Results for 'Brendan Clarke'

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  1.  90
    The Evidence that Evidence-based Medicine Omits.Brendan Clarke, Donald Gillies, Phyllis Illari, Federica Russo & Jon Williamson - unknown
    According to current hierarchies of evidence for EBM, evidence of correlation is always more important than evidence of mechanisms when evaluating and establishing causal claims. We argue that evidence of mechanisms needs to be treated alongside evidence of correlation. This is for three reasons. First, correlation is always a fallible indicator of causation, subject in particular to the problem of confounding; evidence of mechanisms can in some cases be more important than evidence of correlation when assessing a causal claim. Second, (...)
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  2. Mechanisms and the Evidence Hierarchy.Brendan Clarke, Donald Gillies, Phyllis Illari, Federica Russo & Jon Williamson - 2014 - Topoi 33 (2):339-360.
    Evidence-based medicine (EBM) makes use of explicit procedures for grading evidence for causal claims. Normally, these procedures categorise evidence of correlation produced by statistical trials as better evidence for a causal claim than evidence of mechanisms produced by other methods. We argue, in contrast, that evidence of mechanisms needs to be viewed as complementary to, rather than inferior to, evidence of correlation. In this paper we first set out the case for treating evidence of mechanisms alongside evidence of correlation in (...)
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  3. Causality in medicine with particular reference to the viral causation of cancers.Brendan Clarke - 2011 - Dissertation, University College London
    In this thesis, I give a metascientific account of causality in medicine. I begin with two historical cases of causal discovery. These are the discovery of the causation of Burkitt’s lymphoma by the Epstein-Barr virus, and of the various viral causes suggested for cervical cancer. These historical cases then support a philosophical discussion of causality in medicine. This begins with an introduction to the Russo- Williamson thesis (RWT), and discussion of a range of counter-arguments against it. Despite these, I argue (...)
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  4. Modelling mechanisms with causal cycles.Brendan Clarke, Bert Leuridan & Jon Williamson - 2014 - Synthese 191 (8):1-31.
    Mechanistic philosophy of science views a large part of scientific activity as engaged in modelling mechanisms. While science textbooks tend to offer qualitative models of mechanisms, there is increasing demand for models from which one can draw quantitative predictions and explanations. Casini et al. (Theoria 26(1):5–33, 2011) put forward the Recursive Bayesian Networks (RBN) formalism as well suited to this end. The RBN formalism is an extension of the standard Bayesian net formalism, an extension that allows for modelling the hierarchical (...)
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  5. Causation in medicine.Brendan Clarke - 2011 - In Wenceslao J. González (ed.), Conceptual Revolutions: from Cognitive Science to Medicine. Oleiros (La Coruña): Netbiblo.
    In this paper, I offer one example of conceptual change. Specifically, I contend that the discovery that viruses could cause cancer represents an excellent example of branch jumping, one of Thagard’s nine forms of conceptual change. Prior to about 1960, cancer was generally regarded as a degenerative, chronic, non-infectious disease. Cancer causation was therefore usually held to be a gradual process of accumulating cellular damage, caused by relatively non-specific component causes, acting over long periods of time. Viral infections, on the (...)
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  6.  15
    Mapping the methodologies of Burkitt lymphoma.Brendan Clarke - 2014 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 48:210-217.
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  7. Discovery in medicine.Brendan Clarke - 2016 - In Miriam Solomon, Jeremy R. Simon & Harold Kincaid (eds.), The Routledge Companion to Philosophy of Medicine. Routledge.
     
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  8. Causation and melanoma classification.Brendan Clarke - 2011 - Theoretical Medicine and Bioethics 32 (1):19-32.
    In this article, I begin by giving a brief history of melanoma causation. I then discuss the current manner in which malignant melanoma is classified. In general, these systems of classification do not take account of the manner of tumour causation. Instead, they are based on phenomenological features of the tumour, such as size, spread, and morphology. I go on to suggest that misclassification of melanoma is a major problem in clinical practice. I therefore outline an alternative means of classifying (...)
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  9.  17
    Sampling philosophy of medicine: Philippe Huneman, Gérard Lambert and Marc Silberstein : Classification, disease and evidence: new essays in the philosophy of medicine. Dordrecht, Heidelberg, New York, London: Springer, 2015, 232pp, $129 HB.Brendan Clarke - 2015 - Metascience 25 (1):87-90.
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  10.  24
    Response to Open Peer Commentaries on “A Radical Approach to Ebola: Saving Humans and Other Animals”.Carolyn P. Neuhaus, Brendan Clarke, Phyllis Illari, Charles H. Norell & Sarah J. L. Edwards - 2019 - American Journal of Bioethics 19 (1):W8-W9.
