From stem cells to oocyte, Drosophila germ cells undergo a short, defined lineage. Molecular genetic analyses of a collection of female sterile mutations have indicated that a germ cell‐specific organelle called the fusome has a central role at several steps in this lineage. The fusome grows from a prominent spherical organelle to an elongated and branched structure that connects all mitotic sisters in a germ cell syncytium. The organelle is assembled from proteins normally found in the membrane skeleton and, additionally, (...) contains an extensive membranous reticulum, the probable product of differentiation‐dependent vesicle trafficking. This review briefly summarizes a current view of the processes that drive germ cell differentiation, particularly the various roles that the fusome might play in regulating the developmental events. Future efforts will consider to what extent an organelle assembly‐dependent model for differentiation is heuristic and whether the Drosophila fusome represents a homolog of a similar organelle in vertebrate lymphocytes. (shrink)

'Holographic' relations between theories have become a main theme in quantum gravity research. These relations entail that a theory without gravity is equivalent to a gravitational theory with an extra spatial dimension. The idea of holography was first proposed in 1993 by Gerard 't Hooft on the basis of his studies of evaporating black holes. Soon afterwards the holographic 'AdS/CFT' duality was introduced, which since has been heavily studied in the string theory community and beyond. Recently, Erik Verlinde has proposed (...) that even Newton's law of gravitation can be related holographically to the thermodynamics of information on screens. We discuss inter-theoretical relations in these scenarios: what is the status of the holographic relation in them and in what sense is gravity, or spacetime, emergent? (shrink)

The Brooks Range, one of the most remote and least-disturbed wildernesses of North America, is immense and inaccessible enough to earn a nearly mythic reputation. Dennis Witmer’s splendid volume, Far to the North: Photographs from the Brooks Range explores the limits of the tree line that juts through the southern edge of the range, revealing northern peaks and valleys bare of vegetation and glossed over by a softening snow that can arrive at any time of the year. A magnificent (...) glimpse at nature in its most pristine and raw form, the epic photography featured in Far to the North will be a welcome addition to the collection of any explorer or lover of the northern landscape. (shrink)

Refinements in Darwin’s theory of the origin of a moral sense create a framework equipped to organize and integrate contemporary theory and research on morality. Morality originated in deferential, cooperative, and altruistic ‘‘social instincts,’’ or decision-making strategies, that enabled early humans to maximize their gains from social living and resolve their conflicts of interest in adaptive ways. Moral judgments, moral norms, and conscience originated from strategic interactions among members of groups who experienced confluences and conflicts of interest. Moral argumentation buttressed (...) by moral reasoning is equipped to generate universal and impartial moral standards. Moral beliefs and standards are products of automatic and controlled information-processing and decision making mechanisms. To understand how people make moral decisions, we must understand how early evolved mechanisms in the old brain and recently evolved mechanisms in the new brain are activated and how they interact. Understanding what a sense of morality is for helps us understand what it is. (shrink)

This study investigates the market reaction to corporate press releases announcing donations to the relief effort following the December, 2004 tsunami in Southeast Asia. Based on a sample of 79 U.S. companies, results indicate a statistically significant positive 5-day cumulative abnormal return. While differences in the timing of the press releases do not appear to have influenced market reactions, the amount of the donations did. Overall, the results appear to support Godfrey’s (Academy of Management Review 30, 777–798; 2005) assertion that (...) philanthropic giving must be perceived as being a genuine manifestation of the firm’s underlying social responsiveness in order to increase firm value. (shrink)

Experimental evidence of the last decades has made the status of ``collapses of the wave function'' even more shaky than it already was on conceptual grounds: interference effects turn out to be detectable even when collapses are typically expected to occur. Non-collapse interpretations should consequently be taken seriously. In this paper we argue that such interpretations suggest a perspectivalism according to which quantum objects are not characterized by monadic properties, but by relations to other systems. Accordingly, physical systems may possess (...) different properties with respect to different ``reference systems''. We discuss some of the relevant arguments, and argue that perspectivalism both evades recent arguments that single-world interpretations are inconsistent and eliminates the need for a privileged rest frame in the relativistic case. (shrink)

Abstract:Recent developments in personality research point to an alchemy of character composed of five elements: extroversion, agreeableness, conscientiousness, neuroticism, and openness to experience. This paper surveys this research for its implications to the study of the virtues in organizational ethics. After subjecting each of these five character traits to several tests as to what constitutes a virtue, the empirical evidence supports an organizational virtue of agreeableness and an organizational virtue of conscientiousness. Although the empirical evidence falls short, an argument is (...) mobilized on behalf of an additional organizational virtue of openness to experience. (shrink)

