Stem cells have the capacity both to self‐renew and to give rise to differentiated progeny, and are vital to the organization of multicellular organisms. Stem cells raise a number of fundamental questions regarding lineage restriction and cellular differentiation, and they hold enormous promise for cell‐based therapies. Here I propose a theoretical framework for stem cell biology based on the concepts of autopoiesis (self‐production) and complementarity. I argue that stem cells are pivotal in the self‐production of the organism and that we (...) need complementary approaches to understand their probabilistic behavior. I discuss how this framework generates testable hypotheses regarding stem‐cell functions. BioEssays 26:1013‐1016, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Transposable elements (TEs) are sequences currently or historically mobile, and are present across all eukaryotic genomes. A growing interest in understanding the regulation and function of TEs has revealed seemingly dichotomous roles for these elements in evolution, development, and disease. On the one hand, many gene regulatory networks owe their organization to the spread of cis‐elements and DNA binding sites through TE mobilization during evolution. On the other hand, the uncontrolled activity of transposons can generate mutations and contribute to disease, (...) including cancer, while their increased expression may also trigger immune pathways that result in inflammation or senescence. Interestingly, TEs have recently been found to have novel essential functions during mammalian development. Here, the function and regulation of TEs are discussed, with a focus on LINE1 in mammals. It is proposed that LINE1 is a beneficial endogenous dual regulator of gene expression and genomic diversity during mammalian development, and that both of these functions may be detrimental if deregulated in disease contexts. (shrink)

We worry about becoming non-existent, but not about coming into being. But both events are similarly bad according to Deprivationism; hence, it seems that we should display symmetric attitudes towards both. This entails the implausible conclusion that we should display negative attitudes towards the time of our birth. In a series of articles Brueckner and Fischer offered one of the most prominent attempts to block this conclusion by appealing to a temporal bias towards future pleasures. Inspired by Yi’s criticism of (...) their view, we argue that there is an appropriate sense of deprivation in which late birth can deprive of future pleasures. Hence, Brueckner and Fischer’s Temporal Bias does not explain the attitudinal asymmetry. In addition, to make sure that one picks out the appropriate sense of deprivation, we offer a restriction, the Historical Condition, that prevents us from considering that every value one would otherwise have is value that one was deprived of due to one’s actual birth/death. Finally, we present a novel account for the attitudinal asymmetry that relies on what we call ‘Interests Proximity Bias’. (shrink)

The use of transcranial Electrical Stimulation in the modulation of cognitive brain functions to improve neuropsychiatric conditions has extensively increased over the decades. tES techniques have also raised new challenges associated with study design, stimulation protocol, functional specificity, and dose-response relationship. In this paper, we addressed challenges through the emerging methodology to investigate the dose-response relationship of High Definition-transcranial Direct Current Stimulation, identifying the role of negative valence in tinnitus perception. In light of the neurofunctional testable framework and tES application, (...) hypotheses were formulated to measure clinical and surrogate endpoints. We posited that conscious pairing adequately pleasant stimuli with tinnitus perception results in correction of the loudness misperception and would be reinforced by concurrent active HD-tDCS on the left Dorsolateral Prefrontal Cortex. The dose-response relationship between HD-tDCS specificity and the loudness perception is also modeled. We conducted a double-blind, randomized crossover pilot study with six recruited tinnitus patients. Accrued data was utilized to design a well-controlled adaptive seamless Bayesian dose-response study. The sample size and optimum interims were anticipated for adaptive decision-making about efficacy, safety, and single session dose parameters. Furthermore, preliminary pilot study results were sufficient to show a significant difference within the longitudinally detected self-report tinnitus loudness between before and under positive emotion induction. This study demonstrated a research methodology used to improve emotion regulation in tinnitus patients. In the projected method, positive emotion induction is essential for promoting functional targeting under HD-tDCS anatomical specificity to indicate the efficacy and facilitate the dose-finding process. The continuous updating of prior knowledge about efficacy and dose during the exploratory stage adapts the anticipated dose-response model. Consequently, the effective dose range to make superiority neuromodulation in correcting loudness misperception of tinnitus will be redefined. Highly effective dose adapts the study to a standard randomized trial and transforms it into the confirmatory stage in which active HD-tDCS protocol is compared with a sham trial. Establishing the HD-tDCS intervention protocols relying on this novel method provides reliable evidence for regulatory agencies to approve or reject the efficacy and safety. Furthermore, this paper supports a technical report for designing multimodality data-driven complementary investigations in emotion regulation, including EEG-driven neuro markers, Stroop-driven attention biases, and neuroimaging-driven brain network dynamics. (shrink)

