Adaptive mutation is defined as a process that, during nonlethal selections, produces mutations that relieve the selective pressure whether or not other, nonselected mutations are also produced. Examples of adaptive mutation or related phenomena have been reported in bacteria and yeast but not yet outside of microorganisms. A decade of research on adaptive mutation has revealed mechanisms that may increase mutation rates under adverse conditions. This article focuses on mechanisms that produce adaptive mutations in one strain of Escherichia coli, FC40. (...) These mechanisms include recombination-induced DNA replication, the placement of genes on a conjugal plasmid, and a transient mutator state. The implications of these various phenomena for adaptive evolution in microorganisms are discussed. BioEssays 22:1067–1074, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

The neuromodulatory effects of brain stimulation therapies notably involving repetitive transcranial magnetic stimulation on nocturnal sleep, which is critically disturbed in major depression and other neuropsychiatric disorders, remain largely undetermined. We have previously reported in major depression patients that prefrontal rTMS sessions enhanced their slow wave activity power, but not their sigma power which is related to sleep spindle activity, for electrodes located nearby the stimulation site. In the present study, we focused on measuring the spindle density to investigate cumulative (...) effects of prefrontal rTMS sessions on the sleep spindle activity. Fourteen male inpatients diagnosed with medication-resistant unipolar or bipolar depression were recruited and subjected to 10 daily rTMS sessions targeting the left dorsolateral prefrontal cortex. All-night polysomnography data was acquired at four time points: Adaptation, Baseline, Post-1, and Post-2. Clinical and cognitive evaluations were longitudinally performed at Baseline, Post-1, and Post-2 time points to explore associations with the spindle density changes. The PSG data from 12 of 14 patients was analyzed to identify sleep spindles across the sleep stages II–IV at four electrode sites: F3, F4, P3, and P4. Statistical analysis by two-way ANOVA revealed that spindle density at F3 increased at Post-1 but decreased at Post-2 time points. Moreover, the local and transient increase of spindle density at F3 was associated with the previously reported SWA power increase at F3, possibly reflecting a shared mechanism of thalamocortical synchronization locally enhanced by diurnal prefrontal rTMS sessions. Clinical and cognitive correlations were not observed in this dataset. These findings suggest that diurnal rTMS sessions transiently modulate nocturnal sleep spindle activity at the stimulation site, although clinical and cognitive effects of the local changes warrant further investigation. (shrink)

Adaptive mutation is defined as a process that, during nonlethal selections, produces mutations that relieve the selective pressure whether or not other, nonselected mutations are also produced. Examples of adaptive mutation or related phenomena have been reported in bacteria and yeast but not yet outside of microorganisms. A decade of research on adaptive mutation has revealed mechanisms that may increase mutation rates under adverse conditions. This article focuses on mechanisms that produce adaptive mutations in one strain of Escherichia coli, FC40. (...) These mechanisms include recombination-induced DNA replication, the placement of genes on a conjugal plasmid, and a transient mutator state. The implications of these various phenomena for adaptive evolution in microorganisms are discussed. BioEssays 22:1067–1074, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Perfect adaptation in a dynamical system is the phenomenon that one or more variables have an initial transient response to a persistent change in an external stimulus but revert to their original value as the system converges to equilibrium. With the help of the causal ordering algorithm, one can construct graphical representations of dynamical systems that represent the causal relations between the variables and the conditional independences in the equilibrium distribution. We apply these tools to formulate sufficient graphical (...) conditions for identifying perfect adaptation from a set of first-order differential equations. Furthermore, we give sufficient conditions to test for the presence of perfect adaptation in experimental equilibrium data. We apply this method to a simple model for a protein signalling pathway and test its predictions in both simulations and using real-world protein expression data. We demonstrate that perfect adaptation can lead to misleading orientation of edges in the output of causal discovery algorithms. (shrink)

To give substance to the rhetoric of ‘learning health systems’, a variety of novel trial designs are being explored to more seamlessly integrate research with medical practice, reduce study duration and reduce the number of participants allocated to ineffective interventions. Many of these designs rely on response adaptive randomisation. However, critics charge that RAR is unethical on the grounds that it violates the principle of equipoise. In this paper, I reconstruct critiques of RAR as holding that it is inconsistent with (...) five important ethical principles. I then argue that these criticisms rest on a faulty view of equipoise encouraged by the idea that a RAR study models the beliefs of a single rational agent about the relative merits of the interventions being studied. I outline a view in which RAR models an idealised health system in which diverse communities of fully informed experts shrink or grow as their constituent members update their expert opinions in light of reliable medical evidence. I show how a proper understanding of clinical equipoise can reconcile this conception of RAR with these five ethical principles. This analysis removes an in-principle objection to RAR and sheds important light on the relationship between clinical equipoise and transient diversity in the scientific community. (shrink)