Saunders has recently claimed that “identical quantum particles” with an anti-symmetric state (fermions) are weakly discernible objects, just like irreflexively related ordinary objects in situations with perfect symmetry (Black’s spheres, for example). Weakly discernible objects have all their qualitative properties in common but nevertheless differ from each other by virtue of (a generalized version of) Leibniz’s principle, since they stand in relations an entity cannot have to itself. This notion of weak discernibility has been criticized as question begging, but we (...) defend and accept it for classical cases likes Black’s spheres. We argue, however, that the quantum mechanical case is different. Here the application of the notion of weak discernibility indeed is question begging and in conflict with standard interpretational ideas. We conclude that the introduction of the conceptual resource of weak discernibility does not change the interpretational status quo in quantum mechanics. (shrink)

A natural heme deficiency that exists in cells outside of the circulation broadly compromises the heme contents and functions of heme proteins in cells and tissues. Recently, we found that the signaling molecule, nitric oxide (NO), can trigger or repress the deployment of intracellular heme in a concentration‐dependent hormetic manner. This uncovers a new role for NO and sets the stage for it to shape numerous biological processes by controlling heme deployment and consequent heme protein functions in biology.

Weiss, Propen, and Reid gather a diverse group of scholars to analyze the growing obsolescence of the human-object dichotomy in today's world. In doing so, Design, Mediation, and the Posthuman brings together diverse disciplines to foster a dialog on significant technological issues pertinent to philosophy, rhetoric, aesthetics, and science.

This essay examines Don Ihde’s postphenomological philosophy of technology through the lens of philosophical anthropology, that sub-discipline of philosophy concerned with the nature and place of the human being. While Ihde’s philosophical corpus and its reception in Postphenomenology: A Critical Companion to Ihde indicate rich resources for thinking about human nature, several themes receive too little attention in both, including the nature of the human being, the emergence of the posthuman, and the place of the human being in our contemporary (...) pluriculture. (shrink)

I began teaching business ethics over 20 years ago in the hope that I would be out of business in 10 years. Scandals and poor decision making have only continued, most recently with the financial crisis of 2008. The context for ethics and morality is decision making. Those who teach business ethics in this challenging century will be well served to consider the purpose and pedagogy of ethics in a business curriculum. I assess and discuss the purpose of business ethics (...) in a business curriculum. I argue that business ethics education can be conceived as strengthening skills for making good decisions. I relate this to the Greek conception of practical wisdom (“phronesis”). I propose a method for achieving this purpose, based on a flight simulation model, a method that hassignificantly reduced pilot error caused accidents. The characteristics of this program are decision making practice, exhaustive debriefing, and creating an environment for engaging diverse perspectives on problems and solutions. (shrink)

Robert Nozick has suggested that risky actions are a problem for a moral view based on rights. We ordinarily think that some actions are too dangerous to be permissible, taking into account both the harm risked and the degree of the risk. Other actions, although they run some risk of serious harm, are thought permissible. The problem is to draw this distinction in a principled way by looking to rights.I think that Nozick's argument about risk can be answered but a (...) different argument has convinced me that the rights view cannot handle risk in a satisfactory way. The inability is a function of the basic nature of the view. (shrink)

In a recent comment on H.L.A. Hart’s ‘Postscript’ to The Concept of Law, Ronald Dworkin claims that the meaning of legal and political concepts may be understood by analogy to the meaning of natural kind concepts like ‘tiger’, ‘gold’ and ‘water’. This article questions the efficacy of Dworkin’s claims by challenging the use of natural kinds as the basis for a semantic theory of legal and political concepts. Additionally, in matters of value there is no methodological equivalent to the scientific (...) method. Thus, there is little hope of finding hidden essences to explain the meaning of legal and political concepts. Finally, even if there are natural kinds, Dworkin’s arguments for their efficacy in jurisprudence are problematic and unpersuasive. The problem for Dworkin is that his embrace of natural kinds undermines the ‘fit’ side of the fit/justification model of adjudication that lies at the heart of his theory of law. (shrink)

