I. EXECUTIVE SUMMARY The MRCT Center Post-trial Responsibilities: Continued Access to an Investigational Medicine Framework outlines a case-based, principled, stakeholder approach to evaluate and guide ethical responsibilities to provide continued access to an investigational medicine at the conclusion of a patient’s participation in a clinical trial. The Post-trial Responsibilities (PTR) Framework includes this Guidance Document as well as the accompanying Toolkit. A 41-member international multi-stakeholder Workgroup convened by the Multi-Regional Clinical Trials Center of Brigham and Women’s Hospital and Harvard University (...) (MRCT Center) developed this Guidance and Toolkit. Project Motivation A number of international organizations have discussed the responsibilities stakeholders have to provide continued access to investigational medicines. The World Medical Association, for example, addressed post-trial access to medicines in Paragraph 34 of the Declaration of Helsinki (WMA, 2013): “In advance of a clinical trial, sponsors, researchers and host country governments should make provisions for post-trial access for all participants who still need an intervention identified as beneficial in the trial. This information must also be disclosed to participants during the informed consent process.” This paragraph and other international guidance documents converge on several consensus points: • Post-trial access (hereafter referred to as “continued access” in this Framework [for terminology clarification – see definitions]) is the responsibility of sponsors, researchers, and host country governments; • The plan for continued access should be determined before the trial begins, and before any individual gives their informed consent; • The protocol should delineate continued access plans; and • The plan should be transparent to potential participants and explained during the informed consent process. -/- However, there is no guidance on how to fulfill these responsibilities (i.e., linking specific responsibilities with specific stakeholders, conditions, and duration). To fill this gap, the MRCT Center convened a working group in September of 2014 to develop a framework to guide stakeholders with identified responsibilities. This resultant Framework sets forth applicable principles, approaches, recommendations and ethical rationales for PTR regarding continued access to investigational medicines for research participants. (shrink)

In 1928, Friedrich Solmsen argued that Aristotle'sPosterior Analyticswas largely composed before thePrior Analytics. Ross rejected Solmsen's position in 1939, and a rather lengthy series of rebuttals and counter-attacks between the two scholars followed. Quite recently, Jonathan Barnes has revived this issue with arguments in favour of something very close to Solmsen's thesis: that Aristotle first developed a theory of demonstration (‘apodeictic’) before he had worked out the syllogistic, and that thePosterior Analyticswas originally conceived against this background. Subsequently, when Aristotle (...) formulated a syllogistic, he is supposed by Barnes to have revised or added to the contents of thePosterior Analyticsso as to make syllogistic the logic of Aristotelian science. Thus, Barnes says: ‘the syllogism is in fact an incidental adjunct to the theory of demonstration: the theory can be formulated without reference, explicit or implicit, to Syllogistic, and itcould havebeen discovered by someone who knew nothing whatever about the Syllogism’ (pp. 33–4). (shrink)

No interior do pensamento de Dewey, a gênese da estética merece mais atenção do que lhe é dada na literatura. Um aspecto, em especial, tem sido virtualmente negligenciado — com as notáveis exceções de Robins 2015, Ueno 2016, Hein 2017 e Granger 2018a e 2018b — a saber, os vínculos com Albert Coombs Barnes. Nossa hipótese é que Barnes desempenhou um papel relevante na “virada estética” da filosofia madura de Dewey. Neste artigo, nós tomamos um primeiro passo rumo (...) ao esclarecimento da relação entre eles e uma tentativa de mostrar a influência do colecionador de arte na obra do filósofo. (shrink)

WE must first state the subject of our inquiry and the faculty to which it belongs: its subject is demonstration and the faculty that carries it out demonstrative science.

Leading experts in the field contributing to this volume make the case for the singularity of thought and debate a broad spectrum of issues it raises, including ...

