In the last decades, Systems Biology (including cancer research) has been driven by technology, statistical modelling and bioinformatics. In this paper we try to bring biological and philosophical thinking back. We thus aim at making diferent traditions of thought compatible: (a) causality in epidemiology and in philosophical theorizing—notably, the “sufcient-component-cause framework” and the “mark transmission” approach; (b) new acquisitions about disease pathogenesis, e.g. the “branched model” in cancer, and the role of biomarkers in this process; (c) the burgeoning of omics (...) research, with a large number of “signals” and of associations that need to be interpreted. In the paper we summarize frst the current views on carcinogenesis, and then explore the relevance of current philosophical interpretations of “cancer causes”. We try to ofer a unifying framework to incorporate biomarkers and omic data into causal models, referring to a position called “evidential pluralism”. According to this view, causal reasoning is based on both “evidence of diference-making” (e.g. associations) and on “evidence of underlying biological mechanisms”. We conceptualize the way scientists detect and trace signals in terms of information transmission, which is a generalization of the mark transmission theory developed by philosopher Wesley Salmon. Our approach is capable of helping us conceptualize how heterogeneous factors such as micro and macro-biological and psycho-social—are causally linked. This is important not only to understand cancer etiology, but also to design public health policies that target the right causal factors at the macro-level. (shrink)

According to mental model theory, illusory inferences are a class of deductions in which individuals systematically go wrong. Mental model theory explains them invoking the principle of truth, which is a tendency not to represent models that falsify the premises. In this paper we focus on the illusory problems based on conditional sentences. In three experiments, we show that: (a) rather than not representing models that falsify the conditionals, participants have a different understanding of what falsifies a conditional (Experiment I); (...) (b) specifically, participants think that a conditional with an impossible antecedent or consequent is false (Experiment 2); (c) if the domain of the conditionals in the illusory problems are expanded to show that their antecedents and consequents are possible, the participants find it easy to reach the correct conclusions (Experiment 3). According to our results, the illusory inferences based on conditional premises, differently from those based on disjunctive premises, are caused by a difference between the understanding of natural language factual conditionals and the truth table of the factual implication; the principle of truth is not necessary to explain them. (shrink)

Manipulationism holds that information about the results of interventions is of utmost importance for scientific practices such as causal assessment or explanation. Specifically, manipulation provides information about the stability, or invariance, of the relationship between X and Y: were we to wiggle the cause X, the effect Y would accordingly wiggle and, additionally, the relation between the two will not be disrupted. This sort of relationship between variables are called 'invariant empirical generalisations'. The paper focuses on questions about causal assessment (...) and analyses the status of manipulation. It is argued that manipulationism is trapped in a dilemma. If manipulationism is read as providing a conceptual analysis of causation, then it fails to provide a story about the methods for causal assessment. If, instead, manipulationism is read as providing a method for causal assessment, then it is at an impasse concerning causal assessment in areas where manipulations are not performed. Empirical generalisations are then reassessed, in such a way that manipulation is not taken as methodologically fundamental. The paper concludes that manipulation is the appropriate tool for some scientific contexts, but not for all. (shrink)

Recent crises in Europe and beyond have renewed a longstanding debate on the status and treatment of refugees. Hannah Arendt famously questioned the limits of universalistic human rights discourse based on the widespread phenomena of statelessness and displacement that emerged during and after World War II. In this paper, we analyze recent patterns of inclusion and exclusion of refugees in Italy through the lens of Arendtian narrative and theorizing. We consider three cases of interaction between families, schools, and other public (...) institutions in light of the shifting normative framework before and during the war in Ukraine. Two major insights emerge from this analysis. From a pedagogical point of view, the most promising educational practices with refugees are those centered on enabling their agency and corresponding experiences of "natality". From an ethical-political perspective, these practices highlight a latent tension between the universalistic scope of human rights enshrined in the human rights declarations and their structural dependence on the particular norms and procedures enacted by nation states. The understanding and teaching of human rights within our political communities is inseparable from the practices that engage with refugees. In this sense, our practices of inclusion and exclusion affect the understanding of national borders as a barrier or threshold with other political communities, but also the interpretation of our own ethical-political principles. (shrink)