Concern about the integrity of empirical research has arisen in recent years in the light of studies showing the vast majority of publications in academic journals report positive results, many of these results are false and cannot be replicated, and many positive results are the product of data dredging and the application of flexible data analysis practices coupled with selective reporting. While a number of potential solutions have been proposed, the effects of these are poorly understood and empirical evaluation of (...) each would take many years. We propose that methods from the systems sciences be used to assess the effects, both positive and negative, of proposed solutions to the problem of declining research integrity such as study registration, Registered Reports, and open access to methods and data. In order to illustrate the potential application of systems science methods to the study of research integrity, we describe three broad types of models: one built on the characteristics of specific academic disciplines; one a diffusion of research norms model conceptualizing researchers as susceptible, “infected” and recovered; and one conceptualizing publications as a product produced by an industry comprised of academics who respond to incentives and disincentives. (shrink)

It is argued that the symmetry and anti-symmetry of the wave functions of systems consisting of identical particles have nothing to do with the observational indistinguishability of these particles. Rather, a much stronger conceptual indistinguishability is at the bottom of the symmetry requirements. This can be used to argue further, in analogy to old arguments of De Broglie and Schrödinger, that the reality described by quantum mechanics has a wave-like rather than particle-like structure. The question of whether quantum statistics alone (...) can give rise to empirically observable correlations between results of distant measurements is also discussed. (shrink)

Ethical analyses of the relations between managers and subordinates have traditionally focused on the employment contract. The inequality and requisite mutual trust between managers and subordinates makes the sub-disciplines of professional ethics and feminist ethics more applicable than the contractarian perspective. When professional ethics is applied to hierarchic relationships, specific obligations emerge for managers and subordinates alike. The application of feminist ethics results in the identification of an entirely different, though not contradictory, set of obligations. In toto, the analysis improves (...) on the conventional wisdom governing hierarchic relationships while at the same time remaining consistent with our moral intuitions. (shrink)

The significance of A. N. Whitehead’s contribution to 20th century metaphysics has become widely recognized. The focus on the novelty of his process ontology, however, has led to a view that isolates him from the mainstream of the tradition of Western philosophy. Hence, it is often overlooked that on the methodological level Whitehead is a pragmatist, whose much quoted indebtedness to William James is reflected in the project of his speculative metaphysics. A detailed analysis of the respective theories of truth (...) and knowledge in James and Whitehead illustrates their common methodological approach and allows us to assess the role of Whiteheadian thinking within the pragmatist tradition. James advances a form of epistemic conservatism that supplements the pragmatic idea of a concept’s cash-value with the demand for internal consistency. New beliefs have to fit in the totality of all previously accepted convictions in order to become accepted as true. James argues his case on three levels – a psychological, an epistemological and a pragmatic one – and develops a theory of truth that comprises an empirical and a rational dimension. Whitehead takes up this two-sided approach, but modifies the idea of genetic consistency into that of systematic coherence. The fundamental concepts of an ontological theory must not be isolated from each other to allow for a cosmology which is both rational and satisfies the pragmatic test of applicability. With the close relation of James and Whitehead in mind, the latter can be identified as the ‘missing link’ that bridges the gap between the so-called classical pragmatism and its more analytic versions as advanced by Quine, Lewis and Rescher. (shrink)

In his general theory of relativity Einstein sought to generalize the special-relativistic equivalence of inertial frames to a principle according to which all frames of reference are equivalent. He claimed to have achieved this aim through the general covariance of the equations of GR. There is broad consensus among philosophers of relativity that Einstein was mistaken in this. That equations can be made to look the same in different frames certainly does not imply in general that such frames are physically (...) equivalent. We shall argue, however, that Einstein's position is tenable. The equivalence of arbitrary frames in GR should not be equated with relativity of arbitrary motion, though. There certainly are observable differences between reference frames in GR. The core of our defense of Einstein's position will be to argue that such differences should be seen as fact-like rather than law-like in GR. By contrast, in classical mechanics and in special relativity the differences between inertial systems and accelerated systems have a law-like status. The fact-like character of the differences between frames in GR justifies regarding them as equivalent in the same sense as inertial frames in SR. (shrink)

The problem of divine agency and action is analogous to the problem of human agency and action: How is such agency possible in the absence of a dualistic causal interaction between disparate orders of being? This paper explores nondualistic accounts of divine agency that assert the following: (1) physical monism, (2) antireductionism, (3) physical realization, and (4) divine causal realism. I conclude that a robustly causal deity is incompatible with nonddualism's affirmation of physical monism. Specifically, I argue the incoherence of (...) nondualistic strategies that advocate divine information transfer without energy transfer or the divine downward causation of physical events. Furthermore, I claim that the principle of explanatory exclusion makes any nondualistic, noninterventionist account of divine agency highly dubious. Finally, I suggest that Judaism, Christianity, and Islam can avoid a causally inert deity only if they are willing to deny the current presumption of the causal closure of the physical. (shrink)

