This chapter contains sections titled: Sartre's Life Early Phenomenological Works Phenomenological Ontology: Being and Nothingness Phenomenological Marxism Conclusion.

Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Camus’s Meursault and Sartrian IrresponsibilityDavid ShermanIn the wake of poststructuralism, with its glorification of the libidinal play of unaccountable, fragmented subjectivities, the concept of personal responsibility has been rehabilitated. From the French fascination with various forms of neo-Kantianism to the American interest in homey (albeit demagogic) books on the virtues, personal responsibility is regaining currency. But what, exactly, does it mean to be personally responsible? When Albert Camus suggested (...) in “Neither Victims Nor Executioners” that non-violence was the “responsible” position for intellectuals to take on the Algerian crisis, he was reproached for legalistically evading responsibility by his erstwhile friend Jean-Paul Sartre. Sartre, who offered up the concept of “absolute responsibility,” and viewed any attempt to obscure the nature of this ontological burden for oneself as “bad faith,” regarded Camus’s position as just such an attempt: “If you’re not victims when the government which you voted for, when the army in which your younger brothers are serving... have undertaken race murder, you are, without a shadow of a doubt, executioners.” 1 For Sartre, who tentatively advocated revolutionary violence, taking responsibility meant acknowledging that “bloodying one’s hands” is unavoidable.The concept of personal responsibility is well considered within the context of French existentialism, which made it one of its hallmarks. In this essay, however, I shall approach personal responsibility from the vantage point of its opposite, personal irresponsibility. Towards this end, I shall consider Meursault, the protagonist in Camus’s The Stranger, whom I take to be one of the most irresponsible characters in literature. The depths of Meursault’s irresponsibility can best be appreciated, fittingly enough, within Sartre’s psychoanalytic framework. [End Page 60]IIn Being and Nothingness, Sartre offers up the ontologically rooted phenomenon of bad faith, which, for present purposes, can be explicated as follows: consciousness, which is intentional (nothing more than that which it is conscious of), reflectively reconstitutes the Self, which does not exist in consciousness but as an object in the external world. There is no intrinsic Self, and the Self that does exist is perpetually being transcended. Despite this state of unremitting transcendence, however, at any point in time there are the undeniable facts of our particular existences, which (however we choose to interpret them) define the range of our possible projects. These brute facts, which are inexorable, constitute our facticity. Thus, Sartre tells us, there is a “double property of the human being, who is at once a facticity and a transcendence” (B&N, p. 98). 2 It is in a person’s approach to the relationship between these two properties, which is marked by an irresolvable tension, that bad faith arises: “Bad faith does not wish either to coordinate them or to surmount them in a synthesis. Bad faith seeks to affirm their identity while preserving their differences. It must affirm facticity as being transcendence and transcendence as being facticity, in such a way that at the instant when a person apprehends the one, he can find himself abruptly faced with the other” (B&N, p. 98).Sartre provides numerous illustrations of individuals who flee from either their facticity or transcendence. For example, there is the homosexual and his interlocutor, the “champion of sincerity.” The former, despite repeated homosexual encounters, refuses to draw the conclusion that he is a homosexual; instead, he sees both his past behavior and his present inclinations as part of a “restless search.” Conversely, the latter demands that the homosexual sincerely avow what he is, “a homosexual.” Both are in bad faith. The homosexual denies responsibility for all that he has done by perpetually pushing his conception of Self into the future, and thus perpetually beyond the reach of his ability to make judgments about himself—he makes a mockery of his past and present choices. The champion of sincerity, on the other hand, pushes the homosexual’s conception of Self into the past in order to make it a thing—he denies the homosexual’s (and perhaps his own) freedom to make future choices, which is what enables us to transcend what we presently are. The former flees facticity; the latter, transcendence.All persons in bad faith fall... (shrink)

Paul Weiss continues the brilliant analysis of art he began in _The World of Art _and _Nine Basic Arts_—here_ _in the medium of film, at which he takes a close and inde­pendent look. Writing in a vigorous, jargon-free style, and covering all aspects of films and film making, Mr. Weiss presents a fresh, new approach to the study of our newest art. During the course of writing _Cinematics_,_ _Mr. Weiss asked various writers, critics, scholars, and producers long involved with (...) film to read and remark on what he had written. Five of them—Eric Sherman, Joseph Williman, Arthur Knight, David Slavitt, and Robert Thom—provided comments which are incorporated in the text. Their remarks are often trenchant, and perceptively provocative. These men frequently comment on lines of inquiry suggested in the book and often take issue with what has been said. The result is a kind of dialogue crisscrossed with stimu­lating insights. While this book is aimed at the general reader, Mr. Weiss hopes that experts and practitioners of film making will benefit from this fresh, independent, and philo­sophically based inquiry. Readers already familiar with Mr. Weiss’s writings will delight in this distillation of his thought on an art so intimately a part of our cul­ture. (shrink)

