If one formulates Helmholtz's ideas about perception in terms of modern-day theories one arrives at a model of perceptual inference and learning that can explain a remarkable range of neurobiological facts. Using constructs from statistical physics it can be shown that the problems of inferring what cause our sensory inputs and learning causal regularities in the sensorium can be resolved using exactly the same principles. Furthermore, inference and learning can proceed in a biologically plausible fashion. The ensuing scheme rests on (...) Empirical Bayes and hierarchical models of how sensory information is generated. The use of hierarchical models enables the brain to construct prior expectations in a dynamic and context-sensitive fashion. This scheme provides a principled way to understand many aspects of the brain's organisation and responses. In this paper, we suggest that these perceptual processes are just one emergent property of systems that conform to a free-energy principle. The free-energy considered here represents a bound on the surprise inherent in any exchange with the environment, under expectations encoded by its state or configuration. A system can minimise free-energy by changing its configuration to change the way it samples the environment, or to change its expectations. These changes correspond to action and perception, respectively, and lead to an adaptive exchange with the environment that is characteristic of biological systems. This treatment implies that the system's state and structure encode an implicit and probabilistic model of the environment. We will look at models entailed by the brain and how minimisation of free-energy can explain its dynamics and structure. (shrink)

If one formulates Helmholtz’s ideas about perception in terms of modern-day theories one arrives at a model of perceptual inference and learning that can explain a remarkable range of neurobiological facts. Using constructs from statistical physics it can be shown that the problems of inferring what cause our sensory inputs and learning causal regularities in the sensorium can be resolved using exactly the same principles. Furthermore, inference and learning can proceed in a biologically plausible fashion. The ensuing scheme rests on (...) Empirical Bayes and hierarchical models of how sensory information is generated. The use of hierarchical models enables the brain to construct prior expectations in a dynamic and context-sensitive fashion. This scheme provides a principled way to understand many aspects of the brain’s organisation and responses. In this paper, we suggest that these perceptual processes are just one emergent property of systems that conform to a free-energy principle. The free-energy considered here represents a bound on the surprise inherent in any exchange with the environment, under expectations encoded by its state or configuration. A system can minimise free-energy by changing its configuration to change the way it samples the environment, or to change its expectations. These changes correspond to action and perception, respectively, and lead to an adaptive exchange with the environment that is characteristic of biological systems. This treatment implies that the system’s state and structure encode an implicit and probabilistic model of the environment. We will look at models entailed by the brain and how minimisation of free-energy can explain its dynamics and structure. (shrink)

The Repugnant Conclusion served an important purpose in catalyzing and inspiring the pioneering stage of population ethics research. We believe, however, that the Repugnant Conclusion now receives too much focus. Avoiding the Repugnant Conclusion should no longer be the central goal driving population ethics research, despite its importance to the fundamental accomplishments of the existing literature.

There is a deeply entrenched view in philosophy and physics, the closed systems view, according to which isolated systems are conceived of as fundamental. On this view, when a system is under the influence of its environment this is described in terms of a coupling between it and a separate system which taken together are isolated. We argue against this view, and in favor of the alternative open systems view, for which systems interacting with their environment are conceived of as (...) fundamental, and the environment's influence is represented via the dynamical equations that govern the system's evolution. Taking quantum theories of closed and open systems as our case study, and considering three alternative notions of fundamentality: (i) ontic fundamentality, (ii) epistemic fundamentality, and (iii) explanatory fundamentality, we argue that the open systems view is fundamental, and that this has important implications for the philosophy of physics, the philosophy of science, and for metaphysics. (shrink)

We say that A≤LRB if every B-random set is A-random with respect to Martin–Löf randomness. We study this relation and its interactions with Turing reducibility, classes, hyperimmunity and other recursion theoretic notions.

