Results for 'Douglas Kell'

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  1. Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis‐driven science in the post‐genomic era.Douglas B. Kell & Stephen G. Oliver - 2004 - Bioessays 26 (1):99-105.
    It is considered in some quarters that hypothesis‐driven methods are the only valuable, reliable or significant means of scientific advance. Data‐driven or ‘inductive’ advances in scientific knowledge are then seen as marginal, irrelevant, insecure or wrong‐headed, while the development of technology—which is not of itself ‘hypothesis‐led’ (beyond the recognition that such tools might be of value)—must be seen as equally irrelevant to the hypothetico‐deductive scientific agenda. We argue here that data‐ and technology‐driven programmes are not alternatives to hypothesis‐led studies in (...)
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  2.  70
    Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments?Douglas B. Kell - 2012 - Bioessays 34 (3):236-244.
    A considerable number of areas of bioscience, including gene and drug discovery, metabolic engineering for the biotechnological improvement of organisms, and the processes of natural and directed evolution, are best viewed in terms of a ‘landscape’ representing a large search space of possible solutions or experiments populated by a considerably smaller number of actual solutions that then emerge. This is what makes these problems ‘hard’, but as such these are to be seen as combinatorial optimisation problems that are best attacked (...)
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  3.  26
    On the role of enzyme kinetic parameters in determining the effectiveness with which channelling can decrease the size of a metabolite pool.Pedro Mendes & Douglas B. Kell - 1993 - Acta Biotheoretica 41 (1-2):63-73.
    Recently, it has been argued that the phenomenon of direct transfer of intermediate metabolites between adjacent enzymes, also known as metabolic channelling, would not decrease the concentration of those intermediates in the bulk solution. However, this conclusion has been drawn by extrapolation from the results of simulations with a rather restricted set of parameters. We show that, for a number of kinetic cases, the existence of metabolic channelling can decrease the size of the soluble pool of intermediates. When the enzyme(s) (...)
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  4. Functional genomic hypothesis generation and experimentation by a robot scientist.Ross King, Whelan D., E. Kenneth, Ffion Jones, Reiser M., G. K. Philip, Christopher Bryant, Muggleton H., H. Stephen, Douglas Kell, Oliver B. & G. Stephen - 2004 - Nature 427 (6971):247--52.
  5.  18
    From Karl von Frisch to Neuroethology: A Methodological Perspective on the Frischean Tradition's Expansion into Neuroethology*.Kelle Dhein - 2022 - Berichte Zur Wissenschaftsgeschichte 45 (1-2):30-54.
    Berichte zur Wissenschaftsgeschichte, EarlyView.
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  6.  9
    Extraterrestrial altruism: evolution and ethics in the cosmos.Douglas A. Vakoch (ed.) - 2014 - New York: Springer.
    Extraterrestrial Altruism examines a basic assumption of the Search for Extraterrestrial Intelligence (SETI): that extraterrestrials will be transmitting messages to us for our benefit. This question of whether extraterrestrials will be altruistic has become increasingly important in recent years as SETI scientists have begun contemplating transmissions from Earth to make contact. Technological civilizations that transmit signals for the benefit of others, but with no immediate gain for themselves, certainly seem to be altruistic. But does this make biological sense? Should we (...)
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  7.  30
    Structural connectivity of left cortical speech regions defined by direct cortical stimulation during awake language mapping.Kell Christian, Hok Pavel, Fuhrmann Silke, Kropff Ines, Forster Marie-Therese, Senft Christian & Seifert Volker - 2015 - Frontiers in Human Neuroscience 9.
  8. Kantsequentialism and Agent-Centered Restrictions.Douglas W. Portmore - manuscript
    There are two alternative approaches to accommodating an agent-centered restriction against, say, φ-ing. One approach is to prohibit agents from ever φ-ing. For instance, there could be an absolute prohibition against breaking a promise. The other approach is to require agents both to adopt an end that can be achieved only by their not φ-ing and to give this end priority over that of minimizing overall instances of φ-ing. For instance, each agent could be required both to adopt the end (...)
