After spinal cord injury (SCI), motoneuron death occurs at and around the level of injury which induces changes in function and organization throughout the nervous system, including cortical changes. Muscle affected by SCI may consist of both innervated (accessible to voluntary drive) and denervated (inaccessible to voluntary drive) muscle fibers. Voluntary activation measured with transcranial magnetic stimulation (VATMS) can quantify voluntary cortical/subcortical drive to muscle but is limited by technical challenges including suboptimal stimulation of target muscle relative to its (...) antagonist. The motor evoked potential (MEP) in the biceps compared to the triceps (i.e., MEP ratio) may be a key parameter in the measurement of biceps VATMS after SCI. We used paired pulse TMS, which can inhibit or facilitate MEPs, to determine whether the MEP ratio affects VATMS in individuals with tetraplegia. Ten individuals with tetraplegia following cervical SCI and ten non-impaired individuals completed single pulse and paired pulse VATMS protocols. Paired pulse stimulation was delivered at 1.5, 10, and 30 ms inter-stimulus intervals (ISI). In both the SCI and non-impaired groups, the main effect of the stimulation pulse (paired pulse compared to single pulse) on VATMS was not significant in the linear mixed-effects models. In both groups for the stimulation parameters we tested, the MEP ratio was not modulated across all effort levels and did not affect VATMS. Linearity of the voluntary moment and superimposed twitch moment relation was lower in SCI participants compared to non-impaired. Poor linearity in the SCI group limits interpretation of VATMS. Future work is needed to address methodological issues that limit clinical application of VATMS. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Causa sive ratio. La raison de la cause, de Suarez à LeibnizSteven NadlerVincent Carraud. Causa sive ratio. La raison de la cause, de Suarez à Leibniz. Paris: Presses Universitaires de France, 2002. Pp. 573. € 42,00.Over the last two decades, there has been a good deal of outstanding work on the problem of causation in early modern philosophy. Some of it has been devoted to first-order (...) questions: for example, on whether this or that thinker allows for real causal activity among finite substances (and which ones). Other studies, by contrast, have focused on second-order questions, especially the proper formulation of the causal principle itself. Vincent Carraud's book is primarily concerned with second-order questions, although it does have something to say with respect to first-order questions as well. But the depth and breadth of this study makes it much more than just another entry in the ongoing discussion over who thought what about causality among the early moderns. Carraud has a large and complex story to tell: the development of the principle of sufficient reason in the seventeenth century. In particular, he wants to know which philosophers can truly be said to have adopted that principle in its most rigorous formulation. It is both a philosophical and a historical story, and it appears in what is surely one of the most important and interesting books in early modern philosophy in recent years.Carraud directs our attention to a particular phrase that originates with Descartes but then seems to reappear (in various forms) throughout the period: causa sive ratio, "cause or reason." Every term in the phrase is subject to interpretation, of course—'cause,' 'reason' and especially 'or'—and the thesis it embodies (and a philosopher's attitude toward it) is a function of how those terms are to be understood. Carraud's interest is in what this phrase can tell us about how a select group of philosophers (primarily Descartes, Spinoza, Malebranche and Leibniz) regard the relationship between causality and intelligibility.The story begins with Suarez, the late sixteenth-century Scholastic. Suarez's contribution to the rise of the principle of sufficient reason is modest but crucial. He privileges efficient causation over all of the other Aristotelian varieties. While he still grants some explanatory role for formal, material and final causes, they have lost their status as "true" causes for Suarez; in fact, they qualify as causes only by analogy with efficient causation. As Carraud reads Suarez, the ratio causae belongs properly only to the efficient cause, since it alone can provide the reason for the existence and being of a thing.It is Descartes, however, who occupies the central role—both historically and philosophically—in Carraud's story. For it is he who truly effects the ultimate reduction (or, as Carraud puts it, unicité) of causality. In the Cartesian scheme, all but efficient causes are banished. Moreover, the efficient cause of an effect is now defined as the sufficient cause, one that explains why the effect is as it is. "La primauté et l'absoluité de la cause lui viennent de ce qu'elle rend raison de l'effet... Les causes sont d'abord les raisons (suffisantes) des effets, en quoi elles les expliquent" (199-200). Moreover, with Descartes we find a universal application of the principle of causality to all things, even to those that previously either were not regarded as sufficiently real to need a cause (the objective reality of ideas) or were regarded as standing outside the domain of causality altogether (God). It is not that God is a caused being for Descartes. Rather, the important thing is that God is, like all existing things, subject to the causal question. That is, it is legitimate to ask why God does not need a cause. And, in Carraud's account, this is where ratio comes in to its own. God is not a caused being, but there is a reason (in God's immense power) why God does not require a cause. Moreover, the only analogy we have for thinking of the way in which God's immensity forestalls God needing a cause is in terms of efficient causality itself... (shrink)

The main aim of our study was to determinate whether a repeated bout (RB) (vs. first bout [FB]) of sprint interval cycling exercise (SIE) is sufficient to mitigate SIE-induced psychological and physiological biomarker kinetics within 48 h after the exercise. Ten physically active men (age, 22.6 ± 5.2 years; VO2max, 44.3 ± 5.7 ml/kg/min) performed the FB of sprint interval cycling exercise (12 repeats of 5 s each) on one day and the RB 2 weeks later. The following parameters were (...) measured: motor performance (voluntary, electrically induced and isokinetic skeletal muscle contraction torque, and central activation ratio [CAR]); stress markers (BDNF, cortisol, norepinephrine, and epinephrine); inflammatory markers (IL-6, IL-10, and TNF-); metabolic markers (glucose and lactate); muscle and rectal temperature; cycling power output; and psychological perceptions. The average cycling power output and neuromuscular fatigue after exercise did not differ between the FB and RB. There were significant decreases in cortisol and BDNF concentration at 12 h (P < 0.05) and 24 h (P < 0.001) after the FB, respectively. The decrease in cortisol concentration observed 12 h after exercise was significantly greater after the RB (P < 0.05) than after the FB. The immune-metabolic response to the RB (vs. FB) SIE was suppressed and accompanied by lower psychological exertion. Most of the changes in psychological and physiological biomarkers in the FB and RB were closely related to the response kinetics of changes in BDNF concentration. (shrink)

