Les réformes économiques néolibérales, suite à la crise financière de 1991, ont provoqué des mutations dans l’économie indienne, son développement industriel et agricole. Celles-ci ont touché l’ensemble de la population mais particulièrement, les groupes sociaux classés comme les plus vulnérables, telles que les communautés autochtones adivasi. Du point de vue des politiques publiques, ce qui caractérise les Adivasis, c’est leur désavantage économique et social. Ils font donc partie d’une catégorie sociale ciblée par différents programmes nationaux de développement et de (...) réduction de la pauvreté, notamment par l’intermédiaire du Dongria Kondh Development Agency (DKDA pour son acronyme anglais), département gouvernemental de médiation entre le gouvernement central indien et le groupe autochtone Dongria Kondh. C’est sur ce groupe que porte notre enquête anthropologique. Le présent article, dont les résultats s’appuient sur neuf mois de travail sur le terrain entre 2011 et 2015, vise à mettre en évidence la manière dont les politiques publiques nationales visant les communautés de dongria ont des impacts environnementaux et sociaux significatifs. (shrink)

This book is a comprehensive and unique text and reference in medical ethics. By far the most inclusive set of primary documents and articles in the field ever published, it contains over 100 selections. Virtually all pieces appear in their entirety, and a significant number would be difficult to obtain elsewhere. The volume draws upon the literature of history, medicine, philosophical and religious ethics, economics, and sociology. A wide range of topics and issues are covered, such as law and medicine, (...) truth-telling by the physician, research, population policy, genetics, abortion, dying, and individual rights in medical care. The selections span the centuries, beginning with material from the works of Hippocrates, continuing through Thomas Percival, John Stuart Mill, and Claude Bernard, down to modern commentators like Henry K. Beecher, Walsh McDermott, David L. Bazelon, Paul Freund, H. L. A. Hart, John Rawls, Paul Ramsey, Richard McCormick, Rashi Fein, and Bernard Barber. The text has eight major divisions, beginning with sections on the ethical dimensions of the physician-patient relationship in history; the moral bases of medical ethics; and regulation, compulsion, and protection of the consumer in clinical medicine and public health. Each of these sections includes key essays that appear for the first time. All of the book's major divisions contain primary documents: codes such as the Hippocratic Oath, Medieval Law for the Regulation of Medicine, and the first as well as the most recent code of the American Medical Association; court decisions, including those on Karen Quinlan and on abortion in the United States and West Germany; government documents such as the statement of the National Commission on the Protection of Human Subjects, the Tuskegee Syphilis Report, the British Parliamentary debate on euthanasia, and the Council of Europe on rights of the sick and dying; and various published guidelines such as the Harvard Medical School brain death criteria, the American Hospital Association on patient's rights, and Pope Pius XII on the prolongation of life. Cases that illustrate moral dilemmas are provided for discussion purposes. Each section is preceded by a succinct editor's introduction. The documents and essays are of practical value for practitioners and students in medicine, law, ethics, and counselling, and for individual patients and groups concerned with medical care. Through encompassing divergent viewpoints, the essays and primary documents were selected to encourage humane practices and deepen understanding of the multiple traditions that shaped and do shape the development of medicine. (shrink)

Résumé 1492. Les terres d’Amérique interpellent les européens. Certains y voient l’opportunité d’une utopie, d’autres l’utopie déjà à l’œuvre, à l’état naturel. Instantanément, deux processus de domination se mettent à l’œuvre : l’un soutenu par la force des armes, et l’autre par la puissance des idées et des croyances. Si les défenseurs de la pensée utopique furent capables de réaliser une œuvre durable, c’est parce qu’ils on su assortir leurs idées aux principes qui régissaient la vie sociale des populations (...) autochtones : une bonne part de ce qui subsiste de l’époque de Don Vasco de Quiroga l’avait donc précédée. Les cultures ne pourront dépasser les nationalismes et s’élever au niveau des inquiétudes communes à toute l’humanité que lors qu’elles auront su affirmer le caractère qui leur est propre face aux courants « mondialisants ». (shrink)