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  9.  16
    Insight-imagination: the emancipation of thought and the modern world.Douglas Sloan - 1983 - San Rafael, CA: Barfield Press.
    Fragmented thinking, broken world -- Toward recovery of wholeness: the radical humanities and traditional wisdom -- Toward recovery of wholeness: another look at science -- Insight-imagination -- Living thinking, living world: toward an education of insight-imagination.
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  10.  4
    Culturology: Treatments and conceptions.Kelle V. Zh - 2003 - Russian Studies in Philosophy 41 (4):79-82.
    I recently heard a presentation by E. V. Semenov, the director of the Russian State Science Foundation. He said that culturology has not been included in the Foundation's rubrication. There are grants, but there is no rubric, because so far culturology is an extremely fluid area, and very diverse topics are relegated to it. Aleksei Iur'evich [Shemanov] is quite right when he says that "the process of shaping culturology into a special discipline" is still under way. In such conditions, it (...)
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  11. Fundamentals of Critical Argumentation.Douglas Walton - 2005 - New York: Cambridge University Press.
    Fundamentals of Critical Argumentation presents the basic tools for the identification, analysis, and evaluation of common arguments for beginners. The book teaches by using examples of arguments in dialogues, both in the text itself and in the exercises. Examples of controversial legal, political, and ethical arguments are analyzed. Illustrating the most common kinds of arguments, the book also explains how to evaluate each kind by critical questioning. Douglas Walton shows how arguments can be reasonable under the right dialogue conditions (...)
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  12.  9
    Karl von Frisch and the Discipline of Ethology.Kelle Dhein - 2021 - Journal of the History of Biology 54 (4):739-767.
    In 1973, the discipline of ethology came into its own when three of its most prominent practitioners—Konrad Lorenz, Nikolaas Tinbergen, and Karl von Frisch—jointly received the Nobel Prize for Physiology or Medicine. Historians have shown how Lorenz and Tinbergen were central to the practical and theoretical innovations that came to define ethology as a distinct form of animal behavior research in the twentieth century. Frisch is rarely mentioned in such histories. In this paper, I ask, What is Frisch’s relationship to (...)
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  13.  9
    Relevance in Argumentation.Douglas N. Walton - 2004 - Routledge.
    Vol. presents a method for critically evaluating relevance in arguments based on case studies & a new relevance theory incorporating techniques of argumentation theory, logic & artificiaI intelligence. For scholars/students in argumentation & rhetoric.
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  14.  16
    What makes neurophysiology meaningful? Semantic content ascriptions in insect navigation research.Kelle Dhein - 2020 - Biology and Philosophy 35 (5):1-22.
    In the course of investigating the living world, biologists regularly attribute semantic content to the phenomena they study. In this paper, I examine the case of a contemporary research program studying the navigation behaviors of ants and develop an account of the norms governing researchers’ ascriptions of semantic content in their research practices. The account holds that researchers assign semantic content to behaviors that reliably achieve a difficult goal-directed function, and it also suggests a productive role for attributions of semantic (...)
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  15.  8
    Multiscale Modeling in Neuroethology: The Significance of the Mesoscale.Kelle Dhein & Julia R. S. Bursten - forthcoming - Philosophy of Science:1-17.
    Recent accounts of multiscale modeling investigate ontic and epistemic constraints imposed by relations between component models at varying relative scales (macro, meso, micro). These accounts often focus especially on the role of the meso, or intermediate, relative scale in a multiscale model. We aid this effort by highlighting a novel role for mesoscale models: they can function as a focal point, and rationale, for disagreement between researchers who otherwise share theoretical commitments. We illustrate with a case study in multiscale modeling (...)
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  16. Control, Attitudes, and Accountability.Douglas W. Portmore - forthcoming - In David Shoemaker (ed.), Oxford studies in agency and responsibility. Oxford, UK: Oxford University Press.
