BackgroundBiobanks are considered to be key infrastructures for research development and have generated a lot of debate about their ethical, legal and social implications. While the focus has been on human genomic research, rapid advances in human microbiome research further complicate the debate.DiscussionWe draw on two cystic fibrosis biobanks in Toronto, Canada, to illustrate our points. The biobanks have been established to facilitate sample and data sharing for research into the link between disease progression and microbial dynamics in the lungs (...) of pediatric and adult patients. We begin by providing an overview of some of the ELSI associated with human microbiome research, particularly on the implications for the broader society. We then discuss ethical considerations regarding the identifiability of samples biobanked for human microbiome research, and examine the issue of return of results and incidental findings. We argue that, for the purposes of research ethics oversight, human microbiome research samples should be treated with the same privacy considerations as human tissues samples. We also suggest that returning individual microbiome-related findings could provide a powerful clinical tool for care management, but highlight the need for a more grounded understanding of contextual factors that may be unique to human microbiome research.ConclusionsWe revisit the ELSI of biobanking and consider the impact that human microbiome research might have. Our discussion focuses on identifiability of human microbiome research samples, and return of research results and incidental findings for clinical management. (shrink)

Gareth Matthews suggests that we can better understand the nature of philosophical inquiry if we recognize the central role played by perplexity. The seminal representation of philosophical perplexity is in Plato's dialogues; Matthews examines the intriguing shifts in Plato's attitude to perplexity and suggests that these may represent a course of philosophical development that philosophers follow even today.

We report on an interview-based study of decision-making capacity in two classes of patients suffering from depression. Developing a method of second-person hermeneutic phenomenology, we articulate the distinctive combination of temporal agility and temporal inability characteristic of the experience of severely depressed patients. We argue that a cluster of decision-specific temporal abilities is a critical element of decision-making capacity, and we show that loss of these abilities is a risk factor distinguishing severely depressed patients from mildly/moderately depressed patients. We explore (...) the legal and clinical consequences of this result. (shrink)

This paper investigates the difficulties of creating economic, social, and environmental values when operating as a hybrid venture. Drawing on hybrid organizing and sustainable business model research, it explores the implications of alternative forms of business model experimented with by farmer owned, fairtrade social enterprise Cafédirect. Responding to changes and challenges in the market and societal environment, Cafédirect has tried multiple business model innovations to deliver on all three forms of value capture, with differing levels of success. This longitudinal case (...) study, therefore, provides a contribution to our understanding of how business models enact hybrid mission, providing a platform for triple-bottom-line value capture. In doing so, we are able to expand on the normative understandings of integrating hybrid objectives, and the complications of multiple types of value capture. (shrink)

Revision of author's thesis (Ph. D.)--University of Oxford, 2012 under title Moral theological method in the theological ethics of Martin Luther and Arthur Rich, with particular reference to their economic ethics.

In a recent paper, Jc Beall has employed what he calls ‘shriek rules’ in a putative solution to the long-standing ‘just false’ problem for glut theory. The purpose of this paper is twofold: firstly, I distinguish the ‘just false’ problem from another problem, with which it is often conflated, which I will call the ‘exclusion problem’. Secondly, I argue that shriek rules do not help glut theorists with either problem.

With the waves of reform occurring in mental health legislation in England and other jurisdictions, mental capacity is set to become a key medico-legal concept. The concept is central to the law of informed consent and is closely aligned to the philosophical concept of autonomy. It is also closely related to mental disorder. This paper explores the interdisciplinary terrain where mental capacity is located. Our aim is to identify core dilemmas and to suggest pathways for future interdisciplinary research. The terrain (...) can be separated into three types of discussion: philosophical, legal and psychiatric. Each discussion approaches mental capacity and judgmental autonomy from a different perspective yet each discussion struggles over two key dilemmas: whether mental capacity and autonomy is/should be a moral or a psychological notion and whether rationality is the key constitutive factor. We suggest that further theoretical work will have to be interdisciplinary and that this work offers an opportunity for the law to enrich its interpretation of mental capacity, for psychiatry to clarify the normative elements latent in its concepts and for philosophy to advance understanding of autonomy through the study of decisional dysfunction. The new pressures on medical and legal practice to be more explicit about mental capacity make this work a priority. (shrink)

This volume collects thirteen papers by one of the leading philosophers of his generation, who died prematurely in 1980.