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  11.  26
    Making sense of failure. [REVIEW]Brendan Clarke - 2014 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 48:122-125.
    Essay review of C. Timmermann A history of lung cancer: The recalcitrant disease (Palgrave Macmillan, Basingstoke (2014)) and C. Timmermann, E. Toon (Eds.), Cancer patients, cancer pathways: historical and social perspectives (Palgrave Macmillan, Basingstoke (2012)).
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  12.  22
    First page preview.Jonathan Bain, Timothy Bays, Katherine A. Brading, Stephen G. Brush, Murray Clarke, Sharyn Clough, Jonathan Cohen, Giancarlo Ghirardi, Brendan S. Gillon & Robert G. Hudson - 2004 - International Studies in the Philosophy of Science 18 (2-3).
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  13.  87
    Evaluating evidence of mechanisms in medicine.Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly, Charles Norell, Federica Russo, Beth Shaw & Jon Williamson - 2018 - Dordrecht, Netherlands: Springer. Edited by Brendan Clarke, Phyllis Illari, Michael P. Kelly, Charles Norell, Federica Russo, Beth Shaw, Christian Wallmann, Michael Wilde & Jon Williamson.
    The use of evidence in medicine is something we should continuously seek to improve. This book seeks to develop our understanding of evidence of mechanism in evaluating evidence in medicine, public health, and social care; and also offers tools to help implement improved assessment of evidence of mechanism in practice. In this way, the book offers a bridge between more theoretical and conceptual insights and worries about evidence of mechanism and practical means to fit the results into evidence assessment procedures.
  14.  22
    Learning to Expect: Predicting Sounds During Movement Is Related to Sensorimotor Association During Listening.Jed D. Burgess, Brendan P. Major, Claire McNeel, Gillian M. Clark, Jarrad A. G. Lum & Peter G. Enticott - 2019 - Frontiers in Human Neuroscience 13.
  15.  42
    A Radical Approach to Ebola: Saving Humans and Other Animals.Sarah J. L. Edwards, Charles H. Norell, Phyllis Illari, Brendan Clarke & Carolyn P. Neuhaus - 2018 - American Journal of Bioethics 18 (10):35-42.
    As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such trials will continue to face significant practical, philosophical, and ethical challenges. This article argues that researchers should also test the safety and effectiveness of novel vaccines in wild apes by employing a pluralistic approach to evidence. There are three reasons to (...)
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  16. Metabolic theories of Whipple disease.Oscar Morice, Mathew Elameer, Mina Arsanious, Helen Stephens, Eleanor Soutter, Thomas Hughes & Brendan Clarke - manuscript
    Whipple disease is a rare, infectious, disease first described from a single case by Whipple in 1907. As well as characterising the clinical and pathological features of the condition, Whipple made two suggestions regarding its aetiology. These were either than the disease was caused by an infectious agent, or that it was of metabolic origin. As the disease is now thought to be caused by infection with the bacterium Tropheryma whipplei, historical reviews of the history of the disease typically mention (...)
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  17.  17
    The God Who Is Beauty: Beauty as a Divine Name in Thomas Aquinas and Dionysius the Areopagite. By Brendan Thomas Sammon. Pp. ix, 391, Cambridge, James Clarke, 2014, $44.00. [REVIEW]Patrick Madigan - 2016 - Heythrop Journal 57 (2):371-372.
  18. Moral psychology as accountability.Brendan Dill & Stephen Darwall - 2014 - In Justin D'Arms & Daniel Jacobson (eds.), Moral Psychology and Human Agency: Philosophical Essays on the Science of Ethics. Oxford University Press UK. pp. 40-83.
    Recent work in moral philosophy has emphasized the foundational role played by interpersonal accountability in the analysis of moral concepts such as moral right and wrong, moral obligation and duty, blameworthiness, and moral responsibility (Darwall 2006; 2013a; 2013b). Extending this framework to the field of moral psychology, we hypothesize that our moral attitudes, emotions, and motives are also best understood as based in accountability. Drawing on a large body of empirical evidence, we argue that the implicit aim of the central (...)
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  19. The excellent 11: an award-winning teacher's guide to motivate, inspire, and educate kids.Ron Clark - 2023 - New York: Hachette.
    From the Disney 'Teacher of the Year' and New York Times bestselling author comes a road map to enrich students' learning experiences, revised and updated for today's teachers and parents. After publishing the New York Times bestseller The Essential 55 (over 1 million copies sold), award-winning teacher Ron Clark took his rules on the road and traveled to schools and districts in 50 states. He met amazing teachers, administrators, students, parents, and all kinds of people involved in bringing up great (...)