It is argued that those who defend the Everett, or ‘many-worlds’, interpretation of quantum mechanics should embrace what we call the general quantum theory of open systems (GT) as the proper framework in which to conduct foundational and philosophical investigations in quantum physics. GT is a wider dynamical framework than its alternative, standard quantum theory (ST). This is true even though GT makes no modifications to the quantum formalism. GT rather takes a different view, what we call the open systems (...) view, of the formalism; i.e., in GT, the dynamics of systems whose physical states are fundamentally represented by density operators are represented as fundamentally open as specified by an in general non-unitary dynamical map. This includes, in principle, the dynamics of the universe as a whole. We argue that the more general dynamics describable in GT can be physically motivated, that there is as much prima facie empirical support for GT as there is for ST, and that GT could be fully in the spirit of the Everett interpretation—that there might, in short, be little reason for an Everettian not to embrace the more general theoretical landscape that GT allows one to explore. (shrink)

This thought-provoking book discusses the concept of progress in economics and investigates whether any advance has been made in its different spheres of research. The authors look back at the history, successes and failures of their respective fields and thoroughly examine the notion of progress from an epistemological and methodological perspective. The idea of progress is particularly significant as the authors regard it as an essentially contested concept which can be defined in many ways – theoretically or empirically; locally or (...) globally; or as encouraging or impeding the existence of other research traditions. The authors discuss the idea that for progress to make any sense there must be an accumulation of knowledge built up over time rather than the replacement of ideas by each successive generation. Accordingly, they are not concerned with estimating the price of progress, reminiscing in the past, or assessing what has been lost. Instead they apply the complex mechanisms and machinery of the discipline to sub-fields such as normative economics, monetary economics, trade and location theory, Austrian economics and classical economics to critically assess whether progress has been made in these areas of research. -/- Bringing together authoritative and wide-ranging contributions by leading scholars, this book will challenge and engage those interested in philosophy, economic methodology and the history of economic thought. It will also appeal to economists in general who are interested in the advancement of their profession. (shrink)

Dondeyne, A. Pluriformiteit en eenheid van de filosofie.--Peperzak, A. Wegwijzers naar een dialogiek?--Boer, T. de. De eindigheid van de mens en de oneindigheid van de waarheid.--Hollak, J. Wijsgerige reflecties over de scheppingsidee : St. Thomas, Hegel en de Grieken.--Plat, J. Kants kritiek op de rationele psychologie.--Melsen, A. van. Wijsgerige antropologie en de ontwikkeling van natuurwetenschap en techniek.--Buytendijk, F. Het pathisch aspect van de eindigheid.--Struyker Boudier, H. 's Bergbeklimmers einder.

Previously conducted structural magnetic resonance imaging (MRI) studies on the neuroanatomical correlates of mathematical abilities and competencies have a number of methodological limitations. Besides small sample sizes, the majority of these studies have employed voxel-based morphometry (VBM) – a method that, although it is easily to implement, has some major drawbacks. Taking this into account, the current study is the first to investigate in a large sample of typically developed adults the associations between mathematical abilities and variations in brain surface (...) structure by using surface-based morphometry (SBM). SBM is a method that also allows the investigation of brain morphometry by avoiding the pitfalls of VBM. Eighty-nine young adults were tested with a large battery of psychometric tests to measure mathematical competencies in four different areas: (1) simple arithmetic, (2) complex arithmetic, (3) higher-order mathematics and (4) numerical intelligence. In addition, we asked participants for their mathematics grade of their final school exam. Inside the MRI scanner, we collected high-resolution T1-weighted anatomical images from each subject. SBM analyses were performed with the computational anatomy toolbox (CAT12) and indices for cortical thickness, for cortical surface complexity, for gyrification and for sulcal depth were calculated. Further analyses revealed associations between (1) the cortical surface complexity of the right superior temporal gyrus and numerical intelligence, (2) the depth of the right central sulcus and adults’ ability to solve complex arithmetic problems and (3) the depth of the left parieto-occipital sulcus and adults’ higher-order mathematics competence. Interestingly, no relationships with previously reported brain regions were observed, thus, suggesting the importance of similar research to confirm the role of the brain regions found in this study. (shrink)

