Research ethics review is a critical aspect of the research governance framework for human subjects research. This usually requires that research protocols be submitted to a research ethics committee for review and approval. This has led to very rapid developments in the domain of research ethics, as RECs proliferate all over the globe in rhyme with the explosion in human subjects research. The work of RECs has increasingly become elaborate, complex, and in many cases urgent, necessitating supporting rules and procedures (...) of operation. Guidelines for elaborating standard operating procedures for the functioning of RECs have also been proposed. The SOPs of well-placed and well-resourced RECs have tended to pay much attention to details, resulting, as a consequence, in generally long, elaborate, intricate and complex SOPs; a model that can hardly be replicated by other committees, equally under ethics review pressures, but working under much more constraining conditions in resource-destitute environments. In this paper, we looked at the content and length of SOPs from African RECs and compared them to the World Health Organization ’s guidelines as the gold standard. We also looked at the SOPs from the Ethics Review and Consultancy Committee of the Cameroon Bioethics Initiative that we elaborated in a simplified way in 2013, and compared them to the WHO’s guidelines and to the other SOPs. Sixteen SOPs from 14 African countries were collected from various sources. Their average length was of 30 pages. By comparison to the guidance of the WHO, only six of them were found acceptable with more than 70 % of the criteria from the gold standard that were fully described. Among those six, two of them were very long and detailed, while the four remaining SOPs ranged from 16 to 24 pages. The ERCC SOPs are seven pages long but maintain all that is of essence for the rigorous, efficient and timely review of protocols. We are convinced that, because of their brevity, simplicity, clarity and user-friendliness, the ERCC SOPs recommend themselves as a model template to, at least, committees similarly situated and/or circumstanced as the ERCC of the Cameroon Bioethics Initiative is. In fact, brevity, clarity, simplicity and user-friendliness are recognized values. Whatever is brief and clear is better than what is not and saves time. What is simple and user-friendly is better than what is not even though the two have the same aims because it saves both time and mental energy. And if this be true in general, it is even truer of the context and its peculiar constraints that we are addressing. (shrink)

Although the world has experienced remarkable progress in health care since the last half of the 20th century, global health inequalities still persist. In some poor countries life expectancy is between 37-40 years lower than in rich countries; furthermore, maternal and infant mortality is high and there is lack of access to basic preventive and life-saving medicines, as well a high prevalence of neglected diseases, HIV/AIDS, tuberculosis, and malaria. Moreover, globalization has made the world more connected than before such that (...) health challenges today are no longer limited within national or regional boundaries, making all persons equally vulnerable. Because of this, diseases in the most affluent countries are closely connected with diseases in the poorest countries. In this paper, we argue that, because of global health inequalities, in a situation of equal vulnerability, there is need for global solidarity not only as a means of reducing health inequalities, but also as a way of putting up a united force against global health challenges. We argue for an African approach to solidarity in which the humanity of a person is not determined by his/her being human or rational capacity, but by his/her capacity to live a virtuous life. According to this view of solidarity, because no one is self-sufficient, no individual can survive alone. If we are to collectively flourish in a world where no individual, nation or region has all the health resources or protection needed for survival, we must engage in solidarity where we remain compassionate and available to one another at all times. (shrink)

The introduction of genomics and biobanking methodologies to the African research context has also introduced novel ways of doing science, based on values of sharing and reuse of data and samples. This shift raises ethical challenges that need to be considered when research is reviewed by ethics committees, relating for instance to broad consent, the feedback of individual genetic findings, and regulation of secondary sample access and use. Yet existing ethics guidelines and regulations in Africa do not successfully regulate research (...) based on sharing, causing confusion about what is allowed, where and when. In order to understand better the ethics regulatory landscape around genomic research and biobanking, we conducted a comprehensive analysis of existing ethics guidelines, policies and other similar sources. We sourced 30 ethics regulatory documents from 22 African countries. We used software that assists with qualitative data analysis to conduct a thematic analysis of these documents. Surprisingly considering how contentious broad consent is in Africa, we found that most countries allow the use of this consent model, with its use banned in only three of the countries we investigated. In a likely response to fears about exploitation, the export of samples outside of the continent is strictly regulated, sometimes in conjunction with regulations around international collaboration. We also found that whilst an essential and critical component of ensuring ethical best practice in genomics research relates to the governance framework that accompanies sample and data sharing, this was most sparingly covered in the guidelines. There is a need for ethics guidelines in African countries to be adapted to the changing science policy landscape, which increasingly supports principles of openness, storage, sharing and secondary use. Current guidelines are not pertinent to the ethical challenges that such a new orientation raises, and therefore fail to provide accurate guidance to ethics committees and researchers. (shrink)

