This paper explores the consequences of the theoretical forward activation enzymatic pathway A 0 A 1 A 2 A 3 where E 1 convents A 0 to A 1, E 2 converts A 1 to A 2 and E 3 converts A 2 to A 3. A 0, which is environmentally determined, also serves to activate (or modulate) the activity of E 3 in such a way as to keep the concentration of A 2 ([A 2]) constant at a particular (...) set-point value. For mathematical simplicity, first order rate kinetics are used where k 1, k 2 and k 3 are the rate constants for E 1, E 2, and E 3 respectively. It is shown that if k 3 is modulated appropriately so as keep [A 2] at the setpoint value with a changing upstream [A 0], then the modulation of k 3 must be anticipatory of the dynamics of the biochemical pathway. In other words, the rate of change of k 3, will be a function of [A 0], k 1, k 2, k 3, and the set-point value of [A 2]. If the modulation of k 3 does not perfectly model (anticipate) the reaction pathway of which it is a part, then the actual [A 2] will deviate from the set-point value. This type of anticipatory feed-forward activation may represent an important aspect of biological organization. (shrink)

This paper defends “moral individualism” against various arguments that have been intended to show that membership in the human species or participation in our distinctively human form of life is a sufficient basis for a moral status higher than that of any animal. Among the arguments criticized are the “nature-of-the-kind argument,” which claims that it is the nature of all human beings to have certain higher psychological capacities, even if, contingently, some human beings lack them, and various versions of the (...) idea that there is a special form of life that all human beings share but of which no animal can be a full participant. The paper concludes that none of these arguments succeeds in demonstrating that there are moral reasons to permit animals to be treated less well than members of our own species whose psychological capacities and potential are no higher than those of the animals. (shrink)

Drawing on a range of sources in philosophy and literature, but with particular reference to the work of Heidegger, makes a compelling case for the importance of place in philosophical discourse.

A Russian in Paris -- Russian contexts -- Madmen -- The possessed -- Godmen -- The Hegel lectures -- The last revolution -- Time no more -- The book of the dead -- The later writings -- Nobodies -- Roads or ruins? -- Why finality? -- The grand inquisitor.

A just cause for war is a type of wrong that may make those responsible for it morally liable to military attack as a means of preventing or rectifying it. This claim has implications that conflict with assumptions of the current theory of just war.

THERE’S a well-known scene in Shakespeare’s Henry V in which the King, disguised as an ordinary soldier, is conversing with some of his soldiers on the eve of the battle of Agincourt. Hoping to find or inspire support among them, he remarks: “Methinks I could not die anywhere so contented as in the King’s company, his cause being just and his quarrel honorable.” One soldier replies: “That’s more than we know,” whereupon a second says: “Ay, or more than we should (...) seek after; for we know enough if we know we are the King’s subjects: if his cause be wrong, our obedience to the King wipes the crime of it out of us.”. (shrink)

The main objection to human embryonic stem cell research is that it involves killing human embryos, which are essentially beings of the same sort that you and I are. This objection presupposes that we once existed as early embryos and that we had the same moral status then that we have now. This essay challenges both those presuppositions, but focuses primarily on the first. I argue first that these presuppositions are incompatible with widely accepted beliefs about both assisted conception and (...) monozygotic twinning. I then argue that we never existed as embryos. If this last claim is right, killing an embryo does not kill someone like you or me but merely prevents one of us from existing. (shrink)

Proportionality in the resort to war determines a limit to the amount of harm it can be permissible to cause for the sake of achieving a just cause. It seems to follow that if a war has caused harm up to that limit but has not achieved the just cause, it should be terminated. I argue, however, that this is a mistake. Judgments of proportionality are entirely prospective and harms suffered or inflicted in the past should in general be ignored. (...) Yet past losses that could be partially redeemed by the achievement of the just cause may be an exception. (shrink)

However much one may wish for nonviolent solutions to the problems of unjust and unrestrained human violence that Glover explores in Humanity, some of those problems at present require violent responses. One cannot read his account of the Clinton administration’s campaign to sabotage efforts to stop the massacre in Rwanda in 1994 – a campaign motivated by fear that American involvement would cost American lives and therefore votes – without concluding that Glover himself believes that military intervention was morally required (...) in that case. Military intervention in another state that is intended to stop one group within that state from brutally persecuting or violating the human rights of members of another group is now known as “humanitarian intervention.” Those against whom the intervention is directed are almost always the government and its supporters, though this is not a necessary feature of humanitarian intervention. It is, however, a conceptual condition of humanitarian intervention that it does not occur at the request or with the consent of the government. The use of force within another state with the consent of the government counts as assistance rather than intervention. The principal reason that humanitarian intervention is contentious is that it seems to violate the target state’s sovereign right to control its own domestic affairs. Because humanitarian intervention is a response to human rights violations within the target state, it is regarded as altogether different from wars of defense against aggression. Indeed, since aggression is normally understood to be war against a state that.. (shrink)

