This authored monograph introduces a genuinely theoretical approach to biology. Starting point is the investigation of empirical biological scaling including their variability, which is found in the literature, e.g. allometric relationships, fractals, etc. The book then analyzes two different aspects of biological time: first, a supplementary temporal dimension to accommodate proper biological rhythms; secondly, the concepts of protension and retention as a means of local organization of time in living organisms. Moreover, the book investigates the role of symmetry in biology, (...) in view of its ubiquitous importance in physics. In relation with the notion of extended critical transitions, the book proposes that organisms and their evolution can be characterized by continued symmetry changes, which accounts for the irreducibility of their historicity and variability. The authors also introduce the concept of anti-entropy as a measure for the potential of variability, being equally understood as alterations in symmetry. By this, the book provides a mathematical account of Gould's analysis of phenotypic complexity with respect to biological evolution. The target audience primarily comprises researchers interested in new theoretical approaches to biology, from physical, biological or philosophical backgrounds, but the book may also be beneficial for graduate students who want to enter this field. (shrink)

We provide a new perspective on the relation between the space of description of an object and the appearance of novelties. One of the aims of this perspective is to facilitate the interaction between mathematics and historical sciences. The definition of novelties is paradoxical: if one can define in advance the possibles, then they are not genuinely new. By analyzing the situation in set theory, we show that defining generic (i.e., shared) and specific (i.e., individual) properties of elements of a (...) set are radically different notions. As a result, generic and specific definitions of possibilities cannot be conflated. We argue that genuinely stating possibilities requires that their meaning has to be made explicit. For example, in physics, properties playing theoretical roles are generic; then, generic reasoning is sufficient to define possibilities. By contrast, in music, we argue that specific properties matter, and generic definitions become insufficient. Then, the notion of new possibilities becomes relevant and irreducible. In biology, among other examples, the generic definition of the space of DNA sequences is insufficient to state phenotypic possibilities even if we assume complete genetic determinism. The generic properties of this space are relevant for sequencing or DNA duplication, but they are inadequate to understand phenotypes. We develop a strong concept of biological novelties which justifies the notion of new possibilities and is more robust than the notion of changing description spaces. These biological novelties are not generic outcomes from an initial situation. They are specific and this specificity is associated with biological functions, that is to say, with a specific causal structure. Thus, we think that in contrast with physics, the concept of new possibilities is necessary for biology. (shrink)

Unlike inert objects, organisms and their cells have the ability to initiate activity by themselves and thus change their properties or states even in the absence of an external cause. This crucial difference led us to search for principles suitable for the study organisms. We propose that cells follow the default state of proliferation with variation and motility, a principle of biological inertia. This means that in the presence of sufficient nutrients, cells will express their default state. We also propose (...) a principle of variation that addresses two central features of organisms, variation and historicity. To address interdependence between parts, we use a third principle, the principle of organization, more specifically, the notion of the closure of constraints. Within this theoretical framework, constraints are specific theoretical entities defined by their relative stability with respect to the processes they constrain. Constraints are mutually dependent in an organized system and act on the default state.Here we discuss the application and articulation of these principles for mathematical modeling of morphogenesis in a specific case, that of mammary ductal morphogenesis, with an emphasis on the default state. Our model has both a biological component, the cells, and a physical component, the matrix that contains collagen fibers. Cells are agents that move and proliferate unless constrained; they exert mechanical forces that act (i) on collagen fibers and (ii) on other cells. As fibers are organized, they constrain the cells’ ability to move and to proliferate. This model exhibits a circularity that can be interpreted in terms of the closure of constraints. Implementing our mathematical model shows that constraints to the default state are sufficient to explain the formation of mammary epithelial structures. Finally, the success of this modeling effort suggests a stepwise approach whereby additional constraints imposed by the tissue and the organism can be examined in silico and rigorously tested by in vitro and in vivo experiments, in accordance with the organicist perspective we embrace. (shrink)

We characterize access to empirical objects in biology from a theoretical perspective. Unlike objects in current physical theories, biological objects are the result of a history and their variations continue to generate a history. This property is the starting point of our concept of measurement. We argue that biological measurement is relative to a natural history which is shared by the different objects subjected to the measurement and is more or less constrained by biologists. We call symmetrization the theoretical and (...) often concrete operation which leads to considering biological objects as equivalent in a measurement. Last, we use our notion of measurement to analyze research strategies. Some strategies aim to bring biology closer to the epistemology of physical theories, by studying objects as similar as possible, while others build on biological diversity. (shrink)

