Hirschsprung disease and the multiple endocrine neoplasia type 2 syndromes are hereditary disorders related to the abnormal migration, proliferation or survival of neural crest cells and their derivatives. Hirschsprung disease is a frequent disorder of the enteric nervous system, resulting in intestinal obstruction. The multiple endocrine neoplasia type 2 syndromes predispose to cancers of neural crest derivatives. Both diseases are associated with heterozygous mutations in the RET proto‐oncogene. RET encodes a transmembrane receptor tyrosine kinase expressed in neural crest lineages and (...) whose ligand, glial‐cell‐line‐derived neurotrophic factor, has been very recently identified. In vitro expression studies demonstrate that while Hirschsprung disease mutations result in loss of function of the mutant RET tyrosine kinase, multiple endocrine neoplasia type 2 mutations lead to its constitutive activation. Thus, the two ‘faces’ of RET, gain of function and loss of function, each lead to a different syndrome, respectively: multiple endocrine neoplasia type 2, a cancer syndrome, or Hirschsprung disease, a developmental defect. (shrink)

Anita Chari revives the concept of reification from Marx and the Frankfurt School to spotlight the resistance to neoliberal capitalism now forming at the level of political economy and at the more sensate, experiential level of subjective transformation. Reading art by Oliver Ressler, Zanny Begg, Claire Fontaine, Jason Lazarus, and Mika Rottenberg, as well as the politics of Occupy Wall Street, Chari identifies practices through which artists and activists have challenged neoliberalism's social and political logics, exposing its inherent tensions and (...) contradictions. (shrink)

The development of sustainable agri-food systems requires not only new academic knowledge, but also concrete social and organizational change in practice. This article reflects on the action research process that supported and explored the learning process in an emerging agri-food value chain in the Berlin-Brandenburg region in eastern Germany. The action research study involved value chain actors, academic researchers, and process facilitators in a learning network. By framing the network’s learning and problem solving processes in concepts of organizational learning, lessons (...) were drawn for researchers and value chain developers. The results underline the importance of process facilitation in a learning value chain to create a social space, in which the actors in the value chain can interact and find a common basis for collaboration. In the learning process, facilitators used an iterative design to consistently align learning activities with the needs of practitioners to ensure practical relevance. To establish new practices and partnerships, value chain actors challenged existing routines and developed new ideas and visions, while at the same time improving established practices within their organizations and along the entire value chain. (shrink)

We demonstrate in this paper that the probabilities for sequential measurements have features very different from those of single-time measurements. First, they cannot be modelled by a classical stochastic process. Second, they are contextual, namely they depend strongly on the specific measurement scheme through which they are determined. We construct Positive-Operator-Valued measures (POVM) that provide such probabilities. For observables with continuous spectrum, the constructed POVMs depend strongly on the resolution of the measurement device, a conclusion that persists even if we (...) consider a quantum mechanical measurement device or the presence of an environment. We then examine the same issues in alternative interpretations of quantum theory. We first show that multi-time probabilities cannot be naturally defined in terms of a frequency operator. We next prove that local hidden variable theories cannot reproduce the predictions of quantum theory for sequential measurements, even when the degrees of freedom of the measuring apparatus are taken into account. Bohmian mechanics, however, does not fall in this category. We finally examine an alternative proposal that sequential measurements can be modeled by a process that does not satisfy the Kolmogorov axioms of probability. This removes contextuality without introducing non-locality, but implies that the empirical probabilities cannot be always defined (the event frequencies do not converge). We argue that the predictions of this hypothesis are not ruled out by existing experimental results (examining in particular the “which way” experiments); they are, however, distinguishable in principle. (shrink)

The Buddhist monk Upagupta, who preached and taught meditative practices in Northwest India over two thousand years ago, is venerated today by the laity in ...

Two initiatives in community-based biodiversity conservation are examined. I describe key aspects of the formation in the mid 1990s of the Malpai Borderlands Group of the Southwest US, and the reorganisation of the Kenya Wildlife Service during 1994–6 and their legacies since then. I review how history, ownership, membership, and valuation were appealed to, created, maintained, and contested in defining what should be saved, by and for whom, and how in each. I also suggest the central role of science and (...) relatively mundane technologies in co-ordinating these parameters. Success or 'best practice' as applied to the conjunction of biodiversity conservation and development depends upon this work in contesting and establishing history, ownership, membership and valuation. (shrink)

