This paper explores the consequences of the theoretical forward activation enzymatic pathway A 0 A 1 A 2 A 3 where E 1 convents A 0 to A 1, E 2 converts A 1 to A 2 and E 3 converts A 2 to A 3. A 0, which is environmentally determined, also serves to activate (or modulate) the activity of E 3 in such a way as to keep the concentration of A 2 ([A 2]) constant at a particular (...) set-point value. For mathematical simplicity, first order rate kinetics are used where k 1, k 2 and k 3 are the rate constants for E 1, E 2, and E 3 respectively. It is shown that if k 3 is modulated appropriately so as keep [A 2] at the setpoint value with a changing upstream [A 0], then the modulation of k 3 must be anticipatory of the dynamics of the biochemical pathway. In other words, the rate of change of k 3, will be a function of [A 0], k 1, k 2, k 3, and the set-point value of [A 2]. If the modulation of k 3 does not perfectly model (anticipate) the reaction pathway of which it is a part, then the actual [A 2] will deviate from the set-point value. This type of anticipatory feed-forward activation may represent an important aspect of biological organization. (shrink)

This groundbreaking inquiry into the centrality of place in Martin Heidegger's thinking offers not only an illuminating reading of Heidegger's thought but a detailed investigation into the way in which the concept of place relates to core philosophical issues. In Heidegger's Topology, Jeff Malpas argues that an engagement with place, explicit in Heidegger's later work, informs Heidegger's thought as a whole. What guides Heidegger's thinking, Malpas writes, is a conception of philosophy's starting point: our finding ourselves already "there," situated (...) in the world, in "place." Heidegger's concepts of being and place, he argues, are inextricably bound together.Malpas follows the development of Heidegger's topology through three stages: the early period of the 1910s and 1920s, through Being and Time, centered on the "meaning of being"; the middle period of the 1930s into the 1940s, centered on the "truth of being"; and the late period from the mid-1940s on, when the "place of being" comes to the fore. The significance of Heidegger as a thinker of place, Malpas claims, lies not only in Heidegger's own investigations but also in the way that spatial and topographic thinking has flowed from Heidegger's work into that of other key thinkers of the past 60 years. (shrink)

While the 'sense of place' is a familiar theme in poetry and art, philosophers have generally given little or no attention to place and the human relation to place. In Place and Experience, Jeff Malpas seeks to remedy this by advancing an account of the nature and significance of place as a complex but unitary structure that encompasses self and other, space and time, subjectivity and objectivity. Drawing on a range of sources from Proust and Wordsworth to Davidson, Strawson (...) and Heidegger, he argues that the significance of place is not to be found in our experience of place so much as in the grounding of experience in place, and that this binding to place is not a contingent feature of human existence, but derives from the very nature of human thought, experience and identity as established in and through place. (shrink)

A range of arguments are presented to demonstrate that (1) human visual orientations are conceptually constituted (concept?bound); (2) the concept?boundedness of visual orientations does not require a cognitivist account according to which a mental process of ?inference? or of ?interpretation? must be postulated to accompany a purely ?optical? registration of ?wavelengths of light?, ?photons?, or contentless ?information'; (3) concept?bound visual orientations are not all instances of ?seeing as?, contrary to some currently prominent cognitivist accounts; (4) the dispute between cognitivist and (...) realist accounts about the phenomenon of ?seeing as? is spurious, and is based upon a confusion about the fundamental analytical distinction made by Wittgenstein between ?seeing? and ?seeing as'; (5) ?perceiving?, ?seeing?, and ?seeing as? are but three of a large array of verbs of human visual orientation, and are not ?master categories? under which one can subsume these other modalities; (6) one cannot deduce a continuity of human visual orientation from a continuity of photon?photoreceptor interaction, a point we characterize as the ?staggered character? of human visual orientations; (7) detailed attention to the grammars of the diverse verbs of human visual orientation can open up a domain of study which we here refer to as a ?praxiology of perception'; (8) the nature of such an inquiry can be illustrated with exemplary reference to the analysis of the properties of ?noticing? as embedded in courses of practical action; and (9) such arguments, which claim that existing perceptual theories overly homogenize what is involved in visual orientations to the world, parallel those of Stroll, who proposes that standard accounts of ?what is perceived? overly homogenize the perceptible environment. (shrink)

