This review explores the hypothesis that regulation of nucleocytoplasmic shuttling is a means of driving differentiation, using spermatogenesis as a model. The transition from undifferentiated spermatogonial stem cell to terminally differentiated spermatozoon is, at its most basic, a change in the repertoire of expressed genes. To effect this, the complement of nuclear proteins, such as transcription factors and chromatin remodelling components must change. Current knowledge of the nuclear proteins and nucleocytoplasmic transport machinery relevant to spermatogenesis is consolidated in this review, (...) and their functional linkages are highlighted not only as a means of regulating nuclear protein composition, but also as a key mechanism regulating gene transcription and hence cell fate. Through this, we hypothesize that male germ cell differentiation is mediated through regulation of nuclear transport machinery components, and thereby of the access of critical factors to the nucleus. The importance of nucleocytoplasmic trafficking to male germ cell differentiation is discussed, using the sex-determining factors Sry and SOX9, cell cycle regulators, CREM and cofactors and the Smads as specific examples, together with the roles in gametogenesis for particular nuclear transport factors in Caenorhabditis elegans and Drosophila. BioEssays 27:1011–1025, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

A judgement analysis of people's social inferences of attitudes and ability was conducted. University students were asked to infer the liberalness ( N = 60; Study 1) or intelligence ( N = 40; Study 2) of targets seen in pictures. Multiple regression analyses revealed that attractiveness was the most important cue for predicting inferences of liberalness, while an ethnic cue (i.e., being Asian) was the most important cue for judgements about intelligence. Results also showed that a single-cue model was less (...) susceptible to overfitting, but significantly less accurate than a multiple-cue model in predicting participant's intelligence judgements. Although the multiple regression models suffered a degree of overfitting, cross validation showed that they continued to have significant predictive value when applied to new data. Furthermore, a “random partner” method (comparing each participant's own regression equation with that of another, randomly selected, participant) provided evidence of significant idiosyncratic variation in the way intelligence judgements were made. (shrink)

Light has often been privileged as a metaphor for objectivity and truth in Western thought, a status that has been challenged by recent feminist thought as giving entitlement to the masculine. This book presents a compelling new perspective on this metaphor, and explores the role the visual plays in Western philosophy by examining the thought of Irigaray, Levinas and Merleau- Ponty. Textures of Light is one of the first studies to challenge current interpretations by presenting Irigaray as a philosopher of (...) vision rather than touch. (shrink)

I am proposing that when engaging with the narrative of another, there needs to be a conscious consideration, an essential articulation of enquiry; a pause.

In this paper I argue that a newborn child and the Mother, defined as any person who takes up the role of other,1 reflect the ontological connectedness of God and humankind. The relationship between the infant and other is experienced by the child as if the two are one, and in this, life is first experienced by the infant as being ‘not alone’. The human interactions that we experience, or do not in early infancy, have such a profound psychological effect (...) on us that we continue to be impacted by them for our whole lives and to this end I assert that the experience of at-one-ness I will write about, fundamentally establishes the experience of the infant in the context of God, self and the other. (shrink)

: In this article, Bailey analyzes the relationship between ethical vegetarianism (or the claim that ethical vegetarianism is morally right for all people) and white racism (the claim that white solipsistic and possibly white privileged ethical claims are imperialistically or insensitively universalized over less privileged human lives). This plays out in the dreaded comparison of animals with people of color and Jews as exemplified in the PETA campaign and the need for human identification (or solidarity) with animals in ethical vegetarianism. (...) To support the viability of ethical vegetarianism, Bailey resolves the dread of this comparison by locating ethical vegetarianism as a strategy of resistance to classist, racist, heterosexist, and colonialist systems of power that often rely on the assumptions of speciesism to ground these axes of oppression. The author carries out this argument to contextualize African American responses to animal welfarism and ethical vegetarianism. (shrink)

In this article, Bailey analyzes the relationship between ethical vegetarianism and white racism. This plays out in the dreaded comparison of animals with people of color and Jews as exemplified in the PETA campaign and the need for human identification with animals in ethical vegetarianism. To support the viability of ethical vegetarianism, Bailey resolves the dread of this comparison by locating ethical vegetarianism as a strategy of resistance to classist, racist, heterosexist, and colonialist systems of power that often rely on (...) the assumptions of speciesism to ground these axes of oppression. The author carries out this argument to contextualize African American responses to animal welfarism and ethical vegetarianism. (shrink)