Background The rise in genomic and biobanking research worldwide has led to the development of different informed consent models for use in such research. This study analyses consent documents used by investigators in the H3Africa (Human Heredity and Health in Africa) Consortium. Methods A qualitative method for text analysis was used to analyse consent documents used in the collection of samples and data in H3Africa projects. Thematic domains included type of consent model, explanations of genetics/genomics, data sharing and feedback of (...) test results. Results Informed consent documents for 13 of the 19 H3Africa projects were analysed. Seven projects used broad consent, five projects used tiered consent and one used specific consent. Genetics was mostly explained in terms of inherited characteristics, heredity and health, genes and disease causation, or disease susceptibility. Only one project made provisions for the feedback of individual genetic results. Conclusion H3Africa research makes use of three consent models—specific, tiered and broad consent. We outlined different strategies used by H3Africa investigators to explain concepts in genomics to potential research participants. To further ensure that the decision to participate in genomic research is informed and meaningful, we recommend that innovative approaches to the informed consent process be developed, preferably in consultation with research participants, research ethics committees and researchers in Africa. (shrink)

Many ethical concerns surrounding human genetics studies remain unresolved. We report here the situation in Cameroon.Objectives: To describe the profile of human genetic studies that used Cameroonian DNA samples, with specific focus on i) the research centres that were involved, ii) authorship, iii) population studied, iv) research topics and v) ethics disclosure, with the aim of raising ethical issues that emerged from these studies.Method: Bibliometric Studies; we conducted a PubMed-based systematic review of all the studies on human genetics that used (...) Cameroonian DNA samples from 1989 to 2009.Results and Discussion: Fifty articles were identified, involving predominantly research centres from Europe (64%) and America (32%). Only 7 (14%) Cameroonian institutions and 14 (28%) Cameroonian authors were associated with these publications.At least 52% of publications were devoted to population genetics (variation/migration patterns) amongst 30 Cameroonian ethnic groups. Very few studies concerned public health related genetic issues and only 5 (10%) references were found for hemoglobinopathies like sickle cell anaemia. Almost all DNA samples are ‘banked’ outside of the African continent.Capacity building, rights to the genetic information and benefits to the individuals, communities and populations who contribute to these studies are addressed.Conclusions: 1) Our data suggests the need for a wider debate towards building capacity and addressing ethical issues related to human genomic research in sub-Saharan Africa and specifically in Cameroon; 2) National ethical guidelines and regulations concerning the collection, use and storage of human DNA are urgently needed in Cameroon. (shrink)

The rise of genomic studies in Africa – not least due to projects funded under H3Africa – is associated with the development of a small number of biorepositories across Africa. For the ultimate success of these biorepositories, the creation of cell lines including those from selected H3Africa samples would be beneficial. In this paper, we map ethical challenges in the creation of cell lines.

