Whoever compares the genomes of distantly related species might find aberrantly high sequence similarity at certain loci. Such anomaly can only be explained by genetic material being transferred through other means than reproduction, that is, a horizontal transfer. Between multicellular organisms, the transferred material will likely turn out to be a transposable element. Because TEs can move between loci and invade chromosomes by replicating themselves, HT of TEs profoundly impacts genome evolution. Yet, very few studies have quantified HTT at large (...) taxonomic scales. Indeed, this task currently faces difficulties that range from the variable quality of available genome sequences to limitations of analytical procedures, some of which have been overlooked. Here we review the many challenges that an extensive analysis of HTT must overcome, we expose biases and limits of current methods, suggest solutions or workarounds, and reflect upon approaches that could be developed to better quantify this phenomenon. With the large amount of genomic resources now available, horizontal transfer of transposable elements can be studied as an evolutionary process, rather than as isolated cases. We discuss some of the difficulties encountered in detecting and counting such transfers and propose guidelines and directions for future research in this area. (shrink)

Ethics and the Clinical Encounter explores the moral dimensions of clinical medicine and the phenomenon of illness, to determine what ethics must be in order to be fully responsive to clinical encounters. Written in a lively and conversational style with minimal technical terminology, and enhanced by actual experience or real clinical situations, this volume lays out a clinical ethics methodology both in practical and theoretical terms. Here's what the experts had to say: Professor Zaner has provided us with a remarkably (...) lucid and trenchant discussion of the interface of philosophy and the field of medicine. He brings into play an extraordinary range of historial knowledge, extensive observations based on firsthand experience with medical practices, and an acute sense of philosophical argumentation. This is a work that will be an exemplary and indispensable text in the philosophy of medicine for years to come. -- Calvin Schrag... it is a highly original contribution usable in a number of fields.... It really has no competition.... The genius of Zaner's approach is to ground ethics from the 'bottom up' and to direct us to the concrete particulars of therapeutic encounters wherein lie moral and ethical matters... meaty, challenging, and ultimately rewarding.... -- Paul R. Dokecki Richard M. Zaner founded the Center for Clinical and Research Ethics at Vanderbilt University Medical Center. Having established Vanderbilt's first Hospital Ethics Committee (1985), he served as co-chair of VUMC's Ethics Committee since its inception in 1990. Zaner has published five original books, edited ten, and translated four more, and has published more than 100 sections of books and professional journals. (shrink)

Introduction: The Anarchist -- The Minister: 1756-93 -- The Philosopher: 1793 -- The Activist: 1794-95 -- The Husband: 1796-99 -- The Educator: 1800-09 -- The Father:1810-19 -- The Pensioner:1819-36 -- The Legacy.

Early in the first volume of his Ideen zu einer reinen Phiinomeno logie und phiinomenologischen Philosophie, Edmund Husserl stated concisely the significance and scope of the problem with which this present study is concerned. When we reflect on how it is that consciousness, which is itself absolute in relation to the world, can yet take on the character of transcendence, how it can become mundanized, We see straightaway that it can do that only by means of a certain participation in (...) transcendence in the first, originary sense, which is manifestly the transcendence of material Nature. Only by means of the experiential relation to the animate organism does consciousness become really human and animal (tierischen), and only thereby does it achieve a place in the space and in the time of Nature. l Consciousness can become "worldly" only by being embodied within the world as part of it. In so far as the world is material Nature, consciousness must partake of the transcendence of material Nature. That is to say, its transcendence is manifestly an embodiment in a material, corporeal body. Consciousness, thus, takes on the characteristic of being "here and now" (ecceity) by means of experiential (or, more accurately, its intentive) relation to that corporeal being which embodies it. Accordingly, that there is a world for consciousness is a conse quence in the first instance of its embodiment by 2 that corporeal body which is for it its own animate organism. (shrink)

Philosophy and literature enjoy a close, complex relationship. Elucidating the connections between these two fields, this book examines the ways philosophy deploys literary means to advance its practice, particularly as a way of life that extends beyond literary forms and words into physical deeds, nonlinguistic expression, and subjective moods and feelings.

This honest, forthright, and beautifully-written book introduces readers to the human variations on medical topics spoken of in abstract in the daily news--euthanasia, assisted suicide, abortion, "extreme procedures", genetic testing, experimental surgeries--and to the people who must agonize over those decisions regarding themselves and their loved ones.