A full account of the philosophy of the Greek and Roman worlds from the last days of Aristotle until 100 BC. Hellenistic philosophy, for long relatively neglected and unappreciated, has over the last decade been the object of a considerable amount of scholarly attention. Now available in paperback, this 1999 volume is a general reference work which pulls the subject together and presents an overview. The History is organised by subject, rather than chronologically or by philosophical school, with sections on (...) logic, epistemology, physics and metaphysics, ethics and politics. It has been written by specialists but is intended to be a source of reference for any student of ancient philosophy, for students of classical antiquity and for students of the philosophy of later periods. Greek and Latin are used sparingly and always translated in the main text. (shrink)

Overview The debate over the semantics of proper names has, of late, heated up, focusing on the relative merits of referentialism and predicativism. Referentialists maintain that the semantic function of proper names is to designate individuals. They hold that a proper name, as it occurs in a sentence in a context of use, refers to a specific individual that is its referent and has just that individual as its semantic content, its contribution to the proposition expressed by the sentence. Furthermore, (...) a proper name contributes its referent to the proposition expressed by virtue of mechanisms of direct reference to individuals, not by virtue of expressing properties. Predicativists embrace an opposing view according to which proper names are just a special kind of common noun. Their semantic function is to designate properties of individuals. A proper name, as it occurs in a sentence in a context of use, expresses a property, and that property is its contribution to the proposition expr .. (shrink)

The reclamation of slurs raises a host of important questions. Some are linguistic: What are the linguistic conventions governing the slur post-reclamation and how are they related to the conventions governing it pre-reclamation? What mechanisms engender the shift? Others bend toward the social: Why do a slur’s targets have a special privilege in initiating its reclamation? Is there a systematic explanation why prohibitions on out-group use of reclaimed slurs vary from slur to slur? And how does reclamation contribute to shaping (...) social identities and reversing oppressive social norms and stigma? Most analyses of slur reclamation advance a single model to answer these questions. The author argues that there are different varieties of reclamation. Two predominate, what she calls pride reclamation and insular reclamation. While many features unite pride and insular reclamation, they differ with respect to the purpose of the reclamatory act, the linguistic mechanisms reclaimers employ to execute the linguistic change, and the social and grammatical roles of the reclaimed slur. By distinguishing these two types of reclamation and offering a fine-grained characterization of their properties, the author argues that we gain deeper insight into the reasons why slurs may in principle only be ignited by the target group and why pride- but not insular-reclaimed slurs become available for use by out-group members. (shrink)

Women, Modernism, and Performance is an interdisciplinary 2004 study that looks at a variety of texts and modes of performance in order to clarify the position of women within - and in relation to - modern theatre history. Considering drama, fiction and dance, as well as a range of performance events such as suffrage demonstrations, lectures, and legal trials, Penny Farfan expands on theatre historical narratives that note the centrality of female characters in male-authored modern plays but that do not (...) address the efforts of women artists to develop alternatives both to mainstream theatre practice and to the patriarchal avant garde. Focusing on Henrik Ibsen, Elizabeth Robins, Ellen Terry, Virginia Woolf, Djuna Barnes, Edith Craig, Radclyffe Hall and Isadora Duncan, Farfan identifies different objectives, strategies, possibilities and limitations of feminist-modernist performance practice and suggests how the artists in question transformed the representation of gender in art and life. (shrink)

As a class of terms and mental representations, proper names and mental names possess an important function that outstrips their semantic and psycho-semantic functions as common, rigid devices of direct reference and singular mental representations of their referents, respectively. They also function as abstract linguistic markers that signal and underscore their referents' individuality. I promote this thesis to explain why we give proper names to certain particulars, but not others; to account for the transfer of singular thought via communication with (...) proper names; and, more generally, to support a cognitivist, not acquaintance or instrumentalist, theory of singular thought. (shrink)

Donnellan famously argued that while one can fix the reference of a name with a definite description, one cannot thereby have a de re belief about the named object. All that is generated is meta-linguistic knowledge that the sentence “If there is a unique F, then N is F” is true. Donnellan’s argument and the sceptical position are extremely influential. This article aims to show that Donnellan’s argument is unsound, and that the Millian who embraces Donnellan’s scepticism that the reference-fixer (...) cannot secure the relevant de re belief faces a serious problem: Millianism about names plus scepticism about the reference-fixer’s de re belief conflicts with what seems to be an analytical thesis about the relationship between semantic content and understanding. The upshot is that the Millian has good reason to seek an alternative to scepticism. (shrink)