Aspects of peroxisome evolution, uncoupling, carnitine shuttles, supercomplex formation, and missing neuronal fatty acid oxidation (FAO) are linked to reactive oxygen species (ROS) formation in respiratory chains. Oxidation of substrates with high FADH2/NADH (F/N) ratios (e.g., FAs) initiate ROS formation in Complex I due to insufficient availability of its electron acceptor (Q) and reverse electron transport from QH2, e.g., during FAO or glycerol‐3‐phosphate shuttle use. Here it is proposed that the Q‐cycle of Complex III contributes to enhanced ROS formation going (...) from low F/N ratio substrates (glucose) to high F/N substrates. This contribution is twofold: 1) Complex III uses Q as substrate, thus also competing with Complex I; 2) Complex III itself will produce more ROS under these conditions. I link this scenario to the universally observed Complex III dimerization. The Q‐cycle of Complex III thus again illustrates the tension between efficient ATP generation and endogenous ROS formation. This model can explain recent findings concerning succinate and ROS‐induced uncoupling. (shrink)

In the face of growing skepticism and relativism, “believe in reason” is the central message in Pope John Paul II’s Fides et Ratio. Only by the two wings of reason and faith together can the human spirit soar. The current work, Ratio et Fides, is its philosophical counterpart. It is not a watered-down introduction but a “leading-into” the heart of philosophic thinking. Firmly rooted in the phenomenological description of an ordinary artifact, a mailbox, the book uses the (...) principles involved in the description to examine key figures in the history of thought. We focus on three areas: the Soul, Morality, and God. We consider seven thinkers. Plato and Aristotle, who founded the tradition, were taken up by Augustine and Aquinas in developing their theologies. Descartes launched the distinctively modern tradition, culminating in Hegel’s systematic presentation of the whole Western tradition, philosophical and religious. More recently, Heidegger approached that tradition in terms of its hidden ground in the Mystery of Being, recalling us to meditative thinking as the secular counterpart to prayer. Armed with this background, students will be able to approach with profit the Fathers of the Church and major theologians and philosophers, past and recent. (shrink)

For Marx, work is the fundamental and central activity in human life and, potentially at least, a ful lling and liberating activity. Although this view is implicit throughout Marx’s work, there is little explicit explanation or defence of it. The fullest treatment is in the account of ‘estranged labour’ [entfremdete Arbeit] in the Economic and Philosophical Manuscripts;1 but, even there, Marx does not set out his philosophical assumptions at length. For an understanding of these, one must turn to Hegel. (...) Marx is quite explicit about his debt to Hegel in this respect. (shrink)

The book is dedicated to the theoretical problems concerning ratio legis. In the contexts of legal interpretation and legal reasoning, the two most important intellectual tools employed by lawyers, ratio legis would seem to offer an extremely powerful argument. Declaring the ratio legis of a statute can lead to a u-turn argumentation throughout the lifespan of the statute itself – in parliament, or in practice during court sessions, when it is tested against the constitution. Though the (...) class='Hi'>ratio legis argument is widely used, much about it warrants further investigation. On the general philosophical map there are many overlapping areas that concern different approaches to human rationality and to the problems of practical reasoning. Particular problems with ratio legis arise in connection with different perspectives on legal philosophy and theory, especially in terms of the methods that lawyers use for legal interpretation and argumentation. These problems can be further subdivided into particular aspects of activities undertaken by lawyers and officials who use the ratio legis in their work, and the underlying theories. In short, this book examines what ratio legis is, what it could be, and its practical implications. (shrink)

This dissertation sets out to discuss some features of Spinoza's concepts of conatus and causation, through a discussion of the overall structure of the Ethics. ;The major portion of the dissertation is devoted to Spinoza's method, as employed in the Ethics, the notorious geometric method. I argue against the traditional reading of the method as a simple geometric device, and for a position which emphasizes how the method itself leads the reader to come to the highest kinds of knowledge. This (...) is accomplished both with reference to Spinoza's early modern contemporaries, and older Jewish antecedent. ;The reconsideration of method leads, respectively, to a discussion of the conatus in Spinoza's philosophy, and the centrality of adequate cause. The conatus is viewed as a way of making Spinoza's philosophy jibe with our phenomenal world, and to show how we express ourselves through the metaphysical, physical and rational structures detailed in the first two books of the Ethics. Hence it allows us to view the work itself as a way of coming to terms with, and moving towards, knowledge sub specie aeternitatis. ;The centrality of adequate cause similarly helps us to see that Spinoza's interest is not so much in detailing the metaphysical structure of the world, but teaching us to express ourselves in and through it. That is the ultimate goal of the method itself. (shrink)

When the stored representation of the meaning of a stimulus is accessed through the processing of a sensory input it is maintained in an activated state for a certain amount of time that allows for further processing. This semantic activation is generally accompanied by conscious identification, which can be demonstrated by the ability of a person to perform discriminations on the basis of the meaning of the stimulus. The idea that a sensory input can give rise to semantic (...) class='Hi'>activation without concomitant conscious identification was the central thesis of the controversial research in subliminal perception. Recently, new claims for the existence of such phenomena have arisen from studies in dichotic listening, parafoveal vision, and visual pattern masking. Because of the fundamental role played by these types of experiments in cognitive psychology, the new assertions have raised widespread interest. (shrink)

A central aspect of people's beliefs about the mind is that mental activities—for example, thinking, reasoning, and problem solving—are interrelated, with some activities being kinds or parts of others. In common-sense psychology, reasoning is a kind of thinking and reasoning is part of problem solving. People's conceptions of these mental kinds and parts can furnish clues to the ordinary meaning of these terms and to the differences between folk and scientific psychology. In this article, we use a new technique (...) for deriving partial orders to analyze subjects' decisions about whether one mental activity is a kind or part of another. The resulting taxonomies and partonomies differ from those of common object categories in exhibiting a converse relation in this domain: One mental activity is a part of another if the second is a kind of the first. The derived taxonomies and partonomies also allow us to predict results from further experiments that examine subjects' memory for these activities, their ratings of the activities' importance, and their judgments about whether there could be "possible minds" that possess some of the activities but not others. (shrink)

This article examines what is known about the cognitive science of working memory, and brings the findings to bear in evaluating philosophical accounts of central cognitive processes of thinking and reasoning. It is argued that central cognition is sensory based, depending on the activation and deployment of sensory images of various sorts. Contrary to a broad spectrum of philosophical opinion, the central mind does not contain any workspace within which goals, decisions, intentions, or non-sensory judgments can (...) be active.Introduction: philosophers’ commitmentsMost philosophers believe that our so-called “personal-level” propositional attitudes—our personal judgments, beliefs, goals, values, decisions, and intentions—are consciously accessible. Many will also allow, of course, that some of the processing that takes place within our perceptual faculties is inaccessible to us; and many will grant the possibility of unconscious attitudes, as well as processes of inference and decision mak. (shrink)

