The American Journal of Bioethics, Volume 12, Issue 8, Page 19-20, August 2012.

Determinations of the ethical acceptability of genetic therapy have relied on several distinctions in attempts to separate ethically acceptable genetic therapy from those possible therapies that could lead to genetic modifications of future human beings. One distinction that has been proposed is that genetic modifications of human somatic cells is ethically acceptable but that Germ-Line genetics modifications would be ethically objectionable. This paper examines several serious difficulties which call into question the ethical relevance of a somatic/Germ-Line distinction. Keywords: double effect, (...) future generations, Germ-Line modification CiteULike Connotea Del.icio.us What's this? (shrink)

(2001). Family Physicians and the Family Covenant Model's Usefulness in Solving Genetic Testing Conflicts. The American Journal of Bioethics: Vol. 1, No. 3, pp. 28-29.

Modern medicine has put a new twist on one of our most fundamental values: self-determination. Although advance directives may be used to request treatment, this volume limits its focus to their more common function--the refusal of treatment. Timely and comprehensive, it provides a stimulating overview of this relevant topic, addressing such questions as: What are the individual and societal benefits of advance directives? Does an advance directive tamper with the sanctity of life? Will normalizing directives have an adverse effect on (...) the practice of medicine? Should a patient specify treatments to be withheld within a directive? What legal sanctions should apply against those who ignore directives? and What is a physician's role in helping his patient formulate an appropriate directive? (shrink)

In lieu of an abstract, here is a brief excerpt of the content:178 Reviews c:\users\kenneth\documents\type3302\rj 33,2 113 red.docx 2014-01-15 10:04 THE EARLY MOORE AND RUSSELL Ray Perkins, Jr. Philosophy / Plymouth State U. Plymouth, nh 03264 1600, usa [email protected] G. E. Moore. Early Philosophical Writings. Edited and with an Introduction by Thomas Baldwin and Consuelo Preti. Cambridge and New York: Cambridge U. P., 2011. Pp. lxxxv, 251. isbn: 978-0521190145. £68.00; us$114.00. aldwin and Preti have put together a very nice book (...) which gives us G. E. Moore’s 1897 and 1898 Trinity College dissertations and an informative look at the historical context in which they were written. This story—including information about Moore’s early life, the philosophical influences at Cambridge and a critical commentary on his dissertations and readers’ reports— is clearly and carefully presented in their 78-page introduction.1 The book is a valuable addition to the history of analytic philosophy and will be of special interest to Moore (and Russell) scholars and to historians generally who wish to know more about the genesis of the ideas shaping the new analytic philosophy at the end of the century. Moore entered Trinity in 1892 to study classics. There he met Russell (who was in his third year) and took his advice to study philosophy in his last two years and take his final exams (Tripos, Part ii) in both disciplines, which he did successfully in 1896. And like Russell—who had won a Trinity prize fellowship in 1895 (with a dissertation on the foundations of geometry2 ) only one year after his graduation—he submitted a dissertation (1897) in hopes of winning a prize fellowship. Moore’s first attempt failed, but his 1898 version was successful. And not only did the success of the 1898 dissertation launch Moore’s career as a professional philosopher, it also paved the way for the new analytic philosophy of the next century. Moore’s dissertations and his Trinity examiners’ reports (by Caird, Sidgwick, Ward and Bosanquet3 ) are fascinating reading, and it’s a great convenience to have them handy in a single volume. But the editors deserve special 1 Hereafter I shall use the editors’ convention of referring to the pagination of their introduction with roman numerals and to Moore’s dissertations (plus examiners’ reports) with arabic numerals. 2 Russell’s dissertation was published in 1897 as An Essay on the Foundations of Geometry. 3 Edward Caird was an idealist and highly respected Kant scholar at Oxford. Henry Sidgwick was one of Moore’s teachers at Cambridge and author of the influential _= Reviews 179 c:\users\kenneth\documents\type3302\rj 33,2 113 red.docx 2014-01-15 10:04 praise for not only giving the reader an astute critical summary of the dissertations, but also for their skillful reconstruction of Moore’s surviving, but incomplete, 1898 manuscript from which parts of the early chapters had been removed. The editors make a good case (pp. lxxv–lxxix) that those pages became the basis of Moore’s 1899 Mind article, “The Nature of Judgment”. (Those familiar with Russell’s early work may recall it as an article that Russell claimed as of paramount importance for his own early work.4 I’ll return to the question of Russell and Moore and this article’s significance.) the dissertations, 1897 and 1898 Moore’s dissertations reveal a young Moore with remarkable powers of analysis and more than a hint of the careful, courageous scepticism and intellectual honesty for which he later became known. But as the editors make clear, their main importance is the record they reveal of the transition away from Kant and Hegel to the new philosophy, which put a premium on conceptual analysis and metaphysics without Kantian or neo-Hegelian idealism. The 1897 dissertation (“The Metaphysical Basis of Ethics”) is an analysis of the basic concepts of ethics with considerable critical discussion of Kant, especially concerning freedom and reason, and Moore’s attempt to fashion his own good-based ethics utilizing a little from Kant and much from Bradley (p. l). At this time both Moore and Russell were still under the influence of Kant... (shrink)