Controversy remains over exactly why Frege aimed to estabish logicism. In this essay, I argue that the most influential interpretations of Frege's motivations fall short because they misunderstand or neglect Frege's claims that axioms must be self-evident. I offer an interpretation of his appeals to self-evidence and attempt to show that they reveal a previously overlooked motivation for establishing logicism, one which has roots in the Euclidean rationalist tradition. More specifically, my view is that Frege had two notions of self-evidence. (...) One notion is that of a truth being foundationally secure, yet not grounded on any other truth. The second notion is that of a truth that requires only clearly grasping its content for rational, a priori justified recognition of its truth. The overarching thesis I develop is that Frege required that axioms be self-evident in both senses, and he relied on judging propositions to be self-evident as part of his fallibilist method for identifying a foundation of arithmetic. Consequently, we must recognize both notions in order to understand how Frege construes ultimate foundational proofs, his methodology for discovering and identifying such proofs, and why he thought the propositions of arithmetic required proof. (shrink)

Clarence Sloat, Ora Matushansky, and Delia Graff Fara advocate a Syntactic Rationale on behalf of predicativism, the view that names are predicates in all of their occurrences. Each argues that a set of surprising syntactic data compels us to recognize names as a special variety of count noun. This data set, they say, reveals that names’ interaction with the determiner system differs from that of common count nouns only with respect to the definite article ‘the’. They conclude that this special (...) distribution of names is best explained by the-predicativism, the view that posits the existence of the null-determiner ‘the’ preceding bare singular names. This essay argues that they have incorrectly discerned the syntactic facts: their critical data point concerning the ungrammaticality of sentences like “The Katherine wants coffee” is mistaken. Such sentences’ grammaticality undermines the Syntactic Rationale and presents serious auxiliary problems for predicativism. (shrink)

Theories of slurs aim to explain how – via semantics, pragmatics, or other mechanisms – speakers who use slurs convey that targets are inferior persons. I present two novel problems. The Slur Creation Problem: How do terms come to be slurs? An expression ‘e’ is introduced into the language. What are the mechanisms by which ‘e’ comes to possess properties distinctive of slurs? The Bigotry Formation Problem: Speakers’ uses of slurs are a prime mechanism of bigotry formation, not solely bigotry (...) perpetuation. With a use of a slur, how are speakers able to introduce new bigoted attitudes and actions toward targets? I argue that expressivism offers powerful resources to solve the problems. (shrink)

Names are referring expressions and interact with the determiner system only exceptionally, in stark contrast with count nouns. The-predicativists like Sloat, Matushansky, and Fara claim otherwise, maintaining that syntactic data offers indicates that names belong to a special syntactic category which differs from common count nouns only in how they interact with ‘the’. I argue that the-predicativists have incorrectly discerned the syntactic facts. They have bypassed a large range of important syntactic data and misconstrued a critical data point on which (...) they ground the-predicativism. The right data offers new compelling syntactic grounds for referentialism. (shrink)

lnfallibilism about a priori justification is the thesis that for an agent A to be a priori justified in believing p, that which justifies A’s belief that p must guarantee the truth of p. No analogous thesis is thought to obtain for empirically justified beliefs. The aim of this article is to argue that infallibilism about the a priori is an untenable philosophical position and to provide theoretical understanding why we not only can be, but rather must be, a priori (...) justified in believing some false propositions. The argument develops notions of obviousness and conceptual understanding as a means of affording insight into the conditions for having a priori justification and, consequently, into why infallibilism cannot stand. (shrink)

Our gender identity is our sense of ourselves as a woman, a man, as genderqueer, or as another gender. Our gender is the property we have of being a woman, being a man, being non-binary, or being another gender. What is the relationship between our gender identity and our gender? Recently, much work has been done on ameliorative accounts of the gender concepts that we should accept and on the metaphysics of gender properties. From this work 4 views of the (...) relationship between having gender identity G (e.g. having a female gender identity) and being a gender G (e.g. being a woman) have emerged. A first, the no connection view, says that gender identity and gender are entirely distinct; Sally Haslanger’s ameliorative account of gender, as well as Theodore Bach’s account of gender properties, are instances of this view. A second, the gender-identity-first view, says that all there is to our gender is our gender identity; this view is at least similar to views that Talia Bettcher and R.A. Briggs and B.R. George have argued for. A third, contextualist view, says that in some contexts and relative to certain standards, our gender identity determines our gender, and that in others it does not; Ásta and Robin Dembroff have proposed and defended views along these lines. A fourth view, the two gender properties view, says that there are two properties that can make it the case that one is gender G (in any context), one’s having gender identity G and one’s being socially classed as a G; Katharine Jenkins and Elizabeth Barnes have proposed views along these lines. This article explains these 4 different views and spells out their prospects, and the problems they face, as both ameliorative and as metaphysical views. (shrink)