We leverage insights and theories from the extensive inter-firm alliance literature to explore the effect of the sector of the partners on Firm–NGO alliance governance. Our analysis suggests that the sector of the partners has an important impact on alliance governance, not only because it constrains the availability of some governance mechanisms but also because it makes alternative mechanisms available or relevant to the partners. Specifically, we predict that B2N alliances will rely on contracts, a restricted scope, and non-equity hostages, (...) such as reputational hostages and stakeholder involvement, rather than equity, leading to limited protection against opportunism. As a consequence, B2N alliance partners will need to rely on trust-based governance mechanisms to a greater extent than B2B alliance partners, although trust will be harder to build in B2N alliances. (shrink)

Aiming at a better understanding of the extent to which Africa-focused research has helped develop context-bound, context-specific, and context-free knowledge, the authors present the findings from a literature review of journal articles with an African context. A systematic search resulted in 271 articles with African data and 139 Africa-focused articles published in 63 top business journals and related disciplines from 2010 onwards. The sample included all journals belonging to the University of Texas Dallas and Financial Times research rankings, as well (...) as the main international business, and business and society outlets. An in-depth analysis of the 139 Africa-focused articles shows an important imbalance in terms of publication patterns, topics covered, theoretical groundings, types of contributions, approaches to the African contexts, and empirics. Building on this exhaustive literature review, the authors provide specific suggestions regarding potential data sources and empirical strategies in African contexts, propose avenues for future research, and introduce four recent studies included in the special issue. (shrink)

We leverage insights and theories from the extensive inter-firm alliance literature to explore the effect of the sector of the partners on Firm-NGO (B2N) alliance governance. Our analysis suggests that the sector of the partners has an important impact on alliance governance, not only because it constrains the availability of some governance mechanisms but also because it makes alternative mechanisms available or relevant to the partners. Specifically, we predict that B2N alliances will rely on contracts, a restricted scope, and non-equity (...) hostages, such as reputational hostages and stakeholder involvement, rather than equity, leading to limited protection against opportunism. As a consequence, B2N alliance partners will need to rely on trust-based governance mechanisms to a greater extent than B2B alliance partners, although trust will be harder to build in B2N alliances. (shrink)

The debate about how to solve the paradox of fiction has largely been a debate between Kendall Walton and the so-called thought theorists. In recent years, however, Jenefer Robinson has argued, based on her affective appraisal theory of emotion, for a noncognitivist solution to the paradox as an alternative to the thought theorists’ solution and especially to Walton's controversial solution. In this article, I argue that, despite appearances to the contrary, Robinson's affective appraisal theory is compatible with Walton's solution, at (...) the core of which lies the thesis that there are quasi-emotions. Moreover, since Robinson's theory is compatible with Walton's solution, I show how it can be used as a model to empirically test whether quasi-emotions exist. (shrink)

Sometimes, when comparing a pair of items, it appears that neither is better than the other, nor that they are equally good, relative to a certain value that they bear. Cases of this kind have come to be referred to as superhard comparisons. What grounds superhard comparisons? On the dominant views, held by Joseph Raz and Ruth Chang, they are grounded, at least partially, in the failure of the three classic value relations—‘better than’, ‘worse than’, and ‘equally good’. On an (...) alternative view, which might be called the vagueness view, first developed by John Broome, they are grounded in vagueness about which of the classic value relations holds between the items. In this paper, I pay special attention to superhard comparisons in the context of choice and develop a novel argument against the dominant views on the basis of an account of decision-making under vagueness in ‘better than’. The upshot is that a new vagueness view emerges. (shrink)

Science fiction has been an inexhaustible source for the creation of technoscientific imaginary that has marked certain historical periods and influenced the production of subjectivity. This imaginary evokes complex ontological, epistemological, political, social, environmental and existential questions on the present and the future. The aim of this study was to identify and characterize the cultural productions accessed by the public to form an opinion about the genetic manipulation of human beings. A survey about sources of information that influence opinions on (...) the genetic manipulation of human beings was applied to 360 medical students (70.8% female). Movies were the most commonly mentioned source of information, followed by books, documentaries, news programs, television series, informational videos, soap operas and videogames. Science fiction was the most frequent genre and dystopian views of the future of humanity predominated. (shrink)