In concert with the selective pressures affecting protein folding and function in the extreme environments in which they can exist, proteins in Archaea have evolved to present permanent molecular adaptations at the amino acid sequence level. Such adaptations may not, however, suffice when Archaea encounter transient changes in their surroundings. Post‐translational modifications offer a rapid and reversible layer of adaptation for proteins to cope with such situations. Here, it is proposed that Archaea further augment their ability to survive (...) changing growth conditions by modifying the extent, position, and, where relevant, the composition of different post‐translational modifications, as a function of the environment. Support for this hypothesis comes from recent reports describing how patterns of protein glycosylation, methylation, and other post‐translational modifications of archaeal proteins are altered in response to environmental change. Indeed, adjusting post‐translational modifications as a means to cope with environmental variability may also hold true beyond the Archaea. (shrink)

The adaptation-by-binding account and the arousal-biased competition model suggest that emotional arousal increases binding effects for transient links between stimuli and responses. Two highly-powered, pre-registered experiments tested whether transient stimulus-response bindings are stronger for high versus low arousing stimuli. Emotional words were presented in a sequential prime-probe design in which stimulus relation, response relation, and stimulus arousal were orthogonally manipulated. In Experiment 1 (N = 101), words with high and low arousal levels were presented individually in prime (...) and probe displays. In Experiment 2 (N = 170), a high arousing affective word was presented simultaneously with a neutral word during the prime display; in the subsequent probe display, either the arousing or the neutral word repeated or a different high versus low arousal word was shown. Data from both experiments did not demonstrate a modulation of SRBR effects by stimulus arousal and SRBR effects were of equal magnitude for word stimuli of high and low arousal levels. These null results are not in line with binding accounts that hypothesise a modulatory influence of emotional arousal on perception-action binding. (shrink)

Schemas contribute to adaptation, filtering novelty though knowledge-expectancy structures, the residue of past contingencies and their consequences. Adaptation requires a balance between flexible, dynamic context-sensitivity and the cognitive efficiency that schemas afford in promoting persistent goal pursuit despite distraction. Affects can form and disrupt schemas. Transient affective experiences systematically alter selectivity of attentiveness to the directly experienced present environment, the internal environment, and to the stored experiences of memory. Enduring personal stylistic predispositions, like implicit motives and affective (...) schemas, influence how experience is perceived, responded to, and integrated; they shape memory and influence present experiential patterns, individually and intersubjectively. Such systematic influences are potential sources of error in the study of memory if not mapped; so far, individual personality differences have just been a source of complication in the literature on emotion-congruent perception and memory. I synthesize what findings there are about how personality differences, emotions, and affects contribute to the structuring and integration of perceptions and memories both directly and by way of hot, affectively-anchored schemas. Case studies from experimental and personality psychology highlight a conception of personality and affective experience relevant to memory research and cognitive science. (shrink)

Immunology — though deeply experimental in everyday practice — is also a theoretical discipline. Recent advances in the understanding of innate immunity, how it is triggered and how it shares features that have previously been uniquely ascribed to the adaptive immune system, can contribute to the refinement of the theoretical framework of immunology. In particular, natural killer cells and macrophages are activated by transient modifications, but adapt to long-lasting modifications that occur in the surrounding tissue environment. This process facilitates (...) the maintenance of self-tolerance while permitting efficient immune responses. In this Essay we extend this idea to other components of the immune system and we propose some general principles that lay the foundations for a unifying theory of immunity — the discontinuity theory. According to this theoretical framework, effector immune responses (namely, activated responses that lead to the potential elimination of the target antigen) are induced by an antigenic discontinuity; that is, by the sudden modification of molecular motifs with which immune cells interact. (shrink)

Working memory (WM) is a fundamental cognitive ability to support complex thought, but it is limited in capacity. WM training has shown the potential to make benefit for those in need. Many studies have shown the potential of transcranial direct current stimulation (tDCS) to transiently enhance WM performance by delivering low current to the brain cortex of interest via electrodes on the scalp. TDCS has also been revealed as a promising intervention to augment WM training in a few studies. However, (...) those few tDCS-paired WM training studies focused more on the effect of tDCS on WM enhancement and its transferability after training but paid less attention to the variation of cognitive performance during the training procedure. The current study attempted to explore the effect of tDCS on the variation of performance during WM training in healthy young adults. All the participant received WM training with the load-adaptive verbal N-back task for five days. During the training procedure, active/sham anodal high-definition tDCS (HD-tDCS) was used to stimulate the left dorsolateral prefrontal cortex (DLPFC). To examine the training effect, pre- and post-test were performed respectively one-day before and after the training sessions respectively. At the beginning of each training session, stable-load WM tasks were performed to examine the performance variation during training. Compared to the sham stimulation, higher learning rates of performance metrics during the training procedure were found when WM training was combined with active anodal HD-tDCS. The performance improvements (post-pre) of the active group were also found to be higher than those of sham group and were transferred to a similar untrained WM task. Further analysis revealed that the negative relation between the training improvements and baseline performance. These findings show the potential that tDCS may be leveraged as an intervention to facilitate WM training for those in need of higher WM ability. (shrink)

