Recent studies have indicated that it is possible to protect individuals from HIV infection using passive infusion of monoclonal antibodies. However, in order for monoclonal antibodies to confer robust protection, the antibodies must be capable of neutralizing many possible strains of the virus. This is particularly challenging in the context of a highly diverse pathogen like HIV. It is therefore of great interest to leverage existing observational data sources to discover antibodies that are able to neutralize HIV viruses via residues (...) where existing antibodies show modest protection. Such information feeds directly into the clinical trial pipeline for monoclonal antibody therapies by providing information on whether and to what extent combinations of antibodies can generate superior protection and strategies for analyzing past clinical trials to identify in vivo evidence of antibody resistance. These observational data include genetic features of many diverse HIV genetic sequences, as well as in vitro measures of antibody resistance. The statistical learning problem we are interested in is developing statistical methodology that can be used to analyze these data to identify important genetic features that are significantly associated with antibody resistance. This is a challenging problem owing to the high-dimensional and strongly correlated nature of the genetic sequence data. To overcome these challenges, we propose an outcome-adaptive, collaborative targeted minimum loss-based estimation approach using random forests. We demonstrate via simulation that the approach enjoys important statistical benefits over existing approaches in terms of bias, mean squared error, and type I error. We apply the approach to the Compile, Analyze, and Tally Nab Panels database to identify AA positions that are potentially causally related to resistance to neutralization by several different antibodies. (shrink)

Understanding the pathways whereby an intervention has an effect on an outcome is a common scientific goal. A rich body of literature provides various decompositions of the total intervention effect into pathway-specific effects. Interventional direct and indirect effects provide one such decomposition. Existing estimators of these effects are based on parametric models with confidence interval estimation facilitated via the nonparametric bootstrap. We provide theory that allows for more flexible, possibly machine learning-based, estimation techniques to be considered. In particular, we establish (...) weak convergence results that facilitate the construction of closed-form confidence intervals and hypothesis tests and prove multiple robustness properties of the proposed estimators. Simulations show that inference based on large-sample theory has adequate small-sample performance. Our work thus provides a means of leveraging modern statistical learning techniques in estimation of interventional mediation effects. (shrink)

This book is a systematic and constructive treatment of a number of traditional issues at the foundation of ethics, the possibility and nature of moral knowledge, the relationship between the moral point of view and a scientific or naturalistic world view, the nature of moral value and obligation, and the role of morality in a person's rational life plan. In striking contrast to many traditional authors and to other recent writers in the field, David Brink offers an integrated defense (...) of the objectivity of ethics. (shrink)

David McNeill, a pioneer in the ongoing study of the relationship between gesture and language, here argues that gestures are active participants in both speaking and thinking. He posits that gestures are key ingredients in an “imagery-language dialectic” that fuels speech and thought. The smallest unit of this dialectic is the growth point, a snapshot of an utterance at its beginning psychological stage. In _Gesture and Thought,_ the central growth point comes from a Tweety Bird cartoon. Over the course (...) of twenty-five years, the McNeill Lab showed this cartoon to numerous subjects who spoke a variety of languages, and a fascinating pattern emerged. The shape and timing of gestures depends not only on what speakers see but on what they take to be distinctive; this, in turn, depends on the context. Those who remembered the same context saw the same distinctions and used similar gestures; those who forgot the context understood something different and changed gestures or used none at all. Thus, the gesture becomes part of the growth point—the building block of language and thought. _Gesture and Thought _is an ambitious project in the ongoing study of how we communicate and how language is connected to thought. (shrink)

David Boonin has written the most thorough and detailed case for the moral permissibility of abortion yet published. Critically examining a wide range of arguments that attempt to prove that every human fetus has a right to life, he shows that each of these arguments fails on its own terms. He then explains how even if the fetus does have a right to life, abortion can still be shown to be morally permissible on the critique of abortion's own terms. (...) Finally he considers several pro-life arguments that do not depend on claims that the fetus has a right to life and concludes that these too are ultimately unsuccessful. This major book will be especially helpful to those teaching applied ethics and bioethics in philosophy departments or professional schools of law and medicine. It will interest students of women studies and general readers for whom abortion remains a high-profile issue. (shrink)