In recent years, various attempts have been made to advance a project sometimes characterized as "discursive psychology". Grounded in what its proponents term "social constructionism", the discursive approach to the elucidation of 'mental' phenomena is here contrasted to an ethnomethodological position informed by the later work of Wittgenstein. In particular, it is argued that discursive psychology still contains Cartesian residua, notwithstanding its professed objective of expurgating Cartesian thought from the behavioral sciences. One principal issue has been the confusion of "conceptual (...) analysis" with the empirical study of speech practices. If these distinct enterprises are conflated, the critical achievements of conceptual analysis are obscured or even misconstrued. A different picture of how best to analyze human conduct and mentality emerges if the lessons of Wittgensteinian grammatical analysis are preserved and extended, one more compatible with several themes in ethnomethodology. (shrink)

In his book, The Scientific Image, van Fraassen lucidly draws an alternative to scientific realism, which he calls "Constructive Empiricism". In this epistemological theory, the concept of observability plays the pivotal role: acceptable theories may be believed only where what they say solely concerns observables. Van Fraassen develops a concept of observability which is, as he admits, vague, relative, science-dependent, and anthropocentric. I draw out unacceptable consequences of each of these aspects of his concept. Also, I argue against his assumption (...) that "empirical adequacy" is the same thing as "saving the phenomena", according to his sense of the expressions. (shrink)

The idea of place--topos--runs through Martin Heidegger's thinking almost from the very start. It can be seen not only in his attachment to the famous hut in Todtnauberg but in his constant deployment of topological terms and images and in the situated, "placed" character of his thought and of its major themes and motifs. Heidegger's work, argues Jeff Malpas, exemplifies the practice of "philosophical topology." In Heidegger and the Thinking of Place, Malpas examines the topological aspects of Heidegger's thought (...) and offers a broader elaboration of the philosophical significance of place. Doing so, he provides a distinct and productive approach to Heidegger as well as a new reading of other key figures--notably Kant, Aristotle, Gadamer, and Davidson, but also Benjamin, Arendt, and Camus. Malpas, expanding arguments he made in his earlier book _Heidegger's Topology_, discusses such topics as the role of place in philosophical thinking, the topological character of the transcendental, the convergence of Heideggerian topology with Davidsonian triangulation, the necessity of mortality in the possibility of human life, the role of materiality in the working of art, the significance of nostalgia, and the nature of philosophy as beginning in wonder. Philosophy, Malpas argues, begins in wonder and begins in place and the experience of place. The place of wonder, of philosophy, of questioning, he writes, is the very topos of thinking. (shrink)

This paper explores the relevance of the Non-Identity Problem to explaining the wrongness of causing climate change.

In Felicitous Underspecification, Jeffrey King draws our attention to a rich and underexplored collection of linguistic data. These are uses of context-sensitive expressions which seem perfectly felicitous despite being such that, on plausible assumptions, the context in which they are used falls short of securing for them a unique semantic value. This raises an immediate puzzle: if, as King argues, these uses of expressions really do lack unique semantic values in context, how can they—as they manifestly do—make contributions to the (...) conversations in which they occur? King answers this question with a novel theory of conversational updating. Here I focus less on this theory than on King’s examples, and consider some ways of accommodating them without positing felicitous underspecification. In some cases I give some reasons for thinking that the alternative explanation is superior. But my aim is less to establish this conclusion than to suggest some new options for thinking about these examples, and hopefully by so doing to advance the conversation about the data to which King has drawn our attention. (shrink)

In the course of commenting on the third chapter of Frances Kamm’s Ethics for Enemies, this article proposes an analysis of the notion of a just cause for war, according to which there is a just cause only when those whom it is necessary to attack as a means of achieving some aim are potentially morally liable to be attacked. The remainder of the article then discusses issues of proportionality, particularly in relation to several distinct forms of moral justification for (...) harming or killing people. Among the central questions addressed is what the conditions are in which good effects of a war that are independent of the achievement of the just cause may count in determining whether the war would be proportionate. (shrink)