    It seems that we can be directly accountable for our reasons-responsive attitudes—e.g., our beliefs, desires, and intentions. Yet, we rarely, if ever, have volitional control over such attitudes, volitional control being the sort of control that we exert over our intentional actions. This presents a trilemma: (Horn 1) deny that we can be directly accountable for our reasons-responsive attitudes, (Horn 2) deny that φ’s being under our control is necessary for our being directly accountable for φ-ing, or (Horn 3) deny (...)
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  17.  9
    The cognitive map debate in insects: A historical perspective on what is at stake.Kelle Dhein - 2023 - Studies in History and Philosophy of Science Part A 98 (C):62-79.
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  18. Sensory modalities and novel features of perceptual experiences.Douglas C. Wadle - 2020 - Synthese 198 (10):9841-9872.
    Is the flavor of mint reducible to the minty smell, the taste, and the menthol-like coolness on the roof of one’s mouth, or does it include something over and above these—something not properly associated with any one of the contributing senses? More generally, are there features of perceptual experiences—so-called novel features—that are not associated with any of our senses taken singly? This question has received a lot of attention of late. Yet surprisingly little attention has been paid to the question (...)
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  19.  79
    Age preferences in mates reflect sex differences in human reproductive strategies.Douglas T. Kenrick & Richard C. Keefe - 1992 - Behavioral and Brain Sciences 15 (1):75-91.
    The finding that women are attracted to men older than themselves whereas men are attracted to relatively younger women has been explained by social psychologists in terms of economic exchange rooted in traditional sex-role norms. An alternative evolutionary model suggests that males and females follow different reproductive strategies, and predicts a more complex relationship between gender and age preferences. In particular, males' preferences for relatively younger females should be minimal during early mating years, but should become more pronounced as the (...)
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  20. Desert, Control, and Moral Responsibility.Douglas W. Portmore - 2019 - Acta Analytica 34 (4):407-426.
    In this paper, I take it for granted both that there are two types of blameworthiness—accountability blameworthiness and attributability blameworthiness—and that avoidability is necessary only for the former. My task, then, is to explain why avoidability is necessary for accountability blameworthiness but not for attributability blameworthiness. I argue that what explains this is both the fact that these two types of blameworthiness make different sorts of reactive attitudes fitting and that only one of these two types of attitudes requires having (...)
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  21. Informal Logic: A Pragmatic Approach.Douglas Walton - 2008 - New York: Cambridge University Press.
    Second edition of the introductory guidebook to the basic principles of constructing sound arguments and criticising bad ones. Non-technical in approach, it is based on 186 examples, which Douglas Walton, a leading authority in the field of informal logic, discusses and evaluates in clear, illustrative detail. Walton explains how errors, fallacies, and other key failures of argument occur. He shows how correct uses of argument are based on sound strategies for reasoned persuasion and critical responses. This edition takes into (...)
     
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  22.  14
    Can negative emotions increase students’ plagiarism and cheating?Guy J. Curtis, Kell Tremayne, Kit Wing Fu & Isabeau K. Tindall - 2021 - International Journal for Educational Integrity 17 (1).
    The challenges of higher education can be stressful, anxiety-producing, and sometimes depressing for students. Such negative emotions may influence students’ attitudes toward assessment, such as whether it is perceived as acceptable to engage in plagiarism. However, it is not known whether any impact of negative emotions on attitudes toward plagiarism translate into actual plagiarism behaviours. In two studies conducted at two universities, we examined whether negative emotionality influenced plagiarism behaviour via attitudes, norms, and intentions as predicted by the theory of (...)
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  23. A Comprehensive Account of Blame: Self-Blame, Non-Moral Blame, and Blame for the Non-Voluntary.Douglas W. Portmore - 2022 - In Andreas Carlsson (ed.), Self-Blame and Moral Responsibility. New York, USA: Cambridge University Press.
    Blame is multifarious. It can be passionate or dispassionate. It can be expressed or kept private. We blame both the living and the dead. And we blame ourselves as well as others. What’s more, we blame ourselves, not only for our moral failings, but also for our non-moral failings: for our aesthetic bad taste, gustatory self-indulgence, or poor athletic performance. And we blame ourselves both for things over which we exerted agential control (e.g., our voluntary acts) and for things over (...)