Poverty, inequality, violence, environmental degradation, and tyranny continue to afflict the world. Ethics of Global Development offers a moral reflection on the ends and means of local, national, and global efforts to overcome these five scourges. After emphasizing the role of ethics in development studies, policy-making, and practice, David A. Crocker analyzes and evaluates Amartya Sen's philosophy of development in relation to alternative ethical outlooks. He argues that Sen's turn to robust ideals of human agency and democracy improves on (...) both Sen's earlier emphasis on 'capabilities and functionings' and Martha Nussbaum's version of the capability orientation. This agency-focused capability approach is then extended and strengthened by applying it to the challenges of consumerism and hunger, the development responsibilities of affluent individuals and nations, and the dilemmas of globalization. Throughout the book the author argues for the importance of more inclusive and deliberative democratic institutions. (shrink)

In the _The Undivided Universe_, David Bohn and Basil Hiley present a radically different approach to quantum theory. They develop an interpretation of quantum mechanics which gives a clear, intuitive understanding of its meaning and in which there is a coherent notion of the reality of the universe without assuming a fundamental role for the human observer. With the aid of new concepts such as active information together with non-locality, they provide a comprehensive account of all the basic features (...) of quantum mechanics, including the relativistic domain and quantum field theory. It is shown that, with the new approach, paradoxical or unsatisfactory features associated with the standard approaches, such as the wave-particle duality and the collapse of the wave function, do not arise. Finally, the authors make new suggestions and indicate some areas in which one may expect quantum theory to break down in a way that will allow for a test. _The Undivided Universe_ is an important book especially because it provides a different overall world view which is neither mechanistic nor reductionist. This view will ultimately have radical implications not only in physics but also in our general approach to all areas of life. (shrink)

In this classic, David Bohm was the first to offer us his causal interpretation of the quantum theory. _Causality and Chance in Modern Physics_ continues to make possible further insight into the meaning of the quantum theory and to suggest ways of extending the theory into new directions.

Whether children have rights is a debate that in recent years has spilled over into all areas of public life. It has never been more topical than now as the assumed rights of parents over their children is challenged on an almost daily basis. David Archard offers the first serious and sustained philosophical examination of children and their rights. Archard reviews arguments for and against according children rights. He concludes that every child has at least the right to the (...) best possible upbringing. Denying that parents have any significant rights over their children, he is able to challenge current thinking about the proper roles of state and family in rearing children. Crucially, he considers the problem of how to define and understand `child abuse'. (shrink)

This book uncovers the lost history of Christianity's encounters with Pythagorean ideas before the Renaissance. David Albertson skillfully examines ancient and medieval theologians, particularly Thierry of Chartres and Nicholas of Cusa, who successfully reconceived the Trinity and the Incarnation within the framework of Greek number theory. David Albertson challenges modern assumptions about the complex relationship between religion and science.

Plato's Theaetetus is an acknowledged masterpiece, and among the most influential texts in the history of epistemology. Since antiquity it has been debated whether this dialogue was written by Plato to support his familiar metaphysical doctrines, or represents a self-distancing from these. David Sedley's book offers a via media, founded on a radical separation of the author, Plato, from his main speaker, Socrates. The dialogue, it is argued, is addressed to readers familiar with Plato's mature doctrines, and sets out (...) to show how these doctrines, far from being an abandonment of his Socratic heritage, are its natural outcome. The Socrates portrayed here is the same Socrates as already portrayed in Plato's early dialogues. While not a Platonist, he is exhibited - to put it in terms of an image made famous by this dialogue - as having been Platonism's midwife. In a comprehensive rereading of the text, Sedley tracks the ways in which Socrates is shown unwittingly preparing the ground for Plato's mature doctrines, and reinterprets the dialogue's individual arguments from this perspective. The book is addressed to all readers interested in Plato, and does not require knowledge of Greek. (shrink)

David Wiggins; II*—Deliberation and Practical Reason, Proceedings of the Aristotelian Society, Volume 76, Issue 1, 1 June 1976, Pages 29–52, https://doi.org/10.