There is a paucity of research into the prevalence of academic dishonesty within Canada compared to other countries. Recently, there has been a call for a better understanding of the particular characteristics of educational integrity in Canada so that Canada can more meaningfully contribute to current discussions surrounding academic integrity. Here, we present findings from student and faculty surveys conducted within a medium-sized Canadian university. These surveys probed perceptions towards, and experiences with, academic dishonesty, in which we aimed to understand (...) how students and faculty regarded academically dishonest practices during their postsecondary careers. We also aimed to understand how often students engaged in, and faculty had witnessed, academic dishonesty, whether or not witnessing incidents of academic dishonesty corresponded with gender, year of experience, highest level of educational attainment, discipline, or their personal perceptions towards the importance of academic honesty, and whether students had been adequately taught what constitutes academic dishonesty. We found that an overwhelming majority of students viewed academic honesty as important, and that most students reported not engaging in academic dishonesty themselves despite 45.8% reporting that they had witnessed others engage in academic dishonesty. We also found that students were more likely to witness cheating as their postsecondary experience increased, that witnessing varied across disciplines and educational attainment, and that witnessing varied with student perceptions. However, we found no such patterns in faculty responses, but found that faculty are split on whether or not they believe incidents of academic honesty are increasing. (shrink)

Programming languages are, at the same time, instruments and communicative artifacts that evolve rapidly through use. In this paper I describe an online computing platform called BioBike. BioBike is a trading zone where biologists and programmers collaborate in the development of an extended vocabulary and functionality for computational genomics. In the course of this work they develop interactional expertise with one another’s domains. The extended BioBike vocabulary operates on two planes: as a working programming language, and as a pidgin in (...) the conversation between the biologists and engineers. The flexibility that permits this community to dynamically extend BioBike’s working vocabulary—to form new pidgins—makes BioBike unique among computational tools, which usually are not themselves adapted through the collaborations that they facilitate. Thus BioBike is itself a crucial feature—which it is tempting to refer to as a participant—in the developing interaction.Keywords: Trading zones; Collaboration; Interactional expertise; Genomics; Computer programming languages; Lisp. (shrink)

In the fusillade he lets fly against Foss (1984), Bourgeois (1987) sometimes hits a live target. I admit that I went beyond the letter of van Fraassen's The Scientific Image (1980), making inferences and drawing conclusions which are often absurd. I maintain, however, that the absurdities must be charged to van Fraassen's account. While I cannot redress every errant shot of Bourgeois, his essay reveals the need for further discussion of the concepts of the phenomena and the observables as used (...) by van Fraassen. (shrink)

Lucretius wrote: “Look back at the eternity that passed before we were born, and mark how utterly it counts to us as nothing. This is a mirror that Nature holds up to us, in which we may see the time that shall be after we are dead. Is there anything terrifying in the sight – anything depressing – anything that is not more restful than the soundest sleep?”1 The argument is repeated, a couple of millennia later, by Vladimir Nabokov, who (...) opens his memoir with the observation that “our existence is but a brief crack of light between two eternities of darkness. Although the two are identical twins, man, as a rule, views the prenatal abyss with more calm than the one he is heading for (at some forty-five hundred heartbeats an hour).”. (shrink)

Some of the questions Professor Miller addresses are concerned with proportionality, a notion whose complexities are only beginning to be appreciated. My modest ambition in this comment is to try to sharpen these questions and provide some assistance in thinking about them.