Activity theory is an interdisciplinary approach to human sciences that originates in the cultural-historical psychology school, initiated by Vygotsky, Leont'ev, and Luria. It takes the object-oriented, artifact-mediated collective activity system as its unit of analysis, thus bridging the gulf between the individual subject and the societal structure. This volume is the first comprehensive presentation of contemporary work in activity theory, with 26 original chapters by authors from ten countries. In Part I of the book, central theoretical issues are discussed (...) from different points of view. Some topics addressed in this part are epistemology, methodology, and the relationship between biological and cultural factors. Part II is devoted to the acquisition and development of language - a theme that played a central role in the work of Vygotsky and Luria. This part includes a chapter that analyzes writing activity in Japanese classrooms, and an original case study of literacy skills of a man with cerebral palsy. Part III contains chapters on play, learning, and education, and part IV addresses the meaning of new technology and the development of work activities. The final part covers issues of therapy and addiction. (shrink)

This paper argues that current pragmatic theories fail to describe common ground in its complexity because they usually retain a communication-as-transfer-between-minds view of language, and disregard the fact that disagreement and egocentrism of speaker-hearers are as fundamental parts of communication as agreement and cooperation. On the other hand, current cognitive research has overestimated the egocentric behavior of the dyads and argued for the dynamic emergent property of common ground while devaluing the overall significance of cooperation in the process of verbal (...) communication. The paper attempts to eliminate this conflict and proposes to combine the two views into an integrated concept of common ground, in which both core common ground and emergent common ground converge to construct a dialectical socio-cultural background for communication.Both cognitive and pragmatic considerations are central to this issue. While attention explains why emergent property unfolds, intention explains why presumed shared knowledge is needed. Based on this, common ground is perceived as an effort to converge the mental representation of shared knowledge present as memory that we can activate, shared knowledge that we can seek, and rapport, as well as knowledge that we can create in the communicative process. The socio-cognitive approach emphasizes that common ground is a dynamic construct that is mutually constructed by interlocutors throughout the communicative process. The core and emergent components join in the construction of common ground in all stages, although they may contribute to the construction process in different ways, to different extents, and in different phases of the communicative process. (shrink)

This paper argues that current pragmatic theories fail to describe common ground in its complexity because they usually retain a communication-as-transfer-between-minds view of language, and disregard the fact that disagreement and egocentrism of speaker-hearers are as fundamental parts of communication as agreement and cooperation. On the other hand, current cognitive research has overestimated the egocentric behavior of the dyads and argued for the dynamic emergent property of common ground while devaluing the overall significance of cooperation in the process of verbal (...) communication. The paper attempts to eliminate this conflict and proposes to combine the two views into an integrated concept of common ground, in which both core common ground and emergent common ground converge to construct a dialectical socio-cultural background for communication.Both cognitive and pragmatic considerations are central to this issue. While attention explains why emergent property unfolds, intention explains why presumed shared knowledge is needed. Based on this, common ground is perceived as an effort to converge the mental representation of shared knowledge present as memory that we can activate, shared knowledge that we can seek, and rapport, as well as knowledge that we can create in the communicative process. The socio-cognitive approach emphasizes that common ground is a dynamic construct that is mutually constructed by interlocutors throughout the communicative process. The core and emergent components join in the construction of common ground in all stages, although they may contribute to the construction process in different ways, to different extents, and in different phases of the communicative process. (shrink)

This paper develops a methodology for using Activity Theory (AT) to investigate pedagogical practices in primary school mathematics classrooms by selecting object-oriented pedagogical activity as the unit of analysis. While an understanding of object-oriented activity is central to Activity Theory (AT), the notion of object is a frequently debated and often misunderstood one. The conceptual confusion surrounding the object arises both from difficulties related to translating the original Russian conceptualisation of object-oriented activity into English as well as from the (...) different interpretations of the object currently in use within two contemporary approaches in activity theory. This paper seeks to clarify understandings of the object by exploring notions of object oriented activity. To this end, the paper traces the historical development of the object through Leontiev (1978; 1981) and Engeström’s (1987; 1999) expansion of Vygotsky’s original triadic understanding of object oriented activity. Drawing on Basil Bernstein’s (1996) notion of evaluative criteria as those rules that transmit the criteria for the production of a legitimate text, the paper goes on to elaborate a methodology for using AT to analyse observational data by developing the notion of “evaluative episodes” as pedagogical moments in which the pedagogical object is made visible. Findings indicate that an evaluative episode can serve as an analytical space in which the dynamism of an activity system is momentarily frozen, enabling one to model human activity in the system under investigation and, hence, in this study, to understand pedagogy in context. (shrink)

The well-known game of chess has traditionally been modeled in artificial intelligence studies by search engines with advanced pruning techniques. The models were thus centered on an inference engine manipulating passive symbols in the form of tokens. It is beyond doubt, however, that human players do not carry out such processes. Instead, chess masters instead carry out perceptual processes, carefully categorizing the chunks perceived in a position and gradually building complex dynamic structures to represent the subtle pressures embedded in the (...) positions. In this paper we will consider two hypotheses concerning the underlying subcognitive processes and architecture. In the first hypothesis, a multiple-leveled chess representational structure is presented, which includes distance graphs (with varying levels of quality) between pieces, piece mobilities, and abstract roles. These representational schemes seem to account for numerous characteristics of human player’s psychology. The second hypothesis concerns the extension of the architecture proposed in the Copycat project as central for modeling the emergent intuitive perception of a chess position. We provide a synthesis on how the postulated architecture models chess intuition as an emergent mixture of simultaneous distance estimations, chunk perceptions, abstract role awareness, and intention activations. This is an alternative model to the traditional AI approaches, focusing on the philosophy of active symbols. (shrink)

The relative reinforcing value of food measures how hard someone will work for a high-energy-dense food when an alternative reward is concurrently available. Higher RRV for HED food has been linked to obesity, yet this association has not been examined in low-income preschool-age children. Further, the development of individual differences in the RRV of food in early childhood is poorly understood. This cross-sectional study tested the hypothesis that the RRV of HED to low-energy-dense food would be greater in children with (...) obesity compared to children without obesity in a sample of 130 low-income 3- to 5-year-olds enrolled in Head Start classrooms in Central Pennsylvania. In addition, we examined individual differences in the RRV of food by child characteristics and food security status. The RRV of food was measured on concurrent progressive-ratio schedules of reinforcement. RRV outcomes included the last schedule reached for cookies and fruit, the breakpoint for cookies in proportion to the total breakpoint for cookies and fruit combined, and response rates. Parents completed the 18-item food security module to assess household food security status and the Behavioral Activation System scale to assess reward sensitivity. Pearson’s correlations and mixed models assessed associations between continuous and discrete child characteristics with RRV outcomes, respectively. Two-way mixed effects interaction models examined age and sex as moderators of the association between RRV and Body Mass Index z-scores. Statistical significance was defined as p < 0.05. Children with obesity had a greater cookie Pmax [F = 4.95, p = 0.03], higher RRV cookie [F = 4.28, p = 0.04], and responded at a faster rate for cookies [F = 17.27, p < 0.001] compared to children without obesity. Children with higher cookie response rates had higher BMIZ ; and RRV cookie was positively associated with BMIZ for older children and boys, but not younger children or girls. The RRV of food did not differ by household food security status. Low-income children with obesity showed greater motivation to work for cookies than fruit compared to their peers without obesity. The RRV of HED food may be an important contributor to increased weight status in boys and future research is needed to better understand developmental trajectories of the RRV of food across childhood. (shrink)