Zygmunt Bauman has used his `outsider' position to explore the defining boundaries of our world and help shape a discourse which allows communication across these boundaries. In this spirit he has investigated: sociology and culture; capitalism, socialism and class; and modernity and postmodernity. Bauman has argued for an emancipatory sociology which takes full account of what ought and ought not to be, what human beings hope for and fear, and the need to give people intellectual tools to make use of (...) their freedom. Applying the strategy of the `hermeneutic circle', he has examined capitalist and socialist regimes from a range of vantage points. He has also identified the challenges we all now face as inhabitants of the half-ruined structures created by modernity's failed ambitions. Bauman has confronted these challenges in the last decade by focusing on the evils of modern bureaucracy as epitomized by the Holocaust, the inescapability of each individual's responsibility for his or her own moral choices, and the potential for an open and self-critical dialogue between sociologists and their fellow citizens. (shrink)

The egalitarian values of equality and priority are standardly given maximal scope in that they are applied to the overall condition of peoples' lives and to temporally complete lifetimes. They are also standardly restricted to interpersonal choices. This paper argues that egalitarian values can also reasonably be applied to particular dimensions of lives, to people at particular times, and to choices made about one person's life. It contends that these special applications of egalitarianism are easier to defend in the case (...) of priority than in the case of equality. (shrink)

Timothy Williamson has a marvelously precise account of epistemic justification in terms of knowledge and probability. I argue that the account runs aground on certain cases involving the probability values 0 and 1.

Sometimes we make decisions which affect our lives at times when we will hold values that are different from our values at the time the decision is made. What is the reasonable way to make such a choice? Some think we should accept a requirement of temporal neutrality and take both sets of values into account, others think we should decide on the strength of our present values, yet others think that in evaluating what will happen at that other time (...) we should use the values that we will endorse at that time instead of our present values. These views see the problem as one about finding some attitude towards time itself that is distinctively rational. This article argues that these views are subject to serious objections. It suggests that instead we should think in terms of well-being. If a person approves of, or positively responds to, the way their life is going they will experience more well-being than if there is no positive response. The article explores the implications of a positive response condition on well-being for deciding what it is rational to do in cases involving changing goals. (shrink)

As interpreted by Pattee, von Neumann’s Theory of Self-Reproducing Automata has proved to be a useful tool for understanding some of the difficulties and paradoxes of molecular biosemiotics. But is its utility limited to molecular systems or is it more generally applicable within biosemiotics? One way of answering that question is to look at the Theory as a model for one particular high-level biosemiotic activity, human language. If the model is not useful for language, then it certainly cannot be generally (...) useful to biosemiotics. Beginning with the Universal Turing Machine and continuing with von Neumann’s Theory and Pattee’s interpretation, the properties of universality, programmability, underspecification, complementarity of description/construction, and open-ended evolutionary potential are shown to be usefully applicable to language, thus opening a new line of inquiry in biosemiotics. (shrink)

The COVID-19 pandemic has catalysed what may soon become a permanent digital transition in the domains of work, education, medicine, and leisure. This transition has also precipitated a spike in concern regarding our digital well-being. Prominent lobbying groups, such as the Center for Humane Technology, have responded to this concern. In April 2020, the CHT has offered a set of ‘Digital Well-Being Guidelines during the COVID-19 Pandemic.’ These guidelines offer a rule-based approach to digital well-being, one which aims to mitigate (...) the effects of moving much of our lives online. The CHT’s guidelines follow much recent interest in digital well-being in the last decade. Ethicists of technology have recently argued that character-based strategies and redesigning of online architecture have the potential to promote the digital well-being of online technology users. In this article, I evaluate the CHT’s rule-based approach, comparing it with character-based strategies and approaches to redesigning online architecture. I argue that all these approaches have some merit, but that each needs to contribute to an integrated approach to digital well-being in order to surmount the challenges of a post-COVID world in which we may well spend much of our lives online. (shrink)