Current philosophies of art remain sadly dominated by visions of its end and lamentations of decline. Defining the very notions of art and the aesthetic as special products of Western modernity, they suggest that postmodern challenges to traditional high culture pose a devastating danger to Art's future. Richard Shusterman's new book cuts through the seductive confusions of these views by tracing the earthy roots of aesthetic experience and showing how the recent flourishing of aesthetic forms outside modernity's sacralized realm (...) of fine art evince the persistent presence of an artistic impulse far deeper and more durable than the modernist moment. Performing Live defends the abiding power of aesthetic experience by exploring its diverse roles, methods, and meanings, especially in fields marginal to traditional aesthetics but now most vibrantly alive in today's culture and new media. Ranging from rap, techno, and country music to cinema, cyberspace and urban design, Shusterman develops his radical theory of "somaesthetics," charting the complex network of bodily arts so prominent in contemporary life and self-styling. By blending concrete aesthetic analysis with insightful social critique, Shusterman, a well-known pragmatist philosopher, provides a rich menu and critical guide for today's pursuit of the art of living. (shrink)

Richard Rorty's collected papers, written during the 1980s and now published in two volumes, take up some of the issues which divide Anglo-Saxon analytic philosophers and contemporary French and German philosophers and offer something of a compromise - agreeing with the latter in their criticisms of traditional notions of truth and objectivity, but disagreeing with them over the political implications they draw from dropping traditional philosophical doctrines. The second volume pursues the themes of the first volume in the context (...) of discussions of recent European philosophy focusing on the work of Heidegger and Derrida. (shrink)

There have been few tests of whether exposure to naturalistic or experimental disease-threat inductions alter disgust sensitivity, although it has been hypothesized that this should occur as part of disgust’s disease avoidance function. In the current study, we asked Macquarie university students to complete measures of disgust sensitivity, perceived vulnerability to disease, hand hygiene behavior and impulsivity, during Australia’s Covid-19 pandemic self-quarantine period, in March/April 2020. These data were then compared to earlier Macquarie university, and other local, and overseas student (...) cohorts, to determine if disgust sensitivity and the other measures, were different in the lockdown sample. The most consistent finding in the lockdown sample was of higher core disgust sensitivity, with some evidence of greater germ aversion on the PVD, and an increase in hand and food-related hygiene, but with little change in impulsivity. The consistency with which greater core disgust sensitivity was observed, suggests exposure to a highly naturalistic disease threat is a plausible cause. Greater disgust sensitivity may have several functional benefits and may arise implicitly from the threat posed by the Covid-19 pandemic. (shrink)

This article presents findings from a new qualitative study of female offenders’ interactions with Nigerian policewomen. Against the position of policing literature and feminists and gender advocat...

When the modern artist is seen as moving about in a nebulous area between two opposing worlds, that of life or immediate experience and that of art or established truth, I think it is appropriate to discuss this activity in terms of metaphor. Indeed the present concern for metaphor in the academic and artistic communities is but one of many reflections of our sense that life is a process of the gradual attainment of knowledge through experience, whether sensuous or intellectual. (...) Like our artists, we strive to create a picture of our world, yet that picture is never complete; for we continually pass on to new experiences and new images of reality. Not only do we grow and change but our world seems to change with us. Although the truths revealed through our art are founded in our experience, they seem more permanent and public than the acts of discovery leading to them. A principle once established and integrated with a body of other established truths enters into recorded history perhaps to be revered, disputed, or reinterpreted, but nevertheless to remain. The individual experience or discovery, however, passes; with the individual, only the sense of the continuing search yields personal identity. In a changing world, metaphor renders the truth of experience as the truth of knowledge, for it is the means of passing from individual immediacy to an established public world; the new must be linked to the old, and the experience of any individual must be connected with that of his society. Excluding the possibility of the creation of entirely new worlds and the resultant transformation of all personal identities, acts of genius or dramatic breakthroughs in fields of study can affect our present world order only if they are joined to it by means of a powerful metaphor. Indeed establishing the metaphoric bridge itself may be considered the act of genius, and the entry into new areas of knowledge is its consequence. Richard Shiff is associate professor of art at the University of North Carolina at Chapel Hill. His contributions to Critical Inquiry are "Seeing Cézanne" and, with Carl Pletsch, "History and Innovation". (shrink)

RICHARD SHEDENHELM responds to Robert Campbell's essay, "Ayn Rand and the Cognitive Revolution in Psychology" . He identifies the most likely source of the crow-counting experiment cited at the beginning of chapter seven of Ayn Rand's Introduction to Objectivist Epistemology. He finds that the crow study was not at all an experiment, but instead an anecdotal account dating from the eighteenth-century French writer of animal behavior, Charles-Georges Leroy.