Les premières conférences John Robert Seeley, données par James Tully en 1994, traitaient des six types de demandes de reconnaissance culturelle qui sont au coeur des conflits les plus insolubles de notre époque : les associations supranationales, le nationalisme et le fédéralisme, les minorités linguistiques et ethniques, le féminisme, le multiculturalisme et l'autonomie gouvernementale des Autochtones. Ni les écoles actuelles du constitutionnalisme occidental moderne ni le constitutionnalisme post-moderne n'offrent d'outil équitable pour juger ces demandes diverses de reconnaissance parce qu'elles (...) reposent sur des suppositions indéfendables, héritées de l'époque de l'impérialisme européen. Toutefois, en effectuant une étude critique et historique de quatre cents ans de constitutionnalisme européen et non européen, et en prêtant une attention particulière aux populations autochtones d'Amérique, James Tully élabore une philosophie et une pratique post-impériales du constitutionnalisme. Elles consistent à concilier des demandes de reconnaissance à travers le temps grâce à des dialogues constitutionnels qui permettent à des citoyens de se mettre d'accord sur des formes adéquates d'accommodements de leurs différences culturelles, guidées par des conventions constitutionnelles communes. Cette forme de constitutionnalisme a la capacité de résoudre des conflits de notre époque et d'apporter la paix au vingt et unième siècle. (shrink)

La question des savoirs locaux suscite de nombreux débats sur la valeur et la considération que les uns et les autres leur accordent. Au-delà des aspects les plus vulgarisés que sont l’environnement et à la pharmacopée, cet article met en évidence une conception plus holiste des savoirs locaux et montre que leur valorisation est un enjeu de justice cognitive. À cette fin, l’auteur propose une stratégie numérique en quatre points adaptée au contexte camerounais : l’acquisition de compétences numériques par les (...) citoyens pour en faire des enregistreurs de savoirs locaux, les logiciels libres pour les stocker, le libre accès pour les diffuser et les politiques gouvernementales. (shrink)

What are the reasons for the autochtonous claims ? Being autochtonous is not so much based on belonging to a particular location as on providing an experimentation in other forms of agency. These forms come from heterogeneous positions of gaps and separations, situated in the cosmological exteriority of the Autochtonous People, who thus resist the hegemonic administration of populations.

Cet article est un premier essai d’étude historique sur les relations de genre dans les sociétés indigènes du Chaco, en Amérique du Sud. Le traitement de cette question nécessitant de travailler à partir de contextes sociaux, temporels et spatiaux concrets, nous avons situé l’analyse dans un secteur de la « frontière » chaquéenne placé sous la juridiction argentine, à des moments immédiatement antérieurs et postérieurs à la campagne militaire engagée pour soumettre les populations indigènes entre 1884 et 1911. Nous (...) travaillons ainsi depuis un front de colonisation interne pour repérer les changements que cette situation a provoqués sur les relations, les rôles sociaux et les identités des hommes et des femmes autochtones. L’analyse repose sur des sources issues de deux moments différents du processus de colonisation : le moment initial, à partir des missions franciscaines établies sur les bords du fleuve Bermejo pour évangéliser les Matacos ; puis l’apogée du processus, lorsque les Matacos furent incorporés comme brassiers salariés dans les raffineries sucrières. (shrink)

Le plan canonique rigoureusement normé de la domus étrusco-romaine, attesté dans la plus grande partie de l’Italie, pour l’essentiel, du vie au ier siècle av. J.‑C., a connu un succès très limité en dehors de la péninsule, où de fortes traditions autochtones, grecques ou puniques, semblent en avoir entravé le développement. Le cas de Délos présente un intérêt particulier à cet égard, compte tenu de l’importance de la composante italique de sa population. L’étude des maisons d’habitation du site, ici (...) envisagée en fonction d’une approche strictement planimétrique, montre cependant, en dépit de quelques convergences, que le plan canonique n’y a jamais été véritablement adopté par les élites locales ; les édifices qui s’en rapprochent le plus sont actuellement interprétés comme des bâtiments commerciaux. En revanche, la « Maison de Fourni » présente une très grande similitude avec les villae construites à la même époque en Italie, en particulier la Villa de Diomède à Pompéi. (shrink)