The rapid economic growth and surge of consumerism in emerging markets have placed significant pressure on the environment and consumers. While well-researched ethical consumption remedies may be effective in the Western contexts, they may not be readily translatable in emerging markets due to institutional and socio-cultural differences. This research examines the popular practice of Danshari in China and investigates how this self-oriented practice leads to other-oriented ethical consumption behaviours. Using qualitative data gathered from online sharing and interviews, we unpack how (...) Danshari practitioners question and reshape their relationship with possessions and consumption to enhance their self-concept clarity. This clarified and elevated self-concept, in turn, leads to ethical consumption behaviours. Unlike Western ethical consumption concepts that are driven by principles or ideologies, Danshari’s essence of detachment, self-orientation, and action focus resonate with traditional Chinese teachings, providing a pragmatist approach to cultivating ethical consumption behaviours in China. This research adds to the growing body of pragmatism-based ethics research, expands the discussion of the link between consumption and the self, and offers valuable insights into promoting ethical consumerism in emerging markets. (shrink)

'Particle or Wave' explains the origins and development of modern physical concepts about matter and the controversies surrounding them.

The idea that mind and body are distinct entities that interact is often claimed to be incompatible with physics. The aim of this paper is to disprove this claim. To this end, we construct a broad mathematical framework that describes theories with mind-body interaction (MBI) as an extension of current physical theories. We employ histories theory, i.e., a formulation of physical theories in which a physical system is described in terms of (i) a set of propositions about possible evolutions of (...) the system and (ii) a probability assignment to such propositions. The notion of dynamics is incorporated into the probability rule. As this formulation emphasises logical and probabilistic concepts, it is ontologically neutral. It can be used to describe mental `degrees of freedom' in addition to physical ones. This results into a mathematical framework for psycho-physical interaction (ΨΦI formalism). Interestingly, a class of ΨΦI theories turns out to be compatible with energy conservation. (shrink)

The idea that mind and body are distinct entities that interact is often claimed to be incompatible with physics. The aim of this paper is to disprove this claim. To this end, we construct a broad mathematical framework that describes theories with mind–body interaction (MBI) as an extension of current physical theories. We employ histories theory, i.e., a formulation of physical theories in which a physical system is described in terms of (i) a set of propositions about possible evolutions of (...) the system and (ii) a probability assignment to such propositions. The notion of dynamics is incorporated into the probability rule. As this formulation emphasises logical and probabilistic concepts, it is ontologically neutral. It can be used to describe mental ‘degrees of freedom’ in addition to physical ones. This results into a mathematical framework for psycho-physical interaction (ΨΦ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\Psi \Phi$$\end{document}I formalism). Interestingly, a class of ΨΦ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\Psi \Phi$$\end{document}I theories turns out to be compatible with energy conservation. (shrink)

The aim of this paper is to offer a concise and faithful account of Rawls’ theory of international justice, in an effort, first, to elucidate the structure of the argument that is advanced in that theory and, second, to present a critical assessment of it. The critical assessment section attempts, on the one side, to cope with crucial methodological issues, which have a more general bearing upon Rawls’ overall political philosophical position, including the constructivist perspective of theory making and the (...) division between a political conception and a comprehensive doctrine; on the other side, to weigh up a set of substantive claims made in the Rawlsian theory of international justice, including the recognition of peoples as the fundamental subjects of international law, the toleration of the so-called decent peoples and the considerably thin construal of human rights encompassed in The Law of Peoples. The paper attempts to provide a series of reasons that could be well-suited to explicate its author’s doubts about the soundness of the Rawlsian theoretical perspective with regard to both its formal methodological features and its more content-oriented convictions. (shrink)

Volume 10, Issue 1, March 2019, Page 77-84.

This is a textbook on quantum mechanics. It is addressed to graduates and advanced undergraduates. The book presents quantum theory as a logically coherent system, placing stronger emphasis on the theory' s probabilistic structure and on the role of symmetries. It makes students aware of foundational problems from the very beginning, but at the same time, it urges them to adopt a pragmatic attitude towards the quantum formalism. The book consists of five parts. Part I is a review of classical (...) physics, including probability theory, and a historical introduction to quantum theory. Part II presents quantum theory in terms of six fundamental principles. The principles are presented together with the necessary mathematical background and with applications to simple systems. Part III analyses the properties of quantum particles. It starts with the description of symmetries, continues to non-relativistic particles, the introduction of spin, and particle statistics. It concludes with a symmetries-based introduction to relativistic quantum systems and with the first steps towards relativistic quantum field theory. Part IV presents techniques adapted to specific problems: the structure and spectra of composite systems, decays and transitions, particle scattering, and open quantum systems. Finally, Part V revisits quantum foundations: quantum measurement theory, the major interpretations of quantum theory, and the frontiers of quantum theory in contemporary research. (shrink)