We argue that Anthropocentrism – the kind of speciesism that privilegies the human species – is morally unacceptable. We distinguish and criticize three varieties of Anthropocentrism: unqualified, qualified empirical and qualified non-empirical. Firstly, unqualified Anthropocentrism is dismissed because it is grounded on a moral principle which implies that discriminations like racism and sexism are justified. Secondly, qualified empirical Anthropocentrism falls victim to the marginal cases argument, an argument that shows that properties which allegedly attribute moral status to every human and (...) to no animal, ultimately, if they exclude every animal, they also exclude some humans. Lastly, qualified non-empirical Anthropocentrism is rejected due to implausible consequences about which individuals have moral status. After rejecting Anthropocentrism, we consider a generalization of the marginal cases argument against all forms of speciesism. We show that only a species entirely comprised of essentially moral individuals would be unaffected by this argument. However, the possibility of such a species has limited practical import. Contrarily, Anthropocentrism’s moral unacceptability requires profound changes in the way humans relate with animals. (shrink)

A teologia esforça-se por repertoriar e sistematizar o que a revelação e a fé trazem ao crente sobre o problema do sentido da história, da peregrinação através do tempo da humanidade pensada em seu conjunto. Ela enfatiza, não tanto o conhecimento, mas o estado espiritual de felicidade ao qual a humanidade deve ascender antes do fim da vida na terra. Os modernos não aceitam a proposta teológica e têm por ambição descentralizar a história tradicionalmente ordenada por uma visão cristocêntrica do (...) mundo. O historiador, isentando-se da facção, assume o discurso racional sobre a trajetória dos humanos a partir de um novo núcleo referencial interpretativo, a saber, a ideia de humanidade. Voltaire apresenta-se como legítimo representante dessa perspectiva. A história sob o prisma voltairiano é colocada como problema e não como dogmática com características de uma aquisição definitiva. O problema histórico é o de compreender o mundo atual e a humanidade nele inserida. O objetivo, portanto, do trabalho foi apresentar a proposta teológica para a história e a crítica a ela desenvolvida por Voltaire, de forma a evidenciar a originalidade da abordagem moderna do fenômeno histórico. (shrink)

Experimental studies on punishment have sometimes been over-interpreted not only for the reasons Guala lists, but also because of a frequent conflation of proximate and ultimate explanatory levels that Guala's review perpetuates. Moreover, for future analyses we may need a clearer classification of different kinds of punishment.

O Kenkon bensetsu (Tratado e Crítica sobre a Terra e os Céus) é a primeira exposição sistemática sobre os princípios astronómicos e cosmológicos ocidentais que se encontra vertida para japonês. Este texto, composto no Japão por volta de 1650, pelo ex-jesuíta Cristovão Ferreira. consiste na versão japonesa de um Tratado de Esfera ocidental. com abundantes comentários e críticas por um erudito confucionista. No Kenkon bensetsu temos. assim, a circunstância rara de poder analisar, lado a lado, alguns conceitos fundamentais do pensamento (...) ocidental e o modo como foram recebidos pelo pensamento japonês do século XVII. Trata-se portanto de um documento de excepcional valor para se avaliar o intercâmbio cultural e científico entre a Europa e o Extremo Oriente nos séculos XVI-XVII, e é um dos testemunhos mais eloquentes e significativos da influência portuguesa no Japão. /// The Kenhon bensetsu (Treatise and Critic on Earth and Heavens) is the first systematic explanation of the astronomical and cosmological western principles that is translated to japanese. This text was composed in Japan about 1650 by the former Jesuit Cristóvão Ferreira, and is a japanese version of a western Sphere Treatise, including many commentaries and critics by a erudite confucionist. Thus, we have in Kenhon hensetsu the rare possibility to be able to analyse, side by side, both some fundamental concepts of western thought and the way they were received by the XVIIth century japanese thought. This is, therefore, a document of an exceptional relevance in order to evaluate both the scientific and the cultural interchange between Europe and the Far East during the XVIth and the XVIIth centuries. It is also one of the most important and significant testimonies of the portugues influence in Japan. (shrink)