This Perspective traces the evolution of certain central notions in the theory of Generative Grammar (GG). The founding documents of the field suggested a relation between the grammar, construed as recursively enumerating an infinite set of sentences, and the idealized native speaker that was essentially equivalent to the relation between a formal language (a set of well-formed formulas) and an automaton that recognizes strings as belonging to the language or not. But this early view was later abandoned, when the focus (...) of the field shifted to the grammar's strong generative capacity as recursive generation of hierarchically structured objects as opposed to strings. The grammar is now no longer seen as specifying a set of well-formed expressions and in fact necessarily constructs expressions of any degree of intuitive “acceptability.” The field of GG, however, has not sufficiently acknowledged the significance of this shift in perspective, as evidenced by the fact that (informal and experimentally-controlled) observations about string acceptability continue to be treated as bona fide data and generalizations for the theory of GG. The focus on strong generative capacity, it is argued, requires a new discussion of what constitutes valid empirical evidence for GG beyond observations pertaining to weak generation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Awareness of the Natural World in Shinjin: Shinran's Concept of JinenDennis HirotaAttainment of Shinjin and TruthThe primary issue regarding knowledge that Shinran (1173-1263) treats in his writings concerns the commonplace, "natural" presupposition that it is constituted by an ego-subject relating itself to stable objects in the world. From his stance within Buddhist tradition, Shinran identifies the crucial problem as the human tendency toward the reification of both sides (...) of this dichotomy-resulting in an autonomous self and substantial things-with the consequent attachments fueling the afflictions ("blind passions") of habitual pain and conflict for oneself and others. The focus of Shinran's treatment of this basic Buddhist concern is the point of engagement with dharma or true reality. In this, he draws into the arena of religious faith the probing scrutiny of lingering attachments to self, even in the dedicated practitioner, that is fundamental to the critical attitude of Mahayana Buddhist tradition.My aim in taking up the issue of truth in my article "Shinran and Heidegger on Truth" in The Boundaries of Knowledge in Buddhism, Christianity, and Science 1 is to suggest a way of reading Shinran that both avoids a common pitfall that Shinran himself cautions against-an engagement with Pure Land teachings that adheres to the subject-object dichotomy of ordinary awareness-and opens up his vision to resonances with contemporary western thought, particularly continental philosophy. This latter concern is not to claim that Shinran adumbrates contemporary thought or is affirmed by resemblances, but rather seeks to cast light on compelling aspects of his thought not often treated in traditional Shin scholastics. There are, therefore, both therapeutic and constructive sides in my attempt to engage Martin Heidegger's (1889-1976) thought from a perspective rooted in Shinran's Buddhism.The pitfall in reading Shinran indicated in my article is crystallized in the assumption, prevalent in Western scholarship but also widely seen in Japan, that his Shin Buddhist path centers on a simple faith in the Pure Land teachings, with such faith understood as the subjective acceptance of the truth of doctrinal propositions. In [End Page 189] other words, it is commonly presupposed that Shin Buddhist tradition (what he terms jōdo shinshū, "the true essence of the Pure Land way") implicitly affirms the subject-object dichotomy. This difficulty is frequently compounded by formulations of the supposed tenets of belief that are heavily molded and colored by Protestant Christian notions of self, sin, eschatology, and atonement. It is impossible to take up such comparative theological issues here. 2 In a sense, I have sought in my article to circumvent a hasty assessment of conceptual equivalence by pointing out the possibility of an encompassing or prior dissonance.Since Shinran's concept of "attaining shinjin" (true entrusting, which is also the Buddha-mind given to the practitioner) is built on the endeavor to deconstruct the reification of this dichotomy in engagement with the Pure Land Buddhist path, the unconsciousness reinstatement of it in reading his writings can lead one to a thorough but easily accomplished misconstrual of his thought. My suggestion in my article is that consideration of the analogues in Heidegger's thought can help us see all this. Such comparison also appears to present a relatively untested avenue for Buddhist-Christian conversation, particularly in view of Heidegger's early indebtedness to Luther's "theology of the cross" and the notion of the "alien work of God" as the critical stripping away of attachments to human capacities (destructio in the "Heidelberg Disputation"), and also his approach to Paul's letters to the Thessalonians in The Phenomenology of Religious Life. 3 The keystone in such interreligious conversation remains, however, not simply human fallibility as subject or culpability as agent, but the persistent challenge to the subject-object dichotomy, which may form a locus of refractory difference between the religious traditions.The constructive side of the comparison concerns two general dimensions of Shinran's thought that are highlighted in an approach to his writings that might be called phenomenological. One includes a shift from a reading based on scriptural foundationalism and doctrinal reasoning to a dialogical reading, one attentive to Shinran's effort to... (shrink)