Douglas proposes a new ideal in which values serve an essential function throughout scientific inquiry, but where the role values play is constrained at key points, protecting the integrity and objectivity of science.

In this first modern, critical assessment of the place of mathematics in Berkeley's philosophy and Berkeley's place in the history of mathematics, Douglas M. Jesseph provides a bold reinterpretation of Berkeley's work. Jesseph challenges the prevailing view that Berkeley's mathematical writings are peripheral to his philosophy and argues that mathematics is in fact central to his thought, developing out of his critique of abstraction. Jesseph's argument situates Berkeley's ideas within the larger historical and intellectual context of the Scientific Revolution. (...) Jesseph begins with Berkeley's radical opposition to the received view of mathematics in the philosophy of the late seventeenth and early eighteenth centuries, when mathematics was considered a "science of abstractions." Since this view seriously conflicted with Berkeley's critique of abstract ideas, Jesseph contends that he was forced to come up with a nonabstract philosophy of mathematics. Jesseph examines Berkeley's unique treatments of geometry and arithmetic and his famous critique of the calculus in The Analyst. By putting Berkeley's mathematical writings in the perspective of his larger philosophical project and examining their impact on eighteenth-century British mathematics, Jesseph makes a major contribution to philosophy and to the history and philosophy of science. (shrink)

SUMMARYThis paper discusses the scientific instruments made and used by the microscopist Antony van Leeuwenhoek. The immediate cause of our study was the discovery of an overlooked document from the Delft archive: an inventory of the possessions that were left in 1745 after the death of Leeuwenhoek's daughter Maria. This list sums up which tools and scientific instruments Leeuwenhoek possessed at the end of his life, including his famous microscopes. This information, combined with the results of earlier historical research, gives (...) us new insights about the way Leeuwenhoek began his lens grinding and how eventually he made his best lenses. It also teaches us more about Leeuwenhoek's work as a surveyor and a wine gauger.A further investigation of the 1747 sale of Leeuwenhoek's 531 single lens microscopes has not only led us to the identification of nearly all buyers, but also has provided us with some explanation about why only a dozen of this large number of microscopes has survived. (shrink)

A growing interest in and concern about the adequacy and fairness of modern peer-review practices in publication and funding are apparent across a wide range of scientific disciplines. Although questions about reliability, accountability, reviewer bias, and competence have been raised, there has been very little direct research on these variables.The present investigation was an attempt to study the peer-review process directly, in the natural setting of actual journal referee evaluations of submitted manuscripts. As test materials we selected 12 already published (...) research articles by investigators from prestigious and highly productive American psychology departments, one article from each of 12 highly regarded and widely read American psychology journals with high rejection rates (80%) and nonblind refereeing practices.With fictitious names and institutions substituted for the original ones (e.g., Tri-Valley Center for Human Potential), the altered manuscripts were formally resubmitted to the journals that had originally refereed and published them 18 to 32 months earlier. Of the sample of 38 editors and reviewers, only three (8%) detected the resubmissions. This result allowed nine of the 12 articles to continue through the review process to receive an actual evaluation: eight of the nine were rejected. Sixteen of the 18 referees (89%) recommended against publication and the editors concurred. The grounds for rejection were in many cases described as “serious methodological flaws.” A number of possible interpretations of these data are reviewed and evaluated. (shrink)

The multiplicity of deubiquitinating enzymes (DUBs) encoded by vertebrate genomes is partly attributable to whole genome duplication events that occurred early in chordate evolution. By surveying the literature for the largest family of DUBs (the ubiquitin-specific proteases), extensive functional redundancy for duplicated genes has been confirmed as opposed to singletons. Dramatically conflicting results have been reported for loss of function studies conducted through RNA interference as opposed to inactivating mutations, but the contradictory findings can be reconciled by a recently proposed (...) compensatory mechanism involving nonsense-mediated RNA degradation. Duplicated genes are often inactivated to become pseudogenes, and it is proposed that such is the fate of the USP15 gene of zebrafish, a commonly used model system. As it is reviewed here, these observations have implications not only for the interpretation of model system phenotypes but also for therapeutic interventions designed to target DUBs. (shrink)

Chapter INTRODUCTION Charles Sanders Peirce is quickly becoming the dominant figure in the history of American philosophy. The breadth and depth of his work ...

