We propose that interaction rules derived from polyamine exchange in connected cells may explain the spatio‐temporal organization of gap junctions observed during tissue regeneration and tumorigenesis. We also hypothesize that polyamine exchange can be considered as signal that allows cells to sense the proliferation status of their neighbors. Polyamines (putrescine, spermidine, and spermine) are indeed small aliphatic polycations that serve as fuels to sustain elevated proliferation rates of the order observed in cancer cells. Based on recent reports, we consider here (...) that polyamines can be exchanged through gap junction channels between mammalian cells. Such intercellular exchange of polyamines has critical consequences on the local control of growth. In line with this hypothesis, the complex protein network that keeps polyamine levels finely tuned in mammalian cells can translate polyamine efflux or influx into integrated signals controlling transcription, translation, and cell communications. (shrink)

Since the introduction and widespread adoption of chemical herbicides, “weed management” has become almost synonymous with “herbicide management.” Over-reliance on herbicides and herbicide-resistant crops has given rise to herbicide resistant weeds. Integrated weed management (IWM) identifies three strategies for weed management— biological-cultural, chemical-technological, mechanical-physical—and recommends combining all three to mitigate herbicide resistance. However, adoption of IWM has stalled, and research to understand the adoption of IWM practices has focused on single stakeholder groups, especially farmers. In contrast, decisions about weed management (...) often occur within a social ecosystem where multiple stakeholder groups co-create knowledge and practices. To more holistically investigate perceptions and decision-making related to herbicide resistant weed management, we conducted 23 in-depth interviews in combination with Q methodology with farmers and public-/private-sector agricultural professionals in the state of Georgia (U.S.). Our investigation focused on the management of an increasingly herbicide resistant weed, Palmer amaranth, which enabled broader conversations about agricultural systems, farmer livelihoods, and sustainability. Factor and thematic analyses allowed us to identify and characterize two distinct typologies: one primarily valued agronomic efficiency and relied upon chemical-technological management practices, while the other valued diversifying weed management strategies as the pathway to agronomic and economic success. Typologies diverged substantially in attitudes toward the three weed management strategies, the role of technology, and systems management generally. These two viewpoints have implications for how we understand underlying stakeholder motivations and choices around weed management strategies, both of which are crucial in promoting and supporting farmer use of diverse, ecologically-sound, weed management strategies. (shrink)

El propósito de este texto es abordar la problemática de las inteligencias artificiales y su incidencia en la sociedad contemporánea. Para ello, se realizan lecturas paralelas de las sociedades distópicas creadas por Isaac Asimov y Philip K. Dick. A partir de estas, se identifican algunos rasgos existentes en nuestro contexto inmediato, enfocándonos en tres ejes principales: la sociedad de vigilancia y control tecnológico, el problema de lo natural en los ciber-seres, y la visión del siglo XXI en la ciencia ficción (...) para analizar si esta es ilusoria o, por el contrario, forma parte de nuestra realidad inmediata. Todo esto con el fin de definir al género como un espejo de nuestro futuro, basándonos en la lectura de nuestro presente para interpretar los mundos posibles y el futuro como fuente de reflexión filosófica y tecnológica. En este artículo, analizaremos a grandes rasgos los elementos de la ciencia ficción de Isaac Asimov y Philip K. Dick, enfocándonos en aspectos como la naturalidad de los individuos, las sociedades de control y las líneas que separan lo humano de lo artificial como bases para la reflexión filosófica. A través de este ejercicio, examinaremos diversas obras de ambos autores, tales como El hombre bicentenario (Asimov 2019b), Satisfacción Garantizada (Asimov 2019a), La última pregunta (Asimov 2019a), ¿Sueñan los androides con ovejas eléctricas? (Dick 2017) y El hombre en el castillo (Dick 2021). El objetivo es identificar elementos que nos permitan interpretar el siglo XXI como una obra de ciencia ficción en constante desarrollo. (shrink)

Actualmente existe un debate en torno a la naturaleza del sistema nobi a lo largo de la historia de Corea. Podemos encontrar historiadores que definen el sistema nobi como un sistema de esclavitud y a los nobi como esclavos, y a historiadores que prefieren definirlo como un sistema de servidumbre y a los nobi como siervos. En este artículo se expone la interpretación que el historiador estadounidense James B. Palais ofreció sobre el sistema nobi en la dinastía Joseon de Corea (...) a partir de su producción intelectual, poniendo un mayor énfasis en la interpretación ofrecida en su obra Confucian Statecraft and Korean Institutions: Yu Hyongwon and the Late Choson Dynasty, además de exponer las influencias intelectuales que motivaron esta interpretación por parte de Palais. La interpretación de Palais sobre el sistema nobi reviviría el debate en torno a la naturaleza del sistema nobi y sentaría las bases de la interpretación del sistema nobi para los futuros historiadores de Corea. (shrink)

This is a masterly introduction to the modern, and rigorous, theory of probability. The author emphasises martingales and develops all the necessary measure theory.