Background Universities in Cameroon are playing an active part in HIV/AIDS research and much of this research is carried out by students, usually for the purpose of a dissertation/thesis. Student theses/dissertations present research findings in a much more comprehensive manner and have been described as the stepping-stone of a budding scientist’s potential in becoming an independent researcher. It is therefore important to verify how students handle issues of research ethics. Method Theses/dissertations on HIV/AIDS that described research studies involving the use (...) of human research participants were screened to verify if research ethics approval and informed consent were obtained and documented. The contents of the consent forms were also qualitatively analyzed. Results Of 174 theses/dissertations on HIV, ethics approval was documented in 17 and informed consent in 77. Research ethics approval was first mentioned at all in 2002 and highly reported in the year 2007. Evidence of ethics approval was found for the first time in 2005 and informed consent first observed and evidenced in 1997. Ethics approval was mostly reported by students studying for an MD and was not reported in any Bachelors’ degree dissertation. Informed consent was also highly reported in MD theses followed by undergraduate theses. Voluntary participation and potential benefits of the study were some of the common aspects dealt with in most of the consent forms. The right to discontinue participation in the study and management of residual samples were scarcely ever mentioned. Conclusions Overall, and given the current state of the art of research ethics around the world, student-scientists in Cameroon would seem to be merely kidding with research ethics. It is thus essential that training in health research ethics be incorporated in the curriculum of universities in Cameroon in order that the next generation of scientists may be better equipped with thorough knowledge and practice of HRE. This, we believe, would be one way of fighting the occurrence of research scandals, which have not yet abated significantly, especially those arising from negligence or inexcusable ignorance. (shrink)

Concerns related to the future of work has precipitated various studies aimed at ensuring that the labour market is a place where people can earn a living, work in dignity, and flourish as human beings. Studies on labour market inequalities and how macroeconomic policies can be used to address such inequalities are also plentiful. What macroeconomic studies have often failed to do, however, is highlight the differences _between_ individuals in the labour market. This is important, especially in an economy with (...) large inequalities, such as South Africa. These inequalities are further entrenched given that wage employment is the primary mode of income generation for the majority of households in South Africa. The purpose of this study was to investigate changes in quality of work at the microeconomic level in relation to changes in the macroeconomy, using a decent work index built from secondary labour force survey data. The data show that changes in the macroeconomic policy environment coincide with differential outcomes for different groups of workers in the labour market, with women benefitting in terms of quality of work during times in which the government undertakes an expansionary fiscal approach, although only in occupation groups which are male-dominated. The study also finds, however, that in some occupation groups, quality of work does not change in relation to shifts in the macroeconomy. The study highlights the need for microeconomic analyses to inform macroeconomic policies to ensure that expected outcomes are distributed in the intended way. (shrink)

Cognitive developmental evidence is sometimes conscripted to support ''naturalized epistemology'' arguments to the effect that a general epistemic stance leads children to build theory-like accounts of underlying properties of kinds. A review of the evidence suggests that what prompts conceptual acquisition is not a general epistemic stance but a series of category-specific intuitive principles that constitute an evolved ''natural metaphysics''. This consists in a system of categories and category-specific inferential processes founded on definite biases in prototype formation. Evidence for this (...) system provides a better understanding of the limited ''plasticity'' of ontological commitments as well as a computationally plausible account of their initial state, avoiding ambiguities about innateness. This may provide a starting point for a ''naturalized epistemology'' that takes into account evolved properties of human conceptual structures. (shrink)

Cognitive developmental evidence is sometimes conscripted to support ''naturalized epistemology'' arguments to the effect that a general epistemic stance leads children to build theory-like accounts of underlying properties of kinds. A review of the evidence suggests that what prompts conceptual acquisition is not a general epistemic stance but a series of category-specific intuitive principles that constitute an evolved ''natural metaphysics''. This consists in a system of categories and category-specific inferential processes founded on definite biases in prototype formation. Evidence for this (...) system provides a better understanding of the limited ''plasticity'' of ontological commitments as well as a computationally plausible account of their initial state, avoiding ambiguities about innateness. This may provide a starting point for a ''naturalized epistemology'' that takes into account evolved properties of human conceptual structures. (shrink)

Postmortem reproduction refers to normally unnatural situations that are made possible by modern medical technology. It's a definition that applies to a situation in which one parent of an offspring is dead at the time of conception of the offspring or at the time of birth of the offspring. It is a situation which raises complex and multifactorial dilemma as with most issues that concern decisions over human life; accordingly, this discussion of its ethical ramifications is not intended to be (...) exhaustive, but illustrative. (shrink)