Are the words in our natural language which we use to speak about natural and social phenomena actually laden with preexisting (and hence corrigible) theoretical commitments, full-blown "ontologies," or even metaphysics? Or can we appeal to rules for their use in adjudicating the sense (or otherwise) of any scientific or philosophical innovation? These questions arise most commonly in the context of claims about scientific "transformations," especially "scientific revolutions." Cognitive science, for example, announces such a "revolution" in its conceptualizations of the (...) true nature of the "mind," "thought," "intelligence," "understanding," and so on. In this paper I shall argue that Wittgenstein's reflections on "grammar" enable us to dissolve many of the perplexities that confront us when we invoke Kuhnian "incommensurability" in distinguishing between genuine scientific revolutions and pseudo-revolutions. Indeed, the Kuhnian thesis itself is seen to depend on a range of contestable claims about "words" and "meanings.". (shrink)

Both Kant and Davidson view the existence of mental states, and so the possibility of mental content, as dependent on the obtaining of a certain unity among such states. And the unity at issue seems also to be tied, in the case of both thinkers, to a form of self-reflexivity. No appeal to self-reflexivity, however, can be adequate to explain the unity of consciousness that is necessary for the possibility of content- it merely shifts the focus of the question from (...) the unity of consciousness in general to the unity of self-reflexivity in particular. Through a comparison of the views of Kant and Davidson on these matters, the nature of the unity of consciousness is explored, in relation to both the idea of the unity of the self and the unity that would seem to be required for the possibility of content. These forms of unity are seen to be indeed connected, and to be grounded, in Davidson and perhaps also in Kant, in organized, oriented, embodied activity. (shrink)

In his most distinctly political book, The Public and Its Problems, John Dewey describes a never-ending process of achieving democratic governance, in which obstacles to such governance inevitably emerge, and are progressively overcome. However, even in that evidently political work, Dewey still emphasizes that there is a “distinction between democracy as a social idea and political democracy as a system of government. . . . The idea of democracy is a wider and fuller idea than can be exemplified in the (...) state even at its best” (143). The typical political bodies that exercise legislative, executive, administrative, and judicial power are not the only institutions that significantly impact how individuals live .. (shrink)

SummaryDonald Davidson's account of the interrelation between attitudes, and linguistic and non‐linguistic behaviour is a thoroughly holistic one. The project of radical interpretation itself embodies a holistic approach to the interpretative task. Yet Davidson also accepts a degree of indeterminacy in interpretation. Davidson's commitment to both holism and indeterminacy can give rise to a problem in the Davidsonian position. That problem is explained and a solution proposed. The indeterminacy thesis is thereby clarified, as is the nature of Davidsonian holism.

Embodied approaches to cognition see abstract thought and language as grounded in interactions between mind, body, and world. A particularly important challenge for embodied approaches to cognition is mathematics, perhaps the most abstract domain of human knowledge. Conceptual metaphor theory, a branch of cognitive linguistics, describes how abstract mathematical concepts are grounded in concrete physical representations. In this paper, we consider the implications of this research for the metaphysics and epistemology of mathematics. In the case of metaphysics, we argue that (...) embodied mathematics is neutral in the sense of being compatible with all existing accounts of what mathematical entities really are. However, embodied mathematics may be able to revive an older position known as psychologism and overcome the difficulties it faces. In the case of epistemology, we argue that the evidence collected in the embodied mathematics literature is inconclusive: It does not show that abstract mathematical thinking is constituted by metaphor; it may simply show that abstract thinking is facilitated by metaphor. Our arguments suggest that closer interaction between the philosophy and cognitive science of mathematics could yield a more precise, empirically informed account of what mathematics is and how we come to have knowledge of it. (shrink)

In his most recent work on John Dewey, John Shook explores Dewey’s political thought in order to illuminate Dewey’s conception of democracy and demonstrate the interlocking quality of his democratic and educational theories. As the book’s subtitle indicates, Shook sees democracy and education as inseparable enterprises for Dewey, with democracy being fundamentally defined by the continuous education of individuals, and with specifically educational spaces serving to directly promote this definitive purpose of democracy. The particular educational goal that Shook identifies in (...) Dewey’s thought is the cultivation of “social intelligence,” a quality that allows individuals to effectively engage.. (shrink)

Without complete and accurate status information, a project manager’s ability to monitor progress, allocate resources effectively, and detect and respond to problems is greatly diminished, and this can lead to impaired project performance. Many different factors can contribute to intentional misreporting of status information by project members to the project manager. In this study, the impact of organizational ethical climate was assessed through the analysis of responses from 228 project members drawn from a variety of ongoing information systems projects. Our (...) results revealed that project members who perceived their organization to be one in which rules are followed strictly tended to misreport less, while those operating in an environment dominated by personal self-interest tended to misreport more. Somewhat surprisingly, the existence of a caring, team-spirited environment did not appear to have an impact on misreporting behaviors. Implications for researchers and project managers are discussed. (shrink)

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McMahan challenges the assumption that respect for self-determination requires an almost exceptionless doctrine of nonintervention by first defining the notions of "intervention" and "self-determination," and then analyzing Walzer's doctrine of nonintervention.