A proposal for the biological grounding of intrinsic teleology and sense-making through the theory of autopoiesis is critically evaluated. Autopoiesis provides a systemic language for speaking about intrinsic teleology but its original formulation needs to be elaborated further in order to explain sense-making. This is done by introducing adaptivity, a many-layered property that allows organisms to regulate themselves with respect to their conditions of viability. Adaptivity leads to more articulated concepts of behaviour, agency, sense-construction, health, and temporality than those given (...) so far by autopoiesis and enaction. These and other implications for understanding the organismic generation of values are explored. (shrink)

A proposal for the biological grounding of intrinsic teleology and sense-making through the theory of autopoiesis is critically evaluated. Autopoiesis provides a systemic lan- guage for speaking about intrinsic teleology but its original formulation needs to be elaborated further in order to explain sense-making. This is done by introducing adaptivity, a many-layered property that allows organisms to regulate themselves with respect to their conditions of via- bility. Adaptivity leads to more articulated concepts of behaviour, agency, sense-construction, health, and temporality than (...) those given so far by autopoiesis and enaction. These and other implications for understanding the organismic generation of values are explored. (shrink)

In a recent article, I have explored the historical, mathematical, and philosophical issues related to the new theory of numerosities. The theory of numerosities provides a context in which to assign numerosities to infinite sets of natural numbers in such a way as to preserve the part-whole principle, namely if a set A is properly included in B then the numerosity of A is strictly less than the numerosity of B. Numerosities assignments differ from the standard assignment of size provided (...) by Cantor’s cardinality assignments. In this talk, I generalize some specific worries emerging from the theory of numerosities to a line of thought resulting in what I call a ‘good company’ objection to Hume’s Principle (HP). The talk has four main parts. The first takes a historical look at 19th-century attributions of equality of numbers in terms of one-one correlations and argues that there was no agreement as to how to extend such determinations to infinite sets of objects. This leads to the second part where I show that there are countably infinite many abstraction principles that are ‘good’, in the sense that they share the same virtues of HP and from which we can derive the axioms of second order arithmetic. The third part connects this material to a debate on Finite Hume Principle between Heck and MacBride and states the ‘good company’ objection. Finally, the last part gives a tentative taxonomy of possible neo-logicist responses to the ‘good company’ objection and makes a foray into the relevance of this material for the issue of cross-sortal identifications for abstractions. (shrink)

Sentido ontológico de la paz. -- Sé lo que eres. -- Univresidad, humanidades, humanismo. -- Luces de Heráclito el oscuro. -- Bergson : psicología, moral, religión. -- Tolstoi, un hombre humanizado. -- Porras : el hombre venicó al ministro.

From Brouwer To Hilbert: The Debate on the Foundations of Mathematics in the 1920s offers the first comprehensive introduction to the most exciting period in the foundation of mathematics in the twentieth century. The 1920s witnessed the seminal foundational work of Hilbert and Bernays in proof theory, Brouwer's refinement of intuitionistic mathematics, and Weyl's predicativist approach to the foundations of analysis. This impressive collection makes available the first English translations of twenty-five central articles by these important contributors and many others. (...) The articles have been translated for the first time from Dutch, French, and German, and the volume is divided into four sections devoted to Brouwer, Weyl, Bernays and Hilbert, and the emergence of intuitionistic logic. Each section opens with an introduction which provides the necessary historical and technical context for understanding the articles. Although most contemporary work in this field takes its start from the groundbreaking contributions of these major figures, a good, scholarly introduction to the area was not available until now. Unique and accessible, From Brouwer To Hilbert will serve as an ideal text for undergraduate and graduate courses in the philosophy of mathematics, and will also be an invaluable resource for philosophers, mathematicians, and interested non-specialists. (shrink)