The Anthropocene crisis is frequently described as the rarefaction of resources or resources per capita. However, both energy and minerals correspond to fundamentally conserved quantities from the perspective of physics. A specific concept is required to understand the rarefaction of available resources. This concept, entropy, pertains to energy and matter configurations and not just to their sheer amount. However, the physics concept of entropy is insufficient to understand biological and social organizations. Biological phenomena display both historicity and systemic properties. A (...) biological organization, the ability of a specific living being to last over time, results from history, expresses itself by systemic properties, and may require generating novelties The concept of anti-entropy stems from the combination of these features. We propose that Anthropocene changes disrupt biological organizations by randomizing them, that is, decreasing anti-entropy. Moreover, second-order disruptions correspond to the decline of the ability to produce functional novelties, that is, to produce anti-entropy. (shrink)

This paper proposes an abstract mathematical frame for describing some features of biological time. The key point is that usual physical (linear) representation of time is insufficient, in our view, for the understanding key phenomena of life, such as rhythms, both physical (circadian, seasonal …) and properly biological (heart beating, respiration, metabolic …). In particular, the role of biological rhythms do not seem to have any counterpart in mathematical formalization of physical clocks, which are based on frequencies along the usual (...) (possibly thermodynamical, thus oriented) time. We then suggest a functional representation of biological time by a 2-dimensional manifold as a mathematical frame for accommodating autonomous biological rhythms. The “visual” representation of rhythms so obtained, in particular heart beatings, will provide, by a few examples, hints towards possible applications of our approach to the understanding of interspecific differences or intraspecific pathologies. The 3- dimensional embedding space, needed for purely mathematical reasons, allows to introduce a suitable extra-dimension for “representation time”, with a cognitive significance. (shrink)

The Anthropocene crisis is frequently described as the rarefaction of resources or resources per capita. However, both energy and minerals correspond to fundamentally conserved quantities from the perspective of physics. A specific concept is required to understand the rarefaction of available resources. This concept, entropy, pertains to energy and matter configurations and not just to their sheer amount. However, the physics concept of entropy is insufficient to understand biological and social organizations. Biological phenomena display both historicity and systemic properties. A (...) biological organization, the ability of a specific living being to last over time, results from history, expresses itself by systemic properties, and may require generating novelties The concept of anti-entropy stems from the combination of these features. We propose that Anthropocene changes disrupt biological organizations by randomizing them, that is, decreasing anti-entropy. Moreover, second-order disruptions correspond to the decline of the ability to produce functional novelties, that is, to produce anti-entropy. (shrink)

Symmetries play a major role in physics, in particular since the work by E. Noether and H. Weyl in the first half of last century. Herein, we briefly review their role by recalling how symmetry changes allow to conceptually move from classical to relativistic and quantum physics. We then introduce our ongoing theoretical analysis in biology and show that symmetries play a radically different role in this discipline, when compared to those in current physics. By this comparison, we stress that (...) symmetries must be understood in relation to conservation and stability properties, as represented in the theories. We posit that the dynamics of biological organisms, in their various levels of organization, are not just processes, but permanent (extended, in our terminology) critical transitions and, thus, symmetry changes. Within the limits of a relative structural stability (or interval of viability), variability is at the core of these transitions. (shrink)

CRAN R code to analyze disruption of plant-pollinator networks for the article: Disruption of biological processes in the Anthropocene: the case of phenological mismatch Cite as Montévil, M. 2020, code for: Disruption of biological processes in the Anthropocene: the case of phenological mismatch DOI: 10.5281/zenodo.4290412.