One way to understand science is as a selection process. David Hull, one of the dominant figures in contemporary philosophy of science, sets out in this 2001 volume a general analysis of this selection process that applies equally to biological evolution, the reaction of the immune system to antigens, operant learning, and social and conceptual change in science. Hull aims to distinguish between those characteristics that are contingent features of selection and those that are essential. Science and Selection brings (...) together many of David Hull's most important essays on selection in one accessible volume. (shrink)

Clearly and engagingly written, this volume is vital reading for students of philosophy and sociology, and anyone interested in Wittgenstein's later thought. David Bloor provides a challenging and informative evaluation of Wittgenstein's account of rules and rule-following. Arguing for a collectivist reading, Bloor offers the first consistent sociological interpretation of Wittgenstein's work for many years.

Evidence suggests that psychedelics bring about their therapeutic outcomes in part through the subjective or qualitative effects they engender and how the individual interprets the resulting experiences. However, psychedelics are contraindicated for individuals who have been diagnosed with certain mental illnesses, on the grounds that these subjective effects may be disturbing or otherwise counter-therapeutic. Substantial resources are therefore currently being devoted to creating psychedelic substances that produce many of the same biological changes as psychedelics, but without their characteristic subjective effects. (...) In this article, we consider ethical issues arising from the prospect of such potential “nonsubjective” psychedelics. We are broadly supportive of efforts to produce such substances for both scientific and clinical reasons. However, we argue that such nonsubjective psychedelics should be reserved for those special cases in which the subjective effects of psychedelics are specifically contraindicated, whereas classic psychedelics that affect subjective experience should be considered the default and standard of care. After reviewing evidence regarding the subjective effects of psychedelics, we raise a number of ethical concerns around the prospect of withholding such typically positive, meaningful, and therapeutic experiences from most patients. (shrink)

It is a challenge to explain how evolutionary altruism can evolve by the process of natural selection, since altruists in a group will be less fit than the selfish individuals in the same group who receive benefits but do not make donations of their own. Darwin proposed a theory of group selection to solve this puzzle. Very simply, even though altruists are less fit than selfish individuals within any single group, groups of altruists are more fit than groups of selfish (...) individuals. If a population is subdivided into many groups that vary in their altruistic tendencies, altruism will be favored at the level of selection among groups even as it is being disfavored at the level of selection among individuals within groups. Darwin’s scenario became the basis for a theoretical framework called multilevel selection theory. (shrink)

In _The Formation of Reason_, philosophy professor David Bakhurst utilizes ideas from philosopher John McDowell to develop and defend a socio-historical account of the human mind. Provides the first detailed examination of the relevance of John McDowell's work to the Philosophy of Education Draws on a wide-range of philosophical sources, including the work of 'analytic' philosophers Donald Davidson, Ian Hacking, Peter Strawson, David Wiggins, and Ludwig Wittgenstein Considers non-traditional ideas from Russian philosophy and psychology, represented by Ilyenkov and (...) Vygotsky Discusses foundational philosophical ideas in a way that reveals their relevance to educational theory and practice. (shrink)

A landmark work of western philosophy, "On the Genealogy of Morality" is a dazzling and brilliantly incisive attack on European "morality". Combining philosophical acuity with psychological insight in prose of remarkable rhetorical power, Nietzsche takes up the task of offering us reasons to engage in a re-evaluation of our values. In this book, David Owen offers a reflective and insightful analysis of Nietzsche's text. He provides an account of how Nietzsche comes to the project of the re-evaluation of values; (...) he shows how the development of Nietzsche's understanding of the requirements of this project lead him to acknowledge the need for the kind of investigation of "morality" that he terms "genealogy"; he elucidates the general structure and substantive arguments of Nietzsche's text, accounting for the rhetorical form of these arguments, and he debates the character of genealogy as a form of critical enquiry. Owen argues that there is a specific development of Nietzsche's work from his earlier "Daybreak" and that in "Genealogy of Morality", Nietzsche is developing a critique of modes of agency and that this constitutes the most fundamental aspect of his demand for a revaluation of values. The book is a distinctive and significant contribution to our understanding of Nietzsche's great text. (shrink)

David Gauthier is one of the most outstanding and influential philosophers working in moral theory today, and his book Morals by Agreement has established him as a preeminent defender of contractarian moral theory. This volume brings together a selection of his best essays on contractarianism, many of which have become difficult to find.