“Marlowe wrote Edward The Second in 1590. He found a suitable tragic theme in the Holinshed’s account of Edward II’s reign though it was not a promising dramatic material from the chronological point of view as the events were disjointed and uninspiring disastrous. Improper coordinates of the sources has left its mark on Marlowe’s play, nevertheless, this is his most finished and satisfactory of plays…Edward The Second can surely be regarded as Marlowe’s finest technical achievement.” (Edited, Dr. (...) S. Sen…). (shrink)

"ON DEMAND OF A PUBLISHING HOUSE IN GERMANY, I WAS ASKED TO WRITE ON SCIENTIFIC METHODS THAT I HAD imbibed ON WRITING THE DOCUMENT" [Thanks to accept my work Christopher Marlowe's Edward The Second from Presidency College,Kolkata of interest to international audience] .

A theoretical device, which incorporates the functions of clock, rod, nonrotating platform, and accelerometer, and whose operation depends on the properties of light rays and free particles, is defined. The device, which we call a metrosphere, is simple enough that it can be introduced at the starting point of relativity theory and versatile enough that it can serve as an aid in the development and conceptualization of the theory. Relative to an inertial frame, a moving metrosphere undergoes a Lorentz-Fitzgerald contraction (...) and the associated clock exhibits a Lorentz-Larmor rate retardation. From this fact and the assumption that there exists one inertial frame, it is possible to generate the kinematical results of special relativity. A metrosphere provides an observer with a local frame of reference, hence it is well adapted to the needs of general relativity, allows the equivalence principle to be introduced in a straightforward manner, and permits a smooth transition from special relativity to general relativity. (shrink)

This paper assesses possible reasons why Hermann J. Muller avoided peer-review of data that became the basis of his Nobel Prize award for producing gene mutations in male Drosophila by X-rays. Extensive correspondence between Muller and close associates and other materials were obtained from preserved papers to compliment extensive publications by and about Muller in the open literature. These were evaluated for potential historical insights that clarify why he avoided peer-review of his Nobel Prize findings. This paper clarifies the basis (...) of Muller’s (Muller HJ, Sci 66 84-87, 1927c) belief that he produced X-ray induced “gene” mutations in Drosophila. It then shows his belief was contemporaneously challenged by his longtime friend/confidant and Drosophila geneticist, Edgar Altenburg. Altenburg insisted that Muller may have simply poked large holes in chromosomes with massive doses of X-rays, and needed to provide proof of gene “point” mutations. Given the daunting and uncertain task to experimentally address this criticism, especially within the context of trying to become first to produce gene mutations, it is proposed that Muller purposely avoided peer-review while rushing to publish his paper in Science to claim discovery primacy without showing any data. The present paper also explores ethical issues surrounding these actions, including those of the editor of Science, James McKeen Catell and Altenburg, and their subsequent impact on the scientific and regulatory communities. This historical analysis suggests that Muller deliberately avoided peer-review on his most significant findings because he was extremely troubled by the insightful and serious criticism of Altenburg, which suggested he had not produced gene mutations as he claimed. Nonetheless, Muller manipulated this situation (i.e., publishing a discussion within Science with no data, publishing a poorly written non-peer reviewed conference proceedings with no methods and materials, and no references) due to both the widespread euphoria over his claim of gene mutation and confidence that Altenburg would not publically challenge him. This situation permitted Muller to achieve his goal to be the first to produce gene mutations while buying him time to later try to experimentally address Altenburg’s criticisms, and a possible way to avoid discovery of his questionable actions. (shrink)

This article examines the process theodicies of David Ray Griffin and Philip Clayton. It explains their differences on such issues as God’s primordial power and voluntary self-limitation, creativity as an independent metaphysical principle that limits God, creation out of nothing or out of chaos, and God’s voluntary causal naturalism. Difficulties with their positions are discussed. The Clayton-Knapp “no-not-once” principle is explained, and a more comprehensive process theodicy is outlined.