The study aim was 2-fold (i) to describe and compare the in-season variations of acute: chronic workload ratio (ACWR) coupled, ACWR uncoupled, and exponentially weighted moving average (EWMA) through session-rated perceived exertion (s-RPE), total distance (TD), high-speed running distance (HSRD), and sprint distance across different periods of a professional soccer season (early, mid, and end-season) between starters and non-starters; (ii) to analyze the relationship the aforementioned measures across different periods of the season for starters and non-starters. Twenty elite soccer (...) players (mean ± SD age, 29.4 ± 4.4 y; height, 1.8 ± 0.1 m; and body mass, 74.8 ± 2.3 kg). They were divided into starter and non-starter groups and were evaluated for 20 weeks. ACWR had general changes throughout the season. At the beginning and end of the mid-season, the highest ACWR was observed in three parameters: s-RPE, TD, and HSRD. ACWR and EWMA through sprint distance were higher at the beginning of the early-season than at any other time of the season.The ACWR coupled of s-RPE shows a significant higher value for non-starters than starters (p = 0.015;g = −1.01 [−1.98, −0.09]) and the ACWR coupled of TD shows a significant higher value for starters than non-starters in early-season (p < 0.01;g = 3.01 [1.78, 4.46]) and shows a significant higher value for non-starters than starters in mid-season (p < 0.01;g = −2.52 [−3.83, −1.39]), and end-season (p < 0.01;g = −2.57 [−3.89, −1.43]). While the EWMA of TD shows a significant higher value for starters than non-starters in early-season (p < 0.01;g = 2.25 [1.17, 3.49]) and mid-season (p < 0.01;g = 2.42 [1.31, 3.71]), and shows a significant higher value for non-starters than starters in end-season (p < 0.01;g = −2.23 [−3.47, −1.16]). Additionally, we found some correlations between external and internal load measures during three periods of the in-season. The study’s main finding was that the indexes of ACWR and EWMA were useful to detect differences between period and between playing status with the exception for the sprint variable. In addition, the necessary work for non-starter players’ improvement is not done during training, and these players lose their readiness as the season progresses. Consequently, these players perform poorly during the match. Therefore, coaches and their staff should consider devising new activities to keep non-starter players physically fit. This deficit must be accounted for in training because they compete in fewer matches and have less burden than starters. (shrink)