In this article, I draw upon the ‘post-Kantian’ reading of Hegel to examine the consequences Hegel’s idea of God has on his metaphysics. In particular, I apply Hegel’s ‘recognition-theoretic’ approach to his theology. Within the context of this analysis, I focus especially on the incarnation and sacrifice of Christ. First, I argue that Hegel’s philosophy of religion employs a distinctive notion of sacrifice (kenotic sacrifice). Here, sacrifice is conceived as a giving up something of oneself to ‘make room’ for the (...) other. Second, I argue that the idea of kenotic sacrifice plays a fundamental role in Hegel’s account of Christ. Third, I conclude by sketching some of the consequences of Hegel’s idea of a God who renounces his own divinity for an idealistically conceived metaphysics. My main thesis is that the notion of incarnation is conceived by Hegel as the expression of a spirit that advances only insofar as it is willing to withdraw and make room for the other. A kenotic reading of the Hegelian notion of the incarnation is also useful in terms of a clarification of the dispute between ‘left Hegelians’ and ‘right Hegelians’ concerning the status of the idea of God in Hegel’s philosophy. (shrink)

Causal analysis in the social sciences takes advantage of a variety of methods and of a multi-fold source of information and evidence. This pluralistic methodology and source of information raises the question of whether we should accordingly have a pluralistic metaphysics and epistemology. This paper focuses on epistemology and argues that a pluralistic methodology and evidence don’t entail a pluralistic epistemology. It will be shown that causal models employ a single rationale of testing, based on the notion of variation. Further, (...) I shall argue that this monistic epistemology is also involved in alternative philosophical theories of causation. (shrink)

In his third essay on earthquakes, Kant refers to “Pater Bina’s” electric interpretation of seismic phenomena. Although not a distinguished scholar, and maybe for that reason frequently confused with a certain “Father Isidore Binet”, Bina was nevertheless a noteworthy author. A Cassinese benedictine, Andrea Bina was a philosopher interested in sciences just like Kant; he studied Newton, translated Wolff, invented a seismoscope and was appreciated by his contemporaries at home and beyond the Alps. Kant’s laconic quotation, followed by a value (...) judgement regarding only Bina’s “audacity”, raises some questions, including, in primis those about the meaning of his hasty judgment. A plausible well-grounded answer should be looked for in the bio-bibliographical outline of the neglected author and in the perusal of his writings. The analysis of Bina’s Ragionamento sopra le cagioni de’ terremoti (1751) contributes to our knowledge of the eighteenth-century cultural background and helps us understand the degree of knowledge of the seismic phenomena acquired by men who – amidst many difficulties and hindered by the limits of their science – could only rely on secondhand data often imbued with misconceptions. Comparing Bina’s work – although indirectly – with Kant’s Fortgesetzte Betrachtung der seit einiger Zeit wahrgenommenen Erderschütterungen (1756) may help bring to light some convergences, as well as differences, which might be of use in clarifying some peculiarities of the Prussian Naturforscher. (shrink)

How should probabilities be interpreted in causal models in the social and health sciences? In this paper we take a step towards answering this question by investigating the case of cancer in epidemiology and arguing that the objective Bayesian interpretation is most appropriate in this domain.

A novel theoretical framework for an embodied, non-representational approach to language that extends and deepens enactive theory, bridging the gap between sensorimotor skills and language. -/- Linguistic Bodies offers a fully embodied and fully social treatment of human language without positing mental representations. The authors present the first coherent, overarching theory that connects dynamical explanations of action and perception with language. Arguing from the assumption of a deep continuity between life and mind, they show that this continuity extends to language. (...) Expanding and deepening enactive theory, they offer a constitutive account of language and the co-emergent phenomena of personhood, reflexivity, social normativity, and ideality. Language, they argue, is not something we add to a range of existing cognitive capacities but a new way of being embodied. Each of us is a linguistic body in a community of other linguistic bodies. The book describes three distinct yet entangled kinds of human embodiment, organic, sensorimotor, and intersubjective; it traces the emergence of linguistic sensitivities and introduces the novel concept of linguistic bodies; and it explores the implications of living as linguistic bodies in perpetual becoming, applying the concept of linguistic bodies to questions of language acquisition, parenting, autism, grammar, symbol, narrative, and gesture, and to such ethical concerns as microaggression, institutional speech, and pedagogy. (shrink)