Cet article est un premier essai d’étude historique sur les relations de genre dans les sociétés indigènes du Chaco, en Amérique du Sud. Le traitement de cette question nécessitant de travailler à partir de contextes sociaux, temporels et spatiaux concrets, nous avons situé l’analyse dans un secteur de la « frontière » chaquéenne placé sous la juridiction argentine, à des moments immédiatement antérieurs et postérieurs à la campagne militaire engagée pour soumettre les populations indigènes entre 1884 et 1911. Nous (...) travaillons ainsi depuis un front de colonisation interne pour repérer les changements que cette situation a provoqués sur les relations, les rôles sociaux et les identités des hommes et des femmes autochtones. L’analyse repose sur des sources issues de deux moments différents du processus de colonisation : le moment initial, à partir des missions franciscaines établies sur les bords du fleuve Bermejo pour évangéliser les Matacos ; puis l’apogée du processus, lorsque les Matacos furent incorporés comme brassiers salariés dans les raffineries sucrières. (shrink)

Résumé Face à la mésentente disqualifiante autour de l’autochtonie des peuples, il faut reconsidérer fondamentalement les raisons de la revendication autochtone. En effet, être autochtone, ce n’est pas tant appartenir à un lieu qu’offrir la pensée d’une expérimentation de manières d’agir autrement dans le monde en partant des positions hétéroclites de l’écart et de la séparation. Ces positions, initialement comprises dans l’extériorité cosmologique des Peuples Autochtones, leur permettent ainsi de résister, en se revendiquant d’eux-mêmes, aux hégémonies des modes d’administration (...) des populations. (shrink)

Comment se concilient gouvernance autochtone et pluralisme identitaire dans le cas particulier du Nunavut ? Ces deux termes ont été forgés dans le cadre théorique du constitutionnalisme libéral, qui rend la conciliation soit impossible, soit contradictoire ; une exigence éthique conduit à repenser les termes de la question. L’histoire particulière du Nunavut, ainsi que les stratégies contentieuses identitaires, m’ont permis de le qualifier de modèle de gouvernance autochtone moderne. S’appuyant sur une forme de pluralisme juridique, rapidement le pluralisme dialogique est (...) devenu la condition à cette gouvernance hybride au Nunavut, dont la finalité évidente est la garantie d’un pluralisme identitaire renouvelé. (shrink)

Population axiology concerns how to evaluate populations in terms of their moral goodness, that is, how to order populations by the relations “is better than” and “is as good as”. The task has been to find an adequate theory about the moral value of states of affairs where the number of people, the quality of their lives, and their identities may vary. So far, this field has largely ignored issues about uncertainty and the conditions that have been discussed (...) mostly pertain to the ranking of risk-free outcomes. Most public policy choices, however, are decisions under uncertainty, including policy choices that affect the size of a population. Here, we shall address the question of how to rank population prospects—that is, alternatives that contain uncertainty as to which population they will bring about—by the relations “is better than” and “is as good as”. We start by illustrating how well-known population axiologies can be extended to population prospect axiologies. And we show that new problems arise when extending population axiologies to prospects. In particular, traditional population axiologies lead to prospect-versions of the problems that they praised for avoiding in the risk-free settings. Finally, we identify an intuitive adequacy condition that, we contend, should be satisfied by any population prospect axiology, and show how given this condition, the impossibility theorems in population axiology can be extended to (non-trivial) impossibility theorems for population prospect axiology. (shrink)

Human population genetic research (HPGR) seeks to identify the diversity and variation of the human genome and how human group and individual genetic diversity has developed. This book asks whether developing countries are well prepared for the ethical and legal conduct of human population genetic research, with specific regard to vulnerable target group protection. The book highlights particular issues raised by genetic research on populations as a whole, such as the capacity for current frameworks of Western developed countries to (...) provide adequate protections for target groups in human population genetic research, and explores potential groups of people that may suffer harm in this kind of research. Using The People's Republic of China as a key example, Yue Wang argues that since the target groups of HPGR are almost always vulnerable groups from isolated and rural areas of developing countries, the ethical and legal frameworks for human subject protection need to be reconsidered in order to eliminate, or at least reduce, the vulnerability of those groups. While most research in this field focuses on the impact on individuals, this book breaks new ground in exploring how the interests of target groups are also seriously implicated in genetic work. The book argues that current regulations are far from sufficient to prevent harm to vulnerable groups and puts forward an alternative model for group protection in the context of human population genetic research in developing countries. The book will be of great interest to students and academics of medical law, ethics, and the implications of genetic research. (shrink)

