Whole–exome sequencing (WES) has increased our ability to analyze large parts of the human genome, bringing with it a plethora of ethical, legal, and social implications. A topic dominating discussion of WES is identification of “secondary findings” (SFs), defined as the identification of risk in an asymptomatic individual unrelated to the indication for the test. SFs can have considerable psychosocial impact on patients and families, and patients with an SF may have concerns regarding genomic privacy and genetic discrimination. The Genetic (...) Information Nondiscrimination Act of 2008 (GINA) currently excludes protections for members of the military. This may cause concern in military members and families regarding genetic discrimination when considering genetic testing. In this report, we discuss a case involving a patient and family in which a secondary finding was discovered by WES. The family members have careers in the U.S. military, and a risk–predisposing condition could negatively affect employment. While beneficial medical management changes were made, the information placed exceptional stress on the family, who were forced to navigate career–sensitive “extra–medical” issues, to consider the impacts of uncovering risk–predisposition, and to manage the privacy of their genetic information. We highlight how information obtained from WES may collide with these issues and emphasize the importance of genetic counseling for anyone undergoing WES. (shrink)

Trois composantes régissent notre vie en société et sont de nature à faire évoluer la règle de droit ainsi que le fonctionnement de la justice : le droit, la morale et l’éthique. Existe-t-il une hiérarchie entre ces trois normes? Quelles sont les interférences entre ces constantes qui constituent les piliers tant de la démocratie, que de l’État de droit et de la justice? Dès lors, se pose la question de la légalité face à la morale et à l’éthique. Un acte (...) pourrait-il être légal et non conforme à l’éthique, à la morale? Un acte pourrait-il être regardé comme illégal alors qu’il serait conforme à l’éthique, à la morale? Au-delà de cette réflexion d’ordre philosophique et sociétale, il est légitime de s’interroger sur la vérité judiciaire, son contenu et ses éventuelles contradictions… Il est tout aussi incontournable de rappeler que la déontologie des avocats est inscrite dans un cadre règlementaire tout en puisant sa raison d’être dans l’éthique. Nous en concluons que Droit et Justice doivent prendre en considération l’exigence éthique. Il ne saurait exister le moindre affrontement entre droit et éthique dès lors que bien qu’autonomes, ces deux normes se complètent et permettent à la société d’évoluer dans un cadre harmonisé. (shrink)

The feminization of agriculture narrative has been reproduced in development literature as an oversimplified metric of empowerment through changes in women’s labor and managerial roles with little attention to individuals’ heterogeneous livelihoods. Grounded in feminist political ecology, we sought to critically understand how labor and managerial feminization interact with changing agricultural practices. Working with a local NGO as part of an international, donor-funded research-for-development project, we conducted semi-structured interviews, focus group discussions, and participant observation with over 100 farmers in Mid-Western (...) Nepal in 2017. Household structure and headship are dynamic in the context of male out-migration, pushing women to take on new agricultural duties and increasing household labor responsibilities. In this context, decision-making processes related to agricultural management and new cultivation practices illustrate ongoing renegotiations of gender and cultivation practices within and beyond the household. We contend that the heterogeneity of household power dynamics muddies the empowering impacts of migration and emphasize the importance of community spaces as a locus of subjectivity formation and social value. We conclude that FPE can illuminate complexities of power, space, and individual responses to socio-ecological conditions that challenge the current feminization of agriculture framework. (shrink)