Despite the fact that feminists have compellingly drawn connections between traditional notions of reason and the oppression of women and nature, many animal ethicists fail to deeply incorporate these insights. After detailing the links between reason and the oppression of women and animals, I argue that the work of philosophers such as Tom Regan and Peter Singer fails to reflect that what feminists have called is not the mere inclusion of emotion, but a recognition of the inherent continuity between the (...) two. To ignore this continuity, I conclude, risks reinscribing the very suffering we seek to eliminate. (shrink)

In this article, Bailey analyzes the relationship between ethical vegetarianism and white racism. This plays out in the dreaded comparison of animals with people of color and Jews as exemplified in the PETA campaign and the need for human identification with animals in ethical vegetarianism. To support the viability of ethical vegetarianism, Bailey resolves the dread of this comparison by locating ethical vegetarianism as a strategy of resistance to classist, racist, heterosexist, and colonialist systems of power that often rely on (...) the assumptions of speciesism to ground these axes of oppression. The author carries out this argument to contextualize African American responses to animal welfarism and ethical vegetarianism. (shrink)

In his recent article On Relativity Theory and Openness of the Future (1991), Howard Stein proves not only that one can define an objective becoming relation in Minkowski spacetime, but that there is only one possible definition available if one accepts certain natural assumptions about what it is for becoming to occur and for it to be objective. Stein uses the definition supplied by his proof to refute an argument due to Rietdijk (1966, 1976), Putnam (1967) and Maxwell (1985, 1988) (...) that Minkowski spacetime leaves no room for objective becoming whatsoever. However, Stein's proof does not seem to go far enough. By considering only what events have become from the standpoint of any given event, Stein's uniqueness proof fails from the outset to allow for a more general kind of becoming whereby it is understood to occur from the standpoint of events on the particular worldlines followed by observers. This suggests that there may, after all, be more than one way to define objective becoming in Minkowski spacetime once each observer's worldline is allowed to figure in the definition. This suspicion is further aroused by two recent proposals for objective, worldline-dependent becoming due to Peacock (1992) and Muller (1992) who advocate ways of defining becoming that are not equivalent to the definition Stein's uniqueness proof delivers. Nevertheless, we show that Stein's uniqueness proofcan be extended in a natural way to cover this more general kind of becoming, provided one does not enrich standard Minkowski spacetime by privileging certain sets of worldlines over others in an unwarranted manner. Thus we aim to reinforce Stein's point that standard Minkowski spacetime does make room for objective becoming, but in essentially only one way, despite arguments and proposals to the contrary. (shrink)

A true Turing machine requires an infinitely long paper tape. Thus a TM can be housed in the infinite world of Newtonian spacetime, but not necessarily in our world, because our world-at least according to our best spacetime theory, general relativity-may be finite. All the same, one can argue for the "existence" of a TM on the basis that there is no such housing problem in some other relativistic worlds that are similar to our world. But curiously enough-and this is (...) the main point of this paper-some of these close worlds have a special spacetime structure that allows TMs to perform certain Turing unsolvable tasks. For example, in one kind of spacetime a TM can be used to solve first-order predicate logic and the halting problem. And in a more complicated spacetime, TMs can be used to decide arithmetic. These new computers serve to show that Church's thesis is a thoroughly contingent claim. Moreover, since these new computers share the fundamental properties of a TM in ordinary operation, a computability theory based on these non-Turing computers is no less worthy of investigation than orthodox computability theory. Some ideas about this new mathematical theory are given. (shrink)

: Despite the fact that feminists have compellingly drawn connections between traditional notions of reason and the oppression of women and nature, many animal ethicists fail to deeply incorporate these insights. After detailing the links between reason and the oppression of women and animals, I argue that the work of philosophers such as Tom Regan and Peter Singer fails to reflect that what feminists have called is not the mere inclusion of emotion, but a recognition of the inherent continuity between (...) the two. To ignore this continuity, I conclude, risks reinscribing the very suffering we seek to eliminate. (shrink)

A true Turing machine (TM) requires an infinitely long paper tape. Thus a TM can be housed in the infinite world of Newtonian spacetime (the spacetime of common sense), but not necessarily in our world, because our world-at least according to our best spacetime theory, general relativity-may be finite. All the same, one can argue for the "existence" of a TM on the basis that there is no such housing problem in some other relativistic worlds that are similar ("close") to (...) our world. But curiously enough-and this is the main point of this paper-some of these close worlds have a special spacetime structure that allows TMs to perform certain Turing unsolvable tasks. For example, in one kind of spacetime a TM can be used to solve first-order predicate logic and the halting problem. And in a more complicated spacetime, TMs can be used to decide arithmetic. These new computers serve to show that Church's thesis is a thoroughly contingent claim. Moreover, since these new computers share the fundamental properties of a TM in ordinary operation (e.g. intuitive, finitely programmed, limited in computational capability), a computability theory based on these non-Turing computers is no less worthy of investigation than orthodox computability theory. Some ideas about this new mathematical theory are given. (shrink)