Le mégaprojet de centrale au charbon Thar (Thar Coal Mega Power Project) est l’un des plus ambitieux du Pakistan. Il affectera directement les communautés du désert de Thar sur une superficie d’environ neuf mille kilomètres carrés. Plus de deux cent cinquante villages seront évacués pour assurer son succès économique. Le projet a d’ores et déjà provoqué des migrations, des spéculations sur le sol, l’usurpation de pâturages communs et le rejet des communautés. Les conflits dans la région revêtent deux faces. D’abord, (...) on constate des conflits entre les communautés autochtones, l’État et les fonctionnaires de la Sindh Engro Coal Mining Company (SECMC). Ensuite, les problèmes intracommunautaires se sont transformés en conflits religieux entre musulmans et hindous, bien que les causes sous-jacentes soient environnementales. Cet article fournit une description critique des conflits, de l’usurpation de la terre, des processus de spéculation et d’accumulation dans la zone du projet. (shrink)

This book presents an exploration of the idea of the common or social good, extended so that alternatives with different populations can be ranked. The approach is, in the main, welfarist, basing rankings on the well-being, broadly conceived, of those who are alive. The axiomatic method is employed, and topics investigated include: the measurement of individual well-being, social attitudes toward inequality of well-being, the main classes of population principles, principles that provide incomplete rankings, principles that rank uncertain alternatives, best (...) choices from feasible sets, and applications. The chapters are divided, with mathematical arguments confined to the second part. The first part is intended to make the arguments accessible to a more general readership. Although the book can be read as a defense of the critical-level generalized-utilitarian class of principles, comprehensive examinations of other classes are included. (shrink)

The book presents a new way of understanding Darwinism and evolution by natural selection, combining work in biology, philosophy, and other fields.

In this paper, I plan to show that the use of a specific population concept—Millstein’s Causal Interactionist Population Concept (CIPC)—has interesting and counter-intuitive ramifications for discussions of the reality of biological race in human beings. These peculiar ramifications apply to human beings writ large and to individuals. While this in and of itself may not be problematic, I plan to show that the ramifications that follow from applying Millstein’s CIPC to human beings complicates specific biological racial realist accounts—naïve or otherwise. (...) I conclude with the notion that even if biological races do exist—by fulfilling all of the criteria needed for Millstein’s population concept (which, given particular worries raised by Gannett (Synthese 177:363–385, 2010), and Winther and Kaplan (Theoria 60:54–80, 2013) may not)—the lower-bound limit for the scope of biological racial realism is at the level of populations, and as such they cannot say anything about whether or not individual organisms themselves have races. (shrink)

Critical-Range Utilitarianism is a variant of Total Utilitarianism which can avoid both the Repugnant Conclusion and the Sadistic Conclusion in population ethics. Yet Standard Critical-Range Utilitarianism entails the Weak Sadistic Conclusion, that is, it entails that each population consisting of lives at a bad well-being level is not worse than some population consisting of lives at a good well-being level. In this paper, I defend a version of Critical-Range Utilitarianism which does not entail the Weak Sadistic Conclusion. This is made (...) possible by a fourth category of absolute value in addition to goodness, badness, and neutrality. (shrink)

Consider Phoebe and Daphne. Phoebe has credences in 1 million propositions. Daphne, on the other hand, has credences in all of these propositions, but she's also got credences in 999 million other propositions. Phoebe's credences are all very accurate. Each of Daphne's credences, in contrast, are not very accurate at all; each is a little more accurate than it is inaccurate, but not by much. Whose doxastic state is better, Phoebe's or Daphne's? It is clear that this question is analogous (...) to a question that has exercised ethicists over the past thirty years. How do we weigh a population consisting of some number of exceptionally happy and satisfied individuals against another population consisting of a much greater number of people whose lives are only just worth living? This is the question that occasions population ethics. In this paper, I go in search of the correct population ethics for credal states. (shrink)

The causes of prehistoric inter-group violence have been a subject of long-standing debate in archaeology, an- thropology, and other disciplines. Although population pressure has been considered as a major factor, due to the lack of available prehistoric data, few studies have directly examined its effect so far. In the present study, we used data on skeletal remains from the middle Yayoi period of the Japanese archipelago, where archaeologists argued that an increase of inter-group violence in this period could be explained (...) by a population-pressure hy- pothesis. We quantitatively examine the effect of population pressure on the frequency of inter-group violence by compiling an exhaustive data set. We collected demographic information based on burial jars (kamekan) and the frequency of violence based on the ratio of injured individuals. The results are consistent with the hypothesis, i. e., high population density can promote inter-group violence. (shrink)