The aim of my dissertation is to investigate how universal concepts are formed according to the later medieval Franciscan theologian Peter Auriol (d. 1322). Specifically, in the dissertation I inquiry into the relation between Auriol's ontology - according to which only individuals, and not universals, have real, extra-mental existence - and his philosophical psychology, a study of how extra-mental particulars can give rise to universal concepts, according to Auriol's view. In the past academic year I refined the topic of my (...) PhD thesis in two ways : first, I have delineated the definitive table of content ; second, I have wrote down the results of my research. The thesis comprises two volumes. The second one contains a collation of Peter Auriol's,Reportatio II, d. 9, qq. 2 - 3. The text has been obtained by confronting two manuscripts, considered as the exemplars of the two main families that convey his Second Book of the Sentences: ms. Firenze, Biblioteca nazionale centrale, ms. conv. soppr. A.3.120 (Fb); (iii) il ms. Padova, Biblioteca Antoniana, ms. 161 scaff. IX (Pg). The first volume, instead, has been divided into five chapters: the first two offer a historical introduction, while the remaining three are dedicated to the study of Auriol's doctrine, starting from the analysis of the text proposed in the collation, then extending the investigation to all the documentary heritage available relating to the Franciscan master. The first chapter provides a survey of the main theories of the universals of the early fourteenth century, taking into account in particular the opinions of those thinkers who, like Duns Scotus, in addition to marking a philosophical era, have been significant for Auriol's developing of his theory of universals. These are: John Duns Scotus, Henry of Harclay, Walter Bulery and Hervaeus Natalis. In order to properly understand the philosophical proposal of the Doctor facundus, it is necessary to know how it fits into a debate that in the academic debate of the fourteenth century. The second chapter is mainly aimed at the identification of the sources of Rep. II, d. 9, qq. 2 - 3. In the quaestio secunda, Auriol deals with the foundation of the universals. In a.1, he discusses the opinion of multiwho he labels as 'platonic'. We tried, therefore, to detect the targets of his criticism. Burley, Wylton, Bacon, Duns Scotus have been identified as possible addresses. In a. 2 of the same question, Auriol analyzes the position of Duns Scotus on the common nature. It has been then hypothesized that the two articles - aa. 1-2 - has to be considered as a general presentation and specific case of it; as a thesis common to several forms of realism and the realism of one of its most important interpreters. The third chapter focuses Auriol's criticism of the different forms of realism reported in a. 1 and of Duns Scotus's theory, as it is found in a. 2. In both cases, Auriol reproaches the realists for breaking the unity of substance, into a multiplicity of formalitatesreally occurring in reand corresponding to the concepts of genus and difference. On the contrary, Auriol maintains that universal concepts have no unity in the extra-mental reality. Only individuals really exist and numerical unity the only fully existing unity. As a consequence, the unity of the universal concept is just similitudinaria,that is only given a concept. Successively, the criticisms that Auriol makes to the principle of individuation are considered. Generally speaking, everything that exists, insofar as it exists, is singular, according to him. It is a primitive fact and it is not, therefore, necessary to search for the causes of its individuation. Thus, mirroring the structure of the quaestio secunda, in q. 3, Auriol discusses, in the first place, Duns Scotus's position and secondly a group of theories, arisen during the scholastic debate between the end of the thirteenth and the beginning of the fourteenth century. Interestingly, to reconstruct this set of doctrines, Auriol follows almost literally the reconstruction that Scotus himself makes of the same theories in his Ordinatio. Now, relying on the assumption that everything that exists is individual, Auriol gives shape to the notions of individuality and singularity and their mutual difference. This is one of the hubs of the dissertation. According to Auriol, a singularity is an entity that does not admit the existence of other realities that can be considered as similar with it. In this sense, God is the only authentic singularity. Ordinary reality, on the other hand, is made up of individualities. An individuality is an entity that, being finite, does not exhaust in itself the totality of the species to which it belongs (as far as the species as such exists only in virtue of an act of the intellect), admits the existence of other realities conceivable as similar with it. Thus, inasmuch as reality is made up of individuals or individualities, the mind is able to form the corresponding universal concepts. Being finite, for Auriol, is the condition of the validity of universals. In this respect, the relation between the concept of individuality and that of singularity is taken into account. Subsequently, we analyze the function of the category of Quantity, as it is related to individuality. According to Auriol, Quantity has no individuating capacity. At most, in bodily substances, it functions as principle of distinction. Being, in fact, discrete realities, a material substance spatially ends where another one begins. The fourth chapter is a kind of juncture between the third one, in which the structure of the concrete individual is analyzed, and the fifth one, in which the cognitive side of the process of concept formation is discussed. What is discussed here are the rationes. According to Auriol, the rationesare the basic units that constitute the quiddity of each individual and serve to direct our thought to form certain concepts. Each concept is the concept of a ratio,indeed. In this respect, Auriol claims that, say, Socrates has the rationes substance, corporeality, sensitivity, rationality. Additionally, rationes of the same type occurring in different objects are "maximally similar" (simillimae). For example, the rationesof Socrates are utterly similar with those of Plato (Cf. Scriptum, d. 2, q. 1, a. 4). Therefore, although these rationes are non-universal characteristics - inasmuch as a ratio belongs to one and only one individual - due to their maximal similarity they do count as the extramental ground for our general concepts (Cf.II Sent., d. 9, q. 3, a. 1). According to these premises, Auriol can hold that different singulars can be mutually highly similar, without participating in the same common nature (Cf. II Sent., d. 9, q. 3, a. 3).At the same time, it is relevant to note these rationesdo not compromise the unity of an existing particular. Rather each ratiocoagulates into each other giving birth to the individual's ultimate ratio. This final ratiois an indivisible ratio (ratio atoma), which cannot be further specified or divided (II Sent., d. 9, q. 3). According to Auriol, then, the rationesqua rationesdo not exist in extra-mental reality. Rather, the exist as such only in virtue of an act of the intellect. This means that they have an ambiguous being. On the one hand, they indicate a nature that cannot be altered by the intellect. On the other, the need the mind's activity to exist as rationes. According to Auriol, therefore, the rationesare independent of any cognitive act, with regard to the content they express, while they depend on mind's activity with regard to their unity and their existence. Now, the opaqueness concerning the ontological consistency of rationesdirectly depends on Auriol's understanding of cognition. Chapter five mainly deals with the different stages of the process of formation of the universal concept. In this respect, the notion of impressiois what is firstly analyzed. The impressionescan be considered, for Auriol, as the rationesthat are 'deposited' in the intellect and constitute, in cooperation with the cognitive faculty, what the Franciscan theologian calls the actus intellectus. The intellectual act, according to Auriol, is an entity composed of the impressed similarity of the object and the intellectual power, in fact. Moreover, in his view, it is really identical to the intelligible species. Now, the identity that the Franciscan theologian establishes between these two noetic tools, which were traditionally considered as distinct, imposes a reinterpretation of the notion of species. Coinciding with the act, the species can no longer be considered as an entity juxtaposed to it, deputed to the activation of the cognitive process performed by the intellect. Indeed, all those theories of universal concepts that add other noetic tools to the act, be they a species, a quality, or something else, would necessarily compromise intellection, preventing it from having acquaintance with extra-mental reality. According to Auriol, considering intellectual cognition as a connotation allows us to avoid such inconveniences. According to this view, the intellectual cognition must be regarded as an activity that poses nothing but to allow something to appear to the cognizer. In this respect, the concept, for Auriol, is nothing but the real object qua appearingto the intellect, fully identical with the intellectual act in recto,while denominatively distinct in obliquo. In this perspective, the definition of intellection that the Franciscan theologian proposes is analyzed, trying, in particular, to determine the ontological status of the concept and its epistemological function. In conclusion, with this study we have tried to give an account of Auriol's philosophical attitude, of the scope of his theory of universals, focusing on the relationship between ontology and philosophical psychology. Using Auriol's texts and specifically the collation of Rep. II, d. 9, qq. 2 - 3, the answers to these questions were searched for in the words of the Franciscan theologian himself. The picture emerged is that of an autonomous, critical thinker, but perfectly inserted in the historical context in which he lives. A thinker who places himself, so to speak, halfway between Duns Scotus's realism and Ockham's nominalism, nevertheless succeeding, albeit with some opacity, in balancing an ontology in which the metaphysical priority is granted only to the individual and the universal concepts have a solid foundation and validity. (shrink)

This book urges educational institutions to contemplate the harm they have caused to individual and society by their tragic suppression of the energy essential to the flowering of the mind's full potential. No more strident and uncompromising a voice is to be found on this topic than Whitehead's, in _The Aims of Education and Other Essays_. Walker's interpretation of these essays is set in a story of the lives of several teachers, education students, parents, and a professor. Whitehead's presence is (...) conjured among them as an uncomfortable and challenging gadfly. The philosophic depth is made widely accessible through the conversational language of imaginary journals and dialogues. This strategy also enables Walker to demonstrate the neglected power of dialogic pedagogy, and to suggest its centrality in the realization of Whiteheadian aims. The dialogues show a group of people curiously energized by an inquiry in which their stereotypical foundations are crumbling under the combined impact of focused dialogue and the brilliance of Whitehead's counterpoint. Their creative vitality of mind is shaken out of the narcosis of ingrained routines and secondhand ideas, and they discover the forgotten power of revitalizing outlook and action with an individual discernment of meaning, importance, and truth. They have immediately experienced the very quality of mind and its manner of cultivation Whitehead insists upon. This is intelligence enriching life with its full and interweaving spectrum of intellectual, aesthetic, ethical, and spiritual sensitivities. (shrink)

Artificial Intelligence, in press. Abstract: For some time we have been developing, and have had significant practical success with, a time-sensitive, contradiction-tolerant logical reasoning engine called the active logic machine (ALMA). The current paper details a semantics for a general version of the underlying logical formalism, active logic. Central to active logic are special rules controlling the inheritance of beliefs in general (and of beliefs about the current time in particular), very tight controls on what can be derived from (...) direct contradictions (P &￢P), and mechanisms allowing an agent to represent and reason about its own beliefs and past reasoning. Furthermore, inspired by the notion that until an agent notices that a set of beliefs is contradictory, that set seems consistent (and the agent therefore reasons with it as if it were consistent), we introduce an “apperception function” that represents an agent’s limited awareness of its own beliefs, and serves to modify inconsistent belief sets so as to yield consistent sets. Using these ideas, we introduce a new definition of logical consequence in the context of active logic, as well as a new definition of soundness such that, when reasoning with consistent premises, all classically sound rules remain sound in our new sense. However, not everything that is classically sound remains sound in our sense, for by classical definitions, all rules with contradictory premises are vacuously sound, whereas in active logic not everything follows from a contradiction. (shrink)