This useful, introductory guide to Continental philosophy is another fine volume within the Blackwell Philosophy Guides series, whose editor is Steven M. Cahn. Robert Solomon teaches business and philosophy at the University of Texas at Austin, and David Sherman teaches philosophy at the University of Montana–Missoula.

erkennung der Postmodernität: Hilfen für Historiker – und Historiker der Wissenschaften im Besonderen. Ausgehend von einer Unterscheidung zwischen der Postmodernit?t als einer von der Modernit?t durch eine breite Umkehr ihrer kulturellen Grundannahmen abgegrenzten historischen Ära und dem Postmodernismus – einer von den selbsternannten Postmodernisten in der frühen Postmodernität angenommenen intellektuellen Attitüde – thematisiert der Aufsatz zwei grundsätzliche Charakteristika der Postmodernität: Erstens die Umkehrung der kulturellen Rangfolge von Wissenschaft und Technik, worin Postmodernität und Postmodernismus übereinstimmen. Zweitens die Ablösung des Ideals eines (...) methodisch vorgehenden, uneigennützigen Wissenschaftlers, nicht durch ein fragmentiertes Subjekt, wie der Postmodernismus behauptet, sondern durch den einseitig interessierten Unternehmer, welcher unter Missachtung aller Regeln hartnäckig seine Eigeninteressen verfolgt. Diese Umkehr in Bedeutung und Rolle von Wissenschaft und Technologie, die um 1980 begann, ist ein Kennzeichen des Übergangs von der Modernit?t zur Postmodernität. Diese Umkehr ist primär zu erkennen als eine Ablehnung des Regelhaften, des methodischen Vorgehens – mit dem “Methodismus” als einer die Modernität auszeichnenden kulturellen Perspektive – aber auch als eine Ablehnung der Uneigennützigkeit, einer in der Modernität besonders wert geschätzten Geisteshaltung. Postmodernität konstituiert sich somit als diese Umwertung der Werte, die ihre Quelle im ich-fixierten, transgressiven und “risiko”-freudigen postmodernen Individuum und seinen anti-sozialen Annahmen in Bezug auf Persönlichkeit hat. In der Wissenschaftsgeschichte selbst findet sich daher seit circa 1980 ein entsprechender Wandel der wissenschaftlichen Aufmerksamkeit weg von der Wissenschaft und hin zur Technologie. Damit einhergeht eine erstaunliche Vermeidung sozialhistorischer Perspektivierung, wie sie sich nicht zuletzt in der Abkehr von kausalistischen “Einfluss”-Erklärungen zugunsten voluntaristischer “Ressourcen”-Erklärungen spiegelt.cognizing Postmodernity: Helps for Historians – of Science Especially. stmodernity, a historical era demarcated from modernity by a broad reversal in cultural presuppositions, is distinguished from postmodernism, an intellectual posture adopted by self-identified postmodernists early in postmodernity. Two principal features of postmodernity are addressed: first, the downgrading of science and the upgrading of technology in cultural rank – on which postmodernity and postmodernism are in accord; second, the displacement of the methodical, disinterested scientist, modernity's beau ideal, not by a fragmented subject as postmodernism claims, but by the single-minded entrepreneur, resourcefully pursuing his self-interest in disregard of all rules. The reversal in rank and role as between science and technology, setting in circa 1980, is a marker of the transition from modernity to postmodernity. That reversal is to be cognized primarily as rejection of rule-following, of proceeding methodically – ‘methodism’ being the cultural perspective that uniquely distinguished modernity – but also as rejection of disinterestedness, the quality of mind especially highly esteemed in modernity. Postmodernity is constituted by this transvaluation of values, whose well-spring is the egocentric, transgressive , postmodern personality and its anti-social presumptions regarding personhood. Within the history of science itself there has been since circa 1980 a corresponding turn of scholarly attention away from science to technology, and a growing distaste for social perspectives, reflected, i. a., in the rejection of causalist ‘influence’ explanations in favor of voluntarist ‘resource’ explanations. (shrink)