We describe our explicit Lorentz-invariant solution of the Einstein and null geodesic equations for the deflection experiment of 2002 September 8 when a massive moving body, Jupiter, passed within 3.7’ of a line-of-sight to a distant quasar. We develop a general relativistic framework which shows that our measurement of the retarded position of a moving light-ray deflecting body (Jupiter) by making use of the gravitational time delay of quasar’s radio wave is equivalent to comparison of the relativistic laws of the (...) Lorentz transformation for gravity and light. Because, according to Einstein, the Lorentz transformation of gravity field variables must depend on a fundamental speed c, its measurement through the retarded position of Jupiter in the gravitational time delay allows us to study the causal nature of gravity and to set an upper limit on the speed of propagation of gravity in the near zone of the solar system as contrasted to the speed of the radio waves. In particular, the v/c term beyond of the standard Einstein’s deflection, which we measured to 20% accuracy, is associated with the aberration of the null direction of the gravity force (“aberration of gravity”) caused by the Lorentz transformation of the Christoffel symbols from the static frame of Jupiter to the moving frame of observer. General relativistic formulation of the experiment identifies the aberration of gravity with the retardation of gravity because the speed of gravitational waves in Einstein’s theory is equal to the speed of propagation of the gravity force. We discuss the misconceptions which have inhibited the acceptance of this interpretation of the experiment. We also comment on other interpretations of this experiment by Asada, Will, Samuel, Pascual–Sánchez, and Carlip and show that their “speed of light” interpretations confuse the Lorentz transformation for gravity with that for light, and the fundamental speed of gravity with the physical speed of light from the quasar. For this reason, the “speed of light” interpretations are not entirely consistent with a retarded Liénard–Wiechert solution of the Einstein equations, and do not properly incorporate how the phase of the radio waves from the quasar is perturbed by the retarded gravitational field of Jupiter. Although all of the formulations predict the same deflection to the order of v/c, our formulation shows that the underlying cause of this deflection term is associated with the aberration of gravity and not of light, and that the interpretations predict different deflections at higher orders of v/c beyond the Shapiro delay, thus, making their measurement highly desirable for deeper testing of general relativity in future astrometric experiments like Gaia, SIM, and SKA. (shrink)

This article attempts to present an X-ray of reactionary populism in power by describing how several ideological elements of Brazilian and international political culture that have gathered by the far rightwing movement led by Jair Bolsonaro. The authors hark back to the politological debate on right-wing populism and conclude with an analysis of bolsonarismo as “lulismo in reverse” [às avessas].

Can we learn without consciousness? When the eminent neuropsychologist, Lawrence Weiskrantz first coined the term 'blindsight' to describe a condition whereby a patient could demonstrate that they were aware of some object, yet insist that they were completely unaware of its existence, the response from some in the scientific community was one of extreme skepticism. Even now, there are those who question the existence of unconscious learning, and the topic remains one of the most actively researched and debated in psychology. (...) In recent years evidence for unconscious processing across a range of sensory modalities have come from studies of vision, audition, memory, emotion, and action. Never before have these studies of unconscious processing in the different senses been brought together into a single volume. In a book dedicated to Lawrence Weiskrantz, some of the leading psychologists and cognitive neuroscientists of the day explain what we know about unconscious processing in the different senses. Including contributions from, amongst others, David Milner, Jon Driver, Alan Cowey, and Ray Dolan, the book presents a state of the art account of what we now know about 'the unconscious'. The book will provide a fascinating account for students and researchers in psychology, cognitive neuroscience, and philosophy. (shrink)

The Stanford Encyclopedia of Philosophy is an open access, dynamic reference work designed to organize professional philosophers so that they can write, edit, and maintain a reference work in philosophy that is responsive to new research. From its inception, the SEP was designed so that each entry is maintained and kept up to date by an expert or group of experts in the field. All entries and substantive updates are refereed by the members of a distinguished Editorial Board before they (...) are made public. (shrink)