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  20.  29
    Moral imagination: Facilitating prosocial decision-making through scene imagery and theory of mind.Brendan Gaesser, Kerri Keeler & Liane Young - 2018 - Cognition 171 (C):180-193.
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  21.  14
    Episodic mindreading: Mentalizing guided by scene construction of imagined and remembered events.Brendan Gaesser - 2020 - Cognition 203 (C):104325.
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  22.  10
    Burt uses a fallacious motte-and-bailey argument to dispute the value of genetics for social science.Brendan P. Zietsch, Abdel Abdellaoui & Karin J. H. Verweij - 2023 - Behavioral and Brain Sciences 46:e231.
    Burt's argument relies on a motte-and-bailey fallacy. Burt aims to argue against the value of genetics for social science; instead she argues against certain interpretations of a specific kind of genetics tool, polygenic scores (PGSs). The limitations, previously identified by behavioural geneticists including ourselves, do not negate the value of PGSs, let alone genetics in general, for social science.
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  23. The Wrong Thinking in Conspiracy Theories.Brendan Shea - 2019 - In Conspiracy Theories: Philosophers Connect the Dots. Chicago: Open Court. pp. 193-203.
    Political conspiracy theories—e.g., unsupported beliefs about the nefarious machinations of one’s cunning, powerful, and evil opponents—are adopted enthusiastically by a great many people of widely varying political orientations. In many cases, these theories posit that there exists a small group of individuals who have intentionally but secretly acted to cause economic problems, political strife, and even natural disasters. This group is often held to exist “in the shadows,” either because its membership is unknown, or because “the real nature” of its (...)
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  24. Palgrave Handbook of Popular Culture as Philosophy.Brendan Shea (ed.) - 2021 - Springer.
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  25. House of Cards as Philosophy: Democracy on Trial.Brendan Shea - 2021 - In Palgrave Handbook of Popular Culture as Philosophy. Springer.
    Over the course of its six seasons, the Netflix show the House of Cards (HOC) details the rise to power of Claire and Frank Underwood in a fictional United States. They achieve power not by winning free and fair elections, but by exploiting various weaknesses of the U.S. political system. Could such a thing happen to our own democracies? This chapter argues that it is a threat that should be taken seriously, as the structure of HOC’s democratic institutions closely mirrors (...)
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  26.  35
    Attentional Bias for Threatening Facial Expressions in Anxiety: Manipulation of Stimulus Duration.Brendan P. Bradley, Karin Mogg, Sara J. Falla & Lucy R. Hamilton - 1998 - Cognition and Emotion 12 (6):737-753.
  27.  64
    Philosophy in Classical India: The Proper Work of Reason.Brendan S. Gillon - 2003 - Mind 112 (448):707-711.
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  28. Ambiguity, indeterminacy, deixis and vagueness: Evidence and theory.Brendan S. Gillon - 2004 - In Steven Davis & Brendan S. Gillon (eds.), Semantics: a reader. New York: Oxford University Press. pp. 157--190.
     
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  29.  61
    Against the perceptual model of utterance comprehension.Brendan Balcerak Jackson - 2019 - Philosophical Studies 176 (2):387-405.
    What accounts for the capacity of ordinary speakers to comprehend utterances of their language? The phenomenology of hearing speech in one’s own language makes it tempting to many epistemologists to look to perception for an answer to this question. That is, just as a visual experience as of a red square is often taken to give the perceiver immediate justification for believing that there is a red square in front of her, perhaps an auditory experience as of the speaker asserting (...)
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  30. Debunking and Dispensability.Justin Clarke-Doane - 2016 - In Uri D. Leibowitz & Neil Sinclair (eds.), Explanation in Ethics and Mathematics: Debunking and Dispensability. Oxford, England: Oxford University Press UK.
    In his précis of a recent book, Richard Joyce writes, “My contention…is that…any epistemological benefit-of-the-doubt that might have been extended to moral beliefs…will be neutralized by the availability of an empirically confirmed moral genealogy that nowhere…presupposes their truth.” Such reasoning – falling under the heading “Genealogical Debunking Arguments” – is now commonplace. But how might “the availability of an empirically confirmed moral genealogy that nowhere… presupposes” the truth of our moral beliefs “neutralize” whatever “epistemological benefit-of-the-doubt that might have been extended (...)