The philosophy of Samuel Clarke is of central importance for an adequate understanding of Hume’s Treatise.2 Despite this, most Hume scholars have either entirely overlooked Clarke’s work, or referred to it in a casual manner that fails to do justice to the significance of the Clarke-Hume relationship. This tendency is particularly apparent in accounts of Hume’s views on space in Treatise I.ii. In this paper, I argue that one of Hume’s principal objectives in his discussion of space is to discredit (...) Clarke’s Newtonian doctrine of absolute space and, more deeply, the ‘argument a priori’ that Clarke constructs around it. On the basis of this interpretation, I argue that Hume’s ‘system’ of space constitutes an important part of his more fundamental ‘atheistic’ or anti- Christian objectives in the Treatise.3. (shrink)

Science and the History of the Sciences. Conceptual Innovations Through Historicizing Science in the Eighteenth Century. The historical reconstruction of science is linked to philosophical discussions of the eighteenth century in many ways. The historiography of philosophy and the historiography of science share the conceptual problem to assemble the multitude of scientific and philosophical practices under general concepts. The historical analysis of scientific progress offers a clue by problematizing definitions of “science” and “sciences” as well as the system of sciences (...) as a whole. By analyzing these conceptual problems and the typology of historical enterprises of the eighteenth century, this paper will discuss the close interrelations which existed between philosophical and historical discourses of eighteenth‐century reflection on science. (shrink)

If there is to be any progress in the debate about what sort of positive moral status Kant can give the emotions, we need a taxonomy of the terms Kant uses for these concepts. It used to be thought that Kant had little room for emotions in his ethics. In the past three decades, Marcia Baron, Paul Guyer, Barbara Herman, Nancy Sherman, Allen Wood and others have argued otherwise. Contrary to what a cursory reading of the Groundwork may (...) indicate, Kant thinks the emotions play an important role in the moral life. I want to extend the work of Baron, Guyer, Herman, Sherman and Wood in three ways. First, I will set out in a diagram Kant's taxonomy of feelings and emotions. Agreement on such a taxonomy should make it easier to evaluate debates about Kant and the emotions. Second, I will focus on a certain subclass of emotions – reason-caused affects – that have previously received little attention, even from these Kant scholars. Third, these scholars base much of their defence of Kant on his later works – especially the Metaphysics of Morals and the Anthropology – but Kant's fairly rich taxonomy of the emotions, including reason-caused affects, is clearly in place at least as early as the Critique of Judgment . I believe that the Critique of Judgment is an importantly ignored resource for understanding the moral role of the emotions for Kant. The third Critique makes positive, philosophically interesting claims about the emotions and morality. Kant emphasizes certain roles for emotions in this work that he develops to the same extent nowhere else. Nevertheless, the Critique of Judgment goes all but unmentioned by many who write on these issues. In what follows, I will defend as many of my claims as possible using the third Critique. (shrink)

Compatibilism combines an externalist view of mental content with a doctrine of privileged self‐knowledge. The essay presents a reductio of compatibilism by arguing that if compatibilism were true, we would be in a position to know certain facts about the world a priori, facts that no one can reasonably believe are knowable a priori. Whether this should be taken to cast doubt on externalism or privileged self‐knowledge is not discussed. Consideration is given to the ’empty case’—the case in which a (...) thinker expresses what he takes to be a genuine thought concerning a natural kind but where there is in fact no relevant natural kind, so that the putative natural kind term fails to refer. It is argued that, in such a case, on an externalist conception of natural kind terms, the thinker is deluded in taking himself to be expressing a complete thought, and that such delusions are not compatible with privileged self‐knowledge. (shrink)

According to Aristotle, there are three qualitatively different forms of rule: royal, political, and despotic. Royal and political rule are free, while despotic rule is unfree. In unfree rule the ruler rules in his own interest. But free men deserve to be ruled in their own interests, which occurs in royal and political rule. In political rule some of the ruled have a right to participate in public life. Being a citizen does not necessarily mean, however, having the right to (...) higher office. In actual constitutions, the distribution of political power beyond that accompanying mere citizenship usually depends on an additional criterion. Political virtue is the best criterion because officials possessing it are most likely to produce a happy citizenry. If a political community has a man with political virtue that outweighs that of all others combined, no other man is qualified to participate in public deliberation and judgment, to be a citizen. Under this royal rule, there is neither shared rule nor rule of law. Despite this Aristotle says that royal rule is better than political rule. A king is more effectively able to produce a happy population than would any multitude of citizens ruling jointly. This means that one need not be a citizen, let alone hold high office, to be happy. In fact happiness primarily consists in philosophical contemplation, for which there is more time in a monarchy. Corresponding to the three kinds of rule there were three dimensions to Aristotle's practical policies. (shrink)