and was correct to conclude that the way a biological population is described should affect conclusions about whether natural selection occurs, but wrong to conclude that natural selection is therefore not a cause. After providing a new argument that ignored crucial biological details, I give a biological illustration that motivates a fairly extreme dependence on description. I argue that contrary to an implication of , biologists allow much flexibility in describing populations, as contemporary research on recent human evolution shows. (...) Properly understood, such description-dependence is consistent with descriptions capturing different causal relations involving the same population. I thus show that Walsh’s arguments fail for reasons that have not previously been understood; I argue that Walsh’s more recent “Sure Thing” argument fails for similar reasons. The resulting view provides a new perspective on causation in evolutionary processes. (shrink)

Population axiology is the study of the conditions under which one state of affairs is better than another, when the states of affairs in ques- tion may differ over the numbers and the identities of the persons who ever live. Extant theories include totalism, averagism, variable value theories, critical level theories, and “person-affecting” theories. Each of these the- ories is open to objections that are at least prima facie serious. A series of impossibility theorems shows that this is no coincidence: (...) it can be proved, for various sets of prima facie intuitively compelling desiderata, that no axiology can simultaneously satisfy all the desiderata on the list. One’s choice of population axiology appears to be a choice of which intuition one is least unwilling to give up. (shrink)

One finds intertwined with ideas at the core of evolutionary theory claims about frequencies in counterfactual and infinitely large populations of organisms, as well as in sets of populations of organisms. One also finds claims about frequencies in counterfactual and infinitely large populations—of events—at the core of an answer to a question concerning the foundations of evolutionary theory. The question is this: To what do the numerical probabilities found throughout evolutionary theory correspond? The answer in question says (...) that evolutionary probabilities are “hypothetical frequencies” (including what are sometimes called “long-run frequencies” and “long-run propensities”). In this paper, I review two arguments against hypothetical frequencies. The arguments have implications for the interpretation of evolutionary probabilities, but more importantly, they seem to raise problems for biologists’ claims about frequencies in counterfactual or infinite populations of organisms and sets of populations of organisms. I argue that when properly understood, claims about frequencies in large and infinite populations of organisms and sets of populations are not threatened by the arguments. Seeing why gives us a clearer understanding of the nature of counterfactual and infinite population claims and probability in evolutionary theory. (shrink)

I defend a radical interpretation of biological populations—what I call population pluralism—which holds that there are many ways that a particular grouping of individuals can be related such that the grouping satisfies the conditions necessary for those individuals to evolve together. More constraining accounts of biological populations face empirical counter-examples and conceptual difficulties. One of the most intuitive and frequently employed conditions, causal connectivity—itself beset with numerous difficulties—is best construed by considering the relevant causal relations as ‘thick’ causal (...) concepts. I argue that the fine-grained causal relations that could constitute membership in a biological population are huge in number and many are manifested by degree, and thus we can construe population membership as being defined by massively multidimensional constructs, the differences between which are largely arbitrary. I end by showing that positions in two recent debates in theoretical biology depend on a view of biological populations at odds with the pluralism defended here. (shrink)

Two related asymmetries have been discussed in relation to the ethics of creating new lives: First, we seem to have strong moral reason to avoid creating lives that are not worth living, but no moral reason to create lives that are worth living. Second, we seem to have strong moral reason to improve the wellbeing of existing lives, but, again, no moral reason to create lives that are worth living. Both asymmetries have proven very difficult to account for in any (...) coherent moral framework. I propose an impersonal population axiology to underpin the asymmetries, which sidesteps the problematic issue of whether or not people can be harmed or benefited by creation or non-creation. This axiology yields perfect asymmetry from a deliberative perspective, in terms of expected value. The axiology also yields substantial asymmetry for large and realistic populations in terms of their actual value, beyond deliberative relevance. (shrink)