We claim that physics has been constructed because three “philosophical” principles have been respected, namely, realism, locality, and consistency. These principles lead to an interpretation of quantum mechanics (QM) in terms of local hidden-variables theories (LHV). In order to prove that LHV have not been refuted, we analyze the empirical proofs of Bell's inequalities and we argue that none is loophole-free. Then we propose a restricted QM that does not contain measurement postulates and that does not claim that all state (...) vectors (self-adjoint operators) are states (observables). The contradiction of such restricted QM with Bell's inequality cannot be shown as a theorem, but only by the design of a loophole-free experiment. Finally, we argue that noise has been underestimated in quantum theory. It does not appear in QM, but it is essential in quantum field theory. We conjecture that noise will prevent the violation of Bell's inequality. (shrink)

Patina is the word used for the green or brown film formed on the surface of old bronze, an excess of which can mask the true characteristics of the original masterpiece. Filippo Baldinucci used the word patina in a modern sense for first time in his book “Tuscan Vocabulary of the Art of Design”. Metaphors have been part of philosophical speech since the time of Plato. This figure of speech is used to attempt to provide a sensitive presence of an (...) idea to improve understanding and to make a more vivid perception of that concept. On analysing the creative process of contemporary re-search on health topics and its further dissemination, we defend the epistemological thesis that there is always some degree of patina on an original article and this may obscure the underlying scientific work. Conclusion: We consider that patina in scientific papers is very different from the concept of epidemiological bias. We think that any researcher who reads an original article acts as a restorer of knowledge. If a reader is aware of the existence of scientific patina, that reader will know how to look through it and see the masterpiece hidden underneath. (shrink)

Abordagens (etno)filosóficas no e do direito -- Criminologia, direito penal e direito internacional humanitário -- Educação em direitos humanos e fundamentais -- Hermanêutica jurídica e sistemas teóricos do conhecimento no direito -- Gênero na transversalidade no direito : epistemologias da marginalização do 'outro' não hegemônico.

Texto correspondiente a la defensa de la Tesis Doctoral del autor, que lleva por título La escuela jurídica kantiana y la ciencia del derecho en Alemania (1750-1804), en la que se examina el desenvolvimiento coherente del iusnaturalismo inmanentista alemán, a lo largo del periodo ilustrado, en su apelación a la ciencia jurídica (Rechtslehre), por medio de los conceptos a priori de naturaleza e historia.

This paper deals with the questions of emergence and complex (mental and social) systems and with downward determination from the viewpoint of perspectival realism. These are issues concerning the foundations of the human sciences, generally speaking, and particularly psychology and sociology. A criterion is put forward, which distinguish metaphysicalfrom ontological (conceptual) problems, and the notions of complex, hierarchic system and causation that would be suitable for those that defend emergence and perspectivist foundations of the human sciences are discussed. Este artigo (...) trata das questões da emergência de sistemas complexos (mentais e sociais) e da determinação descendente do ponto de vista do realismo perspectivista. Essas são questões sobre os fundamentos das ciências humanas em geral e, em particular, da psicologia e da sociologia. É proposto um critério para distinguir problemas metafísicos de problemas ontológicos (ou conceituais), e são discutidas as noções de sistema complexo hierárquico e de causação que seriam adequadas para uma fundamentação emergentista e perspectivista das ciências humanas. (shrink)

A fibromialgia é uma síndrome crônica, não inflamatória caracterizada por dores musculoesqueléticas difusas e pela presença de pontos dolorosos em determinadas regiões do corpo "Tender Points". Seu diagnóstico é clínico, não havendo alterações laboratoriais específicas. O enfoque deste trabalho é co..

Este relato de experiência traz quatro depoimentos de três alunos/a e um professor do programa de pós-graduação stricto sensu em Ensino de História da África do Instituto Superior de Ciências de Educação, situado no sudoeste angolano. Pretende-se acompanhar as trajetórias pessoais destes pesquisadores em torno do ensino e pesquisa em história da África, tanto em Angola quanto no Brasil.