Most studies of motifs of biological regulatory networks focus on the analysis of asymptotical behaviours, but transient properties are rarely addressed. In the line of our previous study devoted to isolated circuits 19:172–178, 2003), we consider chorded circuits, that are motifs made of an elementary positive or negative circuit with a chord, possibly a self-loop. We provide detailed descriptions of the boolean dynamics of chorded circuits versus isolated circuits, under the synchronous and asynchronous updating schemes within the logical formalism. (...) To this end, we address the description of the trajectories in the dynamics of isolated circuits with coding techniques and adapt them for chorded circuits. The use of the logical modeling gives access to mathematical tools allowing complete analytical analysis of basic yet important motifs. In particular, we show that whatever the chosen updating rule, the dynamics depends on a small number of parameters. (shrink)

This paper is concerned with the modeling of neural systems regarded as information processing entities. I investigate the various dynamic regimes that are accessible in neural networks considered as nonlinear adaptive dynamic systems. The possibilities of obtaining steady, oscillatory or chaotic regimes are illustrated with different neural network models. Some aspects of the dependence of the dynamic regimes upon the synaptic couplings are examined. I emphasize the role that the various regimes may play to support information processing abilities. I present (...) an example where controlled transient evolutions in a neural network, are used to model the regulation of motor activities by the cerebellar cortex. (shrink)