Philosophical Books 46, no. 1 (2005): 1-3.

Despite its prominence in Peirce’s best-known works, the notion of fixed, stable, or settled belief (I will follow Peirce in using these terms more or less interchangeably) has received relatively little explicit attention. Need a belief be permanently stable in order to count as fixed? Or, to take the other extreme, does a belief count as fixed as long as it is currently stable? More fundamentally, what is involved in predicating stability of a belief? Talk of stability suggests a disposition (...) to resist being undermined, and so the question arises of how resistant to what sorts of undermining influences a belief needs to be in order to count as fixed in Peirce’s sense. Does Peirce, especially in “The Fixation of.. (shrink)

Walter Sinnott-Armstrong and Franklin Miller have presented an account of why killing is wrong that implies it can be permissible to kill certain human beings in order to use their organs for transplantation.1 Since I am going to criticise their arguments, I will begin by applauding their willingness to defend an unpopular position and by registering my agreement with their substantive conclusion about organ procurement. The criticisms I will offer are intended to be friendly in spirit; but they are also, (...) of course, meant to be effective.Sinnott-Armstrong and Miller argue that the wrongness of killing is reducible to the wrongness of disabling, in particular, the wrongness of totally disabling. ‘The rule against disabling,’ they write, ‘fully explains all that is bad and wrong with… killing.’1One might think that their view is just a slight modification of the familiar view that the wrongness of killing is reducible to the wrongness of harming. According to this view, killing is normally gravely wrong because it inflicts on its victim a particularly grievous harm by depriving him of all the good that his future life would otherwise have contained. If the authors' view were just a restatement of this harm-based account of the wrongness of killing, one might conclude that their emphasis on disability is needlessly provocative. But in fact their view is quite different. This is because disabling is only one form of harming. On might seriously harm a person—for example, by causing him to experience mild chronic pain for the remainder of his life—without in any way disabling him. He would retain all his abilities but would be less comfortable while exercising them. Because there are thus forms of harming that are not instances of disabling, a rule …. (shrink)

I am greatly honored that these four distinguished moral and legal theorists, who have all made substantial and important contributions to our understanding of the problems with which I am concerned in my book, have been willing to engage themselves so constructively with my arguments. The published book will be significantly better, or less bad, as a result of my having had to address their challenges. I find myself in substantial agreement with much of what each commentator has to say (...) and concede that on some points they have proven me wrong. But I am obstinate by nature, and perhaps a little obtuse, and thus am prepared to resist some of their suggestions, however sensible they may seem. (shrink)

This essay argues that considerations of justice that govern the morality of self-defense are also relevant in some cases in which organs are allocated for transplantation in conditions of scarcity. The essay's main substantive claim is that in general alcoholics are morally liable to be assigned a lower priority in the distribution of livers for transplantation because of their own responsibility for their need for a transplant. There are, however, practical obstacles to giving lower priority in the distribution of medical (...) resources generally to those who are responsible for their own illnesses, and it may seem unfair to single out alcoholics but not others for lower priority. (shrink)

How does one explain an interest in ethics? In my case the interest has never been “intellectual” or “academic.” I have never been drawn to metaethics. Rather, I have always been aware that there’s a lot wrong in the world and I have wanted to do what I could to help put it right. I grew up in the American south during the years of the Vietnam War and the civil rights movement. That gave me a lot to think about. (...) I still have a poster that I took o¤ a telephone pole near where I lived in rural South Carolina that reads “Don’t be half a man, join the Klan.”. (shrink)