ZusammenfassungDieser Beitrag konzentriert sich auf eine starke und auf eine schwache Seite von Bayers Zugang zu Luthers Theologie. So wird als Stärke angesehen, dass das Thema der Rechtfertigung in Luthers Theologie als allumfassend angesetzt wird. Dagegen besteht eine Schwäche in der Art und Weise, wie Bayer durch Luthers Dialektik der zwei Arten, in denen Gott sich verbirgt – also verborgen »unter dem Gegenteil« und absolut verborgen – hindurch bricht, indem er die beiden trennt und diese Aufteilung als Kriterium verwendet, um (...) zwischen einer Periode, in der Luther die reformatorische Einsicht vollständig ausarbeitet, und einem vor-reformatorischen Luther zu unterscheiden. Diese Luther-Interpretation sollte nochmals überdacht werden, denn sie verneint die Entsprechung und die kontrapunktisch zu verstehende Beziehung zwischen dieser doppelten Verborgenheit im Lichte des »offenbaren Gottes«. Ein ähnliches Problem taucht dann auf, wenn Bayer die Rede vom dreieinigen Gott, die ausschließlich am Evangelium orientiert ist, unterscheidet von einer allgemeinen Art und Weise, von Gott zu reden, die allein auf dem Gesetz basiert. Luthers Vorstellung, dass die Unterscheidung zwischen Gesetz und Evangelium vollständig in Gottes Offenbarung des Evangeliums integriert ist, widerspricht einer solchen Unterscheidung. Dieser Beitrag betrachtet nicht nur die Unterscheidung zwischen einem unreifen und einem reifen Luther, der alle Implikationen der reformatorischen Einsicht ausgearbeitet hat, als unnötig, sondern er würdigt den jungen Luther als einen Theologen, der in der Lage ist, dasjenige zusammen zu halten, was beim späten Luther auseinander zu fallen droht. Glücklicherweise beinhaltet Bayers Studie auch Anknüpfungsmöglichkeiten für eine solche Interpretation Luthers, die die positiven ebenso wie die negativen Aspekte beider Arten der Verborgenheit ebenso wie Gesetz und Evangelium in einem einzigen kontinuierlichen Prozess integriert.SummaryThis contribution concentrates on one strong and one weak side of Bayer's approach to Luther's theology. It finds a strength in the universally implemented theme of justification in Luther's theological thought. A weakness is however found in the way Bayer breaks through Luther's dialectics concerning the dual way God hides himself – i. e. hidden ‘under the opposite’ and absolutely hidden – by separating them and using this division as a criterion to distinguish between the period where Luther had fully worked out the insight of the Reformation and the pre-Reformation Luther. Such an interpretation of Luther needs to be reconsidered because it neglects the correspondence and the contrapuntal relation between this double hiddeness in the light of the ‘revealed God’.A similar problem arises when Bayer divides speaking about the triune God, which is exclusively orientated towards the Gospel, from a general way of speaking about God, which is only based on the Law. Luther's idea that the distinction between Law and Gospel is fully integrated into God's revelation of the Gospel contradicts such a division.This contribution considers not only a distinction between an immature and a mature Luther who has worked out all the implications of the reformation insight unnecessary, but appreciates the young Luther as a theologian who is capable of holding together what the later Luther is in danger of letting fall apart. Fortunately, in Bayer's study there are also openings for a Luther interpretation that includes the positive as well as the negative aspect of both kinds of hiddeness and of Law and Gospel in a single continuous process. (shrink)

Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in metabolic rate found among and within individual animals of the same species. Research in this area has been hampered by differences in approach, terminology and methodology, and the context in which measurements are made. Recent advances provide important opportunities to identify and address the key questions in the field. By bringing together (...) researchers from different areas of biology and biomedicine, we describe and evaluate these developments and the insights they could yield, highlighting the need for more standardisation across disciplines. We conclude with a list of important questions that can now be addressed by developing a common conceptual and methodological toolkit for studies on metabolic variation in animals. (shrink)

A number of distinct definitions ofsustainable agriculture have been proposed. In this paper we criticize two such definitions, primarily for conflating sustainability with other objectives such as economic viability and ecological integrity. Finally, we propose and defend a definition which avoids our objections to the other definitions.