The bulk of this volume consists of a somewhat revised version of the Axel Hägerström Lectures given in Uppsala, Sweden in 1991. It also contains previously published papers on the relevance of philosophy of language to ethics and the interpretation of Kant’s moral philosophy. The latter, in particular, deserves comment, but space considerations force me to devote my attention to the Hägerström Lectures, entitled “A Taxonomy of Ethical Theories.”.

One of the foremost scientists and thinkers of our time, David Bohm worked alongside Oppenheimer and Einstein. In _Science, Order and Creativity_ he and physicist F. David Peat propose a return to greater creativity and communication in the sciences. They ask for a renewed emphasis on ideas rather than formulae, on the whole rather than fragments, and on meaning rather than mere mechanics. Tracing the history of science from Aristotle to Einstein, from the Pythagorean theorem to quantum mechanics, (...) the authors offer intriguing new insights into how scientific theories come into being, how to eliminate blocks to creativity and how science can lead to a deeper understanding of society, the human condition and the human mind itself. _Science, Order and Creativity_ looks to the future of science with elegance, hope and enthusiasm. (shrink)

In an important departure from theories of causation, David Owens proposes that coincidences have no causes, and that a cause is something which ensures that its effects are no coincidence. In Causes and Coincidences, he elucidates the idea of a coincidence as an event which can be analysed into constituent events, the nomological antecedents of which are independent of each other. He also suggests that causal facts can be analysed in terms of non-causal facts, including relations of necessity. Thus, (...) causation is defined in terms of coincidence, and coincidence without reference to causation. David Owens challenges the ideas associated with Hume, Davidson and Lewis, constructing a theory which distinguishes nomological necessity and sufficiency from their logical counterparts. He is able to offer novel solutions to the major problems of causation, including the direction of causation, the logical form of causal statements, the distinction betwen causal connections and logical connections, and the relationship between psychological and physical causation. (shrink)

The resemblance theory of representation is the view that one thing represents another by virtue of resembling it. Typically, it is taken as non-controversial that Berkeley accepts the resemblance theory of representation – even if the plausibility of the resemblance theory itself comes under scrutiny. One piece of evidence in favour of this reading of Berkeley is his commitment to the ‘likeness principle’: the view that ‘an idea can be like nothing but an idea’ (PHK § 8). The likeness principle (...) is typically seen as a rejection of the kind of indirect theory of perception that is often attributed to Locke. However, by paying particular attention to Berkeley’s account of how mental representation via the imagination works, Dávid Bartha casts doubt on the consensus view that Berkeley does accept the resemblance theory of representation. (shrink)

As neurotechnologies continue to develop and diffuse, this fast-paced field must be guided by robust governance frameworks in order to promote responsible innovation. The article by Bublitz (2024)...

"Daimon Life is life-enchancing. To read it is to become richer in word." –John Llewelyn Disclosure of Martin Heidegger’s complicity with the National Socialist regime in 1933-34 has provoked virulent debate about the relationship between his politics and his philosophy. Did Heidegger’s philosophy exhibit a kind of organicism readily transformed into ideological "blood and soil"? Or, rather, did his support of the Nazis betray a fundamental lack of loyalty to living things? David Farrell Krell traces Heidegger’s political authoritarianism to (...) his failure to develop a constructive "life-philosophy"—his phobic reactions to other forms of being. Krell details Heidegger’s opposition to Lebensphilosophie as expressed in Being and Time, in an important but little-known lecture course on theoretical biology given in 1929–30 called "The Basic Concepts of Metaphysics," and in a recently published key text, Contributions to Philosophy, written in 1936–38. Although Heidegger’s attempt to think through the problems of life, sexual reproduction, behavior, environment, and the ecosystem ultimately failed, Krell contends that his methods of thinking nonetheless pose important tasks for our own thought. Drawing on and away from Heidegger, Krell expands on the topics of life, death, sexuality, and spirit as these are treated by Freud, Nietzsche, Derrida, and Irigaray. Daimon Life addresses issues central to contemporary philosophies of politics, gender, ecology, and theoretical biology. (shrink)