In order to improve our understanding of the components that reflect functionally important processes during reward anticipation and consumption, we used principle components analyses (PCA) to separate and quantify averaged ERP data obtained from each stage of a modified monetary incentive delay (MID) task. Although a small number of recent ERP studies have reported that reward and loss cues potentiate ERPs during anticipation, action preparation, and consummatory stages of reward processing, these findings are inconsistent due to temporal and spatial overlap (...) between the relevant electrophysiological components. Our results show three components following cue presentation are sensitive to incentive cues (N1, P3a, P3b). In contrast to previous research, reward‐related enhancement occurred only in the P3b, with earlier components more sensitive to break‐even and loss cues. During feedback anticipation, we observed a lateralized centroparietal negativity that was sensitive to response hand but not cue type. We also show that use of PCA on ERPs reflecting reward consumption successfully separates the reward positivity from the independently modulated feedback‐P3. Last, we observe for the first time a new reward consumption component: a late negativity distributed over the left frontal pole. This component appears to be sensitive to response hand, especially in the context of monetary gain. These results illustrate that the time course and sensitivities of electrophysiological activity that follows incentive cues do not follow a simple heuristic in which reward incentive cues produce enhanced activity at all stages and substages. (shrink)

with Thomas F. Gordon and Henry Prakken. Artificial Intelligence, forthcoming. [Preprint posted.].

This volume collects 17 of Douglas Husak's influential essays in criminal law theory. The essays span Husak's original and provocative contributions to the central topics in the field, including the grounds of criminal liability, relative culpability, the role of defences, and the justification of punishment. The volume includes an extended introduction by the author, drawing together the themes of his work, and exploring the goals of criminal theory.

In the 1950s–60s biochemists searched intensively for a series of high-energy molecules in the cell. Although we now believe that these molecules do not exist, biochemists claimed to have isolated or identified them on at least sixteen occasions. The episode parallels the familiar eighteenth-century case of phlogiston, in illustrating how error is not simply the loss of facts but, instead, must be actively constructed. In addition, the debates surrounding each case demonstrate how revolutionary-scale disagreement is sometimes resolved by differentiating or (...) partitioning empirical domains, rather than by replacement of one theory by another. (shrink)

PrefaceList of AbbreviationsChapter One: The Mathematical Career of the Monster of MalmesburyChapter Two: The Reform of Mathematics and of the UniversitiesIdeological Origins of the DisputeChapter Three: De Corpore and the Mathematics of MaterialismChapter Four: Disputed FoundationsHobbes vs. Wallis on the Philosophy of MathematicsChapter Five: The "Modern Analytics" and the Nature of DemonstrationChapter Six: The Demise of Hobbesian GeometryChapter Seven: The Religion, Rhetoric, and Politics of Mr. Hobbes and Dr. WallisChapter Eight: Persistence in ErrorWhy Was Hobbes So Resolutely Wrong?Appendix: Selections from (...) Hobbes's Mathematical WritingsReferencesIndex Copyright © Libri GmbH. All rights reserved. (shrink)

This important book was the first serious work of philosophy to address the question: Do adults have a moral right to use drugs for recreational purposes? Many critics of the 'war on drugs' denounce law enforcement as counterproductive and ineffective. Douglas Husak argues that the 'war on drugs' violates the moral rights of adults who want to use drugs for pleasure, and that criminal laws against such use are incompatible with moral rights. This is not a polemical tract but (...) a scrupulously argued work of philosophy that takes full account of all available data concerning drug use in the United States today. The author is careful to describe the properties a recreational drug would have to possess before the state would be justified in prohibiting it. Since criminal laws against the use of recreational drugs are justified neither by the harm users cause to themselves nor by the harm users cause to each other, Professor Husak concludes that such laws are, in almost all cases, unjustified. (shrink)

In some recent cases in Anglo-American law juries ruled contrary to an expert's testimony even though that testimony was never challenged, contradicted or questioned in the trial. These cases are shown to raise some theoretical questions about formal dialogue systems in computational dialectical systems for legal argumentation of the kind recently surveyed by Bench-Capon (1997) and Hage (2000) in this journal. In such systems, there is a burden of proof, meaning that if the respondent questions an argument, the proponent is (...) obliged to offer some support for it give it up. But what should happen in a formal system of dialogue if the proponent puts forward an argument and the respondent fails to critically question it, and simply moves on to another issue? Is this some kind of fault that should have implications? Should it be taken to imply that, by default, the respondent has conceded the argument? What, if anything, should be the outcome of such a failure to question in a formal dialogue system of argumentation? These questions are considered by examining some legal cases of expert opinion testimony in relation rules for formal dialectical argumentation systems. (shrink)

This article evaluates the strengths and weaknesses of arguments based on appeals to expertise. The intersection of two areas is explored: (i) the traditional argumentum ad verecundiam (literally, “appeal to modesty,” but characteristically the appeal to the authority of expert judgment) in informal logic, and (ii) the uses of expert systems in artificial intelligence. The article identifies a model of practical reasoning that underlies the logic of expert systems and the model of argument appropriate for the informal logic of the (...) argumentum ad verecundiam. (shrink)

We describe here an interdisciplinary lab science course for non-majors using the history of science as a curricular guide. Our experience with diverse instructors underscores the importance of the teachers and classroom dynamics, beyond the curriculum. Moreover, the institutional political context is central: are courses for non-majors valued and is support given to instructors to innovate? Two sample projects are profiled.