Beyond Weimar Culture – The Significance of the Forman Thesis for a Cultural Approach to the History of Science. The famous ‘Forman thesis’, published in 1971, argued for a historical linkage among the intellectual atmosphere of Weimar Germany, popular revolts against determinism and materialism, and the creation of the revolutionary new theory of quantum mechanics. Paul Forman's long essay on “Weimar Culture” has shaped research agendas in numerous fields, from the history and philosophy of physics to German history to the (...) sociology of scientific knowledge. Despite its status as a classic and its transformative effect, Weimar Culture has always inspired as much critique as assent. In particular in the history of science, cohorts of students and two generations of scholars have debated the Forman thesis as a conceptual tool for linking scientific change with cultural processes. The Forman thesis raises critical questions for both the ongoing debates over cultural approaches to the history of science and the burgeoning newer scholarship on physics in and beyond Weimar Germany. Exploring these implications has been the aim of a transnational project of the three authors of this article which sheds some light on these debates and briefly introduces the following papers of this special issue devoted to Paul Forman and his seminal works in the history of science. (shrink)

Drawing on the work of Irigaray and Levinas, this paper discusses the ethical limitations of Lacan's "mirror-stage" dynamic and interpolates a different interpretation of the material he uses to elaborate his theory. Close attention is paid to the significance of metaphors of vision and touch in the work of the three philosophers. The paper develops into an analysis of Irigaray's and Levinas's interpretations of touch as the differential site of ethics.

Benjamin Wurgaft 'How Heavy Light Can Be' _Film-Philosophy_, vol. 6 no. 9, May 2002 Joshua Shaw 'Struggling to See the Light' _Film-Philosophy_, vol. 6 no. 10, May 2002.

Presented here is a new result concerning the computational power of so-called SADn computers, a class of Turing-machine-based computers that can perform some non-Turing computable feats by utilising the geometry of a particular kind of general relativistic spacetime. It is shown that SADn can decide n-quantifier arithmetic but not (n+1)-quantifier arithmetic, a result that reveals how neatly the SADn family maps into the Kleene arithmetical hierarchy. Introduction Axiomatising computers The power of SAD computers Remarks regarding the concept of computability.

If there actually is a third wave of feminism, it is too close to the second wave for its definition to be clear and uncontroversial, a fact which emphasizes the political nature of declaring the existence of this third wave. Through an examination of some third wave literature, a case is made for emphasizing the continuity of the second and third waves without blurring the differences between older and younger feminists.

: The achievements of Anna Julia Cooper are extraordinary given her life circumstances. Driven by a desire Cooper called "a thumping within," she became a prominent educator, earned her Ph.D., and influenced the thought of W.E.B. DuBois and others. Cooper fought for her educational philosophy, but despite her contributions, her apparent elitism has shaped contemporary assessments of her work. I argue that her views must be considered in social and historical context.

: The long history of criticism directed at bullfighting usually suggests that there is something especially morally noxious about it. I analyze the claims that bullfighting is distinctively immoral, comparing it to more widely accepted practices such as the slaughtering of animals for food. I conclude that, while bullfighting is horrific, the emphasis on it as especially "uncivilized" may serve to disguise the similarities that it has with other practices that also depend on animal suffering. I conclude that, for many, (...) the hypocritical maintenance of a self-image as "civilized," despite great moral crimes committed against animals, seems to be facilitated by a focus on this especially dramatic example of animal cruelty. (shrink)

The achievements of Anna Julia Cooper are extraordinary given her life circumstances. Driven by a desire Cooper called "a thumping within," she became a prominent educator, earned her Ph.D., and influenced the thought of W.E.B. DuBois and others. Cooper fought for her educational philosophy, but despite her contributions, her apparent elitism has shaped contemporary assessments of her work. I argue that her views must be considered in social and historical context.

The achievements of Anna Julia Cooper are extraordinary given her life circumstances. Driven by a desire Cooper called "a thumping within," she became a prominent educator, earned her Ph.D., and influenced the thought of W.E.B. DuBois and others. Cooper fought for her educational philosophy, but despite her contributions, her apparent elitism has shaped contemporary assessments of her work. I argue that her views must be considered in social and historical context.