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  31. Promises as Proposals in Joint Practical Deliberation.Brendan Kenessey - 2020 - Noûs 54 (1):204-232.
    This paper argues that promises are proposals in joint practical deliberation, the activity of deciding together what to do. More precisely: to promise to ϕ is to propose (in a particular way) to decide together with your addressee(s) that you will ϕ. I defend this deliberative theory by showing that the activity of joint practical deliberation naturally gives rise to a speech act with exactly the same properties as promises. A certain kind of proposal to make a joint decision regarding (...)
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  32.  12
    Brain imaging in clinical psychiatry : why?Brendan D. Kelly - 2012 - In Sarah Richmond, Geraint Rees & Sarah J. L. Edwards (eds.), I know what you're thinking: brain imaging and mental privacy. Oxford: Oxford University Press. pp. 111.
  33. A Little More Logical: Reasoning Well About Science, Ethics, Religion, and the Rest of Life.Brendan Shea - 2023 - Rochester, MN: Thoughtful Noodle Books.
    "A Little More Logical" is the perfect guide for anyone looking to improve their critical thinking and logical reasoning skills. With chapters on everything from logic basics to fallacies of weak induction to moral reasoning, this book covers all the essential concepts you need to become a more logical thinker. You'll learn about influential figures in the field of logic, such as Rudolph Carnap, Betrrand Russell, and Ada Lovelace, and how to apply your newfound knowledge to real-world situations. Whether you're (...)
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  34. House of Cards as Philosophy: Democracy on Trial.Brendan Shea - 2022 - In David Kyle Johnson (ed.), The Palgrave Handbook of Popular Culture as Philosophy. Palgrave-Macmillan. pp. 361-382.
    Over the course of its six seasons, the Netflix show House of Cards (HOC) details the rise to power of Claire and Frank Underwood in a fictional United States. They achieve power not by winning free and fair elections, but by exploiting various weaknesses of the US political system. Could such a thing happen to our own democracies? This chapter argues that it is a threat that should be taken seriously, as the structure of HOC’s democratic institutions closely mirrors our (...)
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  35.  28
    Covert and overt orienting of attention to emotional faces in anxiety.Brendan P. Bradley, Karin Mogg & Neil H. Millar - 2000 - Cognition and Emotion 14 (6):789-808.
  36. Against deliberative indispensability as an independent guide to what there is.Brendan Cline - 2016 - Philosophical Studies 173 (12):3235-3254.
    David Enoch has recently proposed that the deliberative indispensability of irreducibly normative facts suffices to support their inclusion in our ontology, even if they are not necessary for the explanation of any observable phenomena. He challenges dissenters to point to a relevant asymmetry between explanation and deliberation that shows why explanatory indispensability, but not deliberative indispensability, is a legitimate guide to ontology. In this paper, I aim to do just that. Given that an entity figures in the actual explanation of (...)
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  37. Nativism and the Evolutionary Debunking of Morality.Brendan Cline - 2015 - Review of Philosophy and Psychology 6 (2):231-253.
    Evolutionary debunking arguments purport to undercut the justification of our moral judgments by showing why a tendency to make moral judgments would evolve regardless of the truth of those judgments. Machery and Mallon (2010. Evolution of morality. In J.M. Doris and The Moral Psychology Research Group (Eds.), The Moral Psychology Handbook (pp. 3-46). Oxford: Oxford University Press) have recently tried to disarm these arguments by showing that moral cognition – in the sense that is relevant to debunking – is not (...)
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  38. Nietzsche and moral objectivity : the development of Nietzsche's metaethics.Maudemarie Clark & David Dudrick - 2007 - In Brian Leiter & Neil Sinhababu (eds.), Nietzsche and morality. New York: Oxford University Press. pp. 192--226.
  39. What is an omission?Randolph Clarke - 2012 - Philosophical Issues 22 (1):127-143.
    This paper examines three views of what an omission or an instance of refraining is. The view advanced is that in many cases, an omission is simply an absence of an action of some type. However, generally one’s not doing a certain thing counts as an omission only if there is some norm, standard, or ideal that calls for one’s doing that thing.
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  40.  18
    Resolving the evolutionary paradox of consciousness.Brendan P. Zietsch - forthcoming - Phenomenology and the Cognitive Sciences:1-19.
    Evolutionary fitness threats and rewards are associated with subjectively unpleasant and pleasant sensations, respectively. Initially, these correlations appear explainable via adaptation by natural selection. But here I analyse the major metaphysical perspectives on consciousness – physicalism, dualism, and panpsychism – and conclude that none help to understand the adaptive-seeming correlations via adaptation. I also argue that a recently proposed explanation, the phenomenal powers view, has major problems that mean it cannot explain the adaptive-seeming correlations via adaptation either. So the mystery (...)