Infectious diseases figure prominently as (counter)examples in debates on how to conceptualize “disease.” But crucial epidemiological distinctions are often not heeded in the debate, and pathological and clinical perspectives focusing on individual patients are favored at the expense of perspectives from epidemiology focusing on populations. In clarifying epidemiological concepts, this paper highlights the distinct contributions infectious disease epidemiology can make to the conception of “disease,” and the fact that this is at least tacitly recognized by medical personnel and philosophers. Crucially, (...) infectious disease epidemiology can help elucidate how carrying and transmitting infectious, communicable entities is a disease, even if the carriers themselves are not directly affected by symptoms detrimental to them. (shrink)

This paper develops a theory of belief and belief ascription which retains the core of the received Propositionalist theory but which, unlike the Propositionalist theory, is compatible with both Direct Reference and Individualism about belief. The focus is on developing an alternative analysis of belief ascriptions, drawing out its implications, and applying it to some standard problems. On that analysis, ascriptions involving directly referential embedded terms are seen as roughly characterizing, but not specifying, the contents of beliefs. This feature is (...) what makes it possible to maintain both Direct Reference and Individualism. (shrink)

Psychologists debate whether mental attributes can be quantified or whether they admit only qualitative comparisons of more and less. Their disagreement is not merely terminological, for it bears upon the permissibility of various statistical techniques. This article contributes to the discussion in two stages. First it explains how temperature, which was originally a qualitative concept, came to occupy its position as an unquestionably quantitative concept (§§1–4). Specifically, it lays out the circumstances in which thermometers, which register quantitative (or cardinal) differences, (...) became distinguishable from thermoscopes, which register merely qualitative (or ordinal) differences. I argue that this distinction became possible thanks to the work of Joseph Black, ca. 1760. Second, the article contends that the model implicit in temperature’s quantitative status offers a better way for thinking about the quantitative status of mental attributes than models from measurement theory (§§5–6). (shrink)

Interviews focusing on the last century take a look at history from the standpoint of the ordinary people of the country.

The growing interest in Africa as well as concerns about negative deviant behaviors and ethnic structures necessitates examination of the effect of ethnic expectations on behavior of employees. In this study we leverage insight from ethnos oblige theory to propose that centralization of ethnic norms moderates the relationship between benevolence expectations and negative deviant behavior. Using a cross-sectional design and data from two countries as well as moderation and cross-cultural analytic techniques, we find support for three-way interactions where the relationship (...) between benevolence and negative deviant behavior is moderated by centralization and culture. We discuss the implications of the findings which support the dynamic perspective of management in Africa. (shrink)

Nothing can kill a promising research program in ethics more quickly than a plausible argument to the effect that it is committed to a morally repellent consequence. It is especially troubling when a theory one favors is jeopardized in this way. I have this worry about Harry Frankfurt's theory of free will, autonomous agency and moral responsibility, for there is a very plausible argument to the effect that aspects of his view commit him to a version of the late Stoic (...) thesis that acting freely is a matter of ‘making do,’ that is, of bringing oneself to be motivated to act in accordance with the feasible, so that personal liberation can be achieved by resigning and adapting oneself to necessity. In this paper I try to determine whether the theory does in fact commit Frankfurt (and adherents like me) to this result and, if so, what can be done to prevent it. (shrink)

There has been considerable recent interest in the “collective moral autonomy” thesis (CMA), that is, the notion that we can predicate moral successes, failures, and duties of collectives even if there are no comparable successes, failures, and duties among members. One reason why this position looks appealing is because the opposing individualist position seems to have what we might call an accounting problem. Individualists maintain that only individuals can be subjects of moral success, failure, or duty; however, many reasonable judgments (...) about collective actions include moral information on a scale and of a stringency that it does not seem possible to predicate even of the duties of members who have steering power in the actions of the collective. Here I offer a paradigm for thinking about responsibility judgments in organized collective cases to help individualism solve its accounting problem, and allow us to account within a strict individualist perspective for moral information that ostensibly favors CMA. (shrink)

In this paper, I develop two criticisms of L. Jonathan Cohen's influential a priori argument that human irrationality cannot be experimentally demonstrated. The first is that the argument depends crucially on the concept of a normal human but that no such concept suitable for Cohen's purposes is available. The second is that even if his argument were granted, his thesis of an unimpeachable human capacity for reasoning is not a defense of human reasoning, but rather amounts to the claim that (...) we cannot make any meaningful evaluative claims about human reasoning whatsoever. (shrink)

Name der Zeitschrift: Archiv für Geschichte der Philosophie Jahrgang: 98 Heft: 2 Seiten: 169-192.