Biologists increasingly report anthropogenic disruptions of both organisms and ecosystems, suggesting that these processes are a fundamental, qualitative component of the Anthropocene. Nonetheless, the notion of disruption has not yet been theorized in biology. To progress in that regard, we work on a special case. Relatively minor temperature changes impact plant-pollinator synchrony, disrupting mutualistic interaction networks. Understanding this phenomenon requires a specific rationale since models describing them use both historical and systemic reasoning. Specifically, history justifies that the system is initially (...) in a very narrow part of the possibility space where it is viable, and the disruption randomizes this configuration. Building on this rationale, we develop a formal framework inspired by Boltzmann's entropy. With empirical networks, we show historical trends depending on latitude. Then we propose an initial definition of disruption in ecology. When a specific historical outcome contributes to a system's viability, disruption randomizes this outcome, decreasing viability. (shrink)

The analogy between living beings and computers was introduced with circumspection by Schrödinger and has been widely propagated since, rarely with a precise technical meaning. Critics of this perspective are numerous. We emphasize that this perspective is mobilized to justify what may be called a regressive reductionism by comparison with physics or the Cartesian method. Other views on the living are possible, and we focus on an epistemological and theoretical framework where historicity is central, and the regularities susceptible to mathematization (...) are constraints whose existence is fundamentally precarious and historically contingent. We then propose to reinterpret the computer, no longer as a Turing machine but as constituted by constraints. This move allows us to understand that computation in the sense of Church-Turing is only a part of the theoretical determination of what actually happens in a computer when considering them in their larger theoretical context where historicity is also central. (shrink)

Open peer commentary on the article “What Is a Cognizing Subject? Construction, Autonomy and Original Causation” by Niall Palfreyman & Janice Miller-Young. Upshot: I discuss convergences between the approach of the authors and my work aiming for a theory of organisms. I also discuss some pitfalls and challenges pertaining to biological randomness, which, I argue, require original developments.

This article proposes an abstract mathematical frame for describing some features of cognitive and biological time. We focus here on the so called “extended present” as a result of protentional and retentional activities (memory and anticipation). Memory, as retention, is treated in some physical theories (relaxation phenomena, which will inspire our approach), while protention (or anticipation) seems outside the scope of physics. We then suggest a simple functional representation of biological protention. This allows us to introduce the abstract notion of (...) “biological inertia”. (shrink)

In this paper, we apply the perspective of intra-organismal ecology by investigating a family of ecological models suitable to describe a gene therapy to a particular metabolic disorder, the adenosine deaminase deficiency (ADA-SCID). The gene therapy is modeled as the prospective ecological invasion of an organ (here, bone marrow) by genetically modified stem cells, which then operate niche construction in the cellular environment by releasing an enzyme they synthesize. We show that depending on the chosen order (a choice that cannot (...) be made on \textit{a priori} assumptions), different kinds of dynamics are expected, possibly leading to different therapeutic strategies. This drives us to discuss several features of the extension of ecology to intra-organismal ecology. (shrink)

The physical singularity of life phenomena is analyzed by means of comparison with the driving concepts of theories of the inert. We outline conceptual analogies, transferals of methodologies and theoretical instruments between physics and biology, in addition to indicating significant differences and sometimes logical dualities. In order to make biological phenomenalities intelligible, we introduce theoretical extensions to certain physical theories. In this synthetic paper, we summarize and propose a unified conceptual framework for the main conclusions drawn from work spanning a (...) book and several articles, quoted throughout. (shrink)

In this paper, we discuss the perspective of intra-organismal ecology by investigating a family of ecological models. We consider two types of models. First order models describe the population dynamics as being directly affected by ecological factors (here understood as nutrients, space, etc). They might be thought of as analogous to Aristotelian physics. Second order models describe the population dynamics as being indirectly affected, the ecological factors now affecting the derivative of the growth rate (that is, the population acceleration), possibly (...) through an impact on non-genetically inherited factors. Second order models might be thought of as analogous to Galilean physics. In the joint paper, we apply these ideas to a situation of gene therapy. (shrink)

n this text, we revisit part of the analysis of anti-entropy in Bailly and Longo (2009} and develop further theoretical reflections. In particular, we analyze how randomness, an essential component of biological variability, is associated to the growth of biological organization, both in ontogenesis and in evolution. This approach, in particular, focuses on the role of global entropy production and provides a tool for a mathematical understanding of some fundamental observations by Gould on the increasing phenotypic complexity along evolution. Lastly, (...) we analyze the situation in terms of theoretical symmetries, in order to further specify the biological meaning of anti-entropy as well as its strong link with randomness. (shrink)