Journal of Applied Logic, to appear [uncorrected version posted].

I highlight a category of experiment-what I am calling 'demonstrations'-that differs in justificatory mode and argumentative role from the more familiar 'crucial tests'. 'Tests' are constructed such that alternative results are equally and symmetrically informative; they help discriminate between alternative solutions within a problem-field, where questions are shared. 'Demonstrations' are notably asymmetrical (for example, "failures" are often not telling), yet they are effective, if not "crucial," in interparadigm dispute, to legitimate questions themselves. The Ox-Phos Controversy in bioenergetics serves as an (...) integral case study. (shrink)

Explanation-Aware Computing: Papers from the 2007 AAAI Workshop, Association for the Advancement of Artificial Intelligence, Technical Report WS-07-06, Menlo Park California, AAAI Press, 2007, 1-9.

Dialogue theory, although it has ancient roots, was put forward in the 1970s in logic as astructure that can be useful for helping to evaluate argumentation and informal fallacies.Recently, however, it has been taken up as a broader subject of investigation in computerscience. This paper surveys both the historical and philosophical background of dialoguetheory and the latest research initiatives on dialogue theory in computer science. The main components of dialogue theory are briefly explained. Included is a classification of the main (...) types of dialogue that, it is argued, should provide the central focus for studying many important dialogue contexts in specific cases. Following these three surveys, a concluding prediction is made about the direction dialogue theory is likely to take in the next century, especially in relation to the growing field of communication studies. (shrink)

We describe an error type that we call the naturalizing error: an appeal to nature as a self-justified description dictating or limiting our choices in moral, economic, political, and other social contexts. Normative cultural perspectives may be subtly and subconsciously inscribed into purportedly objective descriptions of nature, often with the apparent warrant and authority of science, yet not be fully warranted by a systematic or complete consideration of the evidence. Cognitive processes may contribute further to a failure to notice the (...) lapses in scientific reasoning and justificatory warrant. By articulating this error type at a general level, we hope to raise awareness of this pervasive error type and to facilitate critiques of claims that appeal to what is “natural” as inevitable or unchangeable. (shrink)

On Metz's view, the best interpretation of ubuntu is that it enjoins agents always to promote harmony in the community. However, while I endorse the claim that intuitions play a foundational role in moral thinking, I am less sanguine about two aspects of Metz's particular employment of the intuitions he focuses on. First, I doubt the intuitions from which he begins are of the right sort to play the role he would like them to play. Second, I doubt that the (...) explanation that Metz provides for these foundational intuitions is likely to succeed. One might helpfully characterise the nature of my difference with Metz in terms of the thought that Metz's explanation of the way in which intuitions are to be made to cohere is too Kantian for my taste. In this paper, I draw attention to some structural features of Metz's employments of pro tanto intuitions before sketching an alternative approach to the understanding of such intuitions and applying some aspects of this alternative approach to our thinking about African moral philosophy. The result presents a rival that I hope will appear more attractive than Metz's own. South African Journal of Philosophy Vol. 26 2007: pp. 356-363. (shrink)

Credibility in a scientific community (sensu Shapin) is a vicarious selector (sensu Campbell) for the reliability of reports by individual scientists or institutions. Similarly, images from a microscope (sensu Hacking) are vicarious selectors for studying specimens. Working at different levels, the process of indirect reasoning and checking indicates a unity to experimentalist and sociological perspectives, along with a resonance of strategies for assessing reliability. The perspective sketched here can open dialogue between philosophical and sociological interpretations of science and resolves at (...) least one tension regarding the "primary" factors by which scientists evaluate claims. (shrink)

This chapter is concerned with the foundations of Hobbes’s natural philosophy, notably his account of space and time, as well as an inertial law the author terms the “persistence principle” and a mechanistic principle of action by contact. The author argues that these foundational concepts and principles serve as a framework that places constraints upon the kinds of hypotheses that may figure in the explanation of phenomena, but they do not uniquely determine how natural philosophy is to be developed. In (...) particular, the author shows that Hobbes took questions about the infinitude and uniqueness of the world as unanswerable in principle, although he regarded the question of the vacuum as an empirical matter that could be settled by experiment. Hobbes did, however, hold that certain doctrines were incoherent and should be rejected on a priori grounds. (shrink)

International Commentary on Evidence, 2006 Vol. 4, Issue 2, 1-47 . [link to online version posted].

Studies in Communication Sciences, 6, 2006, 3-26 . [link to online version posted].