The complex sensation of vision begins with the relatively simple photoisomerization of the visual pigment chromophore 11-cis-retinal to its all-trans configuration. This event initiates a series of biochemical reactions that are collectively referred to as phototransduction, which ultimately lead to a change in the electrochemical signaling of the photoreceptor cell. To operate in a wide range of light intensities, however, the phototransduction pathway must allow for adjustments to background light. These take place through physiological adaptation processes that rely primarily (...) on Ca2+ ions. While Ca2+ may modulate some activities directly, it is more often the case that Ca2+-binding proteins mediate between transient changes in the concentration of Ca2+ and the adaptation processes that are associated with phototransduction. Recently, combined genetic, physiological, and biochemical analyses have yielded new insights about the properties and functions of many phototransduction-specific components, including some novel Ca2+-binding proteins. Understanding these Ca2+-binding proteins will provide a more complete picture of visual transduction, including the mechanisms associated with adaptation, and of related degenerative diseases. BioEssays 22:337–350, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & the Environment 8.1 (2003) 143-150 [Access article in PDF] Species Nova [To See Anew]Art as Ecology David Haley Looking Back From space, looking back at earth, we may see three key issues: the accelerating increase of the human species, the accelerating decrease of other species, and the accelerating effects of climate change. We might ask, how are we to cope with these changes creatively?That our societies tend (...) to value economics over ecology, and monoculture and agro-industry over diversity and permaculture, is certainly worthy of ethical attention. Here I want to invoke a call for integrating art as a necessary contribution to ecological intervention. I consider how artists may engage uncertainty, and how art may be used to develop new ways of seeing and "drawing." This is art for evolutionary survival, not commodification. Art that practices care, shared responsibility, and diversity in the pursuit of eco-centric cultures. Although this paper mainly references visual art forms, this should not be taken to exclude others. Here I am primarily concerned with identifying some of the possible forms of ecological or eco-art. This is art practiced by artist and inventors in the manner of the archetype of Daedalus and worthy of the name implied by the root of the word art. Rt, an ancient term from the Rg Vedas, refers to the virtuous, continuing creation of the cosmos. [End Page 143] Seeing is Believing/ Uncertainty in View The suffix species nova is ascribed by scientists to a new bacterium species, prior to the confirmation of its existence in the appropriate academic journals. The word species means "to look" and "a class of things, living organisms capable of exchanging genes, classified as a taxonomic rank below a genus and denoted by a Latin binomial." It also refers to "the visible form of each of the elements of consecrated bread and wine in the Eucharist." Nova refers to the mistaken sighting of a new star, a flash of brightness that quickly dims. Something novel is a new kind of nature, something strange or previously unknown, and novelty refers to invention. Species nova: two words that evoke ideas about innovations of visual experience and belief.I use the phrase to denote the potential for understanding a new order and evolutionary change—"to see anew." I am also aware that species nova could mean a mistaken religious experience, or a class of living things that flashes brightly and quickly dims. Uncertainty is embedded in the richness of meanings.It is ten years since the Earth Summit in Rio popularized the notion of sustainable development and introduced Agenda 21 as a strategy to achieve it. Sadly, culture and art, two of the systems that define humanity, were not mentioned among the necessary tools for building a better future.But what is sustainable development? Is it about conservation, restoration, or regeneration? Will it stop global warming and feed the poor, or is it like candyfloss—a confection of transient comfort, with no real meaning? Has it become a corrupt cultural construct, an anthropocentric myth in the vain pursuit of hope?Recently the Intergovernmental Panel on Climate Change confirmed that "most of the warming observed over the past 50 years is attributable to human activities." However, the projections and models that have been developed for policy makers to envisage climate change scenarios demonstrate the limits of our ability to understand the situation, let alone adapt to it. A recent review in Nature, comparing two twenty-year forecasts ironically concluded: Uncertainties therefore remain that are beyond the statistical uncertainties described in the two papers. But both sets of authors point out that the upper bound on the potential warming for 2100 may well be [End Page 144] above the IPCC figure of 5.8K under 'heavy emissions' scenarios. So policy-makers should not discount the possibility of a very warm climate considering long-range policy options. (Funnel 2001, 5) A subsequent article in Nature's Climate Change Review reveals even more concern about communicating scientific uncertainty, because models that simulate long-term climate changes cannot be tested using real... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & the Environment 8.1 (2003) 143-150 [Access article in PDF] Species Nova [To See Anew]Art as Ecology David Haley Looking Back From space, looking back at earth, we may see three key issues: the accelerating increase of the human species, the accelerating decrease of other species, and the accelerating effects of climate change. We might ask, how are we to cope with these changes creatively?That our societies tend (...) to value economics over ecology, and monoculture and agro-industry over diversity and permaculture, is certainly worthy of ethical attention. Here I want to invoke a call for integrating art as a necessary contribution to ecological intervention. I consider how artists may engage uncertainty, and how art may be used to develop new ways of seeing and "drawing." This is art for evolutionary survival, not commodification. Art that practices care, shared responsibility, and diversity in the pursuit of eco-centric cultures. Although this paper mainly references visual art forms, this should not be taken to exclude others. Here I am primarily concerned with identifying some of the possible forms of ecological or eco-art. This is art practiced by artist and inventors in the manner of the archetype of Daedalus and worthy of the name implied by the root of the word art. Rt, an ancient term from the Rg Vedas, refers to the virtuous, continuing creation of the cosmos. [End Page 143] Seeing is Believing/ Uncertainty in View The suffix species nova is ascribed by scientists to a new bacterium species, prior to the confirmation of its existence in the appropriate academic journals. The word species means "to look" and "a class of things, living organisms capable of exchanging genes, classified as a taxonomic rank below a genus and denoted by a Latin binomial." It also refers to "the visible form of each of the elements of consecrated bread and wine in the Eucharist." Nova refers to the mistaken sighting of a new star, a flash of brightness that quickly dims. Something novel is a new kind of nature, something strange or previously unknown, and novelty refers to invention. Species nova: two words that evoke ideas about innovations of visual experience and belief.I use the phrase to denote the potential for understanding a new order and evolutionary change—"to see anew." I am also aware that species nova could mean a mistaken religious experience, or a class of living things that flashes brightly and quickly dims. Uncertainty is embedded in the richness of meanings.It is ten years since the Earth Summit in Rio popularized the notion of sustainable development and introduced Agenda 21 as a strategy to achieve it. Sadly, culture and art, two of the systems that define humanity, were not mentioned among the necessary tools for building a better future.But what is sustainable development? Is it about conservation, restoration, or regeneration? Will it stop global warming and feed the poor, or is it like candyfloss—a confection of transient comfort, with no real meaning? Has it become a corrupt cultural construct, an anthropocentric myth in the vain pursuit of hope?Recently the Intergovernmental Panel on Climate Change confirmed that "most of the warming observed over the past 50 years is attributable to human activities." However, the projections and models that have been developed for policy makers to envisage climate change scenarios demonstrate the limits of our ability to understand the situation, let alone adapt to it. A recent review in Nature, comparing two twenty-year forecasts ironically concluded: Uncertainties therefore remain that are beyond the statistical uncertainties described in the two papers. But both sets of authors point out that the upper bound on the potential warming for 2100 may well be [End Page 144] above the IPCC figure of 5.8K under 'heavy emissions' scenarios. So policy-makers should not discount the possibility of a very warm climate considering long-range policy options. (Funnel 2001, 5) A subsequent article in Nature's Climate Change Review reveals even more concern about communicating scientific uncertainty, because models that simulate long-term climate changes cannot be tested using real... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & the Environment 8.1 (2003) 143-150 [Access article in PDF] Species Nova [To See Anew]Art as Ecology David Haley Looking Back From space, looking back at earth, we may see three key issues: the accelerating increase of the human species, the accelerating decrease of other species, and the accelerating effects of climate change. We might ask, how are we to cope with these changes creatively?That our societies tend (...) to value economics over ecology, and monoculture and agro-industry over diversity and permaculture, is certainly worthy of ethical attention. Here I want to invoke a call for integrating art as a necessary contribution to ecological intervention. I consider how artists may engage uncertainty, and how art may be used to develop new ways of seeing and "drawing." This is art for evolutionary survival, not commodification. Art that practices care, shared responsibility, and diversity in the pursuit of eco-centric cultures. Although this paper mainly references visual art forms, this should not be taken to exclude others. Here I am primarily concerned with identifying some of the possible forms of ecological or eco-art. This is art practiced by artist and inventors in the manner of the archetype of Daedalus and worthy of the name implied by the root of the word art. Rt, an ancient term from the Rg Vedas, refers to the virtuous, continuing creation of the cosmos. [End Page 143] Seeing is Believing/ Uncertainty in View The suffix species nova is ascribed by scientists to a new bacterium species, prior to the confirmation of its existence in the appropriate academic journals. The word species means "to look" and "a class of things, living organisms capable of exchanging genes, classified as a taxonomic rank below a genus and denoted by a Latin binomial." It also refers to "the visible form of each of the elements of consecrated bread and wine in the Eucharist." Nova refers to the mistaken sighting of a new star, a flash of brightness that quickly dims. Something novel is a new kind of nature, something strange or previously unknown, and novelty refers to invention. Species nova: two words that evoke ideas about innovations of visual experience and belief.I use the phrase to denote the potential for understanding a new order and evolutionary change—"to see anew." I am also aware that species nova could mean a mistaken religious experience, or a class of living things that flashes brightly and quickly dims. Uncertainty is embedded in the richness of meanings.It is ten years since the Earth Summit in Rio popularized the notion of sustainable development and introduced Agenda 21 as a strategy to achieve it. Sadly, culture and art, two of the systems that define humanity, were not mentioned among the necessary tools for building a better future.But what is sustainable development? Is it about conservation, restoration, or regeneration? Will it stop global warming and feed the poor, or is it like candyfloss—a confection of transient comfort, with no real meaning? Has it become a corrupt cultural construct, an anthropocentric myth in the vain pursuit of hope?Recently the Intergovernmental Panel on Climate Change confirmed that "most of the warming observed over the past 50 years is attributable to human activities." However, the projections and models that have been developed for policy makers to envisage climate change scenarios demonstrate the limits of our ability to understand the situation, let alone adapt to it. A recent review in Nature, comparing two twenty-year forecasts ironically concluded: Uncertainties therefore remain that are beyond the statistical uncertainties described in the two papers. But both sets of authors point out that the upper bound on the potential warming for 2100 may well be [End Page 144] above the IPCC figure of 5.8K under 'heavy emissions' scenarios. So policy-makers should not discount the possibility of a very warm climate considering long-range policy options. (Funnel 2001, 5) A subsequent article in Nature's Climate Change Review reveals even more concern about communicating scientific uncertainty, because models that simulate long-term climate changes cannot be tested using real... (shrink)