The book A critical overview of biological functions is a short monograph by J. Garson, which provides a survey of the views on biological functions in the analytic tradition of philosophy. The notion of function is ubiquitous in biology and all of its subfields. Behind the notion of biological functions lurks the shadow of final causes. Overcoming this shadow is a challenge that has stimulated many philosophers and the literature on this topic is very rich. In the analytic tradition, researchers (...) focus on providing naturalized accounts of functions. To do so, the main difficulty is to provide accounts of functions that exclude the use of final causes. The outcome of this collective work is a diversity of accounts of functions. Some of these accounts are fairly recent while others have been proposed several decades ago and are the object of many discussions. (shrink)

Emotive speech is a social act in which a speaker displays emotional signals with a specific intention; in the case of third-party complaints, this intention is to elicit empathy in the listener. The present study assessed how the emotivity of complaints was perceived in various conditions. Participants listened to short statements describing painful or neutral situations, spoken with a complaining or neutral prosody, and evaluated how complaining the speaker sounded. In addition to manipulating features of the message, social-affiliative factors which (...) could influence complaint perception were varied by adopting a cross-cultural design: participants were either Québécois or French and listened to utterances expressed by both cultural groups. The presence of a complaining tone of voice had the largest effect on participant evaluations, while the nature of statements had a significant, but smaller influence. Marginal effects of culture on explicit evaluation of complaints were found. A multiple mediation analysis suggested that mean fundamental frequency was the main prosodic signal that participants relied on to detect complaints, though most of the prosody effect could not be linearly explained by acoustic parameters. These results highlight a tacit agreement between speaker and listener: what characterizes a complaint is how it is said, more than what it is about or who produces it. More generally, the study emphasizes the central importance of prosody in expressive speech acts such as complaints, which are designed to strengthen social bonds and supportive responses in interactive behavior. This intentional and interpersonal aspect in the communication of emotions needs to be further considered in research on affect and communication. (shrink)

Zeno’s paradoxes of motion, allegedly denying motion, have been conceived to reinforce the Parmenidean vision of an immutable world. The aim of this article is to demonstrate that these famous logical paradoxes should be seen instead as paradoxes of immobility. From this new point of view, motion is therefore no longer logically problematic, while immobility is. This is convenient since it is easy to conceive that immobility can actually conceal motion, and thus the proposition “immobility is mere illusion of the (...) senses” is much more credible than the reverse thesis supported by Parmenides. Moreover, this proposition is also supported by modern depiction of material bodies: the existence of a ceaseless random motion of atoms—the ‘thermal agitation’—in the scope of contemporary atomic theory, can offer a rational explanation of this ‘illusion of immobility’. Our new approach to Zeno’s paradoxes therefore leads to presenting the novel concept of ‘impermobility’, which we think is a more adequate description of physical reality. (shrink)

La route antique de Mégare à Thèbes par le défilé du Kandili, dont on a contesté à tort l'existence, correspond à un chemin encore très utilisé au xixe siècle, le Koulouriotiko monopati. Description des restes antiques de cette route et des sites antiques situés tout le long. Les témoignages des historiens antiques sur son utilisation.

Since the turn of the twenty-first century, biomedical psychiatry around the globe has embraced the so-called precision medicine paradigm, a model for medical research that uses innovative techniques for data collection and analysis to reevaluate traditional theories of disease. The goal of precision medicine is to improve diagnostics by restratifying the patient population on the basis of a deeper understanding of disease processes. This paper argues that precision is ill-fitting for psychiatry for two reasons. First, in psychiatry, unlike in fields (...) like oncology, precision medicine has been understood as an attempt to improve medicine by casting out, rather than merely revising, traditional taxonomic tools. Second, in psychiatry the term “biomarker” is often used in reference to signs or symptoms that allow patients to be classified and then matched with treatments; however, in oncology “biomarker” usually refers to a disease mechanism that is useful not only for diagnostics, but also for discovering causal pathways that drug therapies can target. Given these differences between how the precision medicine paradigm operates in psychiatry and in other medical fields like oncology, while precision psychiatry may offer successful rhetoric, it is not a promising paradigm. (shrink)

It is commonly believed that there is no equivalent of the Church–Turing thesis for computation over the reals. In particular, computational models on this domain do not exhibit the convergence of formalisms that supports this thesis in the case of integer computation. In the light of recent philosophical developments on the different meanings of the Church–Turing thesis, and recent technical results on analog computation, I will show that this current belief confounds two distinct issues, namely the extension of the notion (...) of effective computation to the reals on the one hand, and the simulation of analog computers by Turing machines on the other hand. I will argue that it is possible in both cases to defend an equivalent of the Church–Turing thesis over the reals. Along the way, we will learn some methodological caveats on the comparison of different computational models, and how to make it meaningful. (shrink)