Les normes somptuaires édictées dans les communes de Bologne, Venise, Pérouse, Sienne font apparaître l’usage aux XIIIe-XVe siècles de banquets réservés aux femmes, particulièrement à l’occasion des fiançailles et des noces. Ces traces confirment d’autres observations sur les solidarités féminines dans ces sociétés mais ne sont guère relayées par les textes littéraires, dont les auteurs sont pratiquement toujours des hommes ; elles suggèrent cependant de poursuivre l’enquête. The sumptuary laws enacted by the City-states of Bologna, Venice, Perugia, Siena bring to (...) light the fact that the banquets reserved to women were not uncommon practice between the XIIIth and the XVth century, particularly on the occasion of engagements or weddings. Such traces confirm other observations concerning solidarity among women in those urban societies, though they are not mentioned in literary texts (authors being practically always men) ; yet encourage scholars to go on investigating. (shrink)

Au cours du xixe siècle, porter l’uniforme est devenu un élément constitutif de l’identité militaire, particulièrement en France où le service militaire s’est progressivement universalisé à la veille de la Première Guerre mondiale. Objet matériel doté de fonctions symboliques, l’uniforme introduit l’historien au cœur du fonctionnement d’un milieu social qui est alors l’un des laboratoires de la masculinité. Décrit, critiqué, modifié par les médecins militaires soucieux de fonctionnalité et de bien-être, il donne à voir un corps qui demeure cependant largement (...) façonné, redressé par une armature de tissu dissimulant une réalité beaucoup moins idéale. Son port est le fruit d’un long apprentissage qui agrège le jeune soldat à la communauté masculine qui l’entoure. Offert au regard d’autrui, à celui des femmes tout particulièrement, il construit une identité masculine en quête de reconnaissance et se trouve situé, par conséquent, au cœur des processus de construction de la différence sexuée. (shrink)

Au cours du xixe siècle, porter l’uniforme est devenu un élément constitutif de l’identité militaire, particulièrement en France où le service militaire s’est progressivement universalisé à la veille de la Première Guerre mondiale. Objet matériel doté de fonctions symboliques, l’uniforme introduit l’historien au cœur du fonctionnement d’un milieu social qui est alors l’un des laboratoires de la masculinité. Décrit, critiqué, modifié par les médecins militaires soucieux de fonctionnalité et de bien-être, il donne à voir un corps qui demeure cependant largement (...) façonné, redressé par une armature de tissu dissimulant une réalité beaucoup moins idéale. Son port est le fruit d’un long apprentissage qui agrège le jeune soldat à la communauté masculine qui l’entoure. Offert au regard d’autrui, à celui des femmes tout particulièrement, il construit une identité masculine en quête de reconnaissance et se trouve situé, par conséquent, au cœur des processus de construction de la différence sexuée. (shrink)

This paper examines how, building on earlier filmic representations such as Ousmane Sembene’s La Noire de… and Abderrahmane Sissako’s Bamako, Khady Sylla’s Le Monologue de la muette traces a continuum of women’s exploitation, from slavery to colonization to globalization.

Le volontarisme de la RDA en direction des femmes et les mesures favorisant leur intégration au monde du travail sont des aspects bien connus du régime socialiste est-allemand. Celui-ci reprit en effet à son compte l’idée héritée du marxisme faisant de l’activité professionnelle des femmes la condition première de leur émancipation. L’existence en RDA d’une recherche sur les femmes n’a pourtant pas bénéficié de la même notoriété que la politique de l’État est-allemand en leur faveur. Outre le caractère confidentiel de (...) ses publications, l’activité du Conseil scientifique « La femme dans la société socialiste » de 1964 à 1990 fut considérée après la chute du mur comme nulle et non avenue en raison de l’absence de distance critique avec le parti au pouvoir. La nouvelle génération de chercheuses est-allemandes récusa en effet toute dimension féministe à cette recherche officielle. Pourtant, l’étude de l’histoire de ce Conseil révèle une réalité plus nuancée. (shrink)

La notion d’imagination est centrale dans l’œuvre de Thomas Hobbes et pourtant sous-étudiée. Derrière une apparente homogénéité du corpus, la notion d’imagination subit des évolutions importantes au fil des décennies. Hobbes la comprend peu à peu comme une activité indissociablement cognitive et affective. L’intérêt pour le rôle des affects dans la vie mentale va conduire Hobbes à placer l’imagination au cœur de son anthropologie et de son système politique. Cet article défend l’idée selon laquelle Hobbes fait de l’imagination le fondement (...) de l’institution sociale et politique. (shrink)