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  24. Legal paternalism.Douglas N. Husak - 2003 - In Hugh LaFollette (ed.), The Oxford handbook of practical ethics. New York: Oxford University Press. pp. 387--388.
  25.  63
    The Scientist’s Education and a Civic Conscience.Kelling J. Donald & Jeffrey Kovac - 2013 - Science and Engineering Ethics 19 (3):1229-1240.
    A civic science curriculum is advocated. We discuss practical mechanisms for (and highlight the possible benefits of) addressing the relationship between scientific knowledge and civic responsibility coextensively with rigorous scientific content. As a strategy, we suggest an in-course treatment of well known (and relevant) historical and contemporary controversies among scientists over science policy or the use of sciences. The scientific content of the course is used to understand the controversy and to inform the debate while allowing students to see the (...)
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  26. Consequentialism.Douglas W. Portmore - 2023 - In Christian B. Miller (ed.), The Bloomsbury Handbook of Ethics. Bloomsbury Academic.
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  27. Moral Worth and Our Ultimate Moral Concerns.Douglas W. Portmore - forthcoming - Oxford Studies in Normative Ethics.
    Some right acts have what philosophers call moral worth. A right act has moral worth if and only if its agent deserves credit for having acted rightly in this instance. And I argue that an agent deserves credit for having acted rightly if and only if her act issues from an appropriate set of concerns, where the appropriateness of these concerns is a function what her ultimate moral concerns should be. Two important upshots of the resulting account of moral worth (...)
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  28.  59
    Methods of Argumentation.Douglas Walton - 2013 - New York, NY: Cambridge University Press.
    Argumentation, which can be abstractly defined as the interaction of different arguments for and against some conclusion, is an important skill to learn for everyday life, law, science, politics and business. The best way to learn it is to try it out on real instances of arguments found in everyday conversational exchanges and legal argumentation. The introductory chapter of this book gives a clear general idea of what the methods of argumentation are and how they work as tools that can (...)
  29. Slippery slope arguments.Douglas N. Walton - 1992 - New York: Oxford University Press.
    A "slippery slope argument" is a type of argument in which a first step is taken and a series of inextricable consequences follow, ultimately leading to a disastrous outcome. Many textbooks on informal logic and critical thinking treat the slippery slope argument as a fallacy. Walton argues that used correctly in some cases, they can be a reasonable type of argument to shift a burden of proof in a critical discussion, while in other cases they are used incorrectly. Walton identifies (...)
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  30. Media Argumentation: Dialectic, Persuasion and Rhetoric.Douglas Walton - 2007 - New York: Cambridge University Press.
    Media argumentation is a powerful force in our lives. From political speeches to television commercials to war propaganda, it can effectively mobilize political action, influence the public, and market products. This book presents a new and systematic way of thinking about the influence of mass media in our lives, showing the intersection of media sources with argumentation theory, informal logic, computational theory, and theories of persuasion. Using a variety of case studies that represent arguments that typically occur in the mass (...)
     
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  31.  76
    Nietzsche's The birth of tragedy: a reader's guide.Douglas Burnham - 2010 - New York: Continuum. Edited by Martin Jesinghausen.
    Introduction -- Context -- Overview of themes -- Reading the text -- Reception and influence.
  32.  88
    Witness testimony evidence: argumentation, artificial intelligence, and law.Douglas Walton - 2007 - New York: Cambridge University Press.
    Recent work in artificial intelligence has increasingly turned to argumentation as a rich, interdisciplinary area of research that can provide new methods related to evidence and reasoning in the area of law. Douglas Walton provides an introduction to basic concepts, tools and methods in argumentation theory and artificial intelligence as applied to the analysis and evaluation of witness testimony. He shows how witness testimony is by its nature inherently fallible and sometimes subject to disastrous failures. At the same time (...)
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  33. Archetypes of wisdom: an introduction to philosophy.Douglas J. Soccio - 1995 - Belmont, CA: Wadsworth/Cengage Learning.
    This reader-friendly book examines philosophies and philosophers using an engaging, non-condescending approach that speaks to you at your level.