While relatively unknown to Anglophone circles, there was a thriving Anabaptist community in Italy during the reformation. It is the scope of this article to help retrace the origins of the Anabaptist movement in Italy and to set straight some misconceptions unintentionally perpetuated by some who have attempted this journey in the past. This is done in the hopes of raising appreciation for the movement and of enticing future research interest in this forgotten branch of the Radical Reformation.

Conceptual analysis of health and disease is portrayed as consisting in the confrontation of a set of criteria—a “definition”—with a set of cases, called instances of either “health” or “ disease.” Apart from logical counter-arguments, there is no other way to refute an opponent’s definition than by providing counter-cases. As resorting to intensional stipulation is not forbidden, several contenders can therefore be deemed to have succeeded. This implies that conceptual analysis alone is not likely to decide between naturalism and normativism. (...) An alternative to this approach would be to examine whether the concept of disease can be naturalized. (shrink)

Biological evolution is a complex blend of ever changing structural stability, variability and emergence of new phe- notypes, niches, ecosystems. We wish to argue that the evo- lution of life marks the end of a physics world view of law entailed dynamics. Our considerations depend upon dis- cussing the variability of the very ”contexts of life”: the in- teractions between organisms, biological niches and ecosys- tems. These are ever changing, intrinsically indeterminate and even unprestatable: we do not know ahead of (...) time the ”niches” which constitute the boundary conditions on selec- tion. More generally, by the mathematical unprestatability of the ”phase space”, no laws of mo- tion can be formulated for evolution. We call this radical emergence, from life to life. The purpose of this paper is the integration of variation and diversity in a sound concep- tual frame and situate unpredictability at a novel theoretical level, that of the very phase space. Our argument will be carried on in close comparisons with physics and the mathematical constructions of phase spaces in that discipline. The role of symmetries as invariant preserving transformations will allow us to under- stand the nature of physical phase spaces and to stress the differences required for a sound biological theoretizing. In this frame, we discuss the novel notion of ”enablement”. Life lives in a web of enablement and radical emergence. This will restrict causal analyses to differential cases. Mutations or other causal differ- ences will allow us to stress that ”non conservation princi- ples” are at the core of evolution, in contrast to physical dynamics, largely based on conservation principles as sym- metries. Critical transitions, the main locus of symmetry changes in physics, will be discussed, and lead to ”extended criticality” as a conceptual frame for a better understanding of the living state of matter. (shrink)

Aging is an elusive property of life, and many important questions about aging depend on its definition. This article proposes to draw a definition from the scientific literature on aging. First, a broad review reveals five features commonly used to define aging: structural damage, functional decline, depletion, typical phenotypic changes or their cause, and increasing probability of death. Anything that can be called ‘aging’ must present one of these features. Then, although many conditions are not consensual instances of aging, aging (...) is consensually described as a process of loss characterized by a rate and resulting from the counteraction of protective mechanisms against mechanisms that limit lifespan. Beyond such an abstract definition, no one has yet succeeded in defining aging by a specific mechanism of aging because of an explanatory gap between such a mechanism and lifespan, a consensual explanandum of a theory of aging. By contrast, a sound theoretical definition can be obtained by revisiting the evolutionary theory of aging. Based on this theory, aging evolves thanks to the impossibility that natural selection eliminates late traits that are neutral mainly due to decreasing selective pressure. Yet, the results of physiological research suggest that this theory should be revised to also account for the small number of different aging pathways and for the existence of mechanisms counteracting these pathways, that must, on the contrary, have been selected. A synthetic, but temporary definition of aging can finally be proposed. (shrink)