Concerns about population ageing apply to both developed and many developing countries and it has turned into a global issue. In the forthcoming decades the population ageing is likely to become one of the most important processes determining the future society characteristics and the direction of technological development. The present paper analyzes some aspects of the population ageing and its important consequences for particular societies and the whole world. Basing on this analysis, we can draw a conclusion that the future (...) technological breakthrough is likely to take place in the 2030s (which we define as the final phase of the Cybernetic Revolution). In the 2020s – 2030s we will expect the upswing of the forthcoming sixth Kondratieff wave, which will introduce the sixth technological paradigm (system). All those revolutionary technological changes will be connected, first of all, with breakthroughs in medicine and related technologies. We also present our ideas about the financial instruments that can help to solve the problem of pension provision for an in-creasing elderly population in the developed countries. We think that a more purposeful use of pension funds' assets together with an allocation (with necessary guarantees) of the latter into education and upgrading skills of young people in developing countries, perhaps, can partially solve the indicated problem in the developed states. (shrink)

Contrary to political and philosophical consensus, we argue that the threats posed by climate change justify population engineering, the intentional manipulation of the size and structure of human populations. Specifically, we defend three types of policies aimed at reducing fertility rates: choice enhancement, preference adjustment, and incentivization. While few object to the first type of policy, the latter two are generally rejected because of their potential for coercion or morally objectionable manipulation. We argue that forms of each policy type (...) are pragmatically and morally justified tools for preventing the harms of global climate change. (shrink)

In the Preface of Animal Species and Evolution (1963), I wrote that it was "an attempt to summarize and review critically what we know about the biology and genetics of animal species and their role in evolution." The result was a volume of XIV ...

Ernst Mayr has argued that Darwinian theory discredited essentialist modes of thought and replaced them with what he has called "population thinking". In this paper, I characterize essentialism as embodying a certain conception of how variation in nature is to be explained, and show how this conception was undermined by evolutionary theory. The Darwinian doctrine of evolutionary gradualism makes it impossible to say exactly where one species ends and another begins; such line-drawing problems are often taken to be the decisive (...) reason for thinking that essentialism is untenable. However, according to the view of essentialism I suggest, this familiar objection is not fatal to essentialism. It is rather the essentialist's use of what I call the natural state model for explaining variation which clashes with evolutionary theory. This model implemented the essentialist's requirement that properties of populations be defined in terms of properties of member organisms. Requiring such constituent definitions is reductionistic in spirit; additionally, evolutionary theory shows that such definitions are not available, and, moreover, that they are not needed to legitimize population-level concepts. Population thinking involves the thesis that population concepts may be legitimized by showing their connections with each other, even when they are not reducible to concepts applying at lower levels of organization. In the paper, I develop these points by describing Aristotle's ideas on the origins of biological variation; they are a classic formulation of the natural state model. I also describe how the development of statistical ideas in the 19th century involved an abandoning of the natural state model. (shrink)

I defend a radical interpretation of biological populations—what I call population pluralism—which holds that there are many ways that a particular grouping of individuals can be related such that the grouping satisfies the conditions necessary for those individuals to evolve together. More constraining accounts of biological populations face empirical counter-examples and conceptual difficulties. One of the most intuitive and frequently employed conditions, causal connectivity—itself beset with numerous difficulties—is best construed by considering the relevant causal relations as ‘thick’ causal (...) concepts. I argue that the fine-grained causal relations that could constitute membership in a biological population are huge in number and many are manifested by degree, and thus we can construe population membership as being defined by massively multidimensional constructs, the differences between which are largely arbitrary. I end by showing that positions in two recent debates in theoretical biology depend on a view of biological populations at odds with the pluralism defended here. 1 Introduction2 Biological Population, Broad and Narrow3 Difficulties with Narrow Biological Population Conditions3.1 Against the genealogical condition3.2 Against the conspecificity condition3.3 Against the proximity condition3.4 Against the typology condition4 Causal Connectivity5 Massively Multidimensional Population Constructs6 Population Uniqueness and Natural Selection6.1 Statisticalism and its discontents6.2 Price at what price?7 Conclusion. (shrink)

Tissues contain complex populations of cells. Like countries, which are comprised of mixed populations of people, tissues are not homogeneous. Gene expression studies that analyze entire populations of cells from tissues as a mixture are blind to this diversity. Thus, critical information is lost when studying samples rich in specialized but diverse cells such as tumors, iPS colonies, or brain tissue. High throughput methods are needed to address, model and understand the constitutive and stochastic differences between individual (...) cells. Here, we describe microfluidics technologies that utilize a combination of molecular biology and miniaturized labs on chips to study gene expression at the single cell level. We discuss how the characterization of the transcriptome of each cell in a sample will open a new field in gene expression analysis, population transcriptomics, that will change the academic and biomedical analysis of complex samples by defining them as quantified populations of single cells. (shrink)