Dynamic intra-individual variability (IIV) in cardiac vagal control across multiple situations is believed to contribute to adaptive cognition under stress; however, a dearth of research has empirically tested this notion. To this end, we examined 25 U.S. Army Soldiers (all male, Mean Age= 30.73, SD = 7.71) whose high-frequency heart rate variability (HF-HRV) was measured during a resting baseline and during three conditions of a shooting task (training, low stress, high stress). Response inhibition was measured as the correct rejection of (...) friendly targets during the low and high stress conditions. We tested the association between the standard deviation of HF-HRV across all four task conditions (IIV in vagal control) and changes in response inhibition between low and high stress. Greater differences in vagal control between conditions (larger IIV) were associated with higher tonic vagal control during rest, and stronger stress-related decreases in response inhibition. These results suggest that flexibility in vagal control is supported by tonic vagal control, but this flexibility also uniquely relates to adaptive cognition under stress. Findings are consistent with neurobehavioral and dynamical systems theories of vagal function. (shrink)

This book will remain timeless in its study of Aristotle's objective grasp of reality. The book's uniqueness lies in its aim of letting Aquinas himself speak on the subject of metaphysics. The work embraces both a history of philosophy and Aristotle's subsequent reasoning toward God as pure act.

ABSTRACTThis article presents an ecolinguistic analysis of a popular digital simulation game, Animal Crossing: New Leaf. As the popularity and immersive capability of digital gaming continue...

Most studies examining gene-environment effects on self-regulation focus on outcomes early childhood or adulthood. However, only a few studies investigate longitudinal effects during middle childhood and adolescence and compare two domains of early caregiving. In a longitudinal follow-up with a sample of N = 87, we studied the effects of differences in the DRD4 tandem repeat polymorphisms and two domains of early maternal caregiving quality on children’s personality development using Block’s California Child Q-Set at age six and age 12 and (...) on problem behavior at ages six and seven. Early maternal regulation quality predicted later ego-resiliency and aggressiveness. In addition, significant gene-environment interactions revealed that children with the 7+ DRD4 tandem repeat polymorphism and poor maternal regulation quality in infancy showed lower scores in ego-resiliency and higher scores in ego-undercontrol and CCQ aggressiveness. In contrast, children who had experienced effective maternal regulation in infancy showed a comparable level in personality traits and problem behavior as the DRD4 7- group independent of the levels of maternal regulatory behavior. Similarly, longitudinal caregiving × DRD4 interactions were found for behavior problems in middle childhood, especially for oppositional-aggression, inattentive-hyperactivity, and social competence. Early caregiving effects were only found for maternal regulation quality, but not for maternal responsiveness. Effective early maternal regulation in infancy can moderate the negative effect of DRD4 7+ on children’s self-regulation in middle childhood and adolescence. However, maternal responsiveness has no comparable effects. It seems relevant to consider several dimensions of early caregiving and to also measure the environment in more detail in gene-environment studies. (shrink)

Aristotle on Teaching examines teaching in general, and analyzes the objects, procedures, and order found in all student learning, furnishing the guidelines for the culminating section on the inductive and deductive procedures underlying all teaching. It explores Aristotle's doctrine to discover its relevance for the art of teaching, defined as the act of explaining the truth to those being taught, through the lucid explanations of Thomas Aquinas on the writings of Aristotle.

This book is based on the natural patterns of human thinking as analyzed in Aristotle's formal logic. As an introductory text for either the undergraduate or high school student, it presents only the basic rules needed for defining, judging, and reasoning. The author carefully outlines her presentations and provides familiar illustrations. The book also contains numerous exercises which utilize well-known topics.

This paper explicates the teleological assessment of argumentative will. The author recommends a reassessment of the understanding and approach to argumentation in critical thinking courses and suggests that it should be guided and structured by Aristotle's doctrine of the mean. The author outlines rules guided by Aristotle's doctrine to form a teleological assessment of various form of argument. A critical thinker, according to the author, must see what an arguer's objectives are and how argument should be evaluated in light of (...) those objectives. (shrink)