The doctorate forms the basis for academic careers and the regeneration of academia, and has increasingly become important for other sectors of society. The latter is reflected in efforts on institutional, national as well as supranational levels to change and adapt the doctoral degree to new expectations. As doctoral education is embedded in research, changes in governance and funding of research further affect the doctorate. The evaluation of the doctoral thesis appears, however, to have remained true to the academic tradition: (...) an examination committee exercising their gatekeeping in a ceremonial setting. This study sets out to explore doctoral examination committees’ evaluation practices. Insights were gained through six focus group interviews with experienced examination committee members at three large research-intensive universities in Sweden. Of particular interest is how the object of evaluation is formed, the nature of the boundary-work conducted, and variations in examination practices related to different and changing conditions for research and doctoral education. Our results show how the object of evaluation emerges through a gradual interpretation of the thesis and defence, becoming more complex and nuanced as the process of evaluation progresses from its initial stages to the final closed discussions of the committee. The finalised object of evaluation, only fully present at the conclusion of the closed meeting and hence transient in nature, encompasses the research contribution, educational achievement, and academic competence of the candidate. Furthermore, the boundary-work conducted in this process often transcends the object of evaluation to include also supervision and the local context for doctoral education and research, and hence contributes to upholding, and potential changing, norms in research fields, educational contexts, and academia at large. This extended boundary-work intensified as problems and inconsistencies were discovered during the evaluation process. The ceremonial staging underscored the gravity of the decision and the extended boundary-work. Despite changing conditions for the doctorate, our findings highlight the importance of the practice of evaluation committees, and the disciplinary communities to which they belong, for upholding and negotiating norms in academia. (shrink)