In his quest to solve 'the ever-disquieting riddle of existence', Schopenhauer explored almost every dimension of human existence, developing a darkly compelling worldview that found deep resonance in contemporary literature, music, philosophy, and psychology. This is the first comprehensive biography of Schopenhauer written in English. Placing him in his historical and philosophical contexts, David E. Cartwright tells the story of Schopenhauer's life to convey the full range of his philosophy. He offers a fully documented portrait in which he explores (...) Schopenhauer's fractured family life, his early formative influences, his critical loyalty to Kant, his personal interactions with Fichte and Goethe, his ambivalent relationship with Schelling, his contempt for Hegel, his struggle to make his philosophy known, and his reaction to his late-arriving fame. (shrink)

When patients are admitted to the hospital, they are generally expected to remain in or within close proximity to their assigned rooms in order to promote their safety and appropriate medical care. Although there are circumstances when patients may safely leave their hospital room or floor, guidance within the medical literature for the management of patient movement within the hospital are lacking. Excessive restrictions on patient movement may be seen as overly paternalistic, while lax requirements may interfere with high quality (...) care, patient safety and efficient hospital practice. As a result, guidance in the form of institutional policy is warranted. Such policy development should take into consideration the potential clinical, legal, and ethical concerns in balancing the competing values of patients’ preferences and respect for autonomy, while ensuring high quality, safe, and efficacious medical care. This paper will provide a framework for hospitals to create institution-specific patient movement policies that are fair, systematic, and transparent. (shrink)

_A powerful treatise that demonstrates the existence of altruism in nature, with surprising implications for human society_ Does altruism exist? Or is human nature entirely selfish? In this eloquent and accessible book, famed biologist David Sloan Wilson provides new answers to this age-old question based on the latest developments in evolutionary science. From an evolutionary viewpoint, Wilson argues, altruism is inextricably linked to the functional organization of groups. “Groups that work” undeniably exist in nature and human society, although special (...) conditions are required for their evolution. Humans are one of the most groupish species on earth, in some ways comparable to social insect colonies and multi-cellular organisms. The case that altruism evolves in all social species is surprisingly simple to make. Yet the implications for human society are far from obvious. Some of the most venerable criteria for defining altruism aren’t worth caring much about, any more than we care much whether we are paid by cash or check. Altruism defined in terms of thoughts and feelings is notably absent from religion, even though altruism defined in terms of action is notably present. The economic case for selfishness can be decisively rejected. The quality of everyday life depends critically on people who overtly care about the welfare of others. Yet, like any other adaptation, altruism can have pathological manifestations. Wilson concludes by showing how a social theory that goes beyond altruism by focusing on group function can help to improve the human condition. (shrink)

_A powerful treatise that demonstrates the existence of altruism in nature, with surprising implications for human society_ Does altruism exist? Or is human nature entirely selfish? In this eloquent and accessible book, famed biologist David Sloan Wilson provides new answers to this age-old question based on the latest developments in evolutionary science. From an evolutionary viewpoint, Wilson argues, altruism is inextricably linked to the functional organization of groups. “Groups that work” undeniably exist in nature and human society, although special (...) conditions are required for their evolution. Humans are one of the most groupish species on earth, in some ways comparable to social insect colonies and multi-cellular organisms. The case that altruism evolves in all social species is surprisingly simple to make. Yet the implications for human society are far from obvious. Some of the most venerable criteria for defining altruism aren’t worth caring much about, any more than we care much whether we are paid by cash or check. Altruism defined in terms of thoughts and feelings is notably absent from religion, even though altruism defined in terms of action is notably present. The economic case for selfishness can be decisively rejected. The quality of everyday life depends critically on people who overtly care about the welfare of others. Yet, like any other adaptation, altruism can have pathological manifestations. Wilson concludes by showing how a social theory that goes beyond altruism by focusing on group function can help to improve the human condition. (shrink)