- Poétique et Études littéraires – GALERIE – Nouvel article.

Book reviewed in this article: Madness and the Criminal Law. By Norval Morris. The Insanity Plea: The Uses and Abuses of the Insanity Defense. By William J. Winslade and Judith Wilson Ross.

Dilthey’s moral writings have received scant attention over the years, perhaps due to his apparent tendency toward relativism. This essay offers a unified look at Dilthey’s moral writings in the context of his Kantian-styled “Critique of Historical Reason.” I present the Dilthey of the moral writings as an observer of reason in the spirit of Kant, watching practical reason devolve into error when it applies itself beyond the bounds of possible experience. Drawing on moral writings from across Dilthey’s corpus, I (...) retrace Dilthey’s argument that moral theories from Kantianism and utilitarianism to natural law theory suffer significant motivational problems because of the way they transcend the “synthesis” of moral perception. Dilthey’s argument suggests that abstract moral theory is always bound to seem unmotivating and unreal from the standpoint of lived experience, and perhaps that, to avoid this, moral philosophy should confine itself to more situated, case-specific judgments. (shrink)

For more than thirty-five years, Zurick has explored, studied, and written about the Himalaya. In this, his third book on the region, he provides a richly rewarding guide to its physical features, its myriad cultures, and the impact that urbanization, climate change, and tourism hold for the region's future. --.

(1997). What Descartes really told Elisabeth: Mind‐body union as a primitive notion. British Journal for the History of Philosophy: Vol. 5, No. 2, pp. 249-273. doi: 10.1080/09608789708570966.

This article, originally presented as a keynote address at the 2019 McCain conference, proposes that we must take seriously the “moral” component of moral injury. In addition to psychological treatment, wounded warriors suffering moral injury require atonement for genuine transgressions, and insight when the conduct they regard as transgression actually is not. The article defines the dimensions of moral injury as parallel to those of physical injury: pain, loss of functionality, and (in some cases) disfigurement. It then asks how atonement (...) can be achieved, turning to an unusual source for inspiration: the laws of atonement set out by the medieval Jewish philosopher Moses Maimonides. Maimonides proposes four requirements: verbal confession, repentance, reparation, and apology. The article explains their meaning in the context of contemporary wounded warriors. Finally, it argues that Judaism’s unique tradition of collective atonement offers an important model for the armed services. (shrink)

In this paper, I investigate the role played by Quality of Will in Michael McKenna’s conversational theory of responsibility. I articulate and press the skeptical challenge against it, and then I show that McKenna has the resources in his account to deflect it.

In a ground-breaking essay Nagel contended that the controversy over impossible numbers influenced the development of modern logic. I maintain that Nagel was correct in outline only. He overlooked the fact that the controversy engendered a new account of reasoning, one in which the concept of a well-made language played a decisive role. Focusing on the new account of reasoning changes the story considerably and reveals important but unnoticed similarities between the development of algebraic logic and quantificational logic.

Longing is a universal human experience, born of the inevitable gulf between dream and reality, what we need and what we have. While the experience of longing may arise from loss or the awareness of a void in one’s life, it may also become a powerful engine of spiritual growth, prompting one to draw closer to the hidden yet present “Other.” Across the range of Jewish teachings, longing takes center stage in one’s spiritual life. From the Bible through current frontiers (...) in Jewish belief and practice, God is both known and unknown, immediate and remote, present and in constant eclipse. This book captures the sense of longing in Jewish tradition by creating a dialogue between the author’s own struggles with an estranged father and a wide range of traditional and contemporary sources. Focusing on the story of the Hebrew prophet Elisha, the book takes the reader through a journey of abandonment, creative destruction, and ultimately repair and healing, engaging with currents in biblical theology, rabbinic thought, Kabbalah, and contemporary Jewish philosophy. Written in a familiar yet probing style, this book is an accessible introduction to Jewish thought and spirituality as well as a thoughtful companion for more experienced students. (shrink)

Philosophies of essence provides a critical evaluation of the concept of 'essence' from the Pre-Socratics to the present, as well as indicating the social roots of the various developments. Further, it shows the fruitfulness the concept still has for a scientific materialistic outlook. In addition, a new dual formulation of the concept is given.--Preface.

This chapter argues that ethics plays an extremely important role in decision making and lawmaking in bioethics issues. These decisions are not simple case-by-case judgments; rather, they rest upon deeply considered ethical opinions. It also discusses the implications of this epistemic grounding for bioethics and its use of case law materials as an ethical resource. Finally, since many people base their moral judgments on religious beliefs, the religious implications of this legal-moral relationship are considered.