This work defends an interrelated set of theses in value-theory, normative ethics and meta-ethics. The three Parts correspond to these three areas. Part One (Value) defends a biocentric theory of moral standing, and then the coherence and objectivity of belief in intrinsic value, despite recent objections. Intrinsic value is located in the flourishing of living creatures; specifically, a neo-Aristotelian, species-relative account is supplied of wellbeing or flourishing, in terms of the development of the essential capacities of one's species. There follows (...) a theory of priorities, or of relative intrinsic value, in which the satisfaction of basic needs takes priority over other needs and over wants, and the interests of complex and sophisticated creatures over those of others, where they are at stake. Part Two defends a practice-consequentialist theory of the criteria of rightness and of obligation, which leaves room for supererogation, underpins our intuitions about justice, commends population growth only where it is genuinely desirable, and responds better than act-consequentialism to objections like that concerned with the separateness of persons. Part Three sifts meta-ethical theories, rejects moral relativism, and defends a cognitivist and naturalist meta-ethic. In defending analytical naturalism, it takes into account the latest literature on supervenience. By responding to recent discussions, this study supersedes my _Theory of Value and Obligation_ (1987). It is equipped with detailed end-notes and an ample bibliography, which could prove a research tool of itself. (shrink)

The influence of Aristotle, the prince of philosophers, on the intellectual history of the West is second to none. In this book, Jonathan Barnes examines Aristotle's scientific researches, his discoveries in logic and his metaphysical theories, his work in psychology and in ethics and politics, and his ideas about art and poetry, placing his teachings in their historical context.

This book presents the case for belief in both creation and evolution at the same time as rejecting creationism. Issues of meaning supply the context of inquiry; the book defends the meaningfulness of language about God, and also relates belief in both creation and evolution to the meaning of life. Meaning, it claims, can be found in consciously adopting the role of steward of the planetary biosphere, and thus of the fruits of creation. Distinctive features include a sustained case for (...) a realist understanding of language about God; a contemporary defence of some of the arguments for belief in God and in creation; a sifting of different versions of Darwinism and their implications for religious belief; a Darwinian account of the relation of predation and other apparent evils to creation; a new presentation of the argument, from the world's value to the purposiveness of evolution; and discussions of whether or not meaning itself evolves, and of religious and secular bases for belief in stewardship. (shrink)

In this article we critically evaluate Robin Le Poidevin's recent attempt to set out an argument for the ontological reduction of chemistry independently of intertheoretic reduction. We argue, firstly, that the argument he envisages applies only to a small part of chemistry, and that there is no obvious way to extend it. We argue, secondly, that the argument cannot establish the reduction of chemistry, properly so called.

Thomas Hobbes has recently been cast as one of the forefathers of political realism. This article evaluates his place in the realist tradition by focusing on three key themes: the priority of legitimacy over justice, the relation between ethics and politics, and the place of imagination in politics. The thread uniting these themes is the importance Hobbes placed on achieving a moral consensus around peaceful coexistence, a point which distances him from realists who view the two as competing goals of (...) politics. The article maintains that only a qualified version of the autonomy of the political position can be attributed to Hobbes, while arguing more generally that attending to the relation between ethics and politics is central to assessing his liberal credentials from a realist perspective. Against the prevalent reading of Hobbes as a hypothetical contract theorist, the article proceeds to show that the place of consent in his theory is better understood as part of his wider goal of transforming the imagination of his audience: a goal which is animated by concerns that realists share. (shrink)

Robin illustrates the central role that fear has played and continues to play in the wielding of power, particularly in politics and the workplace.

This paper investigates whether gender affects ethically sensitive decisions of a personal or business nature. Data from 51 practicing accountants from both public accounting and private industry suggest that while differences exist between female and male accountants in responses to specific situations, overall responses are quite similar. Statistically significant differences were found for only five of the sixteen ethically sensitive situations. Further, when personal and business situations of a similar nature were paired together, two of the eight differences between personal (...) and business responses were significantly different between females and males. Taken as a whole, the results refute the suggestion that the ethical decision making of organizations may be enhanced as more women enter the business field. (shrink)