This volume contains two major manuscript notebooks of Jonathan Edwards—"Natural Philosophy" and "The Mind"—as well as a number of shorter manuscript writings connected with his scientific interests and philosophical development. Several of the shorter papers have not previously been published, notably Edwards’ letter on the "flying" spider, an essay on light rays, and a brief but important set of philosophical notes written near the end of his life. Wherever possible the works have been newly transcribed from manuscript originals. Wallace Anderson (...) has collected, edited, and presented them here in a thoroughly authentic and readable text. Each of the major works in this volume and each group of related writings are preceded by detailed discussion of manuscript sources and dates. In his introduction Anderson makes these the basis for a revised account of the chronology of Edwards’ early writings and a deeper investigation of their biographical and historical context. Also included in the introduction are a new appraisal of Edwards’ efforts and achievements in science and an analysis of the developmental of his philosophical views. Anderson concludes from his research that Edwards was an enthusiastic, though untrained, investigator in the Newtonian tradition and that he grappled with the major metaphysical problems raised by this tradition. The papers reveal with special clarity the fertile and inquiring mind of our leading eighteenth-century philosopher-theologian. _Wallace E. Anderson_ is associate professor of philosophy at Ohio State University. (shrink)

In 2014, Ray Yeo published a modified account of the Spirit’s indwelling in “Towards a Model of the Indwelling: A Conversation with Jonathan Edwards and William Alston.” Yeo utilizes a conglomerate of Two-Minds Christology and Spirit Christology to provide a metaphysical framework for his model which he believes offers a viable alternative to more traditional merger accounts like those of Edwards and Alston. After providing an overview of Yeo’s objections to the merger accounts of Alston and Edwards, I will summarize (...) Yeo’s modified model. I will argue Yeo’s emphasis on the humanity of Christ in lieu of a literal, internal, and direct union of the Holy Spirit and the human person cannot alleviate the core metaphysical concerns which surface in all accounts of union between the divine and human. Yeo’s misunderstanding of Two-Minds Christology leads him to deny the full humanity of Christ; a humanity upon which his entire account of the indwelling relies. Yeo’s modified model will be shown unsuccessful as an account of the indwelling of the Holy Spirit even if one accepts both his conception of Two-Minds Christology and his conditions for indwelling. (shrink)

Since the practice turn, the role technologies play in the production of scientific knowledge has become a prominent topic in science studies. Much existing scholarship, however, either limits technology to merely mechanical instrumentation or uses the term for a wide variety of items. This article argues that technologies in scientific practice can be understood as a result of past scientific knowledge becoming sedimented in materials, like model organisms, synthetic reagents or mechanical instruments, through the routine use of these materials in (...) subsequent research practice. The proposed theoretical interpretation of technology is examined through a case where a model organism—Drosophila melanogaster—acted as a technology for investigating a contested biological effect of a mechanical instrument: Hermann J. Muller’s experiments on X-ray mutagenicity in the 1920s. The article reconstructs how Muller employed two synthetic Drosophila stocks as tests for measuring X-rays’ capacity to cause genetic aberration. It argues that past scientific knowledge sedimented in the Drosophila stocks influenced Muller’s perception of X-ray-induced mutation. It further describes how Muller’s concept of X-ray mutagenicity sedimented through the adoption of X-ray machines as a ready-made resource for producing mutants by other geneticists, for instance George Beadle and Edward Tatum in their experiments on Neurospora crassa, despite ongoing disputes surrounding Muller’s conclusions. Technological sedimentation is proposed as a potential explanation why sedimentation and disputation may often coexist in the history of science. (shrink)

Abstract This article outlines Locke's theory of war as found in his political writings and seeks to redress a perceived imbalance in John Locke's morality of war. Locke's strident rejection of any sense of proportionality in warfare against unjust aggression, as read in the Second Treatise of Government, has to be tempered with his general philosophical programme against extremism of any sort. Arguably, Locke's war ethic when read alone is strict, objective, and emphatic, but when compared with his epistemological work, (...) its righteousness is reduced to extreme circumstances. (shrink)