Understanding how transcription factor (TF) binding is related to gene regulation is a moving target. We recently uncovered genome‐wide evidence for a “Hit‐and‐Run” model of transcription. In this model, a master TF “hits” a target promoter to initiate a rapid response to a signal. As the “hit” is transient, the model invokes recruitment of partner TFs to sustain transcription over time. Following the “run”, the master TF “hits” other targets to propagate the response genome‐wide. As such, a TF may (...) act as a “catalyst” to mount a broad and acute response in cells that first sense the signal, while the recruited TF partners promote long‐term adaptive behavior in the whole organism. This “Hit‐and‐Run” model likely has broad relevance, as TF perturbation studies across eukaryotes show small overlaps between TF‐regulated and TF‐bound genes, implicating transient TF‐target binding. Here, we explore this “Hit‐and‐Run” model to suggest molecular mechanisms and its biological relevance. (shrink)

To meet the ecological challenge, higher education must face many challenges: the educational offer, which is currently limited in many aspects, must evolve by renewing its methods while adapting its content. An “ecological awakening” is necessary to stimulate student awareness and action. This awakening is already present in some establishments which have transformed their educational model as well as their training in order to integrate and incarnate a more holistic vision of the world. These examples are all sources of inspiration (...) that can serve as a basis for reflection to modify university courses in depth. This chapter outlines first the shortcomings of the current educational model – in terms of content and methods – drawing on the authors’ insights, mostly from France. Then, the chapter turns towards recent evolutions, be it structural or transient, as well as incentives at various levels that could contribute to a transition of higher education. (shrink)

Deciding between different voluntary movements implies a continuous control of the competition between potential actions. Many theories postulate a leading role of prefrontal cortices in this executive function, but strong evidence exists that a motor region like the primary motor cortex is also involved, possibly via inhibitory mechanisms. This was already shown during the pre-movement decision period, but not after movement onset. For this pilot experiment we designed a new task compatible with the dynamics of post-onset control to study the (...) silent period duration, a pause in electromyographic activity after single-pulse transcranial magnetic stimulation that reflects inhibitory mechanisms. A careful analysis of the SP during the ongoing movement indicates a gradual increase in inhibitory mechanisms with the level of competition, consistent with an increase in mutual inhibition between alternative movement options. However, we also observed a decreased SP duration for high-competition trials associated with change-of-mind inflections in their trajectories. Our results suggest a new post-onset adaptive process that consists in a transient reduction of GABAergic inhibition within M1 for highly conflicting situations. We propose that this reduced inhibition softens the competition between concurrent motor options, thereby favoring response vacillation, an adaptive strategy that proved successful at improving behavioral performance. (shrink)

Poland is a country of high social mobility, of a high percentage of transient population that moves from the country to the cities. These changes create numerous problems of social adaptation. Some of them arise when two different groups of different moral attitudes come in contact and realize that they differ. Although some authors believe that the Poles have highly uniform moral views and opinions, the present writer has made the claim that it is not so that village (...) population have different moral attitudes from those displayed by city inhabitants. The article supports this claim by citing findings based on a questionnaire that was filled by 500 village and 500 city inhabitants. The two populations were found to be different on at least four counts. (shrink)

Herman Daly once identified the absurdity of shipping Danish cookies to the United States; if efficiency were in fact ‘economic’, one might just e-mail the recipe, save the fuel, reduce the greenhouse gases and still enjoy the cookie. This argument playfully illustrates that resources are scarce, ideas are Inherently Not Scarce (INS) and current financial systems are inefficient and not ‘economical’. The unprecedented industry of 7.5 billion people is now concerned about the resulting scarcity and pollution of the finite resource (...) base. Until humanity shares inherently-not-scarce ideas for effectively managing what is in a steady state, scarcity and pollution will be a constant source of crisis on the landscape. Since 2004, I have made transforming colour field paintings with mud taken from the most pristine to the most toxic landscapes of northeast United States of America (NE USA). Although difficult to see individually, microbes existing within mud photosynthesize pigments. As a species grows from individual to colony, it becomes visible as pointillist pigments amass horizontal blocks of transient colour. As these bacteria express themselves (i.e., live: consume, reproduce, deplete resources, release wastes), they exhaust their habitat and create an altered landscape suitable to a successor. Like us, bacteria are bound by the law of conservation of mass; they constantly select and reject resources from the finite landscape. The resulting processes of growth and decay are intimately linked inversions resulting in beautiful transforming colourfields. As evidenced by my vibrant and literal portraits made from mud, these simple, highly adaptable, single-cell organisms craft a unique, colourful and synthetic existence. As a model system, they exhibit a viable steady state of infinite expression in a finite landscape where life and landscape is an intimate, malleable and reciprocal whole. Here I discuss the beauty of our landfill paradises, made evident by mud taken at two different kinds of landfilled ecosystems in New York City. (shrink)