Cet article présente un état de l'art critique du sous-champ de l'éthique de l'Intelligence Artificielle nommé "équité algorithmique". Il se concentre en particulier sur un objet récent, mais faisant objet d'une activité intense, à savoir les critières statistiques de l'équité algorithmique. Il s'agit de critères permettant de déterminer si un algorithme ou modèle prédictif de ML ne présente pas de biais défavorable à l'égard d'une population donnée en examinant les caractéristiques statistiques de son comportement entrées-sortie. Nous commençons par présenter les (...) diverses définitions au centre des conversations récentes, ainsi qu'un résultat crucial d'impossibilité d'optimisation simultanée de toutes ces métriques, nommé "résultat d'incompatibilité." Nous discutons ensuite les leçons philosophiques à tirer de cette pluralité de définitions et du résultat d'incompatibilité. Nous finissons par une discussion critique portant sur les difficultés provenant de la représentation par des variables mathématiques de réalités sociales complexes comme l'appartenance identitaire à une population donnée, ou la caractérisation d'un discours comme discours de haine. (shrink)

La thèse de Church-Turing stipule que toute fonction calculable est calculable par une machine de Turing. En distinguant, à la suite de nombreux auteurs, une forme algorithmique de la thèse de Church-Turing portant sur les fonctions calculables par un algorithme d’une forme empirique de cette même thèse, portant sur les fonctions calculables par une machine, il devient possible de poser une nouvelle question : les limites empiriques du calcul sont-elles identiques aux limites des algorithmes ? Ou existe-t-il un moyen empirique (...) d’effectuer un calcul qu’aucun algorithme ne permet d’effectuer ? Je montrerai ici la pertinence philosophique de cette question. Elle interroge la capacité de processus symboliques comme les calculs à simuler certains processus empiriques. Elle permet également d’étudier le statut épistémologique des calculs réalisés par des machines. S’il existait une fonction calculable par une machine sans être calculable par un algorithme, il existerait un problème mathématique qui serait soluble par un dispositif empirique, sans être soluble par aucune méthode mathématique a priori. (shrink)

La thèse de Church-Turing stipule que toute fonction calculable est calculable par une machine de Turing. En distinguant, à la suite de nombreux auteurs, une forme algorithmique de la thèse de Church-Turing portant sur les fonctions calculables par un algorithme d’une forme empirique de cette même thèse, portant sur les fonctions calculables par une machine, il devient possible de poser une nouvelle question : les limites empiriques du calcul sont-elles identiques aux limites des algorithmes? Ou existe-t-il un moyen empirique d’effectuer (...) un calcul qu’aucun algorithme ne permet d’effectuer? Je montrerai ici la pertinence philosophique de cette question. Elle interroge la capacité de processus symboliques comme les calculs à simuler certains processus empiriques. Elle permet également d’étudier le statut épistémologique des calculs réalisés par des machines. S’il existait une fonction calculable par une machine sans être calculable par un algorithme, il existerait un problème mathématique qui serait soluble par un dispositif empirique, sans être soluble par aucune méthode mathématique a priori. (shrink)

According to the received view, the transportation view, animal extrapolation consists in inductive prediction of the outcome of a mechanism in a target, based on an analogical mechanism in a model. Through an analysis of the failure of preclinical studies of TGN1412, an innovative drug, to predict the tragic consequences of its first-in-man trial in 2006, the received view is challenged by a proposed view of animal extrapolation, the chimera view. According to this view, animal extrapolation is based on a (...) hypothesis about how human organisms work, supported by the amalgamation of results drawn from various experimental organisms, and only predicting the ‘predictive grid’, that is, a global framework of the effects to be expected. (shrink)

Science starts by using terms such as ‘temperature’ or ‘fish’ or ‘gene’ to preliminarily delimitate the extension of a phenomenon, and concludes by giving most of them a technical meaning based on an explanatory model. This transforma- tion of the meaning of the term is an essential part of its naturalization. Debating on the definition of ‘disease’, what most philosophers of medicine have examined is the pre-naturalized meaning of the term: for that reason they have focused on the task of (...) delimiting disease and non-disease (health), mainly used conceptual analysis as a method of choice, and considered the nosological level of ‘disease judgments’ rather than the pathophysiological or psychopathological level of disease mechanisms, thus making them impervious to most scientific discoveries. By focusing instead on the naturalized concept of disease and following some suggestions by philosophers of biology and scientists in cutting-edge fields of biomedical research, they could gar- ner results from a comparison of the mechanisms of diseases. This would ultimately result in a general theory of disease linked with our most general theories on living beings, among them, systems biology and network medicine. Before undertaking such a task, preliminary questions arise: is it likely that there are biological features common to different types of disease? Is it a philosopher’s job to determine what they consist in? What use would such a general theoretical definition of disease be? (shrink)