Despite the various perceptual-motor deficits documented in strabismus, there is a paucity of studies evaluating visual illusions in patients with strabismus. The aim of this study was to examine how the illusionary perception occurs in children/adolescents with strabismus with referral for surgery to correct ocular deviations. A controlled cross-sectional study was carried out in which 45 participants with strabismus and 62 healthy volunteers aged 10–15 years were evaluated. The behavioral response to three geometric illusions [Vertical-Horizontal illusion, Müller-Lyer illusion and Ponzo (...) illusion] and respective neutral stimuli regarding the estimation of image size and response time were measured using the Method of Adjustment. To analyze the influence of secondary factors: type of ocular deviation ; amount of eye deviation; presence of amblyopia and stereopsis, a one-way ANOVA was performed. Among the tested illusions, children with strabismus showed greater susceptibility and response time to Ponzo’s illusory images. Children with strabismus and preserved stereopsis, on the other hand, showed similar susceptibility and response time to control group patients to the Ponzo illusion. Patients with amblyopia showed overcorrection in the estimate of non-illusory Ponzo images. Children with horizontal ocular deviation associated with vertical deviation showed higher susceptibility to vertical adjustment images for the Müller-Lyer illusion. Individuals with strabismus tended to overcorrect the length of the straight-line segment adjusted for non-illusory images when testing non-illusory images in the Müller-Lyer test, as well as for the neutral images in the Vertical-Horizontal test. The findings indicated impairment in the perception of geometric illusions and neutral figures, especially for the Ponzo illusion test by children with strabismus. As the behavioral response to illusory images may indirectly reflect the visual and morphofunctional alterations present in these individuals, we suggest that the investigation of visual illusory perception can be used as a new research strategy in the field of investigating the visual function in strabismus. (shrink)

In this paper will show the terms in that is presented the Reinvention of Social Emancipation in the critical platform of the Portuguese author Boaventura de Sousa Santos.

Resumen Las concepciones de hombre y trabajo están íntimamente interconectadas dentro del pensamiento de Miguel de Unamuno. La persona, sin reducirse a ninguna forma de instrumentalización política y económica, no es un mero medio, sino un fin en sí misma. Unamuno no escamotea su lucha en contra del capitalismo y de la transformación de lo económico y de lo político en mero valor de cambio. No nos extraña, pues, que nuestro autor, no conformándose con los efectos del materialismo mercantilista, (...) proponga unas concepciones de política y de sociedad más humanas capaces de dignificar la vida de cada hombre concreto de carne y hueso. Es en este marco teórico-conceptual en el que Unamuno conceptualiza el trabajo como vocación y como forma de realización humana, desvinculándolo de la perspectiva mercantilista vigente en su época. El propósito del presente estudio es, pues, descubrir la íntima relación que une la concepción unamuniana de hombre con su concepción del trabajo como forma de formación y libertad humanas.The conceptions of man and work are intimately related in the thought of Miguel de Unamuno. The person, not reduced to any form of political or economic exploitation, is not a mere means but rather an end in itself. Unamuno does not shirk from his struggle against capitalism and the transformation of economics and politics to mere exchange value. It is not surprising therefore that our author, not content with the effects of mercantilist materialism, should propose a more human conception of politics and society capable of dignifying the life of each specific man of flesh and blood. Within this theoretical-conceptual frame, Unamuno conceptualizes work as vocation and as a form of human fulfilment, disassociating it from the mercantilist perspective that prevailed in his time. The purpose of the present study is thus to uncover the intimate relation that joins Unamuno’s conception of man with his conception of work as a form of human education and freedom. (shrink)

Victoria Espinosa Santos es miembro de la Academia Chilena de la Lengua desde 2017 y forma parte de la Comisión de Lexicografía. Esta entrevista, realizada de forma virtual el 6 de julio de 2021, se concentra en los siguientes temas: las variaciones del español de América, el rol de las lenguas indígenas en el español de Chile, el trabajo de las academias de la Lengua Española, el rol de las academias en relación con la lingüística y la literatura.

En este estudio, que intenta analizar la relación que Unamuno mantuvo con las pedagogías vigentes en España a finales del siglo XIX y principios del XX, procuraremos determinar los aspectos que han alejado al insigne rector salmantino de los métodos pedagógicos de los jesuitas (emulación), de la escolástica (retórica) y de las Escuelas del Avemaría (juego), que, como es bien sabido, han estructurado la enseñanza en España durante el susodicho período. Pero, más allá de su enfoque histórico, este estudio permitirá (...) también la comprensión filosófica de lo que es la educación, y la tarea de educar, que, según su peculiar visión pedagógica, debe estructurarse bajo un horizonte espiritual, donde profesor y alumno se han de concebir como padre e hijo en espíritu. Unamuno, al definir de este modo los agentes del acto educativo, terminó por determinar la formación ético normativa de la persona como telos pedagógico por excelencia de la escuela. No nos extraña, pues, que don Miguel se haya alejado del ideal educativo alemán (Fachmann), el del doctor especialista, a favor del ideal educativo inglés (Gentleman), que ha aceptado sin reservas como eje filosófico de su pensamiento educativo. (shrink)