Discussions in social psychology overlook an important way in which biases can be encoded in conceptual representations. Most accounts of implicit bias focus on ‘mere associations’ between features and representations of social groups. While some have argued that some implicit biases must have a richer conceptual structure, they have said little about what this richer structure might be. To address this lacuna, we build on research in philosophy and cognitive science demonstrating that concepts represent dependency relations between features. These relations, (...) in turn, determine the centrality of a feature f for a concept C: roughly, the more features of C depend on f, the more central f is for C. In this paper, we argue that the dependency networks that link features can encode significant biases. To support this claim, we present a series of studies that show how a particular brilliance-gender bias is encoded in the dependency networks which are part of the concepts of female and male academics. We also argue that biases which are encoded in dependency networks have unique implications for social cognition. (shrink)

This paper explores the concept of _sensorimotor activity_ that is central to the enactive model of visual perception developed in Alva Noë’s book, _Action in Perception_. The appeal to sensorimotor activity is, I shall argue, subject to a dilemma. On one interpretation, such activity presupposes representational states, and therefore is unable to aid us in the project of understanding how an organism is able to represent the world. On the other interpretation, sensorimotor activity fails to accommodate the essential normativity (...) of representational states, and is therefore also unable to aid us in the project of understanding representation. The solution, I argue, lies in a new conception of sensorimotor activity, according to which such activity is normative, but where this normativity is not inherited from prior representational states. (shrink)

The author of this review as one of CEUPES founders presents basic ideas and short history of the Society, which was founded in 2011. Its activity aims at integration of the specialists' interaction from different humanities and members of society who are interested in cooperation in educational studies in Central Europe. The practical activity of the Society includes: identifying the possibility to use the philosophy of education in formation of students' thinking in universities, exchange of views and ideas on (...) contemporary problems of education in the region, cooperation between editors of scientific journals, organization of international scientific conferences. The author informs on the activities of the leading centers of the Society, results of international cooperation and presents the prospects of CEUPES activity. (shrink)

Lifelong premature ejaculation (LPE) is a common male sexual dysfunction. Lack of active control for rapid ejaculation brought great distress to sexual harmony, and even fertility. Previous neurophysiology studies revealed an ejaculation-related control mechanism in the brain. However, it remains unclear whether this inhibitory network is altered in LPE patients. The present study investigated the central inhibitory network function of LPE patients by using stop signal task-related functional magnetic resonance imaging and resting-state functional connectivity analysis. The results showed no (...) difference in task-related behavioral performance or neural activation during response inhibition between LPE patients and controls. However, LPE patients showed a significantly different correlation pattern between the stop signal reaction time (SSRT) and left inferior frontal gyrus activation during successful inhibition, in which a typical negative correlation between SSRT and the activation was completely disappeared in patients. In addition, using the left inferior frontal gyrus as a seed, patients showed weaker functional connectivity between the seed and two areas (left dental nucleus and right frontal pole) compared with controls. These data suggest that LPE patients have an abnormal brain control network, which may contribute to the reduced central control of rapid ejaculation. This study provides new insights into the neural mechanism of LPE involving the central inhibitory network, which may offer an underlying intervention target for future treatment. (shrink)

Memory is the least studied dimension of Augustine's psychological trinity of memory-intellect-will. This book explores the theme of 'memory' in Augustine's works, tracing its philosophical and theological significance. The first part explores the philosophical history of memory in Plato, Aristotle, and Plotinus. The second part shows how Augustine inherits this theme and treats it in his early writings. The third and final part seeks to show how Augustine's theological understanding of Christ draws on and resolves tensions in the theme of (...) memory. The place of memory in the theological anthropology of Augustine has its roots in the Platonic epistemological tradition. Augustine actively engages with this tradition in his early writings in a manner that is both philosophically sophisticated and doctrinally consistent with his later, more overtly theological writings. From the Cassiacum dialogues through De musica, Augustine points to the central importance of memory: he examines the power of the soul as something that mediates sense perception and understanding, while explicitly deferring a more profound treatment of it until Confessions and De trinitate. In these two texts, memory is the foundation for the location of the Imago Dei in the mind. It becomes the basis for the spiritual experience of the embodied creature, and a source of the profound anxiety that results from the sensed opposition of human time and divine time (aeterna ratio). This tension is contained and resolved, to a limited extent, in Augustine's Christology, in the ability of a paradoxical incarnation to unify the temporal and the eternal (in Confessions 11 and 12), and the life of faith (scientia) with the promised contemplation of the divine (sapientia, in De trinitate 12-14). (shrink)

Mammalian AMP‐activated protein kinase is the central component of a protein kinase cascade which inactivates three key enzymes involved in the synthesis or release of free fatty acids and cholesterol inside the cell. The kinase cascade is activated by elevation of AMP, and perhaps also by fatty acid and cholesterol metabolites. The system may fulfil a protective function, preventing damage caused by depletion of ATP or excessive intracellular release of free lipids, a type of stress response. Recent evidence suggests (...) that it may have been in existence for at least a billion years, since a very similar protein kinase cascade is present in higher plants. This system therefore represents an early eukaryotic protein kinase cascade, which is unique in that it is regulated by intracellular metabolites rather than extracellular signals or cell cycle events. (shrink)

Background Since 2010 the People’s Republic of China has been engaged in an effort to reform its system of organ transplantation by developing a voluntary organ donation and allocation infrastructure. This has required a shift in the procurement of organs sourced from China’s prison and security apparatus to hospital-based voluntary donors declared dead by neurological and/or circulatory criteria. Chinese officials announced that from January 1, 2015, hospital-based donors would be the sole source of organs. This paper examines the availability, transparency, (...) integrity, and consistency of China’s official transplant data. Methods Forensic statistical methods were used to examine key deceased organ donation datasets from 2010 to 2018. Two central-level datasets — published by the China Organ Transplant Response System and the Red Cross Society of China — are tested for evidence of manipulation, including conformance to simple mathematical formulae, arbitrary internal ratios, the presence of anomalous data artefacts, and cross-consistency. Provincial-level data in five regions are tested for coherence, consistency, and plausibility, and individual hospital data in those provinces are examined for consistency with provincial-level data. Results COTRS data conforms almost precisely to a mathematical formula while Central Red Cross data mirrors it, albeit imperfectly. The analysis of both datasets suggests human-directed data manufacture and manipulation. Contradictory, implausible, or anomalous data artefacts were found in five provincial datasets, suggesting that these data may have been manipulated to enforce conformity with central quotas. A number of the distinctive features of China’s current organ procurement and allocation system are discussed, including apparent misclassification of nonvoluntary donors as voluntary. Conclusion A variety of evidence points to what the authors believe can only be plausibly explained by systematic falsification and manipulation of official organ transplant datasets in China. Some apparently nonvoluntary donors also appear to be misclassified as voluntary. This takes place alongside genuine voluntary organ transplant activity, which is often incentivized by large cash payments. These findings are relevant for international interactions with China’s organ transplantation system. (shrink)