This paper advances a new criterion of a vulnerable population in research. According to this criterion, there are consent-based and fairness-based reasons for calling a group vulnerable. The criterion is then applied to the case of people with serious illnesses. It is argued that people with serious illnesses meet this criterion for reasons related to consent. Seriously ill people have a susceptibility to “enticing offers” that hold out the prospect of removing or alleviating illness, and this susceptibility reduces their ability (...) to safeguard their own interests. This explains the inclusion of people with serious illnesses in the Belmont Report’s list of populations needing special protections, and supports the claim that vulnerability is the rule, rather than the exception, in biomedical research. (shrink)

Two new modes of thinking have spread through systematics in the twentieth century. Both have deep historical roots, but they have been widely accepted only during this century. Population thinking overtook the field in the early part of the century, culminating in the full development of population systematics in the 1930s and 1940s, and the subsequent growth of the entire field of population biology. Population thinking rejects the idea that each species has a natural type (as the earlier essentialist view (...) had assumed), and instead sees every species as a varying population of interbreeding individuals. Tree thinking has spread through the field since the 1960s with the development of phylogenetic systematics. Tree thinking recognizes that species are not independent replicates within a class (as earlier group thinkers had tended to see them), but are instead interconnected parts of an evolutionary tree. It lays emphasis on the explanation of evolutionary events in the context of a tree, rather than on the states exhibited by collections of species, and it sees evolutionary history as a story of divergence rather than a story of development. Just as population thinking gave rise to the new field of population biology, so tree thinking is giving rise to the new field of phylogenetic biology. (shrink)

Ernst Mayr has criticised the methodology of population genetics for being essentialist: interested only in “types” as opposed to individuals. In fact, he goes so far as to claim that “he who does not understand the uniqueness of individuals is unable to understand the working of natural selection” (1982, 47). This is a strong claim indeed especially since many responsible for the development of population genetics (especially Fisher, Haldane, and Wright) were avid Darwinians. In order to unravel this apparent incompatibility (...) I want to examine the possible sources and implications of essentialism in this context and show why the kind of mathematical analysis found in Fisher's work is better seen as responsible for extending the theory of natural selection to a broader context rather than inhibiting its applicability. (shrink)

The concept of population thinking was introduced by Ernst Mayr as the right way of thinking about the biological domain, but it is difficult to find an interpretation of this notion that is both unproblematic and does the theoretical work it was intended to do. I argue that, properly conceived, Mayr’s population thinking is a version of trope nominalism: the view that biological property-types do not exist or at least they play no explanatory role. Further, although population thinking has been (...) traditionally used to argue against essentialism about biological kinds, recently it has been suggested that it may be consistent with at least some forms of essentialism—ones that construe essential properties as relational. I argue that if population thinking is a version of trope nominalism, then, as Mayr originally claimed, it rules out any version of essentialism about biological kinds. (shrink)

Nearly all large policy decisions influence not only the quality of life for existing individuals but also the number-and even identities-of yet-to-exist individuals. Accounting for these effects in a policy evaluation framework requires taking difficult stances on concepts such as the value of existence. These issues are at the heart of a literature that sits between welfare economics and philosophical population ethics. Despite the inherent challenges of these questions, this literature has produced theoretical insights and subsequent progress on variable-population welfare (...) criteria. A surprisingly bounded set of coherent alternatives exists for practitioners once a set of uncontroversial axioms is adopted from the better-studied welfare criteria for cases where populations are assumed to be fixed. Although consensus has not yet been reached among these remaining alternatives, their recommendations often agree. The space has been sufficiently restricted and well explored that applications of the theoretical insights are possible and underway in earnest. (shrink)

Population genetics attempts to measure the influence of the causes of evolution, viz., mutation, migration, natural selection, and random genetic drift, by understanding the way those causes change the genetics of populations. But how does it accomplish this goal? After a short introduction, we begin in section (2) with a brief historical outline of the origins of population genetics. In section (3), we sketch the model theoretic structure of population genetics, providing the flavor of the ways in which population (...) genetics theory might be understood as incorporating causes. In sections (4) and (5) we discuss two specific problems concerning the relationship between population genetics and evolutionary causes, viz., the problem of conceptually distinguishing natural selection from random genetic drift, and the problem of interpreting fitness. In section (6), we briefly discuss the methodology and key epistemological problems faced by population geneticists in uncovering the causes of evolution. Section (7) of the essay contains concluding remarks. (shrink)

In this paper, the author questions whether the research ethics guidelines and procedures are robust enough to protect groups when conducting genetics research with socially identifiable populations, particularly with Native American groups. The author argues for a change in the federal guidelines in substance and procedures of conducting genetic research with socially identifiable groups.