This is a review of the issue of randomness in quantum mechanics, with special emphasis on its ambiguity; for example, randomness has different antipodal relationships to determinism, computability, and compressibility. Following a philosophical discussion of randomness in general, I argue that deterministic interpretations of quantum mechanics are strictly speaking incompatible with the Born rule. I also stress the role of outliers, i.e. measurement outcomes that are not 1-random. Although these occur with low probability, their very existence implies that the no-signaling (...) principle used in proofs of randomness of outcomes of quantum-mechanical measurements should be reinterpreted statistically, like the second law of thermodynamics. In three appendices I discuss the Born rule and its status in both single and repeated experiments, review the notion of 1-randomness that in various guises was investigated by Kolmogorov and others and treat Bell’s Theorem and the Free Will Theorem with their implications for randomness. (shrink)

The volume documents, and makes an original contribution to, an astonishing period in twentieth-century philosophy—the progress of Arne Naess's ecophilosophy from its inception to the present. It includes Naess's most crucial polemics with leading thinkers, drawn from sources as diverse as scholarly articles, correspondence, TV interviews and unpublished exchanges. The book testifies to the skeptical and self-correcting aspects of Naess's vision, which has deepened and broadened to include third world and feminist perspectives. Philosophical Dialogues is an essential addition to the (...) literature on environmental philosophy. (shrink)

ObjectiveIn this study we used functional magnetic resonance imaging to investigate whether motor imagery of handwriting and circle drawing activates a similar handwriting network as writing and drawing itself.MethodsEighteen healthy right-handed participants wrote the German word “Wellen” and drew continuously circles in a sitting and lying position to capture kinematic handwriting parameters such as velocity, pressure and regularity of hand movements. Afterward, they performed the same tasks during fMRI in a MI and an executed condition.ResultsThe kinematic analysis revealed a general (...) correlation of handwriting parameters during sitting and lying except of pen pressure during drawing. Writing compared to imagined writing was accompanied by an increased activity of the ipsilateral cerebellum and the contralateral sensorimotor cortex. Executed compared to imagined drawing revealed elevated activity of a fronto–parieto-temporal network. By contrasting writing and drawing directly, executed writing induced an enhanced activation of the left somatosensory and premotor area. The comparison of the MI of these tasks revealed a higher involvement of occipital activation during imagined writing.ConclusionThe kinematic results pointed to a high comparability of writing in a vertical and horizontal position. Overall, we observed highly overlapping cortical activity except of a higher involvement of motor control areas during motor execution. The sparse difference between writing and drawing can be explained by highly automatized writing in healthy individuals. (shrink)

To Aristotle, spoken words are symbols, not of objects in the world, but of our mental experiences related to these objects. Presently there are two major strands of interpretation of Aristotle’s concept of the linguistic sign. First, there is the structuralist account offered by Coseriu (Geschichte der Sprachphilosophie. Von den Anfängen bis Rousseau, 2003 [1969], pp. 65–108) whose interpretation is reminiscent of the Saussurean sign concept. A second interpretation, offered by Lieb (in: Geckeler (Ed.) Logos Semantikos: Studia Linguistica in Honorem (...) Eugenio Coseriu 1921–1981, 1981) and Weidemann (in: Schmitter (Ed.) Geschichte der Sprachtheorie 2. Sprachtheorien der abendländischen Antike, 1991), says that Aristotle’s concept of the linguistic sign is similar to the one presented in Ogden and Richard’s (The meaning of meaning: A study of the influence of language upon thought and of the science of symbolism, 1970 [1923]) semiotic triangle. This paper starts off with an introductory outline of the so-called phýsei-thései discussion which started during presocratic times and culminated in Plato’s Cratylus. Aristotle’s concept of the linguistic sign is to be regarded as a solution to the stalemate position reached in the Cratylus. Next, a discussion is offered of both Coseriu’s and Lieb’s analysis. We submit that Aristotle’s concept of the linguistic sign shows features of both Saussure’s and Ogden and Richards’s sign concept but that it does not exclusively predict one of the two. We argue that Aristotle’s concept of the linguistic sign is based on three different relations which together evince his teleological as well empiricist point of view: one internal (symbolic) relation and two external relations, i.e. a likeness relation and a relation katà synthéken. (shrink)