Despite its vagueness Personalized, Precision, P4, P5, individualized, stratified medicine—or p-medicine in short—has become an increasingly popular term in biomedical literature. Philosophers have attempted to analyze what these various terms involve and have discussed consequences for medical practices. In this article, I argue that an important question remains unaddressed: what has made this project of p-medicine convincing to so many? My argument is that without real achievements, it would never have been. I also make the case that these achievements stem (...) from the domain of monoclonal antibodies, a new type of drug that justifies talks of personalized, precise, stratified, etc., medicine. In conclusion, while it may be possible to label any projection in the future of medicine as ‘p-medicine’, it is impossible to overlook mab-medicine as the spearhead. (shrink)

Following the neurophenomenological approach, we propose a model of emotional emergence that identifies the experimental structures of time involved in emotional experience and their plausible components in terms of cognition, physiology, and neuroscience. We argue that surprise, as a lived experience, and its physiological correlates of the startle reflex and cardiac defense are the core of the dynamic, and that the heart system sets temporally in motion the dynamic of emotional emergence. Finally, in reference to Craig’s model of emotion, we (...) propose an integrative model of the temporal dynamic of emotional emergence that allows emotions to be distinguished depending on each temporal phase and that involves the following three systems: the brain , the consciousness , and the doubled-sided continuum of the body-heart context, with the heart as the focus within the body during emotion. This model provides the framework for future developments in 1st- and 3rd-person approaches for an integrative understanding of the science of emotion, including the fields of psychophysiology and psychopathology. (shrink)

La thèse de Church-Turing stipule que toute fonction calculable est calculable par une machine de Turing. En distinguant, à la suite de nombreux auteurs, une forme algorithmique de la thèse de Church-Turing portant sur les fonctions calculables par un algorithme d’une forme empirique de cette même thèse, portant sur les fonctions calculables par une machine, il devient possible de poser une nouvelle question : les limites empiriques du calcul sont-elles identiques aux limites des algorithmes? Ou existe-t-il un moyen empirique d’effectuer (...) un calcul qu’aucun algorithme ne permet d’effectuer? Je montrerai ici la pertinence philosophique de cette question. Elle interroge la capacité de processus symboliques comme les calculs à simuler certains processus empiriques. Elle permet également d’étudier le statut épistémologique des calculs réalisés par des machines. S’il existait une fonction calculable par une machine sans être calculable par un algorithme, il existerait un problème mathématique qui serait soluble par un dispositif empirique, sans être soluble par aucune méthode mathématique a priori. (shrink)

A survey is given of the concepts of interaction (force) and matter, i.e., of process and substance. The development of these concepts, first in antiquity, then in early modern times, and finally in the contemporary system of quantum field theory is described. After a summary of the basic phenomenological attributes (coupling strengths, symmetry quantities, charges), the common ground of concepts of quantum field theory for both interactions and matter entities is discussed. Then attention is focused on the gauge principle which (...) has been developed to describe all interaction fields in the same way, and hopefully to unite them all into one unified field. While a similar unification of all fundamental types of matter fields (quarks and leptons) into one family may be possible (SU 5), there still remains at this level a duality between interaction quanta (bosons with spin 1) and matter particles (fermions with spin 1/2). Whether this duality may be removed in some future supersymmetric theory is not discussed in this paper. Nor is Quantum Gravitation discussed, though the analogy of the gauge principle for the three fundamental non-gravitational interactions (hadronic, electromagnetic and weak) to Einstein's principle of equivalence for gravitation in spacetime is noted. However, the equivalence concept is applied not to spacetime but to the internal spaces for the matter (or charge) fields which are the sources between which the fundamental interactions operate. The gauge principle states that a change in the measures of the internal space charge of gauge or phases of the matter fields is equivalent to, and can be compensated by, suitably introduced interaction fields. From such an interaction field, the gauge potential field in the internal space, one may derive a gauge force field by exterior differentiation.Geometrically, the collection of all internal spaces, one over each point of spacetime, constitutes a fiber bundle. The gauge potential field represents a connection on the fiber bundle, and the gauge force field is the curvature (calculated by taking the exterior derivative of the connection and adding to it the exterior product of the connection with itself). Thus, just as gravitational force is interpreted as spacetime curvature, so the three other fundamental forces are interpretable as internal space curvature. The Standard Model which unites the three non-gravitational fields into an SU c 3 ×SU 2×U 1 structure, and the grand unified model, SU 5, are discussed briefly, and difficulties are noted. Finally it is suggested that a composite model, based on more subtle structure, may be needed to remove the present obscurities and difficulties that stand in the way of a unified theory. (shrink)