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  34.  60
    The Eligibility of Ethical Naturalism.Douglas Edwards - 2013 - Pacific Philosophical Quarterly 94 (1):1-18.
    Perhaps the two main contemporary formulations of ethical naturalism – Synthetic Ethical Naturalism (SEN) and Analytical Descriptivism – seem to conflict with plausible views about cases where moral debate and disagreement is possible. Both lack safeguards to avoid divergence of reference across different communities, which can scupper the prospects for genuine moral disagreement. I explore the prospects for supplementing both views with Lewis's notion of eligibility, arguing that this can solve the problem for a modified form of analytical descriptivism, and (...)
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  35. Consequentialism and Moral Rationalism.Douglas W. Portmore - 2011 - In Mark Timmons (ed.), Oxford Studies in Normative Ethics. Oxford University Press.
    IN THIS PAPER, I make a presumptive case for moral rationalism: the view that agents can be morally required to do only what they have decisive reason to do, all things considered. And I argue that this view leads us to reject all traditional versions of act‐consequentialism. I begin by explaining how moral rationalism leads us to reject utilitarianism.
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  36.  5
    Encounters of mind: luminosity and personhood in Indian and Chinese thought.Douglas L. Berger - 2014 - Albany: SUNY Press.
    Discusses the journey of Buddhist ideas on awareness and personhood from India to China. Encounters of Mind explores a crucial step in the philosophical journey of Buddhism from India to China, and what influence this step, once taken, had on Chinese thought in a broader scope. The relationship of concepts of mind, or awareness, to the constitution of personhood in Chinese traditions of reflection was to change profoundly after the Cognition School of Buddhism made its way to China during the (...)
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  37. Morality and Practical Reasons.Douglas W. Portmore - 2021 - Cambridge, United Kingdom: Cambridge University Press.
    As Socrates famously noted, there is no more important question than how we ought to live. The answer to this question depends on how the reasons that we have for living in various different ways combine and compete. To illustrate, suppose that I've just received a substantial raise. What should I do with the extra money? I have most moral reason to donate it to effective charities but most self-interested reason to spend it on luxuries for myself. So, whether I (...)
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  38. Government Policy Experiments and the Ethics of Randomization.Douglas MacKay - 2020 - Philosophy and Public Affairs 48 (4):319-352.
    Governments are increasingly using randomized controlled trials (RCTs) to evaluate policy interventions. RCTs are often understood to provide the highest quality evidence regarding the causal efficacy of an intervention. While randomization plays an essential epistemic role in the context of policy RCTs however, it also plays an important distributive role. By randomly assigning participants to either the intervention or control arm of an RCT, people are subject to different policies and so, often, to different types and levels of benefits. In (...)
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  39. Marcuse and the Quest for radical subjectivity.Douglas Kellner - 2004 - In John Abromeit & W. Mark Cobb (eds.), Herbert Marcuse: a critical reader. New York: Routledge.
     
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  40. The Copycat Project.Douglas Hofstadter & Melanie Mitchell - 1995 - In Douglas Hofstadter & Melanie Mitchell (eds.), Fluid Concepts and Creative Analogies.
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  41.  86
    Metodologia e análise filosófica da ciência em Larry Laudan.Douglas Antonio Bassani, Cléria Maria Wendling & Osbaldo Washington Turpo Gebera - 2024 - ARGUMENTOS - Revista de Filosofia 31:205-217.
    Esta pesquisa analisa alguns tópicos sobre a metodologia de acordo com a filosofia da ciência de Larry Laudan, além de examinar, na área da educação, esta proposta de interpretação filosófica. Trouxemos como elementos algumas considerações e definições sobre a metodologia em Laudan, isto é, da metodologia como um instrumento para a realização da axiologia (que são as metas e os valores cognitivos), porém, apresentando também interessantes relações para com as teorias específicas, como o de justificar as teorias específicas e de (...)
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  42.  47
    Berkeley's philosophy of mathematics.Douglas M. Jesseph - 2005 - In Kenneth P. Winkler (ed.), The Cambridge Companion to Berkeley. New York: Cambridge University Press. pp. 126-128.