I introduce the concept of ‘fused descriptive and normative proposition.’ I demonstrate that and how this concept has a basis in reality in lawyers' propositions de lege lata, and I point out that and why we do not find fused modality in language qua language, morals and the relationship between parents and children. The concept of ‘fused descriptive and normative proposition’ is of interest in a number of contexts, inter alia in relation to law, cf. the debate about the status (...) of lawyers' propositions de lege lata (“exactly what kind of propositions are lawyers' propositions about what is the law?”), and in relation to philosophy, cf. the debate about the relationship between ‘the is‘ and ‘the ought.’ As a consequence of the reality basis and interest of this concept, I see the concepts of ‘descriptive proposition’ and ‘normative proposition’ as the extreme points on a graduated dimension, from the purely descriptive to the purely normative. (shrink)

The paper deals with the notion of guilt according to Heidegger’s philosophy and its repercussions for the understanding of guilt according to criminal law doctrine and theory. Heidegger’s notion on guilt is tantamount to Dasein’s incapacity to exhaust all its existential possibilities, whereas legal guilt has to do only with man’s legal indebtedness, which is an aspect of inauthenticity, a deficient mode of ontological responsibility. This does not mean, though, sheer amoralism or apologetics to violence. In late Heidegger one may (...) discern traces of an ontological ethics, which refers to Dasein’s attunement to Being and especially to the sparing and healing of the Fourfold as these are coming to presence through poetic dwelling; through, that is, an authentic contact with the Uncanny, meaning a radical exposure to Being’s enigmatic hiddenness, the endurance in front of the abyss of Nothingness. In this framework there remains no space for assuming any moral-juridical responsibility, because Dasein is predestined to err constantly due to the ruptures and turnings of Being’s history. Legal blameworthiness is thus obsolete because, injustice being according to Heidegger the dis-jointure of Being’s order, there is ontologically no imputable ‘legal’ crime; there is only Dasein’s eventful projecting-opening within errancy. Whether though this notion of ‘Being’ is a new ‘arche’ to be superseded emerges then as the crucial question. To regain any non-metaphysical notion of guilt is after Heidegger only possible through a theoretical move which cannot ignore his legacy but also has to go beyond the Master. (shrink)

Transversality occupies a central place in Guattari's thought, appearing in his early writings on institutional analysis and on through to his final work, Chaosmosis. Transversality is thus particularly pertinent to understanding Guattari's critique of semiocapitalism and his goal of re-imagining forms of institutional subjectivisation as a way to free the unconscious from structures of lack and the desire for punishment, the very structures upon which capitalism relies for its reproduction. If there is one institution that has taken advantage of semiocapitalism's (...) ability to mask its role in the reproduction of capitalist subjectivity, however, it is the contemporary neoliberal University. This essay thus brings transversality to bear upon the question of the University in semiocapitalism, focusing on the discourses that speak in defence of the humanities. Though defences of the humanities are intended to argue for the humanities’ usefulness in contemporary society, transversality exposes such discourses as the speech of a ‘subjugated group’ whose only effect is to reinforce existing structures of lack and punishment. (shrink)

In A Theory of Justice (1971), John Rawls introduces the concept of “reflective equilibrium.” Although there are innumerable references to and discussions of this concept in the literature, there is, to the present author's knowledge, no discussion of the most important question: Why reflective equilibrium? In particular, the question arises: Is the method of reflective equilibrium applicable to the choice of this method itself? Rawls's drawing of parallels between Kant's moral theory and his own suggests that his concept of “reflective (...) equilibrium” is on a par with Kant's concept of “transcendental deduction.” Treating these two approaches to justification as paradigmatic, I consider their respective merits in meeting the reflexive challenge, i.e., in offering a justification for choice of mode of justification. My enquiry into this topic comprises three parts. In the first part (Eng 2014a), I raised the issue of the reflexivity of justification and questioned whether the reflexive challenge can be met within the framework of A Theory of Justice. In this second part, I shall outline a Kantian approach that represents a paradigmatic alternative to Rawls. (shrink)

In A Theory of Justice (1971), John Rawls introduces the concept of “reflective equilibrium.” Although there are innumerable references to and discussions of this concept in the literature, there is, to the present author's knowledge, no discussion of the most important question: Why reflective equilibrium? In particular, the question arises: Is the method of reflective equilibrium applicable to the choice of this method itself? Rawls's drawing of parallels between Kant's moral theory and his own suggests that his concept of “reflective (...) equilibrium” is on a par with Kant's concept of “transcendental deduction.” Treating these two approaches to justification as paradigmatic, I consider their respective merits in meeting the reflexive challenge, i.e., in offering a justification for choice of mode of justification. In the first part of this enquiry (Eng 2014a), I raised the issue of the reflexivity of justification and questioned whether the reflexive challenge can be met within the framework of A Theory of Justice. In the second part (Eng 2014b), I outlined a Kantian approach that represents a paradigmatic alternative to Rawls. In this third and final part, I shall argue that Rawls's reflective equilibrium cannot justify the choice of itself and that in the broader perspective thus necessitated, we cannot escape the metaphysical issues integral to the Kantian approach. (shrink)

The word _meṇḍaka_, a derivative of _meṇḍa_ (“ram”), is generally translated as “made of the ram” or “about the ram” or “horned.” However, in the Pāli _Milindapañha_ (_Questions of Milinda_), the word _meṇḍakapañha_, literally, a question about the ram, is also rendered as a logical conclusion that refutes an imaginary dilemma. Hence, in this treatise, the word _meṇḍaka_ is a special logical term which means an imaginary dilemma that can be logically refuted. This raises the question as to why the (...) word _meṇḍaka_ has come to be associated with this logical technique. To answer this question, this paper examines various aspects of the word and its possible connections to a dilemma and its refutation. The discussion ranges from the meaning of this word in a tale in the _Jātaka_ (Birth Stories), within the contextual usage in a _meṇḍaka_ question, to a relatively recent commentarial text (_aṭṭhakathā_) which gives a different perspective on the etymology of the word. The _Milindapañha_ is explicit in defining a _meṇḍaka_ question as knotty, hard to penetrate, and difficult to resolve, some of which an opponent puts forth to undermine certain aspects of the Buddhist system. However, the way certain _meṇḍaka_ questions are framed, though not directly stated, seem to utilize the principles of logic in a dilemmatic form of argument. With that, a _meṇḍaka_ question, at least in the _Milindapañha_, could also mean “a dilemmatic expression put forth by a challenger to undermine an opponent, but which can be logically refuted.”. (shrink)

This article re-examines speculations about school affiliation of the Milindapañha (Questions of King Milinda) and traces its presence from North West India in the early centuries CE up to Southeast Asia in the nineteenth century. As there are significant differences between the textual traditions of the Pali Text Society’s Milindapañho and the Siamese printed edition, the Milindapañh?, I will discuss the little-known textual characteristics of the Siamese recensions which were circulating in Central Siam from at least the seventeenth century. This (...) is possible with the discovery of several Ayutthaya period Milindapañha manuscripts kept at a temple and the National Library of Thailand. By the end of the eighteenth century, at least three different recensions were circulating in Central Siam. This paper will present some of their dissimilarities as well as their probable textual lineages. The newly discovered manuscripts also partly demonstrate that the shape of the textual tradition of a text, at least for the Milindapañha in Siam, reflects a function of the textual community that preserved and transmitted it. (shrink)

This article engages Axel Honneth’s recent work on Georg Lukács’ concept of reification in order to formulate a politically relevant and historically specific critique of capitalism that is applicable to theorizing contemporary democratic practice. I argue that Honneth’s attempt to reorient the critique of reification within the terms of a theory of recognition has done so at the cost of sacrificing the core of the concept, which forged a connection between the socio-political analysis of capitalist domination and an analysis of (...) the unengaged, spectatorial stance of human beings toward the world, showing how they together impede emancipatory social transformation. In order to accomplish the unfinished task of rendering the critique of reification applicable to contemporary critical theory, I seek to synthesize the advantages of Honneth’s approach, which focuses on the normative aspects of the critique of reification, with Lukács’ emphasis on the practical, political-economic dimensions of reification and the historically specific pathologies of the capitalist social form. (shrink)

. In this reply to Dahlman, the focus is on aspects that I take to be of general interest. The point to be emphasised is the absence of a critically reflexive mode of questioning on the part of Dahlman and, in general, on the part of the position he represents, namely, an empiricist and logical paradigm of atemporal cognition and control. It is argued that lawyers’ thinking de lege lata—with its distinctive connection to normativity and morals, through the unity of (...) the temporal and institutional dimensions in fused modality—can never be understood within such a framework. (shrink)

According to the received opinion there is a theoretical incompatibility between Herbert Hart'sThe Concept of Lawand Alf Ross'sOn Law and Justice, and, according to the received opinion, it stems above all from Hart's emphasis on the internal point of view. The present paper argues that this reading is mistaken.The Concept of Lawdoes not go beyondOn Law and Justicein so far as both present arguments to the effect that law is based on a shared understanding between participants in a project perceived (...) by every participant to be a project in common. The paper demonstrates that there are substantive parallels between Hart's combination of “acceptance” or “acknowledgement” and a “critical reflective attitude” and Ross's combination of “motivation” or “feeling” and a “coherent whole of meaning and motivation.” The main conclusion is that the views of norms and normativity put forward inThe Concept of LawandOn Law and Justiceare very close in essential respects, and, more specifically, that the two works are at root identical in their representation of the basis of normativity in reality. (shrink)