Theoria, EarlyView. -/- In his recent book Thin Objects, Øystein Linnebo (2018) argues for the existence of a hierarchy of abstract objects, sufficient to model ZFC, via a novel and highly interesting argument that relies on a process called dynamic abstraction. This paper presents a way for a nominalist, someone opposed to the existence of abstract objects, to avoid Linnebo's conclusion by rejecting his claim that certain abstraction principles are sufficient for reference (RBA). Section 1 of the paper explains Linnebo's (...) argument for RBA. It offers a reading of Linnebo's work upon which he has two arguments for RBA: one deductive and one abductive, and argues that whilst the deductive argument is unsound the abductive one is prima facie plausible. The nominalist must therefore find a way to respond to the abductive argument. Section 2 outlines just such a response, by offering an alternative explanation of the cases Linnebo wishes to argue from. Most interestingly, it shows that abstraction in Linnebo's most difficult case (the “reference to ordinary bodies” case) can be achieved using mereological means, rather than relying on RBA. (shrink)

‘A logical theory may be tested by its capacity for dealing with puzzles, and it is a wholesome plan, in thinking about logic, to stock the mind with as many puzzles as possible, since these serve much the same purpose as is served by experiments in physical science.’ This paper is an attempt to follow Russell’s advice by using a puzzle about the contingent a priori to test and explore certain theories of reference and modality. No one could claim that (...) the puzzle is of any great philosophical importance by itself, but to understand it, one has to get clear about certain aspects of the theory of reference; and to solve it, one has to think a little more deeply than one is perhaps accustomed about what it means to say that a statement is contingent or necessary. (shrink)

Whom should we credit for the discovery of isotopes? The first suggestion of an idea, the first experimental proof, or the development of a new method that clearly reveals the isotopes? Strömholm and Svedberg, Fajans and Soddy interpreted patterns of radioactive decay, which became confirmed theory on the solid basis of the very accurate atomic weight determinations by Richards and his coworkers. The mass spectrograph measurements by Aston provided major extension of the concept of isotopes to much of the rest (...) of the periodic table. Thus, Strömholm and Svedberg, Fajans and Soddy provided an idea, which Richards proved, and Aston made generally useful. Richards should be listed along with Fajans, Soddy, and Aston for fundamental contributions to establishing isotopes as part of the modern language of science. As much credit should be given to the experimental proof as to the suggestion or naming of the concept. (shrink)

Whom should we credit for the discovery of isotopes? The first suggestion of an idea, the first experimental proof, or the development of a new method that clearly reveals the isotopes? Strömholm and Svedberg, Fajans and Soddy interpreted patterns of radioactive decay, which became confirmed theory on the solid basis of the very accurate atomic weight determinations by Richards and his coworkers. The mass spectrograph measurements by Aston provided major extension of the concept of isotopes to much of the rest (...) of the periodic table. Thus, Strömholm and Svedberg, Fajans and Soddy provided an idea, which Richards proved, and Aston made generally useful. Richards should be listed along with Fajans, Soddy, and Aston for fundamental contributions to establishing isotopes as part of the modern language of science. As much credit should be given to the experimental proof as to the suggestion or naming of the concept. (shrink)

Whom should we credit for the discovery of isotopes? The first suggestion of an idea, the first experimental proof, or the development of a new method that clearly reveals the isotopes? Strömholm and Svedberg, Fajans and Soddy interpreted patterns of radioactive decay, which became confirmed theory on the solid basis of the very accurate atomic weight determinations by Richards and his coworkers. The mass spectrograph measurements by Aston provided major extension of the concept of isotopes to much of the rest (...) of the periodic table. Thus, Strömholm and Svedberg, Fajans and Soddy provided an idea, which Richards proved, and Aston made generally useful. Richards should be listed along with Fajans, Soddy, and Aston for fundamental contributions to establishing isotopes as part of the modern language of science. As much credit should be given to the experimental proof as to the suggestion or naming of the concept. (shrink)

‘A logical theory may be tested by its capacity for dealing with puzzles, and it is a wholesome plan, in thinking about logic, to stock the mind with as many puzzles as possible, since these serve much the same purpose as is served by experiments in physical science.’ This paper is an attempt to follow Russell’s advice by using a puzzle about the contingent a priori to test and explore certain theories of reference and modality. No one could claim that (...) the puzzle is of any great philosophical importance by itself, but to understand it, one has to get clear about certain aspects of the theory of reference; and to solve it, one has to think a little more deeply than one is perhaps accustomed about what it means to say that a statement is contingent or necessary. (shrink)