After a brief, personal reflection on Aron Gurwitsch's life and his many influences on my career, I devote this lecture to some of the central themes of a phenomenology of medicine. Its core is the clinical encounter, which displays a certain structure I term the asymmetry of power and vulnerability —a complex contextual imbalance characterized by multiple points of view, hence points for reflective entrance. These are then interpreted phenomenologically in terms of epoché and reduction, evidence, reflection, and other related (...) themes. I conclude with a suggestion about "the fundamental method" of phenomenology, free fantasy variation. (shrink)

Physicians have for some time been questioning the prevailing view of medicine as applied biology. It is urged that medicine needs to be reconceived so as to provide appropriate emphasis on the patient's experience and understanding of illness. After reviewing these arguments and the scientific paradigm underlying the received view in light of certain themes in medicine's history and of current thinking, Pellegrino's thesis is analyzed: medicine should be understood as an inherently moral enterprise, a form of praxis focused on (...) "the healing relationship". Understanding the illness experience and the professed healer's "compassion" supports Pellegrino's view, and suggests that the healing relationship is perhaps best conceived as a form of dialogue. Keywords: compassion, dialogue, healing relationship, illness experience, interpretation CiteULike Connotea Del.icio.us What's this? (shrink)

Reasoning can promote psychological development, so even if the role of philosophical counselor is defined strictly in terms of assisting the reasoning of the client, we can expect client-centered philosophical inquiry to yield psychological benefits. The practices of philosophical counseling and psychotherapy permeate one another to some degree while also diverging in characteristic focus. Philosophical counselors are particularly well suited to helping clients think through their situation in the world.

In his essay “Painting Memories” , Michael Fried identifies memory as the privileged thematic that structures Charles Baudelaire’s Salon of 1846. But he then limits his investigation of this topic by focusing on the representation of “past” art, to the exclusion of the recollection of “past” experience. Fried thus isolates the theme of memory from the dialectic of life and art that characterizes its performance for Baudelaire. Such selective analysis not only reverses Baudelaire’s priorities but deflects his pointed comments on (...) modernity and naiveté, which in turn inform the example of Edouard Manet, Fried’s exemplary modernist painter. One wonders whether too much of Baudelaire and Manet is lost to this view. Perhaps the predilections of contemporary criticism have sanctioned Fried’s approach. For today we hesitate to ground art in experience, preferring to conceive of representations as signs fully engendered by and engendering other signs. Baudelaire was of a different mind; he lived through the dawning of our own age, but also in the fading light of another. He was heir to a tradition that regarded the forms of art as powerfully motivated by the experience of internalized ideas and sensations; for him, a master artist’s “signs” would appear more symbolic than allegorical, more immediate than mediated or distanced. As we deny artistic signs motivation in extralinguistic “experience,” we aggravate that perennial problem of origins which Fried himself invokes. It might be reformulated in this manner: all painting depends on a lineage of antecedent painting; yet, to succeed, a new work must transcend its filial bondage, as it compounds the effect of the “original” in its own originality. Vexation follows from this issue of the artistic source. Since memories of past art make possible the very creation of art, the creative event cannot assume priority over memory. And the matter of primordial memory, like the matter of an absolutely original art, is aporia. Fried does not pursue this matter ; but the question necessarily implies that both representations and memories, in constituting the “past,” must always be distanced. Distanced not from the present, which they enter and likewise constitute, but from those “original” experiential moments they purport to present. Richard Schiff is associate professor of art at the University of North Carolina at Chapel Hill. He is the author of Cézanne and the End of Impressionism: A Study of the Theory, Technique, and Critical Evaluation of Modern Art and is currently working on a study of modernism in relation to classicism and a related study of photographic realism. His previous contributions to Critical Inquiry are “Seeing Cézanne” , “Art and Life: A Metaphoric Relationship” , and, with Carl Pletsch, “History and Innovation”. (shrink)

A discussion of Aristotle’s thought on determinism and culpability, Necessity, Cause, and Blame also reveals Richard Sorabji’s own philosophical commitments. He makes the original argument here that Aristotle separates the notions of necessity and cause, rejecting both the idea that all events are necessarily determined as well as the idea that a non-necessitated event must also be non-caused. In support of this argument, Sorabji engages in a wide-ranging discussion of explanation, time, free will, essence, and purpose in nature. He (...) also provides historical perspective, arguing that these problems remain intimately bound up with modern controversies. “ Necessity, Cause and Blame would be counted by all as one of Sorabji’s finest. The book is essential for philosophers—both specialists on the Greeks and modern thinkers about free will—and also compelling for non-specialists.”—Martha Nussbaum “Original and important . . . The book relates Aristotle’s discussions to both the contemporary debates on determinism and causation and the ancient ones. It is especially detailed on Stoic arguments about necessity . . . and on the social and legal background to Aristotle’s thought.”— Choice “It is difficult to convey the extraordinary richness of this book. . . . A Greekless philosopher could read it with pleasure . . . At the same time, its learning and scholarship are enormous.”—G. E. M. Anscombe, Times Literary Supplement. (shrink)

