A general framework by which dynamic interactions within a protein will promote the necessary series of structural changes, or “conformational cycle,” required for function is proposed. It is suggested that the free‐energy landscape of a protein is biased toward this conformational cycle. Fluctuations into higher energy, although thermally accessible, conformations drive the conformational cycle forward. The amino acid interaction network is defined as those intraprotein interactions that contribute most to the free‐energy landscape. Some network connections are consistent in every structural (...) state, while others periodically change their interaction strength according to the conformational cycle. It is reviewed here that structural transitions change these periodic network connections, which then predisposes the protein toward the next set of network changes, and hence the next structural change. These concepts are illustrated by recent work on tryptophan synthase. Disruption of these dynamic connections may lead to aberrant protein function and disease states. (shrink)

The digital shift leads to increasing changes. Employees can deal with changes through informal learning that enables needs-based development. For successful informal learning, self-regulated learning is crucial, i.e., to set goals, plan, apply strategies, monitor, and regulate learning for example by applying resource strategies. However, existing SRL models all refer to formal learning settings. Because informal learning differs from formal learning, this study investigates whether SRL models can be transferred from formal learning environments into informal work settings. More precisely, are (...) all facets relevant, and what are the relational patterns? Because informal workplace learning occurs through interaction with the context, this study investigates the influence of context, i.e., organizational learning culture and job characteristics on SRL. Structural equation modeling of N = 170 employees in various industries showed the relevance of the self-reported metacognitive strategies planning, monitoring, and regulation; the resource strategies help-seeking and effort regulation; and deep processing strategy elaboration. However, there was no evidence for organization strategies. The learning strategies were associated with self-efficacy and mastery-approach goal orientation. Regarding context, results supported indirect effects over self-motivational beliefs of learning strategies. Organizational learning culture was connected with mastery-approach goal orientation, whereas job characteristics autonomy and feedback were related to self-efficacy, which were again related to SRL strategies. Therefore, context can empower employees not only to accomplish their tasks but to develop themselves by applying SRL strategies. The results are discussed, and practical implications are outlined. (shrink)

We examine the sequences A that are low for dimension, i.e. those for which the effective dimension relative to A is the same as the unrelativized effective dimension. Lowness for dimension is a weakening of lowness for randomness, a central notion in effective randomness. By considering analogues of characterizations of lowness for randomness, we show that lowness for dimension can be characterized in several ways. It is equivalent to lowishness for randomness, namely, that every Martin-Löf random sequence has effective dimension (...) 1 relative to A, and lowishness for K, namely, that the limit of KA/K is 1. We show that there is a perfect [Formula: see text]-class of low for dimension sequences. Since there are only countably many low for random sequences, many more sequences are low for dimension. Finally, we prove that every low for dimension is jump-traceable in order nε, for any ε > 0. (shrink)

BackgroundStory recall tests have shown variable sensitivity to rate of cognitive decline in individuals with Alzheimer’s disease biomarkers. Although SR tasks are typically scored by obtaining a sum of items recalled, item-level analyses may provide additional sensitivity to change and AD processes. Here, we examined the difficulty and discrimination indices of each item from the Logical Memory SR task, and determined if these metrics differed by recall conditions, story version, lexical categories, serial position, and amyloid status.Methodsn = 1,141 participants from (...) the Wisconsin Registry for Alzheimer’s Prevention longitudinal study who had item-level data were included in these analyses, as well as a subset of n = 338 who also had amyloid positron emission tomography imaging. LM data were categorized into four lexical categories, and by serial position. We calculated difficulty and discriminability/memorability by item, category, and serial position and ran separate repeated measures ANOVAs for each recall condition, lexical category, and serial position. For the subset with amyloid imaging, we used a two-sample t-test to examine whether amyloid positive and amyloid negative groups differed in difficulty or discrimination for the same summary metrics.ResultsIn the larger sample, items were more difficult in the delayed recall condition across both story A and story B. Item discrimination was higher at delayed than immediate recall, and proper names had better discrimination than any of the other lexical categories or serial position groups. In the subsample with amyloid PET imaging, proper names were more difficult for Aβ+ than Aβ−; items in the verb and “other” lexical categories and all serial positions from delayed recall were more discriminate for the Aβ+ group compared to the Aβ− group.ConclusionThis study provides empirical evidence that both LM stories are effective at discriminating ability levels and amyloid status, and that individual items vary in difficulty and discrimination by amyloid status, while total scores do not. These results can be informative for the future development of sensitive tasks or composite scores for early detection of cognitive decline. (shrink)

L'explosion depuis plus d'une vingtaine d'années maintenant du nombre de travaux historiques portant sur les femmes ou « le genre » n'a touché que tardivement le continent africain. Les chercheurs anglophones ont amorcé cependant un mouvement qui ne cesse de susciter de nouvelles recherches. Cette réflexion, à la croisée de l'histoire des missionnaires, de l'histoire des femmes et de l'histoire coloniale, a profondément renouvelé les connaissances et la compréhension de la place des fe...

L'explosion depuis plus d'une vingtaine d'années maintenant du nombre de travaux historiques portant sur les femmes ou « le genre » n'a touché que tardivement le continent africain. Les chercheurs anglophones ont amorcé cependant un mouvement qui ne cesse de susciter de nouvelles recherches. Cette réflexion, à la croisée de l'histoire des missionnaires, de l'histoire des femmes et de l'histoire coloniale, a profondément renouvelé les connaissances et la compréhension de la place des fe...

Quatre ans après le numéro « Voyageuses » de Clio HFS (n° 38, 2008), un collectif d’historien-ne-s de la littérature livre dans cet ouvrage une réflexion sur les spécificités du récit de voyage féminin. Sans rechercher l’existence d’une écriture féminine, et loin de tout « dogmatisme théorique », écrit la quatrième de couverture, les auteur-e-s analysent les écrits de voyageuses qui font dorénavant partie d’un canon féminin d’écritures viatiques en langues anglaise, française et allemande. Du...

REBECCA TUVEL,VINCENT DUHAMEL | : La tentative de l’ancienne cheffe d’une section de la NAACP 1 Rachel Dolezal de passer de la race blanche à la race noire a occasionné une intense controverse. Son histoire est devenue célèbre au même moment où Caitlyn Jenner2 faisait la couverture de Vanity Fair, signe d’une acceptation grandissante de l’identité trans. Pourtant, les critiques adressées à Dolezal pour avoir caché sa race natale indiquent qu’il existe une perception sociale largement répandue selon laquelle il (...) n’est ni possible ni acceptable de changer de race de la manière dont on peut changer de sexe. Les considérations qui soutiennent le transgenrisme3 semblent s’appliquer également au transracialisme. Que Dolezal représente ou non un exemple authentique de personne transraciale, son histoire et la réaction publique qu’elle a suscitée peuvent fournir un cas instructif à étudier. | : Former NAACP chapter head Rachel Dolezal’s attempted transition from the white to the black race occasioned heated controversy. Her story gained notoriety at the same time that Caitlyn Jenner graced the cover of Vanity Fair, signaling a growing acceptance of transgender identity. Yet criticisms of Dolezal for misrepresenting her birth race indicate a widespread social perception that it is neither possible nor acceptable to change one’s race in the way it might be to change one’s sex. Considerations that support transgenderism seem to apply equally to transracialism. Although Dolezal herself may or may not represent a genuine case of a transracial person, her story and the public reaction to it serve helpful illustrative purposes. (shrink)

A critical account of the case for historicism from Popper to Foucault, this volume, originally published in 1989, shows the viability of an historicist account of knowledge by replying to traditional objections and the need for defenses of realism and reference at the heart of most alternatives to historicism. The book provides insights to those in philosophy as well as literary criticism, intellectual history, history of science, and cultural criticism.

The proportionality standard demands a meaningful link between the severity of crimes and the punishments received for them. This article investigates the compatibility between this philosophical demand and the practical means most commonly associated with criminal justice provision: governmental decision making. In so far as criminal justice systems require the coordination of real human and physical resources, certain forms of knowledge and incentives are required to calculate, produce, and distribute outputs proportionately. Whereas markets rely upon pricing mechanisms to generate and (...) coordinate information and incentives across diverse stages of complex production processes, governmental decision making often lacks a calculation mechanism comparable to market prices through which knowledge about societal needs and demands can be conveyed and may thus inevitably result in some forms of punitive disparity. (shrink)

A critical account of the case for historicism from Popper to Foucault, this volume, originally published in 1989, shows the viability of an historicist account of knowledge by replying to traditional objections and the need for defenses of realism and reference at the heart of most alternatives to historicism. The book provides insights to those in philosophy as well as literary criticism, intellectual history, history of science, and cultural criticism.

My review of Cornelius Castoriadis' book Crossroads in the Labyrinth ended with the apt reference, I now see, to the emperor being naked. In Joel Whitebook's second review, largely irrelevant to my criticisms of Castoriadis, he fears, though he doesn't know me personally, that only the lack of psychological counseling can explain my uncontrolled anger against Castoriadis. Let me dignify his long distance psychoanalysis by passing over it in silence. Silence is also the best remedy for Whitebook's transcendental deduction that (...) I have a “pluralistic, localistic, discontinuous ontology.” Even if I knew what that was I find it amazing that he located it in a 10 page review. Perhaps Whitebook just “feels” the presence of this ontology along with evidence of my mental problems. (shrink)

, Lawrie Reznek argues that disease is not a natural kind term. I raise objections to Reznek's two central arguments for establishing that disease is not a natural kind. In criticizing his a priori, conceptual argument against naturalism, I argue that his conclusion rests on a weaker argument that appeals to the empirical diversity in the symptoms and manifestations of disease. I also raise questions about the account of natural kinds which Reznek utilizes and his point that conventions for classification (...) are excluded by there being natural kinds. Keywords: Disease, natural kind, value judgement CiteULike Connotea Del.icio.us What's this? (shrink)

Contemporary Continental Philosophy steps back from current debates comparing Continental and analytic philosophy and carefully, yet critically outlines the tradition’s main philosophical views on epistemology and ontology. Forgoing obscure paraphrases, D’Amico provides a detailed, clear account and assessment of the tradition from its founding by Husserl and Heidegger to its challenge by Derrida and Foucault. Though intended as a survey of this tradition throughout the twentieth century, this study’s focus is on the philosophical problems which gave it birth and even (...) now continue to shape it.The book reexamines Husserl as an early critic of epistemological naturalism whose grasp of the philosophical importance of the theory of meaning was largely ignored. Heidegger’s contrasting effort to revive ontology is examined in terms of his distinction between ontic and ontological questions. In contrast with many earlier studies, the author outlines confusions engendered by the misappropriation of the distinct philosophical agendas of Husserl and Heidegger by such famous figures as Sartre and Merleau-Ponty. The book is also original in its emphasis on how social externalism in epistemology, inspired by Karl Mannheim, influenced this tradition’s structuralist and Marxist phases. The philosophical defenses of a theory of interpretation by Gadamer and Habermas are closely examined and assessed and the study concludes with a a probing yet balanced account of Foucault and Derrida as critics of philosophical autonomy. The book concludes by reassessing this century-long divide between the analytic and Continental traditions and its implication for the future of philosophy. (shrink)

This writer who has warned us of the “ideological” function of both the oeuvre and the author as unquestioned forms of discursive organization has gone quite far in constituting for both these “fictitious unities” the name (with all the problems of such a designation) Michel Foucault. One text under review, La Volonté de Savoir, is the methodological introduction of a projected five-volume history of sexuality. It will apparently circle back over that material which seems to have a special fascination for (...) Foucault: the gradual emergence of medicine as an institution, the birth of political economy, demography and linguistics as “human sciences,” the invention of incarceration and confinement for the control of the “other” in society (the mad, the libertine, the criminal) and that special violence that lurks beneath the power to control discourse. (shrink)

What roles do women play in world politics? Who are these women, and what impact do they have on international relations? D'Amico and Beckman have assembled a diverse array of contributors who provide a variety of answers. Some contributors consider women as national leaders and profile Chamorro, Gandhi, Thatcher, and Aquino as examples. Autobiographical essays and interviews describe the experiences of Margaret Anstee, Benazir Bhutto, Jeane Kirkpatrick, and Golda Meir. Other contributors analyze international women's movements, the roles of women in (...) the Green Movement and in the revolutionary movements in Cuba and Nicaragua, and the work of Jane Addams in the peace movement. Some analyze the attitudes and beliefs of America's leading opinion makers on the subject of women and men in leadership roles. Written for beginning students in comparative politics and international relations, their work is both fundamental as an introductory text and pioneering in scope and conception. (shrink)

Este artículo analiza el contexto en el que surge la Universidad en el occidente latino medieval y en ese marco la teorización y profesionalización de la filosofía. Por otra parte, expone de qué manera esta profesionalización impone su propia negación como la filosofía en lengua vulgar y los saberes no universitarios. Finalmente, reflexiona sobre la Universidad hoy.

Title: The Common Mind: An Essay on Psychology, Society, and PoliticsPublisher: Oxford University PressISBN: 0195106458Author: Philip PettitTitle: Republicanism: A Theory of Freedom and GovernmentPublisher: Oxford University PressISBN: 0198296428Author: Philip Pettit.

The article analizes the several times of Proclus‘s reception by Nicholas of Cusa’s thought. The direct reading of Proclus can be established because Expositio in Parmenidem Platonis –Cod.Cus. 186– and Elementatio theological –Cod.Cus.195– (Moerbeke’s translation) and De theologia Platonis Libri VI –Cod.Cus.185– (Petrus Balbus’s translation) are in his Library in Bernkastel-Kues with his marginalia. The assimilation of doctrines can be considered assuming that the implicits and explicits references to Plato’s Diadochus, especially in the last works.

Title: Discipline and PunishPublisher: Pantheon booksISBN: 978-0394499420Author: Michel FoucaultTitle: Language, Counter-Memory, PracticePublisher: Wiley-BlackwellISBN: 978-0631182405Author: Michel FoucaultTitle: La Volonte de SavoirPublisher: GallimardAuthor: Michel FoucaultTitle: Oublier FoucaultPublisher: Editions GalileeISBN: 978-2718600604Author: Jean Baudrillard.

This article concerns the metaphysics of disease. Is disease a fixed feature of the world or a social value or preference? I argue that disease is not a value-laden concept and thus debates concerning it differ fundamentally from debates concerning health, harm, or suffering where evaluative judgements are central. I show how the so-called social constructionist view of disease has been motivated both by ethical concerns with medical practices and general theoretical doubts about scientific naturalism. If I can show that (...) ethical concerns about medical treatment can be answered without adopting social constructionism, that leaves only the broader theoretical question of naturalism. I cannot completely answer those theoretical doubts, but I show that the theoretical motivation is less convincing when it is separated from the moral challenge often accompanying it. I conclude that a convincing defense of the non-naturalistic conception of disease is rarely attempted and proves more difficult and counter-intuitive than its proponents assume. (shrink)

This volume contains an essay by Martha Nussbaum in defense of world citizenship or “cosmopolitanism,” as opposed to patriotism, which she defines as any view treating “national boundaries as morally salient,” together with a series of brief supportive (Anthony Appiah and Amartya Sen) and critical (Benjamin Barber, Gertrude Himmelfarb, Hilary Putnam, Immanuel Wallerstein, and Michael Walzer, et al.) comments. The essay originally appeared in The Boston Review in 1994 and led to bringing together the “usual suspects” for a bit of (...) popular edification and policy-making. Such posturing by what passes today for public intellectuals is rarely successful and not always…. (shrink)