We argue that the health sciences make causal claims on the basis of evidence both of physical mechanisms, and of probabilistic dependencies. Consequently, an analysis of causality solely in terms of physical mechanisms or solely in terms of probabilistic relationships, does not do justice to the causal claims of these sciences. Yet there seems to be a single relation of cause in these sciences - pluralism about causality will not do either. Instead, we maintain, the health sciences require a theory (...) of causality that unifies its mechanistic and probabilistic aspects. We argue that the epistemic theory of causality provides the required unification. (shrink)

Large Language Models (LLMs) are generative AI systems capable of producing original texts based on inputs about topic and style provided in the form of prompts or questions. The introduction of the outputs of these systems into human discursive practices poses unprecedented moral and political questions. The article articulates an analysis of the moral status of these systems and their interactions with human interlocutors based on the Habermasian theory of communicative action. The analysis explores, among other things, Habermas's inquiries into (...) the analogy between human minds and computers, and into the status of atypical participants in the linguistic community such as genetically modified subjects and animals. Major conclusions are the LLMs seem to qualify as authors that originally participate in discursive practices but do display only a structurally derivative form of communicative competence and fail to meet the status of communicative agents. In this sense, while the contribution of AI writing systems in public discourse and deliberation can support the process of mutual understanding within the community of speakers, the human actors involved in the development, use, and diffusion of these systems share a collective responsibility for the disclosure of AI authorship and verification and adjudication of validity claims. (shrink)

Scientific and philosophical literature on causality has become highly specialised. It is hard to find suitable access points for students, young researchers, or professionals outside this domain. This book provides a guide to the complex literature, explains the scientific problems of causality and the philosophical tools needed to address them.

Questo libro suggerisce d'inserire il nome di Arthur Schopenhauer nella tradizione della filosofia come stile di vita. Sulla scia dei pioneristici lavori di Paul Rabbow, Michel Foucault e soprattutto Pierre Hadot, si argomenta come anche nei libri di Schopenhauer questa tradizione sia viva. In particolare, è negli "Aforismi sulla saggezza della vita", contenuti nei "Parerga e paralipomena", che è possibile trovare traccia di quelle pratiche che Hadot ha proposto di chiamare esercizi spirituali. Ciò che ne emerge è un "altro" Schopenhauer. (...) Non più, non tanto, non solo il grande campione del pessimismo, il negatore della volontà di vita, il filosofo del dolore e della noia. Ma un prezioso suggeritore su come sia possibile vivere una vita se non proprio più felice, certamente il meno infelice possibile. (shrink)

This paper investigates the link between informational consequence and credence. I first suggest a natural constraint, namely that informational consequence should preserve certainty: on any rational credence distribution, when the premises of an informational inferences have credence 1, the conclusion also has credence 1. Then I show that the certainty‐preserving constraint leads to triviality. In particular, the following three claims are incompatible: (i) informational consequence is extensionally distinct from classical consequence; (ii) informational inferences preserve certainty; (iii) credences obey (a subset (...) of) classical Bayesian constraints. The proof is straightforward, but the theoretical implications are substantial. Informational theorists need to either give up the idea that credence applies to epistemic discourse, or develop a nonclassical theory of credence and credal update. Moreover, the result also suggests that there is a connection between informational consequence and triviality results, including classical triviality results like Lewis's. (shrink)

The literature on indicative conditionals contains two appealing views. The first is the selectional view: on this view, conditionals operate by selecting a single possibility, which is used to evaluate the consequent. The second is the informational view: on this view, conditionals don’t express propositions, but rather impose constraints on information states of speakers. Both views are supported by strong arguments, but they are incompatible on their standard formulations. Hence it appears that we have to choose between mutually exclusive options. (...) But the options are not exclusive. This paper develops a theory of the semantics and assertability of conditionals that is both selectional and informational. The theory vindicates the signature inferences of both selectional and informational theories, including so-called Conditionals Excluded Middle and principles about the interplay between conditionals and ‘might’. It also predicts some interesting and puzzling facts about the assertion of conditionals. (shrink)

This article begins by examining the status of “difference” in representations of perspectivist cosmologies, which are themselves often represented as radically different to Euro-American cosmologi...