In discussions of animal ethics, hypothetical scenarios are often used to try to force the clarification of intuitions about the relative value of human and animal life. Tom Regan requests, for example, that we imagine a man and a dog adrift in a lifeboat while Peter Singer explains why the life of one's child ought to be preferred to that of the family dog in the event of a house fire. I argue that such scenarios are not the usefully abstract (...) analytic tools they purport to be, but indirectly reinforce assumptions that are not only anthropocentric, but also tied to racist, sexist and ethnocentric stereotypes. An analysis of some of the cultural and ethical associations of the notion of self-sacrifice proves especially useful in revealing some of the limitations of certain popular Western approaches to animal ethics. (shrink)

I explore how the Buddhist icon Kuan Yin is emerging as a point of identification for trans people and has the potential to resolve a tension within feminism. As a figure that slips past the male/female binary, Kuan Yin explodes the dichotomy between universal and particular in a way that captures the pragmatist and feminist emphasis on doing justice to concrete, particular lives without becoming stuck in an essentialist quagmire.

This study examines the role of corporate philanthropy in the management of reputation risk and shareholder value of the top 100 ASX listed Australian firms for the 3 years 2011–2013. The results of this study demonstrate the business case for corporate philanthropy and hence encourage corporate philanthropy by showing increasing firms’ investment in corporate giving as a percentage of profit before tax, increases the likelihood of an increase in shareholder value. However, the proviso is that firms must also manage their (...) reputation risk at the same time. There is a negative association between corporate giving and shareholder value which is mitigated by firms’ management of reputation. The economic significance of this result is that for every cent in the dollar the firm spends on corporate giving, Tobin’s Q will decrease by 0.413 %. In contrast, if the firm increase their reputation by 1 point then Tobin’s Q will increase by 0.267 %. Consequently, the interaction of corporate giving and reputation risk management is positively associated with shareholder value. These results are robust while controlling for potential endogeneity and reverse causality. This paper assists both academics and practitioners by demonstrating that the benefits of corporate philanthropy extend beyond a gesture to improve reputation or an attempt to increase financial performance, to a direct collaboration between all the factors where the benefits far outweigh the costs. (shrink)

The effectiveness of decision rules depends on characteristics of both rules and environments. A theoretical analysis of environments specifies the relative predictive accuracies of the “take-the-best” heuristic (TTB) and other simple strategies for choices between two outcomes based on binary cues. We identify three factors: how cues are weighted; characteristics of choice sets; and error. In the absence of error and for cases involving from three to five binary cues, TTB is effective across many environments. However, hybrids of equal weights (...) (EW) and TTB models are more effective as environments become more compensatory. As error in the environment increases, the predictive ability of all models is systematically degraded. Indeed, using the datasets of Gigerenzer et al. (1999, Simple Heuristics That Make Us Smart, New York: Oxford University Press), TTB and similar models do not predict much better than a naïve model that exploits dominance. Finally, we emphasize that the results reported here are conditional on binary cues. (shrink)

ArgumentObjectivity has been constitutive of the modern scientific persona. Its significance has depended on its excision of standpoint, which has legitimated the scientist epistemically and sociopolitically at once. But if the nineteenth century reinforced those paired effects, the twentieth century brought questioning of both. The figure of Werner Heisenberg puts the latter process on display. From the Kaiserreich to the Federal Republic of Germany, between quantum mechanics and interest group politics, his evolution shows an increasing openness to perspectival pluralism, together (...) with an attempt to save some form of objectivity as discursive coherence. Heisenberg’s self-understanding and the reactions of his publics display the transmutation of the persona as objectivity was rethought. By the end of the day, speaking “as a scientist” would mean something different from what it had at the start. (shrink)

Moral distress is a common phenomenon among nurses and is related to the complicated work environments and complex nature of ethical situations in day-to-day nursing practice. Moral distress impacts nurses as well as patient care and the health care system. Few strategies have been identified for instructors to effectively engage with learners when communicating about moral distress. We discuss two key curricular and pedagogical strategies that should be utilized when learning about moral distress: difficult knowledge’ and ‘terror management theory’. Whether (...) it is with new nursing students or experienced nurses, there is necessary learning that needs to occur on moral distress. Difficult knowledge’ and ‘terror management theory’, when implemented, can provide a starting point for both the learner and the instructor to discuss the emotionally difficult and complex topic of moral distress. Knowledge about moral distress has the potential to mitigate its negative effects, therefore it is vital to consider educational strategies to teach nurses about this complex phenomenon. (shrink)