Jean-Olivier Roy | : L’étude des nations et du nationalisme autochtones contemporains présente des défis en raison des divergences, chez les penseurs et les acteurs politiques, quant à leur nature et leur interprétation. Nous constatons que le nationalisme autochtone, à la base principalement ethnique ou culturel, accorde de plus en plus d’importance aux revendications politiques, dépassant ainsi les simples protections culturelles. Cet article pose l’hypothèse que les nations et le nationalisme autochtones, malgré les références aux traditions et à (...) leur origine immémoriale, sont des construits en perpétuelle mutation, notamment sous l’influence des nationalismes environnants et de la modernité politique. Pour développer cette hypothèse, nous examinons les propos des acteurs et des penseurs au moyen des différentes théories de la nation. | : The study of indigenous nations and nationalism poses several challenges based on the disagreements that their interpretation poses for the theorists and political actors alike. We note that indigenous nationalism, based on ethnic or cultural grounds, attributes increasing importance to political demands, thereby leaving behind claims for cultural protections. This article argues that despite references to tradition and culture, indigenous nations and nationalisms are in constant flux, subject to the influences of nationalisms around them and the demands of political modernity. To support this claim, we examine the proposals by several theorists and political actors across theories of the nation. (shrink)

In his prophetic book Amythia, Loyal Rue calls for the construction of bold new myths. Responding to his call in light of scientific arguments for global population equilibrium, this article proposes a model that may function as a surrogate form of myth, one that can motivate our age and future ages. Fortunately, the model is not only powerful but achievable, because policy makers have finally begun to realize how thoroughly the human population impacts on other world dynamics. The problem is (...) reviewed, the relevance of scientific and theological studies bearing on it is shown, and the new model is described. Above all, an effort is made to show how global equilibrium can support Rue's twin requirements for the myth he commissions: namely, a foundation in plausible descriptions of reality, and a compelling normative status. (shrink)

Cet article propose une réflexion sur la manière d’appréhender, en milieu autochtone, la collecte et l’analyse des données, les deux dimensions de la recherche qui sont les plus vulnérables aux biais ethnocentriques. En optant pour une démarche qui part du point de vue des participants eux-mêmes, il est suggéré de porter un regard de l’intérieur et d’aller à la rencontre du savoir intime, culturellement et territorialement situé, afin d’éclairer les choix réflexifs et originaux que font les acteurs autochtones. Pour (...) cela, il est proposé d’opter pour l’approche biographique et d’adapter celle-ci en fonction des réalités et des demandes des partenaires de recherche autochtones. Cette adaptation doit s’effectuer à différentes étapes du processus, notamment à l’étape de l’analyse et de la valorisation des résultats. Il est notamment proposé que les récits biographiques ne devraient pas être considérés comme de simples données de terrain, mais plutôt comme un niveau d’analyse en soi et qu’à ce titre, ils devraient pouvoir avoir une existence propre, en dehors tout autant qu’au sein de la recherche. (shrink)

A systematic, rigorous, comprehensive, and unified overview of evolutionary game theory.

Contemporary biology has inherited two key assumptions from the Modern Synthesis about the nature of population lineages: sexual reproduction is the exemplar for how individuals in population lineages inherit traits from their parents, and random mating is the exemplar for reproductive interaction. While these assumptions have been extremely fruitful for a number of fields, such as population genetics and phylogenetics, they are increasingly unviable for studying the full diversity and evolution of life. I introduce the “mixture” account of population lineages (...) that escapes these assumptions by dissolving the Modern Synthesis’s sharp line separating reproduction and development and characterizing reproductive integration in population lineages by the ephemerality of isolated subgroups rather than random mating. The mixture account provides a single criterion for reproductive integration that accommodates both sexual and asexual reproduction, unifying their treatment under Kevin de Queiroz’s generalized lineage concept of species. The account also provides a new basis for empirically assessing the effect of random mating as an idealization on the empirical adequacy of population genetic models. (shrink)