This work reconstructs the original theory of natural law as developed by the early Stoic scholarchs, explains its fundamental differences from our traditional conception of natural law, and considers the philosophical motivation for this transformation of the original theory. For the nearly Stoics, natural law corresponds not to a determinate code of laws or precepts, as in Aquinas, but to a certain mental disposition, namely the perfectly rational and consistent conduct of the wise man. The content of the moral conduct (...) enjoined by natural law is specified by "virtuous actions" rather than "appropriate actions" . ;In the Introduction I discuss the central differences between ancient and modern theories of natural law, outline the plan of my project, and explain how the early Stoic theory of natural law differs quite radically from the Thomistic conception of the subject. Next I reconstruct the original form and motivation of the theory from the fragments of the early Stoic scholarchs, explain its relation to their ethics and political philosophy, and show that its original motivation was to offer a better answer than Plato had succeeded in giving to the problems he raised in the Republic. In the third chapter I reconstruct and examine critically Carneades' attack on the Stoic theory. Finally, I argue that Antiochus of Ascalon introduced a simple but fundamental modification of the early Stoic theory, which radically changed its orientation and laid the basis for the Thomistic theory. To support his view about the unity of doctrine of the "ancients", Antiochus revised natural law so as to enjoin kathekonta rather than katorthomata, thus making the content of natural law correspond to a determinate class of precepts. I conclude with some general remarks on why Cicero chose Antiochus' version of natural law as the basis for his De Legibus. In an Appendix I argue that the Stoics' theory had little if any substantive influence on Roman Jurisprudence. (shrink)

Collective rationality in its ordinary sense is rationality’s extension to groups. It does not entail efficiency by definition. Showing that it entails efficiency requires a normative argument. Game theorists treating cooperative games generally assume that collective rationality entails efficiency, but formulating the reasoning that leads individuals to efficiency, and verifying the rationality of its steps, presents challenging philosophical issues. This paper constructs a framework for addressing those issues and reaches some preliminary results about the prospects of rational agents achieving efficiency (...) in coalitional games. It concludes that only under strong idealizations does collective rationality entail efficiency. (shrink)

The ‚Naturforschende Gesellschaft’︁, founded in 1793, proved instrumental for the development of science at the University of Jena around 1800. Its library can be considered as one of its most important facilities provided for research and for the education of students. Since this library has been preserved almost without losses, we can ask whether this library served the purpose of a research library in the newly established field of ‚science’︁. In consequence, the role of scientific societies and the genesis of (...) specialised libraries in the area of science can be investigated in an exemplary case, with implications for the concept of scientific research around 1800. (shrink)

Paul Snowdon; XI*—Perception, Vision and Causation, Proceedings of the Aristotelian Society, Volume 81, Issue 1, 1 June 1981, Pages 175–192, https://doi.org/10.

This edited collection sets forth a new understanding of aesthetic-moral judgment organised around three key concepts: pleasure, reflection, and accountability. The overarching theme is that art is not merely a representation or expression like any other, but that it promotes shared moral understanding and helps us engage in meaning-making. This volume offers an alternative to brain-centric and realist approaches to aesthetics. It features original essays from a number of leading philosophers of art, aesthetics, ethics, and perception, including Elizabeth Burns Coleman, (...) Garrett Cullity, Cynthia A. Freeland, Ivan Gaskell, Paul Guyer, Jane Kneller, Keith Lehrer, Mohan Matthen, Jennifer A. McMahon, Bence Nanay, Nancy Sherman, and Robert Sinnerbrink. Part I of the book analyses the elements of aesthetic experience— pleasure, preference, and imagination—with the individual conceived as part of a particular cultural context and network of other minds. The chapters in Part II explain how it is possible for cultural learning to impact these elements through consensus building, an impulse to objectivity, emotional expression, and reflection. Finally, the chapters in Part III converge on the role of dissonance, difference, and diversity in promoting cultural understanding and advancement. Social Aesthetics and Moral Judgment will appeal to philosophers of art and aesthetics, as well as to scholars in other disciplines interested in issues related to art and cultural exchange. (shrink)