In Philosophy and International Law, David Lefkowitz examines core questions of legal and political philosophy through critical reflection on contemporary international law. Is international law really law? The answer depends on what makes law. Does the existence of law depend on coercive enforcement? Or institutions such as courts? Or fidelity to the requirements of the rule of law? Or conformity to moral standards? Answers to these questions are essential for determining the truth or falsity of international legal skepticism, and (...) understanding why it matters. Is international law morally defensible? This book makes a start to answering that question by engaging with recent debates on the nature and grounds of human rights, the moral justifiability of the law of war, the concept of a crime against humanity, the moral basis of universal jurisdiction, the propriety of international law governing secession, and the justice of international trade law. (shrink)

Dan Korman and Dustin Locke argue that non-naturalists are rationally committed to withhold moral belief. A main principle in their argument, which they call EC*, can be read in either of two ways, which I call EC*-narrow and EC*-wide. I show that EC*-narrow is implausible. Then I show that, if Korman and Locke rely on EC*-wide to critique non-naturalism, then the critique fails. I explain how the availability of a view that I like to call moral occasionalism can be used (...) to respond on the non-naturalist’s behalf to the EC*-wide version of the argument. I also show how moral occasionalism is more useful for this purpose than an alternative third-factor account, namely David Enoch’s pre-established harmony view. (shrink)

David Miller explores and develops Michael Walzer's notion of complex equality as a way of bringing together the potentially conflicting ideas of distributive justice and social equality. He examines the empirical plausibility of the notion of complex equality and argues that Walzer's theory of the spheres of justice allows the construction of an understanding of distributive justice and social equality that is different from, and superior to, mainstream political philosophy.

The paper takes off from the problem of finding a proper content for the relation of identity as it holds or fails to hold among ordinary things or substances. The necessary conditions of identity are familiar, the sufficient conditions less so. The search is for conditions at once better usable than the Leibnizian Identity of Indiscernibles (independently suspect) and strong enough to underwrite all the formal properties of the relation.It is contended that the key to this problem rests at the (...) level of metaphysics and epistemology alike with a sortalist position. Sortalism is the position which insists that, if the question is whether a and b are the same, it has to be asked what are they? Any sufficiently specific answer to that question will bring with it a principle of activity or functioning and a mode of behaviour characteristic of some particular kind of thing by reference to which questions of persistence or non-persistence through change can be adjudicated.These contentions are illustrated by reference to familiar examples such as the human zygote, the Ship of Theseus and Shoemaker's Brown-Brownson. The first example is hostage for a mass of unproblematical cases. The problems presented by the second and third sort of examples arise chiefly (it is claimed) from an incompleteness in our conceptions of the relevant sort—the what the thing in question is. That incompleteness need not prevent us from knowing perfectly well which thing we are referring to. In the concluding section, sortalism is defended against various accusations of anthropocentrism.The paper touches on the interpretation of Heraclitus, Leibniz's theory of clear indistinct ideas, the difficulties of David Lewis's ‘perdurantist’ or stroboscopic view of persistence, four-dimensionalism, and the relation of personal identity both to experiential memory and to the particular bodily physiognomy of a subject. At some points—as in connection with the so-called Only a and b rule—the paper corrects, supplements or extends certain theses or formulations proposed in the author's Sameness and Substance Renewed (2001). (shrink)

This outline for a paper, which develops a compatibilist analysis of abilities, was completed by David Lewis during his sabbatical in the Fall semester of 2000 and is dated 20 January 2001. Starting from the claim that it’s a “Moorean fact” that we are often able to do otherwise, Lewis provides a “simple proof of compatibilism.” He then presents his own account of abilities: S is able to A if and only if there are no obstacles to their A-ing, (...) where an obstacle is a “robust preventer”: something that would cause S not to A, and which “wouldn’t go away if things were just a little different.”. (shrink)