That words express a conceptual content is uncontroversial. This does not entail that their content should break down neatly into a grammatical part, relevant for language and to be analyzed in linguistic terms, and a conceptual part, relevant for cognition and to be analyzed in psychological terms. Various types of empirical evidence are reviewed, showing that the conceptual content of words cannot be isolated from their linguistic properties, because it is affected and shaped by them. The view of words as (...) labels or containers for a non-linguistic conceptual content stems from a naive disregard of the complex and structured nature of lexical knowledge. On the contrary, knowledge of language is shown not just to organize and categorize conceptual content in a way not reducible to non-linguistic cognition, but also to affect its scope, as the range of verbalized concepts is both limited by abstract templates and expanded by productive word formation. This suggests that lexical knowledge is a distinctively linguistic dimension of conceptualization, and that words do not so much label or package concepts, as provide an inner form for conceptual knowledge. (shrink)

Natural language conditionals seem to be subject to three logical requirements: they invalidate Antecedent Strengthening, they validate so-called Simplification of Disjunctive Antecedents, and they allow for the replacement of logically equivalent clauses in antecedent position. Unfortunately, these requirements are jointly inconsistent. Conservative solutions to the puzzle drop Simplification, treating it as a pragmatic inference. I show that pragmatic accounts of Simplification fail, and develop a truthmaker semantics for conditionals that captures all the relevant data. Differently from existing truthmaker semantics, my (...) semantics extends, rather than replaces, standard possible worlds semantics. The main innovation is the notion of a truthmaker in play: this notion is cognitive, rather than metaphysical, and can be defined in a purely syntactic way. (shrink)

Christ as symbol in Kant¿s religion -- Hegel's conception of God -- The reality of religion in Hegel's idealist metaphysics -- Hegel's version of the ontological argument for the existence of God -- The trinity and the I -- The death of God and recognition of the self -- Beyond subjectivism -- The relevance of Hegel's philosophy of religion today.

Heinrich Behmann (1891-1970) obtained his Habilitation under David Hilbert in Göttingen in 1921 with a thesis on the decision problem. In his thesis, he solved - independently of Löwenheim and Skolem's earlier work - the decision problem for monadic second-order logic in a framework that combined elements of the algebra of logic and the newer axiomatic approach to logic then being developed in Göttingen. In a talk given in 1921, he outlined this solution, but also presented important programmatic remarks on (...) the significance of the decision problem and of decision procedures more generally. The text of this talk as well as a partial English translation are included. (shrink)

This paper investigates what happens when we merge two different lines of theorizing about counterfactuals. One is the comparative closeness view, which was developed by Stalnaker and Lewis in the framework of possible worlds semantics. The second is the interventionist view, which is part of the causal models framework developed in statistics and computer science. Common lore and existing literature have it that the two views can be easily fit together, aside from a few details. I argue that, on the (...) contrary, transplanting causal-models-inspired ideas in a possible worlds framework yields a new semantics. The difference is grounded in different algorithms for handling inconsistent information, hence it touches on issues that are at the very heart of a semantics for contrary-to-fact conditionals. Roughly, Stalnaker/Lewis semantics requires us to evaluate the consequent of a counterfactual at all closest antecedent-verifying possibilities. Causal-models-based semantics also does this, but in addition uses the information contained in the antecedent, together with background causal information, to shift what worlds count as closest. This makes systematically different predictions and generates a new logic. The upshot is that we have a new semantics to study, and a substantial theoretical choice to make. (shrink)