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  41.  29
    Designing Species.Brendan Cline - 2023 - Ethics and the Environment 28 (2):43-80.
    Abstract:Should we use modern bioengineering techniques to design species? An instrumentalist account of species’ value offers permissive guidance. But what if species exemplify final value? Is it always very good to create new species? Is it always very wrong to blend or modify existing species? In this paper, I argue that both extremes are implausible. However, final value theories struggle to deliver a flexible, moderate treatment of these issues, and so the ethics of designing species presents a challenge for final (...)
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  42.  15
    Emotion as a Student Resource in Higher Education.Brendan Bartram - 2015 - British Journal of Educational Studies 63 (1):67-84.
  43.  43
    Some hazards of motivational internalism: the practical case for externalism.Brendan Cline - forthcoming - Inquiry: An Interdisciplinary Journal of Philosophy.
    Internalists and externalists disagree over how intimately normative judgment and motivation are linked. Proponents on both sides typically try to settle the issue by descriptively interpreting our concept of a normative judgment. Unfortunately, this approach has resulted in deep and apparently intractable disagreement. It is time to consider alternative strategies. In this paper, I argue that the internalist/externalist debate is particularly ripe for revisionary arguments that evaluate conceptions of normative judgment in light of the costs and benefits of their adoption. (...)
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  44. Verbal Disputes and Substantiveness.Brendan Balcerak Jackson - 2014 - Erkenntnis 79 (S1):31-54.
    One way to challenge the substantiveness of a particular philosophical issue is to argue that those who debate the issue are engaged in a merely verbal dispute. For example, it has been maintained that the apparent disagreement over the mind/brain identity thesis is a merely verbal dispute, and thus that there is no substantive question of whether or not mental properties are identical to neurological properties. The goal of this paper is to help clarify the relationship between mere verbalness and (...)
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  45.  99
    Hormone Treatment of Children and Adolescents with Gender Dysphoria: An Ethical Analysis.Brendan S. Abel - 2014 - Hastings Center Report 44 (s4):23-27.
    In the context of transgender health, most people are not comfortable with allowing a twelve‐year‐old child with gender dysphoria to elect to undergo gender reassignment surgery. The likelihood is too high that the child would be unable to fully comprehend the scope of a decision that carries significant, permanent consequences, particularly because the decision to surgically change gender is based upon a conception of gender that can fluctuate during adolescent years. Conversely, however, most people would not contend that this fluidity (...)
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  46. Perceptual Inference Through Global Lexical Similarity.Brendan T. Johns & Michael N. Jones - 2012 - Topics in Cognitive Science 4 (1):103-120.
    The literature contains a disconnect between accounts of how humans learn lexical semantic representations for words. Theories generally propose that lexical semantics are learned either through perceptual experience or through exposure to regularities in language. We propose here a model to integrate these two information sources. Specifically, the model uses the global structure of memory to exploit the redundancy between language and perception in order to generate inferred perceptual representations for words with which the model has no perceptual experience. We (...)
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  47. Moral Explanations, Thick and Thin.Brendan Cline - 2015 - Journal of Ethics and Social Philosophy 9 (2):1-20.
    Cornell realists maintain that irreducible moral properties have earned a place in our ontology in virtue of the indispensable role they play in a variety of explanations. These explanations can be divided into two groups: those that employ thin ethical concepts and those that employ thick ethical concepts. Recent work on thick concepts suggests that they are not inherently evaluative in their meaning. If correct, this creates problems for the moral explanations of Cornell realists, since the most persuasive moral explanations (...)
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  48. Delusional thinking and perceptual disorder.Brendan A. Maher - 1974 - Journal of Individual Psychology 30 (1):98-113.
     
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  49.  75
    Smith’s practicality requirement meets dual-process models of moral judgment.Brendan Cline - 2017 - Philosophical Psychology 30 (8):1043-1063.
    In The Moral Problem, Michael Smith argues that only motivational internalists can offer an adequate explanation of why changes in moral judgment tend to be accompanied by changes in motivation in morally virtuous people. Smith argues that the failure of motivational externalism to account for this phenomenon amounts to a reductio of the view. In this paper, I draw on dual-process models of moral judgment to develop an externalist response to Smith’s argument. The key to my proposal is that motivationally (...)
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  50.  21
    Disentangling contextual diversity: Communicative need as a lexical organizer.Brendan T. Johns - 2021 - Psychological Review 128 (3):525-557.
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