What ethical questions does neuroscience raise and help to answer? Neuroethics blends philosophical analysis with modern brain science to address central questions within this growing field: · Is free will an illusion? · Does brain stimulation impair a patient's autonomy? · Does having a mental disorder excuse bad behavior? · Is addiction a brain disease? · Should we trust our gut feelings in ethics and politics? · Should we alter our brains to become better people? · Is human reasoning bound (...) to be biased by our values? · Can brain science be trusted to read the minds of criminals and consumers? This book provides an opinionated tour through captivating cases and a close examination of the philosophical issues and scientific evidence. Joshua May's lively and accessible writing style makes it an indispensable resource for students and scholars in both the sciences and humanities. (shrink)

Some researchers have concluded that nonverbal recognition is generally superior to verbal recognition memory performance. The present study involved two experiments designed to assess claims of superior nonverbal memory. Experiment 1 compared performance for letter (common words) and nonletter (meaningful line drawings) items with matched high-imagery values. Experiment 2 compared performance for matched low-imagery items consisting of letters (pseudowords) and nonletter items (geometric matrices). Performance did not differ significantly between verbal and nonverbal items in either experiment, although the expected effects (...) of presentation rate and type of retrieval task were significant. It was concluded that recognition memory performance is not necessarily dependent upon the “verbalness ” or “non-verbalness ” of stimulus items. (shrink)

What the Church teaches and why on issues of euthanasia, invitro fertilization, genetic counseling, assisted suicide, living wills, persistent vegetative state, organ transplants, and more.

Aristotle and Confucius are pivotal figures in world history; nevertheless, Western and Eastern cultures have in modern times largely abandoned the insights of these masters. Remastering Morals provides a book-length scholarly comparison of the ethics of Aristotle and Confucius. May Sim's comparisons offer fresh interpretations of the central teachings of both men. More than a catalog of similarities and differences, her study brings two great traditions into dialog so that each is able to learn from the other. This is essential (...) reading for anyone interested in virtue-oriented ethics. (shrink)

The burgeoning science of ethics has produced a trend toward pessimism. Ordinary moral thought and action, we’re told, are profoundly influenced by arbitrary factors and ultimately driven by unreasoned feelings. This book counters the current orthodoxy on its own terms by carefully engaging with the empirical literature. The resulting view, optimistic rationalism, shows the pervasive role played by reason, and ultimately defuses sweeping debunking arguments in ethics. The science does suggest that moral knowledge and virtue don’t come easily. However, despite (...) the heavy influence of automatic and unconscious processes that have been shaped by evolutionary pressures, we needn’t reject ordinary moral psychology as fundamentally flawed or in need of serious repair. Reason can be corrupted in ethics just as in other domains, but a special pessimism about morality in particular is unwarranted. Moral judgment and motivation are fundamentally rational enterprises not beholden to the passions. (shrink)

A discussion of the intersections between Aristotle's works: Ethics and Metaphysics. It debates the ways in which - and even the extent to which - the two texts illuminate one another, examine Aristotle's methods and intellectualism and analyse issues of matter, form, potency and art.

Chapter. 1. Logical. Form. as. a. Level. of. Linguistic. Representation. What is the relation of a sentence's syntactic form to its logical form? This issue has been of central concern in modern inquiry into the semantic properties of natural ...

In defending his interest-relative account of knowledge in Knowledge and Practical Interests (2005), Jason Stanley relies heavily on intuitions about several bank cases. We experimentally test the empirical claims that Stanley seems to make concerning our common-sense intuitions about these bank cases. Additionally, we test the empirical claims that Jonathan Schaffer seems to make in his critique of Stanley. We argue that our data impugn what both Stanley and Schaffer claim our intuitions about such cases are. To account for these (...) results, one must develop a better conception of the connection between a subject's interests and her body of knowledge than those offered by Stanley and Schaffer. (shrink)

Are individuals responsible for the consequences of actions taken by their community? What about their community's inaction or its attitudes? In this innovative book, Larry May departs from the traditional Western view that moral responsibility is limited to the consequences of overt individual action. Drawing on the insights of Arendt, Jaspers, and Sartre, he argues that even when individuals are not direct participants, they share responsibility for various harms perpetrated by their communities.