In New Essays on Human Understanding, book II, chapter xxi Leibniz presents an interesting picture of the human mind as not only populated by perceptions, volitions and appetitions, but also by endeavours. The endeavours in question can be divided to entelechy and effort; Leibniz calls entelechy as primitive active forces and efforts as derivative forces. The entelechy, understood as primitive active force is to be equated with a substantial form, as Leibniz says: “When an entelechy – i.e. a primary or (...) substantial endeavour – is accompanied by perception, it is a soul” (NE II, xxi, §1; RB, 170). What about efforts, then? One is certainly the will. In NE, II, xxi, §5 Leibniz argues that volition is the effort (conatus) to move towards what one finds good and away from what one finds bad and that this endeavor arises from the perceptions we are aware of. As an endeavour results in action unless it is prevented, from will (which is always directed to the good) and power together follows action. However, this is not so simple. Leibniz argues that there is also a second class of efforts: “There are other efforts, arising from insensible perceptions, which we are not aware of; I prefer to call these ‘appetitions’ rather than volitions” (NE II, xxi, §5; RB, 173). Although there are appetitions of which one can be aware, usually these appetitions arise from the insensible petite perceptions and are consequently affecting us subconsciously. Now, although all minute perceptions are confused perceptions, they are always related to pleasure and displeasure and also to perfection and imperfection. From this follows that there can be different efforts present in the soul at the same time: the will which is directed to apperceived good and several separate appetitions which lead to different goals, both to those which bring about perfection and pleasure of the mind (joy) and those which bring about displeasure and imperfection (sorrow). These efforts are not only in conflict with each other but may also be in conflict with entelechy. A typical case is perceiving a sensual pleasure. Our entelechy which is always directed to final causes (perfection) may be in conflict with several different appetitions which are related in different ways to the sensual pleasure in question. If our understanding is developed enough, our will resists the temptation posed by the pleasure (agreeing with entelechy), but if the temptation is too strong, the appetitions outweigh the will and the resulting action bring about imperfection and sorrow as it is related to imperfection. In this paper I will argue that deliberation in the human soul is a battle of different endeavors described above: the entelechy in the soul strives according to its law-of-the-series towards its telos (perfection) and the will accompanies it by being automatically directed to the good. This thrust towards the apparent good is aided or hindered by the appetitions which can be thought as derivative forces in the Leibnizian dynamics. Depending on whether the predominant appetitions are related to good or bad desires, the deliberation succeeds or fails in achieving the real good which is the goal of human deliberation. The successs can be facilitated beforehand by developing our understanding so that we are less easily swept away by the derivative forces (NE II, xxi, §19). A central role in this task is played by strong willing. As Martha Bolton has noted in her recent paper, an essential feature of the basic, standing endeavors is that they are continuous – although the power balance in the soul changes from moment to moment, something lingers from our previous volitions. That is why Leibniz argues that we pave way for the future deliberations by our previous voluntary actions (NE II, xxi, §23). In contrast, the appetitions are temporary, fliegende Gedanken as Leibniz says in NE II, xxi, §12. Therefore there is a constant, always changing power balance between two kinds of endeavors in the soul: primitive active force versus derivative forces. I will argue that the behavior of the forces in the soul can be understood with a vectorial model which is related to Leibniz’s early ideas of calculus of variations and which was anticipated by Arnauld and Nicole’s Port-Royal Logic. The central idea in the model is that the options are in tension towards each other and the ratio between them at each moment determines the consequent outcome. The proper relationship between the endeavors is not a simple balance, two options which exhaust each other, but a case where different efforts complement each other: “Since the final result is determined by how things weigh against one another, I should think it could happen that he most pressing disquiet did not prevail; for even If it prevailed over each of the contrary endeavours taken singly, it may be outweighed by all of them together.” Leibniz continues : “Everything which then impinges on us weighs in the balance and contributes to determining a resultant direction, almost as in mechanics” (NE II, xxi, §40; RB, 193). The different endeavors can be understood as vectors leading to different directions and the end result is a certain direction that deliberation takes. The dynamical tension between the different endeavors presents a situation where everything affects everything and the following direction, the resulting volition follows more or less automatically. In Theodicy, §325 Leibniz describes the deliberation as follows: “One might, instead of the balance, compare the soul with a force that puts forth an effort on various sides simultaneously, but which acts only at the spot where action is easiest or there is least resistance” (Huggard, 322) This kind of dynamical tension can be understood in terms of the calculus of variations where there are several possible variations available but where the dynamics of the situation results in the decision taking the “easiest” route which is more or less objectively good depending on the level of the deliberator’s understanding. In his comments to Bayle’s note L of “Rorarius” Leibniz says: “The soul, even though it has no parts, has within it, because of the multitude of representations of external things, or rather because of the representation of the universe lodged within it by the creator, a great number, or rather an infinite number, of variations (Woolhouse & Francks (ed.), ‘New System’ and Associated Texts, 101). This kind of deliberation is comparable to God’s choice of the best world with the difference that God’s understanding is infinite which again results in the fact that the choice is the best possible. Whereas in nature the easiest route taken is always optimal as nature is God’s creation, in men the goodness or badness of men’s actions is dependent on their state of wisdom, that is, how developed their understanding is. The more wise men are, the more metaphysical goodness or perfection follows from their actions. (shrink)

The article attempts to account for some conversational strategies for the thematic construction of discourse in a 30,000 word corpus of contemporary oral French. The sub-genre studied is that of the ‘memory-activation interview’, a speech situation, or ‘activity-type’ in which dialogues and meaning are co-constructed with the purpose of reviving memories. The general analytical framework is that of ‘interactional sociolinguistics’ as defined by Schiffrin, in which the more specific aspects of ratification, legitimization and modes of contribution are redefined and (...) diversified. Also central in the memory-activation process is the interviewer%'s role which, although not of a therapeutical nature is shown as being fully involved both at macro- and micro- levels. The article also tries to widen the range of the currently available tools for the analysis of speech seen as a thematic–rhematic process through the alternation of speech turns. The notion of thematic-discursive perimeter is introduced to account for thematic consistency. (shrink)