In Liberalism and Pluralism, Richard Bellamy explores the challenges posed by conflicting values, interests and identities to liberal democracy. Conventional liberal thought is no longer suited to the complex, plural societies of today. By analyzing the three major strands of liberal thought as represented by Hayek, Rawls and Walzer, the author reveals how standard liberalism has tried to circumvent unstable settlements. This book establishes a more satisfactory alternative: namely, negotiated compromise.

The political passages in Polanyi’s Personal Knowledge are an integral part of his arguments against ‘objectivism’ and/or a post-critical, personalist, fiduciary and fallibilist philosophy. This paper elaboratesthe social and political implications of Polanyi’s emphasis upon acceptance of one’s situation and the exercise in it of a sense of responsibility to transcendent ideals, as against attempts to start with a clean slate, to overcome all imperfections and to find some simple rule for political policy. Prescriptive duties and rights, and mutual trust (...) and solidarity, are the bases of politics, anti responsible action must start with them. But much of modern politics expresses a Gnostic impatience of our created and finite existence which results in arbitrary commitment to some radical and destructive ideology. (shrink)

Applying contemporary pragmatism to the crucial question of how philosophy can help us live better, Shusterman develops his distinctive aesthetic model of philosophical living that includes politics, somatics, and ethnicity, while critically engaging the rival views of Dewey, Wittgenstein, and Foucault, as well as Rorty, Putnam, Goodman, Habermas, and Cavell.

Nationalism has become a contested construct because scholars doubt its ideological authenticity and global migratory consciousness, which promotes transcultural / transnational identity, and problematizes its raison d’être. Though Abouet and Oubrerie’s graphic novel could be read as a portrayal of the emerging urban center and its postmodern identities, this study rather investigates how Aya de Yopougon galvanizes juvenile nationalistic consciousness through age-long African communal identity. Using the postcolonial theory, the paper argues that the epistemology of nationalism, as a forerunner of (...) nationhood, has been inherently encapsulated in African communal identity as manifested in the lives of middle-class dwellers of Yopougon, a suburb of Abidjan. It further deconstructs the symbolic Eurocentric paradigms of nationalism because nationalistic consciousness is located in the African definition of “family” and “community” revealed in the setting of Yopougon which contrasts with other spaces that bear the emblem of nationhood in the novel. Yopougon is not Anderson’s “imagined community”; its inhabitants reflect African communal identity that is located in gender complementarities and civic interdependence. The paper concludes that communalism could be an African brand of modern nationalism, used to develop the nationalistic and communalistic consciousness of the Ivorian youths who are faced with crude realities of a postcolonial society. (shrink)

The introduction discusses the influence of two kinds of philosophy to film theory. It describes and clarifies the characteristic methods and strategies of analytic philosophy and film theory, and continental philosophy and film theory. It is concerned with the description of methods, debates, and principles of analytic philosophy with reference to the contributions of philosophy to film theory. It informs and provides indication of issues, methods, and doctrines. It examines, criticizes, and defends the use of exponents of analytic and continental (...) philosophy. All throughout the introduction, it is noted that analytic philosophy is conceived as a pedantic, conservative discipline by scholars of film, media, and culture while continental philosophy is seen as having more imaginative richness and being more focused on moral and ideological issues. However, the aim of analysing film theory is not to stop the pursuit of any specific doctrine but to improve the rigor with its pursuit. (shrink)

This chapter enquires into the nature of university teaching. I consider whether Alasdair MacIntyre's notion of a practice, together with some of his related ideas, is useful to us here. My argument is that MacIntyre's talk of incommensurable rationalities tells in the end against the fragmentation of higher education and rather points to one distinctive and important role for the university: that the university should be conceived in some respects as a therapeutic community, whose function it is to encourage and (...) enable its members to think together. (shrink)

This chapter enquires into the nature of university teaching. I consider whether Alasdair MacIntyre’s notion of a practice, together with some of his related ideas, is useful to us here. My argument is that MacIntyre’s talk of incommensurable rationalities tells in the end against the fragmentation of higher education and rather points to one distinctive and important role for the university: that the university should be conceived in some respects as a therapeutic community, whose function it is to encourage and (...) enable its members to think together. (shrink)