ABSTRACT: Confronted with the “wrong kind of reason problem”, several proponents of the fitting attitude analysis of emotional values have argued in favor of an epistemic approach. In such a view, an emotion fits its object because the emotion is correct. However, I argue that we should reorient our search towards a practical approach because only practical considerations can provide a satisfying explanation of the fittingness of emotional responses. This practical approach is partially revisionist, particularly because it is no longer (...) an analysis of final value and because it is relativistic. View HTML Send article to KindleTo send this article to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle. Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. Find out more about the Kindle Personal Document Service.The FA Analysis of Emotional Values and Practical Reasons*Volume 51, Issue 1Stephane Lemaire DOI: https://doi.org/10.1017/S0012217312000224Your Kindle email address Please provide your Kindle [email protected]@kindle.com Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Dropbox To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Dropbox. The FA Analysis of Emotional Values and Practical Reasons*Volume 51, Issue 1Stephane Lemaire DOI: https://doi.org/10.1017/S0012217312000224Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Google Drive To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Google Drive. The FA Analysis of Emotional Values and Practical Reasons*Volume 51, Issue 1Stephane Lemaire DOI: https://doi.org/10.1017/S0012217312000224Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Export citation Request permission. (shrink)

Bonjour (1985: 101 and 1999: 124) and other coherence theorists of justification before him (e.g. Ewing, 1934: 246) have complained that we do not have a satisfactory analysis of the notion of coherence. The problem with existing accounts of coherence is that they try to bring precision to our intuitive notion of coherence independently of the particular role that it is meant to play within the coherence theory of justification (e.g Lewis, 1946: 338). This is a mistake: it does not (...) make any sense to ask what precisely makes for a more coherent information set independently of the particular role that coherence is supposed to play within the context in question. What is this context and what is this role? The coherence theory of justification rides on a particular common sense intuition: when we gather information from less than fully reliable sources, then the more coherent the story that materializes is, the more confident we may be, ceteris paribus. Within the context of information gathering from certain types of sources, coherence is a property of stories which plays a confidence boosting role. But what features should the information sources have, so that the coherence of the information set is indeed a determinant of our degree of confidence in question? And what goes into the ceteris paribus clause? In other words, what other factors affect our confidence in the information set in question? (shrink)

Under the influence of a narrowly understood scientific legal positivism, jurisprudence has neglected interdisciplinary research for a long time. However, today there are strong practical and scholarly reasons for an interdisciplinary analysis of law triggered, e.g., by bioethics, life sciences, economics and ecology. And yet the very subject matter of law shimmering between normativity and descriptivity seems to resist all attempts to be taken in by common enterprises across disciplines: How then is the necessary interdisciplinary research in jurisprudence possible without (...) abandoning its core, legal dogmatics? This question was discussed at a special working group during the IVR-World Congress in Cracow. The papers have been polished and updated for publication. The volume falls into two parts: One is directed at the basic conceptual and institutional questions of interdisciplinary research in jurisprudence; the other one concentrates on one fruitful and highly important field of interdisciplinary research, constitutionalism. The volume brings together a truly international and in itself interdisciplinary group of experts in the field, from Finland to Brazil and from Spain to Greece. (shrink)

A consistent finding in research on conditional reasoning is that individuals are more likely to endorse the valid modus ponens (MP) inference than the equally valid modus tollens (MT) inference. This pattern holds for both abstract task and probabilistic task. The existing explanation for this phenomenon within a Bayesian framework (e.g., Oaksford & Chater, 2008) accounts for this asymmetry by assuming separate probability distributions for both MP and MT. We propose a novel explanation within a computational-level Bayesian account of reasoning (...) according to which “argumentation is learning”. We show that the asymmetry must appear for certain prior probability distributions, under the assumption that the conditional inference provides the agent with new information that is integrated into the existing knowledge by minimizing the Kullback-Leibler divergence between the posterior and prior probability distribution. We also show under which conditions we would expect the opposite pattern, an MT-MP asymmetry. (shrink)