Cet article analyse l'impact de la colonisation sur le statut des femmes en l'abordant sous l'angle des droits politiques tels quils furent définis dans le cadre des institutions coloniales : droit de vote, problématique du suffrage, participation aux assemblées… Quels furent les facteurs qui déterminèrent l'accès plus ou moins tardif des femmes à la sphère politique? De quelle marge de manœuvre disposèrent les colonisées face à des politiques qui restèrent longtemps marquées par des mentalités paternalistes? La comparaison des approches française (...) et britannique met en évidence les ambivalences des colonisateurs qui considérèrent les femmes tour à tour comme d'éternelles mineures, des alliées potentielles, à l'instar des femmes chefs de Sierra Leone, ou comme une nouvelle « ressource » politique au moment des indépendances. (shrink)

Cet article analyse l'impact de la colonisation sur le statut des femmes en l'abordant sous l'angle des droits politiques tels quils furent définis dans le cadre des institutions coloniales : droit de vote, problématique du suffrage, participation aux assemblées… Quels furent les facteurs qui déterminèrent l'accès plus ou moins tardif des femmes à la sphère politique? De quelle marge de manœuvre disposèrent les colonisées face à des politiques qui restèrent longtemps marquées par des mentalités paternalistes? La comparaison des approches française (...) et britannique met en évidence les ambivalences des colonisateurs qui considérèrent les femmes tour à tour comme d'éternelles mineures, des alliées potentielles, à l'instar des femmes chefs de Sierra Leone, ou comme une nouvelle « ressource » politique au moment des indépendances. (shrink)

69 Thompson-Schill, S.L. _et al. _(1997) Role of left inferior prefrontal cortex 59 Buckner, R.L. _et al. _(1996) Functional anatomic studies of memory in retrieval of semantic knowledge: a re-evaluation _Proc. Natl. Acad._ retrieval for auditory words and pictures _J. Neurosci. _16, 6219–6235 _Sci. U. S. A. _94, 14792–14797 60 Buckner, R.L. _et al. _(1995) Functional anatomical studies of explicit and 70 Baddeley, A. (1992) Working memory: the interface between memory implicit memory retrieval tasks _J. Neurosci. _15, 12–29 and cognition (...) _J. Cogn. Neurosci. _4, 281–288 61 Bäckman, L. _et al. _(1997) Brain activation in young and older adults 71 Petrides, M. (1994) Frontal lobes and behavior _Curr. Opin. Neurobiol._ during implicit and explicit retrieval _J. Cogn. Neurosci. _9, 378–391. (shrink)

Sous l’impulsion de l’Institut Émilie du Chatelet, Carnal Knowledge and Imperial Power : Race and the Intimate in Colonial Rule (Berkeley, University of California Press, 2002) vient d’être traduit en français et publié par La Découverte, premier ouvrage de cette auteure prolifique et novatrice à être ainsi offert aux lecteurs francophones. Comment recevoir cette belle traduction une décennie après son édition originale, alors même qu’Ann Stoler continue d‘avancer d’un bon pas, creusant le mê...

Professeure de sciences politiques à l'Université du Québec à Montréal, spécialiste de l'ancien Soudan français et auteure de plusieurs articles consacrés aux femmes, Chantal Rondeau se livre à une étude en profondeur dans le temps et dans l'espace des paysannes du Mali. Sur trois générations et dans trois milieux différents (dogon, senufo et minyanka) elle met en évidence ce qu'elle appelle les « espaces de liberté » des femmes en milieu rural. Dans cette perspective, elle a opté po...

Me rendant à l’université de Bâle, je fus étonnée de voir notés sur les marches du grand escalier du bâtiment administratif, le Kollegienhaus, les noms, en ordre chronologique, des premières étudiantes admises, tardivement, à partir de 1890. Ce lieu de mémoire particulier marque les esprits. Il renvoie au premier pan des recherches reflétées dans ce livre : documenter l’apparition et l’accroissement des étudiantes puis des enseignantes dans les institutions d’enseignement supérieur. Fruit d’u...