In this article I present several challenges to the view that Shelly Kagan calls ‘modal personism’. First, there is a plausible account of our identity that, if true, greatly diminishes the scope of Kagan's view. But the scope of the view is already quite limited because the category of modal persons is restricted to those non-persons that had but have lost the potential to become persons. If the category were to include non-persons that retain the potential to become persons, Kagan's (...) view would have implausible implications about abortion and about the moral status of certain animals. (shrink)

Death and Philosophy presents a wide ranging and fascinating variety of different philosophical, aesthetic and literary perspectives on death. Death raises key questions such as whether life has meaning of life in the face of death, what the meaning of "life after death" might be and whether death is part of a narrative that can be retold in different ways, and considers the various types of death, such as brain death, that challenge mind-body dualism. The essays also include explorations of (...) Chinese, Japanese and Tibetan perspectives on death and why death in some cultures, such as in Mexico's day of the dead, is celebrated. (shrink)

Foreword to the new edition Acknowledgements Introduction: radically interpreting Davidson I. From translation to interpretation 1. The Quinean background 1.1 Radical translation and naturalized epistemology 1.2 Meaning and indeterminacy 1.3 Analytical hypotheses and charity 2. The Davidsonian project 2.1 The development of a theory of meaning 2.2 The project of radical interpretation 2.3 From charity to triangulation..

This paper is a review essay of two collections of essays focused on the work of Alasdair MacIntyre. The review focuses on three core themes. First, it discusses those papers that explore the central role that the relationship between practices and institutions plays in MacIntyre’s critique of modernity. Second, it turns to those papers that examine the foundational role that human needs play in MacIntyre’s ethics. Third, it places in dialogue those papers that defend MacIntyre’s politics as a form of (...) ‘revolutionary Aristotelianism’ with those that contest the soundness of this categorization. (shrink)

Volume 20, Issue 4, May 2020, Page 118-120.

The aim of this essay is to show that there are no easy options for those who are disturbed by the suggestion that infanticide may on occasion be morally permissible. The belief that infanticide is always wrong is doubtfully compatible with a range of widely shared moral beliefs that underlie various commonly accepted practices. Any set of beliefs about the morality of abortion, infanticide and the killing of animals that is internally consistent and even minimally credible will therefore unavoidably contain (...) some beliefs that are counterintuitive. (shrink)

Michael Walzer suggests that our common beliefs about individual responsibility and liability become largely irrelevant in the conduct of war. In conditions of war, everything is changed. Political realists have claimed that war eliminates morality; Walzer claims that war collectivizes it. I believe that conditions of war change nothing at all; they simply make it more difficult to ascertain relevant facts. This is not to say that the principles and laws that do or should govern the activity of war are (...) identical to those governing relations among individuals. Just as domestic law cannot simply restate the principles of individual morality, because the declaration and enforcement of laws have effects that must be taken into account in the formulation of the law, so too the principles, conventions, and laws of war cannot simply restate the principles of individual or international morality. The rules of war have to accommodate our epistemic limitations and to be formulated with a regard for the ways in which their announcement is likely to affect people’s behavior. But they should otherwise reflect as closely as possible the.. (shrink)

The essay argues that the most influential liberal accounts of moral theory (utilitarianism and deontology) assume that human material nature is the seat of desire, and that desire is essentially unsociable. Moral systems are then interpreted as a means of counteracting the essentially self-interested desires that are assumed to ordinarily drive human beings. The essay challenges the normative presuppositions of these arguments. It maintains that liberal moral philosophy must be interpreted in the historical context of the rise of a competitive (...) market society. It then contends that contra liberal moral theory, human beings are neither essentially egoistic nor altruistic, but interdependent. Moral theory is better seen as following from a recognitions of this material interdependence than as an ideal limit on ?naturally? self-interested and competitive behaviour. (shrink)

ABSTRACTThis article argues that the normative foundations and political implications of David Held's cosmopolitan social democracy are insufficient as solutions to the moral and social problems he criticizes. The article develops a life-grounded alternative critique of globalization that roots our ethical duties towards each other in consciousness of our shared needs and capabilities. These ethical duties are best realized in political projects aimed at fundamental long-term transformations in the principles that govern major socio-economic institutions.