The volume brings together ancient-philosophy specialists and Kant scholars to advance our understanding of the significance of Stoicism for Immanuel Kant's ethical thought. Kant and Stoic Ethics -/- Contents: -/- Introduction -/- 1 Ethical Formulae in Ancient Stoicism — Brad Inwood -/- 2 Duties and Permissible Actions in the Early Stoics and Kant — Iakovos Vasiliou -/- 3 The Stoics and Kant on the Motive of Duty — Jacob Klein -/- 4 Kant on the Unity and Plurality of the Virtues (...) — Katja Maria Vogt -/- 5 Perfection and Morality — Stephen Engstrom -/- 6 The Stoical Sublime — I.S. Blecher 7 Kant’s Rejection of Stoic Eudaimonism — Michael Vazquez -/- 8 Life as a Game of Skill? Kant and the Stoics about the Results of Human Agency — Jens Timmermann -/- 9 Living in accordance with Nature: Kant and Stoicism — Paul Guyer -/- 10 On the Relationship between Orientation and Agency: From the Stoics’ Oikeiōsis to Kant’s Orientierung — Alix Cohen -/- 11 “Everyone has a price at which he sells himself”: Epictetus and Kant on Self-respect — Melissa Merritt -/- 12 Anger Reinstated: Stoics and Kant on Anger — Nancy Sherman 13 Kant’s Philosophy of History as Stoic Consolation — Rachel Zuckert -/- Bibliography Index . (shrink)

This study examines how hunger narratives and performances contribute to a reconsideration of neglected or prohibited domains of thinking which only a full confrontation with the body's heterogeneity and plasticity can reveal. From literary motif or psychosomatic symptom to revolutionary gesture or existential malady, the double crux of hunger and disgust is a powerful force which can define the experience of embodiment. Kafka's fable of the "Hunger Artist" offers a matrix for the fast, while its surprising last-page revelation introduces disgust (...) as a correlative of abstinence, conscious or otherwise. Grounded in Kristeva's theory of abjection, the figure of the fraught body lurking at the heart of the negative grotesque gathers precision throughout this study, where it is employed in a widening series of contexts: suicide through overeating, starvation as self-performance or political resistance, the teratological versus the totalitarian, the anorexic harboring of death. In the process, writers and artists as diverse as Herman Melville, Percy Bysshe Shelley, Christina Rossetti, George Orwell, Knut Hamsun, J.M. Coetzee, Cindy Sherman, Pieter Breughel, Marina Abramovic, David Nebreda, Paul McCarthy, and others are brought into the discussion. By looking at the different acts of visceral, affective, and ideological resistance performed by the starving body, this book intensifies the relationship between hunger and disgust studies while offering insight into the modalities of the "dark grotesque" which inform the aesthetics and politics of hunger. It will be of value to anyone interested in the culture, politics, and subjectivity of embodiment, and scholars working within the fields of disgust studies, food studies, literary studies, cultural theory, and media studies. (shrink)

Paul Abela presents a powerful, experience-sensitive form of realism about the relation between mind and world, based on an innovative interpretation of Kant. Abela breaks with tradition in taking seriously Kant's claim that his Transcendental Idealism yields a form of empirical realism, and giving a realist analysis of major themes of the Critique of Pure Reason. Abela's blending of Kantian scholarship with contemporary epistemology offers a new way of resolving philosophical debates about realism.

The Theaetetus is one of the most widely studied of any of the Platonic dialogues because its dominant theme concerns the significant philosophical question, what is knowledge? In this book Paul Stern provides a full-length treatment of its political character in relationship to this dominant theme. He argues that this approach sheds significant light on the distinctiveness of the Socratic way of life, with respect to both its initial justification and its ultimate character. More specifically, he argues that Socrates' (...) revolutionary decision to subject political life to philosophic reflection, the decision that leads directly to his trial and execution, is based on his awareness of the elusiveness of comprehensive knowledge and the implications of that elusiveness for the validity of philosophic inquiry. This view of Socrates' rationale has important consequences for our understanding of political philosophy and of the validity of the life of reason itself. (shrink)

In ‘Levinas: Ethics or Mystification?’ (Miller, 2017), Alistair Miller presents a searing indictment of the philosophy of Emmanuel Levinas and a dismissal of claims for its importance for education. He provides a summary account of Levinas's philosophy and, in relation to this, refers briefly to a number of authors who have related Levinas's work to education. This account is at fault, however, in fundamental ways, and this leads to errors in the conclusions that he draws. The present short paper does (...) not attempt to address these problems in the round but rather focuses on a particular aspect of his phrasing in constructing the account, taking this as a significant pointer to the nature of the misinterpretation as a whole. (shrink)