National Book Award Finalist. How did humanity originate and why does a species like ours exist on this planet? Do we have a special place, even a destiny in the universe? Where are we going, and perhaps, the most difficult question of all, "Why?" In The Meaning of Human Existence, his most philosophical work to date, Pulitzer Prize–winning biologist Edward O. Wilson grapples with these and other existential questions, examining what makes human beings supremely different from all other species. (...) Searching for meaning in what Nietzsche once called "the rainbow colors" around the outer edges of knowledge and imagination, Wilson takes his readers on a journey, in the process bridging science and philosophy to create a twenty-first-century treatise on human existence—from our earliest inception to a provocative look at what the future of mankind portends. Continuing his groundbreaking examination of our "Anthropocene Epoch," which he began with The Social Conquest of Earth, described by the New York Times as "a sweeping account of the human rise to domination of the biosphere," here Wilson posits that we, as a species, now know enough about the universe and ourselves that we can begin to approach questions about our place in the cosmos and the meaning of intelligent life in a systematic, indeed, in a testable way. Once criticized for a purely mechanistic view of human life and an overreliance on genetic predetermination, Wilson presents in The Meaning of Human Existence his most expansive and advanced theories on the sovereignty of human life, recognizing that, even though the human and the spider evolved similarly, the poet's sonnet is wholly different from the spider's web. Whether attempting to explicate "The Riddle of the Human Species," "Free Will," or "Religion"; warning of "The Collapse of Biodiversity"; or even creating a plausible "Portrait of E.T.," Wilson does indeed believe that humanity holds a special position in the known universe. The human epoch that began in biological evolution and passed into pre-, then recorded, history is now more than ever before in our hands. Yet alarmed that we are about to abandon natural selection by redesigning biology and human nature as we wish them, Wilson soberly concludes that advances in science and technology bring us our greatest moral dilemma since God stayed the hand of Abraham. (shrink)

Rowan Williams's theological-moral reasoning regarding the formation of personal identities in relation to gender, familial and communal ties is analysed in an article review of his book Lost Icons. This is his most sustained essay in theological social criticism, and was intended for the general public beyond academic theology. Williams exposes Christian moral reasoning on these issues to forms of secular critique whilst simultaneously using theological and historical strategies from liberal Anglo-Catholicism. His argumentation is subjected to theological and social-scientific scrutiny. (...) The article calls for closer attention to debates within secular feminism and social research concerning the formation of adult men and women in relation to the wider post-Christian society. Links are made from Williams's thought in Lost Icons to underlying patterns in his academic theological output. (shrink)

Presenting a landmark in linguistics and cognitive science, Ray Jackendoff proposes a new holistic theory of the relation between the sounds, structure, and meaning of language and their relation to mind and brain. Foundations of Language exhibits the most fundamental new thinking in linguistics since Noam Chomsky's Aspects of the Theory of Syntax in 1965—yet is readable, stylish, and accessible to a wide readership. Along the way it provides new insights on the evolution of language, thought, and communication.

Science provides us with representations of atoms, elementary particles, polymers, populations, genetic trees, economies, rational decisions, aeroplanes, earthquakes, forest fires, irrigation systems, and the world’s climate. It's through these representations that we learn about the world. This entry explores various different accounts of scientific representation, with a particular focus on how scientific models represent their target systems. As philosophers of science are increasingly acknowledging the importance, if not the primacy, of scientific models as representational units of science, it's important to (...) stress that how they represent plays a fundamental role in how we are to answer other questions in the philosophy of science (e.g. the scientific realism debate). This entry begins by disentangling ‘the’ problem of scientific representation, before critically evaluating the current options available in the literature. (shrink)

This is a book grounded in the real ethical challenges of modern business practice, with a world-religious perspective so necessary in an era of globalization.

The so-called ergodic hierarchy (EH) is a central part of ergodic theory. It is a hierarchy of properties that dynamical systems can possess. Its five levels are egrodicity, weak mixing, strong mixing, Kolomogorov, and Bernoulli. Although EH is a mathematical theory, its concepts have been widely used in the foundations of statistical physics, accounts of randomness, and discussions about the nature of chaos. We introduce EH and discuss its applications in these fields.

Ludwig Wittgenstein is perhaps the greatest philosopher of the twentieth century, and certainly one of the most original in the entire Western tradition. Given the inaccessibility of his work, it is remarkable that he has inspired poems, paintings, films, musical compositions, titles of books -- and even novels. In his splendid biography, Ray Monk has made this very compelling human being come alive in a way that perfectly explains the fascination he has evoked. Wittgenstein's life was one of great moral (...) and spiritual depth. Although his work addresses problems of logic, language, mind, and knowledge, he often described it as having an ethical point, and once said that he "could not help seeing every problem from a religious point of view." In successfully bridging the gap assumed by many to exist between Wittgenstein's life and his work, Monk's biography helps to explain the interest in Wittgenstein's later philosophy on the part of Buddhist scholars. (shrink)