This article analyzes the relationship between the ideas of cruelty and injustice in Judith Shklar’s political theory. Shklar’s The Faces of Injustice is sometimes read as an instantiation of the liberalism of fear, which regards cruelty and the fear that it inspires as the summum malum. I challenge this interpretation and instead argue that her account of injustice should be read independently of her commitment to the liberalism of fear. In doing so, I show how her exploration of the faces (...) of injustice—especially the importance she accords to passive injustice and the sense of injustice—raises important challenges for the liberal case for putting cruelty first. Although democratic attitudes and institutions constitute the best available remedy for the sense of injustice, on Shklar’s account, those who focus too much on the requirements of democratic citizenship risk treating injustice as a greater evil than cruelty, which could, in turn, facilitate cruelty and undermine liberal democracy. I conclude by suggesting that the republican-inspired theory of citizenship from The Faces of Injustice, which Shklar outlines in response to the problem of passive injustice, reflects a distinct strand of her political theory that goes beyond the more familiar defense of law-bound constitutional government associated with the liberalism of fear. (shrink)

_ Source: _Volume 31, Issue 1, pp 30 - 47 In this article, I show that Hobbes’s account of the generation of the commonwealth in both _The Elements of Law_ and _De Cive_ relies on ideas that he would come to theorise in terms of authorisation and representation in _Leviathan_. In this respect, I argue that the _Leviathan_ account is better understood as filling in gaps and resolving equivocations in Hobbes’s theory, rather than marking a decisive break in his thinking. (...) This argument is developed by substantiating two more specific theses. First, while Hobbes only explicitly distinguishes between the “alienation” and “authorisation” clauses of the covenant in _Leviathan_, the earlier versions of his theory rely on a two-clause account. Second, in the earlier versions of his theory, Hobbes equivocates between suggesting that the relation between the state and sovereign should be understood in terms of representation or identity; an equivocation that he would only resolve in _Leviathan_. (shrink)

Thomas Hobbes has recently been cast as one of the forefathers of political realism. This article evaluates his place in the realist tradition by focusing on three key themes: the priority of legit...

An ambitious and wide-ranging synthesis of the history of environmental thought by a leading philosopher.

Richard Peters pioneered a form of philosophical analysis in relation to educational discourse that was criticised by some at the time and is today somewhat out of fashion. This paper argues that much of the objection to Peters' methodology is based on a misunderstanding of what it does and does not involve, that consequently philosophical analysis is often wrongly seen as one of a number of comparable alternative traditions or approaches to philosophy of education between which one needs to choose, (...) and that, partly consequentially, there is a relative lack of philosophical expertise among today's ‘philosophers of education’. Furthermore, his methodology vindicated, it can be said that Peters was indeed ‘nearly right about education’, perhaps more so than he has subsequently come to believe himself. (shrink)

This paper offers a defense of Charles Parsons’ appeal to mathematical intuition as a fundamental factor in solving Benacerraf’s problem for a non-eliminative structuralist version of Platonism. The literature is replete with challenges to his well-known argument that mathematical intuition justifies our knowledge of the infinitude of the natural numbers, in particular his demonstration that any member of a Hilbertian stroke string ω-sequence has a successor. On Parsons’ Kantian approach, this amounts to demonstrating that for an “arbitrary” or “vaguely represented” (...) string of strokes, we can always “add” one more stroke. Critics have contested the cogency of a notion of an arbitrary object, our capacity to vaguely represent a definite object, and the role of spatial and temporal representation in the demonstration that we can “add” one more. The bulk of this paper is devoted to demonstrating how to meet all extant criticisms of his key argument. Critics have also suggested that Parsons’ whole approach is misbegotten because the appeal to mathematical intuition inevitably falls short of providing a complete solution to Benacerraf’s problem. Since the natural numbers are essentially and exclusively characterized by their structural properties, they cannot be identified with any particular model of arithmetic, and thus a notion of intuition will fail to capture the universality of arithmetic, its applicability to all entities. This paper also explains why we should not reject appeal to mathematical intuition even though it is not itself sufficient to fully “close the gap” on Benacerraf’s challenge. (shrink)

The epistemological argument against descriptivism about proper names is extremely simple. Fora proper name ‘N’ and definite description ‘F’, the proposition expressed by “If N exists, then N is F is not normally known a priori. But descriptivism about proper names entails otherwise. So descriptivism is false. The argument is widely regarded as sound. This paper aims to establish that the epistemological argument is highly unstable. The problem with the argument is that there seems to be no convincing rationale for (...) the first premise that is independent of a view about the nature of the proposition expressed by the sentence “If N exists, then N is F”. (shrink)