The goal of this paper is two-fold: first, to emphasize causality in disease ontology and knowledge representation, presenting a general and cursory discussion of causality and causal chains; and second, to clarify and develop the River Flow Model of Diseases (RFM). The RFM is an ontological account of disease, representing the causal structure of pathology. It applies general knowledge of causality using the concept of causal chains. The river analogy of disease is explained, formal descriptions are offered, and the RFM (...) disease definition is refined by describing causal chains in terms of causal relations. The definition is updated to coincide with the actual RFM classes found in its upper-level ontology, YAMATO, which brings to light some challenges in developing both YAMATO and the RFM. The RFM is also discussed in relation to another ontological account of disease. Strategies are offered toward interoperability between these theories. (shrink)

The ethics of artificial intelligence (AI) is a research topic with both theoretical and practical significance. However, the ethical and moral aspects of conceptual, ontological, semantic, and knowledge modeling, more specifically, and which are sometimes found in AI applications, is not being given sufficient attention. I argue that it should. Whether considering using or developing these meaning-focused models, there are ethical aspects. This paper offers a preliminary outline about this potentially new research field, discussing: some questions and areas of concern, (...) their significance; scenarios of ethical import, and initial ethical guidelines. A focus area, potential case study, and lens through which to see the ethical significance at hand, is ontologies, with emphasis on the most abstract ontologies (so-called generic, foundational, top-level or upper ontologies). This would aim to show the ethical import of highly abstract (often philosophical) ontological choices, assumptions, and their effects on data, developers, users, and society. In particular, I stress the need for critical examination of such models, their content, their intended meanings, assumptions, ideologies, as well as the development process. Both the ethics of, and ethics in, these activities are, therefore, of interest. Topics in the ethics of AI that are relevant include: transparency, bias, data-sharing, privacy, control over data, etc. This paper thereby contributes to the ethics of AI, as well as the ethics of information, of knowledge managment and relevant topics by developing and discussing the ethics of ontology (and similar systems). Future development will refine and add to the ideas expressed in this paper. (shrink)

In “A Defense of Presentism ”, Ned Markosian addresses the problem of singular propositions about non-present objects. The proposed solution uses a paraphrasing strategy that differentiates between two kinds of meaning in declarative sentences, and also distinguishes between two truth-conditions for singular propositions. The solution, however, is unsatisfactory. I demonstrate that the both truth-conditions suffer from the same problems in spite of the examples used to support the claim that one is a proper treatment for singular propositions. Part of the (...) difficulty is in the limited expressivity of logical formalisms, a limitation not unique to the philosophy of time, but which calls for greater attention. (shrink)

A sourcebook for developing and facilitating collaborative groups capable of continuously adapting to anticipate the evolving learning needs of students. Based on a theoretical foundation of schools as complex systems in which linear management models are no longer sufficient.

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

This collection of 21 essays explores the creative interaction among the cognitive neurosciences, philosophy, and theology. It is the result of an international research conference co-sponsored by the Vatican Observatory, Rome, and the Center for Theology and the Natural Sciences, Berkeley.

This work, first published in 1985, offers a general interpretation of Hume's Treatise of Human Nature. Most Hume scholarship has either neglected or downplayed an important aspect of Hume's position - his scepticism. This book puts that right, examining in close detail the sceptical arguments in Hume's philosophy.

Chapter III contains several puzzles and unexpected features. The first puzzle regards the chapter’s relationship to Chapter IV: Natural Selection. Both chapters treat of natural selection, so what distinguishes them? Is it that Chapter IV indicates the intelligence behind nature’s selections and Chapter III introduces the analog of intelligence? And is it that Chapter III suggests that natural selection performs an eliminative function, while Chapter IV shows the positive impact of selection? In Chapter IV, and in many subsequent chapters, natural (...) selection, Darwin says, operates only for the good of each individual creature, though Chapter III suggests it destroys most individuals. Darwin asserts that he uses the term “struggle” metaphorically, which raises the question of the explanatory weight his metaphors carry, such metaphors as "the face of nature.” There are a number of unexpected features of Darwin’s analysis displayed in the chapter: for example, his introduction of a new concept of the selective environment and the several experiments he performs to establish his theory, e.g., from mathematical and thought experiments to controlled empirical experiments. Chapter III is a rich though puzzling chapter. (shrink)

Of knowledge and probability: a quick tour of part 3, book 1. Of knowledge ; Of probability; and of the idea of cause and effect ; Why a cause is always necessary? ; Of the component parts of our reasonings concerning causes and effects ; Of the impressions of the senses and memory ; Of the inference from the impression to the idea ; Of the nature of the idea, or belief ; Of the causes of belief ; Of the (...) effects of other relations, and other habits ; Of the influence of belief ; Of the probability of chances ; Of the probability of causes ; Of unphilosophical probability ; Of the idea of necessary connexion ; Rules by which to judge of causes and effects ; Of the reason of animals -- Hume on unphilosophical probabilities -- Hume's skepticism with regard to reason -- Of skepticism with regard to the senses -- Of the ancient and modern philosophy -- The soul and the self -- The conclusion of book 1 -- Two openings and two closings. (shrink)

The principle of the child's right to an open future was first proposed by the legal philosopher Joel Feinberg and developed further by bioethicist Dena Davis. The principle holds that children possess a unique class of rights called rights in trust—rights that they cannot yet exercise, but which they will be able to exercise when they reach maturity. Parents should not, therefore, take actions that permanently foreclose on or pre-empt the future options of their children, but leave them the greatest (...) possible scope for exercising personal life choices in adulthood. Davis particularly applies the principle to genetic counselling, arguing that parents should not take deliberate steps to create physically abnormal children, and to religion, arguing that while parents are entitled to bring their children up in accordance with their own values, they are not entitled to inflict physical or mental harm, neither by omission nor commission. In this paper, I aim to elucidate the open future principle, and consider whether it is applicable to non-therapeutic circumcision of boys, whether performed for cultural/religious or for prophylactic/health reasons. I argue that the principle is highly applicable to non-therapeutic circumcision, and conclude that non-therapeutic circumcision would be a violation of the child's right to an open future, and thus objectionable from both an ethical and a human rights perspective. (shrink)

This book is a small handbook designed to give Institutional Review Board (IRB) members the information they need to protect the rights and welfare of research subjects in a way that is both effective and efficient. The chapters of this book are short and to the point. Topic-specific chapters list the criteria IRB members should use to determine how to vote on specific kinds of studies and offer practical advice on what IRB members should do before and during full-committee meetings.

In this book, Dr. Robert J. Levine reviews federal regulations, ethical analysis, and case studies in an attempt to answer these questions.

"All art should become science and all science art; poetry and philosophy should be made one." Friedrich Schlegel's words perfectly capture the project of the German Romantics, who believed that the aesthetic approaches of art and literature could reveal patterns and meaning in nature that couldn't be uncovered through rationalistic philosophy and science alone. In this wide-ranging work, Robert J. Richards shows how the Romantic conception of the world influenced (and was influenced by) both the lives of the people (...) who held it and the development of nineteenth-century science. Integrating Romantic literature, science, and philosophy with an intimate knowledge of the individuals involved—from Goethe and the brothers Schlegel to Humboldt and Friedrich and Caroline Schelling—Richards demonstrates how their tempestuous lives shaped their ideas as profoundly as their intellectual and cultural heritage. He focuses especially on how Romantic concepts of the self, as well as aesthetic and moral considerations—all tempered by personal relationships—altered scientific representations of nature. Although historians have long considered Romanticism at best a minor tributary to scientific thought, Richards moves it to the center of the main currents of nineteenth-century biology, culminating in the conception of nature that underlies Darwin's evolutionary theory. Uniting the personal and poetic aspects of philosophy and science in a way that the German Romantics themselves would have honored, The Romantic Conception of Life alters how we look at Romanticism and nineteenth-century biology. (shrink)

following list of abbreviations : Ethics — Lectures on Ethics GMM — Groundwork of the Metaphysic of Morals KrV — Critique of Pure Reason KU — Critique of ...

How are dependent (or linked) premises to be distinguished from independent (or convergent) premises? Deductive validity, sometimes proposed as a necessary condition for depende'nce, cannot be, for the premises of both inductive and deductive but invalid arguments can be dependent. The question is really this: When do multiple premises for a certain conclusion fonn one argument for that conclusion and when do they form multiple arguments? Answer: Premises are dependent when the evidence they offer for their conclusion is more than (...) the ordinary sum of their probabilities. Ordinary sums are defined in the paper. (shrink)

The evolutionary origin of human pair-bonds is uncertain. One hypothesis, supported by data from forgers, suggests that pair-bonds function to provision mothers and dependent offspring during lactation. Similarly, public health data from large-scale industrial societies indicate that single mothers tend to wean their children earlier than do women living with a mate. Here we examine relations between pair-bond stability, alloparenting, and cross-cultural trends in breastfeeding using data from 58 “traditional” societies in the Standard Cross-Cultural Sample (SCCS). Analyses show that stable (...) conjugal relationships were associated with significantly later weaning among the societies in the SCCS. The relationship between pair-bond stability and age at weaning was not mediated by women’s ability to provision themselves or women’s kin support. Availability of alloparental care was also inversely related to age at weaning, and the association was not significantly reduced after controlling for frequency of divorce. This study indicates that among a woman’s kin relationships, a pair-bond with a child’s father is especially supportive of breastfeeding. These cross-cultural findings are further evidence that human pair-bonds may have evolved to support lactation. (shrink)

The risk of stroke for a child with SCD is many times greater than that of a healthy child without SCD or heart disease. There is a technique that allows the identification of the children with SCD who have high risk even within this relatively high-risk group. And there is a highly effective preventive treatment. While this would on the surface appear to be a straightforward medical decision, it is not. One must weigh the benefits of preventing permanent brain damage (...) against the risks of infection from transfused blood, iron overload, which is the result of the frequent transfusions, and rare transfusion reactions. (shrink)

Sickle cell anemia is a disease characterized by abnormal hemoglobin structure. There is a mutation in the beta-globin gene that changes the sixth amino acid from glutamic acid to valine causing the mutated hemoglobin to polymerize reversibly when deoxygenated to form a gelatinous network of fibrous polymers that stiffen and distort the red blood cell membrane. This leads to episodes of microvascular vasoocclusion and premature RBC destruction leading to hemolytic anemia. For reasons that are unclear, some children develop a large (...) artery vasculopathy involving the intracranial arteries supplying the brain.The risk of stroke for a child with SCD is many times greater than that of a healthy child without SCD or heart disease. There is a technique that allows the identification of the children with SCD who have high risk even within this relatively high-risk group. And there is a highly effective preventive treatment. (shrink)

Extrinsic mortality is a key influence on organisms’ life history strategies, especially on age at maturity. This historical longitudinal study of 125 women in rural Domenica examines effects of extrinsic mortality on human age at maturity and pace of reproduction. Extrinsic mortality is indicated by local population infant mortality rates during infancy and at maturity between the years 1925 and 2000. Extrinsic mortality shows effects on age at first birth and pace of reproduction among these women. Parish death records show (...) huge historical variation in age-specific mortality rates. The infant mortality rate (IMR) in the early 1920s was low, increased dramatically beginning in 1929, and reached a maximum in the 1950s, at which point IMR declined steadily to its present low rate. The mortality rate early in life showed a quadratic association with age at first birth. Women who experienced conditions of low IMR early in life reproduced relatively late in life. Those born into moderately high levels of infant mortality tended to reproduce earlier than those born at low levels. At very high infant mortality levels early in life, women went on to delay reproduction until relatively late, possibly as a result of somatic depletion and energetic stress associated with the conditions that lead to high IMR. Population mortality rates at age of maturity also showed a quadratic association with age at first birth. The pace of reproduction, estimated as number of surviving offspring controlled for maternal age, showed a similar quadratic effect. There were complex interactions between population mortality rates in infancy and at maturity. When extrinsic mortality was high during infancy, extrinsic mortality later in life had little effect on timing of first birth. When extrinsic mortality was low to moderate in infancy, extrinsic mortality later in life had significant effects on adult reproduction. I speculate that these effects are mediated through development of personality facets associated with reproduction. (shrink)

How can we experience real emotions when viewing a movie or reading a novel or watching a play when we know the characters whose actions have this effect on us do not exist? This is a conundrum that has puzzled philosophers for a long time, and in this book Robert Yanal both canvasses previously proposed solutions to it and offers one of his own. First formulated by Samuel Johnson, the paradox received its most famous answer from Samuel Taylor Coleridge, (...) who advised his readers to engage in a "willing suspension of disbelief." More recently, philosophers have argued that we are irrational in emoting toward fiction, or that we do not emote toward fiction but rather toward factual counterparts, or that we do not have real but only quasi-emotion toward fiction, generated by our playing games of make-believe. All of these proposed solutions are critically reviewed. Finding these answers unsatisfactory, Yanal offers an alternative, providing a new version of what has been dubbed "thought theory." On this theory, mere thoughts not believed true are seen as the functional equivalent of belief at least insofar as stimulating emotion is concerned. The emoter's disbelief in the actuality of components of the thoughts must be rendered relatively inactive. Such emotion is real and typically has the character of being richly generated yet unconsummated. The book extends this theory also to resolving other paradoxes arising from emotional response to fiction: how we feel suspense over what comes next in a story even when we are re-reading it for a second or third time; and how we take pleasure in narratives, such as tragedy, that excite unpleasant emotions such as fear, pity, or horror. (shrink)

Examines the skeptical arguments in David Hume's major work and analyzes the place of skepticism in his philosophy.

Patterns of human kinship commonly involve preferential treatment of relatives based on lineal descent (lineages) rather than degree of genetic relatedness (kindreds), presenting a challenge for inclusive fitness theory. Here, we examine effects of lineage and kindred characteristics on reproductive success (RS) and number of grandchildren for 130 men and 124 women in a horticultural community on Dominica. Kindreds had little effect on fitness independently of lineage characteristics. Fitness increased with the number of lineal relatives residing in the community but (...) decreased beyond an apparently optimal lineage size, suggesting resource enhancement and competition among kin. Female-biased patrilineage sex ratio was positively associated with men’s fitness, while male-biased matrilineage sex ratio was positively associated with women’s fitness. Number of brothers in the community was negatively associated with men’s, but not women’s, fitness. Parents and number of sisters had no effect on either male or female reproduction; however, women with younger sisters had higher RS, suggesting benefits of kin support for childcare. In sum, imposed norms for lineage social organization may enhance lineal ancestors’ inclusive fitness at a cost to individual inclusive fitness. (shrink)

The existence of a self seems both mysterious and inevitable. On the one hand, philosophers from the Buddha to Sartre doubt its existence. As Hume writes, when we introspect we find thoughts, feelings, and conscious states, but nothing that has them. The subject of experience is elusive, but its existence seems certain. Descartes’ cogito is beyond doubt and the thought that “I am thinking” involves an undeniable form of self-awareness. Self-Awareness and the Elusive Subject develops and defends the claim that (...) we don’t find ourselves in introspection, and that consciousness is, in general, impersonal. It then develops an account of self-awareness that takes these phenomenological data seriously. Our grasp of ourselves is epistemically robust but introspectively slight: we know ourselves most fundamentally as the bearers of our conscious states. (shrink)

arratives, fictional and factual, commonly raise in their audience suspense. A narrative lays out over time a sequence of events; and because the events of the narrative are not completely told all at once, questions arise for the audience which will be answered only later in the narrative’s telling. Will the transfigured panther-woman pounce on her rival as she walks home alone at night, hearing strange noises around her? Will Sam and Annie ever make their date at the top of (...) the Empire State Building? And the most classic question of all, Who dunnit?, or as it appears in its post-modern form, Who will do it? ‘This is the story of a murder. It hasn’t happened yet. But it will,’ Martin Amis writes at the beginning of London Fields. ‘I know the murderer, I know the murderee,’ and we’re soon told that the murderee is to be Nicola Six.1 But who will kill her? And why? (shrink)

The essay "Physique de croyant" is an important statement of Pierre Duhem's position on the relation between his science and his religion. Duhem trod a difficult path, some might say an impossible one, in Republican France because he was both a physicist and a devout Catholic. In this essay, using "Physique de croyant" as a touchstone, I explore the way in which he tried to reconcile his conflicting allegiances. There are several strands in Duhem's strategy that need to be teased (...) out. First, Duhem sought to defend his science against the charge that it was materialist and atheist. He did this with his claim, usually called the autonomy thesis, that physics and metaphysics are fundamentally different enterprises—that physics, properly conducted, has no metaphysical implications and requires no metaphysical support. This did not deny metaphysics its rightful territory. Second, Duhem used his segregationist position to defend the Roman Catholic Church against the assaults of the positivist scientism then in favor with the Republicans. Third, he also sought to protect his science against fellow Catholics who wanted to use it for polemical purposes. I develop and evaluate these lines of defense. (shrink)

This work, written from a neo-Pyrrhonian perspective, is an examination of contemporary theories of knowledge and justification. It takes ideas primarily found in Sextus Empiricus's Outlines of Pyrrhonism, restates them in a modern idiom, and then asks whether any contemporary theory of knowledge meets the challenges they raise. The first part, entitled "Gettier and the Problem of Knowledge," attempts to rescue our ordinary concept of knowledge from those philosophers who have assigned burdens to it that it cannot bear. Properly understood, (...) Fogelin shows that the concept of knowledge is unproblematic. The second part of this study, called "Agrippa and the Problem of Justification," examines Agrippa's contribution to Pyrrhonism, a systematic reduction of its procedures which came to be known as the "Five Modes Leading to the Suspension of Belief." These modes present a completely general procedure for refuting any claim a dogmatist might make. Though largely unnoticed, there is, according to Fogelin, an uncanny resemblance between problems posed by Agrippa's "Five Modes" and those that contemporary epistemologists address under the heading of a theory of justification. Fogelin examines the strongest contemporary theories of justification--in both foundationalist and anti-foundationalist forms. The conclusion is that recent philosophical writings on justification have made no significant progress in responding to the Pyrrhonian problems these writings have addressed. (shrink)

This first edition of this book was a broad study, drawing on a wide range of published research and historical evidence, of the enormous stock market boom that started around 1982 and picked up incredible speed after 1995. Although it took as its specific starting point this ongoing boom, it placed it in the context of stock market booms generally, and it also made concrete suggestions regarding policy changes that should be initiated in response to this and other such booms. (...) The book argued that the boom represents a speculative bubble, not grounded in sensible economic fundamentals. Part one of the book considered structural factors behind the boom. A list of twelve precipitating factors that appear to be its ultimate causes was given. Amplification mechanisms, naturally-occurring Ponzi processes, that enlarge the effects of these precipitating factors, were described. Part Two discussed cultural factors, the effects of the news media, and of "new era" economic thinking. Part Three discussed psychological factors, psychological anchors for the market and herd behavior. Part Four discussed attempts to rationalize exuberance: efficient markets theory and theories that investors are learning. Part Five presented policy options and actions that should be taken. The second edition, 2005, added an analysis of the real estate bubble as similar to the stock market bubble that preceded it, and warned that "Significant further rises in these markets could lead, eventually, to even more significant declines. The bad outcome could be that eventual declines would result in a substantial increase in the rate of personal bankruptcies, which could lead to a secondary string of bankruptcies of financial institutions as well. Another long-run consequence could be a decline in consumer and business confidence, and another, possibly worldwide, recession." Thus, the second edition of this book was among the first to warn of the global financial crisis that began with the subprime mortgage debacle in 2007. (shrink)

Plato and the trial of Socrates -- What is philosophy? -- Euthyphro : defining philosophical terms -- The apology, Phaedo, and Crito : the trial, immortality, and death of Socrates -- Philosophy of religion -- Can we prove that God exists? -- St. Anselm : the ontological argument -- St. Thomas Aquinas : the cosmological argument -- William Paley : the teleological argument -- Blaisepascal : it is better to believe in God's existence than to deny it -- William James (...) : free choice is the basis of belief -- Does the idea of a good God exclude evil? -- Gottfried Wilhelm Leibniz : God can allow some evil -- David Hume : a good God would exclude evil -- Ethics -- Are ethics relative? -- Ruth Benedict : ethics are relative -- W.T. Stace : ethics are not relative -- Are humans always selfish? -- Humans are always selfish : Glaucon's challenge to Socrates -- James Rachels : humans are not always selfish -- Which is basic in ethics : happiness or obligation? -- Aristotle : happiness is living virtuously -- Jeremy Bentham : happiness is seeking the greatest pleasure for the greatest number of people -- Immanuel Kant : duty is prior to happiness -- Friedrich Nietzsche : happiness is having power -- Jean-Paul Sartre : existentialist ethics -- Rosemarie Tong : feminist ethics are different -- Contemporary moral problems : abortion, homosexuality, animal rights -- Jane English : are most abortions moral? -- Peter Singer : do animals have rights? -- Knowledge -- What is knowledge? -- Plato : knowledge is warranted, true belief -- What method is best for acquiring knowledge? -- Charles Sanders Peirce : four approaches to philosophy -- How do we acquire knowledge? -- René Descartes : knowledge is not ultimately sense knowledge -- John Locke : knowledge is ultimately sensed -- Immanuel Kant : knowledge is both rational and empirical -- How is truth established? -- Bertrand Russell : truth is established by correspondence -- Francis H. Bradley : truth is established by coherence -- William James : truth is established on pragmatic grounds -- Can we know the nature of causal relations? -- David Hume : cause means regular association -- David Hume : there are no possible grounds for induction -- Metaphysics -- Why is there something rather than nothing? -- Parmenides : being is uncaused -- Lao-Tzu : non-being is the source of being -- Is reality general or particular? -- Plato : universals are real -- David Hume : particulars are real -- Of what does reality consist? -- René Descartes : reality consists of mind and matter -- Paul Churchland : reality consists of matter -- George Berkeley : reality consists of ideas -- John Dewey : reality consists of mental and physical qualities -- Are humans free? -- Holbach : humans are determined -- Robert Kane : humans are free -- Social and political philosophy -- What is liberty? -- Fyodor Dostoevski : liberty and authority -- John Stuart Mill : liberty is independence from the majority's tyranny -- Martin Luther King, Jr. : liberty and racial prejudice -- Which government is best? -- Thomas Hobbes : monarchy is best -- John Locke : democracy is best -- Karl Marx : communism and nonalienated labor is best -- Alexis de Tocqueville : democracy can have serious problems -- Karl Popper : utopias lead to violence -- Aesthetics -- What constitutes the experience of beauty? -- Plotinus : beauty, sensuous, and ideal -- What is the function of art? -- Aristotle : the nature of tragedy -- Henri Bergson : the nature of comedy -- Philosophy and the good life -- Classic views of the good life -- Epicurus : Epicurus and the pleasant life -- Epictetus : Epictetus and the life of self-control -- What gives life meaning? -- Leo Tolstoy : faith provides life's meaning -- Albert Camus : each person determines his or her life's meaning -- What is the value of philosophy? -- Bertrand Russell : the value of philosophy. (shrink)

Fr. Ernan McMullin wrote at least five essays in which anthropic reasoning in cosmology was a prominent topic of discussion and evaluation. Unlike thewritings of many passionate advocates and hostile critics of the so-called “anthropic principle” (AP), they are all nuanced essays—very much in keeping with Fr. Ernan’s usual approach to difficult and controversial subjects. Supporters of that approach will praise what he has to say as properly cautious and circumspect; others will likely find him often indecisive. In this essay, (...) I will indicate why, while I largely agree with the first group of readers, I am nevertheless sympathetic to the concerns of the latter group. (shrink)

This essay focuses on the place of the second law of thermodynamics in Wilhelm Ostwald's physical chemistry. After a brief introduction to his energetic theory, which was supposed to be a generalization of thermodynamics, I contrast Ostwald's understanding of the second law, which ignored entropy and irreversibility, with Max Planck's, which emphasized both. I then consider how Ostwald sought to develop physical chemistry without any concern for irreversibility and little concern for entropy, and I argue that he was mistaken.