Much of the literature exploring the intersection between Deleuzo-Guattarian philosophy and architecture have focused on abstract theory, experimental projects and practices at the margins of the profession. But, one may ask, what of the mainstream, commercial practices that produce the offices, housing, shops, schools and community buildings that we see and engage with in our day-to-day lives? What of the everyday design decisions made by professional architects and technicians sitting at their desks and drawing boards? Are these to be excluded (...) from architecture's engagement with Deleuzo-Guattarian philosophy? As I will show in this paper, Deleuze and Guattari's proposals for the strata and the machinic assemblage are drawn from their underlying attempt to expand Hjelmslev's planar composition from a tool used to analyse language to a conceptual framework used to analyse the formation and evolution of all things. There is nothing within the conceptual framework of the strata/machinic assemblage to suggest, therefore, that they should not be used to analyse such practices. With this in mind, this article considers how these concepts can be translated through and help provide new insight into a real-world design sequence taken from mainstream, commercial architectural practice. In doing so it will show how such practices can offer Deleuzo-Guattarian scholars a more nuanced insight into this conceptual framework and the concepts that form it. (shrink)

This paper explores how fair trade social enterprises manage paradoxes in stakeholder-oriented governance models. We use narrative accounts from board members, at governance events and board documents to report an exploratory study of paradoxes in three FTSEs which are partly farmer-owned. Having synthesized the key social enterprise governance literature and framed it alongside the broader paradox theory, we used narratives to explore how tensions are articulated, how they can be applied within an adapted paradox framework, and how governance actors seek (...) to mitigate paradoxes. The paper contributes to current debates in social enterprise scholarship concerning hybridity :455–476, 2010; in Institutional logics in action, Part B, 2012), hybrid organizing :397–441, 2014) and operational tensions :407–442, 2013) by illustrating empirically how the central social/enterprise paradox manifests in FTSEs governance arrangements. We build on the paradox categories proposed by Lüscher and Lewis :221–240, 2008) and adapted in Smith et al. :407–442, 2013) by developing a recursive model of legitimacy-seeking governance processes, conceptualizing how boards seek to mitigate, but not necessarily resolve, paradoxes. (shrink)

Some philosophers, notably Professors Quine and Geach, have stressed the analogies they see between pronouns of the vernacular and the bound variables of quantification theory. Geach, indeed, once maintained that ‘for a philosophical theory of reference, then, it is all one whether we consider bound variables or pronouns of the vernacular'. This slightly overstates Geach's positition since he recognizes that some pronouns of ordinary language do function differently from bound variables; he calls such pronouns ‘pronouns of laziness'. Geach's characterisation of (...) pronouns of laziness has varied from time to time, but the general idea should be clear from a paradigm example: A man who sometimes beats his wife has more sense than one who always gives in to her.The pronouns ‘one’ and ‘her’ go proxy for a noun or a noun phrase in the sense that the pronoun is replaceable in paraphrase by simple repetition of its antecedent. (shrink)

Truth and Meaning is a classic collection of original essays on fundamental questions in the philosophy of language.

Some philosophers, notably Professors Quine and Geach, have stressed the analogies they see between pronouns of the vernacular and the bound variables of quantification theory. Geach, indeed, once maintained that ‘for a philosophical theory of reference, then, it is all one whether we consider bound variables or pronouns of the vernacular'. This slightly overstates Geach's positition since he recognizes that some pronouns of ordinary language do function differently from bound variables; he calls such pronouns ‘pronouns of laziness'. Geach's characterisation of (...) pronouns of laziness has varied from time to time, but the general idea should be clear from a paradigm example: A man who sometimes beats his wife has more sense than one who always gives in to her.The pronouns ‘one’ and ‘her’ go proxy for a noun or a noun phrase in the sense that the pronoun is replaceable in paraphrase by simple repetition of its antecedent. (shrink)

