presented. It is shown that this classification helps clarify the relations between various explications of reduction that have been offered in the past, especially if a distinction is maintained between the various epistemological and ontological issues that arise. A relatively new model of explanatory reduction, one that emphasizes that reduction is the explanation of a whole in terms of its parts is (...) also presented in detail. Finally, the classification is used to clarify the debate over reductionism in molecular biology. It is argued there that while no model from the category of theory reduction might be applicable in that case, models of explanatory reduction might yet capture the structure of the relevant explanations. (shrink)