This essay focuses on the purported duty—defended by Walter Benjamin but widely assumed in much political theory and practice—of the living to redeem the suffering of those who died as a consequence of oppression, exploitation, and political violence. I consider the cogency and ethical value of this duty from the perspective of a politics grounded in the equal life-value of human beings. For both metaphysical and ethical reasons I conclude that this duty does not obtain, first because the dead cannot (...) experience redemption, and secondly because it is politically counterproductive: it personalizes a pathological form of political resistance which may easily incite further violence and thus perpetuate human suffering and oppression. (shrink)

The article is a critical examination of Marcuse's speculations about the possibility of determining a biological foundation for ethical norms. It considers three key objections to this project: that Marcuse fails to adequately define needs, that he misinterprets Freud, and that, details aside, he fundamentally misunderstands what a `biological' foundation for ethics would entail. The objections are accepted, to varying degrees, as regards the content of Marcuse's argument. The article concludes, however, with a different account of biological foundations designed to (...) rescue the deeper aims of Marcuse's project. Key Words: biology • ethics • foundation • Herbert Marcuse • needs • socialism. (shrink)

The European Legacy, Volume 17, Issue 5, Page 704-705, August 2012.

An essay exploring the failure of the Freethought Movement to repell the Religious Right in American politics.

Key Enlightenment minds are often juxtaposed with their iconic foes, religious conservatives. When discussing the subject of women’s rights, however, this comparison creates a false impression that Enlightenment male thinkers held ideas very much opposed to a dogmatic institution such as the Catholic Church. Ironically, and damaging to their legacy of prejudice-free rationalism, nearly all of the philosophes, many of whom were “freethinking” atheists, viewed woman’s intellectual nature and societal purpose through a prejudice-tainted glass, not unlike the most conservative establishments (...) of their time. Indeed, when it came to the perception of women, the philosophes had less in common with a virulently secular feminist such as Nicholas de Caritat, marquis de Condorcet, than they do with modern conservative Christians who believe women should be treated more fairly, but still cling to gender stereotypes. (shrink)

This paper explores the power of theatre to engage the public and my personal journey using theatre as a research tool in reproductive science. I argue that the capacity of theatre to simultaneously engage the minds and hearts of audience members qua research participants affords audience members the capacity to provide researchers with insightful comments informed by the scientific, social and tacit knowledge derived from the performance, integrated with their lived experience. Theatre is a particularly important research strategy when investigating (...) public understandings and desires about complex issues such as those related to reproductive and genetic science. (shrink)

Interdisciplinary perspectives on landscape, from the philosophical to the geographical, with an emphasis on the overarching concept of place.

This chapter attempts to examine nostalgia as both a mood or disposition in general, and as a mood or disposition that is characteristic of philosophical reflection. Nostalgia is a combination of the Greek nostos, meaning home or the return home, with algos, meaning pain, so that its literal meaning is a pain associated with the return home. Part of this inquiry will involve a rethinking of the mood of nostalgia and what that mood encompasses. Rather than understand the nostalgic as (...) characterized solely by the desire to return to a halcyon past, it is explored through the connotations suggested by its Greek etymology as precisely a longing for the return home—a return that cannot be achieved—a form of homesickness, and so as unsettling rather than comfortable, as bringing with it a sense of the essential questionability of our own being in the world. (shrink)

The dominant view in bioethics is that embryo selection is in general morally preferable to gene editing because the latter involves risks that are absent in the former. What is less widely appreci...

Hubert Dreyfus and Charles Spinosa's argument for 'robust' realism centres on the possibility of our having access to things as they are in themselves and so as having access to things in a way that is not dependent on our 'quotidian concerns or sensory capacities'. Dreyfus and Spinosa claim that our everyday access to things is incapable of providing access of this kind, since our everyday access is holistically enmeshed with our everyday attitudes and concerns. The argument that Dreyfus and (...) Spinosa provide in support of this conclusion seems, however, to depend on illegitimately combining what are really two separate issues: that concerning the independence of the things themselves with the independence of our means of access to those things. Contrary to Dreyfus and Spinosa, the fact that our everyday access to things is necessarily dependent on our everyday attitudes and concerns does not mean that we therefore have access to things only as they 'appear' rather than as they are 'in themselves'. (shrink)