There are now various approaches to understand where and how in the brain consciousness arises from neural activity, none of which is universally accepted. Difficulties among these approaches are reviewed, and a missing ingredient is proposed here to help adjudicate between them, that of ''perspectivalness.'' In addition to a suitable temporal duration and information content of the relevant bound brain activity, this extra component is posited as being a further important ingredient for the creation of consciousness from neural activity. It (...) guides the development of what is termed the ''Central Representation,'' which is supposed to be present in all mammals and extended in humans to support self-consciousness as well as phenomenal consciousness. Experimental evidence and a theoretical framework for the existence of the central representation are presented, which relates the extra component to specific buffer working memory sites in the inferior parietal lobes, acting as attentional coordinators on the spatial maps making up the central representation. The article closes with a discussion of various open questions. (shrink)

Intradermal capsaicin in humans causes pain, primary hyperalgesia, and secondary mechanical hyperalgesia and allodynia. Parallel changes occur in the responses of primate spinothalamic tract cells and in rat behavior. Neurotransmitters that trigger secondary mechanical hyperalgesia and allodynia include excitatory amino acids and substance P. Secondary mechanical allodynia is actively maintained by central mechanisms. Our group has investigated mechanisms of central sensitization of nociceptive neurons by examining the responses to intradermal injection of capsaicin. These experiments are pertinent to issues (...) raised by coderre & katz (sect. 2). (shrink)

Animal research suggests that central serotonergic neurons are involved in behavioral suppression, particularly anxiety-related inhibition. The hypothesis linking decreased serotonin transmission to reduced anxiety as the mechanism in the anxiolytic activity of benzodiazepines conflicts with most clinical observations. Serotonin antagonists show no marked capacity to alleviate anxiety. On the other hand, clinical signs of reduced serotonergic transmission (low 5-HIAA levels in the cerebrospinal fluid) are frequently associated with aggressiveness, suicide attempts, and increased anxiety. The target article attempts to reconcile (...) such human and animal findings by investigating whether anxiety reduction or increased impulsivity is more Likely to account for animal behavioral changes associated with decreased serotonergic transmission. The effects of manipulating central serotonin in experimental anxiety paradigms in animals (punishment, extinction, novelty) are reviewed and compared with the effects of antianxiety drugs. Anxiety seems neither necessary nor sufficient to induce control by serotonergic neurons on behavior. Further evidence suggests that behavioral effects of anxiolytics thought to be mediated by decreases in anxiety are not caused by the ability of these drugs to reduce serotonin transmission. Blockade of serotonin transmission, especially at the level of the substantia nigra, results in a shift of behavior toward facilitation of responding. This behavioral shift is particularly marked when there is competition between acting and restraining response tendencies and when obstacles prevent the immediate attainment of an anticipated reward. It is proposed that serotonergic neurons are involved not only in behavioral arousal but also in enabling the organism to arrange or tolerate delay before acting. Decreases in serotonin transmission seem to be associated with the increased performance of behaviors that are usually suppressed, though not necessarily because of the alleviation of anxiety, which might contribute to the suppression. (shrink)

Polycomb group proteins are evolutionary conserved chromatin‐modifying complexes, essential for the regulation of developmental and cell‐identity genes. Polycomb‐mediated transcriptional regulation is provided by two multi‐protein complexes known as Polycomb repressive complex 1 (PRC1) and 2 (PRC2). Recent studies positioned PRC1 as a foremost executer of Polycomb‐mediated transcriptional control. Mammalian PRC1 complexes can form multiple sub‐complexes that vary in their core and accessory subunit composition, leading to fascinating and diverse transcriptional regulatory mechanisms employed by PRC1 complexes. These mechanisms include PRC1‐catalytic activity (...) toward monoubiquitination of histone H2AK119, a well‐established hallmark of PRC1 complexes, whose importance has been long debated. In this review, the central roles that PRC1‐catalytic activity plays in transcriptional repression are emphasized and the recent evidence supporting a role for PRC1 complexes in gene activation is discussed. (shrink)

BackgroundFunctional changes after spinal cord injury are related to changes in cortical plasticity. These changes can be measured with electroencephalography and has potential to be used as a clinical biomarker.MethodIn this longitudinal study participants underwent a total of 30 sessions of robotic-assisted gait training over a course of 6 weeks. The duration of each session was 30 min. Resting state EEG was recorded before and after 30-session rehabilitation therapy. To measure gait, we used the Walking Index for Spinal Cord Injury (...) Scale, 10-Meter- Walking Test, Timed-Up-and-Go, and 6-Min-Walking Test. Balance was measured using Berg Balance Scale.ResultsFifteen participants with incomplete SCI who had AIS C or D injuries based on American Spinal Cord Injury Association Impairment Scale classification were included in this study. Mean age was 35.7 years and the mean time since injury was 17.08 months. All participants showed clinical improvement with the rehabilitation program. EEG data revealed that high beta EEG activity in the central area had a negative correlation with gait and balance measured at baseline, in a way that greater high beta EEG power was related to worse clinical function at baseline. Moreover, improvement in gait and balance had negative correlations with the change in alpha/theta ratio in the parietal area.ConclusionIn SCI, functional impairment and subsequent improvement following rehabilitation therapy with RAGT correlated with the change in cortical activity measured by EEG. Our results suggest that EEG alpha/theta ratio may be a potential surrogate marker of functional improvement during rehabilitation. Future studies are necessary to improve and validate these findings as a neurophysiological biomarker for SCI rehabilitation. (shrink)

Transvertebral magnetic stimulation (TVMS) of the human lumbar spinal cord can evoke bilateral rhythmic leg movements, as in walking, supposedly through the activation of spinal locomotor neural circuitry. However, an appropriate stimulus intensity that can effectively drive the human spinal locomotor circuitry to evoke walking-like movements has not been determined. To address this issue, TVMS was delivered over an intervertebral space of the lumbar cord (L1–L3) at different stimulus intensities (10–70% of maximum stimulator output) in healthy human adults. In (...) a stimulus intensity-dependent manner, TVMS evoked two major patterns of rhythmic leg movements in which the left-right movement cycles were coordinated with different phase relationships: hopping-like movements, in which both legs moved in the same direction in phase, and walking-like movements, in which both legs moved alternatively in anti-phase; uncategorized movements were also observed which could not be categorized as either movement type. Even at the same stimulation site, the stimulus-evoked rhythmic movements changed from hopping-like movements to walking-like movements as stimulus intensity was increased. Different leg muscle activation patterns were engaged in the induction of the hopping- and walking-like movements. The magnitude of the evoked hopping- and walking-like movements was positively correlated with stimulus intensity. The human spinal neural circuitry required a higher intensity of magnetic stimulation to produce walking-like leg movements than to produce hopping-like movements. These results suggest that TVMS activates distinct neural modules in the human spinal cord to generate hopping- and walking-like movements. (shrink)