Fragments of Modernity provides a critical introduction to the work of three of the most original German thinkers of the early 20th century. In their different ways, all three illuminated the experience of the modern in urban life, whether in mid-19th-century Paris or in Berlin at the turn of the century or later as the vanguard city of the Weimar Republic. They related the new modes of experiencing the world to the maturation of the money economy (Simmel), the process of (...) rationalization of capital (Kracauer), and the fantasy world of commodity fetishism (Benjamin) - in each case focusing on those fragments of social experience that could best capture the sense of modernity.David Frisby is Reader in Sociology at Glasgow University. Fragments of Modernity is included in the series Studies in Contemporary German Social Thought, edited by Thomas McCarthy. (shrink)

David Luban is one of the world's leading scholars of legal ethics. In this collection of his most significant papers he ranges over such topics as the moral psychology of organisational evil, the strengths and weaknesses of the adversary system, and jurisprudence from the lawyer's point of view. His discussion combines philosophical argument, legal analysis and many cases drawn from actual law practice, and he defends a theory of legal ethics that focuses on lawyers' role in enhancing human dignity (...) and human rights. In addition to an analytical introduction, the volume includes two major previously unpublished papers, including a detailed critique of the US government lawyers who produced the notorious 'torture memos'. It will be of interest to a wide range of readers in both philosophy and law. (shrink)

Hume’s Science of Human Nature is an investigation of the philosophical commitments underlying Hume's methodology in pursuing what he calls ‘the science of human nature’. It argues that Hume understands scientific explanation as aiming at explaining the inductively-established universal regularities discovered in experience via an appeal to the nature of the substance underlying manifest phenomena. For years, scholars have taken Hume to employ a deliberately shallow and demonstrably untenable notion of scientific explanation. By contrast, Hume’s Science of Human Nature sets (...) out to update our understanding of Hume’s methodology by using a more sophisticated picture of science as a model. (shrink)

Dramatic changes in medical technology challenge mankind’s traditional ways of diagnosing death. Death, Brain Death and Ethics examines the concept of death against the background of these changes, as well as ethical and philosophical issues arising from attempts to redefine the boundaries of life. In this book, David Lamb supports the use of brain-related criteria for the diagnosis of death, and proposes a new clinical definition of death based on both medical and philosophical principles. Death, Brain Death and Ethics (...) articulates the case for a brain death standard, while presenting an informed viewpoint on what constitutes the end points of human life. Although the book is written from a philosophical standpoint, it raises fundamental questions regarding the meaning of life and death, and will interest lay-persons, lawyers, and physicians. Death, Brain Death and Ethics is sure to prompt discussion and reflection on some of the philosophical beliefs which underlie clinical practice. (shrink)

Several alleged counterexamples to the definition of ‘intrinsic’ proposed in Rae Langton and David Lewis,‘Defining “Intrinsic”’, are unconvincing. Yet there are reasons for dissatisfaction, and room for improvement. One desirable change is to raise the standard of non‐disjunctiveness, thereby putting less burden on contentious judgements of comparative naturalness. A second is to deal with spurious independence by throwing out just the disjunctive troublemakers, instead of throwing out disjunctive properties wholesale, and afterward reinstating those impeccably intrinsic disjunctive properties that are (...) not troublemakers. (The second of these changes makes the first more affordable.) A third, suggested by Brian Weatherson, would be to invoke the general principle that the intrinsic and the extrinsic characters of things are independent, rather than relying just on one special case of this principle; but it is none too obvious how to do this. (shrink)

I argue that wavefunction realism --- the view that quantum mechanics reveals the fundamental ontology of the world to be a field on a high-dimensional spacetime, must be rejected as relying on artefacts of too-simple versions of quantum mechanics, and not conceptually well-motivated even were those too-simple versions exactly correct. I end with some brief comments on the role of spacetime in any satisfactory account of the metaphysics of extant quantum theories.

David Hume is, arguably, the most important philosopher ever to have written in English. Although best known for his contributions to epistemology, metaphysics, and the philosophy of religion, Hume also made substantial and influential contributions to psychology and the philosophy of mind, ethics, the philosophy of science, political and economic theory, political and social history, and, to a lesser extent, aesthetic and literary theory. All facets of Hume's output are discussed in this volume, the first genuinely comprehensive overview of (...) his work. The picture that emerges is of a thinker who, though critical to the point of scepticism, was nonetheless able to build on that scepticism a profoundly important, and still viable, constructive philosophy. (shrink)