    The dissertation is a detailed analysis of Berkeley's writings on mathematics, concentrating on the link between his attack on the theory of abstract ideas and his philosophy of mathematics. Although the focus is on Berkeley's works, I also trace the important connections between Berkeley's views and those of Isaac Barrow, John Wallis, John Keill, and Isaac Newton . The basic thesis I defend is that Berkeley's philosophy of mathematics is a natural extension of his views on abstraction. The first chapter (...)
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  43. A Policy of No Interest? The Permanent Zero Interest Rate, and the Evils of Capitalism.Alexander Douglas - manuscript
    In 1937 Joan Robinson proposed that “when capitalism is rightly understood, the rate of interest will be set at zero and the major evils of capitalism will disappear”. A permanent zero rate would abolish capitalist profit except in limited cases, leaving nearly all output to be claimed by labour as wages. It would allow capital to be allocated on the basis of prospective social benefit rather than short-term profitability and a collateral basis that favours the wealthy. It would remove some (...)
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  44.  75
    Aidōs: The Psychology and Ethics of Honour and Shame in Ancient Greek Literature.Douglas L. Cairns - 1993 - Oxford: Oxford University Press.
    Introduction; Aidos in Homer; From Hesiod to the Fifth Century; Aeschylus; Sophocles; Euripides; The Sophists, Plato, and Aristotle; References; Glossary; Index of Principal Passages; General Index.
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  45.  22
    Cultural Analysis: The Work of Peter L. Berger, Mary Douglas, Michel Foucault, and Jürgen Habermas.Mary Douglas, Robert Wuthnow, James Davison Hunter, Albert Bergesen & Edith Kurzweil - 1984 - Boston ; London : Routledge & Kegan Paul.
    First published in 1984, Cultural Analysis is a systematic examination of the theories of culture contained in the writings of four contemporary social theorists: Peter L. Berger, Mary Douglas, Michel Foucault, and Jürgen Habermas. This study of their work clarifies their contributions to the analysis of culture and shows the converging assumptions that the authors believe are laying the foundation for a new approach to the study of culture. The focus is specifically on culture, a concept that remains subject (...)
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  46.  10
    Electoral Reckonings: Press Criticism of Presidential Campaign Coverage, 2000-2016.Elizabeth Bent, Kimberly Kelling & Ryan J. Thomas - 2020 - Journal of Media Ethics 35 (2):96-111.
    The cyclical nature of presidential elections provides regular opportunities for journalists to reflect on patterns in election coverage. This study presents a textual analysis of press criticism o...
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  47. What’s a rational self-torturer to do?Douglas W. Portmore - manuscript
    This paper concerns Warren Quinn’s famous “The Puzzle of the Self-Torturer.” I argue that even if we accept his assumption that practical rationality is purely instrumental such that what he ought to do is simply a function of how the relevant options compare to each other in terms of satisfying his actual preferences that doesn’t mean that every explanation as to why he shouldn’t advance to the next level must appeal to the idea that so advancing would be suboptimal in (...)
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  48.  48
    Ethical insights: a brief introduction.Douglas Birsch - 2002 - Boston: McGraw Hill.
    This is a brief, accessible, affordable supplement for any applied ethics course. The text covers eight ethical theories, with each chapter focusing on a key ethical insight that helps establish moral guidelines to solve ethical problems.
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  49.  13
    Designation, characterization, and theory in Dewey's logic.Douglas Browning - 2002 - In F. Thomas Burke, D. Micah Hester & Robert B. Talisse (eds.), Dewey's logical theory: new studies and interpretations. Nashville: Vanderbilt University Press. pp. 160--179.
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  50.  15
    Economics and ethics: an introduction to theory, institutions, and policy.Douglas Vickers - 1997 - Westport, Conn.: Praeger.
    He addresses three main issues: first, the historical means by which economics has consciously surrendered its original association with ethical categories and criteria; second, the need to articulate the appropriate thoughtforms and vocabulary of ethical theory; and third, the illustration of areas in economics where ethical awareness is desirable and should be allowed to exert influence.
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