Este artículo se enmarca en el proyecto de investigación de la Maestría en Filosofía Latinoamericana, Bartolomé de Las Casas: Recepción de la filosofía analítica en Colombia y Latinoamérica de la Universidad Santo Tomás. Inicialmente fue redactado en inglés: The Quest for the Numbers: An Approach to Frege’s Philosophy, cuyo trabajo pretende acercarse al fundamento de la obra fregeana como hito fundamental del pensamiento filosófico; asimismo, desarrolla en detalle los temas y puntos más relevantes de su sistema de pensamiento. A partir (...) de un análisis del proyecto logicista, es decir, la búsqueda de una reducción de la matemática a la lógica, se demuestran las fuertes influencias del pensamiento de Frege en todas las ramas de la filosofía contemporánea. La comprensión de la filosofía de Frege entonces constituye un paso fundamental, para tener un horizonte acerca de las problemáticas de la filosofía en la actualidad y, asimismo, un fundamento o propedéutica para el desarrollo de un pensamiento latinoamericano maduro en diálogo con la tradición. (shrink)

El presente estudio intenta poner de relieve la posición filosófica de don Miguel frente a la “ciencia” y la “religión”. El insigne rector salmantino, al partir del hecho de que la “ciencia” no puede satisfacer las últimas inquietudes y aspiraciones vitales de la existencia humana, presentó la “religión” como único movimiento espiritual capaz de otorgar un sentido ultraterreno al hombre, irremediablemente abocado a la muerte terrenal. Su tesis podría ser condensada en la siguiente proposición: ninguna “sociedad perfecta”, sea entendida (...) como la de Bebel o la de Kropotkine, puede ser una medicina para la muerte. Precisamente, por ello, justificó la existencia y sentido de la “religión” como respuesta más anhelada al tremendo problema de la precariedad y de la finitud de la existencia humana. (shrink)

El presente estudio intenta poner de relieve la posición filosófica de don Miguel frente a la “ciencia” y la “religión”. El insigne rector salmantino, al partir del hecho de que la “ciencia” no puede satisfacer las últimas inquietudes y aspiraciones vitales de la existencia humana, presentó la “religión” como único movimiento espiritual capaz de otorgar un sentido ultraterreno al hombre, irremediablemente abocado a la muerte terrenal. Su tesis podría ser condensada en la siguiente proposición: ninguna “sociedad perfecta”, sea entendida (...) como la de Bebel o la de Kropotkine, puede ser una medicina para la muerte. Precisamente, por ello, justificó la existencia y sentido de la “religión” como respuesta más anhelada al tremendo problema de la precariedad y de la finitud de la existencia humana. (shrink)

Resumen El sentimiento trágico de la vida fue una de las grandes aportaciones filosófico-religiosas de don Miguel de Unamuno. Si es cierto que, al lado de su concepción trágica de la existencia, se yuxtaponen conceptos tan fundamentales y decisivos como los de conatus essendi, lucha por la vida, fe y Dios, en el presente estudio nos ceñiremos a la relación polémica y angustiada que la pistis mantiene con la gnosis o, si se quiere, que la fe mantiene con la (...) razón en cuanto al destino último de las conciencias individuales. Con ello intentaremos poner de relieve los rasgos más característicos y simbólicos de la existencia humana así como la conceptualizó Unamuno en su época finisecular decimonónica, cuando el positivismo y la fenomenología impugnaban la metafísica como rama legítima del conocimiento.The Tragic Sense of Life was one of Miguel de Unamuno’s great philosophical-religious contributions. It is true that next to his tragic conception of existence we find juxtaposed concepts as fundamental and decisive as those of conatus essendi, life struggle, faith and God, but, while admitting these, in the present study we address only the polemical and anguished relation that pistis has with gnosis, or in other words, that faith has with reason, in relation to the ultimate fate of individual consciences. Thus we attempt to highlight the most characteristic and symbolic traits of human existence as conceptualized by Unamuno at the turn of the 19th to the 20th century, when positivism and phenomenology seemed to challenge metaphysics as a legitimate branch of knowledge. (shrink)