This study examined the hypothesis that a key process in conditional reasoning with concrete premises involves on-line retrieval of information about potential alternate antecedents. Participants were asked to solve reasoning problems with causal conditional premises (If cause P then effect Q). These premises were inserted into short contexts. The availability of potential alternatives was varied from one context to another by adding statements that explicitly invalidated one or more of these alternatives (i.e., other causes that lead to the effect Q). (...) The invalidated alternatives differed in the degree of their semantic association to the consequent term (Q). The results show that the effect of invalidating one or more potential alternatives on the two uncertain logical forms, AC and DA, was largely determined by their relative associative strength. These results strongly support a model for conditional reasoning with causal premises that supposes that a key element in responding to the uncertain logical forms is on-line retrieval of at least one potential alternative antecedent. (shrink)

In September 1998 the Bundesrztekammer, i.e., the German Medical Association, published new principles concerning terminal medical care. Even before publication, a draft of these principles was very controversial, and prompted intense public debate in the mass media. Despite some of the critics' suspicions that the principles prepared the way for liberalization of active euthanasia, euthanasia is unequivocally rejected in the principles. Physician-assisted suicide is considered to violate professional medical rules. In leaving aside some of the notions customarily used in the (...) euthanasia debate, e.g., passive euthanasia, the principles emphasize the obligation of physicians to offer and the right of patients to receive palliative care. The principles explicitly list modalities of basic treatment that are indispensable in all cases, such as the obligation to satisfy hunger and thirst. This statement is meant to resolve the dispute on nutrition and hydration at the end of life, as it shifts the focus of care from maintaining physiological parameters to satisfying subjective needs. For patients in a persistent vegetative state, artificial feeding is held to be obligatory. Yet, the principles make reference to recent German jurisdiction which permit the stopping of artificial feeding if it is in accordance with the patient's presumed will. Additionally, the wording concerning this issue is found to remain unclear. Patients' autonomy is strengthened by explicitly welcoming advance directives as a means to ascertain patients' wills. The principles mark some changes compared to earlier documents. They deserve careful analysis and should be considered in the international debate on issues concerning the end of life. (shrink)

In this paper a unified framework for dealing with a broad family of propositional multimodal logics is developed. The key tools for presentation of the logics are the notions of closure relation operation and monotonous relation operation. The two classes of logics: FiRe-logics (finitely reducible logics) and LaFiRe-logics (FiRe-logics with local agreement of accessibility relations) are introduced within the proposed framework. Further classes of logics can be handled indirectly by means of suitable translations. It is shown that the logics from (...) these classes have the finite model property with respect to the class of ♦-formulae, i.e. each ♦-formula has a ℒ-model iff it has a finite ℒ-model. Roughly speaking, a ♦-formula is logically equivalent to a formula in negative normal form without occurrences of modal operators with necessity force. In the proof we introduce a substantial modification of Claudio Cerrato's filtration technique that has been originally designed for graded modal logics. The main core of the proof consists in building adequate restrictions of models while preserving the semantics of the operators used to build terms indexing the modal operators. (shrink)

Name der Zeitschrift: Klio Jahrgang: 99 Heft: 2 Seiten: 747-752.