Assessment of decision-making capacity (DMC) can be difficult in acquired brain injury (ABI) particularly with the syndrome of organic personality disorder (OPD) (the “frontal lobe syndrome”). Clinical neuroscience may help but there are challenges translating its constructs to the decision-making abilities considered relevant by law and ethics. An in-depth interview study of DMC in OPD was undertaken. Six patients were purposefully sampled and rich interview data were acquired for scrutiny using interpretative phenomenological analysis. Interview data revealed that awareness of deficit (...) and thinking about psychological states can be present. However, the awareness of deficit may not be “online” and effectively integrated into decision-making. Without this online awareness of deficit the ability to appreciate or use and weigh information in the process of deciding some matters appeared absent. We argue that the decision-making abilities discussed are: (1) necessary for DMC, (2) threatened by ABI, and (3) assessable at interview. Some advice for practically incorporating these abilities within assessments of DMC in patients with OPD is outlined. (shrink)

ABSTRACT Thematic analysis is the most widely used method for analysing qualitative data. Recent debates, highlighting the binary distinctions between reflexive TA grounded within the qualitative paradigm and codebook TA with neo-positivist orientations, have emphasized the existence of numerous tensions that researchers must navigate to produce coherent and rigorous research. This article attempts to resolve some of these tensions through developing an approach to TA underpinned by realist philosophy of science. Focusing on interview data, we propose the use of three (...) types of themes and the use of corresponding validity indicators. Using an illustrative example, we outline the conceptual foundations of a realist approach to TA and present recommendations for conducting it in practice. This approach, we claim, reconciles several existing binaries between distinctive types of TA by incorporating the contributions of both for the development of different types of themes. (shrink)

SUMMARYThe nineteenth-century Orientalist and ethnologist, John Crawfurd, publicly rejected Charles Darwin’s theory of evolution in 1868. Crawfurd was a leading advocate of polygenesis but also a supporter of racial equality. In 1820 he published his History of the Indian Archipelago, where he advocated granting household suffrage to all races in the British colonies. After finishing a career in the East India Company in 1828 he became the foremost expert on South-East Asia in Britain. Crawfurd became a regular writer on ethnology (...) and Asian affairs for the Examiner newspaper and in the 1860s he was President of the Ethnological Society of London. Accounts of nineteenth-century anthropology in Britain characterise debate around race as falling into two camps: advocates of monogenesis and advocates of polygenesis. In the United States of America, advocates of polygenesis were often associated with advocates of slavery and racial inequality. Recent research has demonstrated that Charles Darwin’s hatred of slavery drove him to write Origin of the Species to demonstrate the unity of the human species and reject the polygenesis position. This paper explores Crawfurd’s ideas and demonstrates that a belief in polygenesis in the nineteenth century did not necessarily equate with a belief in racial inequality. (shrink)

We consider the question of when an expansion of a first-order topological structure has the property that every open set definable in the expansion is definable in the original structure. This question has been investigated by Dolich, Miller and Steinhorn in the setting of ordered structures as part of their work on the property of having o-minimal open core. We answer the question in a fairly general setting and provide conditions which in practice are often easy to check. We give (...) a further characterisation in the special case of an expansion by a generic predicate. (shrink)

Computational simulations have provided evidence that the use of linguistic cues as group markers plays an important role in the development of linguistic diversity shortcite. Other simulations, however, have contradicted these findings. Similar disagreements exist in sociolinguistics. This paper describes an experimental study in which participants played an anonymous economic game using an instant-messenger-style program and an artificial ‘alien language’. The competitiveness of the game and the frequency with which players interacted were manipulated. Given frequent enough interaction with team-mates, players (...) were able to use linguistic cues to identify themselves. In the most competitive condition, this led to divergence in the language, which did not occur in other conditions. This suggests that both frequency of interaction and a pressure to use language to mark identity play a significant role in encouraging linguistic divergence over short periods, but that neither is suffi cient on its own. (shrink)

Computational simulations have provided evidence that the use of linguistic cues as group markers plays an important role in the development of linguistic diversity shortcite. Other simulations, however, have contradicted these findings. Similar disagreements exist in sociolinguistics. This paper describes an experimental study in which participants played an anonymous economic game using an instant-messenger-style program and an artificial ‘alien language’. The competitiveness of the game and the frequency with which players interacted were manipulated. Given frequent enough interaction with team-mates, players (...) were able to use linguistic cues to identify themselves. In the most competitive condition, this led to divergence in the language, which did not occur in other conditions. This suggests that both frequency of interaction and a pressure to use language to mark identity play a significant role in encouraging linguistic divergence over short periods, but that neither is suffi cient on its own. (shrink)