This chapter provides a brief overview of the increasing importance of experimentation in the life sciences from the seventeenth century to the present day. In the wake of the Scientific Revolution initiated in physics, numerous scientists have regularly attempted to introduce experimentation and the quantification of phenomena into the life sciences. These attempts have been difficult and have systematically come up against the fact that living organisms are individuals, i.e. both totalities that are difficult to decompose and transient results (...) of an evolutionary process that gives them specific characteristics. Experimentation has thus only been possible in biology thanks to the adaptation of a mechanistic perspective to such particularities of living bodies. (shrink)

The important text of the inscription found at Vetren, in effect the oldest document from the chancellery of the Odrysian kingdom, represents a revision - adapted to the political realities of the middle of the 4th century BC - of the royal charter, which laid down, probably from its first foundation in around the middle of the 5th century BC, the legal status and the conditions of symbiosis of a Greek emporion in the sovereign territory of the Odrysian kingdom. It (...) was a convention guaranteeing the asylum of the emporion and the emporites established in Pistiros, confirming their financial transactions with the indigenous population and according extraordinary privileges to transient merchants originating from important commercial centres on the northern coast of the Aegean sea and the Black Sea. It also attests the existence of a system of conventions regulating the rights and privileges of the Greeks on Odrysian soil, similar, we imagine, to that which according to Herodotus' account of Naucratis, regulated the presence and trade of Greeks in Pharaonic Egypt. (shrink)

The characteristic temporal relationship between actions and their sensory outcomes allows us to distinguish self- from externally generated sensory events. However, the complex sensory environment can cause transient delays between action and outcome calling for flexible recalibration of predicted sensorimotor timing. Since the neural underpinnings of this process are largely unknown this study investigated the involvement of the cerebellum by means of cerebellar transcranial direct current stimulation. While receiving anodal, cathodal, dual-hemisphere or sham ctDCS, in an adaptation phase, (...) participants were exposed to constant delays of 150 ms between actively or passively generated button presses and visual sensory outcomes. Recalibration in the same and in another sensory modality was assessed in a subsequent test phase during which variable delays between button press and visual or auditory outcome had to be detected. Results indicated that temporal recalibration occurred in audition after anodal ctDCS while it was absent in vision. As the adaptation modality was visual, effects in audition suggest that recalibration occurred on a supra-modal level. In active conditions, anodal ctDCS improved sensorimotor recalibration at the delay level closest to the adaptation delay, suggesting a precise cerebellar-dependent temporal recalibration mechanism. In passive conditions, the facilitation of inter-sensory recalibration by anodal ctDCS was overall stronger and tuned to larger delays. These findings point to a role of the cerebellum in supra-modal temporal recalibration across sensorimotor and perceptual domains, but the differential manifestation of the effect across delay levels in active and passive conditions points to differences in the underlying mechanisms depending on the availability of action-based predictions. Furthermore, these results suggest that anodal ctDCS can be a promising tool for facilitating effects of temporal recalibration in sensorimotor and inter-sensory contexts. (shrink)

There are few commonalities between intraspecific aggression and predation and few convincing arguments for the conceptualisation of blood and pain as rewards for predation. Not cruelty, but ritualised intraspecific aggression is the predominant mechanism of accretion of social power and this, not cruelty, is what bestows reproductive advantages. Enjoyment of media cruelty is not reinforced by “emotional circuits” adapted to predation, but represents transient relief from culturally determined inhibition of aggression.

The phosphorelay of Bacillus subtilis, a kinase cascade that activates master regulator Spo0A ∼ P in response to starvation signals, is the core of a large network controlling the cell's decision to differentiate into sporulation and other phenotypes. This article reviews recent advances in understanding the origins and purposes of the complex dynamical behavior of the phosphorelay, which pulses with peaks of activity coordinated with the cell cycle. The transient imbalance in the expression of two critical genes caused by (...) their strategic placement at opposing ends of the chromosome proved to be the key for this pulsed behavior. Feedback control loops in the phosphorelay use these pulses to implement a timer mechanism, which creates several windows of opportunity for phenotypic transitions over multiple generations. This strategy allows the cell to coordinate multiple differentiation programs in a decision process that fosters phenotypic diversity and adapts to current conditions. (shrink)

Although Toffler has not written an in-depth philosophical analysis of social problems, he certainly has written a highly readable popular diagnosis of the phenomenon of cultural change which social philosophers should be considering, and has given a synoptic view of contemporary culture similar to Pitirim Sorokin's popular Crisis of Our Age in the forties. Toffler's thesis is "that there are discoverable limits to the amount of change that the human organism can absorb, and that by endlessly accelerating change without first (...) determining these limits, we may submit masses of men to demands they simply cannot tolerate." Future shock is, therefore, both the physical and psychological impairment caused by reluctance and inability to absorb the rapid changes that an age of discontinuity produces. Psychic distress is identified in Leon Festinger's arresting phrase, "cognitive dissonance," the rejection or denial of information that challenges preconceptions. Physical distress is analyzed by such interesting research tools as the Rahe Life-Change Units Scale which attempts to correlate change factors with physical health. The philosophic base of modern life is seen in a Heraclitean or Bergsonian flux which ontologizes change itself and sees social and political conflict inevitably provoked by rapid change confronting an older society whose substantialist structures reflect more the stable and enduring values of an older culture. It is from the vantage point of change theory that Toffler explains the contemporary turmoil in domestic, social, political, and religious realms; and although he does not employ the more formal idiom of a Vico or Spengler in the discussion of Zeitgeist, he recognizes thought and life style as even more significant than ever in a culture in which communication is so widespread and immediate. He uses the imagery of eight hundred 62-year lifetimes to illustrate man's history of the last 50,000 years, noting the comparative stability of the previous segments and the bewildering rapidity of change cycle of idea, application, and diffusion in the last sixty-year period. He analyzes progressively the accelerative thrust that creates conflict between cultures and generations; describes the typical attitudes of citizens in an Age of Transience towards time, things, places, people, organization, and ideas; and sees "modular" man as a being for whom permanence of marriage, career, educational values, and convictions yields to "temporariness." Organizations in such a climate are characterized by lateral rather than hierarchical power relationships in which "super-industrial man," committed more to his craft than to his company, assumes more decision-making responsibility in an "adhocracy" of transient values and relationships. Toffler interestingly sees bureaucracy on the decline, technology as contributing to plurality of choice rather than to standardization, and to a kinetic imagery of impermanence in aesthetics. For the most part, Toffler, the diagnostician, resists the temptation to be the pleader. His happily infrequent divagations produce less than satisfactory critiques of family life, education, and genetic engineering. It is inevitable that this book will be criticized by specialists as bewilderingly diffuse, and verging at times on science fiction; it is possible too that the strategy of "social futurism" suggested by the author will elicit less than undiluted enthusiasm, and that inexact references to Toynbee and Maritain may be questioned. But the essential purpose of this volume to give a unified vision of contemporary culture in terms of the adaptive reaction to change--all this has been admirably realized. And one feels that the author indeed possesses the vision and research tools for particularized study in the areas treated here quite generally.--R. P. M. (shrink)

Transient Truths: An Essay in the Metaphysics of Propositions provides the first book-length exposition and defense of semantic temporalism, the view that propositions are contents or semantic values that can change their truth-values across time.

The adaptive reuse of industrial heritage, a critical component in addressing radical climate change-related urban transitions, is increasingly pertinent. This paper distinguishes ‘urban transitions’ from ‘urban transformation,’ emphasizing a more gradual, adaptive approach to urban development under the pressures of climate change. It explores the repurposing of industrial buildings and spaces, maintaining their cultural and historical value while meeting current urban needs. Through a mixed-methods approach, the paper analyses how adaptive reuse contributes to sustainable urban development, examines the scale and (...) impact of such projects from local quarters to city-wide implications, and discusses the potential negative consequences, including gentrif ication. The study spans various global regions, including Europe, the United States, Latin America, Canada, and Australia, using case studies to illustrate the effectiveness of adaptive reuse in promoting sustainability, revitalizing urban areas, and preserving cultural heritage. The paper questions the viability of traditional long-term sustainable urban development strategies in the face of rapid environmental and societal changes, suggesting a potential need for paradigm shifts in urban planning. (shrink)

This paper examines the state of the field of “science and values”—particularly regarding the implications of the thesis of transient underdetermination for the ideal of value-free science, or what I call the “ideal of epistemic purity.” I do this by discussing some of the main arguments in the literature, both for and against the ideal. I examine a preliminary argument from transient underdetermination against the ideal of epistemic purity, and I discuss two different formulations of an objection to (...) this argument—an objection that requires the strict separation of the epistemic from the practical. A secondary aim of the paper is to suggest some future directions for the field, one of which is to replace the vocabulary of values that is often employed in the literature with a more precise one. (shrink)

Moral luck is a puzzling aspect of our psychology: Why do we punish outcomes that were not intended (i.e. accidents)? Prevailing psychological accounts of moral luck characterize it as an accident or error, stemming either from a re‐evaluation of the agent's mental state or from negative affect aroused by the bad outcome itself. While these models have strong evidence in their favor, neither can account for the unique influence of accidental outcomes on punishment judgments, compared with other categories of moral (...) judgment. Why might punishment be particularly sensitive to moral luck? We suggest that such sensitivity is easily understood from the broader perspective of punishment's ultimate adaptive goal: Changing others’ behavior by exploiting their capacity to learn. This pedagogical perspective accounts for the exceptional influence of outcomes on punitive sentiments and makes predictions for additional moderators of punishment. We review evidence supporting the pedagogical hypothesis of punishment and discuss fruitful directions for future research. (shrink)

A transient quantum effect is shown to occur for a superposition of stationary states. An alternative to Schrödinger's equation is considered which predicts a transient effect even for energy eigenstates.