The main thesis of this paper is that mental health practitioners can legitimately infer that a patient's given condition is a case of mental disorder without having diagnosed any specific mental disorder. The article shows how this is justifiable by relying either on psychopathological reasoning, on 'intentional' analysis or possibly on other modes of reasoning. In the end, it highlights the clinical and philosophical consequences of the plurality of modes of 'inferences to mental disorder'.

In our commentary on Lynch et al.’s target paper, we focus on decomposition as a research strategy. We argue that not only the presumptive microbial causes but also their supposed phenotypic effects need to be decomposed relative to each other. Such a dual decomposition strategy ought to improve the way in which causal claims in microbiome research can be made and understood.

In our commentary on Lynch et al.’s target paper, we focus on decomposition as a research strategy. We argue that not only the presumptive microbial causes but also their supposed phenotypic effects need to be decomposed relative to each other. Such a dual decomposition strategy ought to improve the way in which causal claims in microbiome research can be made and understood.

In our commentary on Lynch et al.’s target paper, we focus on decomposition as a research strategy. We argue that not only the presumptive microbial causes but also their supposed phenotypic effects need to be decomposed relative to each other. Such a dual decomposition strategy ought to improve the way in which causal claims in microbiome research can be made and understood.

A teacher-student relationship (TSR) characterized by closeness promotes student engagement and positive emotional experiences among teachers. The present systematic review questions what the English-language literature reports on the effect of training dedicated to the development of teachers' emotional competences (EC) on these competences and on the TSR quality. 17 articles met the inclusion criteria. The findings suggest that brief EC trainings can sustainably develop teachers’ EC. The small number of articles that have also evaluated the TSR quality prevents to conclude (...) as to the effects of these training courses on this variab. (shrink)

Philosophers of science have recently focused on the scientific activity of modeling phenomena, and explicated several of its properties, as well as the activities embedded into it. A first approach to modeling has been elaborated in terms of representing a target system: yet other epistemic functions, such as producing data or detecting phenomena, are at least as relevant. Additional useful distinctions have emerged, such as the one between phenomenological and mechanistic models. In biological sciences, besides mathematical models, models now come (...) in three forms: in vivo, in vitro and in silico. Each has been investigated separately, and many specific problems they raised have been laid out. Another relevant distinction is disciplinary: do models differ in significant ways according to the discipline involved—medicine or biology, evolutionary biology or earth science? Focusing on either this threefold distinction or the disciplinary boundaries reveals that they might not be sufficient from a philosophical perspective. On the contrary, focusing on the interaction between these various kinds of models, some interesting forms of explanation come to the fore, as is exemplified by the papers included in this issue. On the other hand, a focus on the use of models, rather than on their content, shows that the distinction between biological and medical models is theoretically sound. (shrink)

« Un coworking sans communauté n’existe pas. » Qu’est-ce qui sépare les nous du tiers-lieu de ceux de la start-up (plus ou moins nationalisée)? Qu’est-ce qui distingue les bretelles (d’un nous relativement dilaté, diffracté ou bifurquant) des autoroutes (du je au cœur du développement personnel comme du nous des team buildings et atelier de we design)? L’auto-affectation d’un soi mis au pluriel tente, par un simple jeu pronominal, de cacher son intention de relier tout le monde. À travers les reflets (...) de ces belles âmes dans leurs variations esthétiques, cet article se propose de penser les réactualisations de la standardisation psychique mondiale en montrant comme elles brouillent de quel entre-nous ça parle. On part d’une série de citations des stars de la république des lettres. Direct, on multiplie les formes de déterritorialisations énonciatives comme autant de traversées d’un nous attaché à son incertitude d’échelle et excité par ses anachronismes : expérience originelle de l’autre comme soi, atelier alter-constructiviste, méditation auto-décentrante, réunion anti-facilitatrice, contre-point sur la situation actuelle. (shrink)