BackgroundNarrative reviews are the commonest type of articles in the medical literature. However, unlike systematic reviews and randomized controlled trials (RCT) articles, for which formal instruments exist to evaluate quality, there is currently no instrument available to assess the quality of narrative reviews. In response to this gap, we developed SANRA, the Scale for the Assessment of Narrative Review Articles.MethodsA team of three experienced journal editors modified or deleted items in an earlier SANRA version based on face validity, item-total correlations, (...) and reliability scores from previous tests. We deleted an item which addressed a manuscript’s writing and accessibility due to poor inter-rater reliability. The six items which form the revised scale are rated from 0 (low standard) to 2 (high standard) and cover the following topics: explanation of (1) the importance and (2) the aims of the review, (3) literature search and (4) referencing and presentation of (5) evidence level and (6) relevant endpoint data. For all items, we developed anchor definitions and examples to guide users in filling out the form. The revised scale was tested by the same editors (blinded to each other’s ratings) in a group of 30 consecutive non-systematic review manuscripts submitted to a general medical journal.ResultsRaters confirmed that completing the scale is feasible in everyday editorial work. The mean sum score across all 30 manuscripts was 6.0 out of 12 possible points (SD 2.6, range 1–12). Corrected item-total correlations ranged from 0.33 (item 3) to 0.58 (item 6), and Cronbach’s alpha was 0.68 (internal consistency). The intra-class correlation coefficient (average measure) was 0.77 [95% CI 0.57, 0.88] (inter-rater reliability). Raters often disagreed on items 1 and 4.ConclusionsSANRA’s feasibility, inter-rater reliability, homogeneity of items, and internal consistency are sufficient for a scale of six items. Further field testing, particularly of validity, is desirable. We recommend rater training based on the “explanations and instructions” document provided with SANRA. In editorial decision-making, SANRA may complement journal-specific evaluation of manuscripts—pertaining to, e.g., audience, originality or difficulty—and may contribute to improving the standard of non-systematic reviews. (shrink)

Engineered microbes are of great potential utility in biotechnology and basic research. In principle, a cell can be built from scratch by assembling small molecule sets with auto‐catalytic properties. Alternatively, DNA can be isolated or directly synthesized and molded into a synthetic genome using existing genomic blueprints and molecular biology tools. Activating such a synthetic genome will yield a synthetic cell. Here we examine obstacles associated with this latter approach using a model system whereby a donor genome from H. influenzae (...) is fragmented, and the pieces are then modified and reassembled stepwise in an E. coli host cell. There are obstacles associated with this strategy related to DNA transfer, DNA replication, cross‐talk in gene regulation and compatibility of gene products between donor and host. Encouragingly, analysis of gene expression indicates widespread transcription of H. influenzae genes in E. coli, and analysis of gap locations in H. influenzae and other microbial genome assemblies reveals few genes routinely incompatible with E. coli. In conclusion, rebuilding and booting a genome remains a feasible and pragmatic approach to creating a synthetic microbial cell. BioEssays 29:580–590, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

The emerging consensus in the philosophy of cognition is that cognition is situated, i.e., dependent upon or co-constituted by the body, the environment, and/or the embodied interaction with it. But what about emotions? If the brain alone cannot do much thinking, can the brain alone do some emoting? If not, what else is needed? Do (some) emotions (sometimes) cross an individual's boundary? If so, what kinds of supra-individual systems can be bearers of affective states, and why? And does that make (...) emotions ?embedded? or ?extended? in the sense cognition is said to be embedded and extended? Section 2 shows why it is important to understand in which sense body, environment, and our embodied interaction with the world contribute to our affective life. Section 3 introduces some key concepts of the debate about situated cognition. Section 4 draws attention to an important disanalogy between cognition and emotion with regard to the role of the body. Section 5 shows under which conditions a contribution by the environment results in non-trivial cases of ?embedded? emotions. Section 6 is concerned with affective phenomena that seem to cross the organismic boundaries of an individual, in particular with the idea that emotions are ?extended? or ?distributed.? (shrink)

Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

We tentatively propose two guiding principles for the construction of theories of physics, which should be satisfied by a possible future theory of quantum gravity. These principles are inspired by those that led Einstein to his theory of general relativity, viz. his principle of general covariance and his equivalence principle, as well as by the two mysterious dogmas of Bohr's interpretation of quantum mechanics, i.e. his doctrine of classical concepts and his principle of complementarity. An appropriate mathematical language for combining (...) these ideas is topos theory, a framework earlier proposed for physics by Isham and collaborators. Our "Principle of general tovariance" states that any mathematical structure appearing in the laws of physics must be definable in an arbitrary topos (with natural numbers object) and must be preserved under so-called geometric morphisms. This principle identifies geometric logic as the mathematical language of physics and restricts the constructions and theorems to those valid in intuitionism: neither Aristotle's principle of the excluded third nor Zermelo's Axiom of Choice may be invoked. Subsequently, our "Equivalence principle" states that any algebra of observables (initially defined in the topos Sets) is